Category Archives: Immunology

I have a PhD in immunology and this is how I keep my daughter from getting sick during the winter – Business Insider

captionFlu season is here, which means families need to take extra precautions to keep children from getting sick.sourceGetty

Flu season is here. But Im not all that worried. I have a PhD in immunology and have put that training to good use in protecting my now 5-year-old daughter from getting sick. I take all the standard precautions to safeguard against the sniffles, by vaccinating and practicing sensible hand washing (while still largely avoiding hand sanitizers), but theres still a lot more to do to keep sickness at bay.

One issue that may affect your childs ability to fight infection is a Vitamin D deficiency. Vitamin D has a three-fold role in the immune system it fights infections and curbs autoimmune processes as well as inflammation. Vitamin D deficiency increases risks for a number of health issues, including repeatedly falling ill.

The main source of Vitamin D is exposure to sunlight. Vitamin D deficiency is somewhat common, and worsens in winter when people dont get outside as much.

Between 12% and 24% of infants, children, and adolescents are Vitamin D deficient, with breastfed babies being at a higher risk. The American Academy of Pediatrics (AAP) recommends that in their first year of life, babies get 400 IU of Vitamin D daily. The AAP advises parents to give an oral Vitamin D supplement to breastfeeding infants and to those who consume less than 1 liter of infant formula a day.

By conservative estimates, children and adolescents need 600 IU each day. Its ideal for children and adolescents to get Vitamin D from natural sources, experts say.

If youre concerned that your child isnt getting enough from sunlight exposure, or is showing warning signs like being tired or falling ill often, consult your pediatrician about a potential Vitamin D deficiency.

I give my daughter the recommended dose all year round with a probiotic called BioGaia that is fortified with Vitamin D.

Omega 3s play a crucial role in brain and vision development, and were just beginning to understand the role they play in the immune system. As with most things, getting some but not too much is prudent. Ensuring your childs diet has some omega 3s, either regularly through food including wild-caught salmon and walnuts or supplementing periodically is a good idea. A breastfeeding mom should also eat a generous amount of foods containing omega 3s so that the nutrients are transferred to the baby.

Part of my childs regular maintenance protocol is taking a probiotic Lactobacillus reuteri DSM 17938, marketed as Biogaia. Originally discovered in breastmilk, part of its potential protective mechanism is the broad spectrum of antibiotic (reuterin) it produces, which may limit colonization by pathogenic bacteria.

In small research studies, it has been shown to protect against both GI tract and respiratory infections, reduce colic in breastmilk fed infants, and potentially protect against cavities. Taken together, the evidence suggests the probiotic microorganism may improve health in a variety of contexts.

Given the limited evidence, there is no recommendation for regular use. But since Biogaias safety is well-established and the cost is reasonable (about $30 for a two-month supply), I elected to give it regularly to my child since birth, and will continue doing so. (Be aware: the majority of probiotics have minimal to no research to back up their claims).

Turmeric has been used for medicinal purposes in India for centuries. As modern science is now discovering, its main component curcumin has anti-inflammatory, anti-viral, anti-microbial, and anti-cancer properties. It could potentially help in fending off both viral and bacterial infections and combat the deleterious effects of inflammation.

However, drinking a turmeric extract in water (in say, a latte or smoothie) is close to useless because it absorbs poorly when dissolved in water. What little is absorbed is then rapidly eliminated by the liver.

Turmeric should be dissolved in oil, ideally, for absorption. For maximum effect, pair it with piperine, a component of black pepper that prevents the rapid elimination.

When my daughter is ill, I serve her either a home-brew of turmeric in coconut oil with black pepper (taken with manuka honey, milk, or both), or a supplement that contains liposome-encapsulated turmeric plus piperine three to four times a day until her fever breaks.

Elderberry extracts have also been used medicinally for centuries. In studies in vitro, and in mice, and humans, elderberry has been shown to help reduce the severity and length of the flu, and can help in fighting other viral infections too.

Some parents go so far as to give elderberry to their children every day. However, this is both unnecessary and potentially dangerous: Elderberry has medicinal properties that could actually interfere with normal functioning. For example, elderberry extracts inhibit functioning of ribosomes, which are required for protein production. They may exacerbate autoimmune diseases and their long-term safety has not been studied.

Consult with your pediatrician to determine the appropriate dose for your child.

How has all this helped? While it is impossible to be sure, I can say for certain that my daughter has never had ear infections, colic, or constipation. Weve almost never had an infection that required antibiotics. Illness rarely strikes, and when it does, it subsides quickly. We have gone years without a fever, and when it comes, it usually resolves within 24 hours.

