Category Archives: Immunology

DR-MENON – Asthma, Allergy & Immunology Centre, Baton …

June 18, 2018 medical

AAIC is a patient centered practice.

We offer specialty consultation and comprehensive care of bronchial asthma, allergies, and primary immunodeficiency diseases (PIDDs) in children and adults. Our physicians are nationally recognized and board certified. They have expertise in immune evaluation (for patients with recurrent and severe infections), treatment of asthma, sinus disease, eczema, allergy to stinging insects, fire ant, latex, drug and food, eosinophilic esophagitis, hives and hereditary angioedema (HAE).

Services offered include skin testing with allergens, food, drugs and venoms and desensitization (immunotherapy), Patch Tests, Xolair (anti-IgE monoclonal antibody), intravenous or subcutaneous immunoglobulin infusions for PIDDs and C1INH infusions for HAE.

Their mission is to improve the patient's quality of life with individualized care, kindness, compassion, courtesy and respect. The doctors are known for serving the community through interaction, education, preventive medicine and outreach programs. They are peer nominated and selected as the Best Doctors in America.

At AAIC, we offer personalized medicine, at its best.

Monday through Thursday 8:00 AM till 7:00 PM

Immunology

Immunology | Immunology Conferences | Clinical Immunology …

June 18, 2018 student

Sessions & Tracks

#Track 1:Immunogenomics

Immunogenomics originally was framed by research supporting the hypothesis that cancer mutations generated novel peptides seen as non-self by the immune system. Neoantigens has been facilitated by the combination of specialized computational analyses, new sequencing technologies, and HLA binding predictions that evaluate somatic alterations in a cancer genome and interpret their ability to produce an immune-stimulatory peptide. The resulting information can characterize a tumors Neoantigens load, its cadre of infiltrating immune cell types, the T or B cell receptor repertoire, and direct the design of a personalized therapeutic.

RelatedImmunology Conferences|Immunologists Meetings|Immunology Events

9thMolecular Immunology Conferences,Immunogenetics Congress, March 08-09,2018,London, UK; 12thInternationalAllergy and Asthma Conferences,Clinical Immunology Conferences, Oct 1-2, 2018, Moscow, Russia; 22ndEdition of InternationalImmunology ConferencesandInfectious Diseases Conferences, May 10-11, 2018,Frankfurt, Germany; 3rdInternationalAutoimmunity Conferences, November 26-27, 2018, Dublin, Ireland;9thEuropean Immunology Conference, June 14-16, 2018,Rome, Italy; 15thInternationalImmunology Conferences2018, July 05-07, 2018,Vienna, Austria

#Track 2:Veterinary Immunology & Immunopathology

Veterinary immunology is the study of all features of the immune system in animals. It is a division of biomedical science and associated to zoology and veterinary sciences. It is engrossed in how the immune system works, how vaccines thwart disease and why vaccines occasionally do not work and cause antagonistic responses. Every living creatureisconstantly presented with substances that are not fit for theirupbringing. Most living beings secure themselves against such substances in more than one way with physical barriers, forexample, orwith chemicals that repulse or slaughter invaders. Creatures with spines, called vertebrates, have these sorts of generaldefensive instruments;however, they additionally have a more progressed defensive framework called the immune system. The invulnerable framework is aperplexing systemof organs containing cells that perceive outside substances in the body and devastate them. It secures vertebrates against pathogens, or irresistible specialists, for example, infections, microscopic organisms, growths, and different parasites. The human immune system is the most complex. Although there are numerous possibly unsafe pathogens, nopathogencan invade or attack all organisms because a pathogen's ability to cause harm requires asusceptible victim, and not all creatures are powerless to similar pathogens. For example, the infection that causes AIDS in people does notcontaminatecreatures, for example, dogs, cats, and mice. Correspondingly, people are not defenseless to the infections that cause canine distemper,cat leukemia, andmousepox.

RelatedImmunology Conferences|Immunologists Meetings|Immunology Events

15thInternationalImmunology Conferences2018, July 05-07, 2018,Vienna, Austria; 9thMolecular Immunology Conferences,Immunogenetics Congress, March 08-09,2018,London, UK; 12thInternationalAllergy and Asthma Conferences,Clinical Immunology Conferences, Oct 1-2, 2018, Moscow, Russia; 22ndEdition of InternationalImmunology ConferencesandInfectious Diseases Conferences, May 10-11, 2018,Frankfurt, Germany; 26thEuropean Neurology Congress, August 06-08, 2018,Madrid, Spain; 9thEuropean Immunology Conference, June 14-16, 2018,Rome, Italy

#Track 3: Vaccines & Immunotherapy

The vaccineis abiologicalpreparation that enhances resistance to specific infection. It contains particular operators thatlooklike an illness bringing about themicroorganismas well as animates body's safe framework to perceive the outside specialists.A vaccineis dead orinactivatedlife forms or refined items gotten from them. Entire creatureantibodiescleaned macromolecules as vaccines,recombinant antibodies, DNA antibodies. The insusceptible framework perceives vaccine specialists as remote, devastates them, and"recollects that"them.

Immunotherapy is a standout amongst the most energizing ranges ofnew disclosures and medicinesfor various sorts of atumor. Seeing how the insusceptible framework functionsareopening the ways togrownew medicines that are changing the way we consider and treat growth. The vast majority acceptingimmunotherapiesare dealt with in particular malignancy focuses and a large portion of them are selected inclinical trials. This may change as more trials are finished and more medications are affirmed by theFood and Drug Administration(FDA) to treat various types of malignancy.

RelatedImmunology Conferences|Immunologists Meetings|Immunology Events

Antibody Engineering Meetings, 9thEuropean Immunology Conferences, June 14-16, 2018,Rome, Italy; 9thMolecular Immunology Conferences,Immunogenetics Congress, March 08-09,2018,London, UK; 3rdInternationalAutoimmunity Conferences, November 26-27, 2018, Dublin, Ireland; 12thInternationalAllergy and Asthma Conferences,Clinical Immunology Conferences, Oct 1-2, 2018, Moscow, Russia; 15thInternationalImmunology Conferences2018, July 05-07, 2018,Vienna, Austria; 4thWorld Applied Microbiology Congress, November 29-December 01, 2017Madrid, Spain; 22ndEdition of InternationalImmunology ConferencesandInfectious Diseases Conferences, May 10-11, 2018,Frankfurt, Germany

#Track 4:Immunotoxicology & Molecular Biomarkers

Immunotoxicologyis the investigation of immune dysfunction resulting from exposure of an organism to a xenobiotic.Immunotoxicologyis moderately new interdisciplinary logical field concentrated on recognizable proof and investigation of the compoundand, in a more extensive sense, additionally physical and organic elements of nature which can bring about undesirable and normally accidentalimmunomodulation.The immune dysfunction may take the form ofimmunosuppression,sensitivity,autoimmunity, andincendiary based illnesses. Insusceptible System assumes a basic part in host imperviousness to sickness and additionally in typicalhomeostasisof a living being; recognizable proof ofimmunotoxichazard is huge in the assurance of human, creature and wildlife health. In addition, immunotoxicology likewise researches the properties of new immunotherapeutic pharmacological items arranged by means ofrecombinant DNA methods(interleukins,interferons,development variables, hostile toirritation drugs,neuroendocrine hormones,neuropeptideswith respect to theirimmunotoxic potentialand security of their utilization.

