Category Archives: Biochemistry

Biochemistry

Unraveling the protein map of cell’s powerhouse – ASBMB Today

Mitochondria, the so-called powerhouse of the cells, are responsible for the energy supply of the organism and fulfill functions in metabolic and signaling processes. Researchers at the University Hospital Bonnand the University of Freiburg have gained systematic insight into the organization of proteins in mitochondria. The protein map of mitochondria represents an important basis for further functional characterization of the powerhouse of cell and thus provide implications for diseases. The study has now been published in the renowned scientific journal Nature.

Mitochondria are among the most important cell compartments. They are delimited organelles surrounded by a double membrane. Mitochondria are considered the powerhouse of the cell, as they produce the majority of the energy required for all cellular processes. In addition, they take over many other functions in metabolism and provide a signaling surface for inflammatory processes and programmed cell death. Defects in mitochondria lead to numerous diseases, especially of the nervous system.

Model of the quality control mechanism for removing arrested proteins from the mitochondrial entry gate.

Therefore, the molecular understanding of mitochondrial processes is of highest relevance for basic medical research. The molecular workers in the cell are usually proteins. Mitochondria can contain around 1,000 or more different proteins. To execute functions, several of these molecules often work together and form a protein machine, also called a protein complex. Proteins also interact in the execution and regulation of molecular processes. Yet little is known about the organization of mitochondrial proteins in such complexes.

The research groups of Thomas Becker and Fabian den Brave at the UKB, together with the research groups of Bernd Fakler, Uwe Schulte and Nikolaus Pfanner at the University of Freiburg, have created a high-resolution image of the organization of proteins in protein complexes, known as MitCOM. This involved a specific method known as complexome profiling to record the fingerprints of individual proteins at an unprecedented resolution. MitCOM reveals the organization into protein complexes of more than 90% of the mitochondrial proteins from bakers yeast. This allows to identify new proteinprotein interactions and protein complexes an important information for further studies.

Researchers at UKB in cooperation with Collaborative Research Center 1218 (Regulation of cellular function by mitochondria)have shown how this dataset can be used to elucidate new processes. Mitochondria import 99% of their proteins from the liquid portion of the cell, known as cytosol. In this process, a protein machinery called the TOM complex enables the uptake of these proteins through the membrane into the mitochondria. However, it is largely unclear how proteins are removed from the TOM complex when they get stuck during the transport process. To elucidate this, the team led by Becker and den Brave used information from the MitCOM dataset. It was shown that non-imported proteins are specifically tagged for cellular degradation. Research by the Ph.D. student Arushi Gupta further revealed a pathway by which these tagged proteins are subsequently targeted for degradation. Understanding these processes is important because defects in protein import can lead to cellular damage and neurological diseases.

The example from our study demonstrates the great potential of the MitCOM dataset to elucidate new mechanisms and pathways. Thus, this map of proteins represents an important source of information for further studies that will help us to understand the functions and origin of the cells powerhouse, saidBecker, director of the Institute of Biochemistry and Molecular Biology at UKB.

This article was first published by University Hospital Bonn. Read the original.

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Unraveling the protein map of cell's powerhouse - ASBMB Today

Biochemistry

Celebrating undergrad thesis research at Barrett, The Honors … – ASU News Now

April 5, 2023

Chloe Leff, a junior in Barrett, The Honors College at Arizona State University, has been awarded the Goldwater Scholarship, the most prestigious award in the United States for undergraduate researchers in the natural sciences, engineering and mathematics, or STEM.

The Goldwater Scholarship was established in 1986 by Congress to serve as a living memorial to honor the lifetime work of Arizona Sen. Barry Goldwater. The scholarship helps ensure that the U.S. continues to produce the worlds leading scientists and engineers. Chloe Leff, an ASU junior pursuing dual bachelor degrees in biochemistry and molecular bioscience and biotechnology, has been awarded the Goldwater Scholarship, the most prestigious award in the United States for undergraduate researchers in the natural sciences, engineering and mathematics. Download Full Image

If you are an undergrad in STEM, the Goldwater Scholarship is the big prize, said Kyle Mox, associate deanat theLorraine W. Frank Office of National Scholarships Advisementand the designated campus representative for the Goldwater Scholarship. In addition to a $7,500 stipend, winning a Goldwater carries immense prestige and positions you for admission to top-tier PhD programs and other major fellowships, like the Rhodes Scholarship, Churchill Scholarship or NSF Graduate Research Fellowship.

Of the 2022 ASU Goldwater cohort, two seniors, Claire Blaske and Jasmin Falconer, were recently selected for the NSF program, and senior Katie Pascavis was selected as a Marshall Scholar.

Receiving the Goldwater Scholarship is a huge honor, not just for the recognition of what I have achieved as an undergraduate, but for the vote of confidence in my abilities to succeed in research, Leff said. I want to pursue a career in research, so receiving the Goldwater Scholarship is an added boost of confidence and testament to my capability as a researcher.

Leff, an Arizona native and graduate of Hamilton High School, is pursuing dual bachelor degrees in biochemistry and molecular bioscience and biotechnology. After graduation, she plans to pursue a PhD in immunology and conduct medical research pertaining to disease treatments, particularly cancer.

Since 2021, she has been a member of the Hariadi Lab in the Biodesign Institute, where she assists with research on the use of DNA nanostructures to decrease the infectivity of viruses. In the summer of 2022, as a participant in the DAAD-RISE program, she worked at Justus-Liebig University in Gieen, Germany, contributing to a project that investigates the impact and mechanism behind two synergistic cancer drugs.

Outside of her research work, she serves as the director of events for the Barrett Sustainability Club, is the president of the Gammage Scholars and plays for the ASU womens club soccer team.

Although the national submission deadline for the Goldwater Scholarship occurs annually at the end of January, the ASU scholarship office begins the recruitment and advising process in October.

Each college or university may nominate only four students per year to the Goldwater Scholarship, so the scholarship office establishes a preliminary deadline in early December.

