Category Archives: Dermatology

How, where to get medical records from closed Myrtle Beach dermatology office – wpde.com

MYRTLE BEACH, S.C. (WPDE)

Thousands of local dermatology patients are one step closer to getting their medical records back after Dermatology and Skin Cancer Center SC closed without warning in February.

It has now been more than 40 days that patients haven't been able to access their records, and many of these patients have cancer.

ABC15 first broke the story afterseveral patients reached out to us to investigate the unexpected closure.

READ MORE: Patients say MB dermatology office closes, fails to disclose medical records, requests

The office abruptly closed without warning to either employees, and patients, on February 17, and never reopened.

Initially, ABC15reached out to the South Carolina Department of Labor Licensing and Regulationin March to askhow patients could get their records back.

Now, alongside the state Board of Medical Examiners, they have officially enacted a petition appointing another doctor as the custodian for these records.

Dermatology and Skin Cancer Center SC Myrtle Beach office (Credit: Emma Parkhouse/WPDE)

Here's how to do it.

The Board confirmed the associated medical offices were closed down after a transfer of ownership fell through.

The initial owner, Dr. Joseph Masessa, died in 2019.

His practice was taken over by his brother, Jeffery Masessa, who is not a licensed physician in South Carolina.

According to the Board, Jeffery never reached out to the state's labor department or the Board about the closure; or made any arrangements for record retrieval.

SUGGESTED: Patients can retrieve records after Myrtle Beach dermatology office unexpectedly closed

The board determined while Jeffery Masessa may have once been considered a "responsible party at one point in time", he no longer is.

In addition, because Dr. Joseph Masessa is deceased, the Board has the legal authority to appoint a custodian of the records.

Board-certified surgeon and dermatologist, Dr. Brandon Coakley at Waccamaw Dermatology has been selected as that custodian.

"Patients have been panicked. There's patients that went into the doctor's office and were told, 'hey, you have a spot that's suspicious for cancer'; a biopsy was taken, and then there was no answer," said Coakley.

Waccamaw Dermatology office in Myrtle Beach (Credit: Emma Parkhouse/WPDE)

Dr. Coakley told ABC15 according to the closed office's former manager,Dermatology and Skin Cancer Center SC in Myrtle Beach had roughly 36,000 patient visits in 2022.

Even if those patients attended the office multiple times throughout the year, Coakley says there will be at least 10,000 patients impacted by this.

He's still waiting to hear back about a confirmed number of patient files.

While he's not sure exactly how many thousands of records there are at the moment, Dr. Coakley is sure that he wants to help these patients in anyway he can.

"We will be contacting, as per the medical board's order, contacting every patient to let them know that we have the records," said Coakley. "I don't know the state of the paper records. My plan is to contact everybody who had an email on file electronically because that's faster and easier, but we will go through the process of organizing the paper records and notifying those people by regular first class mail."

Dr. Coakley and his office staff at Waccamaw Dermatology will be receiving all of the paper and digital records from Dermatology and Skin Cancer Center SC over the next couple of days.

Waccamaw Dermatology andDermatology and Skin Cancer Center SC are not associated or affiliated with each other.

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ABC15 got ahold of Jeffery Masessa Tuesday afternoon.

Over the phone, our reporter asked him if he was available for an interview to talk about the closing of the dermatology offices he owns in South Carolina.

He agreed to an interview and said he would call back after a meeting to set it up. Since then, he has not returned any phone calls or texts.

The Board and the state LLR have stated they have still not heard from, or been able to get in contact, with Jeffery Masessa.

Dr. Coakley says he and his team will be working as quickly as possible to obtain and organize the records as they prepare to directly contact everyone whose been affected.

Updates on obtaining medical records for former patients ofDermatology and Skin Cancer Center SC will be posted here.

His office is located at 5046 Highway 17 Bypass South, in Suite 200.

This is a developing story. Stay with ABC15 News for updates.

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How, where to get medical records from closed Myrtle Beach dermatology office - wpde.com

Dermatology Month in Review: Highlights from March 2023 – MD Magazine

This past month on HCPLive, several important topics were covered as part of our dermatology content from March.

The list includes new trial data on psoriasis, atopic dermatitis (AD), hidradenitis suppurativa (HS), and prurigo nodularis (PN) treatment options.

The following list is a summary of these major breakthroughs covered in March in the dermatology space, with more news and updated content on these topics available on the HCPLive main news page.

1. Positive Phase 3 Trial Results for Tapinarof Cream on Atopic Dermatitis

In this HCPLive article, phase 3 data from the ADORING 2 trial indicated that about of half of AD patients treated with tapinarof, 1% showed improvement on the Validated Investigator Global Assessment for Atopic Dermatitis (vIGA-ADTM).

The investigators noted that tapinarof may be potential two-in-one first-line topical treatment for both atopic dermatitis and plaque psoriasis, as the new trial found the cream to be both safe and tolerable for all age groups down to 2 years.

The study results were announced by biopharmaceutical company Dermavant Sciences.

2. Positive Trial Results for Hand, Foot Eczema Patients Treated with Dupilumab

This late-breaking data was shown at the American Academy of Dermatology (AAD) 2023 conference, showing that about 40% of uncontrolled moderate-to-severe hand and foot AD patients achieved clear or almost clear skin compared to 17% with placebo.

The researchers saw improvements as early as 1 week, noting that there were substantial improvements in measures of sleep, skin pain, as well as hand eczema-related life quality. They noted that the drug was the first biologic evaluated for this particular patient population.

The data was presented by Eric Simpson, MD, the studys principal trial investigator.

3. Nemolizumab Treatment Led to Improved Skin Lesions, Itch for Prurigo Nodularis Patients

Phase 3 data from the OLYMPIA 2 trial, presented at AAD, showed that nemolizumab monotherapy improved skin lesions, itch, and sleep disturbances in adults with moderate-to-severe prurigo nodularis (PN).

The investigators reported that nemolizumab, a first-in-class, interleukin-31 receptor alpha antagonist, met all of the studys primary and key secondary endpoints.

The late-breaking results were presented by Shawn Kwatra, MD, from Johns Hopkins University School of Medicine.

4. Once Daily Roflumilast Improved Symptoms of Atopic Dermatitis in Phase 3 Trials

This late-breaking data, presented at AAD, showed that roflumilast 0.15% once-daily improved AD across multiple efficacy endpoints and produced favorable safety and tolerability in patients.