Abiomarkeris atrademarkthat can be unbiasedly measured as a marker of typical organic procedures, pathogenic procedures or apharmacological reactionto a restorative mediation. These are utilized for some reasons including malady conclusion and guess, forecast and appraisal oftreatment reaction. Biomarkers can be trademarknatural propertiesor particles that can be recognized and measured in parts of the body like the blood or tissue. They may show either ordinary or infectedprocedurein the body. Biomarkers can be particular cells, particles, orgenes, geneitems, catalysts, or hormones

RelatedImmunology Conferences|Immunologists Meetings|Immunology Events

#Track 5:Immunoresearch & Immunotechnology

Immunologyisworried aboutthe utilization ofimmunological responsesfor the determination, avoidance, and treatment of various infections. It is firmly identified with therapeutic and veterinary microbiology, the study of disease transmission, physiology andPathophysiology, organic chemistry, and endocrinology.Viral Immunologyand the immunology of parasitic infections are autonomous branches of commonsense immunology. Immunology concentrates theantigenic creationof microorganisms, attributes of thesafetyprocedures in different sorts of contaminations, andnonspecific types of Imperviousnessto the causative operators of irresistible infections. Investigation of the immunological procedures and the immunological reproduction of the living being created byNon-infectious Antigensof the exogenousand endogenous starting point and the advancement of strategies for controlling unfavorably susceptible sicknesses are winding up noticeably progressively imperative. Different branches of clinical immunology are likewise growing seriously. These incorporate radiation immunology, which concentrates the disturbance of immunological reactivity by illumination, andImmunohematology, which researches the antigenic piece of platelets and the causes and instrument of advancement of immunological harm to the circulatory framework. Immunology is creating techniques forImmunoprophylaxis,Immunotherapy, andImmunodiagnostics.

Immunologic Researchspeaks to an interesting medium for the introduction, translation, and elucidation of complex logical information. Data is displayed as interpretive combination surveys,unique researcharticles, symposia, publications, and hypothetical expositions. The extent of scope stretches out to cell immunology,immunogenetics,sub-atomic and auxiliary immunology,immunoregulation and autoimmunity,immunopathology,tumor immunology, have safeguard andmicrobial resistance, including viral immunology,immunohematology,mucosal invulnerability, supplement, transplantation immunology, clinical immunology, neuroimmunology,immunoendocrinology, immunotoxicology, translational immunology, and history of immunology.

RelatedImmunology Conferences|Immunologists Meetings|Immunology Events

#Track 6: Immunological Clinical Practices &Trials

RelatedImmunology Conferences|Immunologists Meetings|Immunology Events

AnImmunological Clinicaltrial is a unique research program designed to cultivate a collaborative environment that allows basic and translational immunologists to work side-by-side with clinicians.Clinical trial & Practicesare always designed to gain some knowledge about something not yet well-known or proven. A person may volunteer to participate in a clinical study. A physician may recommend a patient to consider volunteering forspecific study participation, as part of the patient therapeutic treatment options. Clinical trials are highly regulated and are conducted following strict scientific standards in order to protect patients and to produce meaningful results.

The clinical trial allows accelerating the bench-to-bedside transition of innovative immunotherapies, with much attention given to critical diseases which areknown to relapseor is refractive to conventional treatments currently available. Many of the novel immunotherapy approaches, which originated from basic science research by the clinical trial and practices, are now being explored as new treatment modalities in patients, with a significant number advancing through clinical trials towards FDA approval.

RelatedImmunology Conferences|Immunologists Meetings|Immunology Events

9thMolecular Immunology Conferences,Immunogenetics Congress, March 08-09,2018,London, UK; 3rdInternationalAutoimmunity Conferences, November 26-27, 2018, Dublin, Ireland; 15thInternationalImmunology Conferences2018, July 05-07, 2018,Vienna, Austria;Annual Immunology Conferences, Sep 13-14, 2018,Zurich, Switzerland; 9thEuropean Immunology Conferences, June 14-16, 2018,Rome, Italy; 12thInternationalAllergy and Asthma Conferences,Clinical Immunology Conferences, Oct 1-2, 2018, Moscow, Russia; 22ndEdition of InternationalImmunology ConferencesandInfectious Diseases Conferences, May 10-11, 2018,Frankfurt, Germany

#Track 7: Pediatrics Immunology

A child suffering from allergies or different issues with his insusceptible frameworkis eludedasPediatric Immunology. Childs immune system battles againstinfections.On the off chance that the child hashypersensitivities,their resistant framework wrongly responds to things that are normally innocuous. Pet dander, dust, tidy, form spores, bug stings, nourishment, and solutions are cases of such things. This response may make their body react tomedical issues, for example, asthma,roughage fever, hives,dermatitis(a rash), or an exceptionally extreme and unordinary response calledanaphylaxis. Once in a while, if your childs invulnerable framework is not working right, he may experience the ill effects of successive, serious, or potentiallyunprecedented diseases. Cases of such contaminations aresinusitis(aggravation of at least one of the sinuses),pneumonia(disease of the lung),thrush(a growth contamination in the mouth), andabscesses(accumulations of discharge encompassed by kindled tissue) that continue returning.

