Category Archives: Cell Biology

Cell Biology and Molecular Genetics | Biological Sciences …

The MS and PhD programs in Cell Biology and Molecular Genetics seek to provide training in the genetic and molecular basis of disease states. Areas of research within this program include cancer biology, drug discovery, liquid crystals, wound healing, lipid biophysics, cell physiology, cell signaling, and bioinformatics. Students in this program will develop a strong foundation in molecular and cellular biology that can be applied to a research career in academic, government, and industry settings. Students specifically interested in Cell Biology should refer to the Cell Biology Graduate Faculty page and Departmental research pages for more information.

Within this program we offer three research tracks, which are built around our research expertise:

Common Coursework:

Tracks:

Possible Electives:

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Cell Biology and Molecular Genetics | Biological Sciences ...

Faculty and Research: Cell Biology – UT Southwestern …

The Fiolka lab extends the current imaging capabilities of optical microscopy such that cancer cell research and drug screening can be performed in physiologically relevant, 3D environments, ex vivo and in vivo. The microscope development is focused on improving the spatiotemporal resolution and optical penetration depth and translating the new technologies to biological research.

Our laboratory studies the cell biology of viral-host interactions. Our main focus is on the interplay between RNA viruses, such as influenza A and vesicular stomatitis viruses, and nuclear processes. We investigate interactions of virulence factors with RNA processing and nucleo-cytoplasmic trafficking, which regulate viral replication and antiviral response.

Our lab studies the spatial organization of mitochondria. We are focused on elucidating the molecular mechanisms that govern cristae number and placement along the mitochondrial inner membrane. We are especially interested in how the cell dynamically modulates mitochondrial ultrastructure during shifts in metabolic demand, in different tissues, and under stress conditions.

We use fibroblasts interacting with 3D collagen as a model of fibrous connective tissue to learn about cell behavior in a tissue-like environment. Our research focuses on motile and mechanical interactions between cells and matrix. We analyze these interactions at global and subcellular levels to understand the impact of cell-matrix tension state on cell morphology and mechanical behavior.

Our lab studies how cellular membranes are sculpted during processes like vesicle budding, organelle biogenesis, and the formation of inter-organelle membrane contact sites. We employ both budding yeast and mammalian cell systems to reveal molecular mechanisms of this membrane remodeling, and our main projects use combinations of cell biology, genetics, biochemistry, and structural biology to deeply understand cellular sculpting events.

Our laboratory is interested in the molecular mechanisms governing cytokine receptor signal transduction in hematopoietic stem and progenitor cells, and understanding how deregulation in these mechanisms results in hematological malignancies and cancer.

My research focuses on islet biologyand diabetes. Our long term-goal is to uncover mechanisms and processes thatcontribute to the maintenance of islet cell fitness and function.Currentlywe arestudying ZnT8 in islet cells aiming to understand how Slc30a8 haploinsufficiency protectstype 2 diabetes. We are also developing techniques and probes formonitoring islet beta cell mass or function in vitro and invivo.

Our lab studies the role of adaptor proteins on plasma membrane function in the context of endocytosis and cellular signaling.

Our lab studies why cells utilize primary cilia to organize signaling, and how extracellular inputs are spatio-temporally integrated by these compartments. Studying ciliary signaling also provides a more general paradigm for studying cellular sensory networks in regulating developmental pathways, and disease pathologies.

Our lab studies 3D structures and cell biological functions of macromolecular complexes inside cells, such as molecular motors, microtubules in cilia, and cancer-related nuclear proteins.

We study the mechanisms that govern and regulate clathrin-mediated endocytosis using biochemistry, biophysics, molecular cell biology and quantitative live-cell fluorescence microscopy.

We study the molecular mechanisms governing the function and inheritance of complex cellular organelles. In particular, we are investigating how the single Golgi apparatus is partitioned by the spindle machinery in mitosis as well as the regulatory role of the Golgi in organizing polarity during cell migration.

The Shay/Wright Lab studies the role of telomere biology in aging and cancer, the molecular mechanism of telomere replication and telomerase action, and how to translate these into clinical applications.

Our long-term vision is to create a synthetic cell that recapitulates changes in cytoplasmic state in response to fertilization. Additionally, we aim to understand how cell division errors arise that lead to cancer, developmental defects, and age-related infertility.

The Shay/Wright Lab studies the role of telomere biology in aging and cancer, the molecular mechanism of telomere replication and telomerase action, and how to translate these into clinical applications.

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Faculty and Research: Cell Biology - UT Southwestern ...

