Summary: The risk of developing long COVID symptoms may be significantly increased in adults with sleep apnea, according to a new study.
This increased risk persisted even when controlling for other factors known to contribute to long COVID, such as obesity, hypertension, diabetes, and hospitalization at the time of initial COVID infection. Notably, the link between sleep apnea and long COVID was not observed in children when other risk factors were accounted for.
This research underlines the importance of early COVID treatment and symptom vigilance in sleep apnea patients.
Key Facts:
1 Adults with sleep apnea have a significantly increased risk of developing long COVID symptoms, according to a study by the National Institutes of Healths RECOVER Initiative and NYU Langone Health.
2 The increased risk for long COVID in adults with sleep apnea persisted even when accounting for factors such as obesity, hypertension, diabetes, and initial COVID hospitalization.
3 In contrast to the patterns seen in adults, the contribution of sleep apnea to the risk of long COVID was not significant in children when controlled for other risk factors.
Source: NYU Langone
Sleep apnea may significantly increase the risk for long COVID in adults, according to a study led by theNational Institutes of Healths RECOVER Initiativeand supported by NYU Langone Health as home to the efforts Clinical Science Core (CSC).
As ofApril 2023,more than 100 million Americans had been infected with the virus that causes COVID-19. As of April the U.S.Governments Household Pulse survey estimated that about 6 percent of U.S. adults are experiencingsymptoms associated with long COVID, including brain fog, fatigue, depression, and sleep problems.
Past studies have shown that patients with obstructive sleep apnea (OSA) tend to have more severe illness when initially infected with COVID-19. OSA affects about1 in 8adults but is often underdiagnosed.
To better understand links between sleep apnea and long-term COVID symptoms, the research team reviewed data across three RECOVER research networks of patients who had tested positive for COVID-19 between March 2020 and February 2022, according to their health records.
Two networks included adult patients the National Patient-Centered Clinical Research Network (PCORnet) with 330,000 patients and the National COVID Cohort Collaborative (N3C) with 1.7 million patients. The third patient cohort in the study analysis included the pediatric-focused network PEDSnet, made up of 102,000 children.
Published online on May 11 in the journalSleep,this study found that a prior diagnosis of sleep apnea in the PCORnet group came with a 12 percent increase in risk for long-term symptoms months after patients initial infections.
In the N3C patient group, in which patients had higher levels of other chronic conditions than those in PCORnet, sleep apnea came with a 75 percent increase in risk for long COVID compared to those without sleep apnea.
The observed increases in risk for long COVID in adults with sleep apnea remained significant even when the research team accounted for obesity, hypertension, diabetes, and hospitalization at the time of their initial COVID infection, all known to independently contribute to risk for long COVID.
The researchers hypothesize that the differences in the percentage increases in long COVID risk between the study groups may be further explained by variations indefinitionsof long COVID, study populations, and in analysis methods of patient records, across the large study.
In contrast to the patterns seen in adults, the contribution of sleep apnea to the risk of long COVID disappeared in children when the researchers controlled for other risk factors, including obesity.
A strength of the work is that the link between sleep apnea and long COVID persisted regardless of how the researchers in our study defined long COVID or gathered data,says senior study author Lorna Thorpe, PhD, MPH, Professor and Director of the Division of Epidemiology at NYU Langone Health.
She is also co-lead of efforts to understand long COVID using electronic health record networks for the RECOVER CSC at NYU Langone.
This study is the first collaboration of this focus and scale to find that adults with sleep apnea are at greater risk for long COVID.
RECOVERResearching COVID to Enhance Recoveryis dedicated to understanding why some people develop long-term symptoms following a COVID infection, and how to detect, treat, and prevent long COVID. As the CSC, NYU Langone Health is charged with integrating research activities of clinical sites around the country.
Theres still so much to uncover about long COVID, but this study will inform clinical care by identifying patients that should be watched more closely, says corresponding author Hannah Mandel, a senior research scientist for the electronic health record studies arm of the RECOVER CSC at NYU Langone Health.
People with sleep apnea who get infected with COVID should seek early treatment, pay attention to their symptoms, and keep up with their vaccinations to lower the risk of infection in the first place.
Interestingly, in the N3C study group, long COVID risk was higher among women with sleep apnea compared to men with sleep apnea.
Investigators identified an 89% increased likelihood for having long COVID in women, compared to a 59% increased chance for men.
The reasons for this are not clear, butwomenwith diagnosed sleep apnea in their medical records may have more severe conditions than men, in part because women with sleep apnea tend to go undiagnosed with OSA for longer.
Funding: The study was funded by RECOVER (OT2HL161847) and received additional support from the National Center for Advancing Translational Sciences (UL1TR002494).
