All posts by medical

Bruker expands optical microscopy portfolio with Luxendo deal – Optics.org

12May2017

Acquisition of Heidelberg-based spin-out from the European Molecular Biology Laboratory should aid optogenetics, embryology, and other cutting-edge applications.

The US-headquartered microscope company Bruker has acquired Luxendo, a recent spin-out from the European Molecular Biology Laboratory (EMBL) that has developed a low-phototoxicity system based on light-sheet fluorescence.

Based in Heidelberg, Germany, Luxendo had raised 8million in venture finance as recently as January, saying that it needed the funds to expand sales, marketing and servicing activity related to its proprietary single plane illumination microscopy (SPIM) instruments after experiencing higher-than-expected demand from both academic and industrial customers.

The SPIM technology, which is equipped with two sCMOS cameras, is based around an inverted optical setup and comes with customizable laser illumination at up to eight different wavelengths.

The twin advantages of the approach, compared with regular laser scanning confocal microscopes, are that sampling time and phototoxicity and therefore damaging side effects to living specimens are both greatly reduced.

Luxendos microscopes are able to offer lower phototoxicity by only illuminating a sequential stack of thin slices of the organism being viewed at any one time.

This technology allows scientists to observe living organisms for extended periods of time without them being adversely impacted by phototoxicity, stated the firm previously.

Embryology to optogenetics For Bruker, the deal for an undisclosed sum represents the latest move to update its microscopy portfolio with innovative optical techniques aimed at applications such as live cell imaging and super-resolution microscopy.

In 2014 the Billerica, Massachusetts, firm acquired the University of Utah spin-out Vutara, whose research team had developed a 3D super-resolution technique based around a relatively powerful laser source.

And late last year Bruker commercialized an all-optical holographic module for stimulating and imaging multiple neurons in neural networks, targeting the fast-growing and high-profile market for optogenetics research.

Luxendos CEO Andreas Pfuhl says that light-sheet microscopy is revolutionizing the field of biological imaging, with the EMBL spin-out playing an influential role in its adoption for live-sample studies.

We feel that our history with EMBL has given us unique insights into what bio-imaging researchers need both right now and in the near future, he said. We are very gratified to join an internationally esteemed instrumentation company like Bruker, whose philosophy, culture and reputation so closely align with our research-oriented goals.

Much of the microscope development took place at EMBL, under the leadership of the labs cell biology and biophysics chief Lars Hufnagel, before Luxendo was founded in September 2015.

Portfolio transformation The SPIM microscopes are expected to improve Bruker's existing portfolio of swept-field confocal, super-resolution, and multiphoton fluorescence microscope product lines, enabling new research advances in small organism embryology, live-cell imaging, brain development and cleared brain tissue, and optogenetics applications.

This acquisition is another important step forward in Bruker's portfolio transformation, states the company, with Mark Munch, president of the Bruker NANO division, adding:

With its strong intellectual property position and unique SPIM technology, Luxendo has quickly established itself in the light-sheet microscopy market, particularly in Europe.

He adds that, like the Vutara acquisition, the new capabilities will provide synergies with the firms current microscopy products. We feel that we can take the business to the next level in both global market reach and next-generation development, which should greatly benefit our life sciences research customers, he said.

EMBLs director general Iain Mattaj added: It has been very rewarding to witness the rapid trajectory from pioneering technology developed at EMBL to Luxendo's well-designed, robust microscopes, and now this acquisition.

We anticipate that Bruker, with its excellent reputation in providing innovative technology, will make SPIM even more widely available. It will be truly exciting to see what the larger biological research community will discover with light-sheet microscopy.

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Bruker expands optical microscopy portfolio with Luxendo deal - Optics.org

Grey’s Anatomy recap: ‘True Colors’ – EW.com (blog)

Let this be a lesson to all of us when Shonda Rhimes says a season finalewill be on fire, shes not kidding around. As in, were gonna go into next weeks episode with the hospital actually ON FIRE.

