There are many things to love about Drs. Meredith Grey and Cristina Yang. For ten seasons, Meredith and Cristina's relationshipwas as central toGrey's Anatomyas any romantic entanglements. Both women have complicated relationships with their profession and the men they date. From their first year as interns to working as attendings to co-owning the hospital, the pair are a driving force behind the series events.

While the Twisted Sisters have one of the strongest bonds in television history, there are numerous instances when Meredith and Cristina are selfish and let each other down. The two start in direct competition, and bond accordingly. Despite their devout support for each other, there are plenty of instances when Meredith and Cristina's friendship makes no sense!

Inthe pilot episode, Meredith and Cristina mark each other as "the one to beat." Neither are warm, touchy-feely women, but they know how to get through the tough stuff. Cristina utters the infamous lines, "You're my person," when listing Meredith as her emergency contact, summarizing their friendship as a fact rather than a choice.

Meredith tampers with the Alzheimer's trial at Richard's insistence, and Alex reveals to the chief of surgery, Owen Hunt. Though Meredith forgives the future pediatric surgeon, Cristina takes her anger at Alex to a whole new level. Her apathy towards Karev never really goes away, and Meredith does little to dissuade her watch-dog.

One of the biggest fights between the inseparable Dr. Yang and Dr. Grey is in season ten when Cristina tells Meredith that she is the lesser doctor due to her devotion to her husband and children. The criticism is cold and not the way a friend tells you something important. She doesn't say this only once.

Cristina grew up wealthy in Beverly Hills, theliteral opposite climate of Minnesota. She complains about the weather in Seattle. The choice to move to Mayo Clinic from Seattle Grace seems driven by spite, which would explain why Meredith and Cristina go so long without talking in season nine.

Meredith and Cristina related to each other in a particular way,but the plane crash tests their bond in season eight. Each processed thecatastrophic incident differently, but Cristina never fully recovered. She tried to get back to work in a state of reactive psychosis, and only Owencould help her.

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It seems odd when giving your children a sentimental name not to honor your best friend. Viewers understand Meredith naming her son after Dr. Miranda Bailey, who worked through an intense fear of ORs todeliverMeredith's son and repair the internal bleeding. Meredith names her youngest daughter Ellis, an homage to hermotherand their fraught relationship.

Cristinasays no when Meredithasks her to share in something special because "everyone poops on the birthing table." The topic of children is causing tension between her and Owen, which probably contributed to her response. Still, it was sad to see Meredith rejected in one of the times she makes herself vulnerable.

As interns, Cristina and Meredithdate attendings. Dr. Preston Burke leaves Cristina at the altar; Meredith and Derek have a dramatic relationship up to their eventual Post-It marriage. Meredith never gets past Owen's PTSD episode, where he strangles Cristina. Cristina's final words to Meredith dismiss Derek and remind her she is the sun.

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Early in the series, Preston Burke develops a tremor in his hand after getting shot, which leads to Cristina performing operations beyond her year and her having to eventually reveal the truth to Chief Webber. When Derek is recovering from an injury, she pushes him to operate before he's ready.

Cristina chalks upMeredith's presence in the program to nepotism. She wants to be a surgeonaftera car accidentkilled her father when she was nine. She felthisheart stop beating. Her assumption of nepotism dismisses the complicated relationship Meredith has with her mother, who tried to kill herself in front ofher five-year-old daughter and openly disrespects Meredith until her death.

The six survivors of the plane crash sue the hospital to ensure no one experience what they did. To save the hospital from bankruptcy, the doctors co-invest with the Harper Avery (now Catherine Fox) Foundation tobuy the renamed hospital. They find out this disqualifiesthe surgical team from winning Harper Avery awards, which drives Cristina to leave Grey+Sloan Memorial and Meredith.

Whenthe Twisted Sistersread Ellis' diaries from her days at Seattle Grace, Meredith remarks the resemblance of Cristina's drive and temperament to her mother. This is when she starts to like her mother. While intended as a compliment in many ways, it's clear that Cristina also possesses many of Ellis's less desirable qualities.

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Meredith's friend from her drinking-in-Europe-days, Sadie, comes to Seattle Grace and disrupts the hospital ecosystem. She leads a group of defiant interns experimenting and performing medical procedures on one another. When Dr. Webber finds out, he blames Cristinaand Meredith not only fails to defend her, and she insults Cristina.

Bombs in a body cavity. A mass shooting at the hospital. A plane crash. Meredith and Cristina have faced death so many times,once simultaneouslyperforming life-saving operations on each other's husbands. Other squabblesseem trivialafter almost dying together so many times.

Meredith panics because she says she is notoriously bad with parents, citing her mother as an example. Cristina may tell Meredith "that she is the sun," but when it came to meeting Derek's mother for the first time, she didn't take out Meredith's ridiculous bright pink scrunchie around her high ponytail. Friends encourage friends to be themselves!

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Maki Zatychies graduated from the University of Guelph with an honours degree in English, minor in Creative Writing and a master's in creative non-fiction. All things out of her mouth connect back to pop culture, literature and media. Jeopardy! is the gospel and Alex Trebek her lord and saviour. She can be found at home, in her hobbit hole, sipping tea and demanding writing support from her Rex rabbit, Sawyer.

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