For more information on RECOVER, visithttps://recovercovid.org.
Author: Gregory WilliamsSource: NYU LangoneContact: Gregory Williams NYU LangoneImage: The image is credited to Neuroscience News
Original Research: Open access.Risk of post-acute sequelae of SARS-CoV-2 infection associated with pre-coronavirus disease obstructive sleep apnea diagnoses: an electronic health recordbased analysis from the researching coronavirus disease to enhance recovery initiative by Lorna Thorpe et al. SLEEP
Abstract
Risk of post-acute sequelae of SARS-CoV-2 infection associated with pre-coronavirus disease obstructive sleep apnea diagnoses: an electronic health recordbased analysis from the researching coronavirus disease to enhance recovery initiative
Study Objectives
Obstructive sleep apnea (OSA) has been associated with more severe acute coronavirus disease-2019 (COVID-19) outcomes. We assessed OSA as a potential risk factor for Post-Acute Sequelae of SARS-CoV-2 (PASC).
Methods
We assessed the impact of preexisting OSA on the risk for probable PASC in adults and children using electronic health record data from multiple research networks. Three research networks within the REsearching COVID to Enhance Recovery initiative (PCORnet Adult, PCORnet Pediatric, and the National COVID Cohort Collaborative [N3C]) employed a harmonized analytic approach to examine the risk of probable PASC in COVID-19-positive patients with and without a diagnosis of OSA prior to pandemic onset. Unadjusted odds ratios (ORs) were calculated as well as ORs adjusted for age group, sex, race/ethnicity, hospitalization status, obesity, and preexisting comorbidities.
Results
Across networks, the unadjusted OR for probable PASC associated with a preexisting OSA diagnosis in adults and children ranged from 1.41 to 3.93. Adjusted analyses found an attenuated association that remained significant among adults only. Multiple sensitivity analyses with expanded inclusion criteria and covariates yielded results consistent with the primary analysis.
Conclusions
Adults with preexisting OSA were found to have significantly elevated odds of probable PASC. This finding was consistent across data sources, approaches for identifying COVID-19-positive patients, and definitions of PASC. Patients with OSA may be at elevated risk for PASC after SARS-CoV-2 infection and should be monitored for post-acute sequelae.
More:
Increased Long-Covid Risk for Those With Sleep Apnea - Neuroscience News
- Neuroscience helps explain the teenage brain and mental health - ABC News - September 15th, 2024 [September 15th, 2024]
- XX Marks the Spot: Addressing Sex Bias in Neuroscience - The Scientist - September 15th, 2024 [September 15th, 2024]
- Neuroscience-based tools for transformative leadership - Fast Company - September 15th, 2024 [September 15th, 2024]
- How 100 Years of EEG Have Transformed Neuroscience - Being Patient - September 15th, 2024 [September 15th, 2024]
- Reconstructing dopamines link to reward - The Transmitter: Neuroscience News and Perspectives - September 15th, 2024 [September 15th, 2024]
- The neuroscience of itch in relation to transdiagnostic psychological approaches - Nature.com - September 15th, 2024 [September 15th, 2024]
- A README for open neuroscience - The Transmitter: Neuroscience News and Perspectives - September 15th, 2024 [September 15th, 2024]
- Dopamine and the need for alternative theories - The Transmitter: Neuroscience News and Perspectives - September 15th, 2024 [September 15th, 2024]
- Kim Stachenfeld on the dance between neuroscience and artificial intelligence - The Transmitter: Neuroscience News and Perspectives - September 15th, 2024 [September 15th, 2024]
- Vijay Mohan K. Namboodiri - The Transmitter: Neuroscience News and Perspectives - September 15th, 2024 [September 15th, 2024]
- Varied Cognitive Training Boosts Learning and Memory - Neuroscience News - September 15th, 2024 [September 15th, 2024]
- Issue | September 2024 | XX Marks the Spot: Addressing Sex Bias in Neuroscience - The Scientist - September 15th, 2024 [September 15th, 2024]
- The Transmitter Partners With World Wide Neuro and Brain Inspired, Building on Mission to Inform, Connect Neuroscience Community - StreetInsider.com - September 15th, 2024 [September 15th, 2024]