The results showed that adverse events (AEs) were reported in less than 3.5% of patients, and application site pain incidence was low. The data resulted from the INTEGUMENT-1 and INTEGUMENT-2 studies.

The results were presented by Lawrence Eichenfield, MD, from Rady Children's Hospital.

5. Phase 3 Trial Data on Bimekizumab for Patients with Hidradenitis Suppurativa

This data, also presented at AAD, indicated that a greater percentage of HS patients achieved HiSCR50 for those treated with bimekizumab compared to placebo at week 16 of the study.

The results came from the BE HEARD I and II trials investigating the selective inhibition of IL-17F and IL-17A by bimekizumb, a monoclonal IgG1 antibody.

The research was presented at the conference by lead investigator Alexa B. Kimball, MD, from Beth Israel Deaconess Medical Center.

6. Oral Roflumilast Effective, Safe in Treating Plaque Psoriasis Over 24 Weeks

In this study, oral roflumilast treatment was found to lead to significant Psoriasis Area and Severity Index (PASI) score, with 34.8% of their treatment group reached PASI75 compared to 0.0% in given placebo by week 12.

The late-breaking data on oral roflumilast, a targeted phosphodiesterase (PDE)-4 inhibitor, was presented at AAD 2023. The research team also stated that roflumilast may become a cheap alternative treatment to other psoriasis drugs with more research.

The findings were presented by Alexander Egeberg, MD, PhD, from the University of Copenhagen and Bispebjerg Hospital.

7. Oral TYK2 Inhibitor Led to Significant Skin Clearance Improvement in Psoriasis

These results showed that treatment with TAK-279 (formerly NDI-034858), an oral tyrosine kinase 2 (TYK2) inhibitor, led to significant skin clearance improvement for moderate-to-severe psoriasis patients compared to placebo, especially at a once-daily, 5 mg dose.

The phase 2b clinical trial data was shown at AAD, and the investigators demonstrated that at the highest dose of TAK-279, 33% of study participants reached complete skin clearance by week 12.

The data was presented at the conference by April W. Armstrong, MD, MPH, from USCs Keck School of Medicine.

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Dermatology Month in Review: Highlights from March 2023 - MD Magazine

Pure Dermatology will bring skin care, treatments to South Austin – Community Impact Newspaper

Pure Dermatology is coming in May to South Austin and promises to bring skin checks, treatments and more at 8701 Hwy. 71, Ste. 101, Austin.

Opening day will be May 16, said co-owner Dr. Christopher Chu. His wife, Dr. Chelsey Straight, will also be a partner in the dermatology practice. Both are board-certified dermatologists. Chu is also a board-certified dermatopathologist, while Straight is also a board-certified micrographic surgeon.

Services provided will include skin checks, skin cancer treatments including surgical excision and micrographic surgery, treatment of common skin conditions such as acne, rosacea, eczema, psoriasis, warts, etc., hair loss consultations and treatments, and cosmetic treatments including Botox/Dysport, injectable fillers and chemical peels.

For more information, call 512-766-2610 or visit http://www.puredermtx.com in May.

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Pure Dermatology will bring skin care, treatments to South Austin - Community Impact Newspaper

Fatty Liver More Frequent in Alopecia Universalis and Patchy … – Dermatology Times

Nadya Kolobova/AdobeStock

A recent study published in the Journal of Cosmetic Dermatology examined the frequency of fatty liver in patients with alopecia areata subtypes, including alopecia universalis (AU) and patchy alopecia areata (PAA).1 After reviewing data from patients with AU and PAA referred to a dermatology clinic from September 23, 2019, to September 23, 2020, study investigators determined that fatty liver was more frequent in patients with AU and PAA compared to a control group, but without statistically significant differences.

Patients without hair loss disorders who attended the same clinic were selected as the control group. Additionally, patients with known liver diseases were excluded from the case-control study. The study investigators began collecting data from the AU and PAA patient groups, including age, sex, weight, and waist circumference. Disease duration and the Severity of Alopecia Tool (SALT) score were also documented among the AU and PAA patient groups.

Overall, 32 patients were included in each study group: AU, PAA, and control. Age, sex, weight, height, BMI, and waist circumference were comparable across all 3 groups. The study investigators found that the frequency of hyperlipidemia was the highest in AU patients (31.3%), followed by PAA patients (15.6%), but the difference was not statistically significant among the groups (p=0.131). Abnormal liver enzymes were recorded in 9.4% of AU patients, 12.5% of PAA patients, and 3.1% of controls (p=0.524). Statin use was also the highest in AU patients (28.1%), with no statistically significant difference among the 3 groups. Finally, disease duration and SALT score were significantly higher in the AU patient group than in the PAA patient group (p=0.009 andp<0.001, respectively).

The study investigators noted that The higher frequency of fatty liver in AU patients compared with the PAA group can be attributed to the longer disease duration and the higher SALT score in this group. To the best of our knowledge, in previous studies, fatty liver has not been evaluated in patients with AA. Still, recently the replacement of nonalcoholic fatty liver disease (NAFLD) with metabolic dysfunction-associated fatty liver disease (MAFLD) has been proposed, highlighting the association between fatty liver and metabolic syndrome.

The investigators also noted that the higher frequency of fatty liver in AA patients may be related to an oxidant/antioxidant imbalance, which was reported in the studys patients. Overall, the study suggests that there may be an association between fatty liver and the AU subtype, but larger studies are needed to confirm the correlation.

Reference

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Fatty Liver More Frequent in Alopecia Universalis and Patchy ... - Dermatology Times

Dermatologist Jessie Cheung on How to Make Your Penis Bigger – Men’s Health

NO SURPRISE TO anyone whos been living on planet Earth, but a lot of men want to have a bigger penis. The thing is, we cant go to the gym, do three sets of dumbbell penis reps, and get a larger schlong. If it were that easy, nearly every guy would be walking around with a snake in his pants.

Still, there actually are some things you can do to get a bigger penis, but many of these procedures are not cheap and come with some serious health risks. Nevertheless, we know you're probably curious about the wild world of penis enlargement, which is why we reached out to Jessie Cheung, M.D., a board-certified dermatologist who specializes in some of these techniques. Cheung has been a dermatologist for nearly 20 years, and six years ago, she moved from doing medical dermatology to focusing exclusively on cosmetic and sexual dermatology.

