Category Archives: Dermatology

Qualitative Research Increasing Throughout Dermatology – MD Magazine

Lucinda L. Kohn, MD, MHS

Credit: Children's Hospital Colorado

Qualitative research that which better helps contextualize health outcomes based on societal and demographic factors have become more prevalent in dermatology, according to a new scoping review from a team of dermatology investigators.1

The new assessment, led by Micah G. Pascual, BS, and Lucina L. Kohn, MD, MHS, of the department of dermatology at the University of Colorado Aurora School of Medicine, showed that nearly 1 in 5 dermatology research articles identified in their analysis included qualitative outcomesand that a majority of said qualitative studies investigated the patient experience regarding the key topic.

The findings highlight an increasing interest to include patient perspective in dermatologya specialty particularly burdened with assuring improved quality-of-life and comprehensive wellness for its patient populations.

Pascual, Kohn and colleagues conducted their review to accomplish both an assessment of the current approaches of qualitative investigation in dermatology, as well as to interpret qualitative trends and their impact and applicability on dermatology. At its most optimal use, qualitative research may help dermatologists and researchers in the field come into better understanding of individuals impacted by skin diseases based on their cultures and backgrounds.

Qualitative research can elicit narratives from participants to capture the unique experiences of health care stakeholders (ie, patients, health care clinicians, and caregivers) that would otherwise remain hidden with quantitative investigation alone, they noted.

Among the 6 common methodologies of qualitative research are content analysis, grounded theory; phenomenology, ethnography; discourse analysis; and case study. Each methodology provides a unique utility for researchers and goals for execution, as well as data collection methodsincluding interviews, focus group discussions, observations, and document analyses.

However, to our knowledge, the extent to which researchers have conducted qualitative studies in dermatology is unknown, investigators wrote.

The team conducted a scoping review of 2 medical research databases to identify dermatology qualitative studies. They excluded articles that which were published in a language other than English; involved mixed, quantitative, systematic review or meta-analysis methods; or were not specific to general, medical, pediatric, invasive, pathologic dermatology or education and training in the field.

Among the 1398 articles reviewed by the investigators, 249 (17.8%) were defined as qualitative dermatology studies. The most commonly observed methodologies were content analysis (n = 58 [23.3%]) and grounded theory (n = 35 [14.1%]). Case studies comprised only 5 (2.0%) of all qualitative studies.

The most prevalent data collection methods included individual interviews (n = 198 [79.5%]) and focus groups (n = 45 [18.1%]). Patients were the primary participants of qualitative studies (n = 174 [69.9%]), followed by health care team members (n = 68 [27.3%]). Sample sizes were primarily 21 participants (n = 127 [51.0%]).

The most prominent topics of the qualitative studies were patient experience (n = 137 [55.0%]), clinician experience (n = 30 [12.0%]), and skin care comprehension (n = 18 [8.8%]).

Investigators observed that 120 articles (48.2%) were published between 2020 2022, versus 98 (39.4%) published from 2010 2019 and just 29 (11.7%) from 2000 2009.

The team concluded that qualitative research is on the rise in dermatology, featuring topical focuses on quality-of-life instrument development and utility; clinician experience with disease treatment; consumer opinion on skin care productions and pharmacotherapeutic options; and perspective on policies regarding skin health care.

As use of qualitative methods grows in dermatology research, it is increasingly important that dermatologists and researchers become familiar with these techniques, they wrote. Many universities offer in-person or online workshops detailing an introduction to qualitative research that typically span a few days to a week.

Investigators expressed hope their research highlights the impact and benefit of qualitative research, as well as the increasing opportunities for said research for dermatologists.

