Category Archives: Biology

Multiple reaction monitoring assays for large-scale quantitation of proteins from 20 mouse organs and tissues … – Nature.com

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Multiple reaction monitoring assays for large-scale quantitation of proteins from 20 mouse organs and tissues ... - Nature.com

Calendar of events, awards and opportunities – ASBMB Today

Every week, we update this list with new meetings, awards, scholarships and events to help you advance your career.If youd like us to feature something that youre offering to the bioscience community, email us with the subject line For calendar. ASBMB members offerings take priority, and we do not promote products/services. Learn how to advertise in ASBMB Today.

The Art of Science Communication is an eight-week online course designed to provide you with fundamental training in science communication. Whether you're a professional scientist, educator or a scientist in training, the ASC course will equip you with the knowledge to effectively and confidently present your science to nonexpert audiences in formal and informal settings. The course delves into the essential elements of crafting a compelling presentation through instructional videos, background material, live online discussions and peer-to-peer mentoring. The course starts Jan. 22 and concludes on March 15. Space is limited. You now have until Jan. 7 to reserve your spot.

The Air Force Research LaboratoryScholars Program is administered by Universities Space Research Associationwith the goal of "strengthening the science, technology, engineeringand mathematics workforce pipeline." Undergraduate- and graduate-level university students pursuing STEM degrees and upper-level high school students are invited to apply for the AFRL Scholars Program. Selected students will participate in paid internship opportunities and "gain valuable hands-on experiences working with full-time AFRL scientists and engineers on cutting-edge research and technology and are able to contribute to unique, research-based projects." Learn more.

The Opentrons Flex Nucleic Acid Extraction Workstation is a "benchtop liquid handler with up to 96-sample throughput." At 12 p.m. Eastern on Jan. 10, Opentrons Labworks, Inc. is hosting a webinar about automating nucleic acid extraction, the workstation, and "how to change deck layout, swap a pipette and perform autocalibration." Learn more.

Discover BMB is the annual meeting of the American Society for Biochemistry and Molecular Biology. The 2025 meeting will be held in Chicago, and we're calling on ASBMB members to help shape the programming. Self-nominate yourself today for a speaking slot! This is your chance to let the organizing committee know about your research. Applicants must be regular, industry or early-career members of the ASBMB. To apply, briefly describe (2,000 characters or fewer) your recent work as it relates to one of the 2025 themes. See the themes and apply.Learn more about the call for self-nominations.

The American Society of Gene and Cell Therapy is partnering with the American Association for the Advancement of Scienceto host a one-yearpolicy fellowship on Capitol Hill. "Fellows will provide high-quality, science-based, independent guidance to federal policy makers and elevate awareness of the society among policymaking circles." Learn more.

At 12 p.m. Eastern on Jan. 16, the International Union of Biochemistry and Molecular Biology Trainee Initiative is hosting webinar titled "Addressing mental health in research from scientists for scientists." The online event and panel discussion will feature mental health experts and scientists sharing their experiences. It will cover strategies to manage mental health crises and offer inspiration through personal stories of triumph over adversity. Speakers include Madeline McGhee, a laboratory techician at Massachusetts Institute of Technology, and Alexander Tsai, a psychiatrist and associate professor of psychiatry at Harvard Medical School. Follow the IUBMB Trainee Initiative on Instagram, @iubmb_trainee, for more speaker announcements. Learn more and register.

Genetic Engineering & Biotechnology Newsis hosting a webinar titled "Improved AAV capsid purification via high-resolution chromatography" at 11 a.m. Eastern on Jan. 16. During the webinar, Ale trancar of Sartorius BIA Separations will "discuss various chromatographic methods to consistently separate empty, partial, and full capsids in large-scale AAV manufacturing." Learn more.

Negotiations occur every day in the scientific laboratory and workplace and often involve issues that are key to research success and career advancement. This workshop, co-sponsored by the ASBMB Women in Biochemistry and Molecular Biology Committee and the Committee on the Advancement of Women Chemists, teaches the fundamentals of negotiation relevant to a variety of one-on-one conversations and group settings. Topics include:

At 1 p.m. Eastern on Jan. 17, the Federation of American Societies for Experimental Biology is hosting a webinar about how to create a quality data-management plan for your next National Institutes of Health grant. The webinar will review policy requirements for plans and provide step-by-step guidance. Learn more.

Discover BMB is the annual meeting of the American Society for Biochemistry and Molecular Biology. The 2024 meeting will be held in San Antonio, and we're now accepting late-breaking abstracts for poster presentations. When you present your research at #DiscoverBMB, you get the recognition and constructive feedback that you need to make your work even better. The meeting will be held March 2326 in San Antonio, Texas. See the abstract categories and submit your late-breaking abstract.

Are you a scientist curious about how your expertise can contribute to the greater good? This webinar will help you understand the broad range of government roles beyond what you might ordinarily think of as public sector. From research and innovation to policy development and implementation, the government offers a vast array of avenues for scientists to apply their skills and knowledge. Unlock the door to a world of possibilities as we discuss government careers in the sciences and explore the diverse opportunities available for scientists looking to make a meaningful impact on society. This event is sponsored by the ASBMB Education and Professional Development Committee Graduate/Postdoctoral Subcommittee. Learn more and register for free.

Join the ASBMB public affairs department for its monthly "Finding the funds" webinar connectingASBMB members with the unique funding opportunities that are available to them as BMB scientists. In this edition, Gail McLean of the Department of Energy Office of Science will present on DOE funding priorities, award opportunities and training grants. Learn more.

Genetic Engineering & Biotechnology Newsis hosting a virtual event on Jan. 24 about the state of cell and gene therapy. Speakers from industry and academia will "discuss the latest research developments, innovations, and disruptive technologies that are impacting patients lives today and will spur cell and gene therapies to bigger and better things tomorrow." Learn more.

Science's "Dance Your Ph.D. Contest" is now accepting entries! In this competition, scientists are invited to explain their research through dance. Here are the steps to enter, from Science Magazine's LinkedIn:

There are three prizes. The first two categories come with $750 prizes and are"physics, biology, chemistryand social science" and "AI/quantum." The top prize, for "Dance Champ," is $2,000. Learn more.