And leave it to Greys to have a literal explosion not be the only shocker of the night. Lets just scrub in and get right to all of it

Alex tracks down Jos husband Alex Karev has a particular set of skills, and hell use them to locate the abusive estranged husband youre hiding from and fantasize about punching him in the face. Alex has indeed found Dr. Paul Stadler (Glee alum Matthew Morrison) and is lurking around the hotel where hes attending a medical conference, conflicted as to whether he should approach the guy and what he should do. First, he imagines chatting Paul up at the hotel bar, introducing himself with a fake last name and getting drunk with him before throwing punches at him outside. But that daydream ends with police sirens and Alex in jail, and nobody wants to worry about him getting arrested again (raise your hand if you were glad that was just imaginary, because Im right there with you).

Then, he imagines doing his best Liam Neeson/Taken impression to the guy before he gives a speech at the conference, casually walks over, and warns that hes watching him, and how if he ever goes near Jo again, hell find him and kill him. That scenario also takes a nightmare turn when he imagines coming back to Seattle to find Paul strangling her. (Raise your hand if you were glad that was imaginary, too.)

But then we see the non-imaginary, no-one-dies-or-gets-arrested scenario play out: Paul cuts in front of Alex on the street to get a cab, then apologizes and offers to share it, if hes heading to the airport as well. Our dear Dr. Karev stares at him, but ultimately doesnt say anything about Jo and lets the cab drive away. Much less dramatic, but is this the last well see of the two of them in the same place?

Owens shocking sister newsWhen Owen gets a knock at the door and two Army officers are waiting outside, it doesnt look like the news is good. And at first, we think it isnt all we hear is that its news about his sister, and then Owen goes into work in a shell-shocked daze. When a mother tearfully thanks him for stopping their baby daughter from choking, hes abrupt and non-Owen-like with them and walks off. Amelia sees this and goes after him, and once theyre alone in one of the supply closets, he tells her theyve found his sister alive.

He tells her Megan Hunt was found in a basement in a rebel-held neighborhood and shes now in an Army hospital in Germany. Hes still in shock and cant bring himself to believe its really her, and Amelia calmly says theyll find out for sure.

After getting on the phone with Dr. Altman (Teddy! Kim Raver!) and showing off some impressive conversational German Amelia learns Megan is being transferred to the U.S. and asks if she can be brought to Grey Sloan once shes stateside. She also tells Owen shes called a PTSD expert, not just for Megan, but for him as well.

For Owen, the news his sister is alive and coming home has him wracked with guilt. He thinks about how he got married, divorced, and married again, going on with his life for the past 10 years while she was being held captive and tortured. I stopped looking, he says, breaking into tears in Amelias arms. I gave up.

What does Megans return mean for Mer and Riggs? Well, Mer had just decided to take another huge step with Riggs letting him meet her children and sleep over for part of the night when she comes home to Amelia sitting with a sleeping Owen on the couch. Amelia tells her about his sister being alive and how shell be arriving in Seattle in the next few days, and Meredith asks if Riggs knows yet. He doesnt, because Owen hasnt told anyone else yet, not even his own parents. Mer decides she has to tell him immediately because if Derek were alive, shed want to know as soon as possible.

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Grey's Anatomy recap: 'True Colors' - EW.com (blog)

Anatomical Gifts Program will honor donors at service – The Dartmouth

by Debora Hyemin Han | 5/12/17 2:05am

The Geisel School of Medicine'sAnatomical Gifts Program will hold a memorial service on May 25.

Source: Courtesy of James Reed

While technology and computer simulations have become more efficacious in modeling the human body, many medical schools continue the tradition of using human cadavers for anatomical instruction. Dartmouths Geisel School of Medicine is just one of the schools that continue to place value on cadaver-based teaching, and each spring, Geisels Anatomical Gifts Program conducts a memorial service honoring the anatomical donors whose bodies are used in the first-year anatomy class.

According to director of the anatomy laboratory James Reed, Geisel first-years take three terms of anatomy before they finish the first year, working in small groups on one cadaver throughout that time. Reed said that using human bodies to teach anatomy is the best way to teach the subject, as it allows students to examine normal human variation something that simulations have yet to truly emulate. He said that it is important for students to know not only the standard structures of the human body, but also whether a deviation from that standard structure is actually normal human variation or pathology, which is best learned by interacting with actual bodies.