Thats good enough for me.

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I have a PhD in immunology and this is how I keep my daughter from getting sick during the winter - Business Insider

AgilVax to Present Positive Preclinical Data for Monoclonal Antibody Targeting xCT at the American Association for Cancer Research’s Tumor Immunology…

ALBUQUERQUE, N.M.--(BUSINESS WIRE)--AgilVax Inc., a biopharmaceutical company that discovers and develops targeted antibody-based therapeutics, announced today that preclinical data describing M5, the Companys monoclonal antibody targeting xCT, will be presented by Dr. Salameh at the American Association for Cancer Researchs Tumor Immunology and Immunotherapy Conference being held at the Boston Marriott Copley Place in Boston, MA.

Title:

Development of a monoclonal antibody targeting xCT/SLC7A11 expressed in metastatic cancer cells

Poster Session:

Poster Session B

Session Date:

Tuesday, November 19

Board Number (poster number):

B37

Time:

4:30 p.m. to 7:00 p.m.

Session Location:

Back Bay

We are pleased with our continued progress on developing multiple solutions to target cancer cells overexpressing xCT and thrilled to have the opportunity to showcase our advancements in a poster presentation at such a prestigious meeting, said Dr. Joseph Patti, President and CEO of AgilVax. Dr. Patti further stated, xCT overexpression occurs in several cancers leading to metabolic changes that reprograms cells for growth and progression. AgilVaxs antibody-based therapeutics have shown reduction of primary tumor formation and lung metastases illustrating the potential to create durable responses in patients suffering from colorectal and other metastatic cancers.

About AgilVax

AgilVax is a biopharmaceutical company that discover and develops targeted antibody-based products to treat multiple types of cancer. The Company has three development programs; an unmodified monoclonal antibody (mAb) targeting xCT, an antibody-drug conjugate targeting xCT, and AX09, a VLP-based xCT vaccine currently in cGMP production.

For more information, please visit http://www.agilvax.com

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AgilVax to Present Positive Preclinical Data for Monoclonal Antibody Targeting xCT at the American Association for Cancer Research's Tumor Immunology...

Immunology Market 2019 production, revenue, price, market share and growth rate upto 2025 – Press X Now

The Immunology market report offers an in-depth analysis of the on-going trends, Immunology Market drivers, different opportunities and high-growth areas which would help clients to articulate Immunology market strategies according to the current and future industry trends. The Immunology market study also covers the regional and global analysis of this industry. Furthermore, it examines and meanwhile, represents the worldwide Immunology market size of the significant players in each region around the different corner of the world.

Request a sample copy of this report at: https://marketresearchexpertz.com/report/global-immunology-market-28675#request-sample

Reportedly, the global Immunology market report accounted for xx billion in 2018 and it is projected to gather xx billion US$ by 2026, along with a growing CAGR of xx % during the forecast timeframe. Several factors including increasing demand for upgrading of the Immunology market, rising demand of the industry from developing economies, and expanding the use of Immunology market over distinct sectors are propelling the universal market.

Key Manufacturers functioning in this market are:AbbVieAmgenF. Hoffmann-La RocheJohnson & JohnsonBionor PharmaCelgeneCellectar BioscienceseFFECTOR Therapeutics

Global Immunology market segregation by type:Immuno BoostersImmunosuppressants

The Application of Immunology market can be split into:Autoimmune DiseasesOncologyOrgan TransplantationOthers

The elaborated study delivers a brief appraisal of the Immunology market that helps stakeholders to gain a solid base in this industry. The main motive of the Global Immunology market 2019 report is to offer industry investors, customers, and company officials with important statistics to assist them to create reliable industrial decisions related to the essential opportunities in the Immunology market.

This research study also pinpoints business insights and offers an analysis of the extremely significant trends that are anticipated to affect the Immunology market outlook from the year 2019 to 2026. The report also incorporates the production capacity, value chain structure, raw material sources as well as suppliers, import/export, product portfolios, and technology adoptions. Their financial status is also analyzed in the worldwide Immunology market report which studies pricing structure, growth rate, gross margin, fiscal ratios, product value, cash flow, sales volume and much more. The evaluation of the Immunology market also promotes clients to grab a clear understanding of the Immunology industry position at global level, strengths and weakness of their rivals too.

Browse More Details: https://marketresearchexpertz.com/report/global-immunology-market-28675

The research report on the Global Immunology market will surely help major market players as well as new entrants to understand the international industry in detail. Moreover, this study also encourages industry vendors to decide their business strategies and work hard to achieve their proposed business aims.