In reality, the most difficult part of the process is receiving a nomination, Mox said. We have so many talented, motivated STEM majors at ASU, and there are ample opportunities to get significant undergraduate research here.

The applications are then reviewed by members of a long-standing faculty nominating committee, who evaluate the candidates academic records, research achievements and letters of recommendation.

I am so grateful to have been one of ASU's nominees, Leff said. Having worked in undergraduate research at ASU for nearly two years, it is an honor to be recognized as a high-achieving student by my university and community of scientists. ASU gave me my first opportunities in undergraduate research, so it is a privilege to be able to represent the university in a national competition centered around excellence in STEM.

The planning, drafting and revision process can be arduous. The Goldwater application requires multiple short essay responses and a three-page research proposal, in which applicants summarize their previous research and describe their future research goals. Throughout the process, applicants seek advice and guidance from the scholship office and their faculty members.

I found that the application process was a great opportunity to reflect on the reasons why I am so drawn to science and research, Leff said. For as long as I can remember, a career in some sort of science was in my future, but having to clearly articulate that passion and clarify how it has transformed into a desire to pursue research specifically encouraged me to recognize how that path reflected my values.

Over the past decade, 21 Sun Devils have been awarded the Goldwater Scholarship, ranking ASU alongside Duke and Princeton and ahead of Northwestern and UC-Berkeley. In the 2023 application cycle, 413 Goldwater Scholarships were awarded from a national pool of over 5,000 applicants. More than 400 colleges and universities submitted nominees.

Story submitted by the Lorraine W. Frank Office of National Scholarships Advisement

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Celebrating undergrad thesis research at Barrett, The Honors ... - ASU News Now

Biochemistry

NSCBMC Recruitment 2023: Check Posts, Qualification and How to … – StudyCafe

NSCBMC Recruitment 2023: Check Posts, Qualification and How to Apply

NSCBMC Recruitment 2023: Netaji Subhash Chandra Bose Medical College (NSCBMC) is inviting applications from eligible candidates for the posts of Research Scientist-II, Research Scientist-I, Lab Technician, Lab Assistant Cum Data Entry Operation (Grade-A) and Project Technician (IPEM Filed Worker) on a temporary and co-terminable with the project. As mentioned in the official notification of NSCBMC recruitment 2023, there are a total of 06 vacancies for the given posts. According to the official notification of NSCBMC recruitment 2023, the upper age limit is different for every post as given below in the article. As given in the official notification of NSCBMC recruitment 2023, the selected candidates will be given a monthly salary of upto Rs. 67000.

In accordance with the official notification of NSCBMC recruitment 2023, interested and eligible candidates can appear for the interview along with a duly filled-in application forms and relevant documents. The walk-in interview will be held on 11.04.23 at the Office of the Dean, NSCB, Medical College, Nagpur Road, Jabalpur (M.P) between 11 am to 1 pm.

NSCBMC is looking for qualified candidates for the posts of Research Scientist-II, Research Scientist-I, Lab Technician, Lab Assistant Cum Data Entry Operation (Grade-A) and Project Technician (IPEM Filed Worker) on a temporary and co-terminable with the project. As mentioned in the official notification of NSCBMC recruitment 2023, there are a total of 06 vacancies for the given posts.

According to the official notification of NSCBMC recruitment 2023, the upper age limit is given below.

For Research Scientist II- The upper age limit is 40 years.

For Research Scientist-I- The upper age limit is 35 years.

For Lab Technician- The upper age limit is 30 years.

For Lab Assistant Cum Data Entry Operation (Grade-A)- The upper age limit is 30 years.

For Project Technician (IPEM Filed Worker)- The upper age limit is 30 years.

Note 5 years age relaxation in case of ST/SC category candidates.

Candidates applying for NSCBMC recruitment 2023, must have the given below qualification.

For Research Scientist-II-

1- Postgraduate degree (MD/DNB) in Pathology/Biochemistry/Microbiology subject from a recognized university with 5 years R&D experience in Pathology Genetics or biomedical subjects OR MBBS Degree recognized by MCI from a recognized university with a minimum of 10 years R&D experience in Genetics or biomedical subjects OR Ph.D. degree in life sciences/ Biochemistry/ Microbiology/ Biotechnology in the relevant subject or equivalent from a recognized University with 5 years R&D experience in the related subject after Ph.D. OR First class Masters Degree in Biochemistry/ Microbiology/ Biotechnology /equivalent degree from a recognized University with 8 years R&D experience in Genetics or the biomedical subjects in recognized institute(s)

2- Thorough knowledge of Medical Statistics, Computer Applications/Data Management, data analysis and interpretation of results of statistical analysis

Desirable-Experience on Molecular biology techniques, immunohistochemistry and tumor pathology including histopathology and cytopathology. 2. Not less than 3 research publications (accepted) in indexed scientific journals 3. Supervised/ investigated scientific research projects as PI/ C-PI/ Co-L

For Lab Technician-

1- First class M.Sc. degree in life sciences / Biochemistry/ Microbiology! Biotechnology or related subject or equivalent degree from a recognized University with a minimum of 1 year of working experience in a clinical/ research laboratory and working knowledge of molecular biology equipment

2- Knowledge of Computer applications.

For Lab Assistant Cum Data Entry Operation (Grade-A)-

B.Sc degree from a recognized university with 1 years relevant experience as a Laboratory Assistant cum Data Entry Operator in clinical/research laboratory in a reputed institution.

Desirable-

1- Postgraduate Diploma in computer application.

2- Data evaluation experience.

To read the qualifications of all posts check the official notification

In accordance with the official notification of NSCBMC recruitment 2023, candidates will be given a monthly salary as given below-

For Research Scientist-II- The selected candidate will be given a monthly salary of Rs. 67000.

For Research Scientist-I- The selected candidate will be given a monthly salary of Rs. 56000.

For Lab Technician, Lab Assistant Cum Data Entry Operation (Grade-A) and Project Technician (IPEM Filed Worker)- The selected candidate will be given a monthly salary of Rs. 20000.