The Anatomical Gifts Program, overseen by Geisels Department of Anatomy, receives applications from donors who reside in and pass away in New Hampshire and Vermont to be included in the anatomical lab, according to Reed. There are 1,600 bodies in Geisels program currently, and the average age of the donors at death is in the mid 80s, though the donors may be as young as 21 as long as they die of natural causes. The program requires that donors bodies be intact namely, that they do not die of traumatic accident or have an autopsy post-death and do not have infectious or rare diseases. In addition, because Reed and Anatomical Gifts Program administrative director Hanna Riendeau embalm the bodies, the donors must not have had vascular issues and circular diseases or have undergone recent surgeries. Reed said that in order to protect the dignity of the donors, anatomical tissue is not transported outside the facility once they arrive.

Reed said that most donors participate in the program for altruistic reasons, such as giving back to Dartmouth. The program has accepted Dartmouth alumni, former professors and former doctors from Dartmouth-Hitchcock Hospital and Veterans Affairs in the past. This year, Reed said there was a high number of local people who signed up to be in the program, exemplifying how strong the Dartmouth-Upper Valley connection is. He noted that this strong connection is one reason why Geisel has not had to outsource for cadavers very often.

Briana Goddard Med20, who interviewed donors families in preparation for the memorial service, said that many said the donors had a love of education and wanted to help contribute to medical education.

Diana Funk Med20 said that knowing that the people who are in the program truly wanted to be there was what allowed her to overcome the initial shock of working on a human body.

That was really [a] meaningful sentiment that I think helped a lot of people through their initial fear and grief: knowing that every single one of them wanted to be there to teach us, she said.

John Damianos 16 Med20 agreed that he had to strike a balance between respecting the humanity of the donors who may still have living family members and being cognizant that the donors made the conscious decision to be teachers even after death. Damianos said that knowing the donors desired to be used for the purpose of teaching allowed him to avoid being too gingerly in dissecting the bodies.

He added that the medical school made a concerted effort to put the cadaver-based instruction into perspective, especially as it fits into the larger medical journey, through sessions on the psychology of illness and a panel on the anatomical donations. The panel included a retired Geisel faculty member whose body will be donated to the Anatomical Gifts Program once he passes.

During the panel, Damianos said it was impressed upon him and his peers that the donor is their first patient, that the body is not just cells, tissues and organs to dissect, but a person with scars and tattoos, and whose brains were formed by the memories and experiences they had in their lifetime. According to Riendeau, students are given the names of the donors as well as a brief background, which gives students context for their subjects.

Damianos said incorporating the different bio-psycho-social factors of the patient into the class emphasized that medicine is a humanistic science. Furthermore, he said that the class has changed his view on medicine in the pedagogical realm.

Pre-med education trains you to think that medicine is a science, but its really not theres science in medicine and theres biomedical sciences, but medicine in itself is an art and a practice. When you look at pre-med education curriculum, you dont see that, he said. [In organic chemistry there is] always an answer, [and in] cell [biology] theres always an answer. But the one remarkable thing about anatomy is that each body is different.

Funk added that working on human bodies has demonstrated that much of the study of medicine relies on what is handed down from person to person, whether that be information or tangible bodies. She said that knowing that this is the type of scheme that she and her peers are a part of made her feel connected to the people who came before and after her. She also said she realized the importance of actually touching and feeling body parts in studying medicine.

Damianos echoed a similar statement, saying that holding a brain in his hands was the most impactful part of the process.

To actually hold a human brain in my hands this is the brain that is formed by this persons experiences and emotions, this brain enabled them to speak, enabled them to love, enabled them to cry that just blew my mind, he said.

To commemorate the impact the donors have had on the students studies and medical journeys, and to meet the families of the donors, first-year students plan and conduct a memorial service each year. Funk and Goddard are preparing reflections from families of donors and students, and Damianos will perform with the a cappella group the Dermatones, along with other student performers at the service.

Reed said that the group extends invitations to everyone who has been in the lab throughout the year in order to express the gratitude of the entire community to the donors families.

He also said that this service provides closure for the families that have been delayed for up to two years, given that they do not bury their loved one as most people do.