- Gene Therapy Offers Hope for Glaucoma and AMD - Neuroscience News - September 15th, 2024 [September 15th, 2024]
- The Neuroscience of Phantom Sensations: Can We Feel Whats Not Really There? - SciTechDaily - September 2nd, 2024 [September 2nd, 2024]
- Tau May Protect Brain Cells from Oxidative Damage - Neuroscience News - September 2nd, 2024 [September 2nd, 2024]
- Scientists use fainting to uncover new insights into the neuroscience of consciousness - PsyPost - September 2nd, 2024 [September 2nd, 2024]
- Biosensors and being fearless with Lin Tian - The Transmitter: Neuroscience News and Perspectives - September 2nd, 2024 [September 2nd, 2024]
- Can Neuroscience Train Your Brain to Be Happier? This Startup Has an App for That - Inc. - September 2nd, 2024 [September 2nd, 2024]
- Neuroscience Surprise: Different Types of Love Light Up Different Parts of the Brain - SciTechDaily - September 2nd, 2024 [September 2nd, 2024]
- Second paper from lab of Nobel Prize winner to be retracted - The Transmitter: Neuroscience News and Perspectives - September 2nd, 2024 [September 2nd, 2024]
- How cognitive bias affects your draft strategy with neuroscience professor Dr. Renee Miller - Yahoo Sports - August 5th, 2024 [August 5th, 2024]
- This 3-step approach to performance reviews uses neuroscience to make them less awful - Fast Company - August 5th, 2024 [August 5th, 2024]
- Is it time to worry about brain chimeras? - The Transmitter: Neuroscience News and Perspectives - August 5th, 2024 [August 5th, 2024]
- Sharing brain images can foster new neuroscience discoveries - American Heart Association - July 26th, 2024 [July 26th, 2024]
- Latest News: Neuroscience Major Applies What Shes Learned in the Classroom and in the Lab - Muhlenberg College - July 26th, 2024 [July 26th, 2024]
- BioIVT to Highlight its Integral Role in Drug and Diagnostic Discovery and Development in addition to Neuroscience Research at Premier Life Science... - July 26th, 2024 [July 26th, 2024]
- Alto Neuroscience Receives Funding Award from Wellcome Trust to Accelerate Development of ALTO-100 in Bipolar Depression Leveraging Precision... - July 26th, 2024 [July 26th, 2024]
- Neuroscience Says 3 Simple Steps Can Turn Disappointment and Stress Into Success and Fulfillment (and Boost Your Emotional Intelligence) - Inc. - July 26th, 2024 [July 26th, 2024]
- Golf: neuroscience reveals the secrets of better putting new study - The Conversation - July 26th, 2024 [July 26th, 2024]
- The Neuroscience Behind Video: Why Video is the Most Effective Marketing Channel - StreamTV Insider - July 26th, 2024 [July 26th, 2024]
- Building an autism research registry: Q&A with Tony Charman - The Transmitter: Neuroscience News and Perspectives - July 26th, 2024 [July 26th, 2024]
- Adjusting Proteins Increases Ozempics Effectiveness - Neuroscience News - July 18th, 2024 [July 18th, 2024]
- Low-Calorie Diets Harm Athletes Performance and Health - Neuroscience News - July 18th, 2024 [July 18th, 2024]
- Reflective Thinking Boosts Teen Brain Resilience to Violence - Neuroscience News - July 18th, 2024 [July 18th, 2024]
- Neuroscience Says Olympians Like Simone Biles Use the Autopilot Trick to Achieve Peak Performance. So Can You - Inc. - July 18th, 2024 [July 18th, 2024]
- What well-being is (and isnt), according to neuroscience - Big Think - July 18th, 2024 [July 18th, 2024]
- Brain Areas Take Micro-Naps While the Rest Stays Awake - Neuroscience News - July 18th, 2024 [July 18th, 2024]
- Persistent protein pairing enables memories to last - The Transmitter: Neuroscience News and Perspectives - July 18th, 2024 [July 18th, 2024]
- AI Enhances Story Creativity but Risks Reducing Novelty - Neuroscience News - July 18th, 2024 [July 18th, 2024]
- Infection Brain Inflammation Triggers Muscle Weakness - Neuroscience News - July 18th, 2024 [July 18th, 2024]
- Alto Neuroscience, Inc. (NYSE:ANRO) Receives Average Rating of Buy from Analysts - Defense World - July 18th, 2024 [July 18th, 2024]
- 2024 Kavli Prize awarded for research on face-selective brain areas - The Transmitter: Neuroscience News and Perspectives - June 18th, 2024 [June 18th, 2024]
- Unlocking Flow: The Neuroscience of Creative Bliss - Neuroscience News - April 15th, 2024 [April 15th, 2024]