This webinarhosted by Brukerwill "overview the versatile roles of NMR spectroscopy in RNA drug discovery for providing the structural basis for the rational drug design. Advanced techniques for simplifying crowded spectra of large RNAs will be discussed." Learn more.

FASEB's Catalyst Conferences are "short, virtual meetings that are intended to help foster communities in emerging areas of biology." This is the first Catalyst Conference of 2024, and it "will bring together scientists to discuss on the many unresolved and still debated issues on TDP-43 structure, biology, misbehaviorand involvement in diseases." Learn more.

The Centre for Predictive Human Model Systems (CPHMS) is hosting a webinar on how single-cell transcriptomics can help researchers untangle the intricacies of oral cancer. At 4 p.m. Indian Standard Time (5:30 a.m. Eastern Time) on Feb. 2, Arindam Maitra at the National Institute of Biomedical Genomics, West Bengal will share about his research on gingiva-buccal oral cancer. Learn more.

The Lasker Foundation is accepting nominations for the 2024 Lasker Awards in biomedical research and advocacy. Prize categories include: Basic Medical Research, Clinical Medical Researchand Public Service. Winners will receive a $250,000 honorarium. "Since 1945, the Lasker Foundation has conferred more than 410 awards, which recognize the contributions of scientists, physicians, and public citizens who have made major advances in the understanding, diagnosis, treatment, cure, and prevention of human disease." Learn more.

At 1 p.m. Eastern on Feb. 14, FASEBis hosting a webinar titled"5 reasons we can't publish your dataset." This virtual conversation will cover "best practices for preparing datasets and how to avoid common mistakes," plus "some of the most common reasons data is sent back to authors" to help attendees ensure their dataset is published rapidly and smoothly. Learn more.

The NIH's Summer Internship Program is "an opportunity for students in college, graduate, and professional school to perform a summer research internship in the Intramural Research Program at the NIH." Interns work with a principal investigator and research opportunities include: "biomedical, behavioral, and social sciences with opportunities to explore basic, translationaland clinical research." There will be a Q&A webinar at 3 p.m. Eastern on Jan. 4. Learn more.

In observance of Rare Disease Week, the Food & Drug Administration will host a virtual public meeting on March 1 from 9 a.m.4:30 p.m. Eastern. Topics that will be covered during panel discussionsinclude "the legal framework for approving studies and medical products at FDA, what FDA does during review processes to approve medical products, decentralized clinical trials and digital health technologies" and more. As stated in the event description, "stakeholders are invited to provide their perspectives on the discussion questions through the public docket." Learn more.

The 2024 National Postdoctoral Conference will be held in Seattle. It is "the largest national conference and networking event dedicated to the postdoctoral community " during which attendees will have the "opportunity to gather and enhance their professional development and leadership skills." Learn more.

#DiscoverBMB is the annual meeting of the American Society for Biochemistry and Molecular Biology. With a mission to share the latest, most impactful research findings in the molecular life sciences, #DiscoverBMB offers an exciting agenda that includes talks by the field's foremost experts, interactive workshops on the latest trends, technologies and techniques, and an invigorating exhibition of posters, services and products. The meeting attracts researchers in academia and industry, educators, trainees and students from across the globe. It offers unparalleled opportunities for collaborating, networking and recruiting. See the symposia themes and organizers.Learn more.

The Scientist Mentoring & Diversity Program is a one-year career mentoring program that pairs ethnically diverse students (undergraduate juniors and seniors, baccalaureate, master's or Ph.D.), postdocs and early-career researchers with industry mentors "who work at companies in the medical technology, biotechnology and consumer healthcare industries." Scholars will attend a five-day training session "to learn about career opportunities in industry and receive career development coaching. They also attend a major industry conference." Learn more.

The fields of transcription biochemistry and molecular biology have become one with chromatin biology and epigenetics with extensive cross-talk. RNA polymerase II and its transcription machinery play an essential role in the modification and remodeling of chromatin,and chromatin regulates gene expression in both normal and pathological conditions. With recent innovations and technological advances in clinical and preclinical research, personalized medicine is becoming a reality, in part because of advances in our understanding of RNA polymerase II. Many established and new investigators have taken on the challenge of elucidating the molecular mechanisms of gene expression by RNA polymerase II in the context of chromatin. The community is highly dynamic and multi-disciplinary, with an ever-changing set of focal areas that establish new paradigms and new ways of thinking about the topic. Even after decades of study, this research area continues to advance, reveal new concepts, and bolsters almost every other area of biology. Learn more.

The 2025 Deuel conference will be hosted at the Hyatt Regency in Long Beach, Calif. It is a must-attend event for leading lipids investigators and for scientists whove just begun to explore the role of lipids in their research programs. This event will bring together a diverse array of people including those who have not attended Deuel or perhaps any lipid meeting before. The conference is a forum for the presentation of new and unpublished data, and attendees enjoy the informal atmosphere that encourages free and open discussion. Interested scientists are invited to attend and encourage trainees to submit abstracts. Learn more.

This five-day symposium, held at the Broad Institute of MIT and Harvard in Cambridge, Mass., will be an international forum for discussion of the remarkable advances in cell and human protein biology revealed by ever-more-innovative and powerful proteomics technologies. Formerly known as the "International symposium on mass spectrometry in the health and life sciences," the meeting has been renamed to reflect the growing number of partial and non-mass spectrometrybased methods under discussion.

The symposium will juxtapose sessions about methodological advances with sessions about the roles those advances play in solving problems and seizing opportunities to understand the composition, dynamics and function of cellular machinery in numerous biological contexts. In addition to celebrating these successes, we also intend to articulate urgent, unmet needs and unsolved problems that will drive the field in the future. In addition to talks by invited plenary and session speakers, short talks will be selected from submitted abstracts. See the program of our previous meeting.

Themes:

We are now accepting proposals for scientific events to be held in 2024 and 2025. You pick the topic, the sessions and the speakers, and well do the rest.