In addition to standard facial cosmetic procedures, Cheungwho's based in Manhattan and Chicagoperforms a slew of penis procedures, including fillers, fat injections, Bocox (that's Botox for your cock, FYI), and Emsella (a form of electromagnetic therapy that helps with premature ejaculation and erection strength.)

We interviewed Cheung about her dermatological methods for making patients' penises bigger, longer, and even capable of lasting longer during sex.

This interview has been lightly edited and condensed for clarity.

I dont want to brag, but a lot, hundreds. As a dermatologist, I'm used to looking at skin everywhere, including the penis, anus, scrotum, and perineum, and dealing with warts, hemorrhoids, and fissures. I stopped doing medical dermatology years ago and now focus on cosmetics, hormones, and sexual health. So that brings in men who need help with their erectile function, libido, premature ejaculation, and men who have purely cosmetic issues. The big one, of course, is increasing their penis size.

Actually, I see more men who complain about erectile dysfunction instead of size, but they always say that even if they are happy with their size, they wouldn't mind more length or girth.

I give them statistics: Numbers are facts. Interestingly, many of my men who want bigger penises have above-average length and girth. I think porn makes them lose touch with reality, just like we're seeing social media distort our perception of beauty.

Penis length must be 2.5 standard deviations below the average for that age to be considered a micropenis. For adults, that is 9.3 cm when stretched or 3.6 inches. In my office, I consider it a micropenis if they are too short to penetrate their partner.

Not that often. I would say my whole career, probably two that were so small they couldn't penetrateand that's really short. When its that small, they may want surgical intervention, and I dont do penis surgeries. So because of that, I don't see many men with a proper micropenis.

Yeah, so I perform filler injections. I also perform P-shots, which are designed to treat ED but have the additional benefit of increasing size, specifically girth. P-shots involve injecting biological substances such as Platelet-rich plasma (PRP). PRP is a source of growth factors for blood vessels and tissue, so activating the hibernating stem cells in the arteries and nerves stimulates repair and the production of healthy tissue.

P-shots start at $1800 and increase depending on the protocol used.

Ill try not to be too technical, but we draw your blood in these special tubes. We spin it down on the centrifuge, and on the top coat, there's a layer that's kinda yellowy, that's very rich with platelets, which contains eight to ten growth factors that are good for your blood vessels, collagen, and stem cell activation. So we inject that into places where you want to turn on stem cells, whether into your scalp to grow hair, your skin to help with wound healing, or the penis to activate stem cells to make blood vessels and nerves again. That said, PRP is about 10 to 15 years old. I prefer to use exomes.

So, I perform a topical infusion of exosomes, which really is the cutting edge of regenerative medicine. Exosomes are basically little email packets of information that your stem cells secrete to turn each other on and talk to each other. And they're filled with RNA, proteins, and peptides. Exomes have hundreds of more growth factors than PRP. They're also anti-inflammatory. So I use exosomes the exact same way I use P-shots, to help with ED, functionality, and size.

Anti-inflammation helps prevent tissue from aging. So in the case of penises, this will help you retain your functionality and erection strength as you age.

Fat is a great filler, and since fat is full of stem cells, I recommend fat for improving size and restoring erectile function. You will see increased girth and can regain lost length, both flaccid and erect.

A fat transfer to the penis is very straightforward. The injection technique is similar to how we inject the penis with regular fillers, but we are harvesting your own fat with gentle liposuction and processing the fat with PRP or exomes. I like to take fat from the pubic mound, which helps to expose more of the base of the penis to create more visible length. I call it pulling the turtle out of the shell.

Fat is a very cost-effective filler, and since fat functions as a natural implant, it lasts much longer than other fillers. The most significant benefit of using fat is the improvement of functionality, as the wound-healing activation of stem cells will target nerves and blood vessels to improve sensitivity and circulation. I like to transfer at least 20 mL of fat, which starts at $8,000.

There are risks associated with any injection! But understanding the anatomy and potential complications will mitigate those risks. For example, you don't want any material getting into large arteries, which can cause tissue to die. You also have to respect the layers and boundaries of the penis to avoid migration of the filler (i.e., the filler all moving to one place and sitting there). Bruising, swelling, uneven appearance, and infection are potential complications that I warn my patients about.

No, I have never had a patient who asked for a smaller penis. But penises do shrink over time, as testosterone levels fall and there is a decrease in blood flow. The blood vessels and tissue scar down and get stiff, so they can't stretch and fill up with blood for a full erection. As a result, men will notice their penis looking smaller while flaccid and erect and report softer erections.

Typically men in their fifties and sixties, though Ive seen men coming and seeking help for their shrinkage in their thirties.

Staying healthy [and] keeping your hormone levels optimized. [And you do that by] having a good quality of sleep, a healthy diet, keeping stress levels low, and not smoking. So things that are generally thought of as bad for you will negatively affect your penis size as you age.

Yes, my patients love Bocox! It helps with size and erections. Botulinum toxin works by relaxing the smooth muscle in the blood vessels of the penis. This means the blood vessels are more dilated and filled with blood at rest, so the penis hangs longer and thicker when flaccid. So its great if youre a grower and not a shower. But even with an erection, the penis is even more full of blood than usual, so it is harder and may be thicker. Bocox is a relatively safe treatment. It's usually two pokes after the application of a topical numbing cream. Risks include mild bruising and swelling.

So it's electromagnetic therapy. Basically, you're sitting on a chair, and a powerful magnet is at the chair's base. That magnet makes your pelvic floor muscles activate. So essentially, you're doing kegel exercises, whether it be for the penis, the vagina, or the anus. For the penis, that can help with premature ejaculation, but also erection strength and even size because of the increased blood flow. We have men who do Emsella for the anus, specifically sphincter control. There's a statistic that you complete over 11,000 Kegel exercises in 28 minutes on the Emsella chair. So it's very legit, and I love using it on my patients.

I will refuse to treat a patient who has unrealistic expectations. Beyond that, everyone has their own desired aesthetic, so I won't judge a man if he wants to have a huge penis. To each their own!

Social media and porn have created unrealistic expectations for bodies, faces, and genitalia. It's difficult to maintain a smooth, pink anus or vagina or penis or even nipples as we age, and sexual confidence is at an all-time low. Sex is excellent for your physical and mental health and appearance, so a therapeutic procedure that encourages sexual wellness and confidence is not really up to public judgment. It's a private health issue.