Its not the typical end of life procedure; youre not triggering what would be considered the societal norm of having a large funeral with a casket, Reed said.

Through the reflections, Funk said she and her peers hope to juxtapose the students reflections on what the learning experience meant to them with who the donors were in their lifetimes and how excited they were to be a part of the program. She said that knowing that every person in the program had specifically intended their bodies not just to go to science, but also to the Geisel anatomy program in particular was meaningful.

Hopefully [this] will bring together the families and the students in a way that they can be mutually grateful for each other, Funk said.

The Anatomical Gifts Program will hold its service at Rollins Chapel on May 25 at 5 p.m. The event is open to the entire Dartmouth community.

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Anatomical Gifts Program will honor donors at service - The Dartmouth

UCD Professor Receives Prestigious US Award for Physiology Research – Irish Medical News

Professor Cormac Taylor was the first ever non-US based recipient of the Takeda Distinguished Research Award, presented by the American Physiological Society (APS), since its establishment in 2007.The prestigious award is presented annually, by the Societys Gastrointestinal and Liver Physiology Section, to an outstanding investigator who has been internationally recognised for his/her contribution to physiological research in these areas.

Professor Taylor is a Professor of Cellular Physiology at UCDs School of Medicine and a Fellow of UCD Conway Institute and was presented with the award during the 2017 APS Experimental Biology meeting held this week in Chicago.

He leads a UCD research group investigating the mechanisms by which epithelial cells respond to low oxygen levels (hypoxia). The group explores the regulation of gene expression in hypoxic conditions and the potential of targeting oxygen-sensitive cellular pathways in inflammation as a means of treating conditions such as inflammatory bowel disease (IBD).

Professor Cormac Taylor said: I am delighted and honoured to receive the 2017 Takeda Distinguished Researcher Award. This Award, which underscores the importance of investigator-led basic research in medicine, is a testament to the hard work of the PhD students and postdocs who have trained in my lab at University College Dublin over the last number of years.Founded in 1887, the APS was the first US society in the biomedical sciences field and it currently represents more than 10,500 members, publishing 15 peer-reviewed journals that are read worldwide.

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UCD Professor Receives Prestigious US Award for Physiology Research - Irish Medical News

Laila Ali on hand for grand opening of HealthPartners’ new Neuroscience Center – KMSP-TV

ST. PAUL, Minn. (KMSP) - LailaAli grew up watching her father's Parkinson's Disease progress.

Her father, of course, was legendary boxer Muhammad Ali, who died less than a year ago.

Since then, she's become an advocate for those with neurological diseases, and was on hand Wednesday for the grand opening ofHealthPartner'sNeuroscience Center in St. Paul.

She says it's just the sort of place families dealing with neurological conditions deserve.

"You have so many questions that you need answers to," she said. "It takes a whole village really. I think it gives comfort in knowing this is a place right here in their home town they can go to."

From the track helping people walk across the room to the pool equipment with monitors for rehabilitation work, dozens of doctors are at work even now, treating various brain disorders--but being under the same roof as the lab conducting as many as 30 research studies at any given time is what makes the Center a destination.

The building cost more than 70 million dollars, warranting a fundraising campaign to assist the hospital. The goal is to reach 10.5 million by the end of 2017.

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Laila Ali on hand for grand opening of HealthPartners' new Neuroscience Center - KMSP-TV

Pairing business and neuroscience – Penn Current

Led by Penn Integrates Knowledge Professor Michael Platt, the Wharton Neuroscience Initiative is a deliberate mash-up of neuroscience and business, with the intention of exploring every domain in which the two can inform each other.

At first, business and neuroscience might seem like animprobable pair. So when Penn launched its WhartonNeuroscience Initiative, WiN for short, its distinctivenessspurred particular attention: How exactly do thetwo fields coincide?

Its shocking and provocative, says Michael Platt,the programs founding director. But thats exactlywhat we aim to be. The Wharton Neuroscience Initiativeis a deliberate mash-up of neuroscience and business,and our intention is to explore every domain inwhich these two can inform each other.

WiN launched this past September, and opened itsbright, new space in Steinberg-Dietrich Hallrightnext to the Wharton Behavioral Labjust before winterbreak.

