Grey's Anatomyhas seen a lot of characters come and go from the hospital, but the biggest character growth fans have seen develop is through Alex Karev (Justin Chambers). Currently one of the remaining original characters, Alex has quickly become a fan favorite with his attentive skills in pediatrics and his compassionate nature with friends.

RELATED: Grey's Anatomy: 20 Things Wrong With Alex Karev We All Choose To Ignore

However, the surgeon has had to overcome the largest of obstacles as he allows his violent temper and personal grudges to cloud his judgment. From his humiliation of Izzie (Katherine Heigl) to Alex's treatment of George (T.R. Knight), here are the 10 worst things he has done, ranked.

Although Alex revealed her infidelity to wind George up, Callie (Sara Ramirez) didn't deserve for the peds physician to get involved in her life. The grudge also led to Alex and George endangering bartender Joe's (Steven W. Bailey) partner when they got into a fight.

This fight was pointless considering the incident occurred when Callie and George were on a break. For weeks afterward, George gave Callie the cold shoulder. Alex didn't even apologize to the Ortho attending and allowed her to blame Meredith (Ellen Pompeo) and Mark (Eric Dane). He could have ruined George and Callie's relationship.

When Alex first came to the show, he was a very unlikable character. He was crass, rude and very arrogant towards his colleagues, often saying sexist and demeaning things. However, the biggest line he crossed was when he plastered Izzie's modeling photos across the locker room.

Considering he had expressed an interest in the blonde doctor, he went about getting her attention the wrong way. Degrading her for being 'Bethany Whisper', he proceeded to mock her in front of all their colleagues. Even though Alex tried to belittle her, it was great to see Izzie stand up for herself.

For a brief spell, Alex and Jo's (Camilla Luddington) relationship was strained. Jo didn't mind Alex and Meredith's friendship, she just had a problem with the way the General attending treated her. She also didn't like the fact that Alex would always jump to Meredith's defense, even when Meredith did something wrong.

RELATED: Grey's Anatomy: All of Alex Karev's Relationships, Ranked

This is true if fans consider the infamous dinner at Meredith's house where Penny (Samantha Sloyan) revealed she was joining Grey-Sloan. Meredith had her hauling the trash out of the house and Alex doesn't even save her a seat at the table. Even Stephanie (Jerrika Hinton) notices him ignoring Jo. Although they are in a better place now, he didn't treat her with the respect she deserved.

Alex had shown himself to be a supportive husband when Izzie was going through her chemotherapy. He ensured that she attended all her meetings and was eating regularly.

However, Alex let himself down when he revealed how exhausting it was to look after her. Since Izzie's memory seems to be reset, Alex was trying to help her regain her memories. When Izzie notices his frustrations, he reveals that they only got married because they thought she would be dead. He talks about how he feels trapped in the situation they were in now. Although Izzie told him to get it off his chest, he should have told someone else.

Alex was one of the doctors who was traumatized by the shooting in season 6. After getting shot, fans were on tenterhooks to see if he survived. Luckily, they managed to get him to a hospital in time. However, fans were all shocked to discover that he kept the bullet in his chest.

Bailey (Chandra Wilson) was the only doctor who had the sense to pull him up on it. She couldn't understand why he would want a reminder of that day nor risk his health. If the wound got infected, it would have all been for nothing. Regardless if it "attracted tail", the surgeon in Alex should have known better.

After weeks of pursuing Izzie, Alex was finally able to win her over. In season 2, fans saw a softer side to Alex when the couple go on several dates. However, he suffered a crisis of confidence when he struggled to get intimate with Izzie and failed his board exams.

RELATED: Grey's Anatomy: 10 Of The Most Relatable Quotes From Alex Karev

As a result, he cheated on Izzie with nurse Olivia (Sarah Utterback) - the woman he gave syphilis to. What made it worse was that Izzie had been looking for him and walked in on the two mid-hook-up. Any trust built between the two was destroyed.

