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Studies have shown many times over that people with a family history of alcoholism may be predisposed to be at a greater risk of developing drinking problems. But what if genetics also impacts how you remember hangovers? At Keele University, psychologist Dr. Richard Stephens looked into exactly that.

The National Institute on Alcohol Abuse and Alcoholism has reported that people with a family history are four times more likely to develop a drinking problem. Stephens based his research on that statistic, but focusing more on whether hangovers have some sort of impact on this.

More:Dispatches From High School: Teens on Drinking Alcohol

Stephens and his team conducted two studies to test this theory. His first study included 142 people, with a small portion of them having a family history of problem drinking, where he had them complete a survey about their hangovers in the past year. This study found that those with alcoholism in their family background recalled more frequent hangover symptoms than those who didnt have any family history of problem drinking.

His second study was designed in the same way, except the participants were asked about hangover symptoms the morning directly after a night of drinking. The results showed that there were no greater signs of hangover symptoms in the participants with a family history of alcoholism than in those who did not.

More:Alcohol Is Never an Excuse For Sexual Assault Period

While the findings may seem cloudy, Stephens is relatively positive toward his research. To him, it seemed that people who [were] predisposed to develop problem drinking are no more susceptible to developing a hangover however, we found that such people appear to remember their hangovers more lucidly.

So, while the amount of hangovers experienced did not change, the results showed that individuals who have a family history of problem drinking or alcoholism are more clearly able to remember their hangovers or what those hangovers felt like than those who do not have that kind of background. Stephens hopes that this information can be used to help curb excessive drinking and facilitate the means to create programs or plans for managing alcohol consumption.

More:My Spouse and I Quit Drinking and It Changed Our Relationship

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How You Remember This Weekend's Hangover Will Depend Genetics - SheKnows.com

In this photo taken Nov. 2009, central Illinois corn farmers harvest their crops near Waverly, Ill. While a Senate vote to end a tax credit that's helped build the ethanol industry in the United States signals that the subsidy's days may be numbered, corn farmers and ethanol makers hope they can convince Congress to compromise and agree to preserve but reduce subsidies. But agricultural economists say the ethanol industry has grown up over the last few years and doesn't need the help, and they doubt farmers or their customers in the ethanol industry would be hurt much if the subsidy dies. (AP Photo/Seth Perlman)

CELINA Two seed industry experts, Max Bixler and Gregg Adams, have launched a new company, B&A Genetics. The company will serve farmers in Indiana, Ohio and Illinois, and offers a diverse portfolio of the newest, elite germplasm, as well as a customized, one-on-one approach to help farmers simplify their operations and increase crop yields.

Bixler and Adams have more than 15 years of experience in the seed industry.

For more information about B&A Genetics, call 419-305-5481 or visit http://bagenetics.us.

In this photo taken Nov. 2009, central Illinois corn farmers harvest their crops near Waverly, Ill. While a Senate vote to end a tax credit that's helped build the ethanol industry in the United States signals that the subsidy's days may be numbered, corn farmers and ethanol makers hope they can convince Congress to compromise and agree to preserve but reduce subsidies. But agricultural economists say the ethanol industry has grown up over the last few years and doesn't need the help, and they doubt farmers or their customers in the ethanol industry would be hurt much if the subsidy dies. (AP Photo/Seth Perlman)

http://limaohio.com/wp-content/uploads/2017/03/web1_Harvest.jpgIn this photo taken Nov. 2009, central Illinois corn farmers harvest their crops near Waverly, Ill. While a Senate vote to end a tax credit that's helped build the ethanol industry in the United States signals that the subsidy's days may be numbered, corn farmers and ethanol makers hope they can convince Congress to compromise and agree to preserve but reduce subsidies. But agricultural economists say the ethanol industry has grown up over the last few years and doesn't need the help, and they doubt farmers or their customers in the ethanol industry would be hurt much if the subsidy dies. (AP Photo/Seth Perlman)

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Celina seed industry veterans launch new company, B&A Genetics - Lima Ohio

March 30, 2017

Researchers at Case Western Reserve University School of Medicine have successfully grown stem cells from children with a devastating neurological disease to help explain how different genetic backgrounds can cause common symptoms. The work sheds light on how certain brain disorders develop, and provides a framework for developing and testing new therapeutics. Medications that appear promising when exposed to the new cells could be precisely tailored to individual patients based on their genetic background.