Cell Biology – 3rd Edition – Elsevier | An Information …

Section 1: Introduction to Cell Biology

1 Introduction to Cells

2 Evolution of Life on Earth

Section 2: Chemical and Physical Background

3 Molecules: Structures and Dynamics

4 Biophysical Principles

5 Macromolecular Assembly

6 Research Strategies

Section 3: Chromatin, Chromosomes, and the Cell Nucleus

7 Chromosome Organization

8 DNA Packaging in Chromatin and Chromosomes

9 Nuclear Structure and Dynamics

Section 4: Central Dogma: From Gene to Protein

10 Gene Expression

11 Eukaryotic RNA Processing

12 Protein Synthesis and Folding

Section 5: Membrane Structure and Function

13 Membrane Structure and Dynamics

14 Membrane Pumps

15 Membrane Carriers

16 Membrane Channels

17 Membrane Physiology

Section 6: Cellular Organelles and Membrane Trafficking

18 Posttranslational Targeting of Proteins

19 Mitochondria, Chloroplasts, Peroxisomes

20 Endoplasmic Reticulum

21 Secretory Membrane System and Golgi Apparatus

22 Endocytosis and the Endosomal Membrane

23 Processing and Degradation of Cellular Components

Section 7: Signaling Mechanisms

24 Plasma Membrane Receptors

25 Protein Hardware for Signaling

26 Second Messengers

27 Integration of Signals

Section 8: Cellular Adhesion and the Extracellular Matrix

28 Cells of the Extracellular Matrix and Immune System

29 Extracellular Matrix Molecules

30 Cellular Adhesion

31 Intercellular Junctions

32 Connective Tissues

Section 9: Cytoskeleton and Cellular Motility

33 Actin and Actin-Binding Proteins

34 Microtubules and Centrosomes

35 Intermediate Filaments

36 Motor Proteins

37 Intracellular Motility

38 Cellular Motility

39 Muscles

Section 10: Cell Cycle

40 Introduction to the Cell Cycle

41 G1 Phase and Regulation of Cell Proliferation

42 S Phase and DNA Replication

43 G2 Phase and Control of Entry into Mitosis

44 Mitosis and Cytokinesis

45 Meiosis

46 Programmed Cell Death

Glossary

Appendix

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Cell Biology - 3rd Edition - Elsevier | An Information ...

Home : Cell Biology

Research Topics

Research Topic #1

Physiology

Physiology is the scientific study of normal mechanisms, and their interactions, which operate within a living system. A sub-discipline of biology, its focus is in how organisms, organ systems, organs, cells, and biomolecules carry out the chemical or physical functions that exist in a living system. Given the size of the field, it is divided into, among others, animal physiology, plant physiology, cellular physiology, microbial physiology, bacterial physiology, and viral physiology.

Research Topic #2

Bioinformatics

Bioinformatics is an interdisciplinary field that develops methods and software tools for understanding biological data. As an interdisciplinary field of science, bioinformatics combines computer science, statistics, mathematics, and engineering to analyze and interpret biological data. Bioinformatics has been used for in silico analyses of biological queries using mathematical and statistical techniques. Bioinformatics is both an umbrella term for the body of biological studies that use computer programming as part of their methodology, as well as a reference to specific analysis "pipelines" that are repeatedly used, particularly in the field of genomics.

Research Topic #3

Developmental biology

Developmental biology is the study of the process by which animals and plants grow and develop. Developmental biology also encompasses the biology of regeneration, asexual reproduction and metamorphosis and in the growth and differentiation of stem cells in the adult organism.

Research Topic #4

Cell biology

Cell biology is a branch of biology that studies the different structures and functions of the cell and focuses mainly on the idea of the cell as the basic unit of life. Cell biology explains the structure, organization of the organelles they contain, their physiological properties, metabolic processes, Signaling pathways, life cycle, and interactions with their environment.

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Home : Cell Biology

SUNY Downstate – Department of Cell Biology

The Department of Cell Biology is a multidisciplinary basic science department in the College of Medicine (COM). Our diverse research portfolio emphasizes the mechanisms of gene expression in health and disease, particularly with respect to lipid metabolism, the cardiovascular system, microbiology, immunology, and organ system development. Joint research projects with clinical departments, such as Ophthalmology (as partners in the SUNY-Eye Instituteand Medicine, focus on cardiovascular disease, diabetes, glaucoma/blindness, epilepsy, autoimmunity, and cancer. Faculty have appointments in the School of Graduate Studiesso as to mentor and train doctoral candidates in the Programs in Molecular and Cellular Biology, Neural and Behavioral Science, and Biomedical Engineering.

