Glenner, G. G. & Wong, C. W. Alzheimers disease: initial report of the purification and characterization of a novel cerebrovascular amyloid protein. Biochem. Biophys. Res. Commun. 120, 885890 (1984).
Article CAS PubMed Google Scholar
van Dyck, C. H. et al. Lecanemab in early Alzheimers disease. N. Engl. J. Med. 388, 921 (2023).
Article PubMed Google Scholar
Mintun, M. A. et al. Donanemab in early Alzheimers disease. N. Engl. J. Med. 384, 16911704 (2021).
Article CAS PubMed Google Scholar
Serrano-Pozo, A., Aldridge, G. M. & Zhang, Q. Four decades of research in Alzheimers disease (19752014): a bibliometric and scientometric analysis. J. Alzheimers Dis. 59, 763783 (2017).
Article PubMed PubMed Central Google Scholar
Corder, E. H. et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimers disease in late onset families. Science 261, 921923 (1993).
Article CAS PubMed Google Scholar
Farrer, L. A. et al. Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium. JAMA 278, 13491356 (1997).
Article CAS PubMed Google Scholar
Corder, E. H. et al. Protective effect of apolipoprotein E type 2 allele for late onset Alzheimer disease. Nat. Genet. 7, 180184 (1994).
Article CAS PubMed Google Scholar
Reiman, E. M. et al. Exceptionally low likelihood of Alzheimers dementia in APOE2 homozygotes from a 5,000-person neuropathological study. Nat. Commun. 11, 667 (2020).
Article CAS PubMed PubMed Central Google Scholar
Mattsson, N. et al. Prevalence of the apolipoprotein E 4 allele in amyloid positive subjects across the spectrum of Alzheimers disease. Alzheimers Dement. 14, 913924 (2018).
Article PubMed Google Scholar
Belloy, M. E. et al. APOE genotype and Alzheimer disease risk across age, sex, and population ancestry. JAMA Neurol. 80, 12841294 (2023).
Article PubMed PubMed Central Google Scholar
Granot-Hershkovitz, E. et al. APOE alleles association with cognitive function differs across Hispanic/Latino groups and genetic ancestry in the study of Latinos investigation of neurocognitive aging (HCHS/SOL). Alzheimers Dement. 17, 466474 (2021).
Article CAS PubMed Google Scholar
Rajabli, F. et al. Ancestral origin of ApoE 4 Alzheimer disease risk in Puerto Rican and African American populations. PLoS Genet. 14, e1007791 (2018).
Article PubMed PubMed Central Google Scholar
Blue, E. E., Horimoto, A. R. V. R., Mukherjee, S., Wijsman, E. M. & Thornton, T. A. Local ancestry at APOE modifies Alzheimers disease risk in Caribbean Hispanics. Alzheimers Dement. 15, 15241532 (2019).
Article PubMed Google Scholar
Griswold, A. J. et al. Increased APOE 4 expression is associated with the difference in Alzheimers disease risk from diverse ancestral backgrounds. Alzheimers Dement. 17, 11791188 (2021).
Article CAS PubMed Google Scholar
Nuytemans, K. et al. Identifying differential regulatory control of APOE 4 on African versus European haplotypes as potential therapeutic targets. Alzheimers Dement. 18, 19301942 (2022).
Article CAS PubMed Google Scholar
Fortea, J. et al. APOE4 homozygosity represents a distinct genetic form of Alzheimers disease. Nat. Med. 30, 12841291 (2024).
Article CAS PubMed Google Scholar
Qian, J. et al. APOE-related risk of mild cognitive impairment and dementia for prevention trials: an analysis of four cohorts. PLoS Med. 14, e1002254 (2017).
Article PubMed PubMed Central Google Scholar
Stites, S. D. et al. Patients asking about APOE gene test results? Heres what to tell them. J. Fam. Pract. 71, E1E7 (2022).
PubMed PubMed Central Google Scholar
Wightman, D. P. et al. A genome-wide association study with 1,126,563 individuals identifies new risk loci for Alzheimers disease. Nat. Genet. 53, 12761282 (2021).
Article CAS PubMed PubMed Central Google Scholar
Bellenguez, C. et al. New insights into the genetic etiology of Alzheimers disease and related dementias. Nat. Genet. 54, 412436 (2022).
Article CAS PubMed PubMed Central Google Scholar
Huq, A. J. et al. Polygenic score modifies risk for Alzheimers disease in APOE 4 homozygotes at phenotypic extremes. Alzheimers Dement. 13, e12226 (2021).
Google Scholar
Ebenau, J. L. et al. Risk of dementia in APOE 4 carriers is mitigated by a polygenic risk score. Alzheimers Dement. 13, e12229 (2021).
