Category Archives: Cell Biology

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Cell Biology – About.com Education

Medical Research Images. Credit: Neil Leslie/Ikon Images/Getty Images

Cell biology is the subdiscipline of biology that studies the basic unit of life, the cell. It deals with all aspects of the cell including cell anatomy, cell division (mitosis and meiosis), and cell processes includingcell respiration, and cell death. Cell biology does not stand alone as a discipline but is closely related to other areas of biology such as genetics, molecular biology, and biochemistry.

Based on one of the basic principles of biology, the cell theory, the study of cells would not have been possible without the invention of the microscope. With the advanced microscopes of today, such as the Scanning Electron Microscope and Transmission Electron Microscope, cell biologists are able to obtain detailed images of the smallest of cell structures and organelles.

Significant Events in Cell Biology

There have been several significant events throughout history that have led to the development of the field of cell biology as it exists today. Below are a few of these major events:

Careers in Cell Biology

Study in the field of cell biology can lead to various career paths. Many cell biologists are research scientists who work in industrial or academic laboratories. Other opportunities include:

All living organisms are composed of cells. Some organisms are comprised of cells that number in the trillions. There are two primary types of cells: eukaryotic and prokaryotic cells. Eukaryotic cells have a defined nucleus, while the prokaryotic nucleus is not defined or contained within a membrane. While all organisms are composed of cells, these cells differ among organisms. Some of these differing characteristics include cell structure, size, shape, and organelle content. For example, animal cells, bacterial cells, and plant cells have similarities, but they are also noticeably different. Cells have different methods of reproduction. Some of these methods include: binary fission, mitosis, and meiosis. Cells house an organisms genetic material (DNA), which provides instructions for all cellular activity.

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Cell Biology - About.com Education

The Biology Project: Cell Biology

Cell Membranes Learn that membranes are fluid, with components that move, change, and perform vital physiological roles as they allow cells to communicate with each other and their environment.

Cell Signaling Learn that living organisms constantly receive and interpret signals from their environment. Cells of multi-cellular organisms also receive signals from other cells, including signals for cell division and differentiation.

Studying Cells Introduce yourself to the cell as the fundamental unit of life and the scientific method.

The Cell Cycle & Mitosis Understand the events that occur in the cell cycle and the process of mitosis that divides the duplicated genetic material creating two identical daughter cells.

Meiosis Understand the events that occur in process of meiosis that takes place to produce our gametes.

Prokaryotes, Eukaryotes, & Viruses Learn about the cells that make up all living systems, their organelles, and the differences between living cells and viruses.

The Cytoskeleton Learn that the cytoskeleton acts both a muscle and a skeleton, and is responsible for cell movement, cytokinesis, and the organization of the organelles within the cell.

Overview of Cells including their makup and the differences between animal and plant cells (link courtesy of Carey Konarski)

CELLS Alive! is a highly visual site, where you will find movies and animated illustrations on cell processes, parasites, penicillin and more.

cell.de Online-Service for Cell Biology includes digital media in internet quality and further information for university and high school on cellular and molecular biology. The IWF - Institute for Scientific Film, Gttingen (Germany) prepares educational media about cellular and molecular biology didactically and technically for different media carriers.

C. elegans Movies A visual introduction to C. elegans and its development. This page has links to movies made by C. elegans researchers worldwide.

Biology Mad. This website is mainly aimed for students studying AQA (spec. A) Biology in the UK. It is informative, beautifully designed and easy to use.

http://www.actionbioscience.org is an education resource of the American Institute of Biological Sciences. The site provides peer-reviewed articles by scientists, science educators, and science students. In addition, the web site provides educators with original lessons and other resources to enhance bioscience teaching. Selected articles are translated into Spanish.

biochem4schools, is an online collection of biochemistry resources. With comprehensive reviews and extensive cross-referencing, this site will be an indispensable tool for teachers and students involved in biochemistry at all levels.