In the new study, published in The American Journal of Human Genetics, researchers used stem cells in their laboratory to simultaneously model different genetic scenarios that underlie neurologic disease. They identified individual and shared defects in the cells that could inform treatment efforts.

The researchers developed programmable stem cells, called induced pluripotent stem cells, from 12 children with various forms of Pelizaeus-Merzbacher Disease, or PMD. The rare but often fatal genetic disease can be caused by one of hundreds of mutations in a gene critical to the proper production of nerve cell insulation, or myelin. Some children with PMD have missing, partial, duplicate, or even triplicate copies of this gene, while others have only a small mutation. With so many potential causes, researchers have been in desperate need of a way to accurately and efficiently model genetic diseases like PMD in human cells.

By recapitulating multiple stages of the disease in their laboratory, the researchers established a broad platform for testing new therapeutics at the molecular and cellular level. They were also able to link defects in brain cell function to patient genetics.

"Stem cell technology allowed us to grow cells that make myelin in the laboratory directly from individual PMD patients. By studying a wide spectrum of patients, we found that there are distinct patient subgroups.

This suggests that individual PMD patients may require different clinical treatment approaches," said Paul Tesar, PhD, study lead, Dr. Donald and Ruth Weber Goodman Professor of Innovative Therapeutics, and Associate Professor of Genetics and Genome Sciences at Case Western Reserve University School of Medicine.

The researchers watched in real-time as the patients' stem cells matured in the laboratory. "We leveraged the ability to access patient-specific brain cells to understand why these cells are dysfunctional. We found that a subset of patients exhibited an overt dysfunction in certain cellular stress pathways," said Zachary Nevin, first author of the study and MD/PhD student at Case Western Reserve University School of Medicine. "We used the cells to create a screening platform that can test medications for the ability to restore cell function and myelin. Encouragingly, we identified molecules that could reverse some of the deficits." The promising finding provides proof-of-concept that medications that mend a patient's cells in the laboratory could be advanced to clinical testing in the future.

The stem cell platform could also help other researchers study and classify genetic diseases with varied causes, particularly other neurologic disorders. Said Tesar, "Neurological conditions present a unique challenge, since the disease-causing cells are locked away in patients' brains and inaccessible to study. With these new patient-derived stem cells, we can now model disease symptoms in the laboratory and begin to understand ways to reverse them."

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Stem cells help explain varied genetics behind rare neurologic disease - Medical Xpress

THE signing this month by the United States of an international treaty facilitating access to crop genetic resources will enhance the ability of Australian plant breeders to develop improved lines for Australian farmers.

Kent Nnadozie

The International Treaty on Plant Genetic Resources for Food and Agriculture, which was ratified by Australia in 2006, is an international instrument that Australian farmers and plant breeders rely heavily on to access the raw genetic material needed to develop new crop varieties.

Secretary of the Treaty, Kent Nnadozie, is visiting Canberra this week to meet with government, industry and other stakeholders to discuss the planned enhancement of Treaty systems which are expected to further benefit Australian farmers and breeders.

Australian farmers can be very pleased with this months signing by the United States of the Treaty, Mr Nnadozie said.

The more countries we have on board with our efforts for a globe-spanning collection of plant genetic resources, the better for all farmers, wealthy or not and in direct competition or not.

All farmers need plant genetic material for use in research, breeding and training efforts, which also includes measures to ensure the fair and equitable sharing of financial benefits.

This material is vital to Australia as over 95 per cent of Australian agriculture is based on plant genetic resources from other countries.

Mr Nnadozie said the Treatys Multilateral System currently covered over 1.5 million crop samples of plants, seeds and crop and applied to 64 foods, feeds and grazing crops maintained by International Agricultural Research Centres or under the management and control of national governments and in the public domain.

Australia has much in common with developing countries in their battle with ecological and climatic challenges, he said.