Faculty are also medical educators responsible for delivering pre-clinical (Foundation) years trainingin the COM, most notably Gross Anatomy, Histology, and Neuroanatomy. This is reflected in our Gross Anatomy facultys research in the evolution of human anatomical structures and in new modalities for medical education, including the medical educator pathway. In addition, we teach in the College of Health Related Professions, and the College of Nursing.

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SUNY Downstate - Department of Cell Biology

Cell Biology :: Science Publishing Group

Endriyas Kelta Wabalo, Chala Kenenisa Edae

Pages: 33-46Published Online: Jan. 4, 2019

Divine Mensah Sedzro, Sm Faysal Bellah, Hameed Akbar, Sardar Mohammad Saker Billah

Pages: 20-32Published Online: Oct. 29, 2018

Toshikazu Nishimura

Pages: 9-12Published Online: May 5, 2018

Shuhei Soeda, Hideo Taniura

Pages: 13-19Published Online: Aug. 2, 2018

Sheila Maureen Benson, Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, Gopal Nayak, Mayank Gangwar, Snehasis Jana

Pages: 1-8Published Online: Feb. 9, 2018

Mahendra Kumar Trivedi, Alice Branton, Dahryn Trivedi, Gopal Nayak, William Dean Plikerd, Peter L. Surguy, Robert John Kock, Rolando Baptista Piedad, Russell Phillip Callas, Sakina A. Ansari, Sandra Lee Barrett, Sara Friedman, Steven Lee Christie, Su-Mei Chen Liu, Susan Elizabeth Starling, Susan Jones, Susan Mardis Allen, Susanne Kathrin Wasmus, Terry Ann Benczik, Thomas Charles Slade, Thomas Orban, Victoria L. Vannes, Victoria Margot Schlosser, Yusif Sarkis Yamin Albino, Mayank Gangwar, Snehasis Jana

Pages: 66-75Published Online: Dec. 11, 2017

Abida Sultana, Mohammad Nurul Amin, Muhammed Yusuf Miah, Ashish Kumar Sarker, Md. Mahabub Alam Rasel, Mohammad Tarek Aziz, Farzana Sharmin, Md. Abdul Hakim, Hosneara Shiddika, Shajal Hossain Emon, Tanjina Parvin Tuli, Mst Monira Khanom

Pages: 57-65Published Online: Oct. 10, 2017

Elijah Yanda Shaba, Tsado John Mathew, Amos Ndarubu Tsado, Abdulfatai Aiyede Otori, Emaka Ogbonna

Pages: 53-56Published Online: Mar. 30, 2017

Wedad M. Al-Adiwish, Maryam A. S. Abubakr, Naowara M. Alarafi

Pages: 45-52Published Online: Mar. 1, 2017

Dare Babatunde Joseph, Olayemi Olamide Samuel, Falana Benedict Abiola, Duru Francis I. Ogueri, Osinubi Abraham A. A.

Pages: 38-44Published Online: Jul. 18, 2017

Cell Biology (CB), a journal of experimental cell investigation, publishes reviews, original articles and short communications on the structure, function and macromolecular organization of cells and cell components. Contributions focusing on cellular dynamics, motility and differentiation, particularly if related to cellular biochemistry, molecular biology, immunology, neurobiology, and developmental biology are encouraged. Manuscripts describing significant technical advances are also welcome. The topics related to this journal include but are not limited to:

Cell adhesion and motility

Cellular communication

Cell cycle and division

Cell growth, survival, and death

Cell structure and dynamics

Cellular disease mechanisms

Cytoskeleton and molecular motors

Gene expression and RNA metabolism

Methods and techniques

Organelle homeostasis

Protein and membrane trafficking

computational cell biology

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Cell Biology :: Science Publishing Group

Cell – Definition, Functions, Types and Examples | Biology …

Cell Definition

Cells are the basic unit of life. In the modern world, they are the smallest known world that performs all of lifes functions. All living organisms are either single cells, or are multicellular organisms composed of many cells working together.

Cells are the smallest known unit that can accomplish all of these functions. Defining characteristics that allow a cell to perform these functions include:

Below we will discuss the functions that cells must fulfill in order to facilitate life, and how they fulfill these functions.

Scientists define seven functions that must be fulfilled by a living organism. These are:

It is the biology of cells which enables living things to perform all of these functions. Below, we discuss how they make the functions of life possible.

In order to accomplish them, they must have:

The different cell types we will discuss below have different ways of accomplishing these functions.

Because of the millions of diverse species of life on Earth, which grow and change gradually over time, there are countless differences between the countless extant types of cells.

However, here we will look at the two major types of cells, and two important sub-categories of each.

