UNIVERSITY PARK, Pa. Sarah Ades, associate professor of biochemistry and molecular biology at Penn State, has been named a 2017 Penn State Teaching Fellow, the Penn State Alumni Association Award for Excellence in Teaching. The award was established by the Alumni Association, in conjunction with the undergraduate and graduate student governing bodies, in 1988 to honor distinguished teaching and to encourage teaching excellence.

Ades was recognized for her unique inquiry-based approach to teaching. She restructured her classes to reflect a scientific community where students work collaboratively and share results to address scientific problems.

Science is best learned by engaging in the scientific process, whether that is analyzing problems in the classroom or designing experiments in the lab, said Ades. My role as a teacher is similar to that of a coach. I guide students in learning new skills and concepts, design materials to help them practice these skills, and challenge them to apply these skills to new situations.

Research in the Ades laboratory focuses on understanding how information about changes in the environment, such as the presence of antibiotics, is transmitted from the outer cell compartment of a bacterial cell to components within the cell so that the bacteria can respond to these changes. She has developed methods to identify small molecules that can interrupt the cellular-signaling pathways that transmit this information. These molecules will be important compounds for the development of new kinds of antibiotics and can be used as tools for basic research.

In 2015, Ades was awarded the C.I. Noll Award for Excellence in Teaching by the Eberly College of Science Alumni Society for her collaboration with Kenneth Keiler, professor of biochemistry and molecular biology at Penn State. They transformed two undergraduate courses that encourage students to ask scientific questions and to design and perform experiments to answer these questions. A paper about this transformation was published in the journal PLoS Biology in 2017.

In 2013, Ades was a winner of the GlaxoSmithKline PLC (GSK) Discovery Fast Track Challenge, a competition designed to accelerate the translation of academic research into novel medical therapies. Her research has been published in journals such as Molecular Microbiology, the Journal of Bacteriology, and PLoS One.

Ades earned a doctoral degree in biology at the Massachusetts Institute of Technology in 1995 and a bachelor's degree in molecular biophysics and biochemistry at Yale University in 1988. Prior to joining the Penn State faculty in June of 2002, she was a postdoctoral fellow at the University of California at San Francisco from 1997 to 2002 and at the Institut de Biologie Molecularie et Cellulaire in Strasbourg, France, from 1995 to 1997.

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Sarah Ades named 2017 Penn State Teaching Fellow - Penn State News

UPDATE 1-U.S. top court grapples over making copycat biologics available sooner

WASHINGTON, April 26 U.S. Supreme Court justices on Wednesday struggled over whether to speed up the time it takes to bring to the market copycat versions of biologic drugs, expensive medicines that can generate billions of dollars in sales for drug makers.

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BRIEF-Beijing Leadman Biochemistry to pay cash div 0.1 yuan per 10 shares for FY 2016 - Reuters

UTSW researchers helped solve this structure showing how two Ebola proteins interact, VP35 (black) and NP (rainbow). Credit: UT Southwestern Medical Center

After a decade of work, the Center for Structural Genomics of Infectious Diseases (CSGID) a consortium of 10 scientific institutions in the U.S., Europe, and Canada announced that it has determined the 3-D atomic structures of more than 1,000 proteins.

Determining these structures is an important step in identifying and understanding where a pathogen might be vulnerable to assault by drugs or vaccines. Such vulnerabilities are frequently found at the points where molecules bind to one another, said Dr. Zbyszek Otwinowski, Professor of Biophysics and Biochemistry, who leads the UT Southwestern group participating in the project. Dr. Dominika Borek, Assistant Professor of Biophysics and Biochemistry, who works in Dr. Otwinowskis laboratory, contributed crucial expertise for the successful completion of these studies.

To make a 3-D structure, a protein must be cloned, expressed, and crystallized, and then X-ray diffraction data are collected at the Advanced Photon Source at Argonne National Laboratory. These data define the location of each of the hundreds or even thousands of atoms to generate 3-D models of the structures that can be analyzed with graphics software. Each institution in the Center has an area of expertise it contributes to the project, working in parallel on many requests at once.