Thats right! Well manage registration, market the event to tens of thousands of scientists, and handle all the logistics so that you can focus on the science.

The top areas of research interest among ASBMB members include the following, but well consider all proposals:

What molecule, method or research question needs more attention? Were here to help you realize your vision and deliver cutting-edge science to the BMB community.

Propose an event.

Van Andel Institute offers sernior graduate studentswho are exploring postdoc optionsthe opportunity to visit VAI to learn about its postdoctoral training positions. Applications are accepted year-round, and participants will meet one-on-one with faculty and explore VAI's scientific resources.There is no cost to attend for selected applicants. Learn more.

Graduate students, postdoctoral fellows and established senior investigators are all invited to participate in Janelia's Visiting Scientist Program. Janelia accepts visitor proposals on a continuous basis. Since 2007, more than 410 visiting scientists from 23 countries have participated in the program. Learn more.

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Calendar of events, awards and opportunities - ASBMB Today

Cell type evolution reconstruction across species through cell phylogenies of single-cell RNA sequencing data – Nature.com

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Cell type evolution reconstruction across species through cell phylogenies of single-cell RNA sequencing data - Nature.com

Glycoscience Explained: The Sugar Coating of Life – SciTechDaily

Glycobiology, evolving beyond its roots in carbohydrate chemistry, is now a key field in understanding lifes molecular mechanisms. Glycans, essential in various biological functions, are the focus of groundbreaking research and technological innovations, revealing their critical roles in health and disease. Credit: SciTechDaily.com

Researchers are working to advance the field of glycoscience, illuminating the essential role of carbohydrates for human health and disease.

In the narrowest sense, glycobiology is the study of the structure, biology, and evolution of glycans, the carbohydrates and sugar-coated molecules found in every living organism. As a recent symposium at MIT made clear, the field is in the midst of a renaissance that could reshape scientists understanding of the building blocks of life.

Originally coined in the 1980s to describe the merging of traditional research in carbohydrate chemistry and biochemistry, glycobiology has come to encompass a much broader and multidisciplinary set of ideas. Glycoscience may actually be a more appropriate name for the rapidly growing field, reflecting its broad application not just to biology and chemistry but also to bioengineering, medicine, materials science, and more.

Its becoming increasingly clear that these glycans have a very important role to play in health and disease, says Laura Kiessling, the Novartis Professor of Chemistry. It may seem daunting initially, but devising new tools and identifying new kinds of interactions requires exactly the sort of creative problem-solving skills that people have at MIT.

Glycans include a diverse set of molecules with linear and branched structures that are critical for basic biological functions. With no known exception, all cells in nature are coated with these sugar molecules from the intricate chains of sugars surrounding most cellular surfaces to the conjugated molecules formed when sugars attach like scaffolding to lipids and proteins. Theyre absolutely fundamental to life. For example, Kiessling points out that the most abundant organic molecule on the planet is the carbohydrate cellulose.

Sperm-egg binding is mediated by an interaction between a protein and a carbohydrate, she says. None of us would exist without these interactions.

Though talking about carbs and sugars might leave some people focused on their diet, glycans are actually among the most important biomolecules out there. They store energy and, in some cases like cellulose, provide the structural framework for multicellular organisms. They mediate communication between cells; influence interactions like that between a host and parasite; and shape immune responses, disease progression, development, and physiology.

In Professor Laura Kiesslings lab, researchers are working to understand the protein-carbohydrate interactions at a molecular level, such as the protein human intelectin-1 (hiTLN-1) shown here. Understanding the proteins glycobiology could facilitate the development of new antibiotics and antimicrobial therapeutics. Credit: Kiessling Lab

It turns out that some of these structures, which we didnt even know existed in the body in such abundance until recently, have so many different biological functions, says Andrew and Erna Viterbi Professor of Biological Engineering Katharina Ribbeck. With this rapid expansion of knowledge, it feels like were just beginning to understand how diverse and important those functions are to biology.

With a better understanding of how ubiquitous and critical these molecules are, researchers in applied fields like biotechnology and medicine have turned their attention to glycoscience as a tool to pinpoint the drivers of disease.

Many conditions have been linked to defects in how glycans are produced in the body or issues with glycosylation, the process by which carbohydrates attach to proteins and other molecules. That includes certain forms of cancer. Cancer cells have even been shown to cloak themselves in certain glycoproteins to evade an immune response.

On the flip side, glycans may be a repository of potential therapeutics. The blood thinner Heparin, one of the worlds best-selling prescription drugs, for example, is a carbohydrate-based drug.

Glycans and sugar-binding proteins like lectins even help influence the exchange of microbes across mucus layers in the human body, from the brain to the gut. Glycans dangling off mucus interact with microbes, letting good ones in and reducing the virulence of problematic ones by interrupting cell signaling or stopping pathogens from releasing toxins.

Despite how crucial this sugar coat is, for a long time, molecular biologists focused on nucleic acids and proteins, paying relatively little attention to the sugars that coated them.

The tools we have to examine the functions of other molecules are largely absent for glycans, says Kiessling, who is also an institute member of the Broad Institute of MIT and Harvard.

For example, the DNA and RNA sequences of a cell predict what proteins that cell makes, so scientists can track where a protein is and what its doing using a genetically-encoded tag. But the structure of glycans isnt so obviously encoded in a cells DNA, and a single protein can be decorated with many different chains of carbohydrates.

In addition, the immense diversity of forms carbohydrates can take, and the fact that they break down quickly in the bloodstream, has made it challenging to synthesize glycans or target them for drug development. So, creative new methods are needed to track them.

Its a classic chicken-and-egg situation. As scientists better understand the importance of glycans for so many biological processes, it has incentivized them to develop better tools for studying glycans, in turn, producing even more data on just what these molecules can do. In 2022, in fact, the Nobel Prize was awarded to Carolyn Bertozzi at Stanford University, a pioneer in glycobiology, for her work on tracking molecules in cells, which she and others have applied to glycans.

But artificial intelligence could facilitate an evolutionary leap in the field.

