Category Archives: Anesthesiology

What Exactly Is an Anesthesia ‘Cocktail’? – Medpage Today

Anesthesiology resident Max Feinstein, MD, discusses common medications used in anesthesia and their effects.

Following is a transcript:

Feinstein: Anesthesiologists sometimes tell patients that they are getting a "cocktail" of medications prior to their procedure, which can sound mysterious and intriguing, when in reality this cocktail is typically just comprised of a single medication called midazolam.

My name is Max Feinstein and I'm an anesthesiologist filming here at the Mount Sinai Hospital in New York City and in this video I demystify the medications that are administered to patients prior to procedures. If you find this video interesting or helpful, I'd really appreciate it if you liked it and subscribe to the channel. Let's dive in.

Before we get too far, just a quick reminder that this video does not contain medical advice; it's just a YouTube video. If you need medical advice, you should talk to your doctor.

Midazolam has several very important properties, which are why anesthesiologists use it. The first of those properties is anxiolysis, which is just a way of saying that it can reduce a person's anxiety. This is, of course, very helpful coming into the operating room if a person is nervous about getting surgery, which is very often the case for understandable reasons.

Another useful property of midazolam is that it can cause anterograde amnesia, meaning that patients won't remember anything after they have received the medication. There is an important distinction between anterograde amnesia, which means not remembering something after the medication has been administered, versus retrograde amnesia, which means not remembering something prior to the medication being administered. Midazolam only causes anterograde amnesia, and even then it doesn't necessarily cause amnesia in all patients. It can depend on the dose of medication that's given as well as patient factors like how much they weigh and whether they consume alcohol, which can have cross-tolerance with midazolam.

Midazolam can be used as a primary anesthetic in cases of light or moderate sedation where the goal is to have the patient still conscious and breathing on their own, but just very relaxed. Midazolam is also used frequently as a precursor to general anesthesia where a patient is completely unconscious and not aware of anything that's going on at all. The amount of midazolam that would need to be administered to produce a depth of general anesthesia is impractical in most cases, and so for that reason when patients do receive general anesthesia, there are other agents that are used such as propofol and sevoflurane.

In a small number of cases, there are other medications that can be administered either in lieu of or in conjunction with midazolam. One of those medications that anesthesiologists sometimes reach for is an opioid called fentanyl, which is also short-acting. Generally speaking, anesthesiologists like to reach for short-acting medications because that can help us maintain fine control over physiologic parameters like heart rate, blood pressure, and respiratory status.

When we do include fentanyl as part of the anesthesia cocktail, that's typically because the patient might be in pain and that might be the reason that they are coming in for surgery, for example, if they broke a bone. Anesthesiologists do have to use caution when mixing midazolam with opioids because together those can cause significant amount of respiratory suppression. If the plan is for the patient to undergo general anesthesia, where they're going to be intubated and mechanically ventilated, then respiratory suppression is kind of a moot point, but it is very important for patients to be able to breathe on their own in the time period immediately prior to undergoing general anesthesia.

Another medication that can be used as part of the anesthesia cocktail is a very low dose of propofol, which when given in 10 or 20 mg increments, won't produce general anesthesia in an adult but will actually just produce anxiolysis and perhaps a bit of amnesia. Having said that, propofol can irritate the vein where it's injected, which can be a reason to avoid giving more propofol to an awake patient than they need.

When I mentioned that midazolam is fast-acting, I mean onset can be 2 minutes or less when given through the IV. It typically won't last for more than an hour, although again that also varies depending on the patient. For adult patients, midazolam is typically administered through an IV, which is placed of course while the patient is completely awake. But for pediatric patients who won't tolerate having an IV placed while they are awake, then we can actually administer an oral form of midazolam, but it has a longer time of onset closer to around 20 minutes or so, again depending on the dose and the patient.

One of the common misconceptions around the anesthesia cocktail is that it's a sort of truth serum that causes patients to just blurt out their deepest darkest secrets. In reality, midazolam typically just causes patients to feel relaxed, chill out, maybe giggle a little bit about things that otherwise aren't that funny, and only extremely rarely do patients become disinhibited enough to start saying things that perhaps they wouldn't have said prior to receiving midazolam.