References

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Qualitative Research Increasing Throughout Dermatology - MD Magazine

U.S. Dermatology Partners Announces The Opening Of Sulphur … – EastTexasRadio.com

U.S. Dermatology PartnersJoanna Alters-PA C

U.S. Dermatology Partners expands access to dermatology care to patients in Hopkins County with the opening of their newest office location

WHAT:U.S. Dermatology Partners, one of the leading dermatology groups in the country, is pleased to announce the opening of its newest office location in Sulphur Springs, Texas. The new office marks the organizations 100th location and is part of their Outreach Program serving rural communities and offers convenient access to dermatology and skin cancer treatments. The new office provides treatment in Hopkins County for patients of all ages for dermatologic conditions, including acne, psoriasis, eczema, and skin cancer.Celebrating this achievement, The newU.S. Dermatology Partners Sulphur Springswill provide FREE Skin Cancer Screenings by appointment onlyat their new location to help residents who may have never had a skin check before know if they are at risk for skin cancer. Additionally, they will provide free sunscreen to help people continue their preventative care outside of the dermatologists office.

Certified Physician Assistant,Joanne Alters, will be the primary practitioner at the Sulphur Springs office with oversight from Board-Certified Dermatologist Dr. Martha McCollough. Joanne is a Diplomate of the Society of Dermatology Physician Assistants and is a member of the American Academy of Physician Assistants. Her clinical interest includes skin cancer screening and treatment and other dermatological conditions such as acne, rashes, rosacea, and eczema.

Joanne and her husband are thrilled to be in East Texas to raise their son near the family ranch. They enjoy being outdoors, spending time with family, and attending church.

For questions or to make an appointment for the FREE Skin Cancer Screening, please call the office at (903) 582-4424 ext. 6350.

WHEN:Wednesday, April 26th, from 1:00 pm until 4:00 pm. by appointment only

WHERE:U.S. Dermatology Partners Sulphur Springs

601 Airport Rd #140

Sulphur Springs, TX 75482

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U.S. Dermatology Partners Announces The Opening Of Sulphur ... - EastTexasRadio.com

Apex Dermatology opens new office in Avon – Crain’s Cleveland Business

Apex Dermatology continues its steady expansion across the region with a new location in Avon this month, the practice's 13th location.

Now in its 12th year, the physician-owned and locally managed practice held a ribbon-cutting ceremony on Tuesday, April 25, for the newest office, located at 6855 American Way.

The plan is to gradually roll out all of Apex's offerings in Avon as volumes grow, said Dr. Jorge Garcia-Zuazaga, Apex founder and president.

"It's designed so that we can do aesthetic, medical and surgical dermatology just like our other offices," he said. "So you know, as we grow in that office, and the community, then we'll start adding all those services."

He hopes to have Mohs Surgery a specialized procedure Apex offers to remove certain types of skin cancers and the full range of Apex's aesthetics dermatology offerings online at the Avon office within the next year.

"We realized that, you know, the Avon population is growing (and) that community is in need of a lot of these procedures," Garcia-Zuazaga said. "And we feel that if we educate patients, and we provide the services, then the patients will come in and take a look at Apex."

Dr. Cynthia Lavery Henry, a board-certified dermatologist who has been practicing in Apex's Westlake office, will serve patients in the new Avon location, along with board-certified nurse practitioner Debi Sorg.

The Avon location, which has been seeing patients since early April, has a staff of about 10, including Henry, Sorg, their team of medical assistants and office staff.

"We anticipate that we're going to hire probably another four or five people in the next year to that office," Garcia-Zuazaga said.

Apex also is on track to open its corporate headquarters in Mayfield Heights in July, and is on budget for the $8 million project at the corner of Landerbrook Drive and Cedar Road. The 18,000-square-foot, single-story facility will include a clinical office, lab, research center, dedicated aesthetic clinic and the practice's corporate headquarters. Apex's current Mayfield Heights practice will move into the new building, adding to the overall square footage but not office count for the practice that has been pacing at roughly one new location a year.

"One of the things we do at Apex is we concentrate on quality rather than quantity, right?" Garcia-Zuazaga said. "We want to make sure that we do the right thing."

Henry, who grew up in Medina, is passionate about treating general and cosmetic dermatology for all ages, as well as patient education particularly around sun protection and early skin cancer detection, according to the release.

Sorg, who was raised in Avon, discovered her love for dermatology while working in the field as a medical assistant before becoming a registered nurse. She worked in clinical research as an RN while completing her master of science degree in nursing at Walsh University, according to the release. Her interests span general and cosmetic dermatology for patients of all ages.