As per the official notification of NSCBMC recruitment 2023 notification, eligible candidates can appear for the interview along with duly filled-in application forms and relevant documents on 11.04.23 at the Office of the Dean, NSCB, Medical College, Nagpur Road, Jabalpur (M.P) between 11 am to 1 pm.

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Biochemistry

Taking a first bite of biochemistry – ASBMB Today

Amid the thousands of grad students, postdocs, early-career investigators and tenured professors streaming into the Seattle Convention Center for Discover BMB last month was 17-year-old Kimy Hernandez, a high school student.

Hernandez is a senior at Longmont High School in Colorado and like most of the more than 100 teenagers who attended the American Society for Biochemistry and Molecular Biology 2023 meeting a member of a Students Modeling a Research Topic, aka SMART, Team. Their mission: to present group research projects developed with their high school science teachers and, in many cases, with working scientists.

KELLY LUBKEMAN

Kimy Hernandez, 17, a senior at Longmont High School in Colorado and member of the SMART Teams program, shows off a 3D model of p53, a mammalian protein that suppresses tumors.

Inspired by SMART Teams meld of 3D modeling, analysis and research, Hernandez, who uses the pronoun they, is poised to become a first-generation college student. They plan to study molecular biology; their parents, both Mexican immigrants, were unable to study beyond high school.

SMART Team really served as a catalyst for my love of science and for pursuing it as a career, Hernandez said.

This years SMART participants hail from 21 schools in nine U.S. states and one Canadian province. As recently as 2019, before the COVID-19 pandemic, SMART Team and a sister program, Modeling a Protein Story, known as MAPS, sponsored 63 teams across the continent.

The only regret I have about SMART Team is not starting earlier, Hernandez said. SMART really provides you with a diverse group of people who teach you a lot about yourself.

Veteran attendees might experience ASBMB conferences as a collegial yearly break from their professional routine, but for high schoolers, the camaraderie can come as a revelation.

Tim Herman started the SMART Team program in 2001 and began bringing participants to the conference in 2004. The most powerful thing that happens is in the opening session, he said of the annual meeting. There will be SMART Teams in the audience, and they see people greeting each other. High school students can imagine themselves as future members of this community of science.

When they make their SMART Team presentations, students experience the realities of research life, said Luke De, a long-time teacher with SMART Teams at private schools in New Jersey and California. This includes giving talks about their studies and fielding sharp questions.

Kids have to get in front of M.D.s and Ph.D.s, De said. We harp on the idea that science is a conversation, but rarely do kids get to experience that conversation.

At the ASBMB meeting, that passionate exchange comes alive.

TIM HERMAN

SMART Team program founder Tim Herman, second from right, talks protein molecules with students from Governor's Academy of Byfield, Massachusetts in April 2016.

Weve always been focused on introducing students to the real world of science, including publishing and presentation, Herman said of SMART Teams. The conference gives these high school students the chance to stand alongside undergraduates and present their work.

A strength of any profession lies in its ability to recruit the next generation of practitioners, Herman pointed out. We have former SMART Team students who are now running research labs and interested in working with local SMART Teams, he said.

At Longmont High, Chris Chou, co-coordinator of the schools Medical and BioScience Academy, has been offering the SMART Team program for 11 years. She tells a story that illustrates the conferences impact.

During a SMART Team visit to the University of Colorado Boulder about six years ago, high schooler Maya Lippard Blau became smitten with X-ray crystallography for the study of proteins, Chou said. At the 2017 ASBMB annual meeting, Blau met Stephen White, a scientist doing this work at St. Jude Childrens Research Hospital in Memphis, Tennessee. The two swapped contact information, and the teenager went on to a 2018 summer research internship with her new mentor.

Instead of just reading about x-ray crystallography, she was doing it, Chou said, and that launched her interest in science.

Blau followed her passion through college and into an M.D./Ph.D. program in infectious diseases at the Medical College of Wisconsin. Because I was close to both the medical and the research side, I realized I couldnt picture my future career without both, she said.

In the short term, SMART Team means students having the opportunity to dive deeper into topics only touched on in courses, Chou said. They get to interact with professors, visit research laboratories.

Longmont students have taken a field trip to a Pfizer laboratory in Boulder, Colorado, to witness cancer drug research and visited the Biomolecular X-ray Crystallography Facility at the University of Colorado Boulder.

Kelly Lubkeman, co-coordinator with Chou of the academy at Longmont, echoes her colleagues enthusiasm. Her students normally would get the skills and basics in their classes but dont getthe exposure to what a research scientist really does on a daily basis, she said. SMART Team helps fill that gap.

Longmont students in the program now are studying and modeling the tumor suppressor protein p53. Mutations at several points in this macromolecule have been linked to human cancers and at least one is a potential drug target.

They call it the holy grail, Lubkeman said. If we could successfully target a drug for that mutation it will open the door for a lot of other cancer drug treatments.

Across the country at Mahtomedi High School in Minnesota, biology teacher Jim Lane has witnessed social and cognitive growth in his SMART Team students.

I see kids coming out of their shell but also developing discourse skills and collaboration, Lane said, adding that his students begin to forge the intellectual skills needed for research. They are constantly rethinking, iterating and reflecting on their learning. The collaborative atmosphere is what really pulls the team together.

SMART Team veteran Luke De believes the program can lead students to the heart of science as they gain confidence in their own curiosity.

Kids think the crazy ideas they have are frivolous, De said, but what they learn is that those crazy ideas are the things that make scientific research.

SEAN RYAN

Mark Arnholt, a high school teacher turned SMART Team coordinator, center, looks on as students at Cedarburg High School use 3D Molecular Designs Flow of Genetic Information Kit.

Abi Ferguson, 17, another Longmont senior, has been exploring the fine points of beta adrenergic receptors, which affect the function of smooth muscle and digestion. She has noticed the many medications, such as beta blockers, that interact with the protein she is studying.