David: I... I feel funny. Is this going to be forever?

Feinstein: But honestly, I have never had a patient actually disclose anything really that embarrassing while they have been under the effects of midazolam or any other anesthetic agent. It's pretty uncommon.

I mentioned that some patients don't remember much, or anything, after they receive midazolam and I think it's really important for anesthesiologists to make patients understand that that may or may not happen once the medication goes in. Expectation setting is a really important part of the patient experience after all.

By the same token, I think it's very important for anesthesiologists to tell patients when they are receiving midazolam or any other medication that's going to change the way that they feel. I don't think it's really fair to surprise patients with medications through their IV without first telling them that they are about to get something that will change the way they feel. While the vast majority of patients who receive midazolam will feel pretty chilled out, there is a small proportion of patients who have what's called a paradoxical reaction where they become hyper-energetic after receiving the medication.

David's Dad: Stay in your seat.

David: [OUTBURST]

Feinstein: If you're a patient watching this video and you're wondering will you receive midazolam or any other medication as part of the anesthesia cocktail before your procedure, the answer is it depends.

Certain aspects of anesthesia practice can vary pretty considerably depending on factors like who your anesthesiologist is, what procedure you're coming in for, what medications and monitoring are available for patients prior to going into the operating room, and so forth. For these reasons, it wouldn't be surprising to me to know that a patient who is coming in for, say, a laparoscopic appendectomy at a certain hospital would probably not be offered midazolam unless there were extenuating circumstances. Whereas a different hospital that has different practice norms would routinely offer midazolam to patients who are coming in for the same procedure.

I do think this variation in practice begs an important philosophical question about the involvement that patients have with regard to the specific medications that they get for their anesthesia and also the extent to which anesthesiologists are involving patients in the decision about what medications will be administered.

On the one hand, I think there is a lot of benefit for anesthesiologists and their patients to have an open conversation about what medications will be administered and why, but then on the other hand that's also not entirely feasible, especially if a patient is under general anesthesia. And there is also an argument to be made for the fact that it can be overwhelming for patients to have to make medical decisions about the specifics of exactly what they are receiving as part of their anesthetic plan that might overall make the experience more anxiety-inducing than it needs to be, as opposed to simply leaving the decisions to the anesthesiologist about how best to produce the outcome that the patient desires, for example, feeling relaxed or being completely unconscious for a procedure.

If you are a patient and you do have any questions or concerns about any part of your anesthesia plan, then it's important to bring it up with your own physician before you undergo your procedure.

Max Feinstein, MD, is a PGY-4 anesthesiology resident at the Mount Sinai Hospital in New York City, where he is also chief resident of teaching. His YouTube channel focuses on perioperative medicine, especially the role of the anesthesiologist.

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What Exactly Is an Anesthesia 'Cocktail'? - Medpage Today

Anesthesiology marks accomplishments in its annual report | Newsroom – University of Nebraska Medical Center

The UNMC Department of Anesthesiology has released its annual report an homage to the many accomplishments of the departments faculty, house staff and dedicated nurse anesthetists.

Read the report here.

The report highlights multiple new leaders, faculty and staff members, clinical division updates and the departments significant contributions to educational and research missions.

In his final message from the chair, Steven Lisco, MD, said it has been a privilege to lead the department for the past 11-plus years.

As many know, Oct. 31, 2023, was my last official day as chair. While I remain a faculty member in this amazing department, my efforts will be focused on my new UNMC College of Medicine and Nebraska Medicine leadership roles, Dr. Lisco said. Words cannot express how thankful I am to have had the honor of serving as chair of this tremendous department.

We are very proud of the accomplishments of our team members. The department is on strong footing because of its outstanding individuals and the innovative spirit, Mohanad Shukry, MD, PhD, interim chair of the department, said. We are also grateful to Dr. Lisco for getting the department to this point and look forward to the future together as a team.