I think glycobiology is, more than almost any other field, ripe and ready for an AI interpretation, Ribbeck says, explaining how AI might enable scientists to read the glycan code in the same way they have with the human genome. That would allow researchers to predict the actual function of a glycan based on data about its structure. From there, they could identify what changes lead to disease or increase disease susceptibility and, most importantly, come up with ways to repair those defects.

The increasing interest in computation reflects the inherent interdisciplinarity that has defined glycoscience from the beginning.

Just at MIT, for example, related research is happening across the Institute. Kiessling describes MIT as a playground for interdisciplinary research, which has enabled significant advances in the field with applications to biotechnology, cancer research, brain science, immunology, and more.

In the Department of Chemistry, Kiessling is studying carbohydrate-binding proteins, and how their interactions with glycans affect the immune system. Shes also working with Bryan Bryson, an associate professor in the Department of Biological Engineering, and Deborah Hung, a core faculty member at The Broad Institute of MIT and Harvard, using carbohydrate analogs to test differences in strains of tuberculosis in South Africa. Meanwhile, assistant professor of biological engineering Jessica Stark is pioneering approaches to better understand the roles of glycans in the immune system. Tobi Oni, a fellow at the Whitehead Institute for Biomedical Research, is looking to glycans to help detect and target tumors in pancreatic cancer. Barbara Imperiali, the Class of 1922 Professor of Biology and Chemistry, is studying the carbohydrates that envelop the cells of microbes like bacteria, and Professor Matthew Shoulders in the Department of Chemistry is studying the role of glycans in synthesizing and folding proteins.

Were at a very exciting and unique position combining disciplines to address and answer entirely new questions relevant for disease and health, says Ribbeck.The field in and of itself is not new, but what is new is the contribution that MIT, in particular, could make with a creative combination of science, engineering, and computation.

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Glycoscience Explained: The Sugar Coating of Life - SciTechDaily

Charleroi biology students team up online with scientists for research projects – The Mon Valley Independent

Submitted Shown, from left, are Charleroi Advanced Placement biology students Bailey Gillen, Addacie Durka, Angela Mathers, Suki Yu, Lairah Dipietrantonio and McKenna Shields. They recently had their work on two separate projects featured on planting science.org. Missing from the photo is Aiden Iadanza, who also participated on one of the teams.

By TAYLOR BROWN Senior Reporter [emailprotected] Charleroi High School Advanced Placement biology students will have their work recognized as model projects for other learners. The project got its start after CAHS science teacher Michele Piatt participated in a research study funded by the National Science Foundation to determine if in-person teacher professional development is more effective than virtual teacher training based on student outcomes. As part of the project, her AP biology students completed several lab activities on the bioenergetic processes of photosynthesis and cell respiration using the plantingscience.org website investigation theme, Power of Sunlight. Students were divided into small groups and each group was assigned to their own scientist mentor that they communicated with on the plantingscience.org platform throughout their investigations. The scientist mentors were volunteers who work in the plant science field all over the world. The project ended with the students designing their own experiment and sharing their results with their scientist mentor. Two of the groups in Piatts AP biology class had their projects nominated, judged and were awarded recognition as Star Projects, which will now be used as models for other learners and researchers. The group Lets Take a Cellfie comprised students Lairah Dipietrantonio, Angela Mathers, McKenna Shields and Suki Yu. Their mentor, Nora Gavin-Smyth, works at the Chicago Botanic Garden and Northwestern University. The goal of their project was to see if the pH of a solution would increase/decrease with the presence of either oxygen or cellular respiration. This group really worked together to communicate with their scientist mentor at every step of the investigation, Piatt said. They were vary thorough in their discussions and asked intriguing questions. The design of their experiment was innovative as they used additional materials beyond the Planting Science investigations. The second group, Plants vs. AP Bio comprised Addacie Durka, Bailey Gillen and Aiden Iadanza.

To read the rest of the story, please see a copy of Thursdays Mon Valley Independent, call 724-314-0035 to subscribe or subscribe to our online edition at http://monvalleyindependent.com.

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Charleroi biology students team up online with scientists for research projects - The Mon Valley Independent

The Southern Poverty Law Center’s New Enemy: Americans Who Accept Biology – Quillette

The Montgomery, Alabama-based Southern Poverty Law Center (SPLC) was founded in 1971 with a mission to fight poverty and racial discrimination. Its early litigation campaigns, which targeted the Ku Klux Klan and other overtly racist organizations, met with success, and the group soon came to be seen as an authoritative source in regard to right-wing extremism more generally.

Another form of expertise the organization developed was in the area of marketingespecially when the market in question consisted of deep-pocketed urban liberals. As former SPLC staffer Bob Moser reported in a 2019 New Yorker article, the group has consistently taken on attention-grabbing urgent-seeming causes that its leaders knew could be leveraged as a means to gain publicity andmore importantlydonations. Its no coincidence that the SPLCs co-founder and long-time fundraising guru, Morris Dees, had previously operated a direct-mail business that sold cookbooks and tchotchkes. Whether youre selling cakes or causes, its all the same, Dees told a journalist in 1988.

The Reckoning of Morris Dees and the Southern Poverty Law Center

The work at the S.P.L.C. could be meaningful and gratifying. But it was hard, for many of us there, not to feel like wed become pawns in what was, in many respects, a highly profitable scam.

Dees big fundraising break at the SPLC came when he got access to the direct-mail list from the 1972 presidential campaign of Democrat George McGovern. The SPLC co-founder went on to maximize the SPLCs revenues through what would now be known as targeted methods. According to one former legal colleague, for instance, Dees rarely used his middle nameSeligmanin SPLC mailings, except when it came to Jewish zip codes.

Thanks to Dees slick marketing expertise, the SPLC was eventually taking in more money than it paid out in operational expenses. (As of October 2022, its endowment fund was valued at almost US$640 million.) But over time, his hard-sell tactics began to alienate co-workers, as there was an obvious disconnect between the real class-based problems they observed in society and the fixations of the nave northern donors whose wallets Dees was seeking to pry open.

