Category Archives: Neuroscience

UCI Podcast: The perils and benefits of dream incubation – UCI News

It sounds too crazy to be true: Corporations and scientists using sounds and smells to influence peoples dreams. But targeted dream incubation is not limited to the realm of science fiction. Scientists use the method to help patients overcome addictions such as smoking, and corporations have launched advertising campaigns that encourage willing participants to participate in having their dreams shaped.

Sara Mednick, a professor of cognitive neuroscience at UCI, is worried about the potential misuse of dream incubation and recently joined about 40 other sleep and dream scientists in signing an open letter voicing their concerns. In this episode of the UCI Podcast, Professor Mednick discusses how dream incubation works, and how sleep keeps people healthy.

In this episode:

Sara Mednick, professor of cognitive neurosciences

Sleep and Cognition Lab, Professor Sara Mednicks lab

Advertising in Dreams is Coming: Now What? an open letter signed by about 40 sleep and dream scientists raising concerns about dream incubation, as used for advertising

Spend Saturday Night Dreaming With Zayn Malik, a press release from February 2021 announcing an advertising campaign by Molson Coors to encourage people to participate in targeted dream incubation

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AARON ORLOWSKI, HOST

When the sleeping mind hears certain sounds or smells certain odors, the landscape of dreams shifts. Some memories are reinforced, while others grow dim. By manipulating sounds and smells, scientists and corporations are able to influence our dreams and thus our waking lives.

What are the dangers and benefits of this kind of targeted dream incubation? And how do our dreaming hours keep us healthy?

From the University of California, Irvine, Im Aaron Orlowski and youre listening to the UCI Podcast. Today, Im speaking with Sara Mednick, a professor of cognitive neuroscience at UCI.

Professor Mednick, thank you for joining me today on the UCI Podcast.

SARA MEDNICK

Thanks for having me, Aaron

ORLOWSKI

So you, along with about 40 other sleep and dream scientists, recently signed an open letter raising some alarms about a new type of advertising called targeted dream incubation. Listeners might have heard of this because Molson Coors, the beer company, generated a lot of headlines about this back in January and February when they announced a plan to use this advertising method around the Super Bowl. So I want to ask you: What is dream incubation and how does it work?

MEDNICK

The first thing to kind of understand is that sleep is a time when we are processing our recent experiences and were folding them away and putting them into long-term storage areas where they can be safe and not overwritten by the next days experiences. The idea that you could kind of interfere with this memory processing time or this sleep time has been talked about for a century, at least. But it wasnt until about 15 years ago, 10 years ago, when researchers realized that if you pair the thing that you want to remember with a specific sound while youre trying to learn it.

So if youre trying to learn the position of a lot of different objects and where they go in a puzzle and each puzzle piece has an objects face on it like a cat or a tea kettle or a dog or a car. And all of these objects have a specific sound. The cat sounds like a meow and the dog sounds like a ruff, right? And every time you place that cat puzzle piece in the specific position it goes into the puzzle, you hear the meow sound. So you tie that sound to that position in the puzzle. When you then go to sleep, you play the meow sound, right? And you play say, maybe theres a hundred puzzle pieces. Maybe you play only 50 of those puzzle pieces. And then you wake up the next day and you see how many of those puzzle pieces do you remember their location? It turns out that those sounds that you played in the middle of the night, biased that memory processing to actually only focus on the puzzle pieces that had the sound played. It reactivated specific memories, and it made the memory process focus on only those memories.

And so what happens is your performance for just the memories that you reactivated during sleep. Well, Coors decided that they could use this idea in order to make you have an association between the Coors beer and very specific sounds that were the sounds of a mountain stream or birds chirping or beautiful like very refreshing feelings and sounds. And then when they went to sleep, the subjects were played those sounds again, and woken up, right after they were probably dreaming for awhile with those sounds in their heads. And they asked them, well, what were you dreaming about? And they were dreaming about Coors.

ORLOWSKI

Wow. So this could work for any variety of objects or subjects or ?

MEDNICK

Yeah, anything you can pair a sound to. But it doesnt just have to be a sound. It could be a smell. If there was a specific thing that you wanted somebody to associate, we could use targeted memory reactivation, where we target specific memories to be reactivated during sleep. And we can increase peoples memories. But its also been shown that we can actually make people forget certain memories by doing this targeted memory reactivation. So its like a targeted forgetting, very similar to the Spotless Mind movie, where people were trying to take out memories of long lost loves that they missed, their heartbreaks. And you could actually take out that memory. Well, this is exactly that idea that you can actually during sleep, instead of remember things more, you can actually delete things.

ORLOWSKI

That is crazy. And the movie Eternal Sunshine of the Spotless Mind was quite trippy. And if I remember the characters wanted to reverse their forgetting in the end.

MEDNICK

Yeah. Its, I mean, theres just a whole bunch of potential things that it can be used for, that some of them are really great. Theres beautiful research looking at people who are smokers who want to stop smoking. And during sleep, they send in the smell of cigarette smoke into the noses of the sleeping subjects. And at the same time, they pair that smoke with the smell of rotting fish. And what they find is that that creates a negative association with the smoking. And when people wake up in the morning, they dont want to smoke.

ORLOWSKI

So this sort of dream manipulation and memory adjustment, can be used for different purposes, helping an addict overcome their smoking addiction. But also we just talked about Coors using it to encourage people to want to drink more beer. So why are you concerned about this method being used by corporations?