While exploring her macromolecules, Ferguson got hooked on biology. She learned to find and decode crucial insights in research studies, gleaning more details about her proteins.

SMART Teams really pivoted me to science, Ferguson said. This is what I want to do.

Greta Wedel, also 17 and a senior at Longmont, said shes learned to read scientific journal articles and help her teammates write research abstracts. With these science-based skills, Wedel envisions a different career path but one that also demands high-level analysis and writing: the law.

No matter who you are, how you learn or what youre interested in, theres something valuable to find in SMART Teams for everyone, Wedel said.

Their classmate Hernandez has found it challenging to forge constructive relationships among SMART Team members. Yet, in their classmates differences, they have learned, lie the group's collective strength, as members take on specific tasks from model making to reading peer-reviewed research studies.

Theres a lot of people with lots of learning styles, Hernandez said. Everyones able to specialize.

SMART Teams are largely female, including young women of color a striking contrast to the historic underrepresentation of women and marginalized groups in the biological sciences.

KELLY LUBKEMAN

From left, Greta Wedel, Kimy Hernandez and Abi Ferguson, seniors at Longmont High School in Colorado, discuss their SMART Team project in late January, as they gear up to present at Discover BMB in Seattle.

What were doing is exposing more students to science research, because science is stereotypically done by white males, Chou said. Were trying to recruit a more diverse group of students who are traditionally underrepresented in science to pursue future careers in science.

The team aspect of the program plays to adolescent strengths and interests, as peer relationships gain importance in their social and academic development, noted SMART Team coordinator Mark Arnholt. You end up with students from very different social backgrounds working together and creating long-lasting friendships, he said.

Blau looks back on SMART Team as a foundation for the science she studies now. I ended up learning to read scientific papers, she said. It felt like I had a huge advantage in college and beyond.

For Abbey Kastner, 25, a doctoral student in neuroscience at the Medical University of South Carolina, the path to a science career started with SMART Team. She traces her first steps on that path to a talk on the program during freshman orientation at Hartford Union High School in her Wisconsin hometown. That introduction, Kastner said, made me realize theres jobs out there that involve research, and I can do them.

With the guidance of Arnholt, then a teacher at Hartford Union, Kastners SMART Team built a model of CYP17A1, a gene on chromosome 10 involved in drug metabolism and lipid synthesis.

We worked with researchers at Marquette University, Kastner said, which is something most high schoolers dont have the option to do.

MICHAEL OKAS

Abbey Kastner, a doctoral student in neuroscience at the Medical University of South Carolina, credits the SMART Team program getting her started on her journey toward a biological research career.

In 2016, Kastners senior year, her team project won a first-place award in a statewide spring competition at the Milwaukee School of Engineering. But the crucial takeaway from SMART Team was bigger than one prize.

The first thing was confidence, Kastner said.

Her burgeoning ambitions led to a summer internship at the Medical College of Wisconsin.

Kastner went on to study biochemistry and neuroscience at the University of WisconsinEau Claire. There she spent four years as a student researcher and two years as a lab manager.

Im grateful for all the mentorship Ive had because that is not extended to all students and certainly not to all female scientists, Kastner said.

Looking back, she said her first exposure to SMART Team was a catalyst for her science career: Its crazy that one conversation can change everything.

Blau and Kastner are case studies in the way SMART Team can help steer young people toward a research career.

SMART Teams, by offering high school students the chance to engage with basic scientific research, is inspiring the next generation of scientists, said Blau.

In addition to becoming a scientist, Kastner wants a role in the public conversation about scientific research. I feel like there is a gap between what the public knows and what scientists do in the lab, Kastner said. I want to be part of communicating between these audiences.

When 3D printing was a new invention, Tim Herman saw its potential as a tool for modeling macromolecules with crucial roles in living things and for strengthening secondary science education.

"I envisioned this 3D printing technology as the key to introducing high school students to the invisible molecular world, Herman said. Models give meaning to words.

Multiple research studies support the idea that 3D physical models help engage students and that students prefer them to other forms of learning.

While on the faculty of the Medical College of Wisconsin, Herman learned that the Milwaukee School of Engineering had a rapid prototyping center. He founded the Center for BioMolecular Modeling, or CBM, at the engineering school in 1998 and went on to launch 3D Molecular Designs, a family-owned company, the following year.

In the early 2000s at CBM, Herman led teachers in a new course, Genes, Schemes and Molecular Machines. They 3D-printed a ribosome, the cell structure that synthesizes polypeptides. The ribosome recently had been described for the first time by Thomas Steitz, a Yale University professor who would go on to win the 2009 Nobel Prize in chemistry with two colleagues.

The teachers were the ones who told us they wanted their students to have the same experience, Herman said.

And so Students Modeling a Research Topic, or SMART, Team was born in 2001 at the Milwaukee School of Engineering. In December 2021, the program moved as CBM merged into 3D Molecular Designs.

SMART Team garnered long-term support through the Science Education Partnership Award from the National Center for Research Resources at the National Institutes of Health. It also has received grants from the Howard Hughes Medical Institute. Each high school pays an annual $250 participation fee that helps fund technical support in the form of an experienced science educator and 3D model printing.

For high school students, the program begins with a training phase thats followed by a research phase. At the heart of the experience is the macromolecular model.

Mark Arnholt is a veteran science teacher and now coordinator for SMART Team. The second theyre holding that physical model is one of those aha moments, Arnholt said. They can finally understand why this protein is interacting the way it does.

Students start with the known story of a protein, model making, drafting an abstract, and reading both primary and secondary sources. Then they have the chance to devise their own research project.

Science is all about asking questions, and once youve identified those questions, you can start to chase them down, Arnholt said. A lot of the questions dont have answers, and those are the ones you want to pursue.

Luke De was a director of independent researchprojects at the Pingry School in Basking Ridge, New Jersey, in the early years of the program. SMART Teams did something genius: It paired kids with a researcher and forced them to tell a story, De said. All the stories were tangible; you were literally building a model.

