Grey's Anatomy stars Ellen Pompeo and Patrick Dempsey have said how much they'd like to work together again.

The pair played iconic couple Dr Meredith Grey and Dr Derek Shepherd on the long-running show from its start in 2005, until Dempsey left the series in 2011.

They did recently reunite in the show's famous beach sequence, as Meredith battled COVID-19.

Speaking about whether an opportunity would come up again, Dempsey said he had "some ideas" of how it would work.

"I'll tell her first and then we'll see if we can realise it," the Disenchanted star told Extra. "It's always been a really special relationship Ellen and I have had together in front of the screen and behind it as well.

"I remember the first time I met her, she had a Boston accent, and I'm from Maine originally, so it was very endearing and had that connection right away."

Speaking of the show's success, he added: "People want to believe in love and all of that.

"People around the world, too, were wishing we were actually together. But she's got Christopher [Ivery] and I have Jillian [Fink], and they're incredible people, so fortunately they have that with us."

Pompeo, who is taking a reduced role in the upcoming series, added: "I think the fans out love it, and we'd be 100% open to it. I would anyway. If the material was right, I think it would be so fun for the fans."

"We've done some of our greatest work together," she said. "I think both of us are very proud of the work we did, we had a great time doing it and we created something really iconic."

Dempsey, sporting a new white hairstyle, also crashed Pompeo's red carpet interview at the D23 expo, taking over the microphone and asking her questions.

Asking her if she'd do 30 seasons of Grey's, she responded: "I'm not going to do 30 seasons, I'm going to do 8 episodes.

"There's someone missing from the show, I can't think of who it is. Someone who was a big part of the show and it hasn't been the same without that person," she added.

"Justin Chambers," Dempsey suggested, with the pair agreeing, before joking about Eric Dane coming back.

Grey's Anatomy returns for season 19 on October 6, airing on ABC in the US. In the UK, seasons 1-17 are streaming on Disney+, while season 18 is available via Sky Witness and NOW.

Grey's Anatomy Season 17 DVD [2021]

Watch Grey's Anatomy with Disney+

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How to Save a Life: The Inside Story of Grey's Anatomy by Lynette Rice

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Grey's Anatomy's Ellen Pompeo and Patrick Dempsey tease working together again - Digital Spy