I had a patient who had filler injections done elsewhere. He had 15 syringes done in one session, and all the filler clumped up at the head of his penis. It was this huge blob. It looked like a golf ball.

So he came after it was botched to get it fixed. But didnt want to get the filler removed. So what I did was add more filler at the shaft and base, essentially to blend it in better.

Aside from the usual wows, what's memorable are the stories I hear when my patients return: sex multiple times a day, getting propositioned on Snapchat, video parties, and underground fame. My patients are definitely more confident. I had one patient who was too short to penetrate his partner, and after a combination of hormones, a P-shot, and fat transfer, he was finally able to have penetrative sex!

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Dermatologist Jessie Cheung on How to Make Your Penis Bigger - Men's Health

Dr. Arvinder Singh Awarded As Father Of Cosmetic Dermatology In The International Fame Award – Zee News

Dr. Arvinder Singh has been bestowed with the prestigious International Fame Award by the famous Bollywood Actress Shilpa Shetty Kundra. He has been awarded as Father of Cosmetic Dermatology for his contribution to the field of Cosmetic Dermatology, Clinical Cosmetology, Medical Aesthetics, and Medical LASERS.

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As the CEO and MD of the Arth Group of Companies and a cosmetic dermatologist who holds the world record in this field, Dr. Arvinder Singh is well-known for his expertise in chemical peels, botox, and dermal fillers. He is a Rajasthan-based, internationally board-certified cosmetic dermatologist with a specialization in facial aesthetics and clinical cosmetics, including Botox, fillers, LASERS, and thread lifts.

The International Board of Cosmetic Dermatology (IBCD) was founded in London by Dr. Arvinder Singh. The board consists of Dermatologists, Plastic Surgeons, Clinical Cosmetologists and Aesthetic Dentistists. The board was established with the goal of giving medical professionals, such as MBBS, Postgraduate doctors, dentists, and Aayush (BHMS, BAMS, BUMS), high-quality education and career opportunities in the fields of Cosmetic Dermatology, Clinical Cosmetology, Medical Aesthetics, and Medical LASERS.

His Academy, Institute of Aesthetic Medicine, Cosmetology, and LASERS (IAMCL), located in India, has been training non-medical students and professionals also who want to pursue careers in cosmetology and aesthetics and become accredited clinical cosmetologists in the vicinity of aesthetic medicine.

Additionally accredited by the UK and registered in the USA, the IAMCL provides course materials in both Hindi and English languages.

Along with this, Dr. Arvinder Singh also established what is thought to be India's first clinical fitness and cosmetology centre in Udaipur and Jaipur, Rajasthan, which has been accredited by the Quality Accreditation Institute (QAI).

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Dr. Arvinder Singh Awarded As Father Of Cosmetic Dermatology In The International Fame Award - Zee News

The Future of Immunotherapy Targets – Dermatology Times

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Immunotherapy, in the form of immune checkpoint inhibitors (ICI), has been a recent breakthrough in the management of both early and late-stage melanoma. With the advent of immunotherapy, the 1-year survival rate for patients with metastatic disease has increased from 25% to 50%.1 ICIs have contributed to improved outcomes of treatment and prognosis of patients with different malignancies and are now served as a standard treatment for advanced melanoma.2

Recent study results revealed that treatment with combined anti-CTLA-4/anti-PD-1 results in median overall survival and a significant durability response, which is superior to that of nivolumab monotherapy and ipilimumab monotherapy.3 Also, the benefits of combined treatment were similar for patients, irrespective of their BRAFV600 mutational and PD-L1 expression status. ICIs provide a significant response in patients with brain metastasis, particularly those who are asymptomatic of malignant infiltration at the time of presentation.4 Study results also revealed that intracranial responses of combined ipilimumab/nivolumab were more than 50% in patients whose metastases have not been treated with brain radiotherapy.5 Another study found that ipilimumab/nivolumab was significantly superior to nivolumab monotherapy with a 5-year survival rate of 51% in patients with asymptomatic disease.6 In the therapeutic field of melanoma, prior immunostimulatory treatments such as interleukin-2 (IL-2) were superseded by ICIs. For high-risk, early-stage melanoma, ipilimumab was found to increase the 3-year recurrence-free rate by more than 10%.6

While surgical excision is the primary treatment for non-melanoma skin cancers (NMSCs), immunotherapy has emerged as a promising treatment option in recent years.7 In the case of NMSCs, ICIs are the most commonly used immunotherapy drugs. These drugs block proteins in cancer cells, preventing the immune system from recognizing and attacking them.8 Clinical trials have shown that ICIs such as pembrolizumab and nivolumab have high response rates and durable responses in patients with advanced NMSCs.9 These drugs have been approved by the US Food and Drug Administration for the treatment of metastatic or locally advanced squamous cell carcinoma (SCC) and basal cell carcinoma (BCC), which cannot be treated with surgery or radiation. Other types of immunotherapies for NMSCs include topical immunomodulators such as imiquimod and ingenol mebutate, which stimulate the immune system to attack cancer cells locally.10 Intralesional immunotherapy, which involves injecting an immune-stimulating substance directly into the tumor, is also being investigated as a potential treatment option. For the treatment of cutaneous SCC (cSCC), pembrolizumab and cemiplimab, two single-agent anti-PD-1 inhibitors, exhibited an overall response rate of 42% and 52% in recurrent/metastatic disease and locally advanced disease, respectively, when used as frontline, first-line treatment for advanced or metastatic cSCC that is not responsive to surgery or radiation.11 Both medications had long-lasting effects with manageable side effects. Merkle cell carcinoma (MCC), like cSCC, is a very immunogenic illness and a promising target for immunotherapy based on ICI. In pre-treated patients with advanced MCC, the JAVELIN Merkel 200 study showed that avelumab resulted in a 33.0% overall response rate and a median duration of response of 40.5 months.12 In comparison to cSCC, BCCs are at least two times more prevalent. The metastatic rate for BCCs is less than 1%, which is substantially lower than that for cSCCs and MCCs. Moreover, cemiplimab has been shown to generate a strong antitumor response in patients with locally advanced BCC.13