In season 6, Lexie (Chyler Leigh) and Alex were seen to start a relationship after the Pediatric surgeon's divorce came through. The couple faced their biggest test in the season's finale when Alex had been shot by Gary Clark (Michael O'Neill), who was on the hunt for Lexie, Derek (Patrick Dempsey) and Richard (James Pickens, Jr).

Thanks to Mark and Lexie, Alex came out of the incident alive. However, Lexie soon had a mental breakdown after her PTSD got worse. Instead of helping her through this tough time, Alex abandoned her and left Mark to make the tough decisions. His actions eventually led to the couple breaking up.

Straight from the beginning, everyone knew Alex didn't like George. The pediatric surgeon had a huge feud with O'Malley after he gave George's girlfriend syphilis and continued to belittle him every chance he got. However, even though Alex has shown respect to George occasionally, it has only appeared in the aftermath of his death.

RELATED:Grey's Anatomy: 10 George O'Malley Quotes That Will Make You Miss Him Even More

Alex has confessed that he had disliked the surgeon because he was jealous and insecure about George's skills. He had also told Meredith and Cristina (Sandra Oh) that he doesn't like thinking about George because he's then reminded of Izzie and the pain she left behind when she disappeared. It's a shame that he couldn't tell this to George before it was too late.

Meredith and Alex's friendship is one of the fans' favorites. On several occasions, the pair have been seen as each other's confidants; Meredith became a source of comfort after his divorce to Izzie, whilst Alex provided the same support after Derek's death.

However, their friendship became strained when both began to compete for Chief Resident. Alex revealed to Owen (Kevin McKidd) that Meredith had tampered with the Alzheimer's trial, which caused her to get fired. As a result, Meredith kicked him out of her house. It did take a while for him to earn her trust back.

Fans were horrified when Alex nearly beat Deluca (Giacomo Gianniotti) to death. The Grey-Sloan resident was a victim of a brutal assault after Alex believed he was taking advantage of Jo. Instead of allowing Andrew to defend himself, Alex jumped to conclusions and beat him up.

When Alex was arrested, loyalties at Grey-Sloan were divided. Deluca was ostracized by many doctors, with the resident believing Meredith was blackmailing him to not testify. Everyone was treating Alex as if he was the victim when he was the aggressor; he would have rightly deserved to be put in jail.

NEXT: Grey's Anatomy: 5 Times Alex And Izzie Were The Perfect Couple (& 5 Times They Weren't)

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Grey's Anatomy: The 10 Worst Things Alex Karev Has Ever Done, Ranked - Screen Rant

Former Grey's Anatomy star TR Knight is teaming up with The Big Bang Theory's Kaley Cuoco for new HBO drama The Flight Attendant.

Based on Chris Bohjalian's dark comedy novel of the same name, the upcoming series stars Cuoco as Cassandra 'Cassie' Bowden, a flight attendant who is rather perturbed to find a dead body next to her when she wakes up hungover in a Dubai hotel room.

Knight who starred in Grey's Anatomy as Dr George O'Malley between 2005 and 2009 will be playing Cassie's older brother Davey, who is disapproving of his sister's lifestyle.

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The cast also includes Michiel Huisman (Game of Thrones), Sonoya Mizuno (Maniac), Colin Woodell (The Originals), Merle Dandridge (Greenleaf) and Griffin Matthews (Dear White People).

In other Kaley Cuoco news, it was announced last month that her animated Harley Quinn series will premiere on the DC Universe streaming service on November 29.

The show will also include Veep star Tony Hale, the legendary Wanda Sykes, Doom Patrol star Alan Tudyk and Breaking Bad's Giancarlo Esposito, among others.

Cuoco previously explained what her character will be like in the series, stating: "She goes through growth but it's like a few steps forward and 25 steps back. She falls back in her old ways again and can't really help it.

"The nice thing is that most of the time she's going up against villains who are worse than her. So you root for her in that way. She is a killer but those who are dying in her hands deserve it."

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It was another tragic loss onGrey's Anatomy Season 16 Episode 7.

Maggie met her cousin and lost her in the same day, and she may carry the guilt of not being able to save her. Elsewhere, Catherine put an end to Richard and Gemma's relationship, and Amelia told Owen she was pregnant.

