Category Archives: Cell Biology

What is Science? A Guide to Understanding Sciencefiction – Breakfast Television Toronto

rogerstestuser | posted Tuesday, May 26th, 2020

Whats Science? Whats Science Fiction?

Science is the study of temperament, of its own processes along with the world, and into it. Its the research of both the natural and synthetic phenomena and so it has physics, chemistry, http://www.hausarbeit-ghostwriter.at/ psychology, psychology, astronomy, meteorology, geology, geophysics, and a lot of other sciences.

What is a Concept in Science? Since we have already established, Science may be the analysis of character and what happens to this and so we want concepts to simply help us understand the world we dwell in. While in the case of scientific tests of a system, we are able to group them into categories, specifically Science, Chemical Science, Biological Science, Quantum Physics, and Space Science.

Although I Bachelorarbeit Ghostwriter Preis prefer to categorize theories as theories in separate and unique ways for each category, there is no set pattern or rule that I can recommend. For example, if one thinks that all the theories are mere opinions with no validity, then that person would be guilty of making a single theory, a Theory in Science.

Theories in Physical Science bargain with laws of character ; they clarify how a world behaves and at which it will go in the future. A-Theory at Physical Science is thought of as a series of predictions about how things may act which will be analyzed through observation.

Newtons concepts were designed from experiments that hed carried out on apples that were diminishing. These experiments are known as Newtons Laws of Motion.

Back in Chemical Science, theories might be categorized as physical, biological, or social/biological and therefore on. Likewise Quantum Physics deals.

Physical Sciences includesPhysiology, Behavior, and Evolution, Chemistry, Metaphysics, Chemistry, Physics, Astronomy, Earth Sciences Aeronautics Marine Biology, Nano Technology, Genetics, Immunology, Cell Biology, Genetics, Pathology, Human Biology. These classes would be the 4 leading branches of the Actual sciences.

Biological Science copes with all living strategies as well as their development, expansion, and reproduction. As an instance, Darwinism explains the evolution of species by means of natural selection notions have been used to study different forms of living.

Social/biological Science concentrates how humans connect solely with also ghostwriting the world and some other people generally. Sociobiology discusses humans impact the environment around them through their own consumption, research, schooling, etc.

Area Science can be involved with the analysis of just how exactly, including the planets, stars, and galaxiesand orbit the center of this Milky Way galaxy. Space Science comprises Planetary Science, Astrophysics, Astronomy, Earth Sciences, Cosmology, Geophysics, and Numerical Arithmetic.

What is Science Fiction? Science fiction is just really a fictionalized interpretation of what may happen inside the universe. Its simply within such a fashion that we are able to test our notions.

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What is Science? A Guide to Understanding Sciencefiction - Breakfast Television Toronto

Cancer Stem Cells Reliance on a Key Amino Acid Could Be an Exploitable Weakness – On Cancer – Memorial Sloan Kettering

By Matthew Tontonoz Tuesday, May 26, 2020

Starving skin cancer tumors of serine increases cancer stem cell differentiation in mice. In this image, skin stem cells undergoing differentiation are magenta and those remaining as stem cells are green.

Summary

A team of scientists at the Sloan Kettering Institute and The Rockefeller University has discovered that cancer stem cells rely on a steady external supply of the amino acid serine. This dependency makes them vulnerable to restrictions on this supply, a discovery that could potentially be exploited therapeutically.

In recent years, cancer biologists have come to understand that metabolism the way that cells acquire and use nutrients can directly affect their tendency to become cancerous.

SKI cell biologist Lydia Finley and colleagues in the Elaine Fuchs lab at The Rockefeller University have now deepened knowledge of this relationship in the context of squamous cell carcinoma, a cancer that arises from stem cells in the skin. Using mouse models and cells growing in tissue culture, they found that the amount of the amino acid serine present in a stem cells environment influences its decision to keep dividing or to grow up (differentiate). Differentiated cells generally do not form cancer.

The stem cells that give rise to squamous cell carcinoma seem to be highly dependent on extracellular serine for their growth, Dr. Finley says. Trying to starve these cells of this source of serine could be a strategy to try to curb their growth by forcing them to differentiate.

A normal stem cell will respond to a shortage of extracellular serine by synthesizing more. Atthe same time, they will begin differentiating: The biochemical pathways involved with serine synthesis interact with proteins called histones that wrap DNA like a spool of thread and allow specific genes to be turned on. Stem cells with cancer-predisposing mutations, on the other hand, seem intent onavoiding new serine synthesis.

Cancer stem cells heightened reliance on extracellular serine reflects what Dr. Finley calls metabolic rewiring: By relying on extracellular serine, the cancer stem cells can avoid serine synthesis, with the happy side effect (for the cancer cell) that the path toward differentiation is blocked.

Our findings link the nutrients that a skin stem cell consumes to their identity and their ability to initiate a tumor, says Sanjeethan Baksh, a Tri-Institutional MD/PhD student in the Fuchs lab and the papers first author. Not only do nutrients allow stem cells and cancer cells to grow, but our study also shows that metabolism directly regulates gene expression programs important for cancer stem cell identity.

Although restricting serine in the diet is not feasible in humans, the team is currently looking for ways that they might be able to interfere with cancer stem cells ability to take up serine in the hope of curbing cancer growth.

The findings were reported on May 25 in the journal Nature Cell Biology.

This study received financial support from the Howard Hughes Medical Institute, the National Institutes of Health (grants R01-AR31737, F31CA236465, F30CA236239-01, and 1F32AR073105), the Human Frontiers Science Program, the European Molecular Biology Organization, NYSTEM (CO29559), The Starr Foundation, the Damon Runyon Cancer Research Foundation, the Concern Foundation, the Anna Fuller Fund, The Edward Mallinckrodt, Jr. Foundation, and the Memorial Sloan Kettering Cancer Center Support Grant P30 CA008748. The study authors declare no competing interests.