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The Biology Project: Cell Biology

Cell Biology Content – CELLS alive

Cell Models- the structure of eukaryotic and prokaryotic cells

How Big is a ... ?- from dust mites to Ebola on the head of a pin

Mitosis- interactive animation of mitotic stages

Meiosis- interactive animation

The Cell Cycle- how mitosis fits into a cell's overall life cycle

Cell CAMS- see cancer cells and bacteria multiplying in real time

Pumping Myocytes- these heart cells got rhythm

Apoptosis- when a cell commits suicide

Quiz on Cell Biology- check your knowledge

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Cell Biology Content - CELLS alive

Biological Cell Introduction – Biology Online

It only takes one biological cell to create an organism. In fact, there are countless species of single celled organisms, and indeed multi-cellular organisms like ourselves.

A single cell is able to keep itself functional by owning a series of 'miniature machines' known as organelles. The following list looks at some of these organelles and other characteristics typical of a fully functioning cell. The italic links for each lead to an extra description in the dictionary, as do all similar links in the tutorials;

Cells can become specialised to perform a particular function within an organism, usually as part of a larger tissue consisting of many of the same cells working in tandem, for example;

Cells combine their efforts in these tissue types to perform a common cause. The task of the specialised cell will determine in what way it is going to be specialised, because different cells are suited to different purposes, as illustrated in the above list and below example;

Many of these cells contain organelles, though after some cells are specialised, they do not possess particular characteristics as they do not require them to be there. i.e. efficiency is the key, no resources are wasted and the resources available are put to their idyllic optimum.

The cell membrane, otherwise known as the plasma membrane is a semi-permeable structure consisting mainly of phospholipid (fat) molecules and proteins. They are structured in a fluid mosaic model, where a double layer of phospholipid molecules provide a barrier accompanied by proteins.

It is present round the circumference of a cell to acts as a barrier, keeping foreign entities out the cell and its contents (like cytoplasm) firmly inside the cell.

The plasma membrane allows only selected materials to pass in and out of a cell, and is thus known as a selectively permeable membrane. There are a number of methods that allow the exchange of materials in and out the cell possible, mentioned below.

There are three methods in which ions are transported through the cell membrane into the cell,

In cells, sometimes it is required to breakdown more complex molecules into more simple molecules, which can then be 're-built' into what is needed by the body with these new raw materials.

'Pinocytosis' where to contents of a structure (such as bacteria) are drank, essentially by breaking down molecules into a drinkable form.

'Phagocytosis' where contents are 'eaten'. See cell defence for more information in regards to this.

Absorption is the uptake of materials from a cells' external environment. Secretion is the ejection of material.

This page is designed to give you an introductory overview of a single cell. The continuing cell biology tutorial elaborates on the concepts mentioned here, and will give you a fuller understanding of the biological cell at work.

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Biological Cell Introduction - Biology Online

Cell biology – Wikipedia, the free encyclopedia

Cell biology (formerly cytology, from the Greek , kytos, "contain") is a branch of biology that studies cells their physiological properties, their structure, the organelles they contain, interactions with their environment, their life cycle, division, death and cell function. This is done both on a microscopic and molecular level. Cell biology research encompasses both the great diversity of single-celled organisms like bacteria and protozoa, as well as the many specialized cells in multicellular organisms such as humans, plants, and sponges.

Knowing the components of cells and how cells work is fundamental to all biological sciences. Appreciating the similarities and differences between cell types is particularly important to the fields of cell and molecular biology as well as to biomedical fields such as cancer research and developmental biology. These fundamental similarities and differences provide a unifying theme, sometimes allowing the principles learned from studying one cell type to be extrapolated and generalized to other cell types. Therefore, research in cell biology is closely related to genetics, biochemistry, molecular biology, immunology, and developmental biology.

Each type of protein is usually sent to a particular part of the cell. An important part of cell biology is the investigation of molecular mechanisms by which proteins are moved to different places inside cells or secreted from cells.