And, in addition to being a learning tool, protein modeling helps high schoolers shine a light on the roots of human illnesses, Arnholt said. Slowly and steadily, students realize that every disease can be traced back to a protein that is misbehaving.

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Taking a first bite of biochemistry - ASBMB Today

Biochemistry

Postdoctoral Fellow in Plant Protein Biochemistry job with … – Times Higher Education

Job description

The University of Stavanger invites applicants fora two-year position as PostdoctoralFellow in Plant Protein Biochemistryat the Faculty of Science and Technology,Department of Chemistry, Bioscience and Environmental Engineering. The position is vacant for appointment as soon as possible.

The objective of the position is to strengthen research, and to give researchers/scholars holding a doctoral degree the opportunity for further qualification toward top academic positions.

The Postdoctoral Fellow will be affiliated with the project The machinery positioning chlorophyll in Cytochrome b6f .

The focus of the work is on the isolation of membrane protein complexes, the regulation of protein subunit translation in-vivo and in-vitro, and the assembly of the protein subunits into an enzymatically active complex.

The position is funded by The Reseach Council of Norway.

The qualifyingproject will be carried out at the University of Stavanger.It is assumed that the appointee will work full time on the project and that she/he will participate in the academic community.

Yourapplication must contain a competence assessment. Please outline your current contributions in the experimental sciences, and how working on the project will add to your competence.

In the project, proteins binding to ribosomes, nascent polypeptide chains, and chlorophyll are investigated during the assembly of Cytochrome b6f. The project description and a detailed experimental plan are drawn up in consultation with the project leader during the first three months of the employment period. It is a prerequisite that you complete the project during the employment period.

You must have a Ph.D. with a specialisation relevant for the project. The Ph.D.thesis must have beensubmitted for evaluation within the application deadline for the position and approved before accession.

In addition you should have:

You must have a good command of both oral and written English.

In the assessment the following criteria will be emphasized:

University of Stavanger values independence, involvementand innovation. Diversity is respected and considered a resource in our work and learning environment. Universal design characterises physical and digital learning environments, and we strive to provide reasonable adjustments for employees with disabilities.

You are encouraged to apply regardless of gender, disability or cultural background.

More information on the position can be obtained from Professor Lutz Eichacker, tel: +47 51 83 18 96, e-mail:lutz.eichacker@uis.noor Head of Department Ingunn W. Jolma, e-mail:ingunn.w.jolma@uis.no.

Information about the appointment procedure can be obtained from HR-advisor Rosa Andrade, tel: +47 51 83 11 91,e-mail:rekruttering@uis.no.

To apply for this position please follow the link "Apply for this job". Yourapplication letter, relevant education and work experience as well as language skills must be registered here. In the application letter, you must state your research interestsand motivation for the position.

The following documents must be uploaded as attachments to your application:

Applications are evaluated based on the information available in Jobbnorge on the application deadline. You should ensure that your application shows clearly how your skills and experience meet the criteria which are set out above.

The documentation must be available in either a Scandinavian language or in English. If the total size of the attachments exceeds 30 MB, they must be compressed before upload.

Please note that information on applicants may be published even if the applicant has requested not to be included in the official list of applicants - seeSection 25 of the Freedom of Information Act.If your request is not granted, you will be notified.

UiS only considers applications and attachments registered in Jobbnorge.

The engagement is to be made in accordance with the regulations in force concerning State Employees and Civil Servants, and the acts relating to Control of the Export of Strategic Goods, Services and Technology. If your application is considered to be in conflict with the criteria in the latter legislation, it willbe rejected without further assessment.

Employment as Postdoctoral Fellowis regulated in"Regulations concerning terms and conditions of employment for the posts of post-doctoral research fellow and research fellow, research assistant and resident".

Your qualificationsfor the position, based on documentation registered in Jobbnorge, will be assessed by an internalexpert committee.Based on the committee's statement, relevant applicants will be invited to an interview before any recommendations are made. References will also be obtained for relevant candidates.More about the hiring process onour website.

UiS has an Acquisition of Rights Agreement for the purpose of securing rights to intellectual property created by its employees, includingresearch results.

It is a prerequisite that you havea residence which enables you to be present at/available to the academic community during ordinary working hours.

The position has been announced in both Norwegian and English. In the case of differences of meaning between the texts, the English text takes precedence.

The University of Stavanger (UiS) has about 12,000 students and 2,200 employees.The university has high ambitions.We strive to have an innovative and international profile, and be a driving force in knowledge development and in the process of societal change.Our common direction is driven by considerationfor green and sustainable change and equitable social development, through new ways of managing natural resources and facilitating better cities and local communities. Energy, health and welfare, learning for life are our focus areas.

In constant collaboration and dialogue with our surroundings, regionally, nationally and internationally, we enjoy an open andcreative climate for education, research, innovation, dissemination and museum activities. Academic life at the University of Stavanger is organised into six facultiescomprising various departments/schools and National Research Centres, as well as the Museum of Archaeology.We are a member of the European Consortium of Innovative Universities. The university is located in the most attractive region in the country with more than 300,000 inhabitants. The Stavanger region has a dynamic labour market and exciting cultural and leisure activities.

Together with our staff and studentswe will challenge the well-known and explore the unknown.

The Faculty of Science and Technologyoffers study programs at bachelor, master and doctoral level. The faculty has established close cooperation on research withNORCE (Norwegian Research Centre AS)and the regional industry. A number of master's and doctoral theses are made in collaboration with the industry. The faculty has established research collaborations with universities in the US and Europe, and has developed several academic environments that are at the forefront internationally.The faculty has about 2,800 students and approximately 500 employees at the Department of Electrical Engineering and Computer Science, Department of Structural Engineering and Materials Science, Department of Mathematics and Physics, Department of Energy and Petroleum Engineering,Department of Energy Resourcesand the Department ofSafety, Economicsand Planning.

The Department of Chemistry, Bioscience and Environmental Technologyoffers study programs at all levels within the areas Biological Chemistry, Chemistry and Environment. Thedepartment is responsible for basic tuition in chemistry at the faculty. There are currently about 60employees including doctoral and postdoctoral fellows, and 230students at the department.

