With the departure of yet another fan-favorite character, viewers are discussing again what they would like to see when Greys Anatomy finallycomes to a close. While we dont know how or whenEllen Pompeo,Shonda Rhimes, andKrista Vernoffplan to end the show, what we do know is how many fans would hate to see it happen.

When the series went onwinter breakin late November, we left off with Jo Wilson (Camilla Luddington) attempting to adopt a Safe Haven baby who was dropped off at Station 19. However, her husband, Alex Karev (Justin Chambers), did not make an appearance on the midseason finale episode.

On Friday, Jan. 10, 2020, Chambers announced he was leaving the show, which is now in its 16th season. His departure is what spawned the intense talk about the show ending.

Theres no good time to say goodbye to a show and character thats defined so much of my life for the past 15 years, Chambers statement to USA Today read.

Chambers cited his reason for leaving as wanting to take on new and different roles in his career.

For some time now, however, I have hoped to diversify my acting roles and career choices. And, as I turn 50 and am blessed with my remarkable, supportive wife and five wonderful children, now is that time, the statement continued.

With his departure, the show will now be down to only three original cast members; Pompeo, James Pickens, Jr. and Chandra Wilson.

Greys Anatomy should end soon, and it should end with Meredith sitting in a home, and a pretty black woman is sitting with her talking to her, and Meredith is like Are you the doctor? And Zola is like No mom, but I am a doctor,' wrote the fan.

Then Merediths like I think I was a doctor once,' continued the Twitter user. And Zola hands her a ton of notebooks which she starts to read and its her journals from when she was a doctor before she got Alzheimers, and all of the writings are the monologues she says in every episodes beginning.

The original tweet received 124,700 likes and 16,900 retweets. Many fans agreed that they would like to see the show end with Meredith also getting Alzheimers disease, like her mother. However, a good amount of fans were also appalled at the idea of Dr. Grey ending up like that.

So many Greys fans want it to end this way, and I would be sooooo pissed if it did,wrote one Twitter userin disagreement. After EVERYTHING they put her through, giving her Alzheimers would just be wrong. I get that it makes perfect sense for the storyline, but still. Let her be happy for once.

Although many fans liked the original tweet, some feel that it would be awful to add one more tragic thing to Merediths life.

Nope, absolutely not, added another fan. If they end her story with Alzheimers, I will scream.

Many users on Reddit also agree that they do not want the show to end this way.

That would be the most predictable ending at this point, wrote anotherviewer on Reddit.

Several Redditors commented on the same thing. If Meredith has Alzheimers, it would be extremely predictable. Although most fans believe it is time for the show to end, no one is in agreement on how it might end.

It sounds like only Pompeo, Rhimes and Vernoff know the answer to that one. You can catch the midseason premiere of Greys Anatomy Thursday, Jan. 23, 2020, at 9 p.m. ET.

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'Grey's Anatomy': Fans Argue Over a Controversial Possible Ending to the Show - Showbiz Cheat Sheet