Sung, H. et al. Global cancer statistics 2020: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries. CA Cancer J. Clin. 71, 209249 (2021).
Article PubMed Google Scholar
Pfaendler, K. S. & Tewari, K. S. Changing paradigms in the systemic treatment of advanced cervical cancer. Am. J. Obstet. Gynecol. 214, 2230 (2016).
Article PubMed Google Scholar
Hegde, P. S. & Chen, D. S. Top 10 challenges in cancer immunotherapy. Immunity 52, 1735 (2020).
Article CAS PubMed Google Scholar
Frenel, J.-S. et al. Safety and efficacy of pembrolizumab in advanced, programmed death ligand 1-positive cervical cancer: results from the phase Ib KEYNOTE-028 trial. J. Clin. Oncol. 35, 40354041 (2017).
Article CAS PubMed Google Scholar
Hornburg, M. et al. Single-cell dissection of cellular components and interactions shaping the tumor immune phenotypes in ovarian cancer. Cancer Cell 39, 928944 (2021).
Article CAS PubMed Google Scholar
Yuan, S., Norgard, R. J. & Stanger, B. Z. Cellular plasticity in cancer. Cancer Discov. 9, 837851 (2019).
Article CAS PubMed PubMed Central Google Scholar
Barkley, D. et al. Cancer cell states recur across tumor types and form specific interactions with the tumor microenvironment. Nat. Genet. 54, 11921201 (2022).
Article CAS PubMed PubMed Central Google Scholar
The Cancer Genome Atlas Research Network. Integrated genomic and molecular characterization of cervical cancer. Nature 543, 378384 (2017).
Gavish, A. et al. Hallmarks of transcriptional intratumour heterogeneity across a thousand tumours. Nature 618, 598606 (2023).
Article CAS PubMed Google Scholar
Puram, S. V. et al. Single-cell transcriptomic analysis of primary and metastatic tumor ecosystems in head and neck cancer. Cell 171, 16111624 (2017).
Article CAS PubMed PubMed Central Google Scholar
Bedard, M. C. et al. Single cell transcriptomic analysis of HPV16-infected epithelium identifies a keratinocyte subpopulation implicated in cancer. Nat. Commun. 14, 1975 (2023).
Article CAS PubMed PubMed Central Google Scholar
Puram, S. V. et al. Cellular states are coupled to genomic and viral heterogeneity in HPV-related oropharyngeal carcinoma. Nat. Genet. 55, 640650 (2023).
Article CAS PubMed Google Scholar
Kinker, G. S. et al. Pan-cancer single-cell RNA-seq identifies recurring programs of cellular heterogeneity. Nat. Genet. 52, 12081218 (2020).
Article CAS PubMed PubMed Central Google Scholar
Gruosso, T. et al. Spatially distinct tumor immune microenvironments stratify triple-negative breast cancers. J. Clin. Invest. 129, 17851800 (2019).
Article PubMed PubMed Central Google Scholar
Chen, A. et al. Spatiotemporal transcriptomic atlas of mouse organogenesis using DNA nanoball-patterned arrays. Cell 185, 17771792 (2022).
Article CAS PubMed Google Scholar
Vahid, M. R. et al. High-resolution alignment of single-cell and spatial transcriptomes with CytoSPACE. Nat. Biotechnol. (2023). https://doi.org/10.1038/s41587-023-01697-9
Wang, H. et al. Tumor immunological phenotype signature-based high-throughput screening for the discovery of combination immunotherapy compounds. Sci. Adv. 7, eabd7851 (2021).
Article CAS PubMed Google Scholar
Cristescu, R. et al. Pan-tumor genomic biomarkers for PD-1 checkpoint blockade-based immunotherapy. Science 362, eaar3593 (2018).
Article PubMed PubMed Central Google Scholar
Schubert, M. et al. Perturbation-response genes reveal signaling footprints in cancer gene expression. Nat. Commun. 9, 20 (2018).