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Apex Dermatology opens new office in Avon - Crain's Cleveland Business

Four Abstracts on Eblasakimab and Farudodstat to be Presented at … – Dermatology Times

Gennady Danilkin/AdobeStock

The 1st International Societies for Investigative Dermatology (ISID) Meeting takes place next week, May 10-13, 2023, in Tokyo, Japan. ASLAN Pharmaceuticals will present 2 late-breaker presentations and 2 published abstracts on eblasakimab for atopic dermatitis and farudodstat for alopecia areata.

Late-breaker presentation:

Late-breaker poster presentation:

Published abstracts:

1. Eblasakimab monotherapy improves moderate-to-severe atopic dermatitis symptoms across anatomical regions in a phase 1 study (abstract ID: 657)

ASLANs first published abstract at ISID explores eblasakimab as monotherapy for moderate-to-severe atopic dermatitis across varying regions of the body. According to the background of the study, the clinical presentation of atopic dermatitis varies by anatomical location due to differences in skin area sensitivity and can therefore limit a patients long-term treatment options. New research shows that interleukin-4 (IL-4) and IL-13 signal through a type 2 receptor complex composed of IL-4R1 and IL-13R1 to mediate the pathogenesis of atopic dermatitis.

Eblasakimab obstructs the signaling cascade by binding to the IL-13R1 subunit. The phase 1b subgroup analysis analyzed the effects of eblasakimab on Eczema Area and Severity Index (EASI) across varying anatomical regions compared to placebo. Investigators found that patients treated with 400mg or 600mg of subcutaneous eblasakimab once a week showed notable improvement in percent change from baseline in EASI scores across 4 anatomic regions of the head/neck, trunk, upper extremities, and lower extremities, compared to placebo.

2. Neuromodulation beyond itch is blocked by targeting IL-13R1 with eblasakimab (abstract ID: 1594)

The second published ASLAN abstract at ISID evaluated whether IL-4 and IL-13 exert redundant or distinct functions in human sensory neurons, and whethereblasakimabcanattenuate cytokine-enhanced neuronal responses to itch andreduce spontaneous neuronal activity. According to the abstract, Human dorsal root ganglia neurons were treated with IL-4, IL-13, or their combination with or withouteblasakimaband subsequently either challenged with pruritogens (BAM8-22 and PAMP-20) or tested for spontaneous neuronal activity. Neuronal responses to pruritogens and spontaneous neuronal activity were measured via live-cell calcium imaging.

IL-4, IL-13, and their combination treatments enhanced neuronal responses to the non-histaminergic pruritogen (BAM-822) when applied to human dorsal root ganglion, and IL-13 treatment increased neuronal responses to the histaminergic pruritogen (PAMP-20) through amplifications of the activity of MRGPRX2. Investigators noted that this suggests a novel neuroimmune pathway besides its mast cell specific function

Updates

Eblasakimab, a potential first-in-class antibody targeting the IL-13 receptor in moderate-to-severe atopic dermatitis is being studied in a global phase 2b trial of patients with moderate-to-severe atopic dermatitis with topline data expected in early July 2023. Farudodstat, a potent oral inhibitor of the enzyme DHODH and potential first-in-class treatment for alopecia areata is also under development. ASLAN plans to initiate a proof-of-concept trial in 2Q 2023.

Reference

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Four Abstracts on Eblasakimab and Farudodstat to be Presented at ... - Dermatology Times

Dermatology Publications in Saudi Arabia: A Fast-Growing Pattern – Cureus

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Dermatology Publications in Saudi Arabia: A Fast-Growing Pattern - Cureus

