Category Archives: Human Behavior

Kingdom of the Planet of the Apes Actors Had Trouble Reverting Back to Human – CBR

The graduates of "Ape School" went through a transformation to teach themselves how to best portray primates in the new movie Kingdom of the Planet of the Apes. While switching into character was unique for the actors, it was actually reverting back to human behavior that felt more strange.

In a new interview with CBR's Kevin Polowy, actors Kevin Durand and Peter Macon addressed their roles in Kingdom of the Planet of the Apes. Durand plays the villain, the bonobo Proximus Caesar, while Macon plays Raka, a wise orangutan who serves as an ally to Owen Teague's Noa. When asked about the weirdest part of going through Ape School to transition into character, Macon explained how it was more difficult to go back to human behavior at the end of the day.

"I think the weirdest thing was to come back to being a human," as Macon said. "You know, you spend your day... we'd be in there six, seven hours, and just living in this [other mindset]. [...] Sometimes longer! Because Alain Gauthier, our movement coach, would [teach us] it's part of the process too to go back to being a human, so that you can sort of feel the difference in your body, and then go back to being an ape, and go back to being a human. So, transitioning back to being a human at the end of the day, and walking up the stairs, it just didn't feel right."

"So, transitioning back to being a human at the end of the day, and walking up the stairs, it just didn't feel right."

Meanwhile, Durand frequently broke out into character throughout the entire interview with Polowy. The actor joked that he's "still in it" when talking about the "Ape School" training that was done for the primate actors. Durand also shared how he has taken his ape persona home as well, much to the enjoyment of his youngest child.

"My wife begs me to stop," Durand said. "My children, at first, my eldest was like, 'No.' But, my little one was kind of scared, and fascinated."

Demonstrating how he'd spoken to her with his Proximus Caesar voice, Durand added, "Within ten minutes, we're ape-ing around. We would play together, and it was so much fun. She would talk to me like I was Proximus."

The official synopsis for the movie reads, "Director Wes Ball breathes new life into the global, epic franchise set several generations in the future following Caesars reign, in which apes are the dominant species living harmoniously and humans have been reduced to living in the shadows. As a new tyrannical ape leader builds his empire, one young ape undertakes a harrowing journey that will cause him to question all that he has known about the past and to make choices that will define a future for apes and humans alike."

Kingdom of the Planet of the Apes is now playing in movie theaters.

Source: CBR

Many years after the reign of Caesar, a young ape goes on a journey that will lead him to question everything he's been taught about the past and make choices that will define a future for apes and humans alike.

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Kingdom of the Planet of the Apes Actors Had Trouble Reverting Back to Human - CBR

AI learned how to sway humans by watching a cooperative cooking game – Science News Magazine

If youve ever cooked a complex meal with someone, you know the level of coordination required. Someone dices this, someone sauts that, as you dance around holding knives and hot pans. Meanwhile, you might wordlessly nudge each other, placing ingredients or implements within the others reach when youd like something done.

How might a robot handle this type of interaction?

Research presented in late 2023 at the Neural Information Processing Systems, or NeurIPS, conference, in New Orleans, offers some clues. It found that in a simple virtual kitchen, AI can learn how to influence a human collaborator just by watching humans work together.

In the future, humans will increasingly collaborate with artificial intelligence, both online and in the physical world. And sometimes well want an AI to silently guide our choices and strategies, like a good teammate who knows our weaknesses. The paper addresses a crucial and pertinent problem, how AI can learn to influence people, says Stefanos Nikolaidis, who directs the Interactive and Collaborative Autonomous Robotic Systems (ICAROS)lab at the University of Southern California in Los Angeles, and was not involved in the work.

The new work introduces a way for AI to learn to collaborate with humans, without even practicing with us. It could help us improve human-AI interactions, Nikolaidis says, and detect when AI might take advantage of us whether humans have programmed it to do so, or, someday, it decides to do so on its own.

