Higher coffee consumption was tied to slower cognitive decline and less cerebral amyloid-beta accumulation over 126 months, an Australian study showed. (Frontiers in Aging Neuroscience)

Physical activity may promote synaptic and cognitive resilience by reducing pro-inflammatory microglial states. (Journal of Neuroscience)

Housework was linked to higher attention and memory scores and better sensorimotor function in older adults, independent of other types of regular physical activity. (BMJ Open)

White matter hyperintensities may capture long-term pathologies from repetitive head impacts, a study of deceased football players and other men suggested. (Neurology)

Also in Neurology: Danish epilepsy patients under age 50 had a nearly fourfold increased risk of all-cause mortality than their counterparts without epilepsy.

Japan's Kazuo Hasegawa, MD, PhD, a dementia researcher who later was diagnosed with the disease, died in Tokyo at age 92. (Wall Street Journal)

The Glasgow Coma Scale (GCS) verbal component did not significantly contribute to total GCS score in mortality prediction of non-intubated encephalopathic patients. (Neurology)

To help people with long COVID, researchers need to decide which of 200 reported symptoms to study, a Wired writer observed.

Compared with placebo, teriflunomide (Aubagio) showed no significant difference in time to first confirmed clinical relapse in children with relapsing multiple sclerosis, the TERIKIDS study showed. (Lancet Neurology)

Gene-editing pioneer David Liu, PhD, of the MIT-Harvard Broad Institute, is investigating a possible therapy that installs a protective gene to prevent Alzheimer's disease. (Insider)

Judy George covers neurology and neuroscience news for MedPage Today, writing about brain aging, Alzheimers, dementia, MS, rare diseases, epilepsy, autism, headache, stroke, Parkinsons, ALS, concussion, CTE, sleep, pain, and more. Follow

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Coffee and Cognitive Decline; Head Impact Injuries; Alzheimer's Gene Therapy? - MedPage Today