Biomarkers of response to immunotherapy in melanoma have been studied to help identify patients most likely to benefit from treatment and develop new therapeutic strategies. Programmed death-ligand 1 (PD-L1) is a protein expressed on the surface of some cancer cells, including melanoma.14 It interacts with the programmed death-1 (PD-1) receptor on T cells, inhibiting their activity and preventing the immune system from attacking cancer cells. Tumors with high levels of PD-L1 expression are more likely to respond to PD-1/PD-L1 checkpoint inhibitors. Tumor mutational burden (TMB) measures the number of mutations present in a tumor's DNA. High TMB is associated with an increased likelihood of response to ICIs, as these mutations may generate new tumor antigens that can be recognized by the immune system.15 TMB is naturally elevated in melanoma and correlates with better responses toimmune checkpoint inhibition depending on the severity of cancer. However, it is not regularly used as a predictor of ICI response. Melanoma responds exceedingly well to ICI; hence, a biomarker of ICI resistance may be more important than a biomarker of response in clinical care. Tumor-infiltrating lymphocytes (TILs) are immune cells that have migrated into the tumor microenvironment. Tumors with high levels of TILs are more likely to respond to immunotherapy, as they indicate an ongoing immune response against the tumor.16 The biomarkers of immunotherapy response in melanoma also include immune gene expression profiling and the gut microbiome. Gene expression profiling can be used to assess the activity of immune-related genes within the tumor microenvironment.17 Certain gene signatures have been associated with response to immunotherapy in melanoma. The composition of the gut microbiome has been shown to affect the efficacy of immune checkpoint inhibitors.18 Studies suggest that a more diverse gut microbiome is associated with a better response to immunotherapy.

Biomarkers that can help predict immunotherapy response or resistance in non-melanoma skin cancers include Interferon-gamma (IFN-) signature, Immunoscore, and Circulating tumor DNA (ctDNA). Interferon-gamma (IFN-) signature is a cytokine that plays a vital role in activating the immune system.19 Tumors with a high IFN- signature may be more likely to respond to immunotherapy. The Immunoscore is a measure of the immune cell infiltration and activation within a tumor. A higher Immunoscore may indicate a better response to immunotherapy.20 Circulating tumor DNA (ctDNA) refers to small fragments of DNA that are shed by tumor cells into the bloodstream. The presence of ctDNA may indicate the presence of residual disease, and monitoring ctDNA levels may help predict response to immunotherapy.21

Immunotherapy has revolutionized the treatment of melanoma and non-melanoma skin cancers, and research is ongoing to identify new targets and improve existing therapies. Now considered the gold standard for treating advanced melanoma, immune checkpoint inhibitors (ICIs) have helped improve the treatment and prognosis of patients with a variety of cancers. Median overall survival and a substantial, durable response are achieved with anti-CTLA-4/anti-PD-1 combination therapy. Previous immunostimulatory therapies, such as interleukin-2 (IL-2), have been replaced by immune checkpoint inhibitors in the therapeutic field of melanoma. Patients with advanced NMSCs have shown both a high response rate and long-lasting responses to immune checkpoint inhibitors like pembrolizumab and nivolumab, according to clinical trials. Immunotherapy has been shown to be effective against melanoma, and researchers have been looking at biomarkers of response to better target treatment towards patients suffering from skin cancers. PD-L1 expression, TMB, MSI, TILs, and HPV status have all been identified as potential biomarkers of response to immunotherapy in melanoma and non-melanoma skin cancers. However, additional research is needed to better understand the complex interplay between the tumor microenvironment and the immune system.

References

1. Bagchi S, Yuan R, Engleman EG. Immune checkpoint inhibitors for the treatment of cancer: Clinical impact and mechanisms of response and resistance.Annual Review of Pathology: Mechanisms of Disease. 2021;16(1):223-249. doi:https://doi.org/10.1146/annurev-pathol-042020-042741

2. Kostine M, Rouxel L, Barnetche T, et al. Rheumatic disorders associated with immune checkpoint inhibitors in patients with cancerclinical aspects and relationship with tumour response: a single-centre prospective cohort study.Annals of the Rheumatic Diseases. 2017;77(3):393-398. doi:https://doi.org/10.1136/annrheumdis-2017-212257

3. Hwang JK, Hong J, Yun CO. Oncolytic viruses and immune checkpoint inhibitors: Preclinical developments to clinical trials.International Journal of Molecular Sciences. 2020;21(22):8627. doi:https://doi.org/10.3390/ijms21228627

4. Bence C, Hofman V, Chamorey E, et al. Association of combined PD L1 expression and tumourinfiltrating lymphocyte features with survival and treatment outcomes in patients with metastatic melanoma.Journal of the European Academy of Dermatology and Venereology. 2019;34(5):984-994. doi:https://doi.org/10.1111/jdv.16016

5. Suda K. Recent Advances in cancer immunotherapy.Biomolecules. 2021;11(2):335. doi:https://doi.org/10.3390/biom11020335

6. Zimmer L, Livingstone E, Hassel JC, et al. Adjuvant nivolumab plus ipilimumab or nivolumab monotherapy versus placebo in patients with resected stage IV melanoma with no evidence of disease (IMMUNED): a randomised, double-blind, placebo-controlled, phase 2 trial.The Lancet. 2020;395(10236):1558-1568. doi:https://doi.org/10.1016/s0140-6736(20)30417-7

7. Shalhout SZ, Emerick KS, Kaufman HL, Miller DM. Immunotherapy for non-melanoma skin cancer.Current Oncology Reports. 2021;23(11). doi:https://doi.org/10.1007/s11912-021-01120-z

8. Zelin E, Maronese CA, Dri A, et al. Identifying candidates for immunotherapy among patients with non-melanoma skin cancer: A review of the potential predictors of response.Journal of Clinical Medicine. 2022;11(12):3364. doi:https://doi.org/10.3390/jcm11123364

9. Fahradyan A, Howell AC, Wolfswinkel EM, Tsuha M, Sheth P, Wong AK. Updates on the management of non-melanoma skin cancer (NMSC).Healthcare. 2017;5(4). doi:https://doi.org/10.3390/healthcare5040082

10. Cives M, Mannavola F, Lospalluti L, et al. Non-melanoma skin cancers: Biological and clinical features.International Journal of Molecular Sciences. 2020;21(15). doi:https://doi.org/10.3390/ijms21155394