RelatedImmunology Conferences|Immunologists Meetings|Immunology Events

22ndEdition of InternationalImmunology ConferencesandInfectious Diseases Conferences, May 10-11, 2018,Frankfurt, Germany; 9thEuropean Immunology Conference, June 14-16, 2018,Rome, Italy; 12thInternationalAllergy and Asthma Conferences,Clinical Immunology Conferences, Oct 1-2, 2018, Moscow, Russia; 15thInternationalImmunology Conferences2018, July 05-07, 2018,Vienna, Austria; 9thMolecular Immunology Conferences,Immunogenetics Congress, March 08-09,2018,London, UK; 3rdInternationalAutoimmunity Conferences, November 26-27, 2018, Dublin, Ireland

#Track 8: Immunosenescence

A decline in immune competence is well recognized in the elderly. Aged people show a decline in many aspects of protective immunity including a tendency to producelower-affinity antibodies, a failure to generate long-lasting immunity to vaccination and a loss ofdelayed-type hypersensitivityto antigens previously encountered in life. Bacterial and viral diseases such as tuberculosis and herpes zoster (shingles), respectively, are found much more frequently in the elderly compared to young adults.Septicemia(infectious microbes in the bloodstream) is also more common in the elderly. Pneumonia is more prevalent and more often fatal and other viral and bacterial infections are more common in older people leading to an increase in morbidity and mortality. This decline inimmune competenceis not solely a result of a defective immune system, as it is also a result of changes in the endocrine and nervous systems, as well as nutritional and other factors including the general state of health of the older individual.

Malignancies are seen much more frequently in older people and while many of these may be related toinappropriate DNA translational events, a defective immune system may also be responsible since there is an association between immune deficiency and increased malignancy. Defects in all compartments of the immune system have been reported in the elderly. While studies are often contradictory, reliable data indicate that defects develop inT and B cell immunityas well as in the phagocytic component of immunity. Increased NK cell numbers and decreased T cell function is also a feature of aging.IL-6 and IL-10production by monocytes is increased with aging as well as the pro-inflammatory cytokines IL-1 and TNF. MHC molecules are expressed at a lower density on a variety of cells and fewer T cells expressing CD28, important for T cell signaling, are found in the elderly. Antibody responses are usually of lower affinity andautoantibodiesare found much more frequently. Hemopoiesis is impaired with fewer progenitor cells produced.Thymic involutionis well established in the elderly with fewer T cells entering the vascular pool and hence secondary lymphoid organs.AICD and apoptosisare increased. Age-related changes in hormonal and neurotransmitter function may also have an impact on immune function and may determinemorbidity, mortality, and longevity.

RelatedImmunology Conferences|Immunologists Meetings|Immunology Events

3rdInternationalAutoimmunity Conferences, November 26-27, 2018, Dublin, Ireland, 15thInternationalImmunology Conferences2018, July 05-07, 2018,Vienna, Austria; Annual Immunology Conferences, Sep 13-14, 2018,Zurich, Switzerland; 9thEuropean Immunology Conferences, June 14-16, 2018,Rome, Italy; 9thMolecular Immunology Conferences,Immunogenetics Congress, March 08-09,2018,London, UK; 9thEuropean Immunology Conference, June 14-16, 2018,Rome, Italy, 12thInternationalAllergy and Asthma Conferences,Clinical Immunology Conferences, Oct 1-2, 2018, Moscow, Russia; 22ndEdition of InternationalImmunology ConferencesandInfectious Diseases Conferences, May 10-11, 2018,Frankfurt, Germany

#Track 9: Cancer & Tumor Immunology

The immune system is the body'sinitialline of barrier against most illnesses andirresistible intruders. Seeing how the immune system functionsor does not workagainst growth is an essential concentration of theCancer ImmunologyProgram. Specialists are decoding the fundamental science of safe reactions with the objective of growing newsafe treatment approachesand enhancing existing ones.The Hugeconcentrate is on consolidated methodologies that expand upon disclosures inmalignancyhereditary qualities (changes to DNA),epigenetics(concoction modifications to the earth of DNA) andimmunology. Late revelations utilize new discoveries about how the immune system capacities to make collaboration and enhance the viability of surgery, disease antibodies, medicate treatments and radiation treatment. Accuracy, or customized, medication is utilized to control the best invulnerable ways to deal with the correct patients, and this energizing work is promptingdependable reactionsin numerous growths. Eventually, scientists hope to unravel why insusceptible treatments work for a few patients and not others, enrolling the body's own particular safeguards against for all intents and purposes each sort of growth.

RelatedImmunology Conferences|Immunologists Meetings|Immunology Events

#Track 10:Allergies & Hypersensitivity

Allergies represent TYPE I responses as per the Gell and Coombs grouping. Most are brought about by IgEANTIBODIESwhich are fit for the official toFc-receptorsfor IgE on tissueMAST CELLS. Cross-connecting of these layers bound IgE's by particular antigen brings about pole cellDEGRANULATION; this procedure dischargesHISTAMINEand an assortment of other effector molecules, which thus brings about the bunch side effects of sensitivity. (rash, feed fever, asthma and so on.)Passive cutaneous hypersensitivity(PCA) in the guinea pig and thePrausnitz-Kstner (P-K) skin responsein people give models to understanding the basic component of unfavorably susceptible responses. Administration of sensitivities starts with allergen shirking and incorporates the utilization of an assortment of medications and allergen-particularDESENSITIZATION.

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#Track 11:Clinical Immunology: Current & Future Trends

Clinical Immunology has developed in the course of recent decades from atranscendent research centerbase to a joined clinical and lab claim to fame. Theclinical workof Immunologists is to a great extent out-patient based and includes essentialimmunodeficiency, hypersensitivity, immune system rheumatic ailment and systemic vasculitis (mutually with Rheumatologists), joint pediatric centers for kids withimmunodeficiency and sensitivityandimmunoglobulinimbuement facilities for patients with immunizer lack. On the research center front,Consultant Immunologistsare in charge of coordinating demonstrative immunology benefits and play out an extensive variety of obligations including clinical contact, elucidation and approval of results,quality confirmation and test improvement.

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#Track 12 : Lymph-proliferative Disorders

Lymphoproliferativedisorders are an arrangement of scatters described by the abnormal proliferation of lymphocytes into amonoclonal lymphocytosis. The two noteworthy sorts of lymphocytes are B cells and T cells, which are gotten from pluripotenthematopoietic foundational microorganismsin the bone marrow. People who have some kind of brokenness with their immune system are powerless to build up a lymphoproliferative disorder since when any of the various control purposes of theresistant frameworkend up noticeably useless, immunodeficiency orderegulationof lymphocytes will probably happen. There are a few acquired quality transformations that have been distinguished to bring aboutlymphoproliferative disorder; in any case, there are additionally gained and iatrogenic causes.