The UT Southwestern team manages the salvage pathway, meaning scientists design custom methods for determining structures of molecules that resist standard approaches and for which the high potential for drug or vaccine development justifies applying advanced efforts.

Structures solved with help from the UT Southwestern team include proteins involved in the replication of the Ebola virus a pathogen notorious for its ability to evade the bodys immune system. Their X-ray crystallography work formed the basis for preclinical studies currently underway in university and industry laboratories.

When other scientists run into trouble determining crystal structures, Drs. Otwinowski and Borek are among the top people in the world who can develop these advanced approaches because they understand the theory so deeply and they have created such powerful methods to deal with difficult problems, said Dr. Michael Rosen, Chair of Biophysics at UT Southwestern and a Howard Hughes Medical Institute Investigator. Dr. Rosen has secondary appointments as a Professor of Biochemistry and in the Cecil H. and Ida Green Comprehensive Center for Molecular, Computational, and Systems Biology. Dr. Rosen also holds the Mar Nell and F. Andrew Bell Distinguished Chair in Biochemistry.

UT Southwesterns contribution to the Ebola project began when a scientist at the Washington University School of Medicine requested the consortiums help in structural studies of the Ebola protein VP35. UTSW researchers conducted detailed structural studies of a VP35 protein fragment that interacts with the Ebola nuclear protein (NP) to form a complex that protects Ebolas genetic material from digestion by the hosts enzymes.

The structure revealing the interactions between the VP35 fragment and the NP protein provided the first glimpse into the protein complexs role in viral replication. That work, part of a multicenter study to better understand the complexs function, was reported as a Cell Reports cover story in 2015.

This 3-D structure is among the 1,000 now deposited by the consortium into the World-Wide Protein Data Bank, an archive supported by the National Institutes of Health that is freely available to the scientific community. The CSGIDs breakthrough research is funded by two five-year contracts from the National Institute of Allergy and Infectious Diseases, with a total budget of $57.7 million.

This article has been republished frommaterialsprovided by UT Southwestern Medical Center. Note: material may have been edited for length and content. For further information, please contact the cited source.

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Fighting Infectious Diseases Using 3D Weapons - Technology Networks

Dr. Gerry Wright, Director of the renowned Michael G. DeGroot Institute for Infectious Disease Research at McMaster University in Ontario, will present Antibiotic Resistance: What is it, where does it come from and what can we do about it? on Thursday, April 27 at 7 p.m. in the Boliou Hall Auditorium at Carleton College.

Wright is a professor in the Department of Biochemistry and Biomedical Sciences, and an associate member in the Departments of Chemistry and Chemical Biology and of Pathology and Molecular Medicine at McMaster University. Founded in 2007, the DeGroote Institute for Infectious Disease Research (IIDR) is a world-leading center for transdisciplinary infectious disease research, focused on life-altering work in the fields of virology, immunology, bacterial pathogenesis, and population biology and epidemiology. More at http://www.mcmasteriidr.ca.

Dr. Wright received his BSc in Biochemistry (1986) and his PhD in Chemistry (1990) from the University of Waterloo working in the area of antifungal drugs, later completing postdoctoral research at Harvard Medical School where he worked on the molecular mechanism of resistance to the antibiotic vancomycin in enterococci. He joined the Department of Biochemistry at McMaster in 1993.

Wright was elected as a Fellow of the Royal Society of Canada (2012) and a fellow of the American Academy of Microbiology (2013). He is the recipient of the Canadian Institutes of Health Research Scientist (2000-2005), Medical Research Council of Canada Scholar (1995-2000), Killam Research Fellowship (2011-1012), R.G.E. Murray Award for Career Achievement of the Canadian Society of Microbiologists (2013), NRC Research Press Senior Investigator Award from the Canadian Society for Molecular Biosciences (2016), Premiers Research Excellence (1999) and the Polanyi Prize (1993). In 2016 he was named a McMaster Distinguished University Professor.

Wright has served on grant panel advisory boards and chaired grant panels for a number of funding agencies in Canada, the US, and Europe and consults widely for the pharmaceutical and biotech sectors.