There are a few ways researchers have already trained AI to influence people. Many approaches involve whats called reinforcement learning (RL), in which an AI interacts with an environment which can include other AIs or humans and is rewarded for making sequences of decisions that lead to desired outcomes. DeepMinds program AlphaGo, for example, learned the board game Go using RL.

But training a clueless AI from scratch to interact with people through sheer trial-and-error can waste a lot of human hours, and can even presents risks if there are, say, knives involved (as there might be in a real kitchen). Another option is to train one AI to model human behavior, then use that as a tireless human substitute for another AI to learn to interact with. Researchers have used this method in, for example, a simple game that involved entrusting a partner with monetary units. But realistically replicating human behavior in more complex scenarios, such as a kitchen, can be difficult.

The new research, from a group at the University of California, Berkeley, used whats called offline reinforcement learning. Offline RL is a method for developing strategies by analyzing previously documented behavior rather than through real-time interaction. Previously, offline RL had been used mostly to help virtual robots move or to help AIs solve mazes, but here it was applied to the tricky problem of influencing human collaborators. Instead of learning by interacting with people, this AI learned by watching human interactions.

Humans already have a modicum of competence at collaboration. So the amount of data needed to demonstrate competent collaboration when two people are working together is not as much as would be needed if one person were interacting with an AI that had never interacted with anyone before.

In the study, the UC Berkeley researchers used a video game called Overcooked, where two chefs divvy up tasks to prepare and serve meals, in this case soup, which earns them points. Its a 2-D world, seen from above, filled with onions, tomatoes, dishes and a stove with pots. At each time step, each virtual chef can stand still, interact with whatever is in front of it, or move up, down, left or right.

The researchers first collected data from pairs of people playing the game. Then they trained AIs using offline RL or one of three other methods for comparison. (In all methods, the AIs were built on a neural network, a software architecture intended to roughly mimic how the brain works.) In one method, the AI just imitated the humans. In another, it imitated the best human performances. The third method ignored the human data and had AIs practice with each other. And the fourth was the offline RL, in which AI does more than just imitate; it pieces together the best bits of what it sees, allowing it to perform better than the behavior it observes. It uses a kind of counterfactual reasoning, where it predicts what score it would have gotten if it had followed different paths in certain situations, then adapts.

The AIs played two versions of the game. In the human-deliver version, the team earned double points if the soup was delivered by the human partner. In the tomato-bonus version, soup with tomato and no onion earned double points. After the training, the chefbots played with real people. The scoring system was different during training and evaluation than when the initial human data were collected, so the AIs had to extract general principles to score higher. Crucially, during evaluation, humans didnt know these rules, like no onion, so the AIs had to nudge them.

On the human-deliver game, training using offline RL led to an average score of 220, about 50 percent more points than the best comparison methods. On the tomato-bonus game, it led to an average score of 165, or about double the points. To support the hypothesis that the AI had learned to influence people, the paper described how when the bot wanted the human to deliver the soup, it would place a dish on the counter near the human. In the human-human data, the researchers found no instances of one person passing a plate to another in this fashion. But there were events where someone put down a dish and ones where someone picked up a dish, and the AI could have seen value in stitching these acts together.

The researchers also developed a method for the AI to infer and then influence humans underlying strategies in cooking steps, not just their immediate actions. In real life, if you know that your cooking partner is slow to peel carrots, you might jump on that role each time until your partner stops going for the carrots. A modification to the neural network to consider not only the current game state but also a history of their partners actions would give a clue as to what their partners current strategy is.

Again, the team collected human-human data. Then they trained AIs using this offline RL network architecture or the previous offline RL one. When tested with human partners, inferring the partners strategy improved scores by roughly 50 percent on average. In the tomato-bonus game, for example, the bot learned to repeatedly block the onions until people eventually left them alone. That the AI worked so well with humans was surprising, says study coauthor Joey Hong, a computer scientist at UC Berkeley.