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Anesthesiology marks accomplishments in its annual report | Newsroom - University of Nebraska Medical Center

Anesthesiology Ranked No1 NIH funding nationwide for 2024 | Department of Anesthesiology, Perioperative and Pain … – Stanford Medical Center Report

February 2024

Since 2006, the Blue Ridge Institute for Medical Research has published a ranking of academic departments based on NIH funding to identify institutions, departments, and individuals leading the way in medical research. The rankings are a widely tracked measure of impact and Stanford Department of Anesthesiology, Perioperative and Pain Medicine is thrilled to have been ranked the number one department for research funding in 2023. The departments mission, vision, and values underline a commitment to innovating and transforming the field of anesthesiology and pain medicine and remain exceptionally proud of the team of investigators and staff we have working to advance these goals.

In addition to the departments number one ranking, three of our esteemed faculty were ranked in the top 10 PIs nationally this year: Drs. Jen Hah, Tony Anderson, and Laura Simons.

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Anesthesiology Ranked No1 NIH funding nationwide for 2024 | Department of Anesthesiology, Perioperative and Pain ... - Stanford Medical Center Report

New database of more than 83000 surgical outcomes aimed at advancing research and training artificial intelligence … – UCLA Health Connect

A team of researchers from UCLA and UC Irvine have created a unique repository of electronic health record data and high-fidelity physiological waveform data from tens of thousands of surgeries that will integrate artificial intelligence to improve patient outcomes.

The project led is by Dr. Maxime Cannesson, professor and chair of anesthesiology and perioperative medicine at the David Geffen School of Medicine at UCLA; and Dr. Pierre Baldi, Distinguished Professor of information and computer sciences and Dr. Joe Rinehart, clinical professor of anesthesiology, both at UC Irvine. It is freely available to legitimate researchers who sign a data use agreement (DUA).

All data in the repository, called the Medical Informatics Operating Room Vitals and Events Repository (MOVER), has been stripped of patient identifiers in accordance with patient privacy laws. It can be downloaded athttps://doi.org/10.24432/C5VS5G

The team has published a paper describing the database and its uses in JAMIA Open.

We expect it to help the research community to develop new algorithms, new predictive tools, to improve the care of surgical patients basically globally, Cannesson said. Its the first time a surgical database like this has been released. Its a very wide spectrum of surgeries.

The repository, which had been in the works since 2012, fills a gap in publicly accessible databases that researchers can use to train and test AI algorithms.It is intended to advance a wide variety of healthcare research and serve as a resource to evaluate new clinical decision support and monitoring algorithms for patients undergoing surgery and anesthesia.

It contains data, collected over seven years, of hospital visits for patients undergoing surgery at UCI Medical Center, consisting of comprehensive electronic health record and high-fidelity physiological waveforms. Waveforms are data from monitors such as EKGs that measure the physiology of the patient either minute by minute or sometimes in real time, for instance during a high-risk surgical procedure.

Specifically, the dataset contains general information about each patient and their medical history, including details about the surgical procedure, medicines used, lines or drains utilized during the procedures, and postoperative complications. In all, it now contains data from nearly 59,000 patients who underwent about 83,500 surgeries.

This information is truly information that physicians and the care team use to make clinical decisions in the acute care setting, Cannesson said. Before this there was no single repository where a very, very large volume of data that includes the physiological waveforms are accessible to researchers.

The MOVER team took the project through a rigorous process to ensure that patient privacy is preserved.

Patient privacy has been at the forefront of the development of MOVER, Cannesson said. Its been through a lot of de-identification process. There is no patient identifier, no date of surgery. Patients above 90 years old, their age is not available. So its been through a lot of de-identification to make sure that no patient identifier is available.

There is a precedent for sharing datasets like this for patients in the intensive care unit, the largest and most widely known being MIMIC, which also includes de-identified electronic health record patient information and waveforms, he noted. Our main innovation was to start more than 10 years ago recording these waveforms during surgery, he said. This could be helpful to the whole perioperative surgical community.

At this point the focus is on sharing the UC Irvine information with qualified physicians and researchers, he said. But a National Institutes of Health initiative called Bridge to AI, of which UCLA is a part, aims to standardize this data across multiple institutions to eventually create a single repository with the same vocabulary and data architecture.