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Immunology Market 2019 production, revenue, price, market share and growth rate upto 2025 - Press X Now

CSU lands $1.2 million in NIH funding to advance work on a new tuberculosis vaccine – Source

At CSU, the research will include a multidisciplinary team of at least 20 researchers, students and staff, including Assistant Professors Michael Lyons and Brooke Anderson, Research Scientists Carolina Mehaffy and Andres Obregon Henao, Associate Professor Diane Ordway, and Corey Broeckling, director of the Proteomics and Metabolomics Facility.

Henao-Tamayo, whose TB research has been focused on vaccines, said the project aims to combine expertise from all over the world. It will include experiments to better understand previous research she conducted in collaboration with the late Ian Orme, a CSU University Distinguished Professor, to study environmental mycobacteria, which live in water and soil, and how these organisms may interfere immunologically with the protection that the BCG vaccine provides against TB.

Podell, who earned doctorates in veterinary medicine and pathology from CSU, said the initiative will be perhaps the most comprehensive pathology assessment of vaccine and TB immunity ever done.

Podell and Henao-Tamayo said that the award reflects not only the outstanding reputation of CSUs Mycobacteria Research labs, but also provides a boost of recognition for the program.

Brendan and I were both trained in these labs, and were now leading the charge on this new research, said Henao-Tamayo.

Additional partners include Oxford University; Public Health England; Statistical Center for HIV/AIDS Research and Prevention at Fred Hutchinson Cancer Research Center; Ragon Institute of MGH, MIT and Harvard; Denver Veterans Affairs Medical Center; National Jewish Health in Denver, and La Jolla Institute for Immunology.

NIAID recently awarded contracts totaling $30 million for the first year to provide up to seven years of support for three Immune Mechanisms of Protection Against Mycobacterium tuberculosis (IMPAc-TB) Centers. The Centers aim to better explain the immune responses required for protection from TB-causing Mycobacterium tuberculosis bacteria. Harvard T.H. Chan School of Public Health and Seattle Childrens Hospital will lead research for the other two centers.

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CSU lands $1.2 million in NIH funding to advance work on a new tuberculosis vaccine - Source

Gossamer Bio Announces Participation in the Guggenheim Healthcare Talks Neuro/Immunology Day – Yahoo Finance

SAN DIEGO--(BUSINESS WIRE)--

Gossamer Bio, Inc. (GOSS), a clinical-stage biopharmaceutical company focused on discovering, acquiring, developing and commercializing therapeutics in the disease areas of immunology, inflammation and oncology, today announced that Sheila Gujrathi, M.D., Chief Executive Officer and Co-Founder, will participate in a fireside chat at the Guggenheim Healthcare Talks Neuro/Immunology Day on Monday, November 18 at 1:00 p.m. ET.

A live webcast of the presentation will be available on the Events and Presentations page in the Investors section of the companys website at https://ir.gossamerbio.com. A replay of the webcast will be archived on the companys website for 90 days following the presentation.

About Gossamer Bio

Gossamer Bio is a clinical-stage biopharmaceutical company focused on discovering, acquiring, developing and commercializing therapeutics in the disease areas of immunology, inflammation and oncology. Its goal is to be an industry leader in each of these therapeutic areas and to enhance and extend the lives of patients suffering from such diseases.

View source version on businesswire.com: https://www.businesswire.com/news/home/20191114005228/en/

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Gossamer Bio Announces Participation in the Guggenheim Healthcare Talks Neuro/Immunology Day - Yahoo Finance

Anaphylaxis patients forced to wait more than a year for testing – The Canberra Times

news, latest-news, allergies, allergy, anaphylaxis, food allergies, allergy inquiry, immunology