Assessing the Ability of Non-dermatology Physicians to Recognize … – Cureus

Specialty

Please chooseI'm not a medical professional.Allergy and ImmunologyAnatomyAnesthesiologyCardiac/Thoracic/Vascular SurgeryCardiologyCritical CareDentistryDermatologyDiabetes and EndocrinologyEmergency MedicineEpidemiology and Public HealthFamily MedicineForensic MedicineGastroenterologyGeneral PracticeGeneticsGeriatricsHealth PolicyHematologyHIV/AIDSHospital-based MedicineI'm not a medical professional.Infectious DiseaseIntegrative/Complementary MedicineInternal MedicineInternal Medicine-PediatricsMedical Education and SimulationMedical PhysicsMedical StudentNephrologyNeurological SurgeryNeurologyNuclear MedicineNutritionObstetrics and GynecologyOccupational HealthOncologyOphthalmologyOptometryOral MedicineOrthopaedicsOsteopathic MedicineOtolaryngologyPain ManagementPalliative CarePathologyPediatricsPediatric SurgeryPhysical Medicine and RehabilitationPlastic SurgeryPodiatryPreventive MedicinePsychiatryPsychologyPulmonologyRadiation OncologyRadiologyRheumatologySubstance Use and AddictionSurgeryTherapeuticsTraumaUrologyMiscellaneous

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Assessing the Ability of Non-dermatology Physicians to Recognize ... - Cureus

sunscreens dermatologists recommend and use themselves – Yahoo News

Youve heard it before: You should wear sunscreen often, and ideally every day. Dermatologists dont just talk about the importance of wearing sunscreen they practice what they preach. I wear it every day, 365 days a year, Dr. Gary Goldenberg, assistant clinical professor of dermatology at the Icahn School of Medicine at Mount Sinai in New York, tells Yahoo Life. (His top pick for daily wear is EltaMD's Sunscreen Sport Lotion). "Even in winter, you still get some UV that can cause skin damage."

And they make it easy to remember: I actually incorporate sunscreen into my daily grooming routine and apply it right after shaving, Dr. Joshua Zeichner, a New York Citybased dermatologist, tells Yahoo Life. These are the best sunscreens that dermatologists recommend and actually use themselves. We've got something in the mix for every skin type, whether you have sensitive skin, dry skin, oily skin, skin-type blends or something in between.

Originally published April 26, 2023 at 1:25 AM

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sunscreens dermatologists recommend and use themselves - Yahoo News

FDA Gives the Green Light for Cheek Wrinkle Solution – Dermatology Times

The US Food and Drug Administration (FDA) has given clearance for injectable poly-L-lactic acid (PLLA-SCA; Sculptra) to correct the effects of aging in cheeks.1 During clinical trials (NCT04124692), patients (n=110) showed significant improvement in the reduction of fine lines and wrinkles in 3 months (96%), 1 year (94%), and 2 years (94%). Each study participant was given 8ml of the PLLA-SCA. "The primary endpoint was reached, which was 1-grade improvement in cheek wrinkles at rest and its secondary endpoint of addressing cheek wrinkles when smiling for up to 2 years, researchers explained.2

Galderma said Sculptra is the first FDA-approved PLLA collagen stimulator that smooths wrinkles and improves firmness and glow in the cheek for up to 2 years. The injectable was first approved for aesthetic use in 2009 inthe USfor the correction of nasolabial folds and other facial wrinkles. In 2004, the injectable was approved for the restoration and correction of fat loss in HIV patients. PLLA-SCA is currently available in more than 40 countries.

Sculptra is a foundational treatment that helps smooth wrinkles and offers the added benefit of improved skin qualityhelping to firm sagging skin for a more radiant and glowing appearance. My patients will be extremely pleased that they can now receive Sculptra in the broader cheek region to support collagen growht and to make their skin look more refreshed and rejuvenated, shared Sabrina Fabi, MD in a press release. Fabi is a double board-certified dermatologist and cosmetic surgeon in California and served as an investigator in the PLLA-SCA clinical trials for cheek wrinkles.

According to Sculptras website, common adverse effects to the injectable include injection site swelling, tenderness, redness, pain, bruising, bleeding, itching and lumps. Other effects reportedinclude lumps under the skin, some with delayed onset with or without inflammation or skin discoloration. Galderma warned that PLLA-SCA should not be administered to patients with a history of keloid formation or hypertrophic scarring. Safety has not been established in patients who are pregnant, lactating, breastfeeding, or under 18 years of age.3

References

1. Galderma. Galderma receives FDA approval for SCULPTRA for cheek wrinkles. PR Newswire: press release distribution, targeting, monitoring and marketing. https://www.prnewswire.com/news-releases/galderma-receives-fda-approval-for-sculptra-for-cheek-wrinkles-301807665.html. Published April 26, 2023. Accessed April 26, 2023.

