As the star of the show, it makes sense that Ellen Pompeo has spent time reflecting on her favorite "Grey's Anatomy" moments. During an interview with Entertainment Tonight, the actress revealed two of her top picks. Surprisingly, both take place in Season 2. The first happens in the season premiere, "Raindrops Keep Falling on My Head," which picks up right where the previous season left off. The narrative primarily centers around Meredith Grey and Derek Shepherd's (Patrick Dempsey) break up after the unexpected arrival of his wife, Addison Forbes Montgomery (Kate Walsh). Despite the dramatic revelation, Cristina Yang (Sandra Oh) isn't doing so well, either. She's trying to work through her tangled relationship with Preston Burke (Isaiah Washington), a situation complicated by the fact that she's pregnant.

Cristina's one true love is her work, so she decides to get an abortion. After the dust settles, Cristina and Meredith take a minute to evaluate their lives. Cristina admits that she needed to designate an emergency contact person, so she gave them Meredith's name. "You're my person," she tells Meredith, which has remained one of Pompeo's favorite interactions (via YouTube). It's a line that the characters repeat back to each other frequently, a concise expression of love that perfectly sums up their friendship. The scene confirms what the first season showed: No matter what challenges come their way, Meredith and Cristina will always stick together.

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Ellen Pompeo Dishes On Her Pick For The Best Grey's Anatomy Moment Of All Time - Looper