Join TV Fanatics Meaghan Frey and Jasmine Blu, and Grey's Fanatic Berea Orange as they discuss an emotional Grey's Anatomy.

On a scale of 1-10, how emotional was the episode?

Meaghan: 7. It was impossible not to be upset by Sabi's death but at the same time, the emotional impact would have been greater if they let a bond grow between Maggie and her for a few weeks before this happened.

Berea: It was an 8. I was so heartbroken for Maggie and everyone involved.

Jasmine: 8. I was surprised by how attached I was to Sabi, and her death was devastating. I didn't anticipate a death, nor did I expect to be so affected by it.

What did you think of Sabi and how instantly fond she was of Maggie?

Meaghan: She was like a ray of sunshine, and I really enjoyed her. Like I said in my last answer, I wish she had gotten to stick around longer.

I'm Sabrina Webber, and this is my father. Richard is my uncle, and he's your biological father, so we're your family.

Berea: I just loved Sabi. She was the sweetest and instantly bonded with Maggie. It was so nice for Maggie to have someone she could relate to that looks like her. If only for a short time.

I especially loved how she immediately took Maggies side regarding Jackson (I hate him.). We havent seen that kind of solidarity from Meredith and Amelia so far.

Jasmine: She was so pure and sweet! Why couldn't we keep her for a little longer?

It's something special when we meet someone who makes you feel less alone and when someone finally gets you, and Maggie always has a tough time connecting with others, not everyone gets her, but Sabi did.

It was so heartbreaking that she was there and then ripped away so soon.

They were so cute together, and I wish we had more time with them being awkward, nerdy women together.

Do you think Maggie was too persistent and pressured Sabi and Chris?

Meaghan: Yes. I understand that Maggie knows she is an incredible surgeon, but she should have respected their wishes.

At the end of the day, she couldn't save her, so it would have been better for her to not do it and be able to maintain a relationship with Chris.

I know Margaret Pierce and there's not a doctor in this city with half her skill or expertise.

Berea: No, she was not too persistent. Maggie advocates for her patients more than any other doctor at Grey-Sloan. Weve seen her do it for Bailey when the doctors at Seattle Presbyterian werent taking her seriously.

We saw it again when April had her accident and every other doctor in the room (including Jackson) was ready to give up on her.

Maggie kept pushing and saved her life. That is the kind of surgeon she is, and it wasnt her fault she didnt make it.

Jasmine: I didn't think so. I understood why she did it, and the doctors at Pac-North were not good, and it was a pressing matter.

She's the best, and she wanted to do the best for her cousin. I don't think it mattered if she saved Sabi or not; Chris didn't want to be bothered with Maggie at all.

How do you think Sabi's death will affect Maggie going forward?

Meaghan: I think it is going to make her question her skills. Maggie's confidence has always been steadfast, but this is going to shake her.

Berea: This is going to be tough on Maggie for sure. This is her first time meeting a relative who looks like her with whom she immediately bonded. Then she lost her in her OR.

I think we will see her go through a hard time dealing with this. She leaned on Jackson after she lost her mom, and she wont be able to do that this time.

Maggie: Sabrina's condition was critical before she got to the operating room. I did everything I could to save her, but unfortunately, she died. Richard: Oh, Maggie.

Meredith and Amelia all have big things going on in their lives. This might also cause some trouble with Richard, even though she has never had a close familial relationship with him.

I believe we will get some good story moving forward for Maggie as we watch her navigate this loss.

Jasmine: I'm not certain yet, but I'm looking forward to wherever this leads her. It could be a very personal arc that's different than anything we've seen from her.

She lost someone else; she lost a possibility, and there's something more tragic about that then when she lost her mom only because of all the things that could've been.

Maggie: I'm sorry does that woman look like me? Jackson: I don't know, I'll have to see her scowl first.

I think it may lead to her self-reflecting and trying to figure things out in life and what she wants out of it. I don't know; I hope it's good, after all that suffering.

Do you think Owen reacted poorly to Amelia's pregnancy, or do you understand his position/feelings?

Meaghan: I understand it, but at the same time it is in poor taste.

