After leaving "Grey's Anatomy" in 2016, Sara Ramirez continued their career as an actor. Their first significant role after "Grey's" was their main role as Kat Sandoval in the political drama "Madam Secretary" for the show's fourth and fifth seasons from 2017 to 2019 (via IMDb). Additionally, from 2012 to 2018, Ramirez voiced the role of Queen Miranda in the animated children's series "Sofia the First."

A couple of years after "Madam Secretary" ended, Ramirez landed another leading role on the highly anticipated HBO Max sequel series to "Sex and the City," titled "And Just Like That ..." In the series, Ramirez plays Che Diaz, a nonbinary queer comedian who hosts a podcast alongside Carrie Bradshaw (Sarah Jessica Parker). After being introduced to Miranda Hobbes (Cynthia Nixon) by Carrie, the two begin a romance even though Miranda is still married. By the end of the series, Miranda has left her marriage and has decided to move to Los Angeles with Che.

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What Happened To Sara Ramirez After Leaving Grey's Anatomy? - Looper