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Cancer Stem Cells Reliance on a Key Amino Acid Could Be an Exploitable Weakness - On Cancer - Memorial Sloan Kettering

Alternative Treatment for Mesothelioma in Herb-like Compound – Surviving Mesothelioma

A man-made version of a traditional Chinese herb could be an alternative treatment for mesothelioma.

Turkish researchers have published a new study on a drug called halofuginone. The study shows the drug has significant anticancer effects on mesothelioma cells.

In an article in Cell Biology International, they explore how halofuginone affects mesothelioma and lung cancer cells.

Mesothelioma is an asbestos-linked cancer that is hard to treat. Pleural mesothelioma is the most common type. Pleural mesothelioma grows quickly. It usually causes few symptoms until it is very advanced.

Chemotherapy is the main treatment. When that stops working, many patients look for an alternative treatment for mesothelioma.

Scientists are studying immunotherapy, new kinds of radiotherapy, and even light-based treatments for mesothelioma. So far, there is no reliable second-line alternative treatment for mesothelioma.

Halofuginone is a synthetic molecule. It is an analog of febrifugine. Febrifugine is an alkaloid found in the Chinese herb Dichroa febrifuga (Chang Shan).

In 2015 , Israeli researchers published an article about halofuginone. They wrote, During recent years, halofuginone has attracted much attention because of its wide range of beneficial biological activities, which encompass malaria, cancer, and fibrosis-related and autoimmune diseases.

The Turkish study aimed to understand halofuginones effect on mesothelioma cells. If it limits their growth or causes cell death, it could be an alternative treatment for mesothelioma.

This was the first time for halofuginone tests on malignant mesothelioma cells. Researchers tested the alternative treatment for mesothelioma on lung cancer cells, too.

They found that the drug interrupts the cell cycle. It interferes with signaling proteins. This causes mesothelioma cells to die earlier and at a faster rate. The more halofuginone the researchers used, the more mesothelioma cells died. This was also true for the lung cancer cells.

HF exerts its anti-cancer effects in lung-derived cancers by targeting signal transduction pathwaysto reduce cancer cell viability, induce cell cycle arrest, and apoptotic cell death, writes lead author Asuman Demiroglu-Zergeroglu.

Malignant cells were more susceptible to halofuginone than normal cells.

The research team concludes that halofuginone might be an alternative treatment for mesothelioma. But there have been no US clinical trials on Chinese herbs for mesothelioma.

A British Medical Journal published a review of Chinese clinical trials on herbs in 2013. Most of those studies combined conventional and alternative treatment for mesothelioma.

Source:

Asuman, DZ, et al, Anti-carcinogenic Effects of Halofuginone on Lung Derived Cancer Cells, May 21, 2020, Cell Biology International, Epub ahead of print, https://onlinelibrary.wiley.com/doi/abs/10.1002/cbin.11399

Qihe, X, et al, The quest for modernisation of traditional Chinese medicine, June 13, 2013, BMC Complementatry and Alternative Medicine, pp. 132, https://bmccomplementmedtherapies.biomedcentral.com/articles/10.1186/1472-6882-13-132

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Alternative Treatment for Mesothelioma in Herb-like Compound - Surviving Mesothelioma

New research could be a breakthough in collagen and stem cell research – Truth In Aging

New research has identified two actives that can prevent stem cell decline as we age and increase collagen 17 levels in cells. It was published in Nature last year and has just been covered in Scientific American. The study was described as elegant by a prominent dermatologist, not involved in the project. As I am always on the look out for next big thing in antiaging skincare, I pounced.

Ill cut straight to the car chase. The two actives are Y27632 and apocynin and I was curious to see if they could be tracked down outside of a lab and, perhaps, in our potions and lotions. The first is a chemical that I havent been able to track down. Happily, I had better luck with apocynin.

Apocynin has been identified in a specific strain of cannabis, but also in cloudberry. And rubus chamaemorus (AKA cloudberry) seed oil is in a facial oil by Keracell. Ill post a link at the end of this article.

So, how do Y27632 and apocynin work? Emi Nishimura, a professor of stem cell biology at Tokyo Medical and Dental University in Japan, revealed that aging and UV exposure deplete stem cells of a crucial collagen protein. Heres what happens.

As part of normal skin health, the top layer of the epidermis is constantly being sloughed off and replaced from a self-replenishing pool of stem cells in the basal layer. These stem cells have roots that anchor them to a thin piece of tissue called the basement membrane that connects the epidermis and the dermis. Only when tethered can they replicate and mature into another type of cell.

This is where collagen 17 comes in. This collagen protein does the tethering (see the "adhesive molecule" in the illustration above), rooting the stem cell to the basement membrane. As stem cells become damaged, they lose precious amounts of collagen 17. The more protein they lose, the weaker their bond to the basement membrane, until eventually they are forced out by neighboring healthy cells.

Thats why this study is potentially a breakthrough. It has identified the process, the key protein that needs to be replenished and the chemicals that might just be able to do that.

You can find rubus chamaemorus (AKA cloudberry) seed oil and a potential source of apocynin in KERACELL Liquid Gold Enriching Elixir ($160 in the shop).

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New research could be a breakthough in collagen and stem cell research - Truth In Aging

On the Basis of Gender – The Viking Magazine

Left foot forward. Right foot forward. While that may well be the mantra playing in 18-year-old Caster Semenyas head as she flies furiously down the length of the track towards the finish line, the spectators watching her would be lucky to be able to distinguish between her feet as she runs. Her high speed reduces her muscular figure clad in a South-African-colored uniform to a blur of green and yellow as she finishes almost a full second before her closest opponent at the World Championships in the 800 meter race.

Semenya didnt just win her event she dominated it.

But later that fateful night in 2009, instead of being celebrated for the young phenom that she had trained arduously to become, Semenya came under fire for potentially having an unfair advantage as the public began to question her biological sex. The intrusive testing and inquisitions that followed affected Semenyas ability to compete, but she did her best to hold her head high and carry on as people picked apart her prowess. Semenyas case was just one of many that deals with the complicated role of gender in sports, a topic that becomes increasingly relevant as athletic science improves and athletes of all genders become faster and stronger than ever before.

