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Fulgent Genetics to Announce Fourth Quarter and Full Year 2016 Financial Results on February 27, 2017 – GlobeNewswire (press release)

February 08, 2017 08:00 ET | Source: Fulgent Genetics, Inc.

TEMPLE CITY, Calif., Feb. 08, 2017 (GLOBE NEWSWIRE) -- Fulgent Genetics, Inc. (Nasdaq:FLGT) (Fulgent Genetics or thecompany) today announced that its fourth quarter and full year 2016 financial results will be released after market close on Monday, February 27, 2017 . The companys Chairman and Chief Executive Officer Ming Hsieh, its Chief Science officer Dr. Harry Gao, and its Chief Financial Officer Paul Kim will host an investment community conference call the same day at 5:00 PM ET (2:00 PM PT) to discuss the results and answer questions.

The call can be accessed through a live audio webcast in the Investor section of the companys website, http://www.fulgentgenetics.com, and through a live conference call by calling 1-855-321-9535, passcode # 65226206. An audio replay will be available in the investors section of the companys website or by calling 1-855-859-2056 through March 6, 2017.

About Fulgent Genetics

Fulgent Genetics is a rapidly growing technology company with an initial focus on offering comprehensive genetic testing to provide physicians with clinically actionable diagnostic information they can use to improve the overall quality of patient care. The company has developed a proprietary technology platform that integrates sophisticated data comparison and suppression algorithms, adaptive learning software, advanced genetic diagnostics tools and integrated laboratory processes. This platform allows the company to offer a broad and flexible test menu while maintaining accessible pricing, high accuracy and competitive turnaround times. The company believes its current test menu, which includes more than 18,000 single-gene tests and more than 275 pre-established, multi-gene, disease-specific panels, offers more genes for testing than its competitors in todays market, which enables it to provide expansive options for test customization and clinically actionable results.

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Fulgent Genetics to Announce Fourth Quarter and Full Year 2016 Financial Results on February 27, 2017 - GlobeNewswire (press release)

Center of Excellence for Poultry Science Hosts Open House for High School, Transfer Students – University of Arkansas Newswire

Photo by Sara Landis

Keith Bramwell, extension reproductive physiologist, assists a student during an embryology workshop at the Open House hosted by the Center of Excellence for Poultry Science.

FAYETTEVILLE, Ark. The Center of Excellence for Poultry Science at the U of Arecently sponsored an Open House for high school juniors, seniorsand college transfer students. Fifty participating students came from Missouri, Texas, Oklahoma, Kansas, Illinois and Arkansas, and included prospective 3-plus-1 program transfer students from the University of Arkansas at Pine Bluff and Arkansas State University.

The 3-plus-1 Certificate of Poultry Science program allows for agriculture majors with an animal science option at UAPB to take poultry science classes at the University of Arkansas as seniors. Those courses are recognized by UAPB's School of Agriculture, Fisheries and Human Sciences, and count toward degree requirements. At the same time, those students earn a Certificate of Poultry Science from the University of Arkansas. Completion of the certificate requires 26-28 hours of poultry science credit.

The Open House provided an opportunity for prospective students to meet poultry science faculty, tour poultry science facilities and learn about the many career opportunities available with a major in poultry science. There were three workshops students participated in: Cell and Molecular Biology, Embryologyand Food Product Technology.

"The Center of Excellence for Poultry Science Open House was a real eye opening experience for our UAPB students," said UAPB interim assistant dean for academic programs and extension livestock specialist David Fernandez. "Having the abilityto physically see the opportunities they would have as part of the UAF/UAPB 3-plus-1 Poultry Science Program generated a lot of excitement and discussion about their future plans."

Students participated in the Open House and afterwardattended the Arkansas-LSU basketball game.

Editor-selected comments will be published below. No abusive material, personal attacks, profanity, spam or material of a similar nature will be considered for publication.