Yes, Owen has the right to feel how he is feeling, but Amelia stepped aside and let him and Teddy be happy together. This is Amelia's chance to be happy.

Berea: I am so sick of Owen.

First, I didnt think she needed to go out of her way to go all the way to Pac-North just to tell him because it really isnt his business.

Objectively, I can see how Owen would feel that initial upset. She told him she didnt want a baby, and here she is having a child with another man.

Now you're telling me that it's not that you didn't want to have kids it's just you never wanted to have them with me.

But he absolutely does not get to yell at her and try to make her feel guilty for finding happiness with someone else. I would love to see how Teddy feels about him being so angry.

Jasmine: Yeah, I understood it and I didn't.

He had a right to feel his feelings, and I felt for him in some ways, but as I said in my review, his feelings were an Owen problem, not an Amelia problem.

Suck that shit up and release the frustration later in the gym or something. Amelia stepped away and let him be happy with Teddy. He has his family and his children; let Amelia find her happiness.

Link and I are having a baby, and you need to know.

Life happens, and people change their minds, and she told him she wasn't ready yet, but she has worked through some of her reservations about having a kid of her own. So, it is what it is.

Did Owen let his personal feelings hinder how he treated Cassidy?

Meaghan: Absolutely. I wanted to throw something at my TV every time he was on the screen.

It was not his place to be making that decision for her. She was very clear in her wishes, and if he wanted an abortion, it isn't his job to tell her no.

Berea: Yes, and this wasnt his first time. He did the same thing in season six with Teddys physician-assisted suicide patient.

He lets his personal views and feelings affect the care for his patients. This woman made it very clear she wanted an abortion and would take dangerous measures to achieve that.

As a doctor, he should have done the right thing to help her achieve this.

Jasmine: Yes. He pissed me off a lot with how he treated Cassidy. He always lets his personal feelings affect his cases and never in a good way. I, too, wanted to throw something at the screen.

Catherine offered Gemma a job anywhere but Seattle. Thoughts?

Meaghan: I don't typically like Catherine, but I loved her at that moment and was cheering her on. Gemma needed to know who she is dealing with.

Berea: I love Catherine Fox. She didnt have to argue or yell or get nasty at all. That job offer said, I am a powerful woman, and its in your best interest to get as far away from me and my husband as soon as possible.

I was here for it. Gemma better watch out.

You're talking an awful lot for someone who says there's nothing to talk about.

Jasmine: I mean, that was a POWER move. It was Queen energy. It was all class and grace, and I squealed when it happened. I'm a huge fan of polite, nice "eff you's."

What was your favorite moment?

Meaghan: Catherine offering Gemma the job. Catherine was a bad bitch at that moment, and I adored it!

Berea: Alex and Maggie after the surgery was my favorite moment.

I love their friendship. He has always been great at being there for her, and that moment where he let her breakdown was so perfect.

Jasmine: I may or may not have been still gushing about it days later on Twitter, but Alex and Maggie after the surgery.

We haven't seen the two of them interact much in ages, but they were always one of my favorite, most underrated relationships on the series.

They have been super close since the year they spent together when Meredith was away, and their relationship is so special to me.

Maggie: I can't do this. Alex: I'll be with you. Maggie: No, I can't. They didn't want me to operate, and I pushed them. I told them I was the best. Alex: You are. Maggie: I can't do this.

I loved how he gave her the time to breakdown, and he went with her to help her deliver the news. Alex has always been a Maggie supporter and cheerleader, and he's one of the only people who always seemed to "get her."

I missed their friendship, and I'm glad we saw it again even if it was under tragic circumstances.

Do you agree with us or disagree?

What are your responses? Hit the comments below!

Grey's Anatomy airs Thursdays on ABC.

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Best known for her roles in Grey's Anatomy and Private Practice, actress Kate Walsh admits her transition between the two primetime dramas wasn't as easy as fans may have thought it was due to personal reasons. In an exclusive interview with PopCulture.com, Walsh revealed that she entered menopause at the age of 39 amid the premiere of Private Practice, "it was a real crazy, crazy time."