Avoiding the use of a human model is great, says Rohan Paleja, a computer scientist at MIT Lincoln Laboratory in Lexington, Mass., who was not involved in the work. It makes this approach applicable to a lot of real-world problems that do not currently have accurate simulated humans. He also said the system is data-efficient; it achieved its abilities after watching only 20 human-human games (each 1,200 steps long).

Nikolaidis sees potential for the method to enhance AI-human collaboration. But he wishes that the authors had better documented the observed behaviors in the training data and exactly how the new method changed peoples behaviors to improve scores.

In the future, we may be working with AI partners in kitchens, warehouses, operating rooms, battlefields and purely digital domains like writing, research and travel planning. (We already use AI tools for some of these tasks.) This type of approach could be helpful in supporting people to reach their goals when they dont know the best way to do this, says Emma Brunskill, a computer scientist at Stanford University who was not involved in the work. She proposes that an AI could observe data from fitness apps and learn to better nudge people to meet New Years exercise resolutions through notifications (SN: 3/8/17). The method might also learn to get people to increase charitable donations, Hong says.

On the other hand, AI influence has a darker side. Online recommender systems can, for example,try to have us buy more, or watch more TV, Brunskill says, not just for this moment, but also to shape us into being people who buy more or watch more.

Previous work, which was not about human-AI collaboration, has shown how RL can help recommender systems manipulate users preferences so that those preferences would be more predictable and satisfiable, even if people didnt want their preferences shifted. And even if AI means to help, it may do so in ways we dont like, according to Micah Carroll, a computer scientist at UC Berkeley who works with one of the paper authors. For instance, the strategy of blocking a co-chefs path could be seen as a form of coercion. We, as a field, have yet to integrate ways for a person to communicate to a system whattypes of influence they are OK with, he says. For example, Im OK with an AI trying to argue for a specific strategy, but not forcing me to do it if I dont want to.

Hong is currently looking to use his approach to improve chatbots (SN: 2/1/24). The large language models behind interfaces such as ChatGPT typically arent trained to carry out multi-turn conversations. A lot of times when you ask a GPT to do something, it gives you a best guess of what it thinks you want, he says. It wont ask for clarification to understand your true intent and make its answers more personalized.

Learning to influence and help people in a conversation seems like a realistic near-term application. Overcooked, he says, with its two dimensions and limited menu, is not really going to help us make better chefs.

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AI learned how to sway humans by watching a cooperative cooking game - Science News Magazine

We can’t combat climate change without changing minds. This psychology class explores how. – Northeastern University

Published on

March 7, 2024

PSYC-4660: Humans & Nature is part of a broader academic push at Northeastern to explore the intersection of environmental science and cognitive processing and how it can lead to tangible changes.

When Northeastern professors John Coley and Brian Helmuth tell their students to introduce themselves, they really mean it.

Its a clammy Monday afternoon in mid-January, and the 15 members of PSYC-4660 Humans & Nature: The Psychology of Social-Ecological Systems on Northeastern Universitys Boston campus are taking turns in front of a projector. Theyre going through detailed PowerPoint slides outlining their majors, family backgrounds, college resumes thus far, hobbies, dogs and cats. Some grew up going to grandparents farms and camping every weekend in rural New England; one works part time for a company that sells carbon credits. Eshna Kulshreshtha, born and raised in California, talks about the small arguments she and her Indian immigrant parents have about recycling.

Ive never had a class where we spent an hour just doing introductions, says Kulshreshtha, a second-year marine science major, in an interview a few days later.

In another context it might be oversharing; here it has a point. The central argument of the class is that our personal backgrounds, behaviors and resulting worldviews may hold the key to saving the planet.

A new offering for the spring 2024 semester, PSYC-4660 is a seminar in cognition, a subset of psychology that covers how people encode, represent and process information from the environment in the brain, according to Coley, a psychology professor with a dual appointment in environmental science. Humans & Nature zeros in on how those things inform our interactions with the natural world, and the in-depth intros underscore just how different those can be from person to person based on their backgrounds.