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Center of Excellence for Poultry Science Hosts Open House for High School, Transfer Students - University of Arkansas Newswire

Wilmington volunteer recognized with 4-H state award – Port City Daily

PortCityDaily.com is your source for free news and information in the Wilmington area.

WILMINGTON 4-H volunteers from across North Carolina gathered Feb. 4 to celebrate their accomplishments through the North Carolina 4-H State Awards Recognition program. The awards ceremony was held at the Sheraton Imperial Hotel and Convention Center in Durham, N.C., and was attended by 4-H awards delegates, their families, 4-H staff members and volunteers, industry partners and sponsors.

Related reading:Communities In Schools: Changing lives one student at a time in Brunswick County

Melissa Hight of Wilmington, was recognized for outstanding service and commitment to the 4-H school enrichment program, Embryology in the Classroom. Melissa has made tremendous improvements to the program that brings fertilized chicken eggs to 2nd graders across New Hanover County. She also obtained funding from New Hanover County Farm Bureau to sponsor this program.

Melissa has brought embryology to several new schools, extending our reach to over 100 additional students this year. She also shares a lesson from the 4-H Embryology curriculum with students, going above and beyond by bringing props and energy with her. She leaves each classroom with a book about chickens and Im an EGG-cellent Kid! stickers.

These changes have taken a good program and made it great. Not only are students learning important facts about the life cycle of a chicken, they are also learning what 4-H is about and that it can be fun.

Leslie Dill serves as New Hanover Countys 4-H Agent. She received a B.A. in animal science from The Ohio State University and an M.A. in agriculture and extension education from N.C. State University. She can be reached at 910-798-7660 or leslie_dill@ncsu.edu.

4-H, the largest youth development organization in the world, is a community of seven million young people across the globe learning leadership, citizenship, and life skills. To learn more about New Hanover County 4-H, visit newhanover.ces.ncsu.edu.

-Content provided by Leslie Dill, 4-H Youth Development

This content was provided by a community member via Local Shout, a new initiative at Port City Daily. Port City Daily cannot guarantee the accuracy of information presented in this story. If you have additional information or would like to submit a story, please contact shout@portcitydaily.com.

4-H, 4H, Local Shout, Melissa Hight

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Wilmington volunteer recognized with 4-H state award - Port City Daily

Ransomware 2.0: Anatomy of an emerging multibillion business – CSO Online

Technically speaking, almost all components of ransomware, such as spear phishing, watering hole attacks involving popular and trustworthy websites, antivirus evasion techniques or data encryption algorithms, are well-known and have been used separately by hackers since years. However, modern ransomware certainly merits a classification as one of the most evolving sectors of cybercrime in 2017.

Though it is quite difficult to calculate the overall damage caused by ransomware in 2016, some researchers state that cybercriminals received over $1 billion in ransom payments last year. Others mention a 3,500% increase in the criminal use of infrastructure that helps run ransomware campaigns. Carbon Black says that ransomware is the fastest growing malware across industries, up 50% in 2016. Technology (218%), utilities and energy (112%) and banking (93%) saw the highest year-on-year ransomware growth last year.

Due to an important lack of qualified technical personnel and other resources, law enforcement agencies are globally unprepared to detect, prevent and prosecute this type of digital crime. Moreover, more and more cases of ransom payment by the police have become public, while those police officers who dare to resist take a substantive risk. There is the Texas police who lost eight years of their investigative work and all of the evidence by refusing to pay cybercriminals. This sad statistic explains why the majority of despaired victims of cybercrime fail to report it to the law enforcement agencies.

Attackers can easily rent a Ransomware-as-a-Service (RaaS) infrastructure for as low as $39.99 per month, making up to $195,000 of monthly profit without much effort in comparison to other niches of digital fraud and crime. The business of ransomware has become so attractive that some cybercriminals dont even bother to actually encrypt the data, but just extort money from their victims with fake malware. The victims are so scared by media stories about ransomware, combined with law enforcement agencies inability to protect them or at least to punish the offenders, that they usually pay.