Most proteins are synthesized by ribosomes in the rough endoplasmic reticulum (RER). Ribosomes contain the nucleic acid RNA, which assembles and joins amino acids to make proteins. They can be found alone or in groups within the cytoplasm as well as on the RER. This process is known as protein biosynthesis. Biosynthesis (also called biogenesis) is an enzyme-catalyzed process in cells of living organisms by which substrates are converted to more complex products (also simply known as protein translation). Some proteins, such as those to be incorporated in membranes (known as membrane proteins), are transported into the RER during synthesis. This process can be followed by transportation and processing in the Golgi apparatus. The Golgi apparatus is a large organelle that processes proteins and prepares them for use both inside and outside the cell. The Golgi apparatus is somewhat like a post office. It receives items (proteins from the ER), packages and labels them, and then sends them on to their destinations (to different parts of the cell or to the cell membrane for transport out of the cell).[1] From the Golgi, membrane proteins can move to the plasma membrane, to other sub-cellular compartments, or they can be secreted from the cell. The endoplasmic reticulum (ER) and Golgi can be thought of as the "membrane protein synthesis compartment" and the "membrane protein processing compartment", respectively. There is a semi-constant flux of proteins through these compartments. ER and Golgi-resident proteins associate with other proteins but remain in their respective compartments. Other proteins "flow" through the ER and Golgi to the plasma membrane. Motor proteins transport membrane protein-containing vesicles along cytoskeletal tracks to distant parts of cells such as the axon terminals of neurons.

A notable mode of protein transport occurs through the vesicles discussed above. Vesicles are formed by membrane bulges that pinch off, carrying protein with them to another component, may it be the cell membrane or another organelle. This allows proteins to be moved without having to truly cross a membrane.[2]

Some proteins that are made in the cytoplasm contain structural features that target them for transport into mitochondria or the cell nucleus. Some mitochondrial proteins are made inside mitochondria and are coded for by mitochondrial DNA. In plants, chloroplasts also make some cell proteins.

Extracellular and cell surface proteins destined to be degraded can move back into intracellular compartments upon being incorporated into endocytosed vesicles, some of which fuse with lysosomes where the proteins are broken down to their individual amino acids. The degradation of some membrane proteins begins while still at the cell surface when they are separated by secretases. Proteins that function in the cytoplasm are often degraded by proteasomes.

Cells may be observed under the microscope, using several different techniques; these include optical microscopy, transmission electron microscopy, scanning electron microscopy, fluorescence microscopy, and confocal microscopy.

There are several different methods used in the study of cells:

Purification of cells and their parts Purification may be performed using the following methods:

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Cell biology - Wikipedia, the free encyclopedia

Molecular Expressions Cell Biology: Animal Cell Structure

Animal cells are typical of the eukaryotic cell, enclosed by a plasma membrane and containing a membrane-bound nucleus and organelles. Unlike the eukaryotic cells of plants and fungi, animal cells do not have a cell wall. This feature was lost in the distant past by the single-celled organisms that gave rise to the kingdom Animalia. Most cells, both animal and plant, range in size between 1 and 100 micrometers and are thus visible only with the aid of a microscope.

The lack of a rigid cell wall allowed animals to develop a greater diversity of cell types, tissues, and organs. Specialized cells that formed nerves and musclestissues impossible for plants to evolvegave these organisms mobility. The ability to move about by the use of specialized muscle tissues is a hallmark of the animal world, though a few animals, primarily sponges, do not possess differentiated tissues. Notably, protozoans locomote, but it is only via nonmuscular means, in effect, using cilia, flagella, and pseudopodia.

The animal kingdom is unique among eukaryotic organisms because most animal tissues are bound together in an extracellular matrix by a triple helix of protein known as collagen. Plant and fungal cells are bound together in tissues or aggregations by other molecules, such as pectin. The fact that no other organisms utilize collagen in this manner is one of the indications that all animals arose from a common unicellular ancestor. Bones, shells, spicules, and other hardened structures are formed when the collagen-containing extracellular matrix between animal cells becomes calcified.

Animals are a large and incredibly diverse group of organisms. Making up about three-quarters of the species on Earth, they run the gamut from corals and jellyfish to ants, whales, elephants, and, of course, humans. Being mobile has given animals, which are capable of sensing and responding to their environment, the flexibility to adopt many different modes of feeding, defense, and reproduction. Unlike plants, however, animals are unable to manufacture their own food, and therefore, are always directly or indirectly dependent on plant life.

