Category Archives: Human Behavior

The Shopping Cart Theory – Columbia Star

If youre on top of the Interweb universe like me, you probably already know The Shopping Cart Theory is the latest thing to mindlessly discuss. Ive been interested in shopping carts for yearsbuggies to Southernersbut didnt know the things were a barometer to a persons possible conduct.

The Shopping Cart Theory states whether a person places their cart back into the rack rather than leaving it wherever they please determines the goodness of that person. Not sure Im buying what theyre selling, but thats what the theory claims.

Sylvan Goldman invented carts in 1937 to get groceries from the store to the vehicle to help the customers save energy and also surreptitiously encourage them to buy more. Carts seem like a great service. All the customer needs to do is place the cart in the handy rack near their parking spot when finished.

The Theory claims that since there is no punishment for leaving the cart next to ones auto, the only pressure is societal norm. People who are innately good will return the cart to its resting place, and those who arent wont.

My first discovery of anything involving buggies was noticing when anyone left his or her cart in an unacceptable place someone else would soon leave a second cart next to it. A subtle permission slip since the second guy only copied another persons dubious action.

For those folks, like this one, who were raised by a mother who would immediately retort, If Tommy jumped off a cliff, would you? that implied permission is null and void. But I find this part of the Shopping Cart Theory to be more indicative of human behavior than the simple good vs. bad analogy.

Very little about human behavior is simple. We are influenced by all kinds of conflicting signals, most of which we havent even discovered yet. Our brain rewards us for actions that promote our survival and punish us for things that threaten it. We have all types of societal norms based on myths from centuries ago and more modern theories based on unreliable internet postings.

Most people refusing to return carts to racks may simply be lazy. They then complicate things by justifying their choice with excuses. I didnt see a cart caddie nearby. I was too tired to return it. I was saving someones job. Food is too expensive for me to do their work. When you want to justify something questionable any excuse will do.

I think many of us want determining the goodness of people to be simple. We like to think that societal norms and upbringing can determine the internal quality of a person. Many religions claim to be the originator of morality, yet there were people coexisting peacefully with each other for hundreds of thousands of years before the first religion was ever established.

I consider myself a good judge of character, yet Ive been surprised many times by people doing the opposite of what I thought they might do. The truth is we have no idea how to determine a persons goodness.

Maybe its time to stop judging people. You know, like the Good Book says.

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The Shopping Cart Theory - Columbia Star

Many countries have given us a preview of what’s to come with COVID subvariant BA.5. Prepare. – The Boston Globe

Though we have faced waves of several different variants since the original strain was first detected in Wuhan, BA.5 is a new beast with a host of challenges that we have not seen before. Not only does BA.5 have critical mutations in its spike protein, it also has numerous non-spike mutations in other areas of the protein, allowing it to largely evade immunity from prior infection (even recent infections), prior vaccination (even with boosters), and hybrid immunity a combination of vaccination and infection that was believed to denote a higher degree of protection, but is unable to prevent reinfection from BA.5. COVID-19 vaccination is still expected to provide substantial protection against severe disease leading to hospitalization and death. However, it is far less effective at preventing infection and transmission now than it once was, and every infection and reinfection is accompanied by the risk of long COVID.

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Our fate over the next few months will be defined by not only the behavior of BA.5 and emerging subvariants, but by human behavior. For the most part, mandates have disappeared in the United States and are unlikely to return. With the prevalence of pandemic fatigue, it is also doubtful that universal masking will return, no matter how large the surge.

Over the next few months, either BA.5 will infect so many people that it will burn itself out, or it will be replaced by a variant that is even better at infecting people. High-quality masks (N95/KN95), proper ventilation, physical distancing, and air filtration would help, but it seems unlikely that leadership at the local, state, or federal level will act on the coming BA.5 COVID-19 wave unless hospitals again become overwhelmed. Boosters would also help, but only about 1 in 4 of those 65 and older who received the first booster have received the second. A second booster will not protect fully against reinfection, but it significantly reduces the risk of dying from COVID-19 especially for those over the age of 50. People who can get a second booster, absolutely should.

The ever-changing nature of the pandemic means that there is a constant flow of new information, as well as endless opportunities for misinformation to spread from the distortion of facts on vaccine safety and effectiveness to ignorance about long COVID and misconceptions about new variants. I am a part of Team Halo, a global team of scientists and vaccine experts working with the United Nations to combat COVID-19 vaccine misinformation. As we learn about new variants and gather additional details about vaccine effectiveness, I use social media platforms like TikTok (@dr_asherwilliams) to bring updated information to the public and educate and engage those who get their news mostly through social media. When people choose not to get vaccinated or disregard public health measures based on inaccurate information, they put the health of many at risk leading to premature and preventable deaths in some cases. The fight to educate the general population is an often overlooked but vital component of public health.

On the horizon, we have Modernas Omicron bivalent booster vaccine candidate with promising data recently released showing higher efficacy against all variants of concern, including BA.5, compared to current boosters. Keep in mind that it took more than seven months for the bivalent Omicron booster to be tested. Meanwhile, this virus continues to outrun us. The time between new variant waves is becoming shorter as new versions of the virus continue to accelerate, and our rollout of adapted vaccines, clinical trials, and the Food and Drug Administration authorization timeline is racing to keep up with this furious pace. More focus should be placed on developing universal vaccines that are variant-proof and can protect against a wide range of coronaviruses.

Additionally, there needs to be further exploration of nasal vaccines, which harness the protective benefits of mucosal immunity and can deliver vaccines directly to the site where the virus first makes contact. In the meantime, it is up to each of us to determine our own risk tolerance, individually and as families, and use this to govern our behavior. If youve already had COVID, this is no excuse to throw caution to the wind as there is now evidence that long COVID risk increases with each reinfection.

Regardless of COVID-19 history and vaccination status, everyone will need and benefit from reinfection prevention strategies like universal masking while vaccine-makers are working on updated shots. Unfortunately, variants have changed the game for us and BA.5 is yet another COVID challenge to be dealt with.

Asher Williams is a postdoctoral fellow at Cornell University and incoming professor of chemical engineering at Columbia University.

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Many countries have given us a preview of what's to come with COVID subvariant BA.5. Prepare. - The Boston Globe

On The Dogma of The Self-Contained Voicebot – – Opus Research

In a previous essay, I proposed that Voice User Interface (VUI) design, as currently practiced, has been informed by two dogmas. The first is the dogma of emulation: The belief that VUI designers should aim to build voicebots that emulate how a human being interacts with another human being. For instance, the voicebots text-to-speech should sound as human as possible, its prosody should be crafted to convey the right emotion at the right time, that it should open interactions with human beings with pleasant greetings, that it should speak naturally and conversationally, and so forth. I argued that this dogma not only sets up the designer for failure by inflating the human users expectations only to deflate them as soon as the voicebot makes an error that a human being would not make (for instance, not understand something that the human said and that the human believes the voicebot should have easily understood), but also because it needlessly limits the ability of the designer to innovate: to use non-human sounds, to establish new protocols, to use new patterns and strategies, all focused on one thing: delivering the most effective voice interface that will enable the human user to get the job of solving their problem done using the voicebot.