He is the author of over 240 manuscripts and is a member of the editorial boards of several peer-reviewed journals including mBio, Antimicrobial Agents Chemotherapy, Cell Chemistry and Biology and the Journal of Antibiotics. He is an Associated Editor of ACS Infectious Diseases and Editor of Annals of the New York Academy of Sciences, Antimicrobial Therapeutics Reviews.More at http://www.thewrightlab.com.

This event is sponsored by the Carleton College Department of Chemistry, with support from The Frank G. and Jean M. Chesley Lectureship Fund. For more information, including disability accommodations, call (507) 222-5769. Boliou Hall is accessible via Highway 19 in Northfield.

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Chesley lecture looks at Antibiotic Resistance: What is it, where does it come from and what can we do about it? - Carleton College News

Some of the most water-efficient plants do an unexpected thing at night. They take up carbon dioxide at night instead of during the warmer daytime, which improves efficiency of water use and adaption to semi-arid and arid climates.

John Cushman is one of the world's leading researchers on the molecular genetics of this specialized type of photosynthesis, which is known as crassulacean acid metabolism or CAM photosynthesis. His research and plant molecular-genetics program at the University of Nevada, Reno are nationally and internationally recognized, and have made important contributions to understanding and developing more water-efficient plants. In recognition of this, the foundation professor of biochemistry and molecular biology within the College of Agriculture, Biotechnology and Natural Resources will receive the 2017 Nevada Regents' Researcher Award.

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"CAM used to be thought of as a curiosity: a weird, esoteric thing that a few desert plants do," Cushman said. "It was a biological curiosity, but wouldn't you want to have this biological application apply to more plants to improve water-use efficiency?

"There was no inkling early on that this would have the impact it is having. Now, people are realizing the importance of this," he said.

After completing his master's and doctoral degrees in microbiology at Rutgers University, Cushman was awarded a post-doctoral fellowship in plant biology by the National Science Foundation. Through that fellowship, 30 years ago he began working at the University of Arizona, Tucson on what would become the focus of his career - plant stress and CAM plants such as agave and cactus.

Cushman has served as principal or co-principal investigator on research projects totaling more than $28 million in grant funding, has published more than 150 peer-reviewed papers and non-peer reviewed book chapters and lay publications. He currently serves as principal investigator on a multi-institutional, $14.3 million grant-funded project supported by the U.S. Department of Energy to explore the genetic mechanisms of CAM. The five-year project, now in its final year, is innovating understanding of drought tolerance in desert-adapted plants and application of this knowledge to biofuel crops. The project includes a $7.6 million grant award to the University of Nevada, Reno, with sub-awards to researchers at the Oak Ridge National Laboratory, the University of Newcastle, and the University of Liverpool.

Through this and other grant-supported projects, the Cushman laboratory team is sequencing the genomes of several CAM plants and applying genome-editing technology to further improve their water-use efficiency. In one discovery through the DOE project, the leaf anatomy of the plant was changed, which increased its drought and salt tolerance.

In their nomination of Cushman for the award, Department of Biochemistry and Molecular Biology Chair Claus Tittiger and Professor Gary Blomquist note the increasing relevance of Cushman's research program for sustainable agriculture and water use, especially in the face of global climate change.

"Currently, approximately 40 percent of the world's land area is considered arid, semi-arid or dry sub-humid, with precipitation amounts that are inadequate for most conventional agriculturally important C3 or C4 (photosynthesis) crops," they wrote. "Prolonged drought and over-reliance on groundwater for crop irrigation has led to the depletion of aquifers in the US and across the globe. The development of more drought tolerant or water-use efficient crops should positively impact the future of agriculture in the state while promoting the wise use of limited water resources in Nevada and in arid states throughout the western U.S."

For the past dozen years, Cushman has served as director of the University's biochemistry graduate program, which is an interdisciplinary collaboration in the Molecular Biosciences among the Cell and Molecular Biology Program and the Cellular and Molecular Pharmacology and Physiology Program within the College of Agriculture, Biotechnology and Natural Resources, the College of Science and the School of Medicine. The directorship exemplifies two aspects of higher education that Cushman values: the overlap between research and education and the increasing importance of multidisciplinary collaboration.