"My body started changing," Walsh told PopCulture.com of the chaotic transitions. "Hot flashes and night sweats and mood swings, and sudden tears and 'Oh my God!' And I was just working, I was transitioning from Grey's Anatomy to having my own show on Private Practice. [And] newly married, it was a real crazy, crazy time."

She went on to say how "lonely" and "scared" she felt during that time, not only because it was a wild transition, but because there is an evident lack of social conversation in our society surrounding the epidemiology.

"It was gnarly," she said. "It was really scary to be honest, because there was a lot of information in the culture, [but] there wasn't a lot of support for it. And there was a lot of fear around it and I hated that. I had to sort of learn by just asking random older women like, 'Hey, did you have to do this? What are you doing? How are you doing it?'"

To take a stand and help empower the discussion, the 13 Reasons Why actress partnered with EQUELLE, a company that provides naturally derived, plant-based supplements for women entering and going through menopause. With an objective to raise more awareness about an otherwise not-popular topic of public conversation, Walsh shares she is humbled to be a part of it.

"I think one of the things that freaks women out is like, 'Oh, I either have to do hormone replacement or nothing,'" she said. "And so it's a choice between, you know, one fear or another."

Walsh adds that the one thing she loves the most about the hormone-free supplement is that it is chock-full of natural ingredients, including the S-equol, a naturally derived component from plants that shares a similar structure to estrogen and binds to select estrogen receptors in the body.

"I love that EQUELLE's naturally derived, it's plant-based and it just reacts with our natural estrogen receptors in our body and helps alleviate symptoms of heat, and muscle aches and pains, that come along with menopause," she explained.

Walsh recommends that for many woman going through menopause or those about to enter it, it is important "to breathe and go easy on yourself."

The 52-year-old adds while her schedule remains busy with work, she finds ways to slow down especially when it comes to managing her own symptoms. Even if it's closing her eyes for three to five minutes while taking a couple deep breaths, she says it goes a long way and can really help.

As for what's ahead for Walsh, she is keeping busy with both TV and film, with the upcoming movies, Sell By and 3022 alongside Omar Epps and Miranda Cosgrove. The award-winning actress also teased she's working on a "top secret" project, but couldn't give out any more details than that.

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When Owen Hunt (Kevin McKidd) first appeared on Grey's Anatomy, no one knew what to make of him. However, sixteen years has seen the trauma surgeon engage in a love/hate relationship with fans. Owen has proved to be a kind and generous doctor but lets himself down by cheating on all his partners.

RELATED: Grey's Anatomy: The 10 Worst Things April Kepner Has Done

Is the trauma surgeon a good friend? Yes and No. Owen has provided many of his colleagues with comfort when they have needed it. Yet, if it somehow affects him, he goes out of his way to sabotage their happiness. Keep reading to see the five reasons why he was a bad friend and 5 why he was the best.

The love triangle between Cristina-Owen-Teddy was seen to intensify in season 6 when Owen refused to recommend Teddy (Kim Raver) for the head of cardiothoracic surgery. When Cristina (Sandra Oh) asked Owen to vouch for Teddy since they had begun to form a strong partnership, he promised that he would.

However, he does the exact opposite and tells Derek to hire the other candidate. Owen then leads Cristina and Teddy to believe that he went through with his promise. They eventually found out when Meredith (Ellen Pompeo) discovered the truth. Although he tries to defend himself by saying Teddy is a trigger, Cristina realizes it's because he has feelings for her. It then leads to a huge falling out between the three characters.

When Owen first came toGrey's Anatomy, fans discovered he had PTSD. The writers delved into this history during the episode "Suicide is Painless", documenting his time at war. Hunt recalls the time when his platoon was hit by an I.E.D, killing everyone but the Captain (Richard T. Jones).

Hunt was seen to be close friends with Dan (Jones), so it was no surprise that he was trying his best to save him. Dan tells Owen to let him go, which he refuses to do. He only relents when Dan begs him to because he's in pain. Unfortunately, the recovery team turns ends up succumbing to his wounds.