In this essay, I propose to highlight a second dogma that I believe is inhibiting effective voicebot design: what I call The Dogma of The Self-Contained Voicebot. This is the dogma that holds that thanks to the expert work of the VUI designer, deploying the full power of their talent, skills and knowledge, the aim of the designer should be to deliver voicebots that will enable any human user, coming in cold to the voicebot, not even knowing what the voicebot does or why it was created, to use that voicebot effectively. According to this dogma, the designer should build a robust voicebot that can take a user who comes to the voicebot potentially almost as a blank slate and guide them to successfully to use the voicebot. This dogma holds that it is in fact the responsibility of the VUI designer to ensure that any human user is able to learn what the voicebot does in real time, on the fly, on the go, as it interacts with that human user in the heat of the exchange.

An example of a rule that flows directly from this dogma is the following: Never open a voicebot conversation by simply asking the user: How may I help you? Instead, the best practice proposed advises us to give the human user first a general sense of what the voicebot is about and then to provide them with a list of options that the human can select from. For instance: Welcome to Dominion One. I am here to help you with your banking needs. Which of the following do you want me to help you with: Check your balance, transfer money, or something else?

The Simplicity of Voicebot Menus Enable Swift, Accurate Conversations

Before I elaborate on why I believe that this dogma is not only unnecessary but that it undermines the very goal that it is earnestly trying to deliver on (the goal of usability), let me point out two things. First, I am not a detractor of clear and simple voicebot menus. On the contrary, I am a fan of simplicity, and voicebot menus are a powerful instrument that, if and when crafted carefully and with care, can help the human user move swiftly through a voicebot conversation. Moreover, I am attracted to the simple menu device because menus are not how human beings talk to other human beings, which, for me, is a refreshing violation of the first dogma the dogma of human emulation.

Which brings me to my second point: Although I caution against the dogma of emulation, I do not hold the flip dogma of never emulating human behavior under any circumstances. If there is a dogma or a principle that I follow, it is the one that cautions against all dogmas any and all rigid rules that will trap us and force us to act against our ultimate goal of delivering effective voicebots given the situation that we are designing for.

And so, against the often cited best practice of Never open your voicebot conversation by simply asking the user: How may I help you? I propose the following best practice: Whenever possible, open your voicebot conversation by simply asking the user: How may I help you?

Why would I say such a heretic thing? Isnt this how human beings open their conversations after they announce themselves? And if so, does this emulation not fly in the face of the first dogma that I am denouncing?

The answer is twofold: First, in my countering the dogma of emulation, I am, again, not condemning instances where the designer emulates the behavior of a human being, but rather the dogma itself which strives to always emulate a human being, or, emulate the human being whenever one can. In contrast, I propose that the designer should, whenever they feel it is appropriate, lean on the human-to-human model, but do so not as a matter of principle or dogma but opportunistically, when the emulation will lead to a felicitous interaction.

Why Voicebots Should Engage with Open-Ended Questions

But more importantly, I propose the best practice of having the voicebot open by asking the open question: How may I help you? for the following reason: For a voicebot that starts with that bold open question to succeed, the human users that come to the voicebot must come to it with a set of wants and goals that the voicebot is ready to understand and deliver on. And for that to happen that is, for the voicebot to systematically encounter only humans who come to it with the expected limited set of questions that the voicebot has been built to handle successfully two sets of crucial activities that are not within the VUI designers bailiwick must take place: (1) Voice UX research on who the user of the voicebot will be and what problems those users wish to solve, and (2) Post-launch socialization of the voicebot to ensure that those for whom the voicebot was built are aware of its existence, what its purpose is, and what they should expect it to help them with.

In other words, the mark of a great voicebot that will deliver value to as many humans who can benefit from that value as possible is a voicebot that can boldly open its engagement with the human being by asking the open question: How may I help you?&n; A voicebot cannot afford to ask that question is a voicebot that is usually failing on one or both of the following fronts: (1) The voicebot is engaging with people who are coming in with the expected closed set of questions and problems to solve, but the voicebot is not able to understand what the users are saying or fails to successfully help the human users solve their problems. Or, (2) The voicebot is engaging with people who are coming in with questions and problems that the voicebot was not designed to field in the first place. Only the first of these two is the fault of the designer. The second problem the one that accounts for the vast majority of voicebot failures and that leads VUI designers to avoid the open question conversation opening is not the fault of the designer but rather that of the voicebots Product Manager, the one who is supposed to ensure that: (1) Solid UX research is conducted so that we know what the people who are being targeted will ask for, (2) That such solid research is taken seriously by the Product Manager who will write up the functional requirements and the VUI designer who will design the voicebot, and (3) That the voicebot is marketed and surfaced to the users for whom the voicebot was designed and built in the first place.

In a nutshell, I propose a rejection of the dogma of the Self-Contained Voicebot that puts the burden of delivering a usable and robust voicebot almost wholly on the shoulders of the VUI designer because I believe that the only way to deliver a great voicebot is by elevating the (almost always) neglected activities and findings of both UX Research and Post-launch Marketing. Build a voicebot that can consistently handle, How can I help you? and you know that you have pinned down exactly who your target users are and what problems they want to solve, that you have designed your voicebot well, and that you have messaged the voicebots existence, how to engage with it, and what it was built to do for them, to exactly those who will benefit the most by giving a chance to the voicebot to help them help themselves.

Dr. Ahmed Bouzid, is CEO of Witlingo, a McLean, Virginia, based startup that builds products and solutions that enable brands to engage with their clients and prospects using voice, audio, and conversational AI. Prior to Witlingo, Dr. Bouzid was Head of Alexas Smart Home Product at Amazon and VP of Product and Innovation at Angel.com. Dr. Bouzid holds 12 patents in the Speech Recognition and Natural Language Processing field and was recognized as a Speech Luminary by Speech Technology Magazine and as one of the Top 11 Speech Technologists by Voicebot.ai. He is also an Open Voice Network Ambassador, heading their Social Audio initiative, and author at Opus Research. Some of his articles and media appearances can be found here and here. His new book, The Elements of Voice First Style (OReilly Media, 2022), co-authored with Dr. Weiye Ma, can be found here.

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On The Dogma of The Self-Contained Voicebot - - Opus Research

‘The Black Phone’ Ending, Explained: Does Finney Come Back? Is The Grabber Dead Or Alive? | DMT – DMT

The Black Phone, the 2021 horror/thriller, is directed by Scott Derrickson and based on a short story by Joe Hill. Derrickson says that he took instances from his life, molded them, filtered them, and made this short story into a full-fledged feature film. There is an uncanny resemblance between the writing of Joe Hill and his father, Stephan King. In a lot of Stephan Kings stories, you often saw flawed human behavior, you saw abuse, you saw innocence and the lack of it, and most importantly, you were left with a bittersweet nostalgia that took you back to your old days.