Cushman has witnessed and appreciates the evolution of research from single-investigator programs to larger, comprehensive programs.

"Large genome sequencing and bioinformatics projects need large teams," he said. "The technology is such that you can't be an expert in all of the research methodologies involved. We need and rely upon good collaborators."

As for his commitment to education and students, Tittiger and Blomquist wrote, "Dr. Cushman has made significant contributions to graduate education. He has not only mentored an impressive number of doctoral students and postdoctoral scholars over his career, many of whom have gone on to realize successful careers as independent scientists, but also he has been integral to maintaining the high quality of the biochemistry graduate program throughout his tenure as Graduate Program Director."

Cushman remains excited about the future and sees the field of synthetic biology as the next frontier. He also is enthusiastic about contributing to the University's expanding research and teaching presence in dryland, sustainable agriculture.

"With Nevada being the driest state, we'd like to become known for our growing expertise," Cushman said.

The Nevada Regents' Research Award is presented annually to one faculty member across the institutions of the Nevada System of Higher Education. An NSHE selection committee reviews nominations from the institutions and recommends an honoree to the Nevada Board of Regents' Academic and Student Affairs Committee for approval. The recipient receives an award amount of $5,000.

So, what does this honor mean to Cushman? Always humble, he said, "The more we can show we are having impact, the better for our students, college, University, state, country and science."

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Molecular genetics and biosystems design research improves water-use efficiency of plants - Nevada Today

Damn right Im in this march, said Eddy Fischer, 97, professor emeritus of biochemistry at the University of Washington and Nobel Prize co-winner in 1992 for physiology or medicine. He was among thousands gathered at Cal Anderson Park on Capitol Hill.

A crowd of several thousand gathered Saturday at Cal Anderson Park on Seattles Capitol Hill for the March for Science to Seattle Center. It is part of similar marches being held around the world, with scientists, students and research advocates and ordinary citizens conveying an Earth Day global message of scientific freedom without political interference.

Participants holding signs such as Make America smart again and Climate change is real began arriving around 9 a.m.

Anticipation of Seattles march attracted a social-media following second only to the main event in Washington, D.C. Another dozen marches were planned around the state, from Kennewick to Coupeville.

In Seattle, the promised rain began arriving at about 10:45 a.m. , but with temperatures in the low 60s it was relatively nice spring weather for this city.

The event began with a guitarist playing the Star Spangled Banner in Jimi Hendrix style. People cheered.

Among those attending was Julie Smith, of Mountlake Terrace, who had taken the bus to the march with her husband.

She was holding a sign that said, Survived cancer? Thank science!

Smith said, I have a lot of friends who survived cancer. They wouldnt be here if scientists werent investigating cancer.

She perceives an anti-science movement among some politicians. I dont know why, Smith said. I guess they play to their base, fundamentalist Christians.

Also in the crowd: Eddy Fischer, 97, professor emeritus of biochemistry at the University of Washington and Nobel Prize co-winner in 1992 for physiology or medicine.

He was a there using a wheelchair.

Damn right Im in this march, he said.

Of the Trump administration, Fischer said, I know very little about politics. Im appalled by some of the statements coming out of them.

President Donald Trumps proposed budget, if enacted by Congress, would cut nearly 20 percent of funding for the National Institutes of Health (NIH).

Those cuts would be devastating to Seattles medical research community, and the pipeline for critical advances, scientists say. For example, the Fred Hutchinson Cancer Research Center receives 85 percent of its budget from the NIH, or nearly $250 million annually more NIH grants than any other cancer-research center in the nation.

From Germanys Brandenburg Gate to the Washington Monument on Saturday, crowds around the world urged spending what is necessary to make breakthroughs possible.

We didnt choose to be in this battle, but it has come to the point where we have to fight because the stakes are too great, said climate scientist Michael Mann, who regularly clashes with politicians.