Cataloged as an upper-level psychology class but available to any interested undergrad, the seminar is also part of a larger push at Northeastern to explore the relationship between brain and environmental sciences, including collaborative research papers and a new Ph.D. program currently accepting applicants for the coming fall.

I have become more and more convinced that this is a critical component to getting people and, honestly, agencies and governments to act in a more sustainable way, Coley says.

A marine science professor based at Northeasterns Nahant campus, Helmuth researches how climate change impacts coastal ecosystems. He has spent a large chunk of his career underwater, and more of it than he would like watching many of those ecosystems disappear. In his view, many solutions to issues affecting the planet are clear-cut; how to effectively implement them at scale is another story.

In most environmental problems the issue is not the science, he says a few days after the class meeting. Weve got a lot of solutions. Its the human behavior side thats hard to change. In policy, theres a lot of experimentation, but its kind of trial and error.

Coley is a developmental psychologist by training; early in his career, he researched how very young children categorize the natural world. The first big study I did at Northeastern looked at kids from across Massachusetts from inner-city Boston and Somerville to some very rural places in Western Massachusetts and how [their] experiences led to differences in how kids think about relations among plants and animals, he says. Further research examined how those backgrounds affected college kids learning in biology and other life science classes.

In most environmental problems the issue is not the science. Weve got a lot of solutions. Its the human behavior side thats hard to change.

The two initially met through Nicole Betz, a graduate student in Coleys lab. Last year, the three co-authored a paper on how human exceptionalism the idea that humans are different and set apart from other organisms can hinder sustainable behavior.

Humans & Nature is a further exploration of that type of academic research in a classroom setting with readings, lectures and a heavy emphasis on class discussions, all dealing with questions about how we think comes to bear on biodiversity preservation, food systems and climate change, according to the syllabus.

For the first few weeks, for example, the course content focuses on biodiversity conservation, or preserving the richness of species on Earth. An academic paper by sustainability scientist Thomas McShane explores the trade-offs between preserving biodiversity and human well-being; another, from 2019, explores possible links between a richer array of species and increased mental health in humans. Research from 2016 by a trio of ecologists in the academic journal Global Environmental Change focuses on urban biodiversity, outlining possible ways to marry development and conservation of natural environments in an economically equitable way.

The class is not proscriptive: I dont think there are specific misconceptions that were trying to puncture, Helmuth says. A lot of this is helping the students identify complexities in their different worldviews as they relate to those topics. Id be very surprised, even with a class this size, if they were all at the same starting point.

After introductions, the class breaks into small groups to discuss the assigned reading: a thin textbook called Human Dependence on Nature: How to Help Solve the Environmental Crisis by Haydn Washington. They talk together at length about collectivism and the sense of community in small, rural villages around the world and how it contrasts to the individualist, comparatively isolated routines of Western European and American societies.

We can follow a behavior but not value it in the United States, a student muses. I think its harder. In other societies where [people are more immediately affected by] the general health of their community, it might be easier to implement a belief in sustainability and helping the world around you.

The conversation isnt just geopolitical. Its a group in their early 20s, and millennials catch strays for being off-trend and having a collectively dire outlook on global warming. I recently saw a video that was like Stanley cups are over because the moms have gotten to it now its not cool, one student says. Were getting sick of things a lot faster, and overconsumption speeds up.

Theres a shift in our younger generation thats more inclined towards an understanding and appreciation for nature, which was lost on the millennial population because there was so much talk about climate change and overconsumption that everyone got overwhelmed, says another.

Kulshreshtha has experienced these types of vast differences in attitude even within her family. She grew up frequently visiting relatives in New Delhi and Noida in India. There, she explains, sustainability and eco-friendliness arent talked about nearly as much as they are in the United States, but not because people dont care about it. Rather, sustainable habits and practices are more baked into daily life.