It is designed so that the data can be thoroughly checked, achieving transparency. The goal is eventually to increase the trust that clinicians and patients have with what you are going to see in the near future the development of more and more artificial intelligence-based models, especially for the surgical setting, Cannesson said.

The work was supported by the National Institutes of Health (NIH) through the National Institute of Biomedical Imaging and Bioengineering (R01EB029751).

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New database of more than 83000 surgical outcomes aimed at advancing research and training artificial intelligence ... - UCLA Health Connect

Anesthesiologist arrested for alleged sexual assaults in Putnam County – News 12 Westchester

Jan 03, 2024, 5:24pmUpdated 5d ago

A Putnam County anesthesiologist has been arrested and accused of using anesthesia to sexually assault a woman several times over the course of a month.

Paul Giacopelli, 59, was arraigned in Southeast Town Court Saturday on four counts of first-degree sexual abuse and four counts of second-degree assault.

Investigators with the Putnam County Sheriff's Office told News 12 the assaults happened during December and that all the charges relate to multiple assaults of the same woman.

Giacopelli works for Northwell Health and has privileges at Putnam County Hospital Center in Carmel. He is a New York Medical College graduate and is certified to practice by the American Board of Anesthesiology.

Putnam County Sheriff Kevin McConville said in a release that investigators on Dec. 29 interviewed a female victim who told them she was given anesthesia without her knowledge and then sexually assaulted. The next day, Giacopelli was interviewed and then arrested. Officials said the victim and Giacopelli know each other.

Giacopelli made bail Tuesday, officials said.

News 12 went to Giacopelli's most recent address in Brewster and called several numbers associated with him seeking a response to the allegations but has not heard back from Giacopelli.

Northwell Health issued a statement late Wednesday stating in part that Giacopelli "was immediately relieved of all patient care duties pending further investigation. We will cooperate with the appropriate authorities as they conduct their investigation."

Investigators are asking anyone who might have information on these incidents or other possible incidents to call their office immediately at 845-808-4377.

Giacopelli is due back in Southeast Town Court on Jan. 11.

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Anesthesiologist arrested for alleged sexual assaults in Putnam County - News 12 Westchester

Comparing characteristics and perspectives of U.S. anesthesiology fellows in training and anesthesiologists in their first … – BMC Medical Education

A career in anesthesiology provides an opportunity for a varied, stimulating and fulfilling practice and has been popular as a specialty choice for graduating medical school students in the U.S. and elsewhere [11]. Residents in anesthesiology report satisfaction with their training [8], and many experienced anesthesiologists remain enthusiastically engaged in their work. Nevertheless, the profession of anesthesiology faces challenges and our survey study evaluated the perceptions of first-year graduates of U.S. anesthesiology residencies on this issue. The main finding was that these early career anesthesiologists perceived challenges fell into three broad themes - workforce competition from non-physician anesthesia providers and unease about external perception of anesthesiologist value, changes in the healthcare system that led to concerns about lower compensation and threats to patient care, and personal stressors including disquiet over burnout and the need to meet professional standards. These results highlight issues for programs and organizations to address. The perceived challenge to employment security posed by CRNAs and the perceived lack of appreciation for anesthesiologist value were most frequently cited. Although both AFs and DEs had similar concerns about the profession of anesthesiology, the relative weighting of their worries was different and may be the reasons behind or a consequence of their decision to pursue or not pursue a fellowship.