Standing on the National Mall in D.C. with thousands soaked by rain Saturday, Mann said that like other scientists, he would rather be in his lab, the field or teaching students. But driving his advocacy are officials who deny his research that shows rising global temperatures.

President Donald Trump, in an Earth Day statement hours after the marches kicked off, said that rigorous science depends not on ideology, but on a spirit of honest inquiry and robust debate. The president also said his administration was committed to advancing scientific research that leads to a better understanding of our environment and of environmental risks.

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Seattle's March for Science draws thousands on Earth Day including a Nobel Prize winner - Seattle Times

The Department of Chemistry and Biochemistry offers Bachelor of Science degrees in chemistry and biochemistry, a Master of Science degree in chemistry and Doctor of Philosophy degrees in chemistry or biochemistry.

The BS chemistry and biochemistry majors both meet the certification requirements of the American Chemical Society. Both majors are excellent preparation for medical, dental, veterinary, or chiropractic school admission. They provide training for students planning to attend graduate school or work in the chemical or biochemical industries. Students in both majors have the option of developing a specialization in secondary (high school) teaching, and students pursuing the chemistry major have the option of developing an emphasis in environmental chemistry or materials science.

The graduate programs in the department lead to the M.S. or Ph.D. degrees in chemistry or a Ph.D. degree in biochemistry. Research programs exist in analytical, biochemistry, chemical education, environmental, organic, and physical chemistry. All students admitted to the graduate program receive a full assistantship to support them during their studies.

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Chemistry & Biochemistry | South Dakota State University

Salt cedar may have gotten a bad rap.

Also known as the flowering tamarisk tree, salt cedar originated in drier areas of Eurasia and has become a major weed in the southwestern United States, where it is considered an invasive species.

Now, biochemistry researchers at Kansas State University may not only exonerate the plant, but also find that it can help remove pollutants from the environment.

Larry Davis, professor of biochemistry and molecular biophysics, and undergraduate researchers Alexcis Barnes, Salina, and Katie McKinley, Shawnee, are working to understand why salt cedar is so prolific.

The plant can tolerate high levels of two things that are toxic to other plants when present in more than trace amounts: salt and boron.

Both can become concentrated from river irrigation, and boron is a common pollutant that finds its way into water from industry such as glass making, facilities burning wood or coal, and other sources.

Boron pollution carries grim implications for agricultural areas.

In the western part of the central valley of California, for example, its a limiting factor, Davis said. Theyre down to about five crops they can grow because the boron contamination makes black spots on lettuce and other plants.

They can still grow sunflowers and canola because they are harvesting the oil and dont care about the leaves.

Research on salt cedar has been scant, and as the plant has spread, people have assumed that it was choking out or even killing native plants.

Davis work may demonstrate that salt cedar is thriving where other plants cant survive because of boron contamination in water and soil.

McKinley, a junior in biochemistry, has worked with Davis for two years.

She conducts experiments with salt cedar to test how much boron the plants can take.

Salt cedars can withstand up to eight times the boron that a normal sunflower can withstand, McKinley said. Thats crazy, because they are much more slow-growing. They withstand up to 250 parts per million, which is a lot. Eight parts per million will kill other things. Its really impressive.

According to McKinley, salt cedars take up boron and then secrete it on their leaves as a film.

The next step is to determine how the plants take up boron and whether they could be used to take boron out of the soil.

Thats where Barnes comes in.

She is studying the channels in cell membranes that allow water and other particles into the plant, known as aquaporins, to see how they work in salt cedar.

When she completes a new aquaporin model, she is hoping to determine whether salt cedar simply excludes boron or takes it up into its tissues.

Another undergraduate in the Davis lab is exploring whether lipids in the roots explain the plants boron resistance.

Understanding these mechanisms may lead to using salt cedar to help remove pollutants from water or soil, a process known as phytoremediation.

Salt cedar could be planted in areas with boron-contaminated water, for instance, and allowed to take up the pollutant, then cut down and used for fuel.

Both McKinley and Barnes are participating in undergraduate research through Kansas State Universitys Developing Scholars Program.