When people think of sports, their mind often divides mens sports and womens sports into two separate entities, with the athletes within them as strictly binary. Sports have been categorized this way throughout history with the intention of ensuring that competition that ensues will be fair. But how do we define fair, and will this rigid separation continue to be the norm in the future?

In some sports, such as distance swimming, the average percent difference between men and womens times is a slim 5.5%, according to a 2010 study in The Journal of Sports Science and Medicine. In other sports, such as weightlifting, this difference is more significant at 36.8% according to the same source. Because each sport is unique in the physical challenge it presents to athletes, the same standards for legislation and rules regarding gender and fairness cannot be applied universally.

Recently, there has been an increase in discussion surrounding transgender athletes competing in the gender category that best matches their gender identity. While some push back against trans inclusion in situations such as the Idaho bill passed in March that enforces genital and hormonal testing of athletes, others fight for equality in sport. Harvard graduate Schuyler Bailar a trans swimmer who was accepted onto the mens team and found great success and joy in living life as his most authentic self is one of the athletes leading the fight for gender inclusivity in sports. The role that gender plays in sports is already complexthe way gender and sports will interact in the future is even more so.

Despite a social movement towards increased transgender inclusion and a general heightened understanding of what it means to be transgender, many major sports leagues, such as USA Powerlifting, have chosen to keep their original policies in place. In a statement of the organizations transgender participation policy, the USA Powerlifting league cited both the physical advantage of males and a ban on the androgens often used to transition from female to male as reasons for their stance.

While the term discrimination is used to catch the attention of the public, it is most often misused, the statement read. We are a sports organization with rules and policies. They apply to everyone to provide a level playing field.

While some question whether the USA Powerlifting policies are discriminatory against transgender athletes, the organization said it is fair in a sport largely based on physical strength and compared gender discrimination to policies surrounding age restrictions.

This bill attempts to solve a problem that does not exist while slamming the door shut for transgender student athletes to fully participate in their school communities.

Kathy Griesmeyer

At the high school level, some athletes have protested transgender participation in the gender category of their choice. Recently, at a high school in Connecticut, the families of female track runners filed a lawsuit against the participation of transgender athletes in womens sports, arguing that their female children competing against runners with male anatomy could hinder their personal chances of earning track titles and scholarships.

Those who share the same opinion as those parents have formed conservative groups and are supported by legislators throughout the states that are looking to ban participation of transgender athletes in both mens and womens sports. For example, the Idaho state Senate recently passed Republican-sponsored bill 24-11. If signed, this bill would prohibit both trans and intersex girls from competing in the girls heats of high school and college sports.

If a female athletes sex is questioned by a coach, parent, or administration of the other team, the future of that athletes participation depends on if their biological sex is confirmed by a signed physicians statement that shall indicate the students sex based solely on: The students internal and external reproductive anatomy; the students normal endogenously produced levels of testosterone; an analysis of the studentsgenetic makeup, according to the bill.

This bill fails to acknowledge that the inclusion and acceptance of transgender people and their identity is extremely important to their well being, both physically and mentally. By reducing someone to their biological sex characteristics, one is blatantly disregarding their internal identity.

Additionally, this bill only targets female athletes, requiring them to go the extra step if their sex status is questioned in order to play their sport, while their male counterparts do not have to endure this same burden. This suggests that, should a woman have success in an athletic event, her success may be attributed to genetic alterations rather than talent.

Kathy Griesmyer, a policy director with the American Civil Liberties Union of Idaho, is disappointed with this bill, citing that it is intentionally transphobic and that it makes things more difficult for athletes that already face many social hurdles simply for fulfilling their true sense of identity.

This bill attempts to solve a problem that does not exist while slamming the door shut for transgender student athletes to fully participate in their school communities, Griesmyer said in a statement in response to the bill. Idaho has not seen any issues with trans girls competing in the girls sports. This unconstitutional and mean-spirited bill prevents trans girls from finding community and self-esteem in sports, and will certainly result in litigation to defend the civil rights of Idahos transgender community.

In addition to being transphobic, this bill is an invasion of the athletes privacy and puts power in the hands of coaches or parents who may use it to place their competitors at a harsh disadvantage.

In a similar proposition, legislation announced in January could prevent transgender women in Arizona from participating in athletics teams based on their gender identity, requiring some females athletes to provide a doctors note stating their biological sex in order for them to compete in their sport.

However, this rule only applies to womens sport and not to male counterpart sports. The vast majority of the arguments surrounding barring transitioned athletes center solely on male-to-female athletes. Those critics cite the biological differences between men and women that, they claim, could lead to significant competitive advantages for male athletes. Most of these changes take place during puberty: a biological male undergoing puberty will see a host of changes due to their significantly elevated testosterone levels compared with biological females. According to a study comparing female to male testosterone, an adult male will have seven to eight times the natural testosterone coursing through a womans body on average.

This testosterone is accompanied by scores of physiological changes, among them larger muscles, denser bones and a higher proportion of lean body massits these traits that lead to the bigger, faster, stronger notion surrounding male athletes.

While transitioning to female often involves the use of testosterone suppressants and estrogen, most in favor of barring trans athletes argue that these measures dont reverse the increased bone density, superior musculature, and other characteristics of male puberty.

So despite the fact that female-to-male athletes who choose to undergo hormone therapy treatment will also have elevated testosterone levels, this isnt seen as a threat: the vast majority of benefits will be derived from a biological male puberty, not from an addition of testosterone to a body thats undergone female puberty.

But, of course, thats not always the case. A 2016 Washington Post article examining the trans advantage cites that after a year of hormone therapy, female trans distance runners completely lose their speed advantage over cisgender women. Similarly, individuals like Nancy Barto, an Arizona state representative, recognize that regardless of whether a male-to-female athlete will have a greater advantage in sports than a female-to-male athlete, legislature that targets women specifically cis or otherwise puts up barriers to prevent their participation. This type of legislature in sport is counterproductive, introducing yet another in a long line of historical roadblocks for female athletes.

