Nazneen Rahman at the day job: head of genetics, Institute of Cancer Research and the Royal Marsden Hospital. Photograph: Wellcome
Ive had an exciting and unusual few weeks. My group published a scientific paper revealing a new genetic cause of a childhood kidney cancer called Wilms tumour. This discovery has been of immediate benefit to families, providing an explanation for why their child got cancer, and information about cancer risks for other family members. During the same period, I also released my second album of original songs, called Answers No Questions. On one day, I found myself singing live on Radio London in the morning and talking genetics to the World Service in the evening.
Over the past few weeks, I have found it increasingly difficult to know quite how to answer the ubiquitous question what do you do?
For most of my adult life, I have replied: Im a scientist and a doctor. It is an accurate description. I am professor of human genetics at the Institute of Cancer Research, London, and head of cancer genetics at the Royal Marsden Hospital. For 20 years, my work has focused on identifying gene mutations that predispose us to getting cancer and then using that information to help patients and their families.
But I am also a singer-songwriter. This is a smaller activity than my science, but far more than hobby. I release music that people pay good money to experience.
As my music has become better known, more and more people have asked me about my unusual career combination. Dubiously, admiringly, wistfully, jealously, but most often simply because they are intrigued by the motivations and the practicalities.
This has forced me to consider how, if at all, these parts of my life are related. At first, I was adamant they were distinct facets of my character. I railed against modern societys pervasive need to simplify and pigeon-hole the human spirit. Most people have multiple passions and drivers. I am fascinated by these subterranean pursuits. One of the joys of sharing my previously secret musical existence (its not been all joy but thats another column) is that many scientists now share their secret passions with me pot throwing, flugel playing, novelty cakemaking, fire eating scientists are as wondrously idiosyncratic in their appetites as the rest of society.
I also rail against the cliche that people are drawn to science and music because they both have a mathematical basis. It may be true for some, but it has no relevance to my passion for music. I was singing complex harmonies to pop songs long before I learned the theory of music. I am an intuitive, emotional, spontaneous songwriter with little idea of the key, notes or time I am composing in until I have to write it down. There is little science in my music, but I have come to believe there may be music in my science. There is a kinship in how I do science and how I make music that flouts the division of science and the arts that our education system promotes.
My branch of science is genetics. Genetics is underpinned by a simple four-letter DNA code (designated by A, C, G, T). This code dictates how our bodies work. And how they can fail. This beautiful code is framed, shaped, constrained and enhanced by a multitudinous orchestra of associates that determine when, how, where, how long and how strong different parts of the code are played in each of our 30tn cells. DNA is also extraordinary in being able to copy itself with unbelievable accuracy while retaining the ability to mutate and evolve. The sophisticated controls and balances are breathtaking in their elegance. Our recent childhood cancer gene discovery revealed some insights into these control mechanisms and how cancer can occur if they go wrong. Studying genetics provides an endless variety of patterns to unravel, problems to solve, questions to answer. Gratifyingly, it also provides endless opportunities to bring benefits to humanity. In a hundred lifetimes I would not run out of genetic questions that excite me.
Music is underpinned by a simple 12-letter note code (designated by C, C#, D, D#, E, F, F#, G, G#, A, A#, B). These notes can be layered in almost infinite ways to produce music. In a hundred lifetimes I would not run out of music to write. My challenge has never been about finding the time to write songs, it has always been about finding the time to not lose songs. Snippets of music and lyrics are my constant companions. Most disappear into the clouds like lost balloons. But every now and again, I reach up, grab a string and tie one down, just before it is lost for ever.
Science and music make me feel like Im swimming in infinity pools of possibility, but within structures that keep me from drowning. The potential and expectation to keep delivering new things can be daunting to scientists and artists. The DNA code in genetics and the note code in music are my lifelines. They let me be audacious and unfettered. They give me confidence to dive in, even when I cant see the shore on the other side.
And the practicalities of delivering science and music are quite similar for me. Science is typically funded as three- to five-year projects. For example, I am currently leading a 4m collaborative programme, called the Transforming Genetic Medicine Initiative, which is building the knowledge base, tools and processes needed to deliver genetic medicine. To get science funding, you need to present, in great detail, a persuasive, innovative concept that seems worthwhile and feasible. But once you receive the funding there is considerable creative licence to alter the project, within the overall concept, because science is fast moving. You cannot predict everything you will do at the cutting-edge of knowledge, five years in advance.
My albums have also had three-year lifespans, though I didnt plan it that way. I dont plan them at all. My songs tend to be stories about the complexities of everyday life, inspired by words, subjects or images that briefly, randomly, ensnare me. I dont know what the songs will be about before I write them. There is no overall concept for the albums, at least not consciously. And yet I see now that each album had a central theme that wasnt apparent to me when I was writing them. Cant Clip My Wings, which I released in 2014, includes songs about how we adapt to loss. Lost loves, lost lives, lost dreams. My new album, Answers No Questions, includes songs about choice the complexities, burdens, excitement, pain and joys of making choices.