Especially now, in the United States, people constantly pushing you to think about, like, Hey, make sure youre recycling the right thing, she says. Thats always on the forefront of your mind is this thing Im doing environmentally friendly?

With my extended family, its not something that they talk about, but theyre not being as harmful to the environment in their daily lives, she continues. My family in India still gets milk delivered every morning from the milkman, they put the bottles outside again every day. If you get groceries, youre not getting individual plastic bags for your broccoli and carrots. The street food vendors use bowls made out of leaves and wooden utensils. All these things are already integrated into Indian culture, so its not like you have to be actively thinking about how much plastic youre using every day.

Helmuth and Coley both think those types of insights can have direct impacts, particularly at a place like Northeastern. Environmental psychology with a focus on the natural world isnt a totally new concept, but tying it directly to human behavior and policy in an academically rigorous way is a next step. The course dovetails with research the two men have collaborated on, with implications for real-world scenarios like science education curricula and aiding the federal government on more effective environmental messaging and policy (Helmuth was a co-author of the White Houses most recent National Climate Assessment, released in November).

In the fall, Northeastern will begin admission to a new Ph.D. program in Human Behavior and Sustainability Sciences that integrates traditional core requirements of psychology and environmental science graduate programs. The hope is that this sort of interdisciplinary training could lead to more collaborations like theirs. Someone in psychology who [specializes in] decision-making and someone who studies salt marsh restoration could work together, Coley says. We want to provide Ph.D. students with structured opportunities to make those connections across fields.

And theyre optimistic about the future possibilities those collaborations could lead to. One advantage of teaching someplace like this is that these students are going to take over the world, Helmuth says. We already have a lot of students through co-ops working in the city of Boston, in state offices, at NASA. Anything we do in a classroom here is going to multiply itself.

Schuyler Velasco is a Northeastern Global News Magazine senior writer. Email her at s.velasco@northeastern.edu. Follow her on X/Twitter @Schuyler_V.

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We can't combat climate change without changing minds. This psychology class explores how. - Northeastern University

Bees Reveal a Human-Like Collective Intelligence We Never Knew Existed – ScienceAlert

The humble bumblebee is proof that brain size isn't everything.

This little insect with its wee, seed-sized brain has shown a level of collective intelligence in experiments that scientists thought was wholly unique to humans.

When trained in the lab to open a two-step puzzle box, bumblebees of the species Bombus terrestris could teach the solution to another bee that had never seen the box before.

This naive bee would not have solved the puzzle on its own. To teach the 'demonstrator' bees the non-intuitive solution in the first place, researchers had to show them what to do and offer them a reward after the first step to keep them motivated.

"This finding challenges a common opinion in the field: that the capacity to socially learn behaviors that cannot be innovated through individual trial and error is unique to humans," write the team of researchers based in the United Kingdom and United States.

Humans have a long history of 'moving the goalposts' on what sets our species apart from all others.

Once, it was thought that humans were the only animals with culture. But 'viral' songs among sparrows, the evolving dialects and traditions of whales, the regional hunting strategies of orcas, and the learned tool tricks of apes, crows, and dolphins, all suggest that socially transmitted behaviors are also present in animal societies, too.

Some of these cultural behaviors even show signs of refinement and improvement over time. Homing pigeons, for instance, learn from each other and adjust their culture's flight paths year on year.

An influential way to move the goalposts on human intelligence is to say that humans are unique from other animals because we can learn things from each other that we could not invent independently.

Think of the device you are reading this article on right now. No one human can invent all its parts and mechanics from scratch on their own and in one lifetime. It's taken decades of work and refinement to get to this advanced stage. Even the very act of reading is a skill that generations of humans have built upon little by little.