RelatedImmunology Conferences|Immunologists Meetings|Immunology Events

#Track 13:Immunodermatology

Immunodermatologythinks about skin as an organ ofinsusceptibilityin wellbeing and malady. A few territories have extraordinary consideration, for example, photograph immunology (impacts of UV light on skin guard), incendiary illnesses, for example, Hidradenitis suppurativa, unfavorably susceptible contact dermatitis and atopic dermatitis, probably immune system skin ailments, for example,vitiligo and psoriasis, lastly the immunology of microbial skin ailments, for example, retrovirus contaminations and sickness. New treatments being developed for theimmunomodulationof basic immunological skin sicknesses incorporate biologicals gone for killing TNF-alfa andchemokine receptor inhibitors.

RelatedImmunology Conferences|Immunologists Meetings|Immunology Events

15thInternationalImmunology Conferences2018, July 05-07, 2018,Vienna, Austria; 9thMolecular Immunology Conferences,Immunogenetics Congress, March 08-09,2018,London, UK; 9thEuropean Immunology Conference, June 14-16, 2018,Rome, Italy; 12thInternationalAllergy and Asthma Conferences,Clinical Immunology Conferences, Oct 1-2, 2018, Moscow, Russia; 22ndEdition of InternationalImmunology ConferencesandInfectious Diseases Conferences, May 10-11, 2018,Frankfurt, Germany; 3rdInternationalAutoimmunity Conferences, November 26-27, 2018, Dublin, Ireland

#Track 14:Immunohematology

Immunohematologyis the study of the immunology and genetics of blood cell antigens, blood groups and specific blood proteins(such as complement) and antibodies esp. important in blood banking and transfusion medicine.

Immunohematology is more commonly known as "blood banking" or blood biology.

This is the field of laboratory medicine dealing with preparing blood components and blood for transfusion as well a theselection of compatible and appropriate components for transfusion. Individuals may become immunized to red blood cells due to previous exposure to red blood cells(RBCs) of other people, most commonly throughtransfusion or pregnancy. Our children basically receive immunizations which leads to form antibodies against theimmunizing material,such as tetanus. If they are again exposed to the organism which causes tetanus, the antibodies will destroy them before they can cause infection. In a similar way, red blood cells have specific structures on their surface calledantigens. If an individual is pregnant with a fetus or transfused with blood that possesses structures which the recipient or mother does not have, this may induce the individual to form antibodies. These antibodies may then destroy red blood cells(RBCs) which possess the antigen if additional sessions of transfusions are needed. That is why all blood banks will "screen" potential blood recipients forunexpected antibodiesand they will then select blood which lacks the offending antigen. The formation of these antibodies is an unusual occurrence, occurring in approximately 0.1-3

RelatedImmunology Conferences|Immunologists Meetings|Immunology Events

#Track 15:Humoral & Cellular Immunology

Our immune system distinguishes two categories of foreign substances. One category consists ofantigens (foreign substances)that are freely circulating in the body. These include molecules, viruses, and foreign cells. The Second Category consists of self-cells that displayaberrant MHC(Major Histocompatibility Complex) proteins. These aberrant MHC proteins can originate from antigens that have been engulfed and broken down (exogenous antigens) or from tumor cells andvirusinfectedthat are actively synthesizing foreign proteins (endogenous antigens).

Depending on the kind of foreign invasion, two different immune responses occur:

The Humoral Immunology orHumoral response(or antibodymediated response) involves B cells that pathogens or recognize antigens that are circulating in the lymph or blood (humor is a medieval term for body fluid). In this, the antigens bind to B cells which lead to Interleukins or helper T cells stimulate B cells.

The Cellular Immunology orCellmediated responseinvolves mostly T-cells and responds to any cell that displays aberrant MHC markers, including cells invaded by pathogens, tumor cells, or transplanted cells.Self-cells or Antigen Presenting Cells(APCs) displaying foreign antigens bind to T cells.

RelatedImmunology Conferences|Immunologists Meetings|Immunology Events

9thMolecular Immunology Conferences,Immunogenetics Congress, March 08-09,2018,London, UK; 12thInternationalAllergy and Asthma Conferences,Clinical Immunology Conferences, Oct 1-2, 2018, Moscow, Russia; 3rdInternationalAutoimmunity Conferences, November 26-27, 2018, Dublin, Ireland; 15thInternationalImmunology Conferences2018, July 05-07, 2018,Vienna, Austria; 9thEuropean Immunology Conference, June 14-16, 2018,Rome, Italy; 22ndEdition of InternationalImmunology ConferencesandInfectious Diseases Conferences, May 10-11, 2018,Frankfurt, Germany; 2ndClinical Oncology Conferences, Molecular Diagnostics Conferences, June 11-13, 2018, Dublin, Ireland

#Track 16:Neuroimmunology

The investigation of the connection betweenour centralnervous system(the brain and spinal string) and our immune system. Neuroimmunology adds to the advancementof newpharmacological medicationsfor a few neurological conditions. The immune system and the sensory system keep up broad correspondence, including "hardwiring" of thoughtful and parasympathetic nerves to lymphoid organs.Neurotransmitters, for example, acetylcholine, norepinephrine, vasoactive intestinal peptide, substanceP, and histamine adjust the insusceptibleaction.Neuroendocrine hormones, for example,corticotrophin-discharging element,leptin, and alpha-melanocyte empowering hormone manage cytokine adjust. The immune system adjusts brain action, including body temperature, rest and bolstering conducts. Particles, for example, the significant histocompatibility complex not just direct T cells to immunogenic molecules held in its separated additionally regulate improvement of neuronal associations. Neurobiologists and immunologists areinvestigatingnormal thoughts like the neurotransmitter to comprehend properties.

RelatedImmunology Conferences|Immunologists Meetings|Immunology Events

9thMolecular Immunology Conferences,Immunogenetics Congress, March 08-09,2018,London, UK; 12thInternationalAllergy and Asthma Conferences,Clinical Immunology Conferences, Oct 1-2, 2018, Moscow, Russia; 3rdInternationalAutoimmunity Conferences, November 26-27, 2018, Dublin, Ireland; 15thInternationalImmunology Conferences2018, July 05-07, 2018,Vienna, Austria; 9thEuropean Immunology Conference, June 14-16, 2018,Rome, Italy; 22ndEdition of InternationalImmunology ConferencesandInfectious Diseases Conferences, May 10-11, 2018,Frankfurt, Germany; 2ndClinical Oncology Conferences, Molecular Diagnostics Conferences, June 11-13, 2018, Dublin, Ireland

#Track 17:Mucosal Immunology

Themucosal surfacesof the body have a higher danger of contamination because of their cooperative energy with the outside condition.Mucosal immunologyraises those parts of the resistant framework that shield the body from contamination. It gives threemain functionssecures themucous film against disease, keeping the take-up of antigens,microorganisms, and other outside materials, and directing the creature's insusceptible reaction to that material. The mucosalinsusceptible frameworkis containedmechanical (bodily fluid), concoction and cell elements.

