Four Abstracts on Eblasakimab and Farudodstat to be Presented at … – Dermatology Times

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The 1st International Societies for Investigative Dermatology (ISID) Meeting takes place next week, May 10-13, 2023, in Tokyo, Japan. ASLAN Pharmaceuticals will present 2 late-breaker presentations and 2 published abstracts on eblasakimab for atopic dermatitis and farudodstat for alopecia areata.

Late-breaker presentation:

Late-breaker poster presentation:

Published abstracts:

1. Eblasakimab monotherapy improves moderate-to-severe atopic dermatitis symptoms across anatomical regions in a phase 1 study (abstract ID: 657)

ASLANs first published abstract at ISID explores eblasakimab as monotherapy for moderate-to-severe atopic dermatitis across varying regions of the body. According to the background of the study, the clinical presentation of atopic dermatitis varies by anatomical location due to differences in skin area sensitivity and can therefore limit a patients long-term treatment options. New research shows that interleukin-4 (IL-4) and IL-13 signal through a type 2 receptor complex composed of IL-4R1 and IL-13R1 to mediate the pathogenesis of atopic dermatitis.

Eblasakimab obstructs the signaling cascade by binding to the IL-13R1 subunit. The phase 1b subgroup analysis analyzed the effects of eblasakimab on Eczema Area and Severity Index (EASI) across varying anatomical regions compared to placebo. Investigators found that patients treated with 400mg or 600mg of subcutaneous eblasakimab once a week showed notable improvement in percent change from baseline in EASI scores across 4 anatomic regions of the head/neck, trunk, upper extremities, and lower extremities, compared to placebo.

2. Neuromodulation beyond itch is blocked by targeting IL-13R1 with eblasakimab (abstract ID: 1594)

The second published ASLAN abstract at ISID evaluated whether IL-4 and IL-13 exert redundant or distinct functions in human sensory neurons, and whethereblasakimabcanattenuate cytokine-enhanced neuronal responses to itch andreduce spontaneous neuronal activity. According to the abstract, Human dorsal root ganglia neurons were treated with IL-4, IL-13, or their combination with or withouteblasakimaband subsequently either challenged with pruritogens (BAM8-22 and PAMP-20) or tested for spontaneous neuronal activity. Neuronal responses to pruritogens and spontaneous neuronal activity were measured via live-cell calcium imaging.

IL-4, IL-13, and their combination treatments enhanced neuronal responses to the non-histaminergic pruritogen (BAM-822) when applied to human dorsal root ganglion, and IL-13 treatment increased neuronal responses to the histaminergic pruritogen (PAMP-20) through amplifications of the activity of MRGPRX2. Investigators noted that this suggests a novel neuroimmune pathway besides its mast cell specific function

Updates

Eblasakimab, a potential first-in-class antibody targeting the IL-13 receptor in moderate-to-severe atopic dermatitis is being studied in a global phase 2b trial of patients with moderate-to-severe atopic dermatitis with topline data expected in early July 2023. Farudodstat, a potent oral inhibitor of the enzyme DHODH and potential first-in-class treatment for alopecia areata is also under development. ASLAN plans to initiate a proof-of-concept trial in 2Q 2023.

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