The program offers high-achieving, underrepresented students research experience along with academic, social and financial support.

Barnes said the program helped her learn to manage her time and set priorities, plus develop her scholarly skills.

The program allows you to network and have a developed scholarly education by the end of your undergraduate career, Barnes said. I feel like I would be missing out on something had I not been doing the research.

McKinley agreed and said the lab experience has built her confidence.

It gives you a lot of lab work experience in safety protocol and using the tools and machines. I can do the mass spectrometry, calculate molarity I have physical experience for years doing this. I feel more confident in my skills working in a lab, McKinley said.

Davis supports the program, noting 10 biochemistry majors are in the Developing Scholars Program.

Biochemistry is a growing field, partially because the Medical College Admission Test emphasizes the field.

Barnes and McKinley both hope to enter the medical field.

Barnes wants to attend medical school and McKinley plans to become a pharmacist and work in a hospital or conduct pharmacology research.

Both say incoming freshmen should seek out opportunities to engage in research and find a mentor like Davis.

Its been wonderful to work with Dr. Davis and learn from him, Barnes said. He is so knowledgeable, and hes patient and is good about explaining higher-level concepts to me.

He can explain in ways I can understand or draw them out on paper. He involves me in conversations with other labs and helps me with networking. Hes a wonderful mentor.

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Shawnee researcher at KSU helps unravel tree mystery - The Dispatch

United States Biochemistry Analyzers market is valued at USD XX million in 2016 and is expected to reach USD XX million by the end of 2022, growing at a CAGR of XX% between 2016 and 2022.

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Biochemistry Analyzers Market: Capacity, Production, Revenue ... - MilTech

Biochemistry Analyzer Market report provides key statistics on the market status of the Biochemistry Analyzer Manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the Biochemistry Analyzer industry.

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Table of Contents:

Chapter 1 Overview of Biochemistry Analyzer Market1.1 Brief Overview of Biochemistry Analyzer Industry 1.2 Development of Biochemistry Analyzer Market 1.3 Status of Biochemistry Analyzer Market

Chapter 2 Manufacturing Technology of Biochemistry Analyzer Industry2.1 Development of Biochemistry Analyzer Manufacturing Technology 2.2 Analysis of Biochemistry Analyzer Manufacturing Technology 2.3 Trends of Biochemistry Analyzer Manufacturing Technology

Chapter 3 Analysis of Global Biochemistry Analyzer Market Key Manufacturers3.1.1 Company Profile 3.1.2 Product Information 3.1.3 2012-2017 Production Information 3.1.4 Contact Information

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Chapter 4 2012-2017 Global and Chinese Biochemistry Analyzer Market4.1 2012-2017 Global Capacity, Production and Production Value of Biochemistry Analyzer Market 4.2 2012-2017 Global Cost and Profit of Biochemistry Analyzer Market 4.3 Market Comparison of Global and Chinese Biochemistry Analyzer Industry 4.4 2012-2017 Global and Chinese Supply and Consumption of Biochemistry Analyzer Market 4.5 2012-2017 Chinese Import and Export of Biochemistry Analyzer

Chapter 5 Market Status of Biochemistry Analyzer Industry5.1 Market Competition of Biochemistry Analyzer Industry by Company 5.2 Market Competition of Biochemistry Analyzer Industry by Country (USA, EU, Japan, Chinese etc.) 5.3 Market Analysis of Biochemistry Analyzer Consumption by Application/Type

Chapter 6 2017-2022 Market Forecast of Global and Chinese Biochemistry Analyzer Market6.1 2017-2022 Global and Chinese Capacity, Production, and Production Value of Biochemistry Analyzer market 6.2 2017-2022 Biochemistry Analyzer market Cost and Profit Estimation 6.3 2017-2022 Global and Chinese Biochemistry Analyzer Market Share 6.4 2017-2022 Global and Chinese Supply and Consumption of Biochemistry Analyzer 6.5 2017-2022 Chinese Import and Export of Biochemistry Analyzer

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Biochemistry Analyzer Market Forecast 2022: Global & Chinese Key ... - MilTech