RelatedImmunology Conferences|Immunologists Meetings|Immunology Events

9thMolecular Immunology Conferences,Immunogenetics Congress, March 08-09,2018,London, UK; 12thInternationalAllergy and Asthma Conferences,Clinical Immunology Conferences, Oct 1-2, 2018, Moscow, Russia; 3rdInternationalAutoimmunity Conferences, November 26-27, 2018, Dublin, Ireland; 15thInternationalImmunology Conferences2018, July 05-07, 2018,Vienna, Austria; 9thEuropean Immunology Conference, June 14-16, 2018,Rome, Italy; 22ndEdition of InternationalImmunology ConferencesandInfectious Diseases Conferences, May 10-11, 2018,Frankfurt, Germany; 2ndClinical Oncology Conferences, Molecular Diagnostics Conferences, June 11-13, 2018, Dublin, Ireland

#Track 18:Autoimmune & Inflammatory Diseases

The immune system has the capacity to mount animmune responseto virtually all molecules and/or cells. Although the capacity to respond to self-antigen is present in all of us, in most instances such responses result in tolerance, indicating that mechanisms must exist to prevent orsubdue autoimmune responses. Moreover, auto-reactiveT and B cells, as well asautoantibodies, are found in people who do not have autoimmune diseases, demonstrating that immunological auto-reactivity alone is not sufficient for the development of the disease. The mechanisms currently thought to prevent/dampen autoimmune responses include inactivation or deletion ofautoreactive B and T cells, active suppression by cells or cytokines, idiotype or anti-idiotype interactions, and the immunosuppressive adrenal hormones, the glucocorticoids. When dampening mechanisms fail or are overridden, a response directed against self-antigen can occur, resulting inautoimmune diseasesthat range from those which areorgan-specific(diabetes and thyroiditis) to those which are systemic (non-organ specific) such assystemic lupus erythematosusandrheumatoid arthritis.

RelatedImmunology Conferences|Immunologists Meetings|Immunology Events

3rdInternationalAutoimmunity Conferences, November 26-27, 2018, Dublin, Ireland; 15thInternationalImmunology Conferences2018, July 05-07, 2018,Vienna, Austria; 9thEuropean Immunology Conference, June 14-16, 2018,Rome, Italy; 12thInternationalAllergy and Asthma Conferences,Clinical Immunology Conferences, Oct 1-2, 2018, Moscow, Russia; 22ndEdition of InternationalImmunology ConferencesandInfectious Diseases Conferences, May 10-11, 2018,Frankfurt, Germany; 9thMolecular Immunology Conferences,Immunogenetics Congress, March 08-09,2018,London, UK

Continued here:
Immunology | Immunology Conferences | Clinical Immunology ...

Immunology

Immunology and Serology | Johns Hopkins Medicine Health …

September 26, 2017 medical

What are immunology and serology?

Immunology is the study of the body's immune system and its functions and disorders. Serology is the study of blood serum (the clear fluid that separates when blood clots).

Immunology and serology laboratories focus on the following:

Identifying antibodies. These are proteins made by a type of white blood cell in response to a foreign substance (antigen) in the body.

Investigating problems with the immune system. These include when the body's immune system attacks its own tissues (autoimmune diseases) and when a body's immune system is underactive (immunodeficiency disorders).

Determining organ,tissue, and fluidcompatibility for transplantation

Test

Uses

Immunoglobulins

These are proteins in the body that have antibody activity.Excessive amounts of these proteinsmay be caused by a variety of conditions including infection, autoimmune disorders, cancers, and chronic diseases. A lack of these proteins may be caused by many conditions including cancers, medicines, and chronic diseases

Rheumatoid factor

Used tohelp classify arthritis and diagnose rheumatoid arthritis. Other tests are often used as well to classify and determine types of arthritis.

HLA (human leukocyte antigens) typing

Tested todetermine compatibility in organ, tissue, and bone marrowtransplantation. Also tested to determine paternity, and to diagnose HLA-related disorders such as certain autoimmune conditions.

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Immunology and Serology | Johns Hopkins Medicine Health ...

Immunology

Immunology Department | MD Anderson Cancer Center

September 26, 2017 medical

Immunology is the study of biological systems used to defend the body against microbial pathogens such as bacteria, viruses, parasites and fungi. Evolution over the past several million years has equipped the immune system with a set of pattern recognition receptors, including the Toll-like receptors (TLRs), to distinguish self from microbial pathogens.

The innate immune response, a first line of defense, is initiated by signaling through the TLRs, by bacteria DNA, lipoproteins and polysaccharides, as well as viral RNA. Triggering TLRs activates antigen presenting cells (APCs) to upregulate costimulatory molecules and secrete cytokines, which allow these APCs to initiate immune responses.

The other arm of the immune system is the adaptive immune response, which uses antigen-specific receptors called antibodies and T-cell receptors (TCRs), found on B cells and T cells, respectively. These specific receptors drive highly efficient immunological responses that possess memory.

Please view our Research page to learn more about the exciting research taking place in the Immunology department.

The goal of MDAnderson's Immunology department is to perform multidisciplinary research and educational activities in basic and cancer immunology.

The new Center for Cancer Immunology Research (CCIR) is one of the six collaborative programs in biomedical research that make up the McCombs Institute for the Early Detection and Treatment of Cancer. The CCIR state-of-the-art facility for immunology research provides a platform for integrating basic and clinical immunology research programs.

Additionally, the Center for Inflammation and Cancer is one of several interdisciplinary research centers in the MD Anderson Institute for Basic Science, with the goal to provide an interactive platform across MD Anderson and the Texas Medical Center to study cross-regulation of inflammatory cell types and tumor microenvironments and the underlying molecular mechanisms using both animal models and patient samples.

Through our commitment to research and education, we hope to train future generations of high-caliber immunologists, as well as to advance knowledge of cancer, the immune system and how to direct the immune system toward eradicating cancer.

Physical addressSouth Campus Research Building I (SCRB I)7455 Fannin St.Houston, Texas 77030Telephone: 713-563-3203Fax: 713-563-3275

Mailing addressThe University of Texas MDAnderson Cancer CenterImmunology Department, Unit 901P.O. Box 1301402Houston, TX 77030-1903

Interested in learning more about immunotherapy clinicaltrials? Please call 1-855-873-4321 to schedule an appointment.