Those living with life-threatening allergies are being forced to wait up to more than a year just to receive treatment, with experts saying wait times are set to get even worse. As the number of adults being diagnosed with anaphylaxis increases, immunologists and allergy specialists are reporting they are often unable to keep up with demand for testing and treatment. Allergy and Anaphylaxis Australia chief executive Maria Said said allergy sufferers seeking a diagnosis and specialist testing from immunologists are being put at risk due to the increased wait times. "When you have a life-threatening reaction, it could be between 12 and 18 months before an appointment, and that's really unacceptable considering the impact that allergic diseases have on people's quality of life," Ms Said said. "This has the potential to be a lot worse." A study from the Australian Society of Clinical Immunology and Allergy found 10 per cent of infants, up to 8 per cent of children and 2 per cent of adults reported having some form of food-related allergy. A National Health Survey from 2015 also found 3.1 per cent of Australians reported an "undefined allergy", with other forms of anaphylaxis including exposure to mould, insect bites or latex. Ms Said said increased wait times were being seen across Australia, with even longer wait times out of the major capital cities. A spokeswoman for Canberra Health Services said data on average wait times to see ACT-based immunologists was not collected. "Immunologists also deal with patients with other conditions, including serious autoimmune and inflammatory diseases and immune deficiencies," the spokeswoman said. "As a result, there is considerable demand for appointments. There are six immunologists employed by Canberra Health Services, all with part-time appointments." Canberra immunologist Dr Raymond Mullins said while wait times vary from state to state, public hospital outpatient waiting lists are normally more than 12 months. "Food allergies and anaphylaxis have moved from a marginal phenomena to an ongoing public health issue for an increasing proportion of the population and their caregivers," Dr Mullins said. "This has implications in terms of cost of care, the need for medical visits and review, the use and availability of emergency medication such as EpiPens." While data from the ACT is not available, figures from Victoria showed a median waiting time of more than 100 days to access immunologists for allergy testing. Dr Mullins said more people were in need of seeing immunologists as children who developed allergies got older. "Young children who have nut allergies will generally still have persistent food allergy 80 per cent time," he said. "That means we have an ageing population of teenagers and young adults with persistent food allergy at greater risk of having more serious reactions including fatalities." Ms Said said as more adults were experiencing severe allergies, many immunology clinics have been unable to keep up with demand, with many clinics only specialising in paediatrics. "There's only a handful of public clinics, and most are specifically for children, yet there's a growing number of adults with allergic diseases," she said. "It's very concerning because allergic diseases can't be cured and it has to be managed, and people need to be educated on how it can be managed." READ MORE: The access to treatment for those with anaphylaxis forms part of a federal government inquiry into severe allergies. In its submission to the inquiry, the federal Health Department said Australia had one of the highest rates of allergies and anaphylaxis in the world. "Available evidence from hospital admissions for anaphylaxis indicates the prevalence has increased in many western countries, including Australia," the department said. "Total hospital admissions rates for all causes of anaphylaxis increased by 8 per cent each year between 1997 and 2013." The Australian Society of Clinical Immunology and Allergy has told the inquiry the current access process for immunology testing was time-consuming and complicated, calling for access to be simplified. Ms Said said more public clinics were needed in order to reduce wait times for those with anaphylaxis. "We need them especially in rural and remote areas to allow for greater access to an accurate diagnosis and accurate information on allergy management," she said.

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November 18 2019 - 4:30AM

Those living with life-threatening allergies are being forced to wait up to more than a year just to receive treatment, with experts saying wait times are set to get even worse.

As the number of adults being diagnosed with anaphylaxis increases, immunologists and allergy specialists are reporting they are often unable to keep up with demand for testing and treatment.

Allergy and anaphylaxis patients are being forced to wait months to see public immunologists and specialists. Picture: Elesa Kurtz

Allergy and Anaphylaxis Australia chief executive Maria Said said allergy sufferers seeking a diagnosis and specialist testing from immunologists are being put at risk due to the increased wait times.

"When you have a life-threatening reaction, it could be between 12 and 18 months before an appointment, and that's really unacceptable considering the impact that allergic diseases have on people's quality of life," Ms Said said.

"This has the potential to be a lot worse."

A study from the Australian Society of Clinical Immunology and Allergy found 10 per cent of infants, up to 8 per cent of children and 2 per cent of adults reported having some form of food-related allergy.

A National Health Survey from 2015 also found 3.1 per cent of Australians reported an "undefined allergy", with other forms of anaphylaxis including exposure to mould, insect bites or latex.

Ms Said said increased wait times were being seen across Australia, with even longer wait times out of the major capital cities.

Food allergies have shifted from being a fringe issue to a major public health concern. Picture: Shutterstock

A spokeswoman for Canberra Health Services said data on average wait times to see ACT-based immunologists was not collected.

"Immunologists also deal with patients with other conditions, including serious autoimmune and inflammatory diseases and immune deficiencies," the spokeswoman said.

"As a result, there is considerable demand for appointments. There are six immunologists employed by Canberra Health Services, all with part-time appointments."

Canberra immunologist Dr Raymond Mullins said while wait times vary from state to state, public hospital outpatient waiting lists are normally more than 12 months.

"Food allergies and anaphylaxis have moved from a marginal phenomena to an ongoing public health issue for an increasing proportion of the population and their caregivers," Dr Mullins said.

"This has implications in terms of cost of care, the need for medical visits and review, the use and availability of emergency medication such as EpiPens."