Though The Black Phone is supposed to be a horror/thriller, it is more about the developments that take place within than the ones taking place in the outer world. Derrickson grew up in Denver, Colorado, and he witnessed abuse and violence everywhere. Most of the children he knew had to face a lot of bullying. Those who were spared from it somehow, had to face the wrath of an abusive parent back home. It is important to warn everybody that before watching The Black Phone, you should be aware that horror and suspense are subordinate elements in this film. The film is about standing for another, always having the back of your loved ones no matter what, and about a different kind of maturity that doesnt wait for age to increase but takes its full shape and form through the experiences one has in life.

Spoilers Ahead

It was 1978, and a baseball match was taking place. Finney Blake had managed to get two strikes when Bruce Yamada hit him for a home run. Bruce was kind enough to come to Finney after the match and tell him that he had almost got him. Finney wasnt used to that kindness. He had always been bullied by his peers and had gotten used to that behavior somewhat. Things were not great at home either. His father was an alcoholic who often beat him and his sister, Gwen. Somewhere, his father wasnt able to deal with the loss of his wife. Though The Black Phone does not reveal anything about his past, you do make the speculation that things would have gone haywire after his wife departed. She used to see things that werent real, and that drove her crazy. He often used to get angry at Gwen when she told him that she also saw dreams that sometimes turned real. He told Gwen that her dreams were just dreams and nothing else. Though Finney didnt have many friends, Robin was a colleague, who not only considered him his good friend but also respected the fact that Finney never resorted to violence. He saved him multiple times from bullies, but at the same time told him that one day he would have to stand for himself.

Children were disappearing from the neighborhood Finney stayed in, and not even the authorities had a clue about what was happening. One day after the disappearance of Bruce Yamada, Gwen was called by her principal as Detective Wright, and Detective Miller had come to ask her some questions. They were on the lookout for a guy suspected to be behind these kidnappings, whom the people had nicknamed The Grabber. Gwen had told her friend, Amy Yamada, sister of Bruce, that she had seen in her dreams that Bruce was taken by a guy in a black van who happened to carry a lot of black balloons in it. The detectives had actually found two black balloons at the scene, and that piece of information wasnt revealed by them. The detectives suspected that Gwen knew something more, as it was not believable whatever she was telling them.

The next morning, Gwens dad whipped her mercilessly. He was beating her as the police had come to the office and asked about Gwen. Finney stood there in horror and saw his beloved sister being beaten by his father. He was petrified, yet there was a fire raging inside him. He wanted to go ahead and stop his father, but he didnt have the courage. The next day, Robin Arellano went missing, and Finney was distraught, as he was his friend. On Fridays, Gwen used to do a sleepover at her friends and Finney, while departing, always used to tell her to have fun, and that he would take care of their father. But that day he didnt reach home to look after his father. He was taken by the Grabber. A shattered Gwen, after hearing the news of her brothers disappearance, runs back to her home and starts praying to her God, hoping that some miracle would happen and he would come back safely.

Finney was taken to a basement by the Grabber. There was just a mattress and a landline phone, with its wire cutoff. The Grabber suddenly heard a phone ringing somewhere and told Finney that he would come back with a soda for him after he attended the call. The phone in the basement started ringing too, and Finney didnt understand how it was happening. The Grabber had told him that the phone hadnt worked since his childhood. But that was not true. The Grabber was in denial. He, too, heard the phone ringing; he just didnt want to accept it. Finney heard the phone ringing a couple of times more, but nobody spoke from the other end. The basement was soundproof, and Finney had a feeling that he wouldnt be able to escape from there ever. But then something inexplicable happened. A boy spoke from the other end. He didnt remember his name, but Finney recognized him. It was Bruce Yamada. He told Finney that it rang when he and the other kids were there too, but none of them could hear anything. He tells him that there was a dirt section on the other side of the hallway, beneath the floor itself. He asked him to dig it up. Finney started digging as much as he could. He covered the section with a carpet and flushed the dirt that he took out into the pot.

The next time the Grabber came, he brought some breakfast. But surprisingly, when he went, he left the door open. Finney saw that and was about to escape when the phone rang again. This time it was Billy Showalter, who also couldnt remember his name. Finney recognized him as he said that he used to deliver newspapers. Billy told him to not go out of the room as it was a trap. The Grabber was waiting upstairs for him to escape. Billy says that in all probability he would be caught by the Grabber who would then start beating him with a belt. Billy told him on the next call that there was a cable that was under one of the walls that he had torn loose during his stay in the basement. Finney finds that cable, and tries to escape from the window using it. But even after multiple attempts, he is unable to do it. The next call he got was from Griffin Staggs, who told him that just because he was not taking the bait of the Grabber, it was making him restless. The Grabber used to call this game Naughty Boy, and he had kept the door unlatched for a reason. He would win the game by beating the kids who tried to escape and then move on to the next level. Finney was not escaping, and Billy says that he would have to let Grabber beat him once, to buy some more time before he kills him. Billy also told him that on his door, he had put a lock that he used for his bike. He had carved out the lock combination on the walls and asked Finney to check for it. Finney gets it and goes upstairs. He escapes, but The Grabber catches him just in time and brings him back.

The next call was from Vance Hopper, a person from whom Finney was once very scared. Vance was an outlaw who was known for his rugged behavior. He told Finney that there was an outlet through which he could get into the storeroom on the other side, via a freezer. Finney tries that too, but to no avail. He is scared, frustrated, and slowly losing hope that he will ever be able to escape. The last call he gets is from Robin, his friend. Finney came to know that each and every child he had talked to, was already dead. The phone acted as a portal that connected the people in this realm to those who had departed. The boys had done their best but were not able to escape. Robin tells Finney that he had to escape, if not for himself, then for all those people who had met their fateful end in that very basement. He tells him to fill the telephone receiver with dirt and practice a hook, which he could use on the Grabber when the time comes.

Meanwhile, Gwen had gotten a dream where she had seen a house with a number, 7741. She knew that something was happening there. She informs the authorities about the same. Finney was waiting for The Grabber to come, but his brother, Max, showed up instead. Max was a cocaine addict and a conspiracy theorist. The police had once come to the house, but after listening to all his theories, they thought of him as just another addict who had lost his mind and was talking nonsense. The Grabber came from behind holding an ax and killed his own brother. He came after Finney, who ran to the other side of the room. He came chasing him, but tripped on a wire and fell inside the hole that Finney had dug in the floor. Finney had created a trap using all the things that he had found through the callers. Next, he hits The Grabber with the phone receiver and snaps his neck using the phone wire. Once again, the phone rings, but this time Finney knew it was not for him. The dead kids had called to curse The Grabber and tell him that they had finally gotten their revenge. Finney used the meatloaves he had got from the freezer to distract The Grabbers dog. He came out of the house and found his sister sitting on the other side of the road, surrounded by police vans. The police came to know that there were two houses; in one, The Grabber used to torment the children, and in the other, he used to bury their dead bodies. Gwen reunited with her brother and gave him a warm and tight hug. Finally, Finneys nightmare came to an end, and with it, the case of the Grabber was also solved, which gave respite to each and every resident of North Denver.

The Black Phone is a 2022 Drama Thriller film directed by Scott Derrickson.