Henry's (Scott Foley) death hit everybody hard because he was a nice guy. He also made Teddy happy, which was all the fans wanted for her. However, fans knew his days were numbered when the former baseball player began to cough up blood.

RELATED: Grey's Anatomy: 20 Things Wrong With Izzie Stevens We Choose To Ignore

Teddy entrusted Cristina, Webber (James Pickens Jr.) and Owen to look after her husband whilst she was in surgery. Unbeknownst to her, Henry had died in theatre. Owen decided not to tell Teddy at the risk of putting the patient in danger, which she did not forgive him for. It was the right call, but it does make you wonder if he could have called another surgeon in to finish the operation while he told her about Henry.

The friendship between Teddy and Owen was fractured for quite some time after Henry's death. Their relationship was seen to improve near the end as both began to go through a rough patch. However, Owen soon realized that Teddy wanted to leave the hospital but was hesitant to accept a job opportunity because she didn't want to leave him.

Owen was surprised that Teddy was thinking of turning the job down since Grey-Sloan was a constant reminder of Henry. When Owen realizes she's only staying because she's worried about his health, he is forced into action. He fires her 'effective immediately', telling her that she is insubordinate and rebellious. Teddy runs out of the room angry but soon rushes back to thank him for letting her go.

Owen's feud with Riggs (Martin Henderson) had to make the list after the trauma surgeon did everything he could to make his friend feel unwelcome. Hunt was shown to severely dislike the cardiothoracic surgeon, blaming Riggs for the disappearance of his sister. He believed that Megan was kidnapped because she was trying to avoid Riggs after he cheated.

Although they eventually called a truce and his sister was found, Owen was not happy to hear that Nathan and Megan (Abigail Spencer) were planning to start afresh ("Danger Zone"). Having had enough, Megan calls Owen a hypocrite for constantly bringing up Riggs' infidelities, revealing she also cheated too. That whole feud was seemed pointless after this.

Even though their relationship didn't last very long, Owen proved himself to be a pillar for Amelia (Caterina Scorsone). In the aftermath of Derek's (Patrick Dempsey) death, Amelia was seen to struggle. She felt a lot of remorse for not being able to say goodbye to Derek and began to repress her feelings. She almost relapsed amid her grief but confessed to Owen before she could give in to the temptation.

RELATED: Grey's Anatomy: 20 Things Wrong With Alex Karev We All Choose To Ignore

Owen forced her to come to terms with her sadness, making her talk about her feelings. He told her that it was okay to be hurt and upset, which eventually led to the neurosurgeon breaking down in his arms. The trauma surgeon was also by her side when Amelia was about to listen to Derek's final voicemail.

Amelia was right when she said any relationship Owen entered was doomed for disaster. This was because Teddy was always looming about in the back of his mind. Although he denied it, the evidence was clear when he became jealous of her budding relationship with Tom (Greg Germann).

Owen began to pursue Teddy whilst she was with Tom. He didn't like that Tom could be involved in their daughter's life, calling him a "dirtbag" and a terrible father. His behavior gets worse when he embarrasses Amelia in front of their colleagues by getting punched by Tom. She and Teddy deserved more at this moment.

When April (Sarah Drew) and Jackson (Jesse Williams) were going through a divorce, April was at her lowest point. She also found herself under a lot of stress when she found out she was pregnant, with Catherine (Debbie Allen) threatening to sue her for fraud because she kept it a secret.

April tells Owen that one of the reasons she kept it a secret was because she wanted to protect her baby. She tells him that she feels like "everything is screwed up" now that Jackson had found out. Owen is quick to reassure her that having a baby is not a mess, but a miracle. In all the midst of the drama, April realizes that no one seems to have congratulated her on the pregnancy. Owen gives her the first respite from all the drama.

Just recently, Owen has discovered that Amelia was pregnant. Did he offer a friendly congratulations? Nope. Even though Owen is now with Teddy, he wasn't happy about the fact that Amelia had now changed her mind about having children. He makes it about himself, saying she must not have wanted his children because that was the main reason they got divorced in the first place.