The new generation of ransomware attacks IoT and smart devices, locking not only mobiles and smart TVs, but also doors in hotels and air conditioning systems in luxury smart houses. Criminals switch from file encryption to database encryption and web applications, demonstrating a great scalability of ransomware tactics.

To increase their profits, hacking teams behind the ransomware campaigns now threaten to send the victims sensitive data to all of their contacts instead of just deleting it. Cryptocurrencies allow attackers to receive online payments almost without any risk of being traced and prosecuted. Despite the media hype around blockchains ability to reinvent and improve the world, so far only the cybercriminals have entirely leveraged the full potential of this emerging technology.

A simple business model, high profits, accessibility and affordability of resources to deploy large-scale attacking campaigns, and low risks in comparison to other sectors of (cyber)crime, assure the flourishing future of ransomware. All of this without mentioning the problem of global inequality actually causing the cybercrime, which I briefly described in Forbes recently.

Nonetheless, it does not mean that organizations should give up. The FBI confirms the skyrocketing problem of ransomware, but suggests relying on prevention rather than paying ransom to the criminals. PwC also suggests to plan and prepare the organization to this kind of incident in order to have internal capabilities to recover without suffering important financial losses.

Some cybersecurity vendors, like SentinelOne, contractually guarantee protection and provide a financial insurance for their clients. Others, like Kaspersky, offer free tools to decrypt data compromised by popular malware. Last, but not least, Europols No More Ransom public-private partnership with other law enforcement agencies and leading cybersecurity companies, provides a comprehensive collection of free tools to recover the data and clean the systems infected with ransomware.

Below are six essential steps that will help you avoid paying ransoms:

By following those rules, any company and organization can significantly reduce their risk of having to pay ransom. Attackers would rather target easy and unprepared victims, instead of spending their efforts on any particular organization. Properly implemented security standards, like ISO 27001, can also prevent the vast majority of costly ransomware incidents.

However, keep in mind that information security starts with factual security, not with a paper-based compliance. If your IT infrastructure is secure in practice, you will not only easily pass the majority of compliance and regulation requirements, but you will also defend your business from many vectors of cybercrime, including the growing monster of ransomware.

This article is published as part of the IDG Contributor Network. Want to Join?

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Ransomware 2.0: Anatomy of an emerging multibillion business - CSO Online

The Woman Behind a Secret Grey’s Anatomy Experiment – WNYC

In 2006, editors from Newsweek magazine picked this picture for the front of an issue on the 25th anniversary of AIDS. The woman, Jennifer Jako, was HIV positive and 6 months pregnant. (Ethan Hill ) Feb 8, 2017 by Kenny Malone

About nine years ago, 17.5 million people tuned into an episode of Greys Anatomy that, on the surface, appeared like any other high-stakes surgery, high-drama love triangles. What those millions of Greys viewers didnt know was that they were guinea pigs for a massive, secret experiment.

That experiment was arguably a referendum about a single woman: Jennifer Jako, and her decision to become a mother.

In 1991, at the age of 18, Jako had a one night stand with a high-school friend. It was the only time shed ever had sex without a condom. She contracted HIV and spent years trying to debunk misconceptions: producing a documentary that aired on MTV, speaking at college campuses and on talk shows.

Over time, the countrys view of HIV evolved. As people started living longer, stigma decreased. People generally understood that the infection wasnt a death sentence any longer.

But there was one area people couldnt seem to understand: Pregnancy. Studies showed the general public simply didnt know or didnt believe that an HIV-positive woman, with the right treatment, had a tremendously low chance of passing the virusonto her baby less than 2-percent at the time.

Jennifer Jako got a cruel lesson in where the public stood when she appeared on the cover of Newsweek magazine, six months pregnant.

Later, as an experiment, the Kaiser Family Foundation decided to see if they could move the needle by trying something totally different: product placement of medical information in a Greys Anatomy episode.

