This was a surprisingly difficult list to write, not just because there have been an awful lot of couples in Grey's Anatomy over the last 15 years, but also because a lot of those relationships were so perfect that we couldn't really imagine them being with anyone else. Imagine splitting up Meredith and Derek, for example!
RELATED: Grey's Anatomy: 5 Friendships We Would Have Loved To Have Seen (& 5 We Don't Care About)
However, despite the medical drama's impressive track record, there have been a few couples that fans weren't exactly too keen about. Other characters have been incredibly unlucky in love and so it's about time that changes. Here are 10 couples that would have made a lot of sense but never got together.
These two were absolutely adorable together and their friendship remains one of the highlights of Grey's Anatomy. This pairing originally started as a one night stand, as Callie was depressed about the deterioration of her relationship with George, who wasn't treating her particularly well.
Mark offered his services to Callie, who accepted, and then felt incredibly guilty afterward. Despite this, though, the two soon became firm friends with benefits, but their relationship never went any further than physical attraction. Mark and Callie were such good friends, that a relationship between the two would have seemed almost natural. They even share a daughter together.
These two became friends after Lexie discovered that George was repeating his intern year and she agreed to keep his secret. As a result, they grew closer and even rented an apartment together, that George christened the 'crapartment', because it was so, you know...less than.
RELATED: Grey's Anatomy: Top 10 Fan-Favorite Characters, Ranked
However, Lexie's constant optimism balanced out George's negativity, and she even helped him realize that things weren't as bad as they seemed. George then became a happier person. Honestly, these two were very cute together and would have made an adorable, awkward little couple.
Many people might be wondering why we've included this entry on the list. To explain, we must refer back to the beginning of Season 14, when it was discovered that Amelia had a benign (but absolutely massive) tumor pressing down on her brain. It was revealed that she had had this tumor for around 10 years.
Struggling to come to terms with what this meant for her, both personally and professionally, Amelia entered a brief spiral of doubt, with DeLuca helping her process everything. Even after her operation, DeLuca was there to comfort her and help her heal. If these two ever became a couple, they would be so supportive of one another.
Izzie and Jackson never really interacted during their time on the show together. Which is fair enough if you think about it, as Izzie left Grey's Anatomy soon after Jackson joined. They didn't even have enough time to become friends. However, we think that if they had been given a chance, they could have made a pretty decent couple.
RELATED: Grey's Anatomy: 6 Romances That Ended Too Soon (& 4 That Didn't End Soon Enough)
Izzie was very cheerful and full of hope, bordering on naive. She always looked out for her patients and advocated for them well but she had a habit of becoming easily attached. When Jackson first arrived, he was arrogant and cocksure. The two could have helped each other to become better surgeons and better people in general.
To a lot of people, the mere fact that Meredith and Alex were even considered to be on this list is the highest form of sacrilege. Be that as it may, Meredith and Alex are now extremely close and have been arguably since before Cristina actually left Grey Sloan Memorial to jet off to Switzerland.
Meredith hasn't really found anyone to be with since Derek died and so it's no exaggeration to say that Alex is probably the most important man in her life. As for Alex himself, he does have Jo, but the way he interacts with Mer makes one think that there could be something between these two best friends. Or maybe it's just wishful thinking.
These two have actually slept together on Grey's Anatomy, but seeing as how Derek is Amelia's big brother, Mark wisely went no further than a casual booty call. However, Mark did date Lexie, who was Derek's little sister-in-law, so really, there is no excuse as to why Amelia and Mark didn't get together beforehand.
RELATED: Grey's Anatomy: 10 Hilarious Patient Memes Only True Fans Will Understand
Amelia is known for being a little crazy and that has made her come across as slightly annoying to both characters in, and fans of, Grey's Anatomy. However, I always liked Amelia and she and Mark would have been such a great fit together. They're both hilarious people who can take a joke, but they are also serious, talented professionals.
This is another friendship between two people who should have taken it to the next level. Certainly, in later seasons, Callie and Owen became closer as they went through divorces and disasters and began collaborating on innovative medical projects. They weren't without their disagreements (this is Owen after all) but they always had each other's backs.
