New research provides strong evidence that COVID-19 is aseasonal infection linked to low temperatures and humidity, much like seasonal influenza.

A new study led by the Barcelona Institute for Global Health (ISGlobal), an institution supported by la Caixa Foundation, provides robust evidence that COVID-19 is aseasonal infection linked to low temperatures and humidity, much like seasonal influenza. The results, published inNature Computational Science, also support the considerable contribution of airborne SARS-CoV-2 transmission and the need to shift to measures that promote air hygiene.

A key question regarding SARS-CoV-2 is whether it is behaving, or will behave, as a seasonal virus like influenza, or whether it will be equally transmitted during any time of the year. Afirst theoretical modeling study suggested that climate was not a driverin COVID-19 transmission, given the high number of susceptible individuals with no immunity to the virus. However, some observations suggested that the initial propagation of COVID-19 in China occurred in a latitude between 30 and 50oN, with low humidity levels and low temperatures (between 5oand 11oC).

The question of whether COVID-19 is a genuine seasonal disease becomes increasingly central, with implications for determining effective intervention measures, explainsXavier Rod, director of theClimate and Health program at ISGlobal and coordinator of the study. To answer this question, Rod and his team first analyzed the association of temperature and humidity in the initial phase of SARS-CoV-2 spread in 162 countries across five continents, before changes in human behavior and public health policies were put into place. The results show a negative relationship between the transmission rate (R0) and both temperature and humidity at the global scale: higher transmission rates were associated with lower temperatures and humidity.

The team then analyzed how this association between climate and disease evolved over time, and whether it was consistent at different geographical scales. For this, they used a statistical method that was specifically developed to identify similar patterns of variation (i.e. a pattern-recognition tool) at different windows of time. Again, they found a strong negative association for short time windows between disease (number of cases) and climate (temperature and humidity), with consistent patterns during the first, second, and third waves of the pandemic at different spatial scales: worldwide, countries, down to individual regions within highly affected countries (Lombardy, Thringen, and Catalonia) and even to the city level (Barcelona).

The first epidemic waves waned as temperature and humidity rose, and the second wave rose as temperatures and humidity fell. However,this pattern was broken during summertime in all continents. This could be explained by several factors, including mass gatherings of young people, tourism, and air conditioning, among others, explainsAlejandro Fontal, researcher at ISGlobal and first author of the study.

When adapting the model to analyze transient correlations at all scales in countries in the Southern Hemisphere, where the virus arrived later, the same negative correlation was observed. The climate effects were most evident at temperatures between 12oand 18oC and humidity levels between 4 and 12 g/m3, although the authors warn that these ranges are still indicative, given the short records available.

Finally, using an epidemiological model, the research team showed thatincorporating temperature into the transmission rate works better for predicting the rise and fall of the different waves, particularly the first and third ones in Europe. Altogether, our findings support the view of COVID-19 as a true seasonal low-temperature infection, similar to influenza and to the more benign circulating coronaviruses, says Rod.

This seasonality could contribute importantly to the transmission of SARS-CoV-2, since low humidity conditions have been shown to reduce the size of aerosols, and thereby increase airborne transmission of seasonal viruses such as influenza. This link warrants anemphasis on air hygienethrough improved indoor ventilationas aerosols are capable to persist suspended for longer times, says Rod, and highlights theneed to include meteorological parameters in the evaluation and planning of control measures.

Reference: Climatic signatures in the different COVID-19 pandemic waves across both hemispheres by Fontal A, Bouma MJ, San Jos A, Lopez L, Pascual M, Rod X, 21 October 2021, Nature Computational Science.DOI: 10.1038/s43588-021-00136-6

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Strong Evidence That COVID-19 Is a Seasonal Infection And We Need Air Hygiene - SciTechDaily