In this episode of Only Human we tell the epic story of Jennifer Jako and how she managed to sneak into our livings rooms and, possibly, change public opinion forever.

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Only Human is a show about health that we all can relate to. Because every body has a story. Produced by WNYC Studios.

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The Woman Behind a Secret Grey's Anatomy Experiment - WNYC

The Anatomy of Washington Husky Quarterback Jake Browning … – FOXSports.com

Washington Husky Quarterback Jake Browning is recovering from surgery on his throwing shoulder. Heres why this is very good news

Quarterback Jake Browning led the Washington Huskies to the NCAA football playoffs. There, he ran into a tough Alabama defense and the team lost the game 24-7. But unknown to many, Browning was not up to 100%. In fact, he had injured his throwing shoulder early in the season in the home victory over Arizona State.

The following week, the Huskies would lose to the visiting USC Trojans 26-13. They would not lose another game until the playoffs.

In retrospect, his performance in the Arizona State and USC games were below average for the young hurler. With a season average rating of 167.5, his Arizona State win came in at 61.4 percent completion for 338 yards, two touchdowns and two interceptions for a rating of 131.8. The following week, he completed 37.5percent of his passes for 118yards twotouchdowns and zerointerceptions for a rating of 106.3. In the playoff game facing Alabama, he completed 52.6 percent of his passes for 150 yards, one touchdown and two interceptions for a rating of 83.9. All efforts contributed to the two season losses.

But an injury to the throwing shoulder can lead to below average performances. While we do not know the exact nature of the injury, we do know these facts:

So in summary, the injury is relatively minor. But based on the evidence, what is the most likely injury?

Nov 12, 2016; Seattle, WA, USA; Washington Huskies quarterback Jake Browning (3) lies on the turf following a 21-yard loss on a scramble against the USC Trojans during the fourth quarter at Husky Stadium. USC defeated Washington, 26-13. Mandatory Credit: Joe Nicholson-USA TODAY Sports

In summary, there are three types of soft tissues that could be mended with a minor surgical procedure: cartilage, ligaments, and tendons.

While cartilage is the plastic-like tissue that covers the ends of bones, acting like lubricant and shock absorbers, ligaments are the soft connective tissue that holds the joint together. Secondly, tendons are the soft connective tissues that anchor muscles to bones and joints. In the case of a minor shoulder injury, any of the three tissues could be injured.

Healing any of these types of injuries are similar in arthroscopic surgery. So lets discuss the process:

Phase I : Post Operative recovery This is the period of time immediately following surgery. Browningwill need to keep the shoulder as immobile as possible and to keep hisarm in a sling. The use of the sling keeps the weight of hisarm off of thesoft tissues which assists in the healing process. (through Feb 2017)

Phase II: Passive Physical Therapy For the next six to eight weeks, Browning enters passive physical therapy. Now he will work with a physical therapist to perform gentle, assisted exercises to help regain movement and range of motion inhis shoulder. Because damaged tissues are still actively healing,his shoulder joint needs to be supported during movement. (Mid April 2017)

Phase III: Active Physical Therapy Now the therapy changes from motion to strength. Browning will be tasked with building his shoulder strength gradually to avoid reinjury, but at an intensive pace to meet the demands of the 2017 football season. While this period will progress quickly, the minimum is likely to be three months time. (End July 2017)

Oct 8, 2016; Eugene, OR, USA; The University of Washington Huskies football team takes the field before the start of a game against the University of Oregon at Autzen Stadium. The Huskies won 70-21. Mandatory Credit: Troy Wayrynen-USA TODAY Sports

The Washington Husky Spring Football game will be held on Saturday, April 22nd. Its highly unlikely Jake Browning will be playing in that game. The team will likely have Tony Rodriguez, Jeff Lindquist, Blake Gregory, Daniel Bridge-Gadd and K.J. Carta-Samuels active for the game. The team also has 2017 recruit QB Jake Haener in the mix for the 2017 season.