Obviously, no animal can put together an iPhone or read an article on animal intelligence. But at a basic level, bumblebees join chimpanzees in "cast[ing] serious doubt on this supposed human exceptionalism," writes Alex Thornton, an ecologist at the University of Exeter, in a review of the bumblebee research for Nature.

Chimpanzees have large brains and rich cultural lives, but the discovery among bumblebees, Thornton argues, is "all the more remarkable because it focuses not on humanity's primate cousins, but on an animal with a brain that is barely 0.0005 percent of the size of a chimpanzee's."

Underestimated for decades, largely because of their size, bumblebees are finally getting their due.

Recent experiments in the lab show these bees can learn from each other, use tools, count to zero, and perform basic mathematical equations.

The collective intelligence of their hive mind is also not to be dismissed.

To test it, behavioral scientist Alice Bridges from Queen Mary University of London and colleagues housed colonies of bumblebees with a two-step puzzle for a total of 36 or 72 hours over 12 or 24 consecutive days, with no human help.

After all that time, the bees could not figure out how to get to the sugary reward. Bumblebees spend on average about 8 days foraging in their lifetimes, so it's as if they had up to a third of their lifetime foraging time to work on the puzzle.

In the image below, you can see the puzzle. The yellow circle contains a drop of sugar under a plastic lid. Bees can get to it by pushing the red tab, but only once the blue tab has been pushed out of the way.

It took a human to painstakingly show them the way, and this was only possible using an extra reward. But once one bee figured it out, they could teach others how to move the two tabs to retrieve a sugary treat.

A similar experiment on chimps was also published recently in Nature Human Behavior. Both the vertebrate and invertebrate case studies showed a sharing of ideas that were exceptionally hard to learn alone.

Of course, this behavior wasn't observed in the wild. It had to be taught to the bees and chimps first. But the findings leave open the possibility that if there were a rare, once-in-a-lifetime innovator in chimp or bee society an Einstein among bees their ideas might stick around in animal culture and be used for generations to come.

Bees' famous honey waggle dance, pointing out the distance, direction, and quality of sources of food, for instance, is a behavior that was once thought to be purely instinctive, but it now appears to be somewhat shaped by social influences.

In 2017, researchers also trained bumblebees to roll a ball into a goal for a reward. To score, the insects had to learn from each other and remedy their previous mistakes. And so they did.

The newest experiment, Thornton writes, "suggests that the ability to learn from others what cannot be learnt alone should now join tool use, episodic memory (the ability to recall specific past events) and intentional communication in the scrapheap" of explanations for human cognition and culture.

The study was published in Nature.

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Bees Reveal a Human-Like Collective Intelligence We Never Knew Existed - ScienceAlert

Franciscan AI expert warns of technology becoming a ‘pseudo-religion’ – Detroit Catholic

ROME (CNS) -- Artificial intelligence risks giving technology a "pseudo-religion" status by shaping the way people engage with information and reality, a leading expert on artificial intelligence said.

Interacting with artificially intelligent large language models like OpenAI's ChatGPT could "fracture us from reality," Franciscan Father Paolo Benanti, an expert on artificial intelligence and professor of moral theology at the Pontifical Gregorian University, said March 7 at a conference organized by the Pontifical Academy of Theology.

Relying on such models could "reduce our capacity to have a strengthened, more sophisticated (way of) reasoning," he said, since people would have less need to engage in the focused thought required for tasks that can be completed by artificially intelligent technology.

Artificial intelligence, he said, can alter humanity's relationship with reality "to the point that (humanity's) desire for control, which satisfies the anxiety typical of the human condition, could take on a tendency toward a pseudo-religion regarding machines."

The theologian said that as machines become increasingly "humanized," humans also become increasingly "mechanized." As an example, he suggested considering a boy performing a task on a phone. "Is it his fingers that control the screen or are the phone's notifications controlling the behavior of the boy?" he asked.

"External causes such as interactions with machines can change our behavior," he said.