Article PubMed PubMed Central Google Scholar
Derynck, R., Turley, S. J. & Akhurst, R. J. TGF biology in cancer progression and immunotherapy. Nat. Rev. Clin. Oncol. 18, 934 (2021).
Article PubMed Google Scholar
Song, J. et al. The role of FABP5 in radiation-induced human skin fibrosis. Radiat. Res. 189, 177186 (2017).
Article PubMed Google Scholar
Krishnamurty, A. T. et al. LRRC15+ myofibroblasts dictate the stromal setpoint to suppress tumour immunity. Nature 611, 148154 (2022).
Article CAS PubMed PubMed Central Google Scholar
Dominguez, C. X. et al. Single-cell RNA sequencing reveals stromal evolution into LRRC15+ myofibroblasts as a determinant of patient response to cancer immunotherapy. Cancer Discov. 10, 232253 (2020).
Zhu, K., Cai, L., Cui, C., de los Toyos, J. R. & Anastassiou, D. Single-cell analysis reveals the pan-cancer invasiveness-associated transition of adipose-derived stromal cells into COL11A1-expressing cancer-associated fibroblasts. PLoS Comput. Biol. 17, e1009228 (2021).
Article CAS PubMed PubMed Central Google Scholar
Chu, T., Wang, Z., Peer, D. & Danko, C. G. Cell type and gene expression deconvolution with BayesPrism enables Bayesian integrative analysis across bulk and single-cell RNA sequencing in oncology. Nat. Cancer 3, 505517 (2022).
Article CAS PubMed PubMed Central Google Scholar
Fan, J. et al. Multi-omics characterization of silent and productive HPV integration in cervical cancer. Cell Genom. 3, 100211 (2023).
Article CAS PubMed PubMed Central Google Scholar
Sengupta, S. et al. Mesenchymal and adrenergic cell lineage states in neuroblastoma possess distinct immunogenic phenotypes. Nat. Cancer 3, 12281246 (2022).
Article CAS PubMed PubMed Central Google Scholar
Spranger, S. et al. Up-regulation of PD-L1, IDO, and Tregs in the melanoma tumor microenvironment is driven by CD8+ T cells. Sci. Transl. Med. 5, 200ra116 (2013).
Article PubMed PubMed Central Google Scholar
Chen, J. et al. Neoadjuvant camrelizumab plus chemotherapy for locally advanced cervical cancer (NACI Study): a study protocol of a prospective, single-arm, phase II trial. BMJ Open 13, e067767 (2023).
Article PubMed PubMed Central Google Scholar
Rittmeyer, A. et al. Atezolizumab versus docetaxel in patients with previously treated non-small-cell lung cancer (OAK): a phase 3, open-label, multicentre randomised controlled trial. Lancet 389, 255265 (2017).
Article PubMed Google Scholar
Fehrenbacher, L. et al. Atezolizumab versus docetaxel for patients with previously treated non-small-cell lung cancer (POPLAR): a multicentre, open-label, phase 2 randomised controlled trial. Lancet 387, 18371846 (2016).
Article CAS PubMed Google Scholar
Patil, N. S. et al. Intratumoral plasma cells predict outcomes to PD-L1 blockade in non-small cell lung cancer. Cancer Cell 40, 289300 (2022).
Zha, H. et al. S100A9 promotes the proliferation and migration of cervical cancer cells by inducing epithelialmesenchymal transition and activating the Wnt/catenin pathway. Int. J. Oncol. 55, 3544 (2019).
CAS PubMed PubMed Central Google Scholar
Wang, S. et al. SERPINB3 (SCCA1) inhibits cathepsin L and lysoptosis, protecting cervical cancer cells from chemoradiation. Commun. Biol. 5, 46 (2022).
Article CAS PubMed PubMed Central Google Scholar
Seo, J. et al. Fatty-acid-induced FABP5/HIF-1 reprograms lipid metabolism and enhances the proliferation of liver cancer cells. Commun. Biol. 3, 638 (2020).
Article CAS PubMed PubMed Central Google Scholar
Yan, S. et al. SAR studies on truxillic acid mono esters as a new class of antinociceptive agents targeting fatty acid binding proteins. Eur. J. Med. Chem. 154, 233252 (2018).