It is very unlikely that Jake Browning will suit up for this game.

The Huskies regular season begins on September 1st on a coast to coast road trip to Piscataway, New Jersey to face the Rutgers Scarlet Knights. As of now, Browning will very likely be suited up and ready to go for the season opener.

With his shoulder fully healed, Browning should be far more effective to close out this season. It was the Seattle Times Adam Jude who first reported the shoulder injury to quarterback Jake Browning in mid January. He followed up with a second article on February 1 to confirm that Brownings status was determined to be doing well by head coach Chris Petersen.

Weve already had a plan you know, Jake is one of those guys that just loves to throw and throw and throw, Petersen said. So from really when he got here, weve been trying to back him off (after) these long years, to make sure. And so he should be fine for spring ball, but also want to give these other (quarterbacks) some really good work in spring ball. Chris Petersen per Adam Judes interview

And so, there was a little ambiguity here. Yes, Jake Browning is right on track. Yes, He will be fine for spring ball. He may even be throwing by then. But dont panic when he isnt suiting up for the annual Spring Football game.

He will be good, but he wont be THAT good.

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The Anatomy of Washington Husky Quarterback Jake Browning ... - FOXSports.com

Scientists Discover 83 Genetic Mutations That Help Determine Your Height – Huffington Post

Ever wonder how much of your height you inherited from your parents?

A large-scale genetic study published recently in the journal Natureis helping shed some light on the factors that determine whether a person grows to be 6-feet-1 or 5-feet-2.

While scientists already had a good idea of the most common genetic factors that contribute to height, the new findings uncover a number of rare genetic alterations that can play a surprisingly major role in human growth.

Using data from the Genetic Investigation of Anthropometric Traits consortium (a group also known as GIANT), scientists from the Broad Instituteat MIT and Harvard analyzed genetic information from more than 700,000 people, discovering 83 DNA changes that play a part in determining a persons height.

In their previous work, the same research team identified nearly 700 common genetic factors linked with height. Now, theyve identified a number of rare genetic variants for human growth that have an even larger effect than most common factors. For some people, these rare DNA changes may account for height differences of up to a full inch.

Overall, common variants still contribute more to height than rare variants, Dr. Joel Hirschhorn, the studys lead author and a professor of pediatrics and genetics at Boston Childrens Hospital and Harvard Medical School, told The Huffington Post. But, for the person who happens to carry one of the rare variants, the impact can be much greater than for common variants. For the variants we looked at, this was up to almost an inch... as opposed to a millimeter or less for the common variants.

Using a new technology called the ExomeChip, the researchers were able to scan the genomes of large populations to find rare markers that correlated with a particular height. They identified 51 uncommon variants found in less than 5 percent of people, and 32 rare variants found in less than 0.5 percent of the population.

With the addition of these uncommon variants, geneticists can now account for 27 percent of the genetics determining height up from 20 percent based on earlier studies.

Heritability is by far the largest factor contributing to individual height.

Today, in places where most people get enough nutrition in childhood to grow to their potential, about 80 percent or more of the variability in height is due to genetic factors that we inherit from our parents, Hirschhorn explained.

According to the studys authors, this method of testing rare genetic variants could be used to investigate uncommon DNA changes involved in other aspects of human health.

Looking at rare variants in genes was helpful in understanding the biology of human growth, Hirschhorn said. With a big enough study, similar approaches could be valuable in understanding the biology of many diseases, which could help guide better treatments.

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Scientists Discover 83 Genetic Mutations That Help Determine Your Height - Huffington Post

Abortion is really settled science — Robert Rittmann – Madison.com

After 44 years and more than 58 million aborted babies, I don't know how anyone can continue to ignore the March For Life.

I don't know how anyone can ignore the science of an ultrasound picture and deny that it is a baby in the womb. Children are not like bad teeth one yanks out because they produce pain or are inconvenient.