In Season 11, they were designing prosthetic limbs to help soldiers who had been injured in the line of duty. Their enthusiasm and teamwork was fun to watch, and they could both have a laugh together. We're sort of glad these two didn't get together, as who knows what would have happened to Callie, but it's fun to imagine what these two would have been like as a couple.
Teddy has been through the mother of all wringers when it comes to her love life. She has loved Owen, who used her as and when he saw fit; the hospital psychologist, whose job meant he couldn't settle down; Henry, who was adorable but died, and Tom, who was dumped for Teddy's baby daddy, Owen.
RELATED: Grey's Anatomy: 5 Times Cristina Was Meredith's Best Friend (& 5 Times It Was Alex)
Essentially, what we're saying is that, with the exception of Henry, Teddy is too good for all these men. She needs someone who will treat her right and will respect her opinions and choices. Link has already proven that he is a good man and if he weren't with Amelia and a possible baby, we're pretty sure that he and Teddy would make an excellent couple.
Maggie is a great character. She's intelligent, friendly and she gets on well with her colleagues, The one thing that Maggie has always been rubbish at, though, is love. Finding love, being in love, anything to do with love and Maggie the Confident crumbles away into Maggie the Awkward and Obsessed.
However, Tom is the complete opposite. He's casual, very witty and very charming. If he and Maggie got together, Maggie might second doubt everything, as is her MO, but he is probably the only person in Grey Sloan who would encourage Maggie to relax and just have a bit of fun. Maggie would also help to soften Tom and help him to get along with his peers.
We cannot stress this one enough. Despite there being so many strong and confident women in Grey's Anatomy, the only two women Owen Hunt seemingly can't get enough of are Teddy and Amelia. It beggars belief. The worst thing is is that Owen has treated both women terribly in the past and yet they still give him multiple chances.
Owen's relationship with Amelia wasn't all his fault, to be fair, as Amelia kept on backing out 6 or 7 times a day. However, Amelia got better and they resumed their relationship, only for Owen to act like a complete jerk. It was the same with Teddy. Owen only wanted her when she was unavailable and was jealous of any partner she had.
NEXT: Grey's Anatomy: The Main Characters, Ranked By Intelligence
Next10 Hit Sitcoms From The 80's That Wouldn't Fly Today
Ben Pettitt is a recent English graduate of the University of Nottingham. He loves to write, read and watch Netflix. This is one of the reasons why he decided to come and display his knowledge of pop culture as a writer for Screen Rant.
See more here:
Grey's Anatomy: 10 Couples That Would Have Made A Lot Of Sense (But Never Got Together) - Screen Rant
- 19 Most Memorable (and Heart-Wrenching!) 'Grey's Anatomy' Episodes of All Time - PEOPLE - March 30th, 2025 [March 30th, 2025]
- 16 stars you forgot were on Grey's Anatomy before their big break (including future Oscar nominees) - Entertainment Weekly News - March 30th, 2025 [March 30th, 2025]
- "I Cried When He Died": Shonda Rhimes Is Still Deeply Impacted By Killing One Grey's Anatomy Character - Screen Rant - March 30th, 2025 [March 30th, 2025]
- See the Best Greys Anatomy Behind-the-Scenes Photos to Celebrate 20 Years of the Medical Drama - PEOPLE - March 30th, 2025 [March 30th, 2025]