When this is allowed, it discourages female participation in athletics and, worse, it can result in women and girls being denied crucial educational and financial opportunities, Barto said in an interview with NBC News.

The recent passage of such legislation such as the bill signed by Idahos governor on March 30 raises questions about what, exactly, constitutes someone as being transgender. Legislators such as Representative Barbara Ehardt, a sponsor of the bill passed in Idaho, have said that genital exams and genetic and hormone testing could easily determine an athletes sex. However, in reality, sex testing may not be that simple, as it is difficult to come up with metrics to objectively distinguish between different sexes.

Some of the sex testing methods that Ehardt cited may even produce contradictory results. At the 1966 European Track and Field Championships in Budapest, Polish sprinter Ewa Kobukowska passed a genital exam and qualified as female. The following year, Kobukowska failed a chromosomal test, and was barred from participating in the European Cup womens track and field competition in Kiev. An analysis later found that she had a set of XXY chromosomes.

A similar issue arises when it comes to hormone testing. The International Association of Athletics Federation, which sets testosterone limits for women in racing events ranging from the 400-meter to one-mile race, bans athletes who produce abnormally-high levels of testosterone from participating in womens sports.

In 2011, the IAAF set the limit for womens testosterone levels at 10 nanomoles per liter of blood, widely considered the lower end of the typical testosterone level among males. This limit barred Dutee Chand, an Indian sprinter who naturally produces high levels of testosterone, from competition. Chand later won an appeal against her ban; the court agreed with Chand that there was no scientific evidence linking high testosterone levels to better athletic performance. The IAAF commissioned a study in 2017 and justified with data that was highly scrutinized lowered the limit to five nanomoles per liter seven years later, a change that was meant to ensure a level playing field for athletes, IAAF President Sebastian Coe said. Critics argued that the data was flawed, and urged the IAAF to retract the study, which was published in the British Journal of Sports Medicine.

However, the IAAF stood firmly behind its study and said it would not retract the paper. Our evidence and data show that testosterone, either naturally produced or artificially inserted into the body, provides significant performance advantages in female athletes, Coe said. The press release goes on to state that most females have testosterone levels of between 0.12 to 1.79 nanomoles per liter, and that no females testosterone level would exceed the IAAFs new limit unless they had disorders of sex development or a tumor.

An example of a female athlete with higher than usual levels of testosterone is track champion Caster Semenya of South Africa. She began running seriously at age 12, and by the time she became an adult, she was competing in the Olympics. Due to her incredible success and ability, suspicion arose regarding Semenyas biological sex and levels of testosterone. She soon found herself the target of an extremely intrusive media investigation and was eventually barred from competing; after an investigation discovered that she was born with XY chromosomes, Semenyas genetic makeup was ruled an unfair advantage over her competition.

On August 19, 2009, Semenya won the 800-meter event in the World Championship by a landslide, but following this impressive feat came a seemingly never ending public investigation into her biological sex and sex characteristics.

Along with stripping Semenya of any type of celebration or praise for her accomplishments, the public reduced her feats to her gender. The scrutiny Semenya endured is disproportionate to her situation, as she is seconds off the world record and is relatively competitive with other female athletes, disproving the idea that she has an unfair advantage she is simply talented at what she does.

Typically, it is women who endure accusations of this nature. Michael Phelpss abnormally long wingspan is never labeled as an unfair advantage; it is simply a tool that makes him successful. Most professional basketball players are extremely tall compared to the general population, making them genetic oddities, and this is never labeled as an unfair advantage. Yao Ming, for instance, is a staggering 76 tall, a height thats inspired countless conspiracy theories about whether the star was bred in a lab rather than born to his 63 mother and 67 father. Tinfoil hats aside, Mings height enabled him to tower over even his fellow NBA competitors. Ming is nearly a full foot taller than the average NBA player, who stands at 67, and nearly two feet taller than the average American male, who stands at 59, which gives him a clear competitive advantage based on his genetics. And instead of protesting Usain Bolt, society hails him as the fastest man in the world, despite his body being described as built for speed due to his abnormal proportions. In a BBC News article, former Great Britain sprinter Craig Pickering said, Bolt is a genetic freak because being 65 tall means he shouldnt be able to do what he does at the speed he does given the length of his legs.

Along with stripping Semenya of any type of celebration or praise for her accomplishments, the public reduced her to her gender.

The main goal of most professional athletes is to be the best they can, so why was Semenya punished for her gift? The examples listed above are few compared to the gifted male athletes celebrated for the genetic gifts that enable them to compete leaps and bounds ahead of most athletes. And the countless examples seem to point to one central notion: men who are good at what they do are not held to the same unreasonable standards or stigma as their female counterparts.

Although Semenyas case has gained notoriety, she is not the first female athlete to face restrictions from her sport when her performances were deemed, essentially, too good to be true. Maria Jos Martnez-Patio, an internationally-recognized hurdler turned college professor, has a history that eerily parallels that of Semenya, so much so that Martnez-Patio calls herself the Semenya of the 1980s, according to a profile with the United Kingdoms Times. Martnez-Patio faced little scrutiny or public attention initially; at 22, she was given a certificate of femininity after passing a sex test the title is often awarded after enduring humiliating and intrusive tests such as gynecological exams, MRIs, and ultrasounds enabling her to advance to the quarter finals of the 100-meter hurdles at the world championships in Helsinki.

But in 1985, her troubles began.