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Immunology Department | MD Anderson Cancer Center

Immunology

Award-winning immunologist Catherine Bollard to lead Center for Cancer and Immunology Research at the Children’s … – Markets Insider

September 7, 2017 student

WASHINGTON, Sept. 5, 2017 /PRNewswire-USNewswire/ --Children's National Health System announced that Catherine "Cath" Bollard, M.D., M.B.Ch.B., currently chief of the division of allergy and immunology, has been chosen to serve as director of the Children's Research Institute's (CRI) Center for Cancer and Immunology Research (CCIR).CCIR, with annual National Institutes of Health and other external funding of more than $10 million, includes more than 50 clinicians and scientists performing groundbreaking clinical and translational research in understanding the origins and developing and testing novel therapies for childhood cancers and immunologic disorders. In her new role, Dr. Bollard will lead the promotion and oversight of cancer and immunology research performed at Children's National and will join the leadership team of CRI.

"I'm honored and excited to take on this new role," says Dr. Bollard. "Since joining Children's National, we've made incredible progress in the cancer immunotherapy field. I look forward to continuing to build on these successes and lead the way toward the next generation of innovative immunotherapy treatments."

Since 2015, Dr. Bollard has served as the chief of the Division of Allergy and Immunology at Children's National after joining the hospital in 2013 to direct the cellular immunotherapy research program. She also is Professor of Pediatrics and of Microbiology, Immunology and Tropical Medicine at The George Washington School of Medicine and Health Sciences and serves as the director of the Program for Cell Enhancement and Technologies for Immunotherapy.

"Cath's unique background and pioneering work in T-cell immunotherapy have established her as an international leader in research and treatment of children with cancer and immunologic disorders," says Vittorio Gallo, Ph.D., Chief Research Officer at CRI. "Her leadership will reinforce our ongoing commitment to fighting cancer and developing innovative treatments."

Dr. Bollard's research focuses on improving outcomes for patients after hematopoietic stem cell transplantation, as well as the development of novel cell therapies for viral diseases and hematologic malignancies. With her move to Children's National, she and her team extended this focus to include pediatric solid tumors, human immunodeficiency virus, primary immune deficiency and more recently, allergic and autoimmune disorders.The novel cell therapies program that Dr. Bollard and her team built moves basic proof-of-principle work in the laboratory to the clinic.

"All of Children's National's progress in cellular immunotherapy can be attributed to Catherine and her leadership," says Mark L. Batshaw, M.D., Chief Academic Officer and Director of CRI. "We are confident her impact will extend even further in her new role."

An internationally recognized pioneer in cellular therapy, Dr. Bollard's publication record includes over 110 original papers, over 70 reviews and commentaries and 18 book chapters. She is a member of the American Society for Clinical Investigation and is President of the International Society for Cellular Therapy. Dr. Bollard serves as an associate editor for the journals Blood and Cytotherapy, a member of the National Cancer Institute Clinical Oncology Study Section and a member of the Cellular, Tissues and Gene Therapies Advisory Committee for the Food and Drug Administration, among other distinguished positions.

A New Zealand native, Dr. Bollard received her medical degree at University of Otago in Dunedin, New Zealand. Board Certified both in pediatrics and hematology, she worked both in New Zealand and London before moving to Baylor College of Medicine in Houston in 2000, where she completed her training and rapidly rose to Professor of Pediatrics, Medicine and Immunology and Director of the Texas Children's Cancer and Hematology Center Pediatric Lymphoma Program.

About Children's National Health System

Children's National Health System, based in Washington, D.C., has been serving the nation's children since 1870. Children's National is #1 for babies and ranked in every specialty evaluated by U.S. News & World Report including placement in the top 10 for:Cancer(#7),NeurologyandNeurosurgery(#9)Orthopedics(#9) andNephrology(#10). Children's National has been designated two times as a Magnet hospital, a designation given to hospitals that demonstrate the highest standards of nursing and patient care delivery. This pediatric academic health system offers expert care through a convenient, community-based primary care network and specialty outpatient centers. Home to the Children's Research Institute and the Sheikh Zayed Institute for Pediatric Surgical Innovation, Children's National is one of the nation's top NIH-funded pediatric institutions. Children's National is recognized for its expertise and innovation in pediatric care and as a strong voice for children through advocacy at the local, regional and national levels. For more information, visitChildrensNational.org, or follow us onFacebookandTwitter.

View original content with multimedia:http://www.prnewswire.com/news-releases/award-winning-immunologist-catherine-bollard-to-lead-center-for-cancer-and-immunology-research-at-the-childrens-research-institute-childrens-national-health-system-300514124.html

SOURCE Children's National Health System

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Award-winning immunologist Catherine Bollard to lead Center for Cancer and Immunology Research at the Children's ... - Markets Insider

Immunology

Moffitt cancer center trying to partner with researchers in Cuba – Tampabay.com

September 7, 2017 medical

TAMPA People who are working in Tampa and Havana on the fight against cancer say they have a lot to learn from one another.

And now, with relations between their two countries expanding if still tentative, they're ready to formalize a partnership.

For the last 18 months, cooperation has occurred below the radar for Tampa's H. Lee Moffitt Cancer Center & Research Institute and two centers in Cuba the National Institute of Oncology and Radiobiology and the Center of Molecular Immunology.

Surgeons from Cuba have visited Moffitt to study its treatment for pediatric bone cancer and Moffitt researchers have travelled to Cuba to learn how cancer scientists there break new ground with limited resources.

Against a politically divisive backdrop, with Florida interests including Gov. Rick Scott criticizing the Obama-era outreach to Cuba, Moffitt has declined to talk about its work with Cuba.

Now, officials at the Tampa center acknowledge they drafted a memorandum of understanding with their Cuban counterparts and it was submitted to the Cuban government a year ago. They still await a decision patiently, they say.

"The memorandum broadly describes that we want to collaborate on research and education," said David de La Parte, Moffitt executive vice president. "Once approved we can have a more intensive discussion around what we might do ... to benefit patients around the world and to advance science."

The Florida Aquarium in Tampa also pursued joint research with Havana's National Aquarium and waited two years for Cuban government approval.

An estimated 24 staffers from Tampa and Havana have been involved in visits as part of the Moffitt effort, de La Parte said.

On some occasions, they attended conferences together. Other times, doctors have shadowed their counterparts.

That a nation like Cuba with a struggling economy has anything to offer top researchers in the United States might come as a surprise, de La Parte said.

In fact, Cuba has much to offer, he said in part because of its underdog status.

Most notably, the Center of Molecular Immunology developed CIMAvax, a vaccine that extends and improves the quality of life for those with advanced lung cancer.