Most Australian and US farmers have the benefit of the latest science, mechanisation and worlds best extension services, not necessarily available to their developing country cousins. But farmers the world over benefit from the preservation of crop diversity and varieties adapted to emerging and future climate conditions.

This is particularly the case now that the worlds agriculture is dangerously reliant on a narrow genetic base of a limited number of food crops, and climate change expected to profoundly alter the conditions of agriculture.

Australias special support for the Treatys systems benefiting farmers, breeders and researchers in the Pacific is particularly welcome as these farmers face significant issues around food security and climate change.

Mr Nnadozie said Australia had contributed A$2 million to the Treatys Benefit-sharing Fund since 2010, which supported high impact projects aimed at helping farmers in developing countries achieve food security and adapt to climate change.

Projects have supported the development, testing and use of climate ready crop varieties, including the conservation and use of indigenous food crops.

These new crop varieties are also made available to others under the Treatys Multilateral System for further research and breeding.

The development of varieties with greater tolerance to extreme temperatures, drought and flooding, as well as resistance to pests and disease is key in the context of climate change, Mr Nnadozie said.

Adaption breeding will increasingly require access to appropriate crop genetic resources from outside national borders, and the Treaty facilitates this.

The Treaty, which has membership of 143 countries, offers considerable benefits to Australian farmers and commercial breeding enterprises through providing greater access and stability to global genetic resources under standard agreed terms.

The enhancement of the Treatys systems will further expand free open access to more material and facilitate the development of more climate ready crops, Mr Nnadozie said.

Source: The Crawford Fund, http://www.crawfordfund.org

The Crawford Funds mission is to increase Australias engagement in international agricultural research, development and education for the benefit of developing countries and Australia.

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US joins treaty to expand access to global crop genetics - Grain Central (registration) (blog)

Dairy farmer John P. Galvin milks 80 cows in a compact spring-calving system overlooking the Dingle Peninsula in Lispole, Co. Kerry.

Galvins land goes right down to the Atlantic Ocean and receives 1,600-1,700mm of rainfall on an annual basis.

Last year, John sold 477kg of milk solids from each cow in his herd to the Kerry Group at 4.22% fat and 3.62% protein.

This output per cow, combined with the high percentages, resulted in a high milk price and helped John greatly in the difficult year that 2016 was.

The herd also featured in the recent top 200 EBI herds in Ireland, sitting in 149th place, with a herd EBI of 129. The herds EBI is balanced between milk (44), fertility (51) and calving (33).

John uses the Munster AI technician service and combines the fresh semen programme with the year one genomic tested sires.

The AI technician, via his handheld, ensures that no inbreeding occurs.

This service allows John to concentrate solely on heat detection during the breeding season knowing that he is receiving the very best genetics available, from a highly skilled Munster AI technician, and completely avoiding inbreeding.

The genetic progress being made is evident from the EBI graph.

The fertility performance of the herd is impressive, with over 85% of the herd calving in just six weeks.

This is achieved through a high submission rate, due to excellent heat detection and a high conception from the AI technician.

Johns heat detection is exceptional; scratch cards are used on the heifers. Cows not detected in heat three weeks into the breeding season are examined and treated.

John monitors the health status of his herd and the efficacy of his vaccination and parasite control programme annually, through the Munster Herd Health programme.

He finds the end-of-year meeting with the Munster vet invaluable, for reviewing his performance and helping him with decisions in which he plans the dry period and the year ahead.

For the past two years, he has carried out Johnes Disease screening through milk recording.

Both these programmes ensure that output is maintained each year and that high genetic breeding stock, with a high health status, can be sold off the farm.

The Kerry-based dairy farmer attributes the performance of his herd to their genetics, health and a compact spring-calving pattern.

Performance is monitored by monthly milk recording from February to November. John is now firmly of the opinion that each cow needs to be contributing to the bottom line for him to maximise his profitability.

The real profit drivers are the mature third lactation plus cows, calving in February.

In 2016, the top 10 mature cows averaged 7,300kg of milk, with 569kg of milk solids at 4.14% fat and 3.65% protein.

A feature of the herd is the consistent level of production between the cows, with no poor performers.