At the World University Games, a new test karyotype analysis that examined her chromosomes directly found that she had an XY 46th chromosome, the chromosomal pattern typical of a biological male. Martnez-Patios story was more complex than her chromosomes she has androgen insensitivity syndrome which means her body doesnt respond to testosterone in a typical fashion, so any advantage she was perceived to have was likely naturally negated but the storm of public backlash that poured down on her was indifferent to that fact. After her test, Martnez-Patio was ruled ineligible to participate in femaleathletics, and even encouraged to fake an injury to leave quietly. She suddenly found herself barred from the sport shed played and loved all her life and newly privy to information regarding her sex that would leave anyones head spinning if not reconsidering what theyd thought was the truth about their gender their entire life. If the sudden onslaught that had struck Martnez-Patio wasnt already enough, the humiliation and shame of being pushed to lie, to leave gracefully not to make a scene was the final straw. Despite her initial compliance with the injury scheme, Martnez-Patio chose to fight back. In 1986, despite the public media skewering shed endured, she entered the Spanish national championships 60-meter hurdles event. She was told she had two options: withdraw from the event discreetly, or face public condemnation. She chose the latter. After competing and winning, she was stripped of her scholarship and athletic residency, and faced consequences in her private life that were far more hurtful than any Spanish press article.

In The Times article, Martnez-Patio describes how she suffered after the test. I lost my boyfriend because all the media said I was a man, Martnez-Patio said. On many occasions, I thought the best thing was to die because I could not stand so much suffering and injustice. I had to leave my residence in a high-performance center in Madrid within 24 hours. I was on the street. The most complicated thing is having to publicly demonstrate your status as a woman before the whole world. You feel as if everyone is talking about the amount of woman that you are. And this stigma accompanies you for the rest of your life.

Similarly to Martnez-Patios situation, when she was told to cease competing until her chromosomal test results were returned, the International Amateur Athletic Federation, or IAAF, requested Semenya to refrain from competing until there was a definitive conclusion from sex verification tests. As this all occurred, Semenya, her family and her team upheld the statement that she was biologically female and had identified as a woman since birth, regardless of her abnormal hormone levels.

However, this type of testing is not as accurate or conclusive as many hoped it would be. According to many studies and Dr. Gerald Conway, an endocrinologist who worked on the study of Semenyas hormones, while it is true that higher-than-usual levels of testosterone can give an individual an advantage in sport, this is not always the case.

There is an advantage to exposure to testosterone, which is why people use testosterone as an anabolic steroid, Conway said. There are natural conditions, where women normally have more testosterone in circulation, and they would have a biological advantage in many sports arenas.

But the quantitative level of testosterone in ones blood isnt the end all be all, as some women do not react to having high levels of the hormone because their bodies simply dont recognize it.

Katrina Karkazis, a cultural anthropologist and research fellow at Yale, co-authored the book Testosterone: An Unauthorised Biography with Rebecca Jordan-Young, a sociomedical scientist. In it, Karkazis and Jordan-Young critique and dismantle the previously believed effects testosterone has on the body.

In an interview with The Guardian, Karkazis discussed misconceptions about the actual impact testosterone can have on an athlete.

Testosterone is a very dynamic hormone, Karkazis said. Its actually responsive to social cues and situations. For example, if a coach gives you positive feedback, that can raise your testosterone level Where we run into trouble is trying to make comparisons across individuals based on testosterone levels. Sometimes its individuals with lower testosterone who do better. So its not as simple as saying more testosterone equals better performance.

Schuyler Bailar made history as the first openly transgender swimmer in the NCAA. As a member of the graduating class of 2019 from Harvard, the Virginia native took a gap year after high school during which he came out as transgender. After becoming a star swimmer in high school, Bailar had been recruited to swim for the womens team at Harvard, although after coming out he was unsure if he would be able to swim on the mens team once his education at Harvard began.

In an interview on the Ellen Show, Bailar said that while he has not been as competitive in mens heats in comparison to the dominance he showed when racing against women, he doesnt mind. Bailar admits that while he is no longer placing first, he is holding his own in races, defying people who support barring trans athletes from existing as themselves.

Im not winning anything, but I think Im not awful, Bailar said with a smile on his face. I keep up with my teammates and I keep up with the people around me, but Im not winning anything like I used to and thats definitely humbling.

While some people may argue that trans athletes fight to change which gender category they compete in for an advantage or other external reasons, Bailar is simply living life in a way that feels true to himself and because the sport is important to him. Along with being a swimmer, Bailar has become a public speaker, and aims to raise awareness about transgender youth in sports.

It [not winning] has helped me develop something I was working on before, which was learning to love swimming just for swimming, and I think that theres a lot of other kinds of glory in that, Bailar said.

I was just ecstatic and it was as much glory as I wouldve gotten in first place. Probably more, because I was myself.

Schuyler Bailar

Bailar has found that having the support of his team and improving on his own personal times can be just as exciting and rewarding as a medal.

In my last meet, I got sixteenth place, which obviously is not first place, Bailar said with a laugh. But the whole team was on the side of the deck and they jumped up and were screaming for me because I dropped a lot of time from my best, so I did really well relative to myself, and I was just ecstatic and it was as much glory as I wouldve gotten in first place. Probably more, because I was myself.

Elizabeth Edwards, an 18-year-old senior at the Urban School of San Francisco and a transgender woman, believes legislation which requires sex testing doesnt work and unfairly discriminates against transgender women like herself.

The requirement of gender reassignment surgery is ridiculous, especially considering the absurdly strict medical standards currently held in the US to qualify trans people to undergo them, Edwards said. Also, sex verification standards leads without fail to unfair standards of gender expression normativity that bear down on cis people, and result in cis people being disqualified on bases of uniquely high/low chemical levels that result from normal variance in such factors across the cisgender population.

A study conducted by researchers from the Department of Molecular and Cell Biology and Biochemistry at Brown University found that as many as 2% of the population have traits which deviate from the ideal male or female, including hormone levels and the structure of the internal genital duct systems and external genitalia. This seems to suggest that sex testing would not necessarily be as straightforward as critics suggest.

According to Edwards, at the professional level, the highest reasonable requirement should be proof that an athlete has undergone hormone reduction therapy for 18 months.

By that point, trans and cis people are chemically identical, and such quote-unquote biological dis/advantages such as bone density will have fallen to the wayside, Edwards said.