Gail Reed, editor of MEDICC Review, a journal dedicated to publishing Cuban scientists, said the Havana center has also developed treatments for brain cancer in children and for cancer in the pancreas, head and neck.

"Necessity is the mother of invention," Reed said. "Cuban leaders saw that without abundant natural resources or stable agricultural prices, investing in science and scientists was key to securing the population's health."

CIMAvax is undergoing clinical trials in the United States through the Roswell Park Cancer Institute in Buffalo, N.Y.

"Roswell Park were quicker on their feet than we were and it frankly agitated some of us," Moffitt's de La Parte said. "Here is this cancer center in New York that has a relationship with a country in our back yard."

Roswell began pursuing a partnership with the Center of Molecular Immunology in 2011 and made it official in April 2015.

Moffitt representatives didn't visit Cuba until May 2015, after executive orders from the Obama administration made scientific collaboration between the former Cold War adversaries easier to pursue.

Still, the state of Florida isn't on board with expanded cooperation involving Cuba. Opposition nationwide is at its strongest in South Florida, home to many who lost property and businesses nationalized by Cuba's Communist government.

Gov. Scott has stopped the state's ports from signing memorandums with Cuba by threatening to withhold state money.

And Moffitt relies heavily on state funding $7.1 million worth from two grant programs last year alone. So does the Florida Aquarium, which received $1 million from the state last year.

Partnering with Cuba could prove divisive, de La Parte admits, but he believes the medical and scientific benefits outweigh political considerations.

"We are not going to proceed in a way that will violate any kind of regulations," he said.

"Hopefully this is something that can be celebrated by our supporters, and the governor is one of our supporters."

Contact Paul Guzzo at pguzzo@tampabay.com. Follow @PGuzzoTimes.

Moffitt cancer center trying to partner with researchers in Cuba 09/07/17 [Last modified: Thursday, September 7, 2017 10:42am] Photo reprints | Article reprints

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Moffitt cancer center trying to partner with researchers in Cuba - Tampabay.com

Immunology

An immune clock of human pregnancy – Science (subscription)

September 2, 2017 student

Nima Aghaeepour

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94121, USA.

Edward A. Ganio

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94121, USA.

David Mcilwain

Department of Microbiology and Immunology, Stanford University, Stanford, CA 94121, USA.

Amy S. Tsai

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94121, USA.

Martha Tingle

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94121, USA.

Sofie Van Gassen

Department of Information Technology, Ghent University, and the Center for Inflammation Research, Ghent, Belgium.

Dyani K. Gaudilliere

Department of Surgery, Stanford University School of Medicine, Stanford, CA 94121, USA.

Quentin Baca

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94121, USA.

Leslie McNeil

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94121, USA.

Robin Okada

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94121, USA.

Mohammad S. Ghaemi

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94121, USA.

David Furman

Institute for Immunity, Transplantation and Infection, Stanford University School of Medicine, Stanford, CA 94305, USA.Institute for Immunogenetics, Jose de San Martin Clinical Hospital, National Scientific and Technical Research Council (CONICET), Buenos Aires, Argentina.

Ronald J. Wong

Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94121, USA.

Virginia D. Winn

Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94121, USA.

Maurice L. Druzin

Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94121, USA.

Yaser Y. El-Sayed

Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94121, USA.

Cecele Quaintance

Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94121, USA.

Ronald Gibbs

Department of Obstetrics and Gynecology, Stanford University School of Medicine, Stanford, CA 94121, USA.

Gary L. Darmstadt

Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94121, USA.

Gary M. Shaw

Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94121, USA.

David K. Stevenson

Department of Pediatrics, Stanford University School of Medicine, Stanford, CA 94121, USA.

Robert Tibshirani

Departments of Biomedical Data Sciences and Statistics, Stanford University, Stanford, CA 94121, USA.

Garry P. Nolan

Department of Microbiology and Immunology, Stanford University, Stanford, CA 94121, USA.

David B. Lewis

Division of Pediatric Immunology and Allergy, Stanford University School of Medicine, Stanford, CA 94121, USA.

Martin S. Angst

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94121, USA.

Brice Gaudilliere

Department of Anesthesiology, Perioperative and Pain Medicine, Stanford University School of Medicine, Stanford, CA 94121, USA.

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An immune clock of human pregnancy - Science (subscription)

Immunology

Immunology professor tangos between science and ballroom dancing – IU Newsroom

August 30, 2017 medical

View print quality imageImmunology professor Alexander Dent poses with ballroom dance instructor Lollie Henshilwood at the Arthur Murray Dance Studio in Avon.Photo by Tim Brouk, IU Communications

When he's not making CD4 regulatory and follicular helper T cells dance under the microscope, Alexander L. Dent does some moving himself.

The professor of immunology and microbiology at Indiana University-Purdue University Indianapolis has been pursuing a passion for ballroom dancing for the past five years. He has been a student at the Avon location of Arthur Murray Dance Studio and has performed around Indiana. From swing to tango, Dent has danced them all.

"It's a wild ride," said Dent before a recent rehearsal in Avon. "It's better than anything you can do at an amusement park, I think. Once you have a routine and you can run through it, it's super-fun. It's a lot of adrenaline."

Dent first laced up his dance shoes after shepherding then-9-year-old daughter, Anjani, to her own ballroom dance lessons. It looked like fun, so he gave ballroom a go. Wife Lakshmi joined in, and now the family rehearses together and has performed together in showcases.

Description of the following video:

Video transcript

IUPUI Professor is the king of swing, immunology and microbiology video onhttps://www.youtube.com/watch?v=8z7dd7Uz-Yc

[Words appear: IUPUI presents]

[Video: Alexander Dent dances with instructor]

[Alexander Dent speaks:It's just something I never really did before. I never really appreciated dance before, but once I started doing it, I liked it a lot. It's a good brain activity as well as reasonably good activity and there's studies that say it's good for you and that sort of thing.]

[It's neat, because it's better than anything that you could do at an amusement park, I think. Once you have a routine and you can run through it, it's just super fun to go through the whole thing. It's just a great ride and just a lot of adrenaline. Once you get into the more advanced dance, there's a lot of technique and a lot of careful things you have to think about.]

[I'm not naturally very, physically talented or anything like that. I'm a little clumsy, I guess, so it's probably harder for me to learn this than other people but I think it's still really good, and I feel like I've grown into it.]

[Words appear: IUPUI Fulfilling the Promise]

[End of transcript]

In his immunology lab nestled in the Indiana University School of Medicine's R2 Research building, Dent is in charge of School of Science graduate students as he pursues research to help humans resist disease and allergies. He also instructs America's future physicians in immunology classes at the medical school.