Demographic characteristics of AFs and DEs were similar and reflective of the life-stage of typical North American residency graduates. The influence of family factors on the decision to enter fellowship has previously been documented by Khan et al. among Canadian anesthesiology residents [6]. Having children may be a disincentive to fellowship because of the work hours involved, on-call responsibilities, and the unpredictability of these responsibilities. We suggest that implementation of measures to make fellowships more accommodating to anesthesiologists with, or intending to have, children would encourage more residents to consider that path [12]. Such measures might include enhancement of schedule flexibility, more accommodating leave-of-absence policies, support for nursing mothers, and improved access to childcare [13,14,15]. A greater amount of educational debt decreases the likelihood of a physician selecting a post-residency academic position and increases residency graduates interest in anesthesiology groups with an educational debt repayment program [3, 16, 17]. Although student debt was not reported as a major challenge in this study and debt burden was similar among AFs and DEs, those who chose to go directly into independent practice were slightly older, had more dependents, and were more likely to have a spouse who did not work outside the home, factors that may have influenced a perceived imperative to achieve financial security for their families. Although statistically significant, these differences were modest, and it is not clear that such modest differences would be determinative in making such an important life decision. Consistent with previous reports [7], a substantial proportion of respondents were not satisifed with their personal and professional life balance, although DEs expressed greater satisfaction than AFs.

From the perspective of U.S. anesthesiology residency graduates, the greatest challenge to the profession of anesthesiology identified from free-text comments was competition from non-physician anesthesia providers, the subject of more than half of all comments. This level of concern does not appear to be a new phenomenon [18, 19], but its persistence is striking. Of interest, compared to when these cohorts were CA-3 residents [2], AFs in training were slightly more concerned about this workforce competition while DEs were less concerned. We speculate that some DEs had seen first-hand how a highly functioning collaborative practice could work, whereas fellows lacked the real world experience and were apprehensive about their unknown post-fellowship employment. Providing more opportunities for fellows to participate in collaborative practice with advanced practice providers may help ease such concern and better prepare them for the care team they may lead in their future practice. Previous work has demonstrated the vulnerability and discrimination experienced by female anesthesiologists worldwide [20, 21]. Although many female DEs in our study were concerned about a perceived lack of differentiation between anesthesiologists and CRNAs (approximately 60% of CRNAs are female) [22], the proportion relative to other groups was not statistically significant. It was notable that those DEs who practiced predominantly in the care team model in a large practice (i.e., infrequently or never personally administered anesthesia as the sole provider) were more likely to raise a concern about the external perception of anesthesiologist value and a perceived lack of advocacy for the profession [23, 24]. To alleviate the concern, professional organizations and major hospitals could use diverse platforms and channels, including participation in medical conferences, strategic engagement on social media, and featured content in healthcare publications, to spotlight the contributions and expertise of anesthesiologists and foster a broader understanding and appreciation of their role in healthcare.

The choice of fellowship influenced the perception of competition from non-physician anesthesia providers. Advanced training was seen by some as a means to further differentiate anesthesiologists from non-physicians. Subspecialty training in either critical care medicine or cardiac anesthesiology was associated with a lower concern about workforce competition. Critical care medicine practice seems to be sufficiently different from operating room anesthesia that fellows feel assured that their physician subspecialty skills are more difficult to replace. Indeed, we previously documented that anesthesiology residents considered their critical care rotation as one of the most important rotations in clinical anesthesia training [8]. Although nurse practitioners increasingly deliver care in intensive care units, such individuals are usually not CRNAs. We also postulate that the routine integration of echocardiography training into cardiac anesthesiology fellowship helps differentiate the role of the cardiac anesthesiologists from that of the cardiac operating room CRNAs, which results in a decrease in the competition concern. Less easily explained, however, is that pain medicine fellows had the highest concern about workforce competition. Perhaps an explanation lies in the increasing number of non-anesthesiologist physicians and non-physicians who provide care in pain management [25, 26] in the U.S. and thus a heightened sensitivity to this issue among anesthesiology pain medicine fellows and consultants.

Within the second identified theme of healthcare system changes, concerns relating to financial compensation were most prominent. Many responses included specific concerns about decreasing reimbursements and bundled payments. Although female anesthesiologists salaries are 512% lower than those of male anesthesiologists [27] and female anesthesiologists face inequity in clinical practice [28], it was the male respondents in our cohort who were more likely to express concerns about compensation. DEs in large practices who often or exclusively perform their own cases were especially concerned about their renumeration. We speculate that their lack of a multi-room supervisory practice made these anesthesiologists feel vulnerable to identification as an in-room provider, similar to a CRNA or AA, with subsequent concern that they would be compensated at lower rates than those anesthesiologists whose practice model allows them to bill for simultaneous cases. Finally, our data, analyzed according to four U.S. regions of respondent practice location, demonstrated that compared to DEs in the northeastern region, those in the Southeast and West were more concerned about compensation. This may be partly due to regional differences in the anesthesiology workforce and the location-specific ratio of CRNAs to anesthesiologists [29, 30]. Although anesthesiologists are well compensated, our findings suggest that financial challenges are of significant concern at the outset of a career in the profession.