I felt that [Dees] was on the Klan kick because it was such an easy targeteasy to beat in court, easy to raise big money on, former SPLC attorney Deborah Ellis told Progressive writer John Egerton. The Klan is no longer one of the Souths biggest problemsnot because racism has gone away, but because the racists simply cant get away with terrorism any more.

How the Southern Poverty Law Center got Rich Fighting the Klan

SPLCs current meltdown was a long time coming. Our 1988 magazine story investigates the spectacular success of the center and the pivotal role of the fundraising gladiator, Morris Dees.

On March 14, 2019, Deesby now 82 years old, but still listed as the SPLCs chief trial lawyerwas fired amid widespread rumors that hed been the subject of internal sexual-harassment accusations. His affiliation was scrubbed from the groups web site; and the organizations president, Richard Cohen, cryptically (but damningly) declared that, when one of our own fails to meet [SPLC] standards, no matter his or her role in the organization, we take it seriously and must take appropriate action. (Less than two weeks later, Cohen himself left the organization, casting his resignation as part of a transition to a new generation of leaders.)

In describing his tenure at the SPLC during the early 2000s, Moser argued that the very structure of the organization betrayed its hypocrisy: Here was an entity dedicated to social justice (as we would now call it), yet which was run by an extremely well-paid, almost exclusively white, corps of lawyers, administrators, and fund-raisers who ruled over a mixed-race corps of junior staff. As far back as the 1980s, Dees was openly admitting that he saw the fight against poverty as pass, and admitted that the P in SPLC was an anachronism. Jaded staff began ruefully referring to their own flashy headquarters as the Poverty Palace.

Dees and Cohen may have left the Poverty Palace, but the SPLCs tendency to betray its founding principles clearly remains a problem, as illustrated by a new SPLC report released under the auspices of what the group dubs Combating Anti-LGBTQ+ Pseudoscience Through Accessible Informative Narratives. (This verbal clunker seems to have been reverse-engineered in order to yield the acronym, CAPTAIN.)

The report purports to demonstrate the perils of anti-LGBTQ+ pseudoscience and anti-trans narratives and extremism. Much like the dramatically worded hard-sell direct-mail campaigns that the SPLC started up under Dees, its marketed as a matter of life and death: According to the deputy director of research for the SPLCs Intelligence Project, the anti-LGBTQ+ pseudoscience uncovered by the SPLC has real-life, often life-threatening consequences for trans and non-binary people.

At this point, it should be stressed that there is certainly nothing wrong with the SPLCor anyone elsecampaigning for the legitimate rights of people who are transgender. Such a campaign would be entirely in keeping with the SPLCs original liberal ethos. Just as no one should be denied, say, an apartment, a marriage license, or the right to vote based on his or her race, religion, sex, or sexual orientation, no trans person should be denied these rights and amenities simply because he or she experiences gender dysphoria.

But the SPLCs report hardly confines itself to such unassailable liberal principles. The real point of the project, it seems, was to catalogue and denounce public figures whove expressed dissent from the most extreme demands of trans-rights activistsspecifically, (1) the demand that children and adolescents who present as transgender must instantly be affirmed in their dysphoric beliefs, even if such affirmation leads to a life of sterility, surgical disfigurement, drug dependence, and medical complications; and (2) the demand that biological men who self-identify as women must be permitted unfettered access to protected womens spaces and sports leagues.

The SPLCs authors seek to cast their ideological enemies as hate-addled reactionaries whose nefarious activities must be understood as part of the historical legacy of white supremacy and the political aims of the religious right. And it is absolutely true that some of the organizations they name-check are hard-right, socially conservative outfits that endorse truly transphobic (and homophobic) beliefs.

But many of the supposed transphobes targeted by the report arent even conservativelet alone members of the religious right. In a multitude of cases, theyre simply parents, therapists, and activists who argue the obvious fact that human sexual biology doesnt evanesce into rainbow dust the moment that a childor middle-aged manasserts that he or she was born in the wrong body.

Its also interesting to note who gets left out of the SPLCs analysis. The most influential figures leading the backlash against (what some call) gender ideology are women such as author J.K. Rowling and tennis legend Martina Navratilova, both of whom come at the issue from explicitly feminist perspectives. Being successful public figures, neither woman needs a cent from the conservative think tanks that the SPLC presents as being back-office puppet-masters of the alleged anti-trans conspiracy outlined in the CAPTAIN report.

In keeping with the conspiracist motif that runs through the document, the authors have provided spider-web diagrams that set out the connections binding this (apparently) shadowy cabal. In this regard, it seems that Quillette itself served as one of the SPLCs sources: In a section titled, Group Dynamics and Division of Labor within the Anti-LGBTQ+ Pseudoscience Network, the authors footnote an August 23, 2023 podcast for Quillette, wherein

Weve chosen to highlight this particular (typo-riddled) text from the report not just because of the absurd suggestion that our publication has enlisted in an imaginary anti-LGBTQ+ pseudoscience network, but also because the above-quoted roll call of supposed gender villains illustrates the intellectual dishonesty that suffuses the whole report.

Lets go through the references one by one, in the order in which they are presented. The Gender Dysphoria Alliance (GDA) is a group led by people who are themselves transgender, and who are concerned about the direction that gender medicine and activism has taken. Are we to imagine that its members are directing transphobiaagainst themselves? Lisa Littman, formerly of Brown University, is a respected academic whos published a peer-reviewed analysis of Rapid Onset Gender Disorder. Ray Blanchard is a well-known University of Toronto psychiatrist. The Archives of Sexual Behavior is a peer-reviewed academic journal in sexology. Michael Bailey is a specialist in sexual orientation and gender nonconformity at Northwestern University. Colin Wright is a widely published writer (including at Quillette) with a PhD in evolutionary biology from UC Santa Barbara. (The SPLCs claim that he is in a relationship with journalist Christina Buttons, who also writes about gender issues, is completely true. But the fact that the group saw fit to report this fact as if it were evidence of sinister machinations says far more about the reports authors than it does about either Wright or Buttons.) FAIR, the Foundation Against Intolerance & Racism, is a classically liberal group led by a Harvard Law School graduate named Monica Harris. Do any of these people or groups sound like extremists?