11. Ascierto PA, Schadendorf D. Immunotherapy in non-melanoma skin cancer: Updates and new perspectives.Drugs in Context. 2019;8:1-6. doi:https://doi.org/10.7573/dic.212583

12. Shalhout SZ, Emerick KS, Kaufman HL, Miller DM. Immunotherapy for non-melanoma skin cancer.Current Oncology Reports. 2021;23(11). doi:https://doi.org/10.1007/s11912-021-01120-z

13. Stratigos AJ, Sekulic A, Peris K, et al. Cemiplimab in locally advanced basal cell carcinoma after hedgehog inhibitor therapy: an open-label, multi-centre, single-arm, phase 2 trial.The Lancet Oncology. 2021;22(6):848-857. doi:https://doi.org/10.1016/s1470-2045(21)00126-1

14. Berghoff AS, Ricken G, Widhalm G, et al. Tumour-infiltrating lymphocytes and expression of programmed death ligand 1 (PD-L1) in melanoma brain metastases.Histopathology. 2014;66(2):289-299. doi:https://doi.org/10.1111/his.12537

15. Jardim DL, Goodman A, de Melo Gagliato D, Kurzrock R. The challenges of tumor mutational burden as an immunotherapy biomarker.Cancer Cell. 2021;39(2):154-173. doi:https://doi.org/10.1016/j.ccell.2020.10.001

16. Paijens ST, Vledder A, de Bruyn M, Nijman HW. Tumor-infiltrating lymphocytes in the immunotherapy era.Cellular & Molecular Immunology. Published online November 2, 2020:1-18. doi:https://doi.org/10.1038/s41423-020-00565-9

17. Farberg AS, Marson JW, Glazer A, et al. Expert consensus on the use of prognostic gene expression profiling tests for the management of cutaneous melanoma: Consensus from the skin cancer prevention working group.Dermatology and Therapy. 2022;12(4):807-823. doi:https://doi.org/10.1007/s13555-022-00709-x

18. Rezasoltani S, Yadegar A, Asadzadeh Aghdaei H, Reza Zali M. Modulatory effects of gut microbiome in cancer immunotherapy: A novel paradigm for blockade of immune checkpoint inhibitors.Cancer Medicine. 2020;10(3):1141-1154. doi:https://doi.org/10.1002/cam4.3694

19. Bridge JA, Lee JC, Daud A, Wells JW, Bluestone JA. Cytokines, chemokines, and other biomarkers of response for checkpoint inhibitor therapy in skin cancer.Frontiers in Medicine. 2018;5. doi:https://doi.org/10.3389/fmed.2018.00351

20. Bruni D, Angell HK, Galon J. The immune contexture and Immunoscore in cancer prognosis and therapeutic efficacy.Nature Reviews Cancer. Published online August 4, 2020:1-19. doi:https://doi.org/10.1038/s41568-020-0285-7

21. Cabel L, Riva F, Servois V, et al. Circulating tumor DNA changes for early monitoring of anti-PD1 immunotherapy: a proof-of-concept study.Annals of Oncology. 2017;28(8):1996-2001. doi:https://doi.org/10.1093/annonc/mdx212

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The Future of Immunotherapy Targets - Dermatology Times

Rx Dermatology Topical Drug Delivery Market is Progressing at a CAGR of 4.5% till 2028 – openPR

Rx Dermatology Topical Drug Delivery Market

The Rx dermatology topical drug delivery market is expected to witness market growth at a rate of 4.5% in the forecast period of 2021 to 2028. Data Bridge Market Research report on Rx dermatology topical drug delivery market provides analysis and insights regarding the various factors expected to be prevalent throughout the forecast period while providing their impacts on the market's growth. The rapid advancements in the healthcare sector globally is escalating the growth of Rx dermatology topical drug delivery market.

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The research provides information on the most accurate revenue predictions for the overall market and its sectors in order to help market leaders and new entrants. The purpose of this study is to better understand the competitive environment so that stakeholders can build appropriate go-to-market strategies. The market size, characteristics, and growth of the Rx Dermatology Topical Drug Delivery industry are broken down in this report by type, application, and consumption area. Additionally, the effectiveness of key market segments, such as cost of manufacturing, dispatch, application, volume of usage, and arrangement, is evaluated.

The widespread Rx Dermatology Topical Drug Delivery report has been built with the appropriate expertises that utilize established and unswerving tools and techniques such as SWOT analysis and Porter's Five Forces analysis to conduct the research study. To attain knowhow of market landscape, brand awareness, latest trends, possible future issues, industry trends and customer behaviour, this premium market research report is very crucial. The report also identifies and analyses the intensifying trends along with major drivers, challenges and opportunities in the market. An excellent Rx Dermatology Topical Drug Delivery market report is a source of information about Healthcare industry which puts forth current and upcoming technical and financial details of the industry to 2029.

Competitive Outlook:

The report also includes company profiles, revenue sharing, and SWOT analysis of the key participants in the Rx Dermatology Topical Drug Delivery Market. You may keep one step ahead of the competition by using the Rx Dermatology Topical Drug Delivery industry research, which provides a complete assessment of the crucial factors that are changing. The drivers, restraints, weaknesses, opportunities, and threats in the global market can all be found using these market measurement techniques.

The market size, revenue generated from the sales and technologies by various application segments are properly evaluated in the large scale Rx Dermatology Topical Drug Delivery market survey report. The market research report includes a thorough analysis of the market drivers, restraints, threats, and opportunities while it also addresses the lucrative investment options for the market players in the coming years. Estimates at a global as well as regional level are offered by the analysts. The industry report compiles comprehensive intelligence studies that explore almost every aspect of the global market. The data and information is extensively researched and analyzed in the global Rx Dermatology Topical Drug Delivery business report to direct market players to improve their business planning and ensure long-term success.

Key companies operating in the market are:

Galderma Laboratories, L.P.Hisamitsu Pharmaceutical Co., Inc.Pfizer Inc.LEO Pharma A/SGlaxoSmithKline plc.ALLERGANBayer AG3MBausch Health Companies Inc.The Lubrizol CorporationCipla Inc.Kaken Pharmaceutical Co., Ltd.

Market Overview:

This market study has all the data you require to launch or expand your company in this sector. Along with price and emerging market structure, it also provides market drivers, restraints, competition, and regional estimates. The business model, benchmarks, consumer preferences, value proposition, and net profit of an organisation are all fully described. This thorough Rx Dermatology Topical Drug Delivery market analysis also clarifies important methods that support businesses in accurately determining the purchasing patterns of their clients.