- Revolutionizing Glioblastoma Treatment - Neuroscience News - April 15th, 2024 [April 15th, 2024]
- Decoding spontaneous thoughts from the brain via machine learning - EurekAlert - April 15th, 2024 [April 15th, 2024]
- Reducing Toxic AI Responses - Neuroscience News - April 15th, 2024 [April 15th, 2024]
- Advancing the neuroscience of human pregnancy - Nature.com - April 15th, 2024 [April 15th, 2024]
- Angela Bryan Awarded Hazel Barnes Prize | Psychology and Neuroscience - University of Colorado Boulder - April 15th, 2024 [April 15th, 2024]
- How Old Are You in Your Head? The Neuroscience of Subjective Age Reveals How to Stay Mentally Young - Inc. - April 15th, 2024 [April 15th, 2024]
- Biohaven Showcases Innovative Neuroscience Portfolio with 20 Presentations at the 2024 American Academy of ... - PR Newswire - April 15th, 2024 [April 15th, 2024]
- Those Who Use Willpower Deemed More Trustworthy - Neuroscience News - April 15th, 2024 [April 15th, 2024]
- How Sex and Gender Shape Our Cognition - Neuroscience News - April 15th, 2024 [April 15th, 2024]
- War's Toll on the Brain: Widespread PTSD and Anxiety Among Ukrainians - Neuroscience News - April 15th, 2024 [April 15th, 2024]
- Paints and Pesticides Linked to ALS Risk - Neuroscience News - April 15th, 2024 [April 15th, 2024]
- AI STORIES: A New Vision for AI and Narratives - Neuroscience News - April 15th, 2024 [April 15th, 2024]
- Neuroscience Breakthrough Unveils How We Learn and Remember - SciTechDaily - April 15th, 2024 [April 15th, 2024]
- Pregnancy's Toll: Accelerated Aging in Young Mothers - Neuroscience News - April 15th, 2024 [April 15th, 2024]
- Learning and Memory Formation's Molecular Basis - Neuroscience News - April 15th, 2024 [April 15th, 2024]
- Acetaminophen in Pregnancy Not Linked to Autism, ADHD Risk - Neuroscience News - April 15th, 2024 [April 15th, 2024]
- Childhood Loneliness Linked to Later Psychosis - Neuroscience News - April 15th, 2024 [April 15th, 2024]
- Vigil Neuroscience, Inc. (NASDAQ:VIGL) Expected to Post Q1 2024 Earnings of ($0.58) Per Share - Defense World - March 29th, 2024 [March 29th, 2024]
- International Brain Research Organisation (IBRO) Diversity Grants 2024 Opportunity Desk - Opportunity Desk - March 29th, 2024 [March 29th, 2024]
- Hereditary Alzheimer's Transmitted Via Bone Marrow Transplants - Neuroscience News - March 29th, 2024 [March 29th, 2024]
- Household Chemicals Linked to Brain Health Risks - Neuroscience News - March 29th, 2024 [March 29th, 2024]
- Cheers to Longevity: Couples Who Drink Together, Live Longer - Neuroscience News - March 29th, 2024 [March 29th, 2024]
- Sleeplessness Makes You Feel Up To Ten Years Older - Neuroscience News - March 29th, 2024 [March 29th, 2024]
- Aging Brain Cells Have Prolonged Death Process - Neuroscience News - March 29th, 2024 [March 29th, 2024]
- Anxiety Drives Wishful Thinking to Risky Levels - Neuroscience News - March 29th, 2024 [March 29th, 2024]
- Prolonged Progestogen Use Linked to Brain Tumor Risk - Neuroscience News - March 29th, 2024 [March 29th, 2024]
- The Genetic Secrets of Neuron Formation - Neuroscience News - March 29th, 2024 [March 29th, 2024]
- Vigil Neuroscience Reports Fourth Quarter and Full Year 2023 Financial Results and Provides Business Update - Yahoo Finance - March 29th, 2024 [March 29th, 2024]
- Big research, little time: Medical neuroscience student wins 3 Minute Thesis finals - Dal News - March 29th, 2024 [March 29th, 2024]
- The new NeuroAI - Nature.com - March 29th, 2024 [March 29th, 2024]
- Exploring Aphantasia: The Mind Without a Mental Picture - Neuroscience News - March 29th, 2024 [March 29th, 2024]
- Altered Brain pH Linked to Cognitive Disorders - Neuroscience News - March 29th, 2024 [March 29th, 2024]
- Emotion vs. Reason: Rethinking Decision-Making - Neuroscience News - March 29th, 2024 [March 29th, 2024]
- DNA Damage and Inflammation Key to Memory Formation - Neuroscience News - March 29th, 2024 [March 29th, 2024]
- Embracing Neurodiversity: Beyond Stigma to Strength - Neuroscience News - March 29th, 2024 [March 29th, 2024]
- Devil in the Details: The Visual World of Prosopometamorphopsia - Neuroscience News - March 29th, 2024 [March 29th, 2024]