With ballroom dance, he was reminded that learning never stops. There is always the next level to attain, whether it's science or salsa dancing.

"It's a good combination of exercise and mental activity," Dent said. "I never appreciated dance before, but once I started doing it, I liked it a lot. A routine goes by in a second. I don't think I even take a breath the whole time."

Dent's work with regulatory T cells, which modulate the immune system while maintaining tolerance to self-antigens in hopes of preventing autoimmune or inflammatory disease, has been growing since his arrival to Indianapolis in 1998. His research looks to understand and eventually improve the responses of lymphocytes that help produce antibodies. His research on follicular helper cells, which are found in the spleen and lymph nodes and protect us from germs, aims to better control cellular response. His work can lead to better vaccines, and one ultimate goal is developing an effective HIV vaccine.

Testing on mice, Dent developed a model for transcription factor BCL6, which is critical for both Tfh cell differentiation and the differentiation of germinal center B cells and antibody-secreting plasma cells. The mouse model has been distributed worldwide and helps guide other immunologists as they dig into work with T cells.

Utilizing the training he received in the University of California system, Dent's current research digs deeper into finding ways to make our immune system stronger. His work also explores tumorigenesis via the BCL6 gene, which can initiate the cancer process when it is mutated.

"It's a very complicated factor in terms of it not having a straightforward pathway to how it's regulated and how it acts," Dent explained. "It turns off genes rather than turning them on, so that makes things a little trickier to look at. But we've found that it's a really important regulator that actually represses inflammatory genes."

Dent never claimed to be a natural ballroom dancer, but his love for music -- as a classically trained pianist and devourer of tunes, from heavy metal to jazz -- helped pique his interest in the activity. But most importantly, he saw the fun that young Anjani was having at her lessons, and he recognized dance's physical and mental positives. It also helped strengthen the family bond. When the Dents showed up for a recent rehearsal at Arthur Murray, the studio's staff lit up. The Dent family has become a staple in Avon.

"He has progressed so much," said Lollie Henshilwood, an Arthur Murray instructor who has worked with Dent for the past four years. "He's one of my favorite students to teach because he is so creative. There are so many different layers to him."

Henshilwood agreed that there is a science to ballroom dance.

"We could all just get out there and flop like fish, or instead, you can learn how your body moves," she explained. "You can learn from the feet up. It is a science, and he's almost mastered it. I'm very proud of him."

Back in the lab, Markus Xie, one of Dent's Ph.D. students, was familiar with his professor's dance pursuits almost as much as his breakthroughs in T cell research.

"I think outside activities help us relax," said Xie, an avid golfer. "Sometimes we also relax in the lab, but it's better to get some balance in life."

That balance has helped Xie take Dent's foundational work and apply it to some "very promising" food allergy research, namely how and why some humans suffer from peanut allergies. Xie said the work can have some future ramifications for food allergy sufferers.

While Dent doesn't plan on turning into a professional ballroom dancer, he does find the new hobby helpful. The cellular research he choreographs actually gets a boost from his artistic side.

"Once you get into the more advanced dancing, there's a lot of technique and lot of careful things you have to think about," he said. "I feel like I've grown into it."

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Immunology professor tangos between science and ballroom dancing - IU Newsroom

Immunology

UPMC Hillman Cancer Center immunology expert available to talk about FDA approval of CAR – T cell therapy. – Newswise (press release)

August 30, 2017 medical

Newswise The FDA today approved the first ever CAR-T cell therapy to treat cancer. Alison Sehgal, MD, is an assistant professor of medicine at the University of Pittsburgh School of Medicine, and a hematologist/medical oncologist at UPMC Hillman Cancer Center specializing immunotherapy and stem cell transplants for blood cancers.

This rapid pace at which immunotherapy has been transferred from the bench to the bedside to the point that we now have an FDA approved cellular therapy shows that CAR-T cells and immunotherapy in general are the future of cancer treatment. The UPMC Hillman Cancer Center is actively involved in several cutting edge immunotherapy and cellular therapy efforts both in basic science and clinical trials that will translate into advanced care being available for patients throughout the UPMC Hillman Cancer Center system. Dr. Allison Sehgal

To speak with Dr. Sehgal about the approval of CAR-T cell therapy, please contact Cyndy Patton.

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UPMC Hillman Cancer Center immunology expert available to talk about FDA approval of CAR - T cell therapy. - Newswise (press release)

Immunology

Multicohort analysis reveals baseline transcriptional predictors of influenza vaccination responses – Science (subscription)

August 29, 2017 student

For flu vaccines, age matters

Development of a broad flu vaccine has been hampered by lack of clear insight into protective mechanisms across individuals to seasonal vaccines. Avey et al. perform a systems-level analysis on multiple influenza vaccination cohorts spanning distinct geographical locations and vaccination seasons and identify prevaccination predictive transcriptional signatures of influenza vaccination responses. They validated nine genes and three gene cohorts that associated with magnitude of antibody response in an independent cohort. However, these signatures were specific to young individuals and had an inverse correlation in older individuals. These data may help to predict antibody response to influenza vaccination, as well as provide insights into the distinct mechanism governing immune responses in young and older individuals.

Annual influenza vaccinations are currently recommended for all individuals 6 months and older. Antibodies induced by vaccination are an important mechanism of protection against infection. Despite the overall public health success of influenza vaccination, many individuals fail to induce a substantial antibody response. Systems-level immune profiling studies have discerned associations between transcriptional and cell subset signatures with the success of antibody responses. However, existing signatures have relied on small cohorts and have not been validated in large independent studies. We leveraged multiple influenza vaccination cohorts spanning distinct geographical locations and seasons from the Human Immunology Project Consortium (HIPC) and the Center for Human Immunology (CHI) to identify baseline (i.e., before vaccination) predictive transcriptional signatures of influenza vaccination responses. Our multicohort analysis of HIPC data identified nine genes (RAB24, GRB2, DPP3, ACTB, MVP, DPP7, ARPC4, PLEKHB2, and ARRB1) and three gene modules that were significantly associated with the magnitude of the antibody response, and these associations were validated in the independent CHI cohort. These signatures were specific to young individuals, suggesting that distinct mechanisms underlie the lower vaccine response in older individuals. We found an inverse correlation between the effect size of signatures in young and older individuals. Although the presence of an inflammatory gene signature, for example, was associated with better antibody responses in young individuals, it was associated with worse responses in older individuals. These results point to the prospect of predicting antibody responses before vaccination and provide insights into the biological mechanisms underlying successful vaccination responses.