- Katherine Heigl, Jeffrey Dean Morgan reunite to talk Grey's Anatomy , from Denny's death to ghost sex - Entertainment Weekly News - March 30th, 2025 [March 30th, 2025]
- Sandra Oh Is Changing Her Tune on a Potential Return to 'Grey's Anatomy' - PEOPLE - March 30th, 2025 [March 30th, 2025]
- The Scrapped Grey's Anatomy Spin-Off Would Have Ruined The Show's Best Characters - SlashFilm - March 30th, 2025 [March 30th, 2025]
- Anatomy of a flood: The Derna tragedys lessons for Libyan governance - Brookings Institution - March 30th, 2025 [March 30th, 2025]
- 19 Years Later, Shonda Rhimes Still Isnt Over This Greys Anatomy Death (and Neither Are We) - Collider - March 30th, 2025 [March 30th, 2025]
- The perfect palliative balm of Greys Anatomy - Financial Times - March 30th, 2025 [March 30th, 2025]
- 15 Behind-the-Scenes Facts You Didn't Know About Grey's Anatomy, 20 Years After It Premiered - MSN - March 30th, 2025 [March 30th, 2025]
- I Have Zero Endings: Shonda Rhimes Has No Idea How (or When) Greys Anatomy Will End - Collider - March 30th, 2025 [March 30th, 2025]
- My Only Allegiance Is to the Story: Shonda Rhimes Explains Why Shes Killed So Many Beloved Greys Anatomy Characters - Collider - March 30th, 2025 [March 30th, 2025]
- 'Grey's Anatomy' star Ellen Pompeo says $20 million salary brings 'true independence': 'I don't have to do anything I don't want to do' - CNBC - March 30th, 2025 [March 30th, 2025]
- 'I love your song from "Grey's Anatomy"': How the ABC medical drama's soundtrack changed these artists' musical careers - Yahoo... - March 30th, 2025 [March 30th, 2025]
- Shonda Rhimes On The 'Grey's Anatomy' & 'Scandal' Spinoffs That Never Materialized: "We Thought About A Lot Of Things" - Deadline - March 30th, 2025 [March 30th, 2025]
- Shades of Gray in Twenty Years of Greys Anatomy - Books, Health and History - March 30th, 2025 [March 30th, 2025]
- Linda Lowy talks casting Shondaland, from Grey's Anatomy to the best audition she's ever seen - Entertainment Weekly News - March 30th, 2025 [March 30th, 2025]
- Shonda Rhimes is 'forever bitter' about having to fight for 'Grey's Anatomy' musical episode - Entertainment Weekly News - March 30th, 2025 [March 30th, 2025]
- Greys Anatomy: Is It Finally Time for Owen & Teddy to Call it Quits? (POLL) - TV Insider - March 30th, 2025 [March 30th, 2025]
- After 18 Years, Meredith Finally Proves Ellis' Most Hurtful Criticism Wrong In Grey's Anatomy Season 21 - Screen Rant - March 30th, 2025 [March 30th, 2025]
- Arte France Boards Movistar Plus+s The Anatomy of a Moment, From The Plagues Alberto Rodrguez - Variety - March 30th, 2025 [March 30th, 2025]
- Makes Me Just Go, Hmm: Christinas Potential Greys Anatomy Return Addressed By Sandra Oh, Who Admits Her Stance Has Softened After Years Of Hard No -... - March 30th, 2025 [March 30th, 2025]
- Shonda Rhimes Reveals "A Bunch" Of Never Made Grey's Anatomy Spinoffs, Including One Based On The Shepherd Family - Screen Rant - March 30th, 2025 [March 30th, 2025]
- Anatomy of a Massacre - by Theo Padnos - Persuasion - Persuasion | Yascha Mounk - March 30th, 2025 [March 30th, 2025]
- We Thought About a Lot of Things: Shonda Rhimes Discusses Greys Anatomy Spin-Offs That Never Were - Collider - March 30th, 2025 [March 30th, 2025]
- 'Grey's Anatomy' Redefined the Medical Drama on TV - Collider - March 30th, 2025 [March 30th, 2025]
- Greys Anatomy turns 20: How Katherine Heigl pulled off her Emmy upset and remains the only series regular to win - Gold Derby - March 30th, 2025 [March 30th, 2025]
- Why Shonda Rhimes Scrapped Spinoffs of Greys Anatomy and Scandal - TheWrap - March 30th, 2025 [March 30th, 2025]