The first milk recording of 2017 was completed on March 7. This allows the early identification of any SCC issues andtheir immediate correction.

This, in turn, allows all cows to reach their full potential over the lactation period.

As all cows and heifers are bred to dairy sires, John has surplus heifers to sell each year as calves, maidens or in-calf heifers.

One can have confidence that these high genetic merit heifers from a high health status herd will perform and remain in the herd for a long time for their new owners.

John has bred a few bulls that have entered AI; the most popular being JKF (IG) Doonmanagh Jacko an FLT son from a great DEU cow.

He is looking forward to producing a genetic gem from his herd on the Dingle peninsula an area that has produced so many footballing legends down through the years.

To find out more about the services offered by Munster AI: Click Here

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Combining genetics, herd health and compact calving on a Co. Kerry dairy farm - Agriland

Press Release CRV Ambreed

CRV Ambreed has made a genetic discovery that it anticipates will result in a more sustainable dairy industry and potentially reduce nitrogen leaching on New Zealand farms by 20% within 20 years.

Media release

Embargoed to 9am 29 March 2017

Breakthrough genetics looking at cutting nitrogen leaching by 20% in NZ CRV Ambreed

CRV Ambreed has made a genetic discovery that it anticipates will result in a more sustainable dairy industry and potentially reduce nitrogen leaching on New Zealand farms by 20% within 20 years.

In whats thought to be an international first, the dairy herd improvement company has announced it will market bulls that are desirable for traditional traits as well as being genetically superior for a new trait that is related to urea nitrogen in milk.

CRV Ambreed is now selling semen from bulls whose daughters will have reduced concentration of Milk Urea Nitrogen (MUN) under a LowN Sires brand. MUN is a measure of the amount of nitrogen contained as milk urea, and CRV Ambreed R&D Manager Phil Beatson says theres overwhelming international evidence of a direct connection between MUN and the amount of nitrogen excreted in urine when fed different diets.

If this connection carries over, cows bred for lower levels of MUN are expected to excrete less nitrogen in their urine which will, in turn, reduce the amount of nitrogen leached from grazed pasture, Mr Beatson says. Daughters of CRV Ambreeds 2017 LowN Sires could potentially save New Zealand 10 million kilograms in nitrogen leaching a year, based on a national herd number of 6.5 million dairy cattle. He says CRV Ambreeds projections indicate that its possible to breed cattle that will reduce nitrogen leaching by 20% within 20 years.

CRV Ambreed Managing Director Angus Haslett says the firm has been researching the connection between MUN and nitrogen in urine for five years. The link between MUN and lower nitrogen output has been acknowledged before in international research, but this is the first time in the world that genetics for low MUN is being marketed with the aim being to reduce nitrogen leaching.

Hundreds of thousands of straws of semen from a team of more than 20 existing top-performing bulls with desirable genetic makeup for low levels of MUN, known as LowN Sires, are already available for use in 2017.

Mr Haslett says this is a continuation of CRV Ambreeds ongoing work to breed for particular traits that improve New Zealands dairy herds for health and environmental reasons. The future is about using genetics for better breeding and CRV Ambreed has been operating in the future for some time. Farmers are already using genetics to breed cows that are more tolerant to Facial Eczema and for breeding polled calves that will not need costly and time-consuming de-budding.

He says while there is a vast amount of research being conducted and proposed in New Zealand to mitigate nitrogen leaching, it makes sense to look at breeding cows that produce less nitrogen from economic and environmental viewpoints. CRV Ambreed will be the first organisation in New Zealand and possibly the world to provide a long-term genetic solution to nitrogen leaching by identifying and selecting bulls for low MUN genes.

Genetics can produce great gains for farmers, he says. Farmers already choose CRV Ambreed bulls to breed certain traits in their cows, so this is another step on that journey of finding solutions in genetics.

Mr Haslett says there is still research to be done to further test and confirm the genetic development and CRV is working with DairyNZ, AgResearch and Lincoln University on this. CRV Ambreed is very positive about the potential benefits the discovery will deliver for farmers and the nation.