While research on this subject has hardly reached a consensus, a meta-analysis of eight research articles conducted by researchers from the Nottingham Centre for Gender Dysphoria and Loughborough University concluded that there is no evidence that hormones such as testosterone give transgender female athletes an advantage.

The analysis also reviewed 31 sport policies from various national and international competitions and found that rules restricting participation from transgender athletes discourage transgender athletes from participating in sports.

Within competitive sport, the athletic advantage transgender athletes are perceived to have appears to have been overinterpreted by many sport organisations around the world, which has had a negative effect on the experiences of this population, the analysis reads.

The researchers also write that sports organizations need to improve their policies to be more inclusive.

Given the established mental and physical health benefits of engaging in physical activity and sport, the barriers transgender people experience are a significant limitation to the promotion of healthy behaviours in transgender individuals, the analysis reads.

Kay Svenson, a Paly alum and recent graduate of Wellesley college, is a trans activist and believes that trans people, like all people, have the right to be treated in accordance with their gender identity, and this includes sports.

Sex-based discrimination is prohibited under Title IX, and that amendment is not up to the free interpretation of the (potentially transphobic) governing bodies of the state or local school district, Svenson said. We need to work harder to ensure that differences in birth anatomy do not shape our definition of athletic fairness.

Svenson believes that it is important that transgender people have the means and support to pursue their personal athletic careers, free of judgment.

Trans athletes have just as much of a right as cis athletes do to compete in the gender category that they identify with, Svenson said.

While there is no explicitly correct answer or proposed set of regulations surrounding the role of gender identity in sports today, if athletes and fans alike continue to ask hard questions respectfully and work towards giving everyone the opportunities to enjoy sports, compete as themselves, and make sure matches remains competitive, it will be a victory for everyone. Nonetheless, as gender identity and societal views surrounding the gender spectrum become more well understood and all-encompassing, the issues described will only become more complex. Its time to have conversations about this topic now so were ready for the more complex questions later.

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On the Basis of Gender - The Viking Magazine

DNA May Not Be the Blueprint for Life Just a Scrambled List of Ingredients – SciTechDaily

DNA may not be lifes instruction book, but just a jumbled list of ingredients.

University of Maryland researcher develops potentially revolutionary framework for heredity and evolution in which inheritable information is stored outside the genome.

The common view of heredity is that all information passed down from one generation to the next is stored in an organisms DNA. But Antony Jose, associate professor of cell biology and molecular genetics at the University of Maryland, disagrees.

In two new papers, Jose argues that DNA is just the ingredient list, not the set of instructions used to build and maintain a living organism. The instructions, he says, are much more complicated, and theyre stored in the molecules that regulate a cells DNA and other functioning systems.

Jose outlined a new theoretical framework for heredity, which was developed through 20 years of research on genetics and epigenetics, in peer-reviewed papers in the Journal of the Royal Society Interface and the journal BioEssays. Both papers were published on April 22, 2020.

Joses argument suggests that scientists may be overlooking important avenues for studying and treating hereditary diseases, and current beliefs about evolution may be overly focused on the role of the genome, which contains all of an organisms DNA.

DNA cannot be seen as the blueprint for life, Jose said. It is at best an overlapping and potentially scrambled list of ingredients that is used differently by different cells at different times.

For example, the gene for eye color exists in every cell of the body, but the process that produces the protein for eye color only occurs during a specific stage of development and only in the cells that constitute the colored portion of the eyes. That information is not stored in the DNA.

In addition, scientists are unable to determine the complex shape of an organ such as an eye, or that a creature will have eyes at all, by reading the creatures DNA. These fundamental aspects of anatomy are dictated by something outside of the DNA.

Jose argues that these aspects of development, which enable a fertilized egg to grow from a single cell into a complex organism, must be seen as an integral part of heredity. Joses new framework recasts heredity as a complex, networked information system in which all the regulatory molecules that help the cell to function can constitute a store of hereditary information.

Michael Levin, a professor of biology and director of the Tufts Center for Regenerative and Developmental Biology and the Allen Discovery Center at Tufts University, believes Joses approach could help answer many questions not addressed by the current genome-centric view of biology. Levin was not involved with either of the published papers.

Understanding the transmission, storage and encoding of biological information is a critical goal, not only for basic science but also for transformative advances in regenerative medicine, Levin said. In these two papers, Antony Jose masterfully applies a computer science approach to provide an overview and a quantitative analysis of possible molecular dynamics that could serve as a medium for heritable information.

Jose proposes that instructions not coded in the DNA are contained in the arrangement of the molecules within cells and their interactions with one another. This arrangement of molecules is preserved and passed down from one generation to the next.

In his papers, Joses framework recasts inheritance as the combined effects of three components: entities, sensors and properties.

Entities include the genome and all the other molecules within a cell that are needed to build an organism. Entities can change over time, but they are recreated with their original structure, arrangement and interactions at the start of each generation.

That aspect of heredity, that the arrangement of molecules is similar across generations, is deeply underappreciated, and it leads to all sorts of misunderstandings of how heredity works, Jose said.

Sensors are specific entities that interact with and respond to other entities or to their environment. Sensors respond to certain properties, such as the arrangement of a molecule, its concentration in the cell or its proximity to another molecule.

Together, entities, sensors and properties enable a living organism to sense or know things about itself and its environment. Some of this knowledge is used along with the genome in every generation to build an organism.

This framework is built on years of experimental research in many labs, including ours, on epigenetics and multi-generational gene silencing combined with our growing interest in theoretical biology, Jose said. Given how two people who contract the same disease do not necessarily show the same symptoms, we really need to understand all the places where two people can be differentnot just their genomes.

The folly of maintaining a genome-centric view of heredity, according to Jose, is that scientists may be missing opportunities to combat heritable diseases and to understand the secrets of evolution.

In medicine, for instance, research into why hereditary diseases affect individuals differently focuses on genetic differences and on chemical or physical differences in entities. But this new framework suggests researchers should be looking for non-genetic differences in the cells of individuals with hereditary diseases, such as the arrangement of molecules and their interactions. Scientists dont currently have methods to measure some of these things, so this work points to potentially important new avenues for research.