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Postdoctoral Fellow in Plant Protein Biochemistry job with ... - Times Higher Education

Biochemistry

Experiential learning, access to opportunities highlighted at Board of … – Virginia Tech Daily

More than two-thirds of Virginia Tech students complete internships during their college careers, significantly increasing the likelihood that theyll land successfully in a job after college or pursue graduate education. With the implementation of the Bridge Experience Program as the universitys Quality Enhancement Plan in 2020, Virginia Tech has continued to make work-based experiential learning, which include internships and similar co-op experiences, central to its hands-on, minds-on approach to undergraduate education.

We want to make sure internships and other experiential learning opportunities are happening for all our students and that it helps them to be successful after graduation, Kim Filer, associate vice provost for teaching and learning, told the Academic, Research and Student Affairs Committee at a panel discussion Monday highlighting issues of access to experiential learning.

During the panel discussion and board meetings, where the Board of Visitors examined access and affordability across the university, Filer indicated that barriers to experiential learning typically results from one of the four Cs cost, communication, curricula, and capacity.

Panelist Donna Westfall-Rudd, associate professor in the Department of Agricultural, Leadership, and Community Education, part of the College of Agriculture and Life Sciences, agreed that cost is a barrier for many of her students from rural communities, adding, Theyre often limited in options they have for paid experiences. Alumni from the College of Agriculture and Life Sciences reported that financial assistance would have helped them pursue more experiential learning opportunities while at Virginia Tech.

According to research from Virginia Techs Center for Excellence in Teaching and Learning (CETL), in-state students from rural areas are the least likely to participate in a paid internship, deterred by housing and relocation costs or the summer tuition required to get curricular credit for an internship.

To overcome barriers related to communication and curricula and deliver on the universitys commitment to engage students in active learning outside the classroom, the Bridge Experience Program works to integrate experiential learning into departmental curricula so that students can identify desirable opportunities early on through guided exploration in class. Research indicates that students thrive when they can apply classroom learning in professional contexts.

Ann Brown, assistant professor of biochemistry in the College of Agriculture and Life Sciences and a participant in the Bridge Experience Program, shared with board members how her department looked really deeply at where majors from biochemistry are going from Virginia Tech and around the country, then created ways for them to explore internship and research opportunities, initially in the First-Year Experience (FYE) course and continuing in a second-semester biochemistry FYE course, which includes a course-embedded undergraduate research experience.

To help students effectively craft their bridge experience plan, an optional sophomore-year career prep course brings in guest speakers from a wide variety of biochemistry career paths. Some students need more guidance about what you can do with a degree in biochemistry, said Brown. The experience is also important in helping students see that a certain path sometimes may not be best for them or fit their career interests. This is an important part of the experiential learning process as well.

Though her years at Virginia Tech have been peppered with bridge experiences like internships, study abroad, and undergraduate research, panel member Madeline Eberhardt, a senior in English, part of the College of Liberal Arts and Human Sciences, with a pre-education option, said students in smaller majors like hers need additional support to find internships that might guide a career path.

Currently, Eberhardt interns with CETL, one of several internships and undergraduate research assistantships she's completed. Yet shes mindful of peers and alumni who lacked access to such work-based experiential learning. We need to provide all students with a path forward, she said.

Of the four Cs that inhibit experiential learning, capacity may be the most pervasive and is a support area of emphasis for Virginia Tech. We need to develop more opportunities, and the university is committed to providing those for students, Filer said. Regardless of your discipline or major, we are working to create the capacity to give students these important and engaged learning experiences.

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Experiential learning, access to opportunities highlighted at Board of ... - Virginia Tech Daily

Biochemistry

Global Hemp Group Announces Appointment of Dr. Herbert Fritsche, Former Professor of Laboratory Medicine and Chief of the Clinical Chemistry Section…

Vancouver, British Columbia--(Newsfile Corp. - March 22, 2023) - GLOBAL HEMP GROUP INC.(CSE: GHG) (OTC Pink: GBHPF)(FSE: GHG) ("GHG" or the "Company")is pleased to announce the appointment of Dr. Herbert Fritsche to the Company's Advisory Board as its Chief Scientific Advisor. Dr. Fritsche is a world-renowned Clinical Chemist and former Professor of Laboratory Medicine and Chief of the Clinical Chemistry Section at the University of Texas MD Anderson Cancer Center for 41 years.

Dr. Fritsche served as an invited consultant/advisor to the Food and Drug Administration, the National Cancer Institute, the Laboratory Practice Guidelines Committee for the National Academy of Clinical Biochemistry, the Editorial Board of six international scientific journals, and as a consultant to many major international diagnostic companies. Previously, he served on the Expert Panel for developing Tumor Marker Practice Guidelines for the American Society of Clinical Oncology (ASCO) from its inception until his retirement from MD Anderson Cancer Center.

His awards include the Johnson and Johnson Award for Outstanding Research and Contributions to Clinical Biochemistry from the National Academy of Clinical Biochemistry, the Abbott-ISOBM Award for Outstanding Research in Oncology, the Morton K. Schwartz Award for Outstanding Achievements in the field of Cancer Diagnostics from the American Association for Clinical Chemistry ("AACC"), the Carl Jolliff Award for Lifetime Achievements in Immunology and Immunodiagnostics from the Immunology Division of the AACC, the Morton K. Schwartz Award for significant contributions to the development of cancer diagnostics from the New York Metro Division of the AACC, the Outstanding Clinical Chemist Award by the Texas Section of the AACC, the National Award for Contributions in Education by the AACC, the Dean's Excellence Award from the University of Texas Graduate School of Biomedical Science, and the Distinguished Scientist Award from the Clinical Ligand Assay Society ("CLAS").

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Dr. Fritsche has served as President of the CLAS and various national committees for both the CLAS and AACC. He is a Fellow of the National Academy of Clinical Biochemistry.