Keeping in mind that Amelia had a tumor when they got married, Owen can't hold it against her. They had barely begun dating before they were rushing down the aisle. It was just as much his fault that they didn't discuss their plans for the future.

One of the toughest storylines came in the episode "Hold Back the River" when a patient comes into the ER with cancer. However, Arizona (Jessica Capshaw), Owen and April soon find out that another 'doctor' has falsely led several women to believe they have breast cancer to charge them for the chemotherapy.

Owen and Arizona only find out about this when the fraudster claims the neonatal surgeon has the disease. When Owen sees how the lies have affected Arizona, he storms back to the clinic to confront the so-called doctor. Although he had called the police, he attempts to scare the con artist into admitting his crime.

NEXT: Grey's Anatomy: 10 Of The Worst Things Meredith Grey Has Ever Done

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Grey's Anatomy: 5 Times Owen Was A Bad Friend (& 5 Times They Were Good) - Screen Rant

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Learning Objectives

Human anatomy is the scientific study of the bodys structures. Some of these structures are very small and can only be observed and analyzed with the assistance of a microscope. Other larger structures can readily be seen, manipulated, measured, and weighed. The word anatomy comes from a Greek root that means to cut apart. Human anatomy was first studied by observing the exterior of the body and observing the wounds of soldiers and other injuries. Later, physicians were allowed to dissect bodies of the dead to augment their knowledge. When a body is dissected, its structures are cut apart in order to observe their physical attributes and their relationships to one another. Dissection is still used in medical schools, anatomy courses, and in pathology labs. In order to observe structures in living people, however, a number of imaging techniques have been developed. These techniques allow clinicians to visualize structures inside the living body such as a cancerous tumor or a fractured bone.

Like most scientific disciplines, anatomy has areas of specialization. Gross anatomy is the study of the larger structures of the body, those visible without the aid of magnification (Figure 1a). Macro- means large, thus, gross anatomy is also referred to as macroscopic anatomy. In contrast, micro- means small, and microscopic anatomy is the study of structures that can be observed only with the use of a microscope or other magnification devices (Figure 1b). Microscopic anatomy includes cytology, the study of cells and histology, the study of tissues. As the technology of microscopes has advanced, anatomists have been able to observe smaller and smaller structures of the body, from slices of large structures like the heart, to the three-dimensional structures of large molecules in the body.

Anatomists take two general approaches to the study of the bodys structures: regional and systemic. Regional anatomy is the study of the interrelationships of all of the structures in a specific body region, such as the abdomen. Studying regional anatomy helps us appreciate the interrelationships of body structures, such as how muscles, nerves, blood vessels, and other structures work together to serve a particular body region. In contrast, systemic anatomy is the study of the structures that make up a discrete body systemthat is, a group of structures that work together to perform a unique body function. For example, a systemic anatomical study of the muscular system would consider all of the skeletal muscles of the body.

Whereas anatomy is about structure, physiology is about function. Human physiology is the scientific study of the chemistry and physics of the structures of the body and the ways in which they work together to support the functions of life. Much of the study of physiology centers on the bodys tendency toward homeostasis. Homeostasis is the state of steady internal conditions maintained by living things. The study of physiology certainly includes observation, both with the naked eye and with microscopes, as well as manipulations and measurements. However, current advances in physiology usually depend on carefully designed laboratory experiments that reveal the functions of the many structures and chemical compounds that make up the human body.

Like anatomists, physiologists typically specialize in a particular branch of physiology. For example, neurophysiology is the study of the brain, spinal cord, and nerves and how these work together to perform functions as complex and diverse as vision, movement, and thinking. Physiologists may work from the organ level (exploring, for example, what different parts of the brain do) to the molecular level (such as exploring how an electrochemical signal travels along nerves).

Form is closely related to function in all living things. For example, the thin flap of your eyelid can snap down to clear away dust particles and almost instantaneously slide back up to allow you to see again. At the microscopic level, the arrangement and function of the nerves and muscles that serve the eyelid allow for its quick action and retreat. At a smaller level of analysis, the function of these nerves and muscles likewise relies on the interactions of specific molecules and ions. Even the three-dimensional structure of certain molecules is essential to their function.