Most animal cells are diploid, meaning that their chromosomes exist in homologous pairs. Different chromosomal ploidies are also, however, known to occasionally occur. The proliferation of animal cells occurs in a variety of ways. In instances of sexual reproduction, the cellular process of meiosis is first necessary so that haploid daughter cells, or gametes, can be produced. Two haploid cells then fuse to form a diploid zygote, which develops into a new organism as its cells divide and multiply.

The earliest fossil evidence of animals dates from the Vendian Period (650 to 544 million years ago), with coelenterate-type creatures that left traces of their soft bodies in shallow-water sediments. The first mass extinction ended that period, but during the Cambrian Period which followed, an explosion of new forms began the evolutionary radiation that produced most of the major groups, or phyla, known today. Vertebrates (animals with backbones) are not known to have occurred until the early Ordovician Period (505 to 438 million years ago).

Cells were discovered in 1665 by British scientist Robert Hooke who first observed them in his crude (by today's standards) seventeenth century optical microscope. In fact, Hooke coined the term "cell", in a biological context, when he described the microscopic structure of cork like a tiny, bare room or monk's cell. Illustrated in Figure 2 are a pair of fibroblast deer skin cells that have been labeled with fluorescent probes and photographed in the microscope to reveal their internal structure. The nuclei are stained with a red probe, while the Golgi apparatus and microfilament actin network are stained green and blue, respectively. The microscope has been a fundamental tool in the field of cell biology and is often used to observe living cells in culture. Use the links below to obtain more detailed information about the various components that are found in animal cells.

Centrioles - Centrioles are self-replicating organelles made up of nine bundles of microtubules and are found only in animal cells. They appear to help in organizing cell division, but aren't essential to the process.

Cilia and Flagella - For single-celled eukaryotes, cilia and flagella are essential for the locomotion of individual organisms. In multicellular organisms, cilia function to move fluid or materials past an immobile cell as well as moving a cell or group of cells.

Endoplasmic Reticulum - The endoplasmic reticulum is a network of sacs that manufactures, processes, and transports chemical compounds for use inside and outside of the cell. It is connected to the double-layered nuclear envelope, providing a pipeline between the nucleus and the cytoplasm.

Endosomes and Endocytosis - Endosomes are membrane-bound vesicles, formed via a complex family of processes collectively known as endocytosis, and found in the cytoplasm of virtually every animal cell. The basic mechanism of endocytosis is the reverse of what occurs during exocytosis or cellular secretion. It involves the invagination (folding inward) of a cell's plasma membrane to surround macromolecules or other matter diffusing through the extracellular fluid.

Golgi Apparatus - The Golgi apparatus is the distribution and shipping department for the cell's chemical products. It modifies proteins and fats built in the endoplasmic reticulum and prepares them for export to the outside of the cell.

Intermediate Filaments - Intermediate filaments are a very broad class of fibrous proteins that play an important role as both structural and functional elements of the cytoskeleton. Ranging in size from 8 to 12 nanometers, intermediate filaments function as tension-bearing elements to help maintain cell shape and rigidity.

Lysosomes - The main function of these microbodies is digestion. Lysosomes break down cellular waste products and debris from outside the cell into simple compounds, which are transferred to the cytoplasm as new cell-building materials.

Microfilaments - Microfilaments are solid rods made of globular proteins called actin. These filaments are primarily structural in function and are an important component of the cytoskeleton.

Microtubules - These straight, hollow cylinders are found throughout the cytoplasm of all eukaryotic cells (prokaryotes don't have them) and carry out a variety of functions, ranging from transport to structural support.

Mitochondria - Mitochondria are oblong shaped organelles that are found in the cytoplasm of every eukaryotic cell. In the animal cell, they are the main power generators, converting oxygen and nutrients into energy.

Nucleus - The nucleus is a highly specialized organelle that serves as the information processing and administrative center of the cell. This organelle has two major functions: it stores the cell's hereditary material, or DNA, and it coordinates the cell's activities, which include growth, intermediary metabolism, protein synthesis, and reproduction (cell division).

Peroxisomes - Microbodies are a diverse group of organelles that are found in the cytoplasm, roughly spherical and bound by a single membrane. There are several types of microbodies but peroxisomes are the most common.