2. Bohnert K, Dorizas A, Lorenc P, Sadick NS. Randomized, controlled, multicentered, double-blind investigation of injectable poly-L-lactic acid for improving skin quality.Dermatol Surg. 2019;45(5):718-724. doi:10.1097/DSS.0000000000001772

3. Youthful skin starts within. Sculptra Aesthetic. Accessed April 26, 2023. https://www.sculptrausa.com/.

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FDA Gives the Green Light for Cheek Wrinkle Solution - Dermatology Times

Do Spray Sunscreens Actually Work Well? – Verywell Health

Key Takeaways

Spray sunscreens, also known as aerosol sunscreens, have been gaining popularity as a convenient sun protection tool without the sticky hassle of lotion sunscreen. Some companies are even promoting facial sunscreen sprays with added benefits, such as a matte finish or hydrating glow.

But some spray sunscreens have been recalled for having cancer-causing ingredients, and they may not be as effective as regular lotion formulas. Heres a guide on how to choose the right spray sunscreen and use it properly, according to dermatologists.

You have to rub the spray sunscreen in after spraying it on your skin and theres no such thing as a no rub formula, according to Steve Daveluy, MD, a board-certified dermatologist and an associate professor in dermatology at Wayne State University.

You should spray an even coat before rubbing to avoid uneven coverage and burns, Daveluy added. If its windy outside, spray the sunscreen on your hands and rub it onto your skin. Even if its a facial spray, avoid spraying it directly on your face and use your hands to apply the sunscreen instead.

Anne Chapas, MD, a New York-based board-certified dermatologist and a member of the American Academy of Dermatology, said parents should also be aware of the direction the wind is blowing when applying spray sunscreen on children.

Daveluy said spray sunscreens work just as well as creams or lotions as long as you use them correctly. But try to look for a spray thats made without an aerosol propellant, which may dilute the sunscreen and harm the environment.

Propellant was responsible for benzene, a cancer-causing chemical, found in some recalled spray sunscreens, Daveluy said. While benzene wasnt an added ingredient in these sunscreens, it could have been a byproduct or contamination from propellant.

The levels of benzene found in the recalled sunscreens were also not as high as what people would have been exposed to in gasoline, paints, glues, and cigarette smoke, Daveluy explained.

The biggest downside to using a spray sunscreen is that youre prone to applying the product unevenly and incorrectly.

Chapas said its difficult to know if youve used enough sunscreen to cover all the sun-exposed areas of the body and you might waste more product if you need to use multiple coats.

Theres also the risk of inhaling the spray. While spray sunscreens are safe for our skin and bodies, they shouldnt be consumed or inhaled. Daveluy said to make sure you never spray directly toward your head or face, especially when its windy.

You should also avoid using spray sunscreens near an open flame because the alcohol content in the product is flammable.

Spray sunscreens do have some advantages over traditional cream or lotion sunscreens.

Daveluy said he loves using spray sunscreen when hes working out or doing any outdoor activities because its easier to apply over sweaty, moist skin.

For Chapas, spray sunscreens are good for those in a hurry because they dry quickly. They can also cover certain body parts that are harder to reach with hands.

Mineral sunscreens, including spray ones, are becoming popular because they work well for sensitive skin. With zinc oxide or titanium dioxide as the active ingredient, mineral sunscreens are less likely to cause irritation and rashes.

Daveluy said this type of sunscreen is safer than safe because the ingredients are also used in diaper rash cream for babies.

Chapas added that mineral sunscreens are also safer for the environment, especially if youre diving or swimming.

Whether you decide to go with a spray sunscreen this summer or not, the best product is the one that you like and want to use. For any sunscreen, its all about finding something you like so that you will use it regularly, Daveluy said.