Google Scholar
Erickson, C. M. et al. KLOTHO heterozygosity attenuates APOE4-related amyloid burden in preclinical AD. Neurology 92, e1878e1889 (2019).
Article CAS PubMed PubMed Central Google Scholar
Belloy, M. E. et al. Association of klotho vs heterozygosity with risk of Alzheimer disease in individuals who carry APOE4. JAMA Neurol. 77, 849862 (2020).
Article PubMed PubMed Central Google Scholar
Neitzel, J. et al. KL-VS heterozygosity is associated with lower amyloid-dependent tau accumulation and memory impairment in Alzheimers disease. Nat. Commun. 12, 3825 (2021).
Article CAS PubMed PubMed Central Google Scholar
Ali, M. et al. Leveraging large multi-center cohorts of Alzheimer disease endophenotypes to understand the role of klotho heterozygosity on disease risk. PLoS ONE 17, e0267298 (2022).
Article CAS PubMed PubMed Central Google Scholar
Huq, A. J. et al. Genetic resilience to Alzheimers disease in APOE 4 homozygotes: a systematic review. Alzheimers Dement. 15, 16121623 (2019).
Article PubMed Google Scholar
Serrano-Pozo, A. & Growdon, J. H. Is Alzheimers disease risk modifiable? J. Alzheimers Dis. 67, 795819 (2019).
Article PubMed PubMed Central Google Scholar
Jaisa-Aad, M., Muoz-Castro, C. & Serrano-Pozo, A. Update on modifiable risk factors for Alzheimers disease and related dementias. Curr. Opin. Neurol. 37, 166181 (2024).
Article PubMed Google Scholar
Kolli, A. et al. Interactions between the apolipoprotein E4 gene and modifiable risk factors for cognitive impairment: a nationally representative panel study. BMC Geriatr. 22, 938 (2022).
Article CAS PubMed PubMed Central Google Scholar
Langella, S. et al. Effect of apolipoprotein genotype and educational attainment on cognitive function in autosomal dominant Alzheimers disease. Nat. Commun. 14, 5120 (2023).
Article CAS PubMed PubMed Central Google Scholar
Park, S.-Y. et al. Modifying effects of race and ethnicity and APOE on the association of physical activity with risk of Alzheimers disease and related dementias. Alzheimers Dement. 19, 507517 (2023).
Article CAS PubMed Google Scholar
Jia, J. et al. Association between healthy lifestyle and memory decline in older adults: 10 year, population based, prospective cohort study. Br. Med. J. 380, e072691 (2023).
Article Google Scholar
Park, S.-Y. et al. Racial and ethnic differences in the population-attributable fractions of Alzheimer disease and related dementias. Neurology 102, e208116 (2024).
Article PubMed Google Scholar
Lee, M. et al. Variation in population attributable fraction of dementia associated with potentially modifiable risk factors by race and ethnicity in the US. JAMA Netw. Open 5, e2219672 (2022).
Article PubMed PubMed Central Google Scholar
Arboleda-Velasquez, J. F. et al. Resistance to autosomal dominant Alzheimers disease in an APOE3 Christchurch homozygote: a case report. Nat. Med. 25, 16801683 (2019).
Article CAS PubMed PubMed Central Google Scholar
He, K. Y. et al. Characterization of APOE Christchurch carriers in 455,306 UK Biobank participants. Mol. Neurodegener. 18, 92 (2023).
Article PubMed PubMed Central Google Scholar
Wardell, M. R., Brennan, S. O., Janus, E. D., Fraser, R. & Carrell, R. W. Apolipoprotein E2-Christchurch (136 ArgSer). New variant of human apolipoprotein E in a patient with type III hyperlipoproteinemia. J. Clin. Invest. 80, 483490 (1987).
Article CAS PubMed PubMed Central Google Scholar
Pocovi, M. et al. Incomplete dominance of type III hyperlipoproteinemia is associated with the rare apolipoprotein E2 (Arg136Ser) variant in multigenerational pedigree studies. Atherosclerosis 122, 3346 (1996).
Article CAS PubMed Google Scholar
Hernandez, I. et al. Heterozygous APOE Christchurch in familial Alzheimers disease without mutations in other Mendelian genes. Neuropathol. Appl. Neurobiol. 47, 579582 (2021).
Article CAS PubMed Google Scholar
Le Guen, Y. et al. Association of African ancestry-specific APOE missense variant r145c with risk of Alzheimer disease. JAMA 329, 551560 (2023).
Article PubMed PubMed Central Google Scholar
Medway, C. W. et al. ApoE variant p.V236E is associated with markedly reduced risk of Alzheimers disease. Mol. Neurodegener. 9, 11 (2014).