The genetic announcement has been welcomed by major industry players such as DairyNZ. DairyNZ Strategy and Investment Leader for Productivity, Dr Bruce Thorrold, says the potential for farmers to reduce nitrogen leaching by breeding cows with lower urinary nitrogen output is exciting.

If the planned science proves the link between breeding for MUN and urinary nitrogen output, this would give farmers in nitrogen-limited regions such as Canterbury more options to reduce nitrogen leaching without going away from a pasture-based system. Animal breeding would potentially add to gains from DairyNZ investment in research on managing nitrogen inputs, using stand-off and finding plants with lower nitrogen content.

CRV Ambreed has already briefed some of New Zealands regional councils about the discovery as many regional councils are working with farmers to minimise nitrogen leaching.

For more information, visit http://www.crv4all.co.nz/lownsires

About CRV Ambreed:

CRV Ambreed has an overarching ethos of better cows, better life and its business is built around one goal: helping its customers achieve their highest performing herd possible. The company proactively manages ongoing changing market demands by offering innovative solutions tailored to customers needs.

Content Sourced from scoop.co.nz Original url

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Breakthrough genetics looking at cutting nitrogen leaching - Scoop.co.nz (press release)

A few US shale oil producers are using DNA sequencing to identify promising wells, Reuters reports. It adds that it's part of companies' efforts to cut costs and keep pace with global oil producers.

The companies are testing DNA extracted from microorganisms found in rock samples to compare to DNA found in oil samples. Similarities and differences in their genetic profiles are then used to find locations that are more likely to have oil.

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Genetics of Oil Drilling - GenomeWeb

Hundreds of thousands of people in the United States are living with a brain tumor. Gliomas are a particular category of malignant brain tumor that includes glioblastoma - a tumor with a low survival rate. New research uncovers genetic variants associated with an increased risk of glioma.

A new genetic study carried out by a team of international researchers from the United Kingdom, Europe, and the U.S. identifies 13 new genetic errors that correlate with a high risk of glioma. The findings were published in the journal Nature Genetics.

The National Brain Tumor Society estimate that 688,096 U.S. individuals have a brain tumor, and nearly 140,000 of these are malignant.

Brain tumors are quite aggressive and difficult to treat, with an average of only 34.4 percent of the patients surviving 5 years after their initial diagnosis.

Of the different types of brain tumor, glioma is the most common. It describes a type of tumor that grows from the brain's glial cells, which can be found around the neurons, supporting the nerve cells.

Across all brain tumors, gliomas account for approximately 27 percent and are estimated to cause 13,000 yearly cancer deaths in the U.S., according to research quoted in the new study. Gliomas are usually divided into glioblastomas (GBMs) and non-GBM tumors. Patients diagnosed with GBMs have a survival rate as low as 5 percent.

The authors of the new study note that little is known about the environmental factors that contribute to the risk of being diagnosed with glioma. The researchers set out to examine the genetic background for glioma risk.

The team conducted two new genomic studies and added their findings to that of previously existing studies. The result was a meta-analysis of almost 12,500 people with glioma and more than 18,000 healthy, glioma-free controls.

Overall, the scientists identified 13 new genetic variants that raised the risk of glioma: five new loci were identified for GBM, and eight for non-GBM tumors. The study shows that these genetic errors impact various cell functions, including the genesis and division of neurons, cell cycle regulation, DNA repair, and the production of some proteins.

Additionally, the scientists examined how different genetic strands affect a person's chances of developing GBM and non-GBM tumors.

For instance, they found that the expression of the HEATR3 gene increases the risk of GBM by 18 percent, but it has a much lower impact on non-GBM risk.

Study co-leader Richard Houlston, professor of molecular and population genetics at the Institute of Cancer Research in London in the U.K., comments on the significance of these findings:

"The changes in the way we think about glioma could be quite fundamental," Prof. Houston explains. "So for example, what we thought of as two related subtypes of the disease turn out to have quite different genetic causes which may require different approaches to treatment."

Apart from the newly discovered genetic errors, the study also confirmed the role of other genes that have been previously identified and correlated with the risk of brain and other types of cancer.