As I am writing this, I wonder if I am forcing these connections, if they are a post-hoc construct that allows me to give a more pleasing answer to why I am both scientist and songwriter. But I have truly come to believe that, in me, science and music are different manifestations of the same need. A central deep desire to create new things elegant, beautiful, new things. It doesnt much matter if its a scientific discovery, a clinic protocol that makes things easier for patients or a song that tells a human story from a fresh perspective. When it works it feels amazing. Even when it doesnt work, the journey is always paved with nuggets of enlightenment that feed into future creations.
So what do I do?
I think, at my core, I am a creative, though it would be perplexing to many if I started to describe myself this way. Science and music are the mediums in which I happen to create, undoubtedly an unusual combination. But maybe only because we are relentlessly conditioned, from an early age, to believe we must choose whether we are in the science or the arts camp. People from the arts camp routinely tell me they were hopeless at science, sometimes apologetically, sometimes as a badge of honour, a mark of their creativity. Likewise, scientists worry that any proficiency in creativity might be interpreted as a deficiency in objectivity, the bedrock of science. It seems our society has lapsed into considering activity in the sciences and the arts a zero-sum game. It is not.
What would happen if we stopped constraining ourselves and our children in this way? If we embraced and fostered fluid boundaries between the sciences and the arts? If many more people were able to cross freely in and out of both worlds, successfully and unapologetically?
I believe science, art, individuals and society would reap countless benefits.
Answers No Questions is out now; nazneenrahman.com
See more here:
Nazneen Rahman: 'Science and music are mediums in which I create' - The Guardian
- Toward advances in retinoblastoma genetics in Kenya - Nature.com - November 12th, 2024 [November 12th, 2024]
- CRISPR/Cas9 screens identify key host factors that enhance rotavirus reverse genetics efficacy and vaccine production - Nature.com - November 12th, 2024 [November 12th, 2024]
- Genetics Play Key Role in Animal Health and Welfare, Aggression and Handling - Farms.com - November 12th, 2024 [November 12th, 2024]
- Episode 174: Rudy Tanzi talks about genetics, aging and the hallmarks of Alzheimers - IHMC - October 26th, 2024 [October 26th, 2024]
- Ocuphire and Opus Genetics merge to develop IRD gene therapy - Pharmaceutical Technology - October 26th, 2024 [October 26th, 2024]
- The RD Fund Announces Ocuphire Pharma's Acquisition of Opus Genetics - PR Newswire - October 26th, 2024 [October 26th, 2024]
- The RD Fund Announces Ocuphire Pharma's Acquisition of Opus Genetics - WV News - October 26th, 2024 [October 26th, 2024]
- Faculty of Science | Protecting Canadas number one crop through genetics - UM Today - October 26th, 2024 [October 26th, 2024]
- Ocuphire and Opus Genetics merge to develop IRD gene therapy - Yahoo Finance - October 26th, 2024 [October 26th, 2024]
- Opinion | Fascinated by genetics? Where are the peas Trump made to fornicate? - The Washington Post - October 13th, 2024 [October 13th, 2024]
- Dietary restriction can extend lifespan but genetics matters more - Nature.com - October 13th, 2024 [October 13th, 2024]
- 'They have much stronger players' - Bangladesh assistant coach bizarrely blames 'genetics' for lack of six hitters in the team - Sporting News - October 13th, 2024 [October 13th, 2024]
- Medical Moment: Genetics and breast cancer with USA Health Genetic Counselor Cassie Gurganus - AOL - October 13th, 2024 [October 13th, 2024]
- Myriad Genetics Announces Five Research Collaborations to Study the Use of MRD Testing in Breast Cancer - Yahoo Finance - October 13th, 2024 [October 13th, 2024]
- An ideologically-based and misleading critique of how modern genetics is taught - Why Evolution Is True - October 13th, 2024 [October 13th, 2024]
- 2024 Mercedes-AMG C63 Review: Bold But Beholden to Its Genetics - Newsweek - October 2nd, 2024 [October 2nd, 2024]
- Myriad Genetics Announces Third Patent Granted for Molecular Residual Disease (MRD) with Early Priority Date - GlobeNewswire - October 2nd, 2024 [October 2nd, 2024]