Its led by Platt, a Penn Integrates Knowledge professorwith appointments in the departments of Neuroscience,Psychology, and Marketing, and ElizabethJohnson, WiNs executive director and senior fellow.The duo worked for more than a decade together atDuke University before coming to Penn last year. KateMolt, who formerly worked in Whartons marketing department,serves as the programs coordinator.

Wharton is not your grandfathers school of financeanymore, Platt says. Just as it has put majorinvestments into analytics and innovation, Whartonknows neuroscience will be key to the practice in thenext decade.

The relationship often comes down to decisionmakingsomething the business community spends alot of time thinking about.

But we know relatively little about the biologicalmechanisms that underlie decision-making, says Johnson,a neuroscientist by training. Although there havebeen great strides made in the last 15 years in that capacity,it hasnt moved into the realm of applicationyet.

Platt continues, We are finally in a position to applythat knowledge in a much more real-world environment,to real-world questions that have impact. Whatwas a dream 20 years ago can now be achieved.

WiNs goal isnt to turn Wharton students into neuroscientists.Its more about developing a common language.

You have to have a lingua franca in order to evenbegin to have creative applications emerging out of thiscommunity, Johnson says. You have to have a sense ofopen communication between disciplines, which thisforum provides.

Some early faculty affiliates include the AnnenbergSchool for Communications Emily Falk, whose workpredicts behavior change after exposure to persuasivemessages; the Wharton Schools Gideon Nave, whostudies the biological basis for how humans make decisions;the School of Engineering and Applied SciencesDanielle Bassett, who uses tools from network scienceand complex systems theory to enhance understandingof connectivity in the brain; and the School of Arts &Sciences Coren Apicella, who analyzes the evolutionaryorigins of social behaviors.

The Initiative hopes to amplify the academichomes of its faculty members, as well as students, Johnsonsays.

I think situating this kind of initiative at a universitywhere its a walking campus in an urban landscape,where the schools of medicine, law, business, arts andsciences, even vet, are all right here, is an incredibleasset, she says. It encourages movement into an intellectualspace like Wharton, where they may not havefelt was their home before.

As WiN continues to develop its presence on campus,it hopes to be a place for related educationitsalready spearheading new coursesand abundant researchopportunities.

We hope to bolster the educational andresearch platform to make it possible to dointegrative research thats both vertical andhorizontal, Johnson explains. By vertical Imean undergraduates all the way throughfaculty, but even more vertical to includeoutside partners from industry and thecorporate world, and by horizontal I meanfrom across many different disciplines.

A big part of WiNs plans is also to sponsorregular, open-to-the-public events. Itsalready coordinated a half-day conferencethis past December, focused on the interactionsbetween brain science and marketing.

Philadelphia is such a hub of activityfor us, and we want to engage with the communityat large, Johnson says. It will onlyincrease what we are capable of doing.

Originally published on Thursday, May 11, 2017.

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Pairing business and neuroscience - Penn Current

University initiative focuses on behavioral science to tackle campus challenges – Princeton University

A new University initiative is bringing together researchers and administrators to apply insights from behavioral science to tackle campus challenges and advance research in that field.

Representatives from 24 administrative units and seven academic departments, programs and centers gathered in March to launch the Campus Behavioral Science Initiative (CBSI), a joint effort of the Office of the Executive Vice President and the Kahneman-Treisman Center for Behavioral Science & Public Policy.

"CBSI aspires to foster collaboration between administrative units and academic researchers to use the campus as a research site, tapping behavioral science to develop innovative solutions to campus challenges," said Treby Williams, the University's executive vice president.

Eldar Shafir, the Class of 1987 Professor in Behavioral Science and Public Policy, professor of psychology and public affairs, and inaugural director of the Kahneman-Treisman Center, said the initiative offers researchers the opportunity to gather valuable data, further their scholarly work and contribute to the University in a new way.

"This campus has a group of very talented and hard-working researchers who try to use behavioral insights to produce better outcomes," Shafir said. "We love and care about this campus, and it is so close and available. Why shouldn't we turn our eye partly to what we can do here?"

