This confocal image shows a cortical region of a Somatostatin-Cre+/; Floxopatch+/ mouse. Somatostatin antibody (red) colocalizes with Floxopatch GFP expression (green), indicating a tight Cre-loxP system in this conditional mouse line. The recordings show optically induced action potentials from in vitro cultured dorsal root ganglia with voltage sensor QuasAr2 (red trace) and whole-cell patch clamp (white trace). The close correlation of the two traces indicates the high fidelity of the voltagesensitive fluorescence protein and the voltage activities. Cover image produced by Shan Lou. For more information, see the article by Lou et al. (pages 1105911073).

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Journal of Neuroscience