- Greys Anatomy at 20: From their pretty exciting first day to their linchpin episodes, Chandra Wilson and James Pickens Jr. look back - Gold Derby - March 30th, 2025 [March 30th, 2025]
- 'Grey's Anatomy': Deceit Rocks Grey Sloan, Link and Jo Make a Big Decision and Meredith Faces the Wrath of Richard - PEOPLE - March 15th, 2025 [March 15th, 2025]
- Ellen Pompeo won't let 10-year-old watch Grey's Anatomy , isn't ready for her to see her in her underwear on TV - Entertainment Weekly News - March 15th, 2025 [March 15th, 2025]
- Ellen Pompeo Reveals Why She Doesn't Want Her 10-Year-Old Daughter Sienna to Watch Grey's Anatomy - PEOPLE - March 15th, 2025 [March 15th, 2025]
- How to watch Greys Anatomy' online for FREE without cable - PennLive - March 15th, 2025 [March 15th, 2025]
- Forget Marry Me Chicken: Links Insane Greys Anatomy Breakfast Sandwich Is the Real Deal-Closer - TVLine - March 15th, 2025 [March 15th, 2025]
- Original Grey's Anatomy Cast in Photos: Then and Now - Good Housekeeping - March 15th, 2025 [March 15th, 2025]
- Why Ellen Pompeo Wont Let Her 10-year-old Daughter Watch Greys Anatomy - Hollywood Reporter - March 15th, 2025 [March 15th, 2025]
- Ellen Pompeo's Good American Family Promos Airing During ABC's Grey's Anatomy Night Is Kind Of Trippy, But Her New Hulu Show Has Me Intrigued -... - March 15th, 2025 [March 15th, 2025]
- Ellen Pompeo explains why she doesnt want her 10-year-old daughter watching Greys Anatomy - New York Post - March 15th, 2025 [March 15th, 2025]
- Grey's Anatomy Season 21 Episode 10 Review: I'm So Glad Meredith Is Back In A Refreshing Return To Form For The ABC Show - Screen Rant - March 15th, 2025 [March 15th, 2025]
- Grey's Anatomy Showrunner Weighs In On The Pitt's Success & The Competition In Medical Drama - Screen Rant - March 15th, 2025 [March 15th, 2025]
- Ellen Pompeo on Stepping Back From 'Grey's Anatomy' to Take on Natalia Grace's Story (Exclusive) - Entertainment Tonight - March 15th, 2025 [March 15th, 2025]
- Ellen Pompeo Reveals Hilarious Reason She Wont Let Her Daughter Watch Greys Anatomy - E! Online - E! NEWS - March 15th, 2025 [March 15th, 2025]
- 10 of the Biggest Feuds in Greys Anatomy History - Shondaland.com - March 15th, 2025 [March 15th, 2025]
- Anatomy of a Recession Update: Consumer confidence | Franklin Templeton - Beyond Bulls & Bears - March 15th, 2025 [March 15th, 2025]
- Ellen Pompeo Says 'Grey's Anatomy' Fans Will Be Shocked By Her Role as Natalia Grace's Adoptive Mom - Access Hollywood - March 15th, 2025 [March 15th, 2025]
- A Guide to Security Investments: The Anatomy of a Cyberattack - SecurityWeek - March 15th, 2025 [March 15th, 2025]
- Noah Wyle Says His Kids Have Watched More Greys Anatomy Than ER : Its a Point of Contention (Exclusive) - PEOPLE - March 15th, 2025 [March 15th, 2025]
- Welcome from Head of Department of Anatomy and Neuroscience - News | University College Cork - March 15th, 2025 [March 15th, 2025]
- Greys Anatomy Showrunner Reveals Whether Ellen Pompeo Will Return for Season 22 - Collider - March 15th, 2025 [March 15th, 2025]
- Grey's Anatomy Season 21 Sneakily Continues A Key Station 19 Story A Year After ABC Canceled The Spinoff - Screen Rant - March 15th, 2025 [March 15th, 2025]
- Anatomy of the average American paycheck - Floyd Chronicle & Times - March 15th, 2025 [March 15th, 2025]
- Grey's Anatomy Showrunner Addresses Whether There Could Be A Future Without Any Meredith Grey - Screen Rant - March 15th, 2025 [March 15th, 2025]
- Greys Anatomy Actor Jason George Explains What Its Like Filming Amidst Schmitt And Yasudas Departure - CinemaBlend - March 15th, 2025 [March 15th, 2025]