Behavioral science focuses on scientific experimentation, controlled observation of real-life behavior, and systematic analysis of data to understand the motivations, limitations and biases inherent in human behavior. The Kahneman-Treisman Center brings together faculty members from departments including psychology, sociology, politics, philosophy and the Woodrow Wilson School of Public and International Affairs who pursue research in behavioral science.

Williams said the University can benefit from the application of behavioral-science insights as it tackles challenges from developing programs to reduce the number of cars driven to campus each day or reducing campus energy use to guiding employees toward appropriate health-care programs or helping students make better decisions related to healthy eating, sleep and alcohol consumption.

"Innovative solutions to these kinds of challenges require accurate insights into human behavior and decision-making. Without that knowledge, we won't succeed," Williams said.

Learnings from behavioral science have already been used successfully on campus, such as shifting default participation to "opt-in." For example, in the past, eligible faculty members had to take action to opt in to a benefit that gave them a reduced teaching load following the birth of a child. Shifting the benefit to one that faculty members automatically accrue unless they take action to opt out has increased participation on campus. A similar approach for a retirement savings program has increased the amount employees are saving for retirement.

The CBSI kick-off event included a brainstorming session where administrators and researchers offered ideas and suggested areas for potential collaboration. Khristina Gonzalez, associate dean in the Office of the Dean of the College, and Margaret Frye, assistant professor of sociology, expressed an interest in research about the experience of low-income and first-generation students at Princeton. Gonzalez and Frye have already met with colleagues from the departments of politics and psychology to chart their next steps and will be bringing other administrators and researchers into the project in the fall.

Gonzalez oversees the Freshman Scholars Institute and the Scholars Institute Fellows Program, which are designed to empower undergraduates to thrive at Princeton, particularly those from first-generation and low-income backgrounds. She said CBSI presents an opportunity to learn from research about what helps such students succeed and to contribute to additional research on the topic.

"I think it can be a valuable partnership because there is a lot of great, innovativeresearch in this field and working together will help us think about how to use that research to improve interventions to support our students," Gonzalez said.

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University initiative focuses on behavioral science to tackle campus challenges - Princeton University

Human Behavior – Science NetLinks

Introduction

In this lesson, you will read about some of the important figures and discoveries that have greatly advanced the study of human behavior since the early 1900s. After you have explored the online resources, you will discuss what you have learned with your class.

Begin by reading the introductory page A Science Odyssey: Human Behavior.

The following is a list of key figures of the 20th century whose work impacted on or changed the way we view human behavior or treat mental illness. Use the links provided on the A Science Odyssey: Human Behavior page to learn more about these individuals.

Use the links provided at A Science Odyssey: Human Behavior to learn more about the following landmarks in the history of psychology and medical science.

That's My Theory! is an amusing and informative online "game show" in which you have to guess which of the three disguised psychologists is the real Sigmund Freud (based on questions dealing with the personality, mind function, and the purpose of psychology)

In a brief essay, summarize in your own words what you believe is the key difference between how human behavior was viewed in 1900 and how it is viewed now.

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Human Behavior - Science NetLinks

AgReliant Genetics Restructures Seed Brands – AgWeb

AgReliant Genetics is the third largest corn seed company.

Darrell Smith

TAGS: Marketing, Overseas

December 18, 2014

Starting in 2018, AgReliant Genetics will go from eight representative brands to fourtransitioning half of their brands into LG Seeds. AgReliant says this is part of a growth initiative. AgriGold brand in the U.S. and Pride Seeds in Canada will continue as they are today.

Seed brands going to merge into LG Seeds include: Golden Acres Genetics, Great Lakes Hybrids, Producers Hybrids and Wensman Seed. The company says it will combine the best practices of each brand while maintaining its current employees, facilities and existing relationships.

AgReliant is currently the third largest corn seed company in North Americathe company aims to support its current position while reaching for higher accolades.

The adoption of new technologies, the speed of innovation and farmers growing demand for instant access to information are shifting how we do business, says Mark Herrman, AgReliant Genetics president and CEO in a recent press release. For this reason, we are committed to a strategic long-range plan that will extend our continuous growth and position us to better serve farm businesses and seed dealers in this dynamic environment.

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AgReliant Genetics Restructures Seed Brands - AgWeb