Spray sunscreens can offer effective sun protection if used correctly. But be careful not to spray the product directly onto your face or head, especially when it's windy. You should also avoid using it near an open flame to avoid burn risks.

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Do Spray Sunscreens Actually Work Well? - Verywell Health

The Role of Exercise in Atopic Dermatitis, Spontaneous Urticaria – Dermatology Times

While engaging in physical activity can improve mental health symptoms, researchers said it can also exacerbate certain skin conditions, such as atopic dermatitis and chronic spontaneous urticaria (CSU).

N F/peopleimages.com/AdobeStock

In a study,1 researchers examined prior research related to a correlation between the 2, including existing literature on the anti-inflammatory effects of exercise and reduced inflammation and dermatitis symptoms in exercising mice. Using this existing knowledge coupled with the knowledge that physical activity and exertion can lead to exacerbated atopic dermatitis and lead to itchy hives in patience with CSU, researchers sought to further examine the correlation.

Furthermore, they sought to analyze exercise patterns among patients with atopic dermatitis and CSU, citing limited existing research on the subject.

In the cross-sectional study, researchers developed a questionnaire based off of patient-reported outcome measures.

135 patients with atopic dermatitis and 131 patients with CSU were enrolled in the study from outpatient clinics and private dermatology clinics in Aarhus, Denmark. Participants were required to be at least 18 years of age and meet the diagnostic criteria of either condition.

Researchers collected several pieces of information, including demographic data, skin disease onset and treatment data, and exercise habits or observations. This included asking participants to describe whether their personal condition was affected by exercise.

They also utilized several scales and indexes, including:

Of the 135 participants with atopic dermatitis included in the study, 104 reported regular exercise habits. Of these, 62% reported receiving biological treatments, and 81% reported experiencing exacerbation of their condition due to exercise. These numbers were significantly lower in those with atopic dermatitis who did not exercise regularly.

Compared to their non-exercising counterparts, participants with atopic dermatitis who engaged in regular exercise reported lower symptom rates of depression, anxiety, insomnia, activity impairment, and disease severity. However, their average DLQI and EASI scores were higher than those who did not exercise.

Additionally, when exacerbation of their disease through sweat and exercise was taken into account, patients with atopic dermatitis reported higher DLQI and POEM scores, as well as higher work impairment and symptoms of depression, anxiety, and insomnia.

Of the 131 participants with CSU included in the study, 97 reported regular exercise habits. Of these, 52% reported receiving biological treatments, and 70% reported experiencing cholinergic urticaria, or itchy hives brought on by exertion.

Compared to their non-exercising counterparts, participants with CSU who engaged in regular exercise reported lower symptom rates of depression, insomnia, and work impairment. They also reported a lower average UCT disease control score. However, their average DLQI, activity impairment, and UAS7 disease severity scores were higher than those who did not exercise.

Additionally, when exacerbation of their disease through sweat and exercise was taken into account, patients with CSU reported higher DLQI scores, work impairment, activity impairment, and UCT and UAS7 disease severity scores, as well as symptoms of depression, anxiety, and insomnia.

We found that exercising AD [atopic dermatitis] patients had significantly fewer symptoms of depression and anxiety and significantly less insomnia, though their disease severity did not differ from that of the non-exercising AD patients, study authors wrote. A large proportion of patients experienced exacerbation of AD in relation to exercising and sweating. Yet, this did not affect disease severity, QoL [quality of life], or mental health.

Researchers also noted that patients with atopic dermatitis typically exert less physical activity than the general population.

Potential study limitations, as noted by the authors, included participants having potentially received effective atopic dermatitis treatment in the hospital and clinical settings they were recruited from, questionnaire length, and a lack of clarity in the causality between exercise and other parameters.

It seems as if CSU patients, who are limited in their exertion of exercise, are additionally psychologically oppressed by the lifestyle constraints of their disease, study authors wrote. The benefits of exercise may be unobtainable due to the nature of CSU.

Reference

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The Role of Exercise in Atopic Dermatitis, Spontaneous Urticaria - Dermatology Times