He has published over 200 peer-reviewed scientific papers, invited articles and book chapters, and participated in the validation and FDA clearance process for many commercial serum cancer markers currently in use in the United States. Dr. Fritsche holds three patents and two patents pending.

Dr. Fritsche has lectured extensively for many years at international and national meetings of medical and professional societies, and he is recognized internationally as an expert in the field of clinical chemistry, cancer diagnostics and laboratory medicine.

Dr Fritsche stated, "I am pleased to continue working with Stephen Barnhill, Jr. and I look forward to now working with him to expand GHG's efforts to sublicense the exclusively licensed unique intellectual property from Apollon Formularies, plc on the natural biologic pharmaceutical formulations for cancer, inflammatory diseases and chronic pain, thereby, increasing accessibility of these products to help patients around the world where they are legal."

"Dr. Fritsche is a highly respected international authority in clinical chemistry and one of the world's leading experts on cancer biomarkers, whom I have had the honor of working with for more than 10 years. We are extremely pleased that he has agreed to join GHG's Advisory Board as our Chief Scientific Advisor ("CSA")," stated Stephen D. Barnhill, Jr. CEO of Global Hemp Group, "As GHG's CSA, Dr. Fritsche will be leading all scientific aspects of GHG's global licensing program for the intellectual property portfolio GHG recently licensed from Apollon."

About Global Hemp Group Inc.

Global Hemp Group Inc. (CSE: GHG) (OTC Pink: GBHPF) (FSE: GHG) is focused on executing a multi-phased strategy to become a leader in the industrial hemp industry. To further support and innovate, GHG has established a R&D Division to actively pursue the development of Intellectual Property that can be patented for implementation at its projects and beyond. The Division is led by Prof. Vctor M. Castao, Ph.D., whose career has focused in the areas of applied science and technology. The R&D team will initially focus on development of Environmentally Friendly Construction Materials, Nano Fertilizers and Enhanced Extraction from Hemp.

Cautionary Note Regarding Forward-Looking Statements

Certain information set forth in this news release may contain forward-looking statements that involve substantial known and unknown risks and uncertainties. These forward-looking statements are subject to numerous risks and uncertainties, certain of which are beyond the control of Global Hemp Group Inc., including, but not limited to, the impact of general economic conditions, industry conditions, volatility of commodity prices, currency fluctuations, dependence upon regulatory approvals, the availability of future financing and exploration risk, and the legality of cannabis and hemp. Readers are cautioned that the assumptions used in the preparation of such information, although considered reasonable at the time of Page 2 of 2 preparation, may prove to be imprecise and, as such, undue reliance should not be placed on forward-looking statements. Except as required by law, Global Hemp Group Inc. disclaims any intention and assumes no obligation to update or revise any forward-looking statements to reflect actual results, whether as a result of new information, future events, changes in assumptions, changes in factors affecting such forward-looking statements or otherwise.

The CSE has not reviewed and does not accept responsibility for the adequacy or accuracy of this release.

For Further Information Contact Global Hemp Group

Investor Relations

Tel: 778-726-2900 info@globalhempgroup.com

http://www.globalhempgroup.com

Subscribe to the GHG YouTube Channel: https://www.youtube.com/channel/UCtjFn9dOyHMxJee-_37MTrw

Like us on Facebook: https://www.facebook.com/globalhempgrp

Follow us on Instagram: https://www.instagram.com/hemp_global/

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Connect with us on LinkedIn: https://www.linkedin.com/company/18596421

To view the source version of this press release, please visit https://www.newsfilecorp.com/release/159400

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Global Hemp Group Announces Appointment of Dr. Herbert Fritsche, Former Professor of Laboratory Medicine and Chief of the Clinical Chemistry Section...

Biochemistry

Protein Capture Innovation from WL Gore & Associates – BioProcess Insider

This interview features: William Barrett, PhD, Product Specialist, WL Gore & Associates.

William Barrett, PhD is a product specialist with WL Gore & Associates. He has over 20 years combined experience in biotechnology, chromatography, and the medical device industries. Most recently at WL Gore, Bills focused on affinity purification chromatography. Previously, Bill worked at Agilent on affinity depletion devices used in biomarker discovery and proteomics. He received a PhD in biochemistry from the University of Illinois and completed his fellowship in the Laboratory of Biochemistry at the National Heath, Lung, and Blood Institute at the NIH.

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Protein Capture Innovation from WL Gore & Associates - BioProcess Insider

Biochemistry

Exploring marine science at the cellular level – ASBMB Today

How do you end up studying how stingray venom affects cancer cells?

For Karlie Tischendorf, it all began when a high school English teacher assigned each student to learn about and present on any topic of their choice. Tischendorf saw this as a blank check to satisfy her curiosity about coral bleaching. After a deep dive into this process, she knew she had to get involved in marine biology.

Brooke Leuking

Now a senior at Purdue University, Tischendorf started her undergraduate career as an aquatic science major, but after a few classes, she was unsatisfied she wanted to understand marine life on the microscopic level. She shared her discontent with her mentor, and after reviewing the possible options and receiving additional guidance from her adviser, Tischendorf changed her major to biochemistry with a minor in aquatic science. She also has a second minor in Spanish.

Atlantic stingrayin an aquarium.

In 2022, Tischendorf spent 10 weeks as an intern at the Mote Marine Laboratory and Aquarium in Sarasota, Florida. Designed in partnership with the National Science Foundation, the Research Experiences for Undergraduates program gives undergraduates a concise and hands-on experience in real-world marine research. She worked with long-time Mote Labs researchers Cathy Walsh and Carl Luer on extracting venom from stingrays. Its a challenging process; in other organisms, venom is stored in a gland, but stingray venom is stored in tissue cells in the spine.

To learn about the therapeutic potential of compounds in the venom, Tischendorf used a variety of assays to determine how it would affect cells isolated from a mouse with fibrosarcoma, a malignant cancer. While this project still has a ways to go, Walsh said, The initial results are exciting and gave us the interest to want to continue going further.