Article CAS PubMed PubMed Central Google Scholar
Vitale, I., Shema, E., Loi, S. & Galluzzi, L. Intratumoral heterogeneity in cancer progression and response to immunotherapy. Nat. Med. 27, 212224 (2021).
Article CAS PubMed Google Scholar
Lin, F. et al. Stanniocalcin 1 promotes metastasis, lipid metabolism and cisplatin chemoresistance via the FOXC2/ITGB6 signaling axis in ovarian cancer. J. Exp. Clin. Cancer Res. 41, 129 (2022).
Article CAS PubMed PubMed Central Google Scholar
Chen, K. et al. Single cell RNA-seq reveals the CCL5/SDC1 receptorligand interaction between T cells and tumor cells in pancreatic cancer. Cancer Lett. 545, 215834 (2022).
Article CAS PubMed Google Scholar
Yang, H. et al. Therapeutic potential of targeting membrane-spanning proteoglycan SDC4 in hepatocellular carcinoma. Cell Death Dis. 12, 492 (2021).
Article CAS PubMed PubMed Central Google Scholar
Kurozumi, A. et al. Tumorsuppressive microRNA223 inhibits cancer cell migration and invasion by targeting ITGA3/ITGB1 signaling in prostate cancer. Cancer Sci. 107, 8494 (2016).
Morgan, M. R., Humphries, M. J. & Bass, M. D. Synergistic control of cell adhesion by integrins and syndecans. Nat. Rev. Mol. Cell Biol. 8, 957969 (2007).
Article CAS PubMed PubMed Central Google Scholar
Wang, W. et al. Identification of biomarkers for lymph node metastasis in early-stage cervical cancer by tissue-based proteomics. Br. J. Cancer 110, 17481758 (2014).
Article CAS PubMed PubMed Central Google Scholar
Liu, F. et al. Identification of FABP5 as an immunometabolic marker in human hepatocellular carcinoma. J. Immunother. Cancer 8, e000501 (2020).
Article PubMed PubMed Central Google Scholar
OSullivan, S. E. & Kaczocha, M. FABP5 as a novel molecular target in prostate cancer. Drug Discov. Today 25, 20562061 (2020).
Article Google Scholar
Adamson, J. et al. High-level expression of cutaneous fatty acid-binding protein in prostatic carcinomas and its effect on tumorigenicity. Oncogene 22, 27392749 (2003).
Article CAS PubMed Google Scholar
Al-Jameel, W. et al. Inactivated FABP5 suppresses malignant progression of prostate cancer cells by inhibiting the activation of nuclear fatty acid receptor PPAR. Genes Cancer 10, 8096 (2019).
Article CAS PubMed PubMed Central Google Scholar
Farrell, M. et al. Fatty acid binding proteins as a novel therapeutic target in multiple myeloma. Blood 138, 1569 (2021).
Article Google Scholar
Levi, L. et al. Genetic ablation of the fatty acidbinding protein FABP5 suppresses HER2-induced mammary tumorigenesis. Cancer Res. 73, 47704780 (2013).
Article CAS PubMed PubMed Central Google Scholar
Tokunaga, R. et al. CXCL9, CXCL10, CXCL11/CXCR3 axis for immune activation a target for novel cancer therapy. Cancer Treat. Rev. 63, 4047 (2018).
Article CAS PubMed Google Scholar
Shahbandi, A. et al. Breast cancer cells survive chemotherapy by activating targetable immune-modulatory programs characterized by PD-L1 or CD80. Nat. Cancer 3, 15131533 (2022).
Article CAS PubMed PubMed Central Google Scholar
Li, H. & Durbin, R. Fast and accurate short read alignment with Burrows-Wheeler transform. Bioinformatics 25, 17541760 (2009).
Article CAS PubMed PubMed Central Google Scholar
McKenna, A. et al. The Genome Analysis Toolkit: a MapReduce framework for analyzing next-generation DNA sequencing data. Genome Res. 20, 12971303 (2010).
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