The fact that the SPLC is attempting to market its report as a blow against the anti-LGBTQ+ movement, writ large, is itself quite laughable, since many of the activists whove been arguing for a more balanced approach to gender rights are themselves either gay (as with Navratilova and Julie Bindel) or (as with the founders of the GDA) transgender.

Others on the SPLC gender-enemies list are author Abigail Shrier, and therapists Sasha Ayad, and Stella OMalley. These women openly broadcast their views in best-selling books, as well as mainstream magazines and newspapers. The idea that the SPLC has successfully exposed these women through some kind of investigation, as suggested by the title thats been slapped on the CAPTAIN report, would be ludicrous even if theyd said anything scandalous (which they havent).

And what course of future action does the SPLC endorse? For one, it concludes that educators should stigmatize gender-critical views as analogous to racism, sexism, and heteronormativity. The report's authors also want academic journals to sniff out groups that espouse an anti-LGBTQ+ ideology (as that latter term is speciously defined by the SPLC). And in a final flourish, the group urges reporters to be aware of the narrative manipulation strategies and the cooptation of scientific credentials and language by anti-trans researchers when sourcing stories about trans experiences.

With this last point, we get to the real nub: The apparent goal is for this report to be read as a catalogue of people, ideas, and groups that must be shunned. Indeed, the authors explicitly cite the work of one Andrea James, a once-respected arts producer who, as Jesse Singal has documented, now runs a creepy (stalker is the word Singal uses) web site called Transgender Map, which lists personal details of anyone whom James deems a gender heretic. When it comes to one-on-one communication, James manner of dealing with critics is exemplified by an email sent to bioethicist Alice Dreger, in which James referred to Dregers then-five-year-old son as a womb turd.

The rage behind Transgender Map

An activist media ecosystem enabled Andrea James

One way to describe the CAPTAIN report is as an SPLC-branded rehash of the information contained on Transgender Map. And one can understand why the authors thought that such a gambit might work. The SPLC already publishes other curated lists of hatemongerse.g., its Hatewatch service, Hate Map, and Intelligence Report. It wasnt such a long shot to imagine that this new report might convince readers to treat the listed Anti-LGBTQ+ Pseudoscience Network acolytes as equally disreputable.

But if that was the authors goal, it doesnt seem to have been achieved. The SPLC report landed with something of a thudand has attracted little attention on social media except insofar as it was mocked by its intended targets.

This may have something to do with the reports timing. For several years now, a backlash against this kind of gender agitprop has been building within many of the same liberal and progressive circles that the SPLC has traditionally targeted for donations. The trend is reflected by the rise of such groups as the LGB Alliance, a coalition of lesbian, gay, and bisexual people who are fed up with the ideological takeover of LGBT groups by a militant subset of trans activists.

The same trend is playing out internationally. While the SPLC does its best to heap blame on Americas conservative Christians, many of western Europes governments (none of which are in thrall to the Heritage Foundation or the Charles Koch Foundation) have been following a more gender-critical path for years.

Just a week after the SPLC put out its report, in fact, the UK government published new guidelines advising teachers that they have no duty to automatically affirm a childs assertion that he or she is transgender; and that, in considering such situations, teachers should speak with a childs parents and consider whether the child is under undue influence from social media or peers. Sweden, Finland, and Norwayhardly bastions of Christian conservatismhave also rolled back policies that rush children into transition. In Canada, several provinces have recently enacted rules that require parents to be notified when a child seeks to transition, even in the face of a sustained media campaign that repeats lurid claims to the effect that such policies will cause an epidemic of trans suicides. Are all of these foreign governments also complicit in the vast junk-science and disinformation campaign against trans people that the SPLC claims to have exposed?

The SPLC would hardly be the first progressive organization whose reputation has suffered by going all-in on the gender issue. The American Civil Liberties Union, which also was rooted in traditional liberal values before succumbing to more faddish progressive tendencies, has attracted ridicule due to its parroting of slogans such as men who get their periods are men, and the claim that males have no unfair advantage over females in sports.

These organizations have never been shy about angering conservatives and reactionaries; indeed, they wear such anger as a badge of pride. But their cultish refusal to engage with the reality of biological sex also antagonizes progressive feminists seeking to protect female spaces from biological men, and LGB activists who see the attempted erasure of sex-based attraction as a species of progressive homophobia.

Which is to say that the SPLCs report seems not only intellectually dishonest, but also self-destructive. While the SPLC leaders who green-lit this project once may have been able to bank on the popularity of pronoun checks and esoteric gender identities among the wealthy white coastal progressives who comprise the bulk of their donors, this is an ideological movement thats decidedly past its peak. Its a marketing error that the savvy Dees likely never would have made.

The SPLC obviously does a lot more than lend its name to sloppily edited gender propaganda: A review of its press feed shows that it still has staff working traditional legal beats such as voters rights, police accountability, and humane treatment for prisoners. But when an organization publishes misleading materials in regard to one issue, the natural effect is to raise serious questions about the groups values and credibility more generallyquestions that SPLC supporters will want to think about the next time one of the groups fundraisers hits them up for a donation.

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The Southern Poverty Law Center's New Enemy: Americans Who Accept Biology - Quillette

Why ‘resurrection biology’ is gaining traction around the world – FOX 17 West Michigan News

(CNN) Resurrection biology attempting to bring strings of molecules and more complex organisms back to life is gaining traction in labs around the world.

The work is a far cry from the genetically engineered dinosaurs that escape in the blockbuster movie Jurassic Park, although for some scientists the ultimate goal is de-extinction and resurrecting animals and plants that have been lost.

Other researchers are looking to the past for new sources of drugs or to sound an alarm about the possibility of long-dormant pathogens. The field of study is also about recreating elements of human history in an attempt to better understand how our ancestors might have lived and died.

Here are four fascinating research projects in this emerging field that launched or made significant progress in 2023.

