Grey's Anatomy has been on the air for 15 years, so it makes sense that a lot of big Hollywood names have popped up for guest slots over the last 16 seasons.

Established actors like Christina Ricci and Sarah Paulson have graced the halls of Seattle Grace hospital, as well as some young actors who went on to have big careers: Millie Bobby Brown and Abigail Breslin, to name a few.

Read more from the original source:
Grey's Anatomy cast: 19 famous guest stars and celebrity cameos from the last fifteen years - 9TheFIX