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'The Black Phone' Ending, Explained: Does Finney Come Back? Is The Grabber Dead Or Alive? | DMT - DMT

Inflammation May Link Sleep Disturbances and Alzheimer’s – Technology Networks

A multisite research team from the University of California, Irvine, the University of WisconsinMadison and Wake Forest University has discovered that brain inflammation may link Alzheimers disease risk with sleep disturbance, which may aid early detection and prevention efforts by identifying novel treatment targets at preclinical stages.

Brain inflammation, sleep disturbance and disrupted brain waves have all been associated with Alzheimers disease, but the interactions among them have not been investigated until now. The study, published online today in the journalSleep, examined whether inflammation had any effect on specific brain waves called fast sleep spindles, which have been shown to promote long-term memory retention.

Our findings indicate that age-related increases in brain inflammation have a downstream effect on Alzheimers disease-related tau proteins and neuronal synaptic integrity. This results in deficits in the brains capacity to generate fast sleep spindles, which contribute to age-related memory impairment in older adults. Discovering these mechanisms is an important step in identifying at-risk individuals as early as possible and developing targeted interventions, said Bryce Mander, Ph.D., UCI assistant professor of psychiatry & human behavior and the studys lead and co-corresponding author.

Chronic activation of the brains immune cells, called glial cells, increases with age, elevating production of beta-amyloid and tau proteins, the hallmarks of Alzheimers disease. Independently, sleep disturbance has been linked to Alzheimers disease pathology in the brain, and studies have also indicated an association between sleep disturbance and inflammation. Selectively disrupted fast sleep spindles have been identified in normal aging as well as preclinical stages of Alzheimers disease, but it has not been clear what causes this and what it means for memory impairment in older at-risk adults.

For the study, 58 cognitively unimpaired adults in their 50s and 60s were examined at the University of WisconsinMadison. All had a parental history of Alzheimers or a genetic risk factor for it, but none of them had beta-amyloid plaques or neurofibrillary tau tangles. Sleep was recorded overnight using high-density electroencephalography to map brain wave expression during sleep, and overnight memory retention was assessed. Participants also underwent a lumbar puncture so that cerebrospinal fluid biomarkers of central nervous system inflammation, beta-amyloid and tau proteins, and neuronal integrity could be examined.

Statistical tests were used to evaluate whether the effect of age on fast sleep spindles was mediated by Alzheimers-related proteins. Researchers found that activation of two types of glial cells microglia and astrocytes, which trigger brain inflammation was associated with disrupted expression of fast sleep spindles. The fact that these relationships were identified in people without any accumulation of beta-amyloid plaques or neurofibrillary tangles indicates that sleep deficits and inflammation might be among the earliest warning signs of Alzheimers disease.

We dont yet know whether anyone in this study will develop Alzheimers disease dementia, but one of the reasons that our studies enroll participants in midlife is so that we can potentially detect problems before people develop disease symptoms, said co-author Barbara Bendlin, Ph.D., professor of medicine at the University of WisconsinMadison.

These findings show that the effects of brain inflammation on sleep spindles and memory occur through its effects on neuronal activity and Alzheimers disease-related proteins and are apparent even before pathological positivity, said Dr. Ruth Benca, the studys senior and co-corresponding author and Wake Forest professor and chair of psychiatry and behavioral medicine. This offers a promising therapeutic target to stop cognitive decline associated with aging and Alzheimers.

Reference:Mander BA, Dave A, Lui KK, et al. Inflammation, tau pathology, and synaptic integrity associated with sleep spindles and memory prior to -amyloid positivity. Sleep. 2022:zsac135. doi:10.1093/sleep/zsac135

This article has been republished from the following materials. Note: material may have been edited for length and content. For further information, please contact the cited source.

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Inflammation May Link Sleep Disturbances and Alzheimer's - Technology Networks

Pocket Gophers May Be the First Non-Human Mammal to ‘Farm’ – Smithsonian Magazine

The gophers spend most of their time underground and only venture to the outside world to forage for food or mate. Veronica Selden/UF

Beneath North and Central American grasslands, pocket gophers dig labyrinths of winding tunnels hundreds of feet long. Now, researchers have found that the rodent architects may also be farmers, tendingto underground roots they harvest for food.

As the gophers construct their large tunnels, they turn over the soil, aerating it in the process, and munch on roots that grow and hang in the tunnels over time, reports Evrim Yazgin forCosmos. The behavior is not advanced agriculture, but it is a carefully managed food production system that provides the optimal conditions for root growth, Oliver Whang reports for theNew York Times. This week, details on the mammals root cropping behaviors were published inCurrent Biology.

Pocket gophers are brown rodents about the size of a Guinea pig. Their dietconsists of roots, stems,and some weeds and grasses above ground, reportsSciencesKatherine Irving. The gophers spend most of their time underground and only venture to the outside world to forage for food or mate.

To find out how and why the gophers construct large tunnels on their plant-based diets, scientists at the University of Floridadug trenches around three gopher tunnel sections in a Gainesville pastureand placed oil barrels at each trench to keep them out,Sciencereports. From here, the team photographed the blocked sections and noticed thatroots grew and filled the areas, whereas, in the places left open for the gophers to roam, the roots stayed short.

The researchersthen calculated the daily root growth to determinehow much of the gophers energy needs could be met by harvesting the roots, astatementexplains. Previously, it was thought that the gopherssurvived by eating away at roots they encountered while constructing their tunnels. Based on the calculations, the scientists found that the energy needed to dig a tunnel is too much to be supported by the roots that gophers eat while excavating it, but if they eat roots grown in other tunnels that are already dug, they can meet the energy expenditure, reports Sofia Quaglia forNational Geographic.

Through building and maintaining the extended networks of tunnels, the gophers create an environment for roots to thrive. The animals also scatter their poop and urine within the tunnels, which fertilize the growing roots, perNational Geographic. Theyre providing this perfect environment for roots to grow and fertilizing them with their waste, says Veronica Selden, a zoologistat the University of Florida and the studys first author, in a statement. When the potato-sized mammals nibble on the dangling roots, they also encourage growth.

Youre a small mammal going along, and you encounter a large root, and you bite it off, but its not very digestible because it has a lot of lignin or celluloses, its tough, its hard, says Francis Putz, an ecologist and study author at the University of Florida, toNational Geographic. But in response to being cropped, that root will make many small roots, and those will be really tasty and more digestible. By harvesting the root crops, the gophers can supply 21 to 62 percent of their energyneeds, making up the rest of the calories needed to continue their burrowing habits.

While some expertsargue that the gophers aren'ttechnically farming because they dont plant, weed or distribute their crops, the researchers involved in thisnew study think the finding opens upthepossibilitythat other ground-dwelling rodents could have behaviors that qualify as husbandry too.

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Pocket Gophers May Be the First Non-Human Mammal to 'Farm' - Smithsonian Magazine

Precision health perspectives – UCI News

In February, UCI launched the Institute for Precision Health, a campus-wide, interdisciplinary endeavor that merges UCIs powerhouse health sciences, engineering, machine learning, artificial intelligence, clinical genomics and data science capabilities. The objective is to identify, create and deliver the most effective health and wellness strategy for each individual person and, in doing so, confront the linked challenges of health equity and the high cost of care.