Prokaryotes are the simpler and older of the two major types of cells. Prokaryotes are single-celled organisms. Bacteria and archaebacteria are examples of prokaryotic cells.

Prokaryotic cells have a cell membrane, and one or more layers of additional protection from the outside environment. Many prokaryotes have a cell membrane made of phospholipids, enclosed by a cell wall made of a rigid sugar. The cell wall may be enclosed by another thick capsule made of sugars.

Many prokaryotic cells also have cilia, tails, or other ways in which the cell can control its movement.

Prokaryote cell

These characteristics, as well as the cell wall and capsule, reflect the fact that prokaryotic cells are going it alone in the environment. They are not part of a multicellular organism, which might have whole layers of cells devoted to protecting other cells from the environment, or to creating motion.

Prokaryotic cells have a single chromosome which contains all of the cells essential hereditary material and operating instructions. This single chromosome is usually round. There is no nucleus, or any other internal membranes or organelles. The chromosome just floats in the cells cytoplasm.

Additional genetic traits and information might be contained in other gene units within the cytoplasm, called plasmids, but these are usually genes that are passed back and forth by prokaryotes though the process of horizontal gene transfer, which is when one cell gives genetic material to another. Plasmids contain non-essential DNA that the cell can live without, and which is not necessarily passed on to offspring.

When a prokaryotic cell is ready to reproduce, it makes a copy of its single chromosome. Then the cell splits in half, apportioning one copy of its chromosome and a random assortment of plasmids to each daughter cell.

There are two major types of prokaryotes known to scientists to date: archaebacteria, which are a very old lineage of life with some biochemical differences from bacteria and eukaryotes, and bacteria, sometimes called eubacteria, or true bacteria to differentiate them from archaebacteria.

Bacteria are thought to be more modern descendants of archaebacteria.

Both families have bacteria in the name because the differences between them were not understood prior to the invention of modern biochemical and genetic analysis techniques.

When scientists began to examine the biochemistry and genetics of prokaryotes in detail, they discovered these two very different groups, who probably have different relationships to eukaryotes and different evolutionary histories!

Some scientists think that eukaryotes like humans are more closely related to bacteria, since eukaryotes have similar cell membrane chemistry to bacteria. Others think that archaebacteria are more closely related to us eukaryotes, since they use similar proteins to reproduce their chromosomes.

Still others think that we might be descended from both that eukaryotic cells might have come into existence when archaebacteria started living inside of a bacterial cell, or vice versa! This would explain how we have important genetic and chemical attributes of both, and why we have multiple internal compartments such as the nucleus, chloroplasts, and mitochondria!

Eukaryotic cells are thought to be the most modern major cell type. All multicellular organisms, including you, your cat, and your houseplants, are eukaryotes. Eukaryotic cells seem to have learned to work together to create multicellular organisms, while prokaryotes seem unable to do this.

Eukaryotic cells usually have more than one chromosome, which contains large amounts of genetic information. Within the body of a multicellular organism, different genes within these chromosomes may be switched on and off, allowing for cells that have different traits and perform different functions within the same organism.

Eukaryotic cells also have one or more internal membranes, which has led scientists to the conclusion that eukaryotic cells likely evolved when one or more types of prokaryote began living in symbiotic relationships inside of other cells.

Organelles with interior membranes found in eukaryotic cells typically include:

As mentioned above, archaebacteria are a very old form of prokaryotic cells. Biologists actually put them in their own domain of life, separate from other bacteria.

Key ways in which archaebacteria differ from other bacteria include:

Archaebacterias unique chemical attributes allow them to live in extreme environments, such as superheated water, extremely salty water, and some environments which are toxic to all other life forms.

Scientists became very excited in recent years at the discovery of Lokiarchaeota a type of archaebacteria which shares many genes with eukaryotes that had never before been found in prokaryotic cells!

It is now thought that Lokiarchaeota may be our closest living relative in the prokaryotic world.

You are most likely familiar with the type of bacteria that can make you sick. Indeed, common pathogens like Streptococcus and Staphylococcus are prokaryotic bacterial cells.

But there are also many types of helpful bacteria including those that break down dead waste to turn useless materials into fertile soil, and bacteria that live in our own digestive tract and help us digest food.

Bacterial cells can commonly be found living in symbiotic relationships with multicellular organisms like ourselves, in the soil, and anywhere else thats not too extreme for them to live!

Plant cells are eukaryotic cells that are part of multicellular, photosynthetic organisms.

Plants cells have chloroplast organelles, which contain pigments that absorb photons of light and harvest the energy of those photons.