- The Magic Behind 'Grey's Anatomy': CGI, Medical Expertise, and Hollywood Tricks - Collider - March 5th, 2025 [March 5th, 2025]
- Canadians and Wayne Gretzky: Anatomy of a Relationship on Thin Ice - The New York Times - March 5th, 2025 [March 5th, 2025]
- Spits & Suds: The Anatomy of how trade deadline deals get done in the NHL - 105.3 The Fan - March 5th, 2025 [March 5th, 2025]
- 'Grey's Anatomy' Star Kate Walsh Shares Healthy Habits for Cancer Prevention - Healthline - March 5th, 2025 [March 5th, 2025]
- The Anatomy of Fear: Tips on Scoring a Body Horror Movie - No Film School - March 5th, 2025 [March 5th, 2025]
- Go-to anatomy atlas featuring corpses of Nazi victims revamped by UCLA cardiologist - The Times of Israel - March 5th, 2025 [March 5th, 2025]
- Ellen Pompeo Reveals Which Viral Scene from Greys Anatomy Made Her Oldest Daughter Cry (Exclusive) - PEOPLE - March 5th, 2025 [March 5th, 2025]
- In Karnataka, the anatomy of three riot-like situations - The Hindu - March 5th, 2025 [March 5th, 2025]
- Ellen Pompeo Reveals The Grey's Anatomy's Episode That Made Her Oldest Daughter Cry - Screen Rant - March 5th, 2025 [March 5th, 2025]
- Heres Whats New on TV This Week Including Grey's Anatomy American Idol, The Righteous Gemstones, and More - Collider - March 5th, 2025 [March 5th, 2025]
- Greys Anatomy cast members who have spoken out about their own serious health conditions - Tyla - March 5th, 2025 [March 5th, 2025]
- Greys Anatomy Returns: Everything You Need to Know Ahead of the Midseason Premiere - TVLine - March 5th, 2025 [March 5th, 2025]
- All the Lingering Questions We Need Answered When Greys Anatomy Comes Back - Shondaland.com - March 5th, 2025 [March 5th, 2025]
- Greys Anatomy star Kate Walsh shares important message after being diagnosed with brain tumour - Tyla - March 5th, 2025 [March 5th, 2025]
- 'I Couldn't Hold It Together': Ellen Pompeo Recalls Grey's Anatomy Moment That Brought Her and Her Daughter to Tears - CBR - March 5th, 2025 [March 5th, 2025]
- Greys Anatomy star Kate Walsh reveals very subtle warning sign ahead of brain tumour diagnosis - Tyla - March 5th, 2025 [March 5th, 2025]
- Grey's Anatomy season 21 part 1 recap: All to remember before part 2 arrives - Sportskeeda - March 5th, 2025 [March 5th, 2025]
- Grey's Anatomy Season 21 Episode 9: Release date & time, what to expect, and more - Sportskeeda - March 5th, 2025 [March 5th, 2025]
- The Splendour of Life, Starring Anatomy of a Fall Actor Camille Rutherford, Picked Up by H264 (EXCLUSIVE) - Variety - February 25th, 2025 [February 25th, 2025]
- Greys Anatomy Sneak Peek: Its Tears for Fears in Your First Look at the Midseason Premiere - TVLine - February 25th, 2025 [February 25th, 2025]
- Can a Longtime Greys Anatomy Stan Learn to Love the Grim Medical Reality of The Pitt? - Vogue - February 25th, 2025 [February 25th, 2025]
- Greys Anatomy Is Coming Back Next MonthHeres What We Know About That Cliff-Hanger - Glamour - February 25th, 2025 [February 25th, 2025]
- New Extremity Box Set Collects 'High Tension,' 'Anatomy of Hell,' 'Frontier(s),' 'Martyrs' on Blu-ray - Bloody Disgusting - February 25th, 2025 [February 25th, 2025]
- When Does 'Grey's Anatomy' Return With New Episodes? - TV Insider - February 25th, 2025 [February 25th, 2025]
- Books of Discovery Expands Access to Premier Anatomy and Physiology Textbooks for Educators and Students - EIN News - February 25th, 2025 [February 25th, 2025]
- 10 Scenes That Made Grey's Anatomy Fans Quit the Show (& Never Look Back) - CBR - February 25th, 2025 [February 25th, 2025]