IPH will bring a multifaceted, integrated approach to what many call the next great advancement in healthcare. The institute is an ecosystem for collaboration across disciplines that comprises seven areas. Along with co-directing the institute, Leslie Thompson Donald Bren and Chancellors Professor in psychiatry & human behavior and neurobiology & behavior co-leads the precision omics section, which generates and translatesgenomic, proteomic and metabolomic research results into clinical applications.

Thompson is among the earliest trailblazers in pursuing personalized treatment strategies for neurodegenerative diseases. Under her co-direction, IPH pushes for understanding the mechanisms for neurodegenerative and other diseases for which there are currently no treatments available. A long-time Anteater, Thompson earned her masters and Ph.D. from UCI.

Why is the Institute for Precision Health so important to you?

So far, precision medicine approaches have mostly commonly been used to treat cancer. Clinicians can utilize data-driven approaches to determine whether a given drug would be expected to work in a specific individual. Ive dedicated my career to studying neurodegenerative diseases like Huntingtons and ALS. With so many of these diseases, including the more common Alzheimers and Parkinsons disease, there is no treatment available that changes the course of the disease, and so many clinical trials have failed to show benefit to patients. Many researchers think the reason there is so little by way of treatment is because we havent been able to fully understand the diseases in individuals that there is not a one-size-fits-all in disease treatment. We need to have ways of understanding diseases in subgroups of patients that incorporates their genetics, environment and other factors that influence health so that we can define diseases better, understand them better and hopefully treat them better. Thats one aspect of IPH that really motivates me.

The capabilities of Institute for Precision Health might allow for better treatments?

Yes. And more. With the resources of IPH, what we can do has broadened significantly. So not only can we use data to understand these diseases and subgroups of patients better, but we can also develop and use state-of-the art analytic tools such as machine learning and artificial intelligence to distinguish individual disease features and or predict the course of disease. The capabilities of IPH through efforts of clinicians who use AI have enabled establishing a scoring system to inform which COVID-19 patients would be predicted to lead to more severe disease and thus greater medical intervention and optimized patient treatment. A critical aspect of healthcare is to understand the needs of the community as well, which is a major component of IPH. A goal is to utilize the infrastructure being developed through IPH to help clinical trials happen much more rapidly with the right cohort of patients, have new ways to evaluate effectiveness of treatments, engage communities and move into a realm of greater partnership with patients and their communities.

The capacity of UCIs Collaboratory the data center of IPH is key?

Yes. It is extremely challenging to put the various forms of data and information for, say, a given person or a given disease together in one place one platform so that researchers, clinicians and other partners can access and work with the data. With UCIs Collaboratory and our platform provider Syntropy, we can gather not only the de-identified health information that is in the medical record but also relevant genomic or other clinical or research data. The goal is to provide broad benefit to UCI and broad engagement across campus. And really beyond the campus.

Does this feel a little like the launch of the first smart phone, where in the beginning we marveled at the cool features and then, almost immediately, we couldnt imagine life without it?

I think so. And, you know, we had so many of the components here at UCI that have been brought together AI tools being developed across campus and the ability to carry out genomics and other omics, and then the efforts of the Collaboratory and the platforms that can house data. But while components were there, they hadnt yet been integrated into that smart phone, so to speak. Now were putting the components together and continually improving capabilities. Our vision is to provide a systematic approach to accomplish things we have never been able to do previously. Even seemingly small things like, how do you track one patient without any identifiers and all the information thats relevant to that patient and their disease? And so much more.

Youve been a part of groundbreaking research and have had so many professional accomplishments. How exciting is IPH in comparison to what youve already done?

Ive been involved in many very meaningful research projects in my career, but to be perfectly honest, this is huge for me, as I feel it ultimately can help the families that I so passionately care about. I see this as my whole career in human genetics and studying human disease has led up to IPH.

The vision is right, the opportunity is here, and UCIs leadership is so supportive of IPH. There is a growing excitement that, yes, we can do something transformative. So, I hope for big things to come out of IPH. Yes, Im all in.

You mentioned that you believe the work IPH does will benefit people beyond the campus. Can you talk a little bit about that?

I think well see further relationships with industry, with community groups, with other research institutions and clinical entities and most importantly with the patients themselves. We are building something that increases our ability to use and integrate data, and that will be useful to so many people and will enable greater health equity.

Do you have any sort of success timeline in mind?

I think most researchers hesitate to think that way because there have been diseases many of us thought wed have a cure for in 10 years, and 30 years later there isnt even an effective treatment. But, that said, I do think that the great thing with this is that many of the components have already been initiated and are working and we have incredible opportunities to now integrate efforts and diverse sets of data to inform patient health and disease. Im confident that there will be immediate goals that IPH will achieve throughout the next year or two. Then there are longer goals that will take five years or 10 years. And even longer-range goals that will be refined as we go.

Do you believe that even in a year or two patients who get care through UCI will feel the effects of IPH?

Yes, absolutely. Patients are already impacted because of IPHs work with COVID-19. One project involving genomics is to try and pinpoint the diagnosis for patients with a muscle weakness disorder that has defied genetic diagnosis. During this next year, well see if we can find genetic causes of that disorder. And through efforts of the AI groups, there will be development of algorithms to assess effectiveness of tools or treatments recently deployed in the hospital. Those are just a couple examples.

Do you see a day where many diseases are diagnosed quicker and more accurately?

Thats certainly one of our goals. IPH researchers have already developed an AI tool to diagnose stroke much more quickly compared to more standard methods. I suspect IPH will be working on many more tools that function in similar ways.

What does UCI bring to the table that maybe some other institutions dont?

One big strength is the support from Chancellor Howard Gillman and other campus leaders. [Vice Chancellor of Health Affairs] Steve Goldstein has led the charge for this institute to become a reality. Also, the fact that we have so much AI, machine learning and artificial intelligence expertise across UCI along with many acclaimed clinicians and medical researchers. Having an academic medical center certainly presents opportunities that researchers elsewhere might not have where they may have great AI expertise but without a medical center. We also perhaps have a unique focus health equity with existing relationships with the community. So, we are distinctive in the fact that we have all the pieces here. UCI is also a uniquely collaborative and nimble institution. We come together and make things happen quickly at UCI. Thats a characteristic of this university that Ive seen play out during my whole career here.

Will there be opportunities to study Orange County to see, as a community, what kind of impact IPH has?

IPH is engaged in this already, and it is a major goal moving forward.

And the way youre able to use data is special?

Yes. Quite often researchers have pulled information from the medical records that is structured data, that has an important role in research that has been facilitated at UCI through efforts of the Collaboratory. However, one of the things that is unusual about the platform is that there will be ways to capture all the structured and unstructured data. This is a big deal.

Everything needs funding, though. Whats happening in that regard?

Yes, great question. Certainly, one of the biggest challenges for any endeavor is raising money. Through support by UCI, we have the funds to launch IPH efforts, but there will need to be extensive fundraising and plenty of grant writing. Philanthropy will be integral to our success and visionaries to relay the excitement about our mission.