Chloroplasts have the remarkable ability to turn light energy into cellular fuel, and use this energy to take carbon dioxide from the air and turn it into sugars that can be used by living things as fuel or building material.

In addition to having chloroplasts, plant cells also typically have a cell wall made of a rigid sugars, to enable plant tissues to maintain their upright structures such as leaves, stems, and tree trunks.

Plant cells also have the usual eukaryotic organelles including a nucleus, endoplasmic reticulum, and Golgi apparatus.

For this exercise, lets look at a type of animal cell that is of great importance to you: your own liver cell.

Like all animal cells, it has mitochondria which perform cellular respiration, turning oxygen and sugar into large amounts of ATP to power cellular functions.

It also has the same organelles as most animal cells: a nucleus, endoplasmic reticulum, Golgi apparatus, etc..

But as part of a multicellular organism, your liver cell also expresses unique genes, which give it unique traits and abilities.

Liver cells in particular contain enzymes that break down many toxins, which is what allows the liver to purify your blood and break down dangerous bodily waste.

The liver cell is an excellent example of how multicellular organisms can be more efficient by having different cell types work together.

Your body could not survive without liver cells to break down certain toxins and waste products, but the liver cell itself could not survive without nerve and muscle cells that help you find food, and a digestive tract to break down that food into easily digestible sugars.

And all of these cell types contain the information to make all the other cell types! Its simply a matter of which genes are switched on or off during development.

1. Which of the following is NOT an essential function that all living things must perform?A. A living thing must reproduce.B. A living thing must be able to maintain its internal environment, regardless of external changes.C. A living thing must respond to changes in its environment.D. None of the above.

Answer to Question #1

D is correct. All of the above are essential functions of life!

2. Which of the following is NOT a type of prokaryotic cell?A. ArchaebacteriaB. Staphylococcus bacteriaC. Streptococcus bacteriaD. Liver cell

Answer to Question #2

D is correct. Liver cells are eukaryotic cells, like all cells from multicellular organisms!

3. Which of the following is NOT a eukaryotic cell organelle?A. PlasmidB. NucleusC. MitochondriaD. Chloroplast

Answer to Question #3

B is correct. Plasmids are pieces of DNA that are passed between prokaryotic cells. They are not organelles.

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Cell - Definition, Functions, Types and Examples | Biology ...

Cell Biology – 9780323341264 | US Elsevier Health Bookshop

Section 1: Introduction to Cell Biology

1 Introduction to Cells

2 Evolution of Life on Earth

Section 2: Chemical and Physical Background

3 Molecules: Structures and Dynamics

4 Biophysical Principles

5 Macromolecular Assembly

6 Research Strategies

Section 3: Chromatin, Chromosomes, and the Cell Nucleus

7 Chromosome Organization

8 DNA Packaging in Chromatin and Chromosomes

9 Nuclear Structure and Dynamics

Section 4: Central Dogma: From Gene to Protein

10 Gene Expression

11 Eukaryotic RNA Processing

12 Protein Synthesis and Folding

Section 5: Membrane Structure and Function

13 Membrane Structure and Dynamics

14 Membrane Pumps

15 Membrane Carriers

16 Membrane Channels

17 Membrane Physiology

Section 6: Cellular Organelles and Membrane Trafficking

18 Posttranslational Targeting of Proteins

19 Mitochondria, Chloroplasts, Peroxisomes

20 Endoplasmic Reticulum

21 Secretory Membrane System and Golgi Apparatus

22 Endocytosis and the Endosomal Membrane

23 Processing and Degradation of Cellular Components

Section 7: Signaling Mechanisms

24 Plasma Membrane Receptors

25 Protein Hardware for Signaling

26 Second Messengers

27 Integration of Signals

Section 8: Cellular Adhesion and the Extracellular Matrix

28 Cells of the Extracellular Matrix and Immune System

29 Extracellular Matrix Molecules

30 Cellular Adhesion

31 Intercellular Junctions

32 Connective Tissues

Section 9: Cytoskeleton and Cellular Motility

33 Actin and Actin-Binding Proteins

34 Microtubules and Centrosomes

35 Intermediate Filaments

36 Motor Proteins

37 Intracellular Motility

38 Cellular Motility

39 Muscles

Section 10: Cell Cycle

40 Introduction to the Cell Cycle

41 G1 Phase and Regulation of Cell Proliferation

42 S Phase and DNA Replication

43 G2 Phase and Control of Entry into Mitosis

44 Mitosis and Cytokinesis

45 Meiosis

46 Programmed Cell Death

Glossary

Appendix

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Cell Biology - 9780323341264 | US Elsevier Health Bookshop