By using algorithms that consume and process the vast amounts of data humans produce, "the machine is not only able to predict our behavior, but is also able to produce our behavior," he said.

But unlike laws created by governments, which are also intended to influence human behavior, algorithms are developed by private companies that have financial earnings and not the public good as their primary objective, he said, citing as an example the world of e-commerce, which suggests products to users based on collected data about their shopping history and interests.

Father Benanti said that the "knowledge" produced by artificial intelligence can make data the principal way people making sense of and exercise control over their reality -- which is what he said religious thinking seeks to do -- and he said theology must confront such a rapid transformation in the way people view the world around them.

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Franciscan AI expert warns of technology becoming a 'pseudo-religion' - Detroit Catholic

Freshwater resources at risk thanks to human behavior – messenger-inquirer

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Freshwater resources at risk thanks to human behavior - messenger-inquirer

Astrocytes Play Critical Role in Regulating Behavior – Neuroscience News

Summary: Researchers made a groundbreaking discovery in identifying a unique group of astrocytes, located in the brains central striatum, that play a crucial role in regulating behaviors linked to neuropsychiatric disorders. This distinct subset of astrocytes expresses the gene Crym, coding for -crystallin, a protein associated with various human diseases.

By experimentally reducing Crym expression in these astrocytes, the study observed increased repetitive behaviors in mice, akin to human perseveration seen in conditions like autism and OCD. This novel finding not only challenges the neuron-centric view of brain function but also opens up new avenues for potential treatments targeting specific astrocyte populations.

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Source: UCLA

UCLA Health researchers have discovered a group of specialized support cells in the brain that can regulate behaviors associated with human neuropsychiatric disorders.

Thestudy, published in the journalNature, focused on a group of cells known as astrocytes star-shaped cells that tile the central nervous system and provide a support structure for the neural communication networks.

While neurons have long been understood to have primary control of behavior, the study found that a distinct group of astrocytes located deep in the central region of the brain, known as the central striatum, may also regulate communications between neurons.

Unlike other astrocytes, this group of astrocytes express the geneCrym, which encodes for the protein known as -crystallin. This protein has been associated with several human diseases including neuropsychiatric disorders, but its influence on brain function has remained largely unknown.

Several years ago the lab identified that astrocytes in the striatum expressCrym. It was my job to find out what it did. By reducing expression of this gene in astrocytes of the central striatum, I uncovered mechanisms related to a specific behavior called perseveration, saidMatthias Ollivier, the studys first author and postdoctoral scholar at theDavid Geffen School of Medicine at UCLA.

In the study, researchers genetically reduced the expression of the gene in this group of astrocytes in mice. Studying the behavior of mice, the researchers found they had significant increases in repetitive behavioral patterns or activities that serve little purpose or made it difficult for the mice to transition to other activities.

This behavior, known as perseveration, is associated with neurological and psychiatric disorders including autism, obsessive-compulsive disorder, Huntingtons disease and Tourette syndrome.

The study found thatCrym-positive astrocytes in the central striatum regulated neurotransmitter communication at synapses from the cortex to the center of the brain within the striatum.

At a basic biology level, the study provides evidence that distinct types of astrocytes have important neurobiological functions, saidBaljit Khakh, the senior author of the study and professor of physiology and neurobiology at the David Geffen School of Medicine at UCLA.

Researchers say the findings could be starting points in the development of potential therapies to alleviate perseveration in different disorders. Further research is underway to understand the interactions and signaling cascades regulated by -crystallin.

Author: Will Houston Source: UCLA Contact: Will Houston UCLA Image: The image is credited to Neuroscience News

Original Research: Open access. Crym-positive striatal astrocytes gate perseverative behaviour by Matthias Ollivier et al. Nature

Abstract

Crym-positive striatal astrocytes gate perseverative behaviour

Astrocytes are heterogeneous glial cells of the central nervous system. However, the physiological relevance of astrocyte diversity for neural circuits and behaviour remains unclear.