Article PubMed PubMed Central Google Scholar
Le Guen, Y. et al. Association of rare APOE missense variants V236E and R251G with risk of Alzheimer disease. JAMA Neurol. 79, 652663 (2022).
Article PubMed PubMed Central Google Scholar
Liu, C.-C. et al. APOE3-Jacksonville (V236E) variant reduces self-aggregation and risk of dementia. Sci. Transl. Med. 13, eabc9375 (2021).
Article CAS PubMed PubMed Central Google Scholar
Boyle, P. A. et al. Person-specific contribution of neuropathologies to cognitive loss in old age. Ann. Neurol. 83, 7483 (2018).
Article CAS PubMed PubMed Central Google Scholar
Bennett, D. A. et al. Amyloid mediates the association of apolipoprotein E e4 allele to cognitive function in older people. J. Neurol. Neurosurg. Psychiatry 76, 11941199 (2005).
Article CAS PubMed PubMed Central Google Scholar
Mungas, D., Tractenberg, R., Schneider, J. A., Crane, P. K. & Bennett, D. A. A 2-process model for neuropathology of Alzheimers disease. Neurobiol. Aging 35, 301308 (2014).
Article CAS PubMed Google Scholar
Serrano-Pozo, A., Qian, J., Monsell, S. E., Betensky, R. A. & Hyman, B. T. APOE2 is associated with milder clinical and pathological Alzheimer disease. Ann. Neurol. 77, 917929 (2015).
Article CAS PubMed PubMed Central Google Scholar
Goldberg, T. E., Huey, E. D. & Devanand, D. P. Association of APOE 2 genotype with Alzheimers and non-Alzheimers neurodegenerative pathologies. Nat. Commun. 11, 4727 (2020).
Article CAS PubMed PubMed Central Google Scholar
Goldberg, T. E., Huey, E. D. & Devanand, D. P. Associations of APOE 2 genotype with cerebrovascular pathology: a postmortem study of 1275 brains. J. Neurol. Neurosurg. Psychiatry https://doi.org/10.1136/jnnp-2020-323746 (2020).
Yu, L. et al. APOE and cerebral amyloid angiopathy in community-dwelling older persons. Neurobiol. Aging 36, 29462953 (2015).
Follow this link:
Multifaceted roles of APOE in Alzheimer disease - Nature.com
- GWAS of multiple neuropathology endophenotypes identifies new risk loci and provides insights into the genetic risk of dementia - Nature.com - October 13th, 2024 [October 13th, 2024]
- Fibrin drives thromboinflammation and neuropathology in COVID-19 - Nature.com - September 2nd, 2024 [September 2nd, 2024]
- Senolytics show promise in combating brain aging and COVID-19 ... - News-Medical.Net - November 18th, 2023 [November 18th, 2023]
- Startling discovery at Great Salt Lake could lead to damaging health ... - FOX 13 News Utah - November 18th, 2023 [November 18th, 2023]
- Senolytic therapies suppress long COVID in human organoids ... - BioWorld Online - November 18th, 2023 [November 18th, 2023]
- Eight scientists among most-cited researchers in world - Mirage News - November 18th, 2023 [November 18th, 2023]
- UW study links past military service to Alzheimer's disease - University of Wisconsin School of Medicine and Public Health - November 18th, 2023 [November 18th, 2023]
- Study reveals no neuroinflammation in long COVID patients with ... - News-Medical.Net - November 18th, 2023 [November 18th, 2023]
- Work complexity linked to better cognitive aging | National Institute ... - National Institute on Aging - November 18th, 2023 [November 18th, 2023]
- Hussman Institute Celebrates Banner Year at Global Human ... - University of Miami - November 18th, 2023 [November 18th, 2023]
- What happens in your brain when your head gets hit? - Cosmos - May 13th, 2023 [May 13th, 2023]
- Bioengineered Protein May Prevent COVID Infections and Improve ... - Feinberg News Center - May 13th, 2023 [May 13th, 2023]
- My Fathers Brain: Life in the Shadow of Alzheimers - Next Big Idea Club Magazine - May 13th, 2023 [May 13th, 2023]
- Scholarship for the PhD in Medical Sciences in the field of Pathology ... - Times Higher Education - May 13th, 2023 [May 13th, 2023]
- Variation along P2RX7 interacts with early traumas on severity of ... - Nature.com - May 13th, 2023 [May 13th, 2023]
- How to Treat Dementia No Matter What Age You Are - DISCOVER Magazine - May 13th, 2023 [May 13th, 2023]
- UC Irvine study shows traffic-related air pollution in Irvine weakens ... - EurekAlert - May 13th, 2023 [May 13th, 2023]