In this day and age, if you are educated in basic science, you must reject abortion on the basis that all individual citizens are equal, and the freedom of choice is for choices that do not hurt or exterminate other human individuals.

Science shows the baby has separate DNA that is different from the mother's. The new human has a genetic composition that is absolutely unique, different from any other human that has ever existed, including that of his or her mother. You can find this information in any basic textbook of embryology.

Scientist don't argue against this.

Unlike climate change, this really is settled science. We all have an unalienable right to life, liberty and the pursuit of happiness.

Robert Rittmann, Sun Prairie

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Abortion is really settled science -- Robert Rittmann - Madison.com

Biochemistry professor continues to follow passions at 100 years old – The Maneater

Eighty years ago, professor emeritus of biochemistry Boyd ODell began taking classes at MU. Now 100 years old, ODell, who has made many discoveries and inspired generations of colleagues, can still be found in his office in Eckles Hall.

I have some questions I really would like to answer, and Id rather think about answering those questions than retiring, ODell said.

ODell technically retired in 1988, but still does part-time research on campus.

In September, a celebration honoring the 40th anniversary of the biochemistry department served as an early 100th birthday party for ODell. In December, a plaque was unveiled, naming the bridge connecting Schweitzer Hall to the Schlundt Annex the Boyd ODell Bridge of Discovery.

I hope the bridge will be a bridge to the future for all the students and progress will be made in research and learning, ODell said at the unveiling.

Over the years, ODell has served as a mentor and a friend for many of his colleagues and students. Biochemistry professor Judy Wall first met ODell when she joined the MU faculty in 1978.

Hes an incredible gentleman, very professional, a great scholar and a truly kind person, Wall said.

Wall remembers when she and ODell were assigned to evaluate a graduate students grant proposal for a comprehensive exam. This was Walls first time evaluating this type of exam, and the only other female faculty member in the department did not attend their presentations.

I was the sole female faculty member and, you know, a silly person who was in the process of thinking about impressing all of my peers and making sure they didnt think I was an idiot at the evaluations, Wall said. So I was all set for getting this guy because I didnt think his proposal was great.

ODell went first. He discussed the importance of the problem the student had addressed and the strengths of the work before introducing criticism.

That was a wonderful experience for me because I thought thats exactly the way you should do it, Wall said. You have to earn the right to criticize by showing that you understand whats going on and you have to earn the right to begin to make constructive suggestions. Dr. ODell had shown me that was the professional way of going about it.

Wall uses this same approach anytime she has to evaluate anything in a similar manner.

He didnt realize, and I dont think I realized at the time, that he was mentoring me, but he certainly was, Wall said.

ODell decided to pursue education because he admired his teachers, who were his first role models.

I always had an ambition to be a teacher, ODell said. What did a farm boy in Carroll County have as role models? There was two things that I can think of, teacher was the most obvious one, and veterinarian.

ODell was born on a farm outside of Hale, Missouri, on Oct. 14, 1916. Becoming a veterinarian wasnt an option he considered, because it wasnt a financial possibility.

My parents were just poor farmers, and they couldnt help me, he said. I had to pave my way.

The summer after he graduated high school, ODell took an examination to become a teacher.

I passed all subjects with high scores except one, and that was pedagogy, ODell said. I didnt even know what pedagogy was. I suppose its the art of teaching.

That summer, ODell took classes at the University of Central Missouri, which was known as Warrensburg Teachers College at the time. He then began working in a one-room schoolhouse, where he taught first through eighth grade.

It was kind of fun in retrospect, ODell said. And that was in the depths of the Depression, to be paid $50 a month was a very good job. A lot of people were unable to even find a job.

Because he wanted to continue his education, ODell left the grade school after four years.

After a few years I transferred to the university here and got jobs one way or another and was able to support myself, he said.

He wanted to study bacteriology, but MU didnt have a program, so ODell was advised to become a chemistry major.