Report Coverage:

We offer our reports, which are conducted using a thorough evaluation methodology that places a strong emphasis on supplying accurate information. Our researchers have used a data triangulation technique, which helps us even more in providing precise estimation and thoroughly testing the general market dynamics. Additionally, in order to provide stakeholders and business experts with the most current information, our analysts have been granted admission to various geographically and globally financed registers.

Browse Complete Reports Along with Facts and Figures of Rx Dermatology Topical Drug Delivery Market @ https://www.databridgemarketresearch.com/reports/global-rx-dermatology-topical-drug-delivery-market

Drivers and Restraints:

The Rx Dermatology Topical Drug Delivery market drivers are acknowledged for their aptitude to show how their actions can affect the market's overall expansion over the course of the predicted period. In order to identify potential emerging trends in the industry, a thorough examination of the significance of the driving forces and potential barriers that market participants may encounter in the Rx Dermatology Topical Drug Delivery market is undertaken. The limitations of the Rx Dermatology Topical Drug Delivery market may draw attention to issues that could impede the expansion of the rising market. Businesses should be able to widen their solutions to problems as a result of understanding the negative aspects of the Rx Dermatology Topical Drug Delivery market, which will increase their ability to influence the pessimistic outlook.

Market Opportunities:

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Utilize current information gathered by our own researchers. This gives you access to historical and projected data that is analysed to reveal the reasons the Rx Dermatology Topical Drug Delivery industry is changing; this enables you to foresee market changes and preserve a competitive advantage.

The clear graph, succinct analysis, and table style make it easy to get the data you need.

Defines the region and market sector most likely to see rapid growth and market dominance.

A geographical analysis showing the factors influencing the market in each region as well as how the product or service is used there.

Detailed company profiles for the major market players, including executive summaries, corporate insights, product benchmarking, SWOT analysis, and information on recent service/product launches, business expansions, and acquisitions by the companies profiled.

A forecast of the market for the sector's current and upcoming years that takes into consideration recent changes, such as growth prospects, drivers of that growth, and challenges and constraints in both emerging and developed economies.

Provides information on potential future market growth as well as industry knowledge through a Value Chain - Market Dynamics scenario.

TOC in Brief:

1 INTRODUCTION2 MARKET SEGMENTATION3 EXECUTIVE SUMMARY4 PREMIUM INSIGHTS5 REGULATORY FRAMEWORKS

Continued..

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What Does This Report Provide:

What will be the size of the markets and the pace of growth in 2029? What is the anticipated rate of growth for the Rx Dermatology Topical Drug Delivery market? How big will the Rx Dermatology Topical Drug Delivery market be during the projection period? What are the main driving factors that have altered the course of the Rx Dermatology Topical Drug Delivery industry? Which key vendors are leading the Rx Dermatology Topical Drug Delivery industry in various regions? How do they beat the competition by using winning strategies? What threats and obstacles are anticipated to impede the development of the Rx Dermatology Topical Drug Delivery sector in various nations? What are the main chances that entrepreneurs can count on for the foreseeable future? What are the key conclusions of the five-point analysis of the Rx Dermatology Topical Drug Delivery market?

A complete overview of the Healthcare industry has been offered via Rx Dermatology Topical Drug Delivery Market document which considers various aspects of product definition, market segmentation, and the existing retailer landscape. This market research report is formulated by using integrated advancements and latest technology to obtain the most excellent results. This market research report encompasses various parameters of the market. These parameters range from industry outlook, currency and pricing, value chain analysis, market overview, premium insights, key insights to the company profile of the key market players. It becomes easy to create sustainable and profitable business strategies by using valuable and actionable market insights included in the winning Rx Dermatology Topical Drug Delivery Market report.

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Data Bridge Market Research Pvt Ltd is a multinational management consulting firm with offices in India and Canada. As an innovative and neoteric market analysis and advisory company with unmatched durability level and advanced approaches. We are committed to uncover the best consumer prospects and to foster useful knowledge for your company to succeed in the market.

Data Bridge Market Research is a result of sheer wisdom and practice that was conceived and built-in Pune in the year 2015. The company came into existence from the healthcare department with far fewer employees intending to cover the whole market while providing the best class analysis. Later, the company widened its departments, as well as expands their reach by opening a new office in Gurugram location in the year 2018, where a team of highly qualified personnel joins hands for the growth of the company. "Even in the tough times of COVID-19 where the Virus slowed down everything around the world, the dedicated Team of Data Bridge Market Research worked round the clock to provide quality and support to our client base, which also tells about the excellence in our sleeve."

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Rx Dermatology Topical Drug Delivery Market is Progressing at a CAGR of 4.5% till 2028 - openPR

The Global Dermatology EMR Software Market Size, Share and Demand Expected to Increase USD 248.1 Mn By 2032 – EIN News

Dermatology EMR Software Market

The Global Dermatology EMR Software Market Size Is Estimated To Be Worth Usd $ 176.4 Mn In 2023 And Is Forecast To A Readjusted Size Of Usd $ 248.1 Mn By 2032

The Global Dermatology EMR Software Market Size Is Estimated To Be Worth Usd $ 176.4 Mn In 2023 And Is Forecast To A Readjusted Size Of Usd $ 248.1 Mn By 2032 With A Cagr Of 3.5% Over The Forecast Period 2023-2032.

The Advancements In Technology Have Revolutionized The Healthcare Industry, And Nowhere Is This More Apparent Than With Dermatology Emr Software. Electronic Medical Record (Emr) Software Has Made It Simpler For Dermatologists To Keep Their Patient Records Organized And Secure. This Makes It Easier For Dermatologists To Access A PatientS Medical History, Document Treatments, And Make Informed Decisions About Care. With An Emr System, Dermatologists Can Save Time On Paperwork While Providing Better Quality Care.