If you want to learn more about supporting this or other activities at UCI, please visit the Brilliant Future website athttps://brilliantfuture.uci.edu. Publicly launched on October 4, 2019, the Brilliant Future campaign aims to raise awareness and support for UCI. By engaging 75,000 alumni and garnering $2 billion in philanthropic investment, UCI seeks to reach new heights of excellence instudent success,health and wellness, research and more. UCI Health Affairs plays a vital role in the success of the campaign. Learn more by visitinghttps://brilliantfuture.uci.edu/uci-health-affairs/.

About UCI Institute for Precision Health: Founded in February 2022, the Institute for Precision Health (IPH) is a multifaceted, integrated ecosystem for collaboration that maximizes the collective knowledge of patient data sets and the power of computer algorithms, predictive modeling and AI. IPH marries UCIs powerhouse health sciences, engineering, machine learning, artificial intelligence, clinical genomics and data science capabilities to deliver the most effective health and wellness strategy for each individual person and, in doing so, confronts the linked challenges of health equity and the high cost of care. IPH is part of UCI Health Affairs, and is co-directed by Tom Andriola, vice chancellor for information, technology and data, and Leslie Thompson, Donald Bren Professor of psychiatry & human behavior and neurobiology & behavior. IPH is a comprised of seven areas: SMART(statistics, machine learning-artificial intelligence), A2IR(applied artificial intelligence research), A3(applied analytics and artificial intelligence), Precision Omics(fosters translation of genomic, proteomic, and metabolomic research findings into clinical applications), Collaboratory for Health & Wellness(providestheecosystem that fosters collaboration across disciplines through the integration of health-related data sources), Deployable Equity(engagescommunity stakeholders and health-equitygroupsto create solutionsthat narrow the disparities gap in the health and wellbeing of underserved and at-risk populations.) and Education and Training (brings data-centric education to students and healthcare practitioners so they can practice at the top of their licenses).

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Desperate Characters and the Chaos That Lies Beneath – The New York Times

This essay is part of Ts Book Club, a series of articles and events dedicated to classic works of American literature. Click here to R.S.V.P. to a virtual conversation about Desperate Characters, to be led by Sigrid Nunez and held on Aug. 4.

IN THE WINTER of 1991, I was a resident for a month at Yaddo, the artists retreat in Saratoga Springs, N.Y. On the second floor of one of the buildings on the property was a small library, which was also where, at that time, artists in residence during the winter season took their meals. One day, I happened to see on a shelf a novel called Desperate Characters by Paula Fox. Though the title was new to me, the author was not. Some years earlier, I had read another book by Paula Fox, a childrens novel called One-Eyed Cat. Published in 1984, it had been assigned to me as part of my freelance work for an agency called Triad Artists, assessing books for possible movie deals. I loved the novel, a beautifully written story set in the mid-1930s in upstate New York, whose main character, 11-year-old Ned Wallis, is tormented by the fear that an air rifle shot he took at a shadow in the moonlight may have put out the eye of a feral cat. His guilt is compounded by the fact that his father, a Congregational Church minister, had forbidden him to use the rifle a birthday gift from Neds uncle until Ned is older. Now he lives in secret shame, unable to confess and trapped in a series of lies he tells to hide what has happened from his parents.

My enjoyment of One-Eyed Cat made me want to read Desperate Characters, Foxs second novel for adults, published in 1970, and one in which a cat also happens to play a significant role. In this case, though, it is the cat that causes the injury by literally biting the hand that feeds it the hand of a woman, the novels main character, Sophie Bentwood. This incident occurs right at the beginning of the book and, as we read on, we are kept in suspense as to how serious the bite is, whether the cat a stray might be rabid and why Sophie, an intelligent and educated woman, would rather deny the problem, even as her hand swells and throbs, than seek medical advice. Another source of suspense has to do with whether or not an extramarital affair she once had will come to light.

Sophie is a literary translator (though at the moment she finds herself unable to summon any enthusiasm for her work) and the wife of a lawyer named Otto. Middle-aged and childless, the Bentwoods live in an area of Brooklyn that, while gentrifying (the period is the late 1960s), remains surrounded by slum people. From their quiet, handsomely furnished townhouse, they can hear disturbing noises, such as the cries of a mistreated dog. They can see piles of garbage and even more sordid sights, including, once, a half-naked drunk sprawled in the street. The Bentwoods own a Mercedes-Benz and a second home on Long Island. When, hoping for a respite from urban disorder, they decide to drive there, they find that the house has been broken into and many of their possessions have been destroyed. So much for escape. Tellingly, it seems, nothing was stolen: the intruders only goal had been vandalism.

Although it received good reviews when it first appeared, Desperate Characters failed to sell. Foxs previous adult novel, Poor George (1967), had met a similar fate, and all together the six adult novels she published sold so modestly that, by 1992, every one of them had gone out of print. Fox continued to write childrens books, however (she would publish more than 20 in her lifetime), and, in addition to being a reliable source of income, that writing brought her several accolades, among them a 1974 Newbery Medal, and, in 1978, for her body of work, the highest international honor given for childrens literature: the Hans Christian Andersen Award.

One of my fellow residents at Yaddo in 1991 was the novelist Jonathan Franzen, who was finishing up work on his second book, Strong Motion (1992). When at breakfast one morning he mentioned that he was looking for something to read, I recommended Desperate Characters. As he would write in an essay published in Harpers in 1996, it produced an effect so profound in him that it felt like an instance of religious grace. A few years later, the writer and editor Tom Bissell, whod read Franzens essay and Foxs novel and who was working at the publishing house W. W. Norton, succeeded in getting Desperate Characters reissued. In an introduction to the new edition, which came out from Norton in 1999, Franzen pronounced the book not just inarguably great but obviously superior to any novel by Foxs contemporaries John Updike, Philip Roth and Saul Bellow. Another novelist, Thomas Mallon, called this claim almost more embarrassing than the neglect it sought to remedy, but added if this is what it took to give Foxs oeuvre a commercial pulse, one finds the zeal pardonable enough.

That commercial pulse quickened: Over the next few years Norton brought each of Foxs other adult novels back into print. And so, for the last 18 years of her life (she died, aged 93, in 2017), she had the satisfaction of seeing her long-overlooked work reach a wide and appreciative audience. In response to this turn of events she said, Im surprised, but Im not surprised. Its not that I thought so well of my books, its that in some way I think so well and highly of truth, and I know that my novels have a tiny bit of truth in them. Truth: Thats what I care about.

A not so tiny bit of truth that Fox is clearly after in Desperate Characters can be found in these famous words from Henry David Thoreaus book Walden (1854), which are alluded to in the novels penultimate chapter: The mass of men lead lives of quiet desperation. What is called resignation is confirmed desperation. On the surface, the Bentwoods might seem resigned to the fact that now and then unpleasant things may disrupt their privileged, well-ordered existence and sustained by the belief that they have the means not just their wealth and cultivated tastes but the right middle-class moral values to prevail. But over the course of one long weekend, we see what deep uncertainty and frustration roil just beneath.