In evolution, Joses framework suggests that organisms could evolve through changes in the arrangement of molecules without changes in their DNA sequence. And in conservation science, this work suggests that attempts to preserve endangered species through DNA banks alone are missing critical information stored in non-DNA molecules.

Jose acknowledged that there will be much debate about these ideas, and experiments are needed to test his hypotheses. But, he said, preliminary feedback from scientists like Levin and other colleagues has been positive.

Antony Joses generalization of memory and encoding via the entity-sensor-property framework sheds novel insights into evolution and biological complexity and suggests important revisions to existing paradigms in genetics, epigenetics and development, Levin said.

###

References:

A framework for parsing heritable information by Antony M. Jose, 22 April 2020, Journal of the Royal Society Interface.DOI: 10.1098/rsif.2020.0154

Heritable Epigenetic Changes Alter Transgenerational Waveforms Maintained by Cycling Stores of Information by Antony M. Jose, 22 April 2020, BioEssays.DOI: 10.1002/bies.201900254

Research in Antony Joses laboratory is supported by the National Institutes of Health (Award Nos. R01GM111457 and R01GM124356). The content of this article does not necessarily reflect the view of this organization.

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DNA May Not Be the Blueprint for Life Just a Scrambled List of Ingredients - SciTechDaily

Watch Out Why Life Science Reagent Market Thriving Worldwide over the Forecasted Period 2020-2027 | Trends, Scope, Segmentation, Competitors Analysis,…

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Nikon Instruments Announces Judging Panel For The 46th Nikon Small World Competition – PRNewswire

Dylan Burnette, Ph.D., Assistant Professor of Cell and Developmental Biology at Vanderbilt University, Christophe Leterrier, Ph.D., group leader at CNRS and Aix-Marseille University, Samantha Clarke, Photo Editor at National Geographic, Sean Greene, Data and Science journalist at The Los Angeles Times, and Ariel Waldman, Antarctic explorer and NASA advisor will make up the 2020 judging panel choosing this year's winning imagery.

For 46 years, Nikon Small World has been recognized as a leading forum to celebrate excellency in microscopy in the form of photos and videos. The competition will honor the top 20 photography and top 5 video winners in addition to awarding Honorable Mentions and Images of Distinction. Winning submissions will be recognized for their exceptional ability to capture visually stunning and scientifically significant moments under the microscope. To celebrate the 10th anniversary of Nikon Small World in Motion, this year's top prize winners of both the video and photo competitions will receive a trip to Japan for themselves and a loved one in addition to the yearly cash prize.

From its beginning, Nikon Small World has aimed to share science, the unseen world, and artistic accomplishments in a vast range of scientific and artistic disciplines with the public at large. Recent past winners have ranged from a turtle embryo to flowers, to frozen water, amino acids, and espresso beans.

The meticulously selected expert judging panel are instrumental in selecting the images and videos that best blend science and artistry. Meet this year's panel:

"Nikon Small World strives to educate, entertain, and share stunning visuals and scientific discoveries with the world at large," said Eric Flem, Communications Manager at Nikon Instruments. "While this year is no doubt different because we are judging remotely, we're excited to come together with an impressive panel of judges whose expertise in art, science, and visualizations will guide us in picking the best microscopy the science community has to offer."

The Nikon Small World in Motion video winners and the winners of the Small World photomicrography competition will be released in the Fall.

For additional information, please visit http://www.nikonsmallworld.com. To get an inside look at the judging process and experience, follow the hashtag #NikonSmallWorld and conversation on Facebook, Twitter (@NikonSmallWorld) and Instagram (@nikoninstruments).

About Nikon Small World Photomicrography CompetitionThe Nikon Small World Photomicrography Competition is open to anyone with an interest in photography or video. Participants may get details and upload digital images and videos directly at http://www.nikonsmallworld.com. For additional information, contact Nikon Small World, Nikon Instruments Inc., 1300 Walt Whitman Road, Melville, NY 11747, USA, or email us at [emailprotected]

About Nikon Instruments Inc. Nikon Instruments Inc. is the US microscopy arm of Nikon Healthcare, a world leader in the development and manufacture of optical and digital imaging technology for biomedical applications. For more information, visit https://www.microscope.healthcare.nikon.com/ or contact us at 1-800-52-NIKON.

SOURCE Nikon Instruments Inc.

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Nikon Instruments Announces Judging Panel For The 46th Nikon Small World Competition - PRNewswire

Lab Mice Shed Fat and Build Muscle with Gene Therapy – The Great Courses Daily News

By Jonny Lupsha, News Writer

According to the Fierce Biotech article, the mice who underwent the new gene therapy were injected with a gene that makes the protein follistatin, which in turn blocks a protein called myostatin. Myostatin regulates muscle growth. The therapy caused a significant buildup of muscle mass in the mice while also preventing obesity, the article said. The mice didnt just build muscle; they also nearly doubled their strength without exercising any more than they usually did. Despite being fed a high-fat diet, they had fewer metabolic issues and stronger hearts than did animals that did not receive the follistatin gene.

Scientists have been developing gene therapy for many years. It can change our bodies in many ways, and has potential serving as a treatment for cancer and muscular dystrophy.

The procedure that the mice underwent encapsulates what gene therapy isalthough scientists generally focus on people.

I define [gene therapy] as the addition of genes to humans for medical purposes, said Dr. David Sadava, Adjunct Professor of Cancer Cell Biology at the City of Hope Medical Center.

Dr. Sadava said gene therapy is based on four assumptions. First, whoever is doing the gene therapy has to know the gene thats involved in whichever problem needs to be treated. Second, they must have a normal, healthy copy of that gene available in the lab. Third, they must know where and when the gene is normally expressed. Finally, they have to be fairly certain what will happen when the gene is expressed normally.

Additionally, gene therapy must do several things in order to be considered successful.