This is one of five research projects Tischendorf has worked on as an undergraduate. Her advice to students interested in science is to find habits that work for them individually, be patient with themselves and beware of making unhealthy comparisons. She also advises, Say yes to opportunities as they come up because you really dont know where its going to lead you.

When her adviser encouraged Tischendorf to apply to be outreach co-chair in the biochemistry club even though shed never attended a meeting she followed her own advice. As a result, she met more peers and built meaningful relationships. To this day, she says it was one of the best things that could have ever happened.

Similarly, she said changing her major to biochemistry was a shot in the dark. But that shot led her to a plethora of experiences, each preparing her for her next opportunity. After her graduation in May, Tischendorf said shell take a gap year before applying to Ph.D. programs that allow her to delve deeper into marine ecotoxicology. Shes also been working toward her scuba certification so she can spend time diving around St. Kitts and Nevis as well as Turks and Caicos.

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Exploring marine science at the cellular level - ASBMB Today

Biochemistry

Photosynthesis ‘hack’ could lead to new ways of generating renewable energy – Phys.org

Researchers have hacked the earliest stages of photosynthesis, the natural machine that powers the vast majority of life on Earth, and discovered new ways to extract energy from the process, a finding that could lead to new ways of generating clean fuel and renewable energy. Credit: Robin Horton

Researchers have 'hacked' the earliest stages of photosynthesis, the natural machine that powers the vast majority of life on Earth, and discovered new ways to extract energy from the process, a finding that could lead to new ways of generating clean fuel and renewable energy.

An international team of physicists, chemists and biologists, led by the University of Cambridge, was able to study photosynthesisthe process by which plants, algae and some bacteria convert sunlight into energyin live cells at an ultrafast timescale: a millionth of a millionth of a second.

Despite the fact that it is one of the most well-known and well-studied processes on Earth, the researchers found that photosynthesis still has secrets to tell. Using ultrafast spectroscopic techniques to study the movement of energy, the researchers found the chemicals that can extract electrons from the molecular structures responsible for photosynthesis do so at the initial stages, rather than much later, as was previously thought. This 'rewiring' of photosynthesis could improve ways in which it deals with excess energy, and create new and more efficient ways of using its power. The results are reported in the journal Nature.

"We didn't know as much about photosynthesis as we thought we did, and the new electron transfer pathway we found here is completely surprising," said Dr. Jenny Zhang from Cambridge's Yusuf Hamied Department of Chemistry, who coordinated the research. Despite the fact that it is one of the most well-known and well-studied processes on Earth, researchers from the University of Cambridge have found that photosynthesis still has secrets to tell. Using ultrafast spectroscopic techniques to study the movement of energy, the researchers found the chemicals that can extract electrons from the molecular structures responsible for photosynthesis do so at the initial stages, rather than much later, as was previously thought. This rewiring of photosynthesis could improve ways in which it deals with excess energy, and create new and more efficient ways of using its power. Credit: Mairi Eyres

While photosynthesis is a natural process, scientists have also been studying how it could be used as to help address the climate crisis, by mimicking photosynthetic processes to generate clean fuels from sunlight and water, for example.

Zhang and her colleagues were originally trying to understand why a ring-shaped molecule called a quinone is able to 'steal' electrons from photosynthesis. Quinones are common in nature, and they can accept and give away electrons easily. The researchers used a technique called ultrafast transient absorption spectroscopy to study how the quinones behave in photosynthetic cyanobacteria.

"No one had properly studied how this molecule interplays with photosynthetic machineries at such an early point of photosynthesis: we thought we were just using a new technique to confirm what we already knew," said Zhang. "Instead, we found a whole new pathway, and opened the black box of photosynthesis a bit further."

Using ultrafast spectroscopy to watch the electrons, the researchers found that the protein scaffold where the initial chemical reactions of photosynthesis take place is 'leaky', allowing electrons to escape. This leakiness could help plants protect themselves from damage from bright or rapidly changing light.

"The physics of photosynthesis is seriously impressive," said co-first author Tomi Baikie, from Cambridge's Cavendish Laboratory "Normally, we work on highly ordered materials, but observing charge transport through cells opens up remarkable opportunities for new discoveries on how nature operates."

"Since the electrons from photosynthesis are dispersed through the whole system, that means we can access them," said co-first author Dr. Laura Wey, who did the work in the Department of Biochemistry, and is now based at the University of Turku, Finland. "The fact that we didn't know this pathway existed is exciting, because we could be able to harness it to extract more energy for renewables." Researchers have hacked the earliest stages of photosynthesis, the natural machine that powers the vast majority of life on Earth, and discovered new ways to extract energy from the process, a finding that could lead to new ways of generating clean fuel and renewable energy. Credit: Tomi Baikie

The researchers say that being able to extract charges at an earlier point in the process of photosynthesis, could make the process more efficient when manipulating photosynthetic pathways to generate clean fuels from the Sun. In addition, the ability to regulate photosynthesis could mean that crops could be made more able to tolerate intense sunlight.

"Many scientists have tried to extract electrons from an earlier point in photosynthesis, but said it wasn't possible because the energy is so buried in the protein scaffold," said Zhang. "The fact that we can steal them at an earlier process is mind-blowing. At first, we thought we'd made a mistake: it took a while for us to convince ourselves that we'd done it."

Key to the discovery was the use of ultrafast spectroscopy, which allowed the researchers to follow the flow of energy in the living photosynthetic cells on a femtosecond scalea thousandth of a trillionth of a second.

"The use of these ultrafast methods has allowed us to understand more about the early events in photosynthesis, on which life on Earth depends," said co-author Professor Christopher Howe from the Department of Biochemistry.

More information: Jenny Zhang, Photosynthesis re-wired on the pico-second timescale, Nature (2023). DOI: 10.1038/s41586-023-05763-9. http://www.nature.com/articles/s41586-023-05763-9

Journal information: Nature

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Photosynthesis 'hack' could lead to new ways of generating renewable energy - Phys.org