Ticking away inside the carapace of ordinary life and its sketchy agreements was anarchy, Sophie at one point reflects. One of the sketchy agreements referred to here is marriage. Husband and wife frequently flare up at each other, but the trouble is always quickly smoothed over. They carry on, seeing themselves grow more and more estranged from each other yet helpless to stop it. For Fox, this kind of estrangement is a common aspect of domestic life, and how unknowable we remain to one another, even in our intimate relationships, is an inescapable part of the human condition.

THE BENTWOODS BEHAVIOR can sometimes strike us as irrational: For example, Sophies simultaneous dread and denial about the possibly serious consequences of the cat bite, and Ottos nearly unhinged response to the breakup of his longtime friendship and law partnership with a man named Charlie Russel. Charlie himself is as desperate as anyone. Unlike the archconservative Otto, who has nothing but contempt for the social and cultural movements of the 60s, Charlie yearns to be a part of them a woke lawyer defending the unlovely and unloved, in Ottos jeering phrase but he comes across as muddled, weak and histrionic. I care about everything, he tells Sophie, giggling. In my desperate fashion. Its desperation that keeps me going.

Though Foxs attitude toward her characters has an element of compassion, she does not spare them. She is a realist, well aware that people rarely escape having to live with the mistakes they have made. A poignant scene reveals Sophie forced to face the truth about her secret affair with Francis Early, a client of Ottos with whom the Bentwoods became friends, and who ended up rejecting her: Yet, for a bitter moment, she was caught up in the old tormenting question: What if Francis had been available? If the door had swung open, would she have gone through it? She glanced over at Otto. Francis had not only deprived her of himself. He had cheated her of her certainty about Otto.

Perhaps the strangest moment in Desperate Characters a work that abounds in strange moments, which is one of the things that makes it so compelling occurs near the end, when Sophie lashes out at an old friend with such gratuitous cruelty that the reader immediately thinks back to that horrid cat sinking teeth and claws into Sophies flesh unprovoked. Up till this point, we have seen Sophie as flawed but mostly sympathetic certainly never vicious and this glimpse into her dark depths is chilling. This scene is soon followed by the spectacle of Otto, in a final outburst of rage against Charlie, who has telephoned in desperate need of speaking with him, smashing a bottle of ink against the Bentwoods bedroom wall. Behold the couple, making their own nasty little contributions to the coarseness and destructiveness theyve been lamenting ever since we met them. Fox makes this bizarre and violent culmination feel entirely inevitable. In what is probably the novels most often cited line, Sophie thinks out loud: God, if I am rabid, I am equal to what is outside. And grim though it may be, the clarity of this epiphany, which comes in the midst of so much bewildering uncertainty, gives her an extraordinary relief. (As I said: strange.)

Discussing her approach to writing about people, Fox once said: I think its not helpful to overpsychologize. It substitutes for the chaos that most of us live in. And thats what Ive been writing about, that chaos. One of Desperate Characters most admired qualities is Foxs ability to write about that chaos in such unfailingly controlled, elegant and lucid prose.

In the era of Covid-19, it is especially unsettling to read a narrative driven by dread of a deadly infection. And what a shudder of recognition this image of Sophie brings: Whats going to happen? she burst out. Everything is going to hell Oh, dont we know all about it: the anarchy ticking away, threatening at any moment to be explosively loosed upon the world. Rabid strikes me as a good way to describe how what is outside can feel to us today: the race and class conflicts, the polarized rage, the fear that at any moment we or a loved one could be the victim of some violent act. The center not holding, the thin veneer of civilization and how little it takes to fall through how often, lately, do we come across these sentiments? Resonant, too, is the books sharp analysis of gentrification: the inequality and social segregation and displacement of the have-nots that are among its consequences, as well as the hapless flailing of the displacing haves over what position to take in regard to this harsh reality.

A root of Foxs obsessions with disorder and incomprehensible human behavior was revealed in 2001, when she published Borrowed Finery, a memoir distinguished both for its enthralling portrait of an unusually chaotic childhood and an utter absence of self-pity. An inconvenience to her selfish parents, Fox was dumped in a Manhattan foundling home right after her birth in 1923. Growing up, between occasional visits with her parents, which went very badly, she was handed off to various friends, relatives and sometimes strangers. But in one way, her parents brutal negligence was also a stroke of luck, for it brought Fox, from the age of 5 months to 6 years, into the care of a man named Elwood Corning. Like the good, loving father in One-Eyed Cat, for whom he was obviously a model, Corning was a Congregational minister who lived in a hamlet in upstate New York. He was so good to me, Fox recalled, and she loved him dearly. Among other kindnesses, Uncle Elwood taught her how to read, and I have no doubt that spending those critical early years under his wing and away from her hostile, unstable mother saved Fox from what the psychiatrist Leonard Shengold called soul murder: the common fate of people traumatized as children by abusive and neglectful parents.

Fox once spoke to an interviewer about the strength of life of the injured cat in One-Eyed Cat, which she called the heart of that book, and how much it meant to her. Her stories for young readers are often ones of resilience, showing lonely or uncared-for children struggling to make their way in a baffling and at times treacherous world. Many of these children are outsiders, and Fox always saw herself as someone with an outsiders point of view. She was also exceptionally resilient and persistent, continuing to write, which she first began doing as a child, despite much disappointment and rejection. It is this grit that wins my greatest admiration. Without it, Foxs strange, beautiful, truth-telling work would not exist.

Sigrid Nunez is the author of nine books, including The Friend, winner of the 2018 National Book Award for fiction, and, most recently, What Are You Going Through (2020).

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Desperate Characters and the Chaos That Lies Beneath - The New York Times

Tyranny of the majority: The spiraling overreach of the federal government – Washington Times

OPINION:

Which is better to be ruled by one tyrant three thousand miles away, or three thousand tyrants one mile away? Rev. Mather Byles (1706-1788)

Does it really matter if the instrument curtailing liberty is a monarch or a popularly elected legislature? This conundrum, along with the witty version of it put to a Boston crowd in 1775 by the little-known colonial-era preacher with the famous uncle Cotton Mather addresses the age-old question of whether liberty can long survive in a democracy.

Byles was a loyalist, who, along with about one-third of the American adult white male population in 1776, opposed the American Revolution and favored continued governance by Great Britain.

He didnt fight for the king or agitate against George Washingtons troops; he merely warned of the dangers of too much democracy.

No liberty-minded thinker I know of seriously argues today in favor of a hereditary monarchy, but many of us are fearful of an out-of-control democracy, which is what we have in America today. I say democracy because there remain in our federal structure a few safeguards against runaway federal tyranny, such as equal state representation in the Senate, the Electoral College, the state control of federal elections, and life-tenured federal judges and justices.

Of course, the Senate as originally crafted did not consist of popularly elected senators. Rather, they were appointed by state legislatures to represent the sovereign states as states, not the people in them. Part of James Madisons genius was the construction of the federal government as a three-sided table. The first side stood for the people the House of Representatives. The second side stood for the sovereign states that created the federal government the Senate. And the third side stood for the nation-state the presidency. The judiciary, whose prominent role today was unthinkable in 1789, was not part of this mix.