First, gene therapy must get the gene into the appropriate cells, Dr. Sadava said. Second, gene therapy must get the gene expressed in those cells. Third, we have to get the gene integrated into the genome of the target cells so itll be there permanently. And fourth, you better not have any bad side effects to gene therapy, like any therapy in medicine.

According to Dr. Sadava, one kind of gene therapy is referred to as gene augmentation, and it comes into play when the functional product of a gene has been lost and no longer gets produced normally. By injecting a gene into someone, healthy copies of a protein product will be made and function restored.

We could hypothetically think of muscular dystrophy as a good target for gene therapy, he said. We know that muscles lack the protein dystrophinits an organizing proteinso well put in the good gene for good dystrophin.

Another kind of gene therapy is called target cell killing. Dr. Sadava said it uses a gene that either produces a poison that kills certain types of cells or it stimulates the immune system to do so. Target cell killing can be applied to cancer.

A gene is put into cancer cells that allows them to produce a protein that will make a toxic drug from a harmless chemical, Dr. Sadava said. So the idea is we inject a harmless chemical into the body, it goes all over the body and when it enters a tumor cell, its converted into a poison by the gene product of the gene that weve put in for gene therapy. So we might put in a gene that will cause a protein to be made that attracts killer T cells so the tumor will stick up its hand and say Come kill me now.'

Gene therapy is an exciting field in science and medicine with a lot of potential for humans. For now, it may seem like its just helping some overweight mice get a confidence boost, but the practical applications should shore up within our lifetime.

Dr. David Sadava contributed to this article. Dr. Sadava is Adjunct Professor of Cancer Cell Biology at the City of Hope Medical Center in Duarte, CA, and the Pritzker Family Foundation Professor of Biology, Emeritus, at The Claremont Colleges. Professor Sadava graduated from Carleton University with a B.S. with first-class honors in biology and chemistry. He earned a Ph.D. in Biology from the University of California, San Diego.

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Lab Mice Shed Fat and Build Muscle with Gene Therapy - The Great Courses Daily News

Distribution of human tumor mutations more similar to that of chimpanzees, gorillas – News-Medical.net

Reviewed by Emily Henderson, B.Sc.May 21 2020

A new study by researchers from the Institute of Evolutionary Biology (IBE), a joint center of UPF and the Spanish National Research Council (CSIC), shows that, surprisingly, the distribution of mutations in human tumors is more similar to that of chimpanzees and gorillas than that of humans.

The article, which analyses cancer from the evolutionary point of view, is published today, 19 May, in Nature Communications. It was led by Arcadi Navarro and David Juan and involved the researchers Txema Heredia-Genestar and Toms Marqus-Bonet.

Mutations are changes that occur in DNA. They are not distributed throughout the genome evenly, but some regions accumulate more and others less. Although mutations are common in healthy human cells, cancer cells display a greater number of genetic changes. During the development of cancer, tumors rapidly accumulate a large number of mutations. In previous studies, however, it had been observed that surprisingly tumors accumulate mutations in very different regions of the genome from those normally observed in humans.

Now, thanks to the data from the project PanCancer, a research team from the IBE has compared the regions of the genome that accumulate more and less mutations in tumor processes, in the recent history of the human population, and in the history of other primates. The results of this new study reveal that the distribution of mutations in tumors is more like that in chimpanzees and gorillas than in humans.

To date, it was thought that the genetic differences we find when we compare tumors and healthy humans could be caused by the 'abnormal' way tumors have of accumulating mutations. In fact, we know that tumors rapidly accumulate a large number of mutations and that many of their genome repair mechanisms do not work well. But now, we have discovered that many of these genetic differences have to do with our evolutionary history".

Txema Heredia-Genestar, first author of the study who recently completed his Ph.D. at the IBE

When an individual's genome is sequenced, it is observed to have a small number of new mutations -- some 60-- compared to their parents, those of their parents with respect to their grandparents, and so on with each previous generation. Therefore, in a person, approximately three million mutations can be seen that represent the evolutionary history of the mutations accumulated over hundreds of thousands of years. Of these, a few are recent and most are very old.

However, when tumor mutations are analyzed, what is seen are just the mutations that have taken place during the tumor process, since the analysis does not take into account the information on populational history.

"We have seen that the distribution of mutations in the human genome is skewed because of human evolutionary history", Heredia-Genestar details. The manner in which a tumor accumulates mutations is the same as a human cell has of accumulating mutations. "But, we do not see this in the human genome because we have had such a complicated history that has made our distributions of mutations change, and this has deleted the signals we should have", he adds.

Throughout history, the human population has suffered drastic declines and has even repeatedly been on the verge of extinction. This phenomenon is known as a bottleneck, and it causes humans as a species to have very little diversity and fewer mutations: they are very similar to each other. In fact, chimpanzees are four times more genetically diverse than humans.

Therefore, the global way for a cell to accumulate mutations can be observed in chimpanzees because they have not undergone these population events. The study concludes that to understand how mutations accumulate in human cells, which is important for studying tumors, it is more useful to look at how they accumulate in other primates rather than looking at it in human populations , whose signal was destroyed by population events.

"Cancers, like chimpanzees and gorillas, only show the complete mutation landscape of a normal human cell. It is we humans, with our turbulent distant past, who display a distorted distribution of mutations", adds Arcadi Navarro, ICREA research professor at the IBE, full professor at UPF and co-leader of the study.

The research suggests that the conservation and study of the great apes could be highly relevant to understanding human health. David Juan, co-leader of the study, concludes that "in the particular case of the development of tumors, other primates have proved to be a better model for understanding how tumors develop at genetic level than humans themselves. In the future, our closest relatives could shed light on many other human diseases".

Source:

Journal reference:

Heredia-Genestar, J.M., et al. (2020) Extreme differences between human germline and tumor mutation densities are driven by ancestral human-specific deviations. Nature Communications. doi.org/10.1038/s41467-020-16296-4.

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Distribution of human tumor mutations more similar to that of chimpanzees, gorillas - News-Medical.net