Plasma Membrane - All living cells have a plasma membrane that encloses their contents. In prokaryotes, the membrane is the inner layer of protection surrounded by a rigid cell wall. Eukaryotic animal cells have only the membrane to contain and protect their contents. These membranes also regulate the passage of molecules in and out of the cells.

Ribosomes - All living cells contain ribosomes, tiny organelles composed of approximately 60 percent RNA and 40 percent protein. In eukaryotes, ribosomes are made of four strands of RNA. In prokaryotes, they consist of three strands of RNA.

In addition the optical and electron microscope, scientists are able to use a number of other techniques to probe the mysteries of the animal cell. Cells can be disassembled by chemical methods and their individual organelles and macromolecules isolated for study. The process of cell fractionation enables the scientist to prepare specific components, the mitochondria for example, in large quantities for investigations of their composition and functions. Using this approach, cell biologists have been able to assign various functions to specific locations within the cell. However, the era of fluorescent proteins has brought microscopy to the forefront of biology by enabling scientists to target living cells with highly localized probes for studies that don't interfere with the delicate balance of life processes.

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Molecular Expressions Cell Biology: Animal Cell Structure

Home | Department of CELL BIOLOGY

Left: Larval muscle (red), neurons (green), & nuclei (blue) in Drosophila cells. Courtesy of A. Sen (Artavanis-Tsakonas Lab). Middle: Membrane protein Climp63 (red) & calreticulin (green) in subdomains of the endoplasmic reticulum. From Shibata et al. Cell (Rapoport Lab). Right: Close-up view of Drosophila larval muscle (red), neurons (green), & nuclei (blue). Courtesy of A. Sen (Artavanis-Tsakonas Lab).

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Biology4Kids.com: Cell Structure – BIOLOGY 4 KIDS.COM

There are smaller pieces that make up cells such as macromolecules and organelles. A protein is an example of a macromolecule while a mitochondrion is an example of an organelle. Cells can also connect to form larger structures. They might group together to form the tissues of the stomach and eventually the entire digestive system. However, in the same way that atoms are the basic unit when you study matter, cells are the basic unit for biology and organisms.

In larger organisms, the main purpose of a cell is to organize. Cells hold a variety of pieces and each cell type has a different purpose. By dividing responsibilities among different groups of cells, it is easier for an organism to survive and grow.

If you were only made of one cell, you would be very limited. You don't find single cells that are as large as a cow. Cells have problems functioning when they get too big. Also, if you were only one cell you couldn't have a nervous system, no muscles for movement, and using the internet would be out of the question. The trillions of cells in your body make your way of life possible.

Plant cells are easier to identify because they have a protective structure called a cell wall made of cellulose. Plants have the wall; animals do not. Plants also have organelles such as the green chloroplast or large, water-filled vacuoles. Chloroplasts are the key structure in the process of photosynthesis.

Humans have hundreds of different cell types. You have red blood cells that are used to carry oxygen (O2) through the body and other cells specific to your heart muscle. Even though cells can be very different, they are basically compartments surrounded by some type of membrane.

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Biology4Kids.com: Cell Structure - BIOLOGY 4 KIDS.COM

Cell – Biology -Online Dictionary

Definition

noun

(Science: Cell Biology)

1. The structural, functional and biological unit of all organisms.

2. An autonomous self-replicating unit that may exist as functional independent unit of life (as in the case of unicellular organism), or as sub-unit in a multicellular organism (such as in plants and animals) that is specialized into carrying out particular functions towards the cause of the organism as a whole.

3. A membrane bound structure containing biomolecules, such as nucleic acids, proteins, and polysaccharides.

Supplement

There are two distinct types of cells: prokaryotic cells (e.g. bacterial cells) and eukaryotic cells (e.g. plant or animal cell). The main difference between the two is a well-defined nucleus surrounded by a membranous nuclear envelope present only in eukaryotic cells. Despite this difference they share a number of common features: the genetic information is stored in genes, proteins serve as their main structural material, ribosomes are used to synthesize proteins, adenosine triphosphate is the main source of metabolic energy to sustain various cellular processes, and a cell membrane that controls the flow of substances into and out of the cell.

Word origin: From Latin cella. Related forms: cellular (adjective) See also: cell biology, cytology, stem cell.

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Cell - Biology -Online Dictionary