In his famous bank speech, Madison argued eloquently against legislation chartering a national bank because the authority to create a bank was not only not present in the Constitution but also was retained by the states and reserved to them by the 10th Amendment.

In that speech, he warned that the creeping expansion of the federal government would trample the powers of the states and also the unenumerated rights of the people that the Ninth Amendment his pride and joy because it protected natural rights prohibited the government from denying or disparaging.

He gave that speech in February of 1791, 11 months before the addition of the Bill of Rights the first 10 amendments to the Constitution. Given the popular fears of a new central government, Madison assumed that the Bill of Rights would be quickly ratified. He was right.

His bank speech remains just as relevant today.

Had Madison been alive during the presidency of the anti-Madisonian Woodrow Wilson who gave us World War I, the Federal Reserve, the administrative state and the federal income tax he would have recoiled at a president destroying the three-sided table. Wilson did that by leading the campaign to amend the Constitution so as to provide for the direct popular election of senators. Nor would Madison have stomached the efforts today by liberal Democrats to amend the Constitution to provide for the direct popular election of the president.

Part of Madisons genius was to craft anti-democratic elements into the Constitution. And some of them like retaining state sovereignty created laboratories of liberty. President Ronald Reagan reminded the American public in his first inaugural address that the states formed the federal government, not the other way around. Had I been the scrivener of that speech, Id have begged him to add: And the powers that the states gave to the feds, they can take back.

Reagan also famously said that we could vote with our feet. If you dont like the over-the-top regulations in Massachusetts, you can move to New Hampshire. If you are fed up with the highest state taxes in the union in New Jersey, you can move to Pennsylvania.

But the more state sovereignty the feds absorb the more state governance that is federalized the fewer differences there are among the regulatory and tax structures of the states. This has happened because Congress has become a general legislature without regard for the constitutional limits imposed on it.

If Congress wants to regulate an area of human behavior that is clearly beyond its constitutional competence, it bribes the states to do so with borrowed or Federal Reserve-created cash. Thus, it offered hundreds of millions of dollars to the states to lower their speed limits on highways and to lower the acceptable blood alcohol level in peoples veins this would truly have set Madison off before a presumption of DWI may be argued; all in return for cash to pave state-maintained highways.

The states are partly to blame for this. They take whatever cash Congress offers, and they accept the strings that come with it. And they, too, are tyrants. The states mandated the unconstitutional and crippling lockdowns of 2020-2021, not the feds. The states should be paying the political and financial consequences for their misdeeds, not the feds. They took property and liberty without paying for it as the Constitution requires them to do, not the feds.

Byles feared a government of 3,000. Today, the feds employ close to 3 million. Thomas Jefferson warned that when the federal treasury becomes a federal trough, and the people recognize it as such, they would only send to Washington politicians faithless to the Constitution who promise to bring home the most cash.

In a democracy, faithless to constitutional guarantees, the majority will take whatever it wants from the minority including its liberty and property.

Andrew P. Napolitano is a former professor of law and judge of the Superior Court of New Jersey who has published nine books on the U.S. Constitution.

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Tyranny of the majority: The spiraling overreach of the federal government - Washington Times

What is the association between long-term salt usage behavior and risk of premature mortality? – News-Medical.Net

In a recent study published in the European Heart Journal, researchers assessed the impact of increased salt consumption on life expectancy.

The impact of dietary salt intake on human health has always been debated. Recent studies report that sodium intake was inversely related to the risk of all-cause mortality and thus positively associated with healthy life expectancy across 181 countries globally. On the other hand, previous studies have found contradictory results stating the negative association between sodium intake and mortality risk.

In the present study, researchers assessed the correlation between the number of times a person adds salts to foods and the risk of premature mortality.

In a population-based study called the UK Biobank study, the team recruited over 0.5 million individuals from 22 assessment centers across England, Scotland, and Wales between 2006 and 2010. Based on the availability of complete data, 501,379 individuals were eligible for the main analysis.

The participants answered a questionnaire at baseline asking them if they added salt to their foods. The individuals were required to answer the question by selecting one of the five options, including: (1) never/rarely, (2) sometimes, (3) usually, (4) always, and (5) prefer not to answer. The participants were also asked if they had made any dietary changes in the last five years, which were answered by choosing one of the five options: (1) no, (2) yes, because of illness, (3) yes, because of other reasons, and (4) prefer not to answer.

The team also obtained urinary samples from the participants at baseline. Potassium and sodium levels present in the samples were detected using the ion-selective electrode method. The team subsequently log-transformed the concentrations of urinary potassium and sodium to normalize data distribution. Furthermore, the 24-hour sodium excretion was evaluated based on the urinary concentrations using the gender-specific INTERSALT equations.

The eligible participants were further asked to complete the 24-hour dietary recalls conducted based on the Oxford WebQ from 2009 to 2012 which queried the persons about their consumption of over 200 food types and more than 30 drinks over the past 24 hours. Almost 189,266 participants had complete data on the number of times they added salt to their foods, dietary information, and realistic total energy intake.

The team obtained data related to the deaths and death dates and calculated the person-years at risk from the beginning of the study to the end of the follow-up period, date of death, or 14 February 2018, whichever occurred first. Mortalities that occurred before 75 years were termed premature. Furthermore, the team constructed a life table to estimate the life expectancy of eligible participants based on: (1) population mortality rates specific to the gender and age obtained from the Office for National Statistics, (2) the sex-specific hazard ratios (HRs) of all-cause mortality in each group for which the frequencies of adding salt to foods were identified as compared to the reference cohort, and (3) the prevalence of each gender based on the frequencies of adding salt to foods.

The study results showed that participants with a higher frequency of adding salt to foods were likelier to be non-White, male, and have a higher body-mass index (BMI). Participants who added salt more often were also more likely to have cardiovascular diseases and diabetes but less likely to have hypertension and chronic kidney disease (CKD).

The team observed a graded association between a higher frequency of adding salt to foods and higher urinary sodium levels. Participants who never/rarely, sometimes, usually, and always add salt to their food had log-urinary sodium concentrations of 1.86, 1.90, 1.92, and 1.94 mmol/L, respectively. On the other hand, there was an inverse association between the frequency of salt addition and urinary potassium concentrations. Furthermore, the team found a substantial positive correlation between the frequency of salt added to foods and the evaluated 24-hour sodium excretion.

Among participants who never/rarely, sometimes, usually, and always add salt to their food, the HRs for all-cause premature mortality were 1, 1.02, 1.07, and 1.28, respectively. In the case of cause-specific mortality, a higher frequency of salt added to foods was remarkably correlated with the increased hazard of cancer mortality and cardiovascular disease mortality, but no such association was observed for respiratory mortality and dementia mortality.

The team also noted that 50-years older women who self-reported that they always added salt to their food had approximately 1.50 years less life expectancy. Men who always added salt had 2.28 years less life expectancy compared to their counterparts who rarely or never added salt to their foods.

Overall, the study findings showed that the higher frequency of adding salt to foods increased all-cause premature mortality and a decline in life expectancy.

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