- Digbi Health Launches an SEC-regulated Offering, Giving Millions the Opportunity to Invest in Groundbreaking Genetics and Gut Microbiome-based Care... - October 2nd, 2024 [October 2nd, 2024]
- The role of genetics in depression | Second Opinion - KCRW - September 23rd, 2024 [September 23rd, 2024]
- Tilapia genetics company Spring Genetics teams up with UK data firm to improve fish welfare - SeafoodSource - September 23rd, 2024 [September 23rd, 2024]
- Picky eating in kids is mostly due to genetics, study says - Motherly Inc. - September 23rd, 2024 [September 23rd, 2024]
- Research Shows That Fussy Eating In Children Is Mainly Influenced By Genetics - RTTNews - September 23rd, 2024 [September 23rd, 2024]
- Genetics colloquium: Chris Hittinger on the genomic making of metabolic niche breadth Sep. 11 - University of WisconsinMadison - September 15th, 2024 [September 15th, 2024]
- NIH Recognizes Yales Expertise in the Genetics of Rare Diseases - Yale School of Medicine - September 15th, 2024 [September 15th, 2024]
- SOPHiA GENETICS and AstraZeneca Collaborate to Further Expand Global Access to Liquid Biopsy Testing - PR Newswire - September 15th, 2024 [September 15th, 2024]
- Medicines race dilemma: What science says about genetics and health [PODCAST] - Kevin MD - September 15th, 2024 [September 15th, 2024]
- Researchers want to unlock genetics of the worlds tiniest animals - Popular Science - September 15th, 2024 [September 15th, 2024]
- Sophia Genetics and AstraZeneca collaborate to expand liquid biopsy test rollout - Medical Device Network - September 15th, 2024 [September 15th, 2024]
- From farm to future: Technology in genetics - National Hog Farmer - September 2nd, 2024 [September 2nd, 2024]
- Editorial: Plant biotechnology and genetics for sustainable agriculture and global food security - Frontiers - September 2nd, 2024 [September 2nd, 2024]
- NSF Grant Brings Genetics Opportunities to Students in Alabama - Government Technology - September 2nd, 2024 [September 2nd, 2024]
- SBUs Ben Luft brings Lyme expertise to seminal paper on bacterial genetics and evolution - TBR News Media - September 2nd, 2024 [September 2nd, 2024]
- SOPHiA GENETICS to Present at the 22nd Annual Morgan Stanley Healthcare Conference and 9th Annual TD Cowen FutureHealth Conference - PR Newswire - September 2nd, 2024 [September 2nd, 2024]
- Singapores National Precision Medicine (NPM) Programme Engages Oxford Nanopore to Advance Understanding of the Genetics of Singapores Multi-Ethnic... - August 5th, 2024 [August 5th, 2024]
- Fulgent Genetics Second Quarter 2024 Earnings: Beats Expectations - Yahoo Finance - August 5th, 2024 [August 5th, 2024]
- Stopped clinical trials give evidence for the value of genetics - Nature.com - August 5th, 2024 [August 5th, 2024]
- What is DSD? Sex genetics and Olympic boxing controversy - Washington Examiner - August 5th, 2024 [August 5th, 2024]
- Fulgent Genetics Q2: Core Revenue Grows, but Profitability Is Still an Issue - The Motley Fool - August 5th, 2024 [August 5th, 2024]
- Viewpoint: Challenging yet another scientifically silly article claiming Black domination of sprinting and long distance running has nothing to do... - August 5th, 2024 [August 5th, 2024]
- Texas Company Trying To Resurrect Woolly Mammoths To Improve Genetics Of Bison - Cowboy State Daily - August 5th, 2024 [August 5th, 2024]
- Genetics confirms Berbers reached North Africa over 20,000 years ago; Arabs came in 7th Century CE - Down To Earth Magazine - August 5th, 2024 [August 5th, 2024]
- Unlocking plant genetics with telomere-to-telomere genome assemblies - Nature.com - July 26th, 2024 [July 26th, 2024]
- Carlo Ancelotti claims Jude Bellingham's 'genetics' are main reason behind Real Madrid & England superstar's meteoric rise to the top - Goal.com - July 26th, 2024 [July 26th, 2024]
- Genetics-based modeling estimates Idaho's wolf population was 1,150 in summer 2023 - Idaho Fish and Game - July 26th, 2024 [July 26th, 2024]
- Lung Cancer Research Foundation Joins Lung Cancer Advocacy Organizations and 23andMe to Launch Lung Cancer Genetics Study to Advance Research - PR... - July 26th, 2024 [July 26th, 2024]
- Fulgent Genetics (FLGT) Scheduled to Post Earnings on Friday - Defense World - July 26th, 2024 [July 26th, 2024]
- SOPHIA GENETICS Announces Expanded Relationship with Canada-Based OncoHelix - Financial Times - July 26th, 2024 [July 26th, 2024]