Although respondents had free range to identify any perceived challenges to the profession and to them, it is reassuring and concerning - that primacy of patient welfare was highlighted as the principal challenge by about 8% of respondents. Threats to patient care were identified especially by those in the high acuity subspecialty of cardiac anesthesiology and those in large- and medium-sized groups who frequently or exclusively performed their own cases. One could speculate that this may be reflective of concerns held by those anesthesiologists who are routinely charged with caring for the most complex cases in what they perceive are increasingly corporate systems that prioritize economies and efficiencies.

The findings of our report are consistent with data obtained from senior anesthesiology residents as part of the ABA sequential cross-sectional survey study [2]. Similar themes were identified in that cohort, with work force competition from non-physician anesthesia providers being perceived as the greatest threat to the profession, followed by changes in the healthcare system and personal challenges. AFs, DEs, and senior anesthesiology residents were similarly concerned with undervaluation of anesthesiologists by others and lack of advocacy for physician values, an advocacy role more prominent than in any other medical specialty in the U.S.

As we have discussed in previous publications, our analyses based on repeated cross-sectional surveys are subject to limitations [2, 7, 8]. Of special relevance to the evaluation of perceived challenges to the profession was the potential for respondent bias, possible sources of which include subjective views of themselves, their practice, or the profession, and a deliberate portrayal of a specific view to the ABA. For example, respondents may have been reluctant to talk about their own compensation, but more willing to raise concerns about undervaluation of anesthesiologists. Additionally, although we strived to follow best practices of data collection and analysis, the free-text responses were open to interpretation, especially those that were brief and did not elaborate on the context. Our methodology allowed measurement of the frequency with which concerns were spontaneously expressed but not the prevalence of those concerns within the cohort. Respondents had to identify the greatest challenge facing the profession of anesthesiology; they would not likely have reported all challenges that may have been important to them. Further, our data reflect the views of U.S. anesthesiologists and were collected before the COVID-19 pandemic as part of a repeated cross-sectional study of stable cohorts, and do not reflect views of anesthesiologists outside of the U.S. or changes that may have occurred since the onset of the pandemic. Some of the post-pandemic changes in the U.S. include shortages of both anesthesiologists and CRNAs, upward compensation adjustments because of those shortages, and consolidation and increased corporatization of practices. Future studies could utilize the results of this study to make comparisons about how the challenges and perceptions have changed since the COVID-19 pandemic.

In summary, our data provide insight into the characteristics of AFs and DEs and their perception of challenges to the profession of anesthesiology in the U.S. The demographic characteristics of these two groups were largely similar. Although differences in age and family factors may suggest possible motivations for choosing fellowship or not, the importance of these small differences is uncertain. Our investigation of free-text responses to the question of the greatest challenge facing anesthesiology highlighted three major themes in descending order of frequency: workforce competition, healthcare system changes, and personal challenges. Members of the AF and DE groups shared these same concerns, but the relative weighting of these concerns was different and influenced by demographic and professional variables such as gender, fellowship subspecialty, and independent practice characteristics. These physicians represent the next generation of anesthesiologists in the U.S., who will drive the future directions of the specialty. We hope that our identification of the challenges they face and their concerns will inform advocacy and policies at programmatic and professional organizational levels.

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Comparing characteristics and perspectives of U.S. anesthesiology fellows in training and anesthesiologists in their first ... - BMC Medical Education

The Impact of a New Anesthesiology Residency Program on the Number of Medical Students Matching Into … – Cureus

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The Impact of a New Anesthesiology Residency Program on the Number of Medical Students Matching Into ... - Cureus