Before the new study, the total number of genetic variants linked to glioma risk was 13. The new research doubles this number.

"It has been exciting to have been involved in such a gigantic study including cases of brain cancer from all over the world. We have uncovered a treasure trove of new information about the genetic causes of glioma brain cancers.

Understanding the genetics of glioma in such detail allows us to start thinking about ways of identifying people at high inherited risk, and will open up a search for new treatments that exploit our new knowledge of the biology of the disease."

Prof. Richard Houlston

Learn how scientists inhibit brain tumor cell growth and how it could pave the way for new treatment.

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Large-scale study finds genetic errors associated with brain cancer - Medical News Today

The technicals for Cancer Genetics, Inc. (CGIX) have taken shape, and with them a comprehensive picture has emerged. This is the current state of play as presented by the current technical setup. Reading the technical chart for a given stock is a vital part of trading and investing success. Unless ample attention is paid to key technical aspects of a stocks pricing and volatility, decisions can at best be considered blind, or worse, idiotic. Getting to grips with all the technical factors that affect price and movement is therefore crucial.

(CGIX) has shown a marked change in trend levels over the course of recent market activity. Based on recent activity surrounding both the 50 and 200 SMAs, theres been a marked trend created which can be described as bullish. The composite picture painted by the trends built around both SMAs has also created a measured analysis of current investor sentiment as the stock navigates upside and downside risk. The established market sentiment toward the stock has created a trading environment which can suitably be described as positive. There has also been a knock-on effect as it relates to trading volume now reflected in strong real-time sentiment on the buying and selling curve; this has created in turn, enthusiasm toward the stock as measured across a broad statistical mix of the general trading community.

As a composite and comprehensive tableau, the stocks position in the minds of the trading market reflects a broad analysis of technicals and inherent trends which underpin overall market-trading viability.

Relative strength indicator (RSI) and Stochastic measures are two very important leading indicators that help traders gauge overall movement of a particular stock; they act as boosters to technical analysis. Together they show in a measured way, whether or not a stock currently overbought or oversold. This indicator is crucial in determining whether traders are tipped toward the side of buying more of the stock, or doing the opposite and selling more of the stock. This is very important directional information necessary for making trading decisions. (CGIX)s current measure for its 14-day RSI is 85.26%; this is suggestive that on balance of the indicator, the stock is currently overbought and may have reached the upper limits of upward movement, perhaps acting as a potential trigger for a price reversal. The stochastic picture presents a complimentary view of overall sentiment in the present state for (CGIX). Stochastic data gathered over the last 30 days has created a score of 91.02%. This indicates that the stock is overbought at current levels.

The successful trader has within her or her arsenal a wide range of tools. The leading indicators mentioned above help make up that arsenal but they are by no means the only ones needed for trading success. Short term indicators, as well as performance indicators, can mean all the difference in executing successful trades. The omens depict a telling picture in terms of the near-term trading setup for (CGIX); this makes things very interesting to the curious and interested eye. The +2.65 has created a positive in the trailing 30 days since initiating movement. Over the extended term, the stock has outperform the S&P 500 by 67.49%. This consistent movement and its attendant overall performance have produced higher daily volatility when compared with other stocks ranking in the same peer group and on the same exchange. The picture looks the same when the stock is assessed against volatility levels measured historically. This historical volatility gives a current reading of 149.35%. These measures of historic volatility are very handy in judging the underlying price momentum and the rate of change in the price of (CGIX). Bound up this picture of volatility, is another measure that gives the underlying thesis for (CGIX). This can best be seen by analyzing the readings for the stocks average true range, currently 13.03. ATR is a fine augment to the other indicators outlined above and should be used in conjunction and not as a standalone.

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Cancer Genetics, Inc. (CGIX) Has Revealed It All In Its Chart - NY Stock News

NEW YORK (GenomeWeb) Veritas Genetics announced today that it has agreed to provide BRCA testing for men and women who participate in a new initiative called The Screen Project being conducted at Toronto's Women's College Hospital (WCH).

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Veritas Genetics to Provide BRCA Testing to Participants in Canadian Breast Cancer Screening Effort - GenomeWeb