The Dermatology Emr Software Market Is A Rapidly Growing Sector Of The Medical Technology Industry. Recent Advancements In Electronic Medical Record (Emr) Systems Have Enabled Dermatologists To Better Manage Patient Information And Provide Improved Care. With The Demand For High-Quality Dermatology Services On The Rise, The Global Dermatology Emr Software Market Is Projected To Experience Significant Growth Over The Next Five Years. The Global Healthcare Industry Is Rapidly Changing Due To The Development Of Advanced Technology. One Of Those Advancements Is The Use Of Electronic Medical Records (Emr) Software In Dermatology Practices. Dermatology Emr Software Automates And Streamlines Many Processes That Are Traditionally Managed By Paper Or Other Electronic Systems. This Article Will Explore The Market Opportunity For Dermatology Emr Software, Including Its Potential For Cost Savings, Improved Patient Care, And Increased Practice Efficiency.

The Latest Research On The Global Dermatology Emr Software Market Report Covers Forecast And Top To Bottom Analysis On A Worldwide, Country, And Regional Level. The Study Report Provides Historical Information For 2016-2023 Together With A Forecast From 2023 To 2032 Supported By Both Volume And Revenue (Usd Million). The Whole Study Covers The Key Drivers And Restraints Of The Dermatology Emr Software Industry. Especially This Report Included A Unique Section On The Impact Of Covid-19. Also, Dermatology Emr Software Market (By Major Key Players, By Types, By Applications, And Leading Regions) Segments Outlook, Business Opportunities, Competition Scenario, And Futuristic Trends.

Our Analytics Team Has Deliberately Performed Quantitative And Qualitative Assessments Of The Dermatology Emr Software Market Dynamics, Considering A Slew Of Features, Including Market Penetration, Portfolios, End-User Industries, Pricing Structure And The Key Drivers, Restraints, Opportunities, And Challenges Mostly Affecting Dermatology Emr Software Market Growth.

Our Report Will Help You Find What You Looking for. Get a Request Sample PDF Copy Of The Report @https://market.biz/report/global-dermatology-emr-software-market-gm/#requestforsample

This Dermatology EMR Software Market Report Has Provided In-Depth Information On Leading Future Trends, Growth Factors, Consumption, Production Volume, Cagr Value, Attentive Opinions, Margin Of Profit, Price, And Industry-Validated Market Data, Among Other Things, Included Within The Research Report. Especially Individuals And Market Competitors Can Use This Report To Forecast Future Profitability And Make Critical Business Decisions.

Global Dermatology EMR Software Market Segmentation Analysis

The Market Research Report Includes Information On Dermatology EMR Software Market Regions And Nations. Estimates Are Made For Deals Volume, Mass Production, Consumption, Imports, And Exports. Product Type, Function, End-Use, And Landscape Are The Major Industry Segments. This Study Explores Each Of The Major Parts And Each Of the Sub-Segments In An Order To Completely Comprehend The Market.

Global Dermatology EMR Software Market By Type

The Research Report Analyzes Essential Elements Like Production, Revenue, Price, Size, Advancement, Future Forecast, And Market Rate Of Growth Of Each Type, Primarily Split Into

Cloud Based On Premise

Global Dermatology EMR Software Market By Application

The Research Report Analysis The Market Segmentation, Regional Analysis, Manufacturer Overview, And Prime Applications/End Users:

Hospital Clinic Private

Global Dermatology EMR Software Market Competitor Overview

AdvancedMD DrChrono EHR athenahealth EHR Kareo Clinical EHR PrognoCIS by Bizmatics Compulink Healthcare Solutions Practice Fusion ChARM EHR Modernizing Medicine MDConnection patientNOW Greenway Health NovoClinical eClinicalWorks Nextech Harmony e/Notes TotalMD Advanced Data Systems

Regional AnalysisDermatology EMR Software Market

The Global Dermatology EMR Software Market Report Also Encompasses The Regional Analysis To Offer The Complete Regional Development Status. Additionally, The Report Also Provides Necessary Recommendations And Suggestions For The Dermatology EMR Software Market Players So As To Attain A Competitive Edge In Various Regions. It Also Provides Market Size And Forecast Estimates From the Year 2023 To 2032 With Reference To Five Major Regions,

North America Europe Asia Pacific Latin America The Middle East and Africa

Buy This Premium Report @:

https://market.biz/checkout/?reportId=572427&type=Single%20User

Covid-19 Impact Analysis

Along With The Unique Coronavirus (Covid-19), Problem Expands Around The World, We Regularly Analyze Dermatology EMR Software Market Shifts And Customer Behavior. We Also Consider The Consequences Of The Epidemic While Forecasting Present-Day Industry Trends And estimates. This Material May Be Useful To Industry Partakers Who Are Putting Together Strategies For Epidemic-Suchlike Events.

Major Factors Covered Within The Research Report:

1)The Report Provides All The Vital And Accurate Figures Required To Realize a Better Understanding Of The Market Revenue, Share, And Volume.

2)Industry Overview, Market Strategies, Costing Analysis, Competitive Landscape, Consumption Rate, And Import/Export Details.

3)A Complete Detail Of The Growth Rate Over The Forecast Period Is Described In The Dermatology EMR Software Market Report.

4)All The Aspects Including Market Geographical Development Status And Industry Competitiveness Also Are Presented In The Statistical Format.

5)Other Essential Data Including Risks, Opportunities, Latest Developments, Challenges, And Future Scope Of The Market Are Accurately Covered Within The Report.

6)The Report Covers Key Growth Stimulators, Statistical Data, And Business Strategies Which Will Help Market Key Players Take Crucial Business Decisions.

*Key Questions Answered In This Report

1. What's The Total Market Value Of the Dermatology EMR Software Market Report?

2. What's The Impact Of Post Covid-19 Scenario On the Dermatology EMR Software Industry?

3. How Can I Get Sample Reports/Company Profiles Of Dermatology EMR Software?

4. What Are The Upcoming Trends In Dermatology EMR Software Industry?

5. What Are The Key Strategies Adopted By The Top Players To Increase Their Revenue In Dermatology EMR Software?

6. How Can I Get Sample Reports/Company Profiles Of Dermatology EMR Software?

7. Which Region Is And Can Provide More Business Opportunities For Dermatology EMR Software In the Future?

8. Which Is The Most Influencing Segment Growing In The Dermatology EMR Software Report?

9. Which Are The Key-Matured Markets Growing Within The Dermatology EMR Software Report?

For Inquiry Or Customization On This Dermatology EMR Software Market Report:

https://market.biz/report/global-dermatology-emr-software-market-gm/#inquiry

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The Global Dermatology EMR Software Market Size, Share and Demand Expected to Increase USD 248.1 Mn By 2032 - EIN News