- LG Household & Health Care publishes research into the genetics of skin tone - GlobalCosmeticsNews - July 26th, 2024 [July 26th, 2024]
- Estonians gave their DNA to science now they're learning their genetic secrets - Nature.com - June 27th, 2024 [June 27th, 2024]
- Genetic clues to depression revealed in large study - PsyPost - June 27th, 2024 [June 27th, 2024]
- Move Over, Genghis Khan. Many Other Men Left Huge Genetic Legacies - Smithsonian Magazine - June 27th, 2024 [June 27th, 2024]
- 3X4 Genetics Selected as Partner for Preeminent Cancer Research and Treatment Nonprofit, The Metabolic Terrain ... - BioSpace - June 27th, 2024 [June 27th, 2024]
- NIFA Invests $6M in Animal Breeding, Genetics and Genomics | NIFA - National Institute of Food and Agriculture - June 27th, 2024 [June 27th, 2024]
- Arbel Harpak: Pursuing the Next Frontier in Genetics | Dell Medical School - Dell Medical School - June 27th, 2024 [June 27th, 2024]
- Coffee habits are partly linked to genetics, UC San Diego researchers say - NBC San Diego - June 27th, 2024 [June 27th, 2024]
- Advanced genetic tools help researchers ID new neurodevelopmental syndrome - Yale News - June 27th, 2024 [June 27th, 2024]
- Nutritious diet may protect against type 2 diabetes, regardless of genetics - News-Medical.Net - June 27th, 2024 [June 27th, 2024]
- Genome-wide association study identifies host genetic variants influencing oral microbiota diversity and metabolic ... - Nature.com - June 27th, 2024 [June 27th, 2024]
- Unlock the Secrets of Your DNA with Advanced Genetic Testing - North Forty News - June 27th, 2024 [June 27th, 2024]
- Modern and precise: Using gene editing to change the blueprint of an organism - Beef Magazine - June 27th, 2024 [June 27th, 2024]
- The 'gene deserts' unravelling the mysteries of disease - BBC.com - June 27th, 2024 [June 27th, 2024]
- UGA plant geneticists are tackling the climate crisis - Longview News-Journal - June 27th, 2024 [June 27th, 2024]
- Genetic Tests for Predicting Clopidogrel Response Gain Traction: AHA - TCTMD - June 27th, 2024 [June 27th, 2024]
- Bringing Gene Therapy to the Brain - The Scientist - June 27th, 2024 [June 27th, 2024]
- The importance of the paradise fish in evolutionary and behavioral genetics research - Phys.org - June 9th, 2024 [June 9th, 2024]
- What Is Fulgent Genetics, Inc.'s (NASDAQ:FLGT) Share Price Doing? - Yahoo Finance - June 9th, 2024 [June 9th, 2024]
- UW initiative aims to bring together social sciences and genetics - Wisbusiness.com - June 9th, 2024 [June 9th, 2024]
- Women have a higher genetic risk for PTSD, according to study by VCU and Swedish researchers - VCU News - June 9th, 2024 [June 9th, 2024]
- Genetics study points to potential treatments for restless leg syndrome - University of Cambridge news - June 9th, 2024 [June 9th, 2024]
- deCODE genetics: The rate, nature and transmission of mitochondrial DNA mutations in humans - PR Newswire - June 9th, 2024 [June 9th, 2024]
- Genetic association mapping leveraging Gaussian processes | Journal of Human Genetics - Nature.com - June 9th, 2024 [June 9th, 2024]
- Minimally destructive hDNA extraction method for retrospective genetics of pinned historical Lepidoptera specimens ... - Nature.com - June 9th, 2024 [June 9th, 2024]
- Restless legs syndrome tied to 140 'hotspots' in the genome - Livescience.com - June 9th, 2024 [June 9th, 2024]
- Paired tumor-germline testing can enhance patient carewith guidance from genetics specialists - The Cancer Letter - June 9th, 2024 [June 9th, 2024]
- Improved functional mapping of complex trait heritability with GSA-MiXeR implicates biologically specific gene sets - Nature.com - June 9th, 2024 [June 9th, 2024]
- Genetic Risk Score Revolutionizes TNBC Prediction in Black Women - Targeted Oncology - June 9th, 2024 [June 9th, 2024]
- Gene variants and breast cancer risk in Black women - National Institutes of Health (NIH) (.gov) - June 9th, 2024 [June 9th, 2024]
- GSA-MiXeR: A powerful tool to improve our understanding of heritable traits and diseases - News-Medical.Net - June 9th, 2024 [June 9th, 2024]
- Understanding the effect genetics have on Alzheimer's - Buffalo News - June 9th, 2024 [June 9th, 2024]
- 'Fossil viruses' embedded in the human genome linked to psychiatric disorders - Livescience.com - June 9th, 2024 [June 9th, 2024]