Warmer temperatures in the Arctic are thawing the regions permafrost a frozen layer of soil beneath the ground and potentially stirring viruses that, after lying dormant for tens of thousands of years, could endanger animal and human health.

Jean-Michel Claverie, a professor emeritus of medicine and genomics at the Aix-Marseille University School of Medicine in Marseille, France, is seeking to better understand the risks posed by what he describes as zombie viruses by resurrecting viruses from earth samples from Siberia.

Claverie managed to revive a virus in 2014 that he and his team isolated from the permafrost, making it infectious for the first time in 30,000 years by inserting it into cultured cells. In his latest research, published in February, Claverie and his team isolated several strains of ancient virus from multiple samples of earth representing five new families of viruses. For safety, he had chosen to study a virus that could only target single-celled amoebas, not animals or humans.

The oldest was nearly 48,500 years old, based on radiocarbon dating of the soil, and came from a sample of earth taken from an underground lake 52 feet (16 meters) below the surface. The youngest samples, found in the stomach contents and coat of a woolly mammoths remains, were 27,000 years old.

That amoeba-infecting viruses are still infectious after so long is a signal of a serious potential public health threat, Claverie said.

We view these amoeba-infecting viruses as surrogates for all other possible viruses that might be in the permafrost, Claverie told CNN earlier this year.

Our reasoning is that if the amoeba viruses are still alive, there is no reason why the other viruses will not be still alive, and capable of infecting their own hosts.

For bioengineering pioneer Csar de la Fuente, Presidential Assistant Professor at the University of Pennsylvania, the past is a source of opportunity that has opened up a new front in the fight against drug-resistant superbugs.

Advances in the recovery of ancient DNA from fossils mean that detailed libraries of genetic information about extinct human relatives and long-lost animals are now publicly available.

The machine biology group he leads at UPenn uses intelligence-based computational methods to mine this genetic information and identify small protein, or peptide, molecules they believe to have bacteria-fighting powers. He has discovered promising compounds from Neanderthals and ice age creatures such as the woolly mammoth and giant sloth.

It has enabled us to uncover new sequences, new types of molecules that we have not previously found in living organisms, expanding the way we think about molecular diversity, de la Fuente said. Bacteria from today have never faced those molecules so they may give us a better opportunity at targeting the pathogens that are problematic today.

Most antibiotics come from bacteria and fungi and have been discovered by screening microorganisms that live in soil. But in recent decades, pathogens have become resistant to many of these drugs because of widespread overuse.

While de la Fuentes approach is unorthodox, the urgency to identify possible candidates has never been greater as the global population faces nearly 5 million deaths every year that are associated with microbial resistance, according to the World Health Organization.

Extinctions are happening at a faster pace than ever. For some scientists, a path to staunching this loss could be trying to resurrect lost creatures from the past.

Biotechnology and genetic engineering startup Colossal Biosciences announced in January that it wants to bring back the dodo an odd-looking flightless bird that lived on the island of Mauritius in the Indian Ocean until the late 17th century and reintroduce it to its once native habitat.

The company is working on other equally ambitious projects that will incorporate advances in ancient DNA sequencing, gene-editing technology and synthetic biology to bring back the woolly mammoth and the thylacine, or Tasmanian tiger.

Geneticists at Colossal Biosciences have found cells that act as a precursor for ovaries or testes in the Nicobar pigeon, the dodos closest living relative, that can grow successfully in a chicken embryo. The scientists are now investigating whether these cells called primordial germ cells, or PGCs can turn into sperm and eggs.

The company plans to compare the genomes of the dodo and the Rodrigues solitaire, an extinct bird closely related to the dodo, to identify how they differ. Then it will edit the PGCs of a Nicobar pigeon so it expresses the physical traits of a dodo.

The edited cells will then be inserted into the embryos of a sterile chicken and rooster. With the introduction of the edited PGCs, the chicken and rooster will be capable of reproducing, and, in theory, their offspring will resemble the dodo thanks to the hybridized pigeon DNA in their reproductive systems.

Physically, the restored dodo will be indiscernible from what we know of the dodos appearance, said Matt James, chief animal officer of Colossal Biosciences, told CNN in a November email.

Even if the researchers are successful in this high-stakes endeavor, they wont be making a carbon copy of the dodo that lived four centuries ago but an altered, hybrid form instead.

Colossal Biosciences has partnered with the Mauritian Wildlife Foundation to conduct a feasibility study to assess where to best locate the birds if the experiment is successful. However, finding a home may prove challenging.

Mauritius is a relatively small island that has changed significantly since the dodo went extinct.

Despite being one of the most famous birds in the world, we still know virtually nothing about the dodo, so how it interacted with its environment is impossible to know, said Julian Hume, an avian paleontologist and research associate at Londons Natural History Museum, who has studied the bird.

Because of the complexity of recreating a species from DNA, even if it was possible, (it) can only result in a dodo-esque creature. It will then take years of selective breeding to enhance a small pigeon into a large flightless bird. Remember, nature took millions of years for this to happen with the dodo, he added.

Visitors to Denmarks Moesgaard Museum can sniff the scent of an Egyptian mummification balm last used 3,500 years ago.

The evocative smell was recreated from ingredients identified by studying residues left in two canopic jars discovered in Egypts Valley of the Kings in 1900. The two jars once contained some of the remains of an ancient Egyptian noblewoman known as Senetnay.

The exact recipes used in the mummification process have long been debated because ancient Egyptian texts dont name precise ingredients.

The invesetigation, led by Barbara Huber, a doctoral researcher of archaeological chemistry at the Max Planck Institute of Geoanthropology in Germany, identified the balm ingredients using a variety of highly advanced analytical techniques.

She found the balms contained beeswax, plant oils, animal fats, resins and the naturally occurring petroleum product bitumen. Compounds such as coumarin and benzoic acid were also present. Coumarin, which has a vanilla-like scent, is found in pea plants and cinnamon, while benzoic acid occurs in resins and gums from trees and bushes.

The balms differed slightly between the two jars, which means that different ingredients may have been used depending on which organ was being preserved.