Here we show that a specific population of astrocytes in the central striatum expresses -crystallin (encoded byCrymin mice andCRYMin humans)that is associated with several human diseases, including neuropsychiatric disorders.

In adult mice, reducing the levels of -crystallin in striatal astrocytes through CRISPRCas9-mediated knockout ofCrymresulted in perseverative behaviours, increased fast synaptic excitation in medium spiny neurons and dysfunctional excitatoryinhibitory synaptic balance.

Increasedperseveration stemmed from the loss ofastrocyte-gated control of neurotransmitter release from presynaptic terminals of orbitofrontal cortexstriatum projections. We found that perseveration could be remedied using presynaptic inhibitory chemogenetics, and that this treatment also corrected the synaptic deficits.

Together, our findings reveal converging molecular, synaptic, circuit and behavioural mechanisms by which a molecularly defined and allocated population of striatal astrocytes gates perseveration phenotypes that accompany neuropsychiatric disorders.

Our data show thatCrym-positive striatal astrocytes have key biological functions within the central nervous system, and uncover astrocyteneuron interaction mechanisms that could be targeted in treatments for perseveration.

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Astrocytes Play Critical Role in Regulating Behavior - Neuroscience News

Freshwater resources at risk thanks to human behavior – Sunnyside Sun

(Photo by Pixabay via Pexels)

By Isobel Williams via SWNS

Earths freshwater cycle has been knocked out of its stable state by man, warns a new study.

The research shows that human pressures - such as dam construction, large-scale irrigation and global warming- have altered freshwater resources to such an extent that their capacity to regulate vital ecological and climatic processes is at risk.

The study, published in the journal Nature Water, explains that for the past century, humans have been pushing the Earths freshwater system far beyond the stable conditions that prevailed before industrialization.

The international research team, led by Aalto University in Finland, notes that this is the first time that global water cycle change has been assessed over such a long timescale with an appropriate reference baseline.

To get their results the researchers calculated monthly streamflow and soil moisture at a spatial resolution of roughly 50x50 kilometers using data from hydrological models that combine all major human impacts on the freshwater cycle.

As a baseline, they determined the conditions during the pre-industrial period (1661-1860) and compared the industrial period (1861-2005) against this baseline.

Their analysis revealed an increase in the frequency of exceptionally dry or wet conditions deviations in streamflow and soil moisture.

Overall, they saw that the global land area experiencing deviations has nearly doubled compared with pre-industrial conditions.

Vili Virkki, a doctoral researcher at Aalto University, said: We found that exceptional conditions are now much more frequent and widespread than before, clearly demonstrating how human actions have changed the state of the global freshwater cycle.

(Photo by Artem Podrez via Pexels)

In their study, the researchers were able to explore geographical differences in these deviations.

They found that exceptionally dry streamflow and soil moisture conditions became more frequent in many tropical and subtropical regions, while many boreal and temperate regions saw an increase in exceptionally wet conditions, especially in terms of soil moisture.

They also found that there were more complex patterns in many regions with a long history of human land use and agriculture.

For example, the Nile, Indus and Mississippi River basins have experienced exceptionally dry streamflow and wet soil moisture conditions, indicating changes driven by irrigation.

Dr. Miina Porkka said: Using a method thats consistent and comparable across hydrological variables and geographical scales is crucial for understanding the biophysical processes and human actions that drive the changes were seeing in freshwater.

The team hopes that their findings will better inform future research on changes in the freshwater cycle.

Associate Professor Matti Kummu added: Understanding these dynamics in greater detail could help guide policies to mitigate the resulting harm but our immediate priority should be to decrease human-driven pressures on freshwater systems, which are vital to life on Earth.

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Freshwater resources at risk thanks to human behavior - Sunnyside Sun

Freshwater resources at risk thanks to human behavior – Blue Mountain Eagle

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Freshwater resources at risk thanks to human behavior - Blue Mountain Eagle