Your study of anatomy and physiology will make more sense if you continually relate the form of the structures you are studying to their function. In fact, it can be somewhat frustrating to attempt to study anatomy without an understanding of the physiology that a body structure supports. Imagine, for example, trying to appreciate the unique arrangement of the bones of the human hand if you had no conception of the function of the hand. Fortunately, your understanding of how the human hand manipulates toolsfrom pens to cell phoneshelps you appreciate the unique alignment of the thumb in opposition to the four fingers, making your hand a structure that allows you to pinch and grasp objects and type text messages.

Human anatomy is the scientific study of the bodys structures. In the past, anatomy has primarily been studied via observing injuries, and later by the dissection of anatomical structures of cadavers, but in the past century, computer-assisted imaging techniques have allowed clinicians to look inside the living body. Human physiology is the scientific study of the chemistry and physics of the structures of the body. Physiology explains how the structures of the body work together to maintain life. It is difficult to study structure (anatomy) without knowledge of function (physiology). The two disciplines are typically studied together because form and function are closely related in all living things.

1. Which of the following specialties might focus on studying all of the structures of the ankle and foot?

2. A scientist wants to study how the body uses foods and fluids during a marathon run. This scientist is most likely a(n) ________.

1. Name at least three reasons to study anatomy and physiology.

2. For whom would an appreciation of the structural characteristics of the human heart come more easily: an alien who lands on Earth, abducts a human, and dissects his heart, or an anatomy and physiology student performing a dissection of the heart on her very first day of class? Why?

Answers for Review Questions

Answers for Critical Thinking Questions

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1.1 Overview of Anatomy and Physiology - opentextbc.ca

the study of the body and its parts. anatomist, n. anatomical, adj.

Obsolete, human anatomy.

the study concerned with the measurements of the proportions, size, and weight of the human body. anthropometrist, n. anthropometric, anthropometrical, adj.

Physiology, Rare. the labeling of the type of body structure by nonanthropometric means.

the anatomy of the human body. anthropotomist, n. anthropotomical, adj.

Physiology. the study of aponeuroses, membranes that can serve as muscle sheaths or as connectors between muscles and tendons.

the scientific description of the arterial system. arteriographic, arteriographical, adj.

a written work on the ligaments of the human body. desmographic, desmographical, adj.

the branch of anatomy and physiology that studies secretions and the secretory glands.

an abnormal physical condition characterized by extensive structural defects of the skeleton and by gross mental deficiency.

the description of the structure and function of the liver. hepatographic, hepatographical, adj.

the description of the structure and function of kidneys. heprographic, heprographical, adj.

a branch of anatomy that deals with the microscopic features of animal and plant tissues. Also called microscopical anatomy. histologist, n. histological, adj.

the scientific description of the larynx. laryngographic, laryngographical, adj.

histology.

the measurement of muscular phenomena, such as the velocity and intensity of muscular contractions. myographic, adj.

1. the branch of anatomy that studies muscles and musculature.2. the muscular makeup of an animal or anatomical unit. myologic, adj.

the scientific description of the organs of plants and animals. organographist, n. organographic, organographical, adj.

the branch of anatomy that studies the skeleton and bones. osteologist, n. osteologie, osteological, adj.

the study of pelvic structure. pelycologic, pelycological, adj.

the scientific description of the pharynx. pharyngographic, pharyngographical, adj.

1. an account of the structure and function of the lungs.2. the recording of the activity of the lungs during respiration. pneumograph, n. pneumographic, pneumographical, adj.

1. a person who dissects cadavers for the purpose of anatomical demonstration.2. a person who performs autopsies. prosectorial, adj.

the branch of anatomy that studies the viscera.

an anatomical treatise on or description of the joints and ligaments of the body.

1. the anatomy of the ligaments of the body.2. the science or study of ligaments.

the condition of having a series of similar parts with the same spatial orientation, e.g. the ribs. syntropic, adj.

the joining of two or more bones by muscle.

1. the dissection of animals other than man.2. the anatomy of animals. zootomist, n. zootomic, zootomical, adj.

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