I worked for Dr. A.G. Hogan, who was my mentor for my Ph.D. At that time, he was interested in a vitamin that now is known as folic acid, ODell said.

ODell went on to work for a pharmaceutical company in Detroit after receiving his degree. With the end of World War II, MU saw an increase in students and invited ODell back to become a professor.

Coming back to Mizzou was kind of an easy choice because that was home. Im a Missourian through and through, ODell said.

ODell then studied the existence of unknown vitamins as an assistant professor.

At that time, an assistant professor was really an assistant to the professor, ODell said. When I became a little further along and had the independence, I still followed the question of, are there still unknown vitamins?

ODell went on to study the role of copper and zinc in the body. Among his discoveries was the revelation that copper deficiencies in animals can cause death through the rupture of the aorta, in the heart.

The opportunity arose for me to go on a sabbatical to Australia, ODell said. And why would I want to go to Australia? If youre interested in copper, its the place to go because much of the soil in Australia is copper-deficient.

In Australia, ODell saw that copper deficiency in sheep can cause symptoms similar to Parkinsons disease. He later observed the same results in rats.

We became interested in zinc deficiency around the same time, ODell said. We found that zinc deficiency in animals stops growth and causes increased subject to disease. Diarrhea is a common complaint of zinc-deficient animals and children.

He then discovered that phytic acid, which appears in plants such as soybeans and corn, can actually impact the way the body absorbs zinc.

Scientists want to know why does zinc deficiency cause these signs and symptoms in humans and animals, ODell said. Ive been interested in trying to solve that question for quite a number of years.

ODell is currently researching the importance of zinc in maintaining calcium channels.

If you think back of all the factors that a cell does, a cell divides, a cell secretes, contracts and carries messages, ODell said. All of this is dependent on a calcium channel, and if you take away zinc, the channel fails and you get all these symptoms. I think that that is the true, fundamental function of zinc to maintain the calcium channel.

ODell and Wall, a professor of biochemistry, have since worked together on a variety of committees and both taught biochemistry to first-year medical students.

He was always incredibly prepared, just beautiful lectures and so absolutely timely, Wall said. He knew the literature and was just great.

Another of ODells colleagues, professor emerita of biochemistry Grace Sun, also spoke of ODells role as a mentor.

Right now, Ive been retired for two years only and hes been retired for many more years, Sun said. I would say that hes a role model for me, and I wish I could do half as much like him.

The two became friends in the 80s, when a colleague Sun had met while working as a visiting professor in Taiwan came to MU to study with ODell.

ODell and his wife used to throw parties around the holidays where they would serve American foods, Sun said.

We loved it because we have a lot of international students and he has always a group of them, Sun said. At the time, he was like a hub for the international students.

Sun says ODell still interacts with colleagues and former research assistants by attending seminars and events on campus.

I remember one time, this must have been four or five years ago, and hes way over 90 and he wrote me an email, Sun said. He read a paper and then he said, Hey, Grace, maybe we can work together to do something on this area. I was so shocked. I was really amazed how he must be reading a lot of papers at home or in his office.

Now, ODell does experiments once or twice a week with cells that are grown in the Life Science Building.

I asked to use the equipment and I think they decided they better volunteer to do some of the work rather than trust me, ODell said with a laugh.

An undergraduate was assigned to help ODell grow and transfer the cells, Wall said.

It came holiday time, and the undergraduate was coming up on holiday, and so instead of imposing on this woman, Boyd decided he would just teach himself how to culture the human tissue culture, and so he did it, Wall said. Every day he would come over and transfer his cells and work with his cells. He walks over form Eckles to the Life Sciences Center and back again and has learned how to do this. What a terrifically fearless person he is when it comes to science.

ODell doesnt just walk across campus; he also walks from his house every time he comes to do research.

Most of my career I rode a bicycle to work, ODell said. I dont have a car, and I dont ride my bicycle anymore that leaves walking. I like walking. I think its good exercise, and I need exercise.