In the jar used to store Senetnays lungs, researchers detected fragrant resins from larch trees and something thats either dammar from trees found in India and Southeast Asia, or resin from Pistacia trees that belong to the cashew family.

The presence of such a vast array of ingredients, including exotic substances like dammar or Pistacia tree resin, indicates that extremely rare and expensive materials were used for her embalming, Huber told CNN when the research was published in August. This points to Senetnays exceptional status in society.

The scent was then recreated with the help of French perfumer Carole Calvez and sensory museologist Sofia Collette Ehrich.

The first time I encountered the scent, it was a profound and almost surreal experience, Huber said.

After spending so much time immersed in the research and analysis, to finally have this tangible, aromatic connection to the ancient world was moving. It was like holding a faint echo from the past.

Editor's note:CNNs Ashley Strickland and Tom Page contributed to this report

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Why 'resurrection biology' is gaining traction around the world - FOX 17 West Michigan News

50-year-old muscles just can’t grow big like they used to the biology of how muscles change with age – Yahoo News

There is perhaps no better way to see the absolute pinnacle of human athletic abilities than by watching the Olympics. But at the Olympics and at almost all professional sporting events you rarely see a competitor over 40 years old and almost never see a single athlete over 50. This is because with every additional year spent on Earth, bodies age and muscles dont respond to exercise the same as they used to.

I lead a team of scientists who study the health benefits of exercise, strength training and diet in older people. We investigate how older people respond to exercise and try to understand the underlying biological mechanisms that cause muscles to increase in size and strength after resistance or strength training.

Old and young people build muscle in the same way. But as you age, many of the biological processes that turn exercise into muscle become less effective. This makes it harder for older people to build strength but also makes it that much more important for everyone to continue exercising as they age.

The exercise I study is the type that makes you stronger. Strength training includes exercises like pushups and situps, but also weightlifting and resistance training using bands or workout machines.

When you do strength training, over time, exercises that at first felt difficult become easier as your muscles increase in strength and size a process called hypertrophy. Bigger muscles simply have larger muscle fibers and cells, and this allows you to lift heavier weights. As you keep working out, you can continue to increase the difficulty or weight of the exercises as your muscles get bigger and stronger.

It is easy to see that working out makes muscles bigger, but what is actually happening to the cells as muscles increase in strength and size in response to resistance training?

Any time you move your body, you are doing so by shortening and pulling with your muscles a process called contraction. This is how muscles spend energy to generate force and produce movement. Every time you contract a muscle especially when you have to work hard to do the contraction, like when lifting weights the action causes changes to the levels of various chemicals in your muscles. In addition to the chemical changes, there are also specialized receptors on the surface of muscle cells that detect when you move a muscle, generate force or otherwise alter the biochemical machinery within a muscle.

In a healthy young person, when these chemical and mechanical sensory systems detect muscle movement, they turn on a number of specialized chemical pathways within the muscle. These pathways in turn trigger the production of more proteins that get incorporated into the muscle fibers and cause the muscle to increase in size.

These cellular pathways also turn on genes that code for specific proteins in cells that make up the muscles contracting machinery. This activation of gene expression is a longer-term process, with genes being turned on or off for several hours after a single session of resistance exercise.

The overall effect of these many exercise-induced changes is to cause your muscles to get bigger.

While the basic biology of all people, young or old, is more or less the same, something is behind the lack of senior citizens in professional sports. So what changes in a persons muscles as they age?

What my colleagues and I have found in our research is that in young muscle, a little bit of exercise produces a strong signal for the many processes that trigger muscle growth. In older peoples muscles, by comparison, the signal telling muscles to grow is much weaker for a given amount of exercise. These changes begin to occur when a person reaches around 50 years old and become more pronounced as time goes on.

In a recent study, we wanted to see if the changes in signaling were accompanied by any changes in which genes and how many of them respond to exercise. Using a technique that allowed us to measure changes in thousands of genes in response to resistance exercise, we found that when younger men exercise, there are changes in the expression of more than 150 genes. When we looked at older men, we found changes in the expression of only 42 genes. This difference in gene expression seems to explain, at least partly, the more visible variation between how young and old people respond to strength training.

When you put together all of the various molecular differences in how older adults respond to strength training, the result is that older people do not gain muscle mass as well as young people.

But this reality should not discourage older people from exercising. If anything, it should encourage you to exercise more as you age.

Exercise still remains one of the most important activities older adults can do for their health. The work my colleagues and I have done clearly shows that although the responses to training lessen with age, they are by no means reduced to zero.

We showed that older adults with mobility problems who participate in a regular program of aerobic and resistance exercise can reduce their risk of becoming disabled by about 20%. We also found a similar 20% reduction in risk of becoming disabled among people who are already physically frail if they did the same workout program.

While younger people may get stronger and build bigger muscles much faster than their older counterparts, older people still get incredibly valuable health benefits from exercise, including improved strength, physical function and reduced disability. So the next time you are sweating during a workout session, remember that you are building muscle strength that is vital to maintaining mobility and good health throughout a long life.

This article is republished from The Conversation, a nonprofit, independent news organization bringing you facts and trustworthy analysis to help you make sense of our complex world.If you found it interesting, you could subscribe to our weekly newsletter.

It was written by: Roger Fielding, Tufts University.

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Roger Fielding receives funding from USDA, NIH, Biophytis, Nestle', Lonza.

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50-year-old muscles just can't grow big like they used to the biology of how muscles change with age - Yahoo News

In 2023, big projects create ‘satellite maps’ of cell biology – BioWorld Online

23 in review

If we unraveled the DNA of the 46 chromosomes of a single human cell, it would barely measure 2 meters. If we did the same with the rest of the body, if we aligned the 3 billion base pairs of its 5 trillion cells, we could travel the distance from the Earth to the Sun more than 100 times. It seems unreachable. However, that is the unit of knowledge of the large sequencing projects achieved in 2023. From the generation of the human pangenome to cell-by-cell maps of the brain and kidneys, scientists this year have completed several omics collaborative projects stored in large international databases. Now, whats the plan?

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In 2023, big projects create 'satellite maps' of cell biology - BioWorld Online