The availability of EpiPens is now a core health concern for public institutions. Picture: Shutterstock

While data from the ACT is not available, figures from Victoria showed a median waiting time of more than 100 days to access immunologists for allergy testing.

Dr Mullins said more people were in need of seeing immunologists as children who developed allergies got older.

"Young children who have nut allergies will generally still have persistent food allergy 80 per cent time," he said.

"That means we have an ageing population of teenagers and young adults with persistent food allergy at greater risk of having more serious reactions including fatalities."

Ms Said said as more adults were experiencing severe allergies, many immunology clinics have been unable to keep up with demand, with many clinics only specialising in paediatrics.

"There's only a handful of public clinics, and most are specifically for children, yet there's a growing number of adults with allergic diseases," she said.

"It's very concerning because allergic diseases can't be cured and it has to be managed, and people need to be educated on how it can be managed."

The access to treatment for those with anaphylaxis forms part of a federal government inquiry into severe allergies.

In its submission to the inquiry, the federal Health Department said Australia had one of the highest rates of allergies and anaphylaxis in the world.

"Available evidence from hospital admissions for anaphylaxis indicates the prevalence has increased in many western countries, including Australia," the department said.

"Total hospital admissions rates for all causes of anaphylaxis increased by 8 per cent each year between 1997 and 2013."

The Australian Society of Clinical Immunology and Allergy has told the inquiry the current access process for immunology testing was time-consuming and complicated, calling for access to be simplified.

Ms Said said more public clinics were needed in order to reduce wait times for those with anaphylaxis.

"We need them especially in rural and remote areas to allow for greater access to an accurate diagnosis and accurate information on allergy management," she said.

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Anaphylaxis patients forced to wait more than a year for testing - The Canberra Times

PhD Program | Immunology | Stanford Medicine

The Immunology doctoral program offers instruction and research opportunities leading to a Ph.D. in Immunology. Two tracks are offered:

The goal of the Ph.D. Program in Immunologyis to develop investigators who have a strong foundation in Immunology and related sciences in order to carry out innovative research. The program features a flexible choice of courses and seminars combined with extensive research training in the laboratories of participating Immunology faculty. Specifically, immunology graduate students:

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PhD Program | Immunology | Stanford Medicine

Current Research in Immunology – Journal – Elsevier

Current Research in Immunology (CRIMMU) is a new primary research journal, gold open access journal from Elsevier. CRIMMU publishes original papers and short communications that cover all aspects of molecular and cellular immunology.

Current Research in Immunology is a peer-reviewed gold open access...

Current Research in Immunology (CRIMMU) is a new primary research journal, gold open access journal from Elsevier. CRIMMU publishes original papers and short communications that cover all aspects of molecular and cellular immunology.

Current Research in Immunology is a peer-reviewed gold open access (OA) journal and upon acceptance all articles are permanently and freely available. It is a companion to the highly regarded review journal Current Opinion in Immunology (2018 CiteScore 7.080) and is part of the Current Opinion and Research (CO+RE) suite of journals. All CO+RE journals leverage the Current Opinion legacy-of editorial excellence, high-impact, and global reach-to ensure they are a widely read resource that is integral to scientists' workflow.

Current Research in Immunology topics covered include (but are not restricted to):

Topics which may be considered for the journal only if the following requirements are met:

Current Research in Immunology builds on Elsevier's reputation for excellence in scientific publishing and long-standing commitment to communicating reproducible biomedical research targeted at improving human health.

Ethics in Publishing: General Statement

The Editor(s) and Publisher of this Journal believe that there are fundamental principles underlying scholarly or professional publishing. For more information, please refer to: http://www.elsevier.com/conflictsofinterest

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Current Research in Immunology - Journal - Elsevier

Department of Immunology

UW holds No. 4 position on global rankings among US universities

The University of Washington again placed fourth among U.S. higher education institutions, according to the NTU Rankings. For the first time, UW Immunology placed fourth in the world among the subjects at the UW that ranked in the top ten worldwide. The NTU ranking is entirely based on scientific papers, reflecting scientific performance from three perspectives on research productivity, impact and excellence read more

The Department of Immunology is a basic science department within the University of Washington, School of Medicine located in Seattle.

Our mission is to advance understanding of the function of the immune system in order to enhance our ability to fight infectious disease, cancer and autoimmune disease. Basic research of all aspects of immunology is critical to this mission, as well as translational research to link our findings to the development of new therapies.

We hold diversity and inclusiveness as core values in our department and emphasize their importance throughout our research, education and practice. We strive to create a climate that fosters belonging, respect and value for all within our scientific community and the institution.

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Department of Immunology