ODells daughter Ann, who lives in Columbia, helps drive him when he needs to go shopping and eats with him every week. ODell has a son, David, who lives in California, as well as four grandchildren and two great-grandchildren.

Outside of science, ODells hobbies include photography and bird-watching.

I was always interested in bird-watching and nature work; I guess that might fall from the science, ODell said. Even when I was teaching at the grade school, I had projects for the kids where wed collect plants.

After 100 years, ODell recognizes the importance of lifelong learning and following ones interests.

I think you should, in general even beyond science, you should pick a job or do what you have a real passion for, ODell said. I think if you really are keenly interested in it you will be successful.

Edited by Kyle LaHucik | klahucik@themaneater.com

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Biochemistry professor continues to follow passions at 100 years old - The Maneater

Sumo protein explored as likely source for some congenital heart defects – Medical Xpress

February 7, 2017 by Brandi Klingerman Professor Paul Huber. Credit: University of Notre Dame

Small ubiquitin-like modifier (SUMO) proteins are small peptides that get added on to other proteins to regulate their activity. While SUMO has many regulatory roles in cells, it is especially important for controlling gene expression during early development. Just a few years ago this connection between SUMO and gene regulation was relatively unknown, but now, Notre Dame researchers are exploring how a disruption to the SUMO protein's ability to regulate embryo development may be linked to congenital heart defects.

Paul Huber, professor of chemistry and biochemistry, and Norman Dovichi, the Grace-Rupley Professor of Chemistry and Biochemistry, are working together to understand the role of all proteins in embryo development using Xenopus laevis or the African claw frog. This species is known for having a similar gene structure to that of the human genome, meaning that findings related to this species have the potential to provide a deep understanding about human diseases.

When discussing their research, Dovichi said, "In 2014, Huber and I completed a study using Xenopus laevis embryos to understand how more than 4,000 proteins fluctuate during the different stages of development. We found that certain proteins spike or lower during specific stages. For example, a number of proteins that are used during the creation of cardiovascular tissue rose during stage 13, when organs develop."

In these early experiments, Huber found that when SUMO activity was repressed, many of the embryos had two predominate phenotypes, one of which was heart defects. Then, new studies began linking mutations in SUMO protein to heart failure as well as congenital heart defects. This is when the Notre Dame researchers began to develop the next steps for their research.

"At the time, there was not a lot of information about the role of the SUMO protein, but our theory was that it was critical for proper development of the heart," said Huber. "To study the protein's specific impact, we inhibited SUMO activity in the developing cardiovascular tissue. This will allow us to compare the proteome or all of the proteins that are expressed by a cell of the defective hearts with their normal counterparts."

To support the research, Olivia Cox, a Notre Dame graduate student, collaborated with Daniel Weeks, professor of biochemistry and pediatrics at the University of Iowa, and identified three predominate heart defects in the SUMO-deficient hearts: septal defects commonly thought of as holes in the heart abnormal turning of the outflow tract, and noncompaction cardiomyopathy.

The goal of this research is to use the proteome comparisons to specifically identify which proteins are responsible for congenital heart defects. Additionally, Huber, affiliated with the Harper Cancer Research Institute (HCRI) and the Center for Stem Cells and Regenerative Medicine, and Dovichi, affiliated with Advanced Diagnostics and Therapeutics as well as the HCRI, plan to continue exploring the SUMO protein's significance in other areas of embryo development. This research could help explain why other development defects arise, and eventually lead to a solution for increasing SUMO protein expression when a mutation occurs.

Explore further: SUMO-snipping protein plays crucial role in T and B cell development

More information: Liangliang Sun et al. Quantitative proteomics of Xenopus laevis embryos: expression kinetics of nearly 4000 proteins during early development, Scientific Reports (2014). DOI: 10.1038/srep04365

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Sumo protein explored as likely source for some congenital heart defects - Medical Xpress