MEDNICK

You know, back in the day before we knew about subliminal messaging manipulating people unconsciously to buy products, there was a lot of advertisements that were sent very quickly through films and you couldnt even see them and suddenly youve got the urge to drink Coke, you know, or eat more popcorn, or whatever it was. And that was outlawed because its unfair. Its unfair that people unconsciously are being driven to do things that they dont even realize that theyre being manipulated to do. So thats, thats that thats been regulated by this point. And those rules only really actually applied to waking experience. And the thing about the law is that you need to actually be very specific or people will get around it. You need to really say, okay, you cant do the subliminal messaging, either in wake or sleep.

And particularly because sleep, youre actually even more vulnerable to messaging than you are during wake, because youre sleeping. You dont remember anything. Subjects never remember that they had sounds played or smells played. And so you have no sense of when youre being manipulated or not. The Nest system has an algorithm that knows when people are sleeping in that room. And if thats the case, then they could also play music, they can play whatever sounds that they want. And so its not a far shot to say that if you know when someones asleep, you can add information into their sleep that would be unbeknownst to them.

ORLOWSKI

Well, so weve been talking a lot about the potential nefarious uses of this type of messaging in peoples dreams, but maybe we can talk a little bit more about why people dream in the first place. What function does it serve for people to have dreams?

MEDNICK

Its a great question. And if you find out the answer, I hope Im the first person that you tell. Nobody knows. Weve been trying to figure out this question for centuries. And its one of the earliest questions known to man and woman, because weve always dreamed. Evolution hasnt pushed it away and we still dream. And we still dont know why. Theres many hypotheses. You know, Im a cognitive scientist, so I look, maybe those dreams that are helping you rehearse the information that you just learned during the day. And that may help you with that long-term storage mechanism I was talking about.

You know, dreams also have emotional content to them. And so theres an idea that while youre dreaming, youre actually rehearsing and playing out certain kinds of scenarios. Maybe youre saying, well, what would I do if an ax murderer was running after me? Like, hmm, let me see that again you know, like these recurring nightmares. Like, what would I do in this case where somebody dumps me or whatever it is. And so you have these kinds of recurrent scenarios in your mind to see, like, what are different potential strategies and outcomes that I could choose?

At the neuroscience level, the idea is that with emotional experiences, we are uncoupling the emotional areas of the brain from the memory areas. And over time, these experiences that are at first rather really emotional actually become less emotionally charged and more kind of cognitively charged, where we can start to think about them a little more rationally over time. And thats a very natural process that happens with emotional experiences and it requires sleep to have a natural progression such that, you know, eventually that breakup that you thought youd never recover from in a month, youre like, yeah, all right, well, I did this wrong or, you know, she did that wrong, or whatever it was that you want to say.

ORLOWSKI

Yeah. Unless youre in Eternal Sunshine of the Spotless Mind, in which case you just regret it eternally,

MEDNICK

And then you just keep making the same mistakes over and over and over.

ORLOWSKI

Yeah. Well, so it sounds like sleeping and dreaming essentially helps us heal. So how does our mood change after weve slept or after weve dreamed?

MEDNICK

Theres obviously the idea of sleep on it youll feel better in the morning. And it turns out that sleep may help you feel worse in the short term and better in the long-term. And you could imagine why, right? If something happened to you while you were walking home, you know, you decided to take the darker route home, and something happened to you, you dont want to just forget that thing. Its actually really protective to have a strong, emotional response to a negative experience. And what has happened is you actually have a stronger emotional response right after you wake up in those first few days. Youre really living inside that emotional response. And then over time that emotional response starts to waiver or just decrease. And what you get is this stronger and stronger cognitive response. Those are really natural protective mechanisms that teach us not to do these things that didnt work out anymore.

ORLOWSKI

Yeah. Well, you mentioned earlier that we are especially vulnerable to messaging while were asleep and, and more so than when were waking. And I guess on one level that seems kind of intuitive, but can you tell us more about why thats the case?

MEDNICK

Many people wake up and they have no idea what they dreamed, right? Your hippocampus is a brain area that takes in new information. And sometimes its, its on, a of the times its on during sleep, but the part of the brain that really connects to the long-term memory and to really storage and to holding on the information, is also the frontal cortex. And the frontal cortex when youre sleeping is totally turned off. So you may have this connections to what recently happened and then what happened 10 years ago to you, and you have these dreams that are making wild connections between all these different experiences and that recent thing that just happened to you.

But when you wake up in the morning, you dont remember any of these things. And thats probably a good idea, right? Because you really want to focus on the things that are real. And the dream time may be some subconscious practice that youre getting through, some process that youre working through. But you dont want to hold onto your dreams per se, more than your waking life. So its actually sort of evolutionarily better to not necessarily be carrying your dreams around all day, but that also means that you dont know what happened to you in the middle of the night, if your dreams were suddenly full of Coors commercials.

ORLOWSKI

Yeah. You might not know how that got there, how those arrived.

MEDNICK

Yeah, you definitely wouldnt.

ORLOWSKI

Yeah, well, and I want to ask you one final thing. If I just want to get good sleep, what steps should I take? Youve studied many people or many components of sleeping and how to increase quality sleep. So what are the best actions to take?

MEDNICK

Theres so many different things that can be done. And theres a whole list of any website will tell you what sleep hygiene tips to take. But some of the ones that dont necessarily get recommended, but I recommend is getting to sleep early. Because the sleep that you get in the first part of the night is different than the sleep that you get in the morning. So the idea that you can get to sleep late and then sleep a little bit later in the morning, youre not actually getting the sleep thats the really good sleep. Whats called slow-wave sleep happens in the first part of the night. And thats the stuff that does all the clearance of toxins from the brain. And when people get older, they have less and less slow-wave sleep and more and more buildup of these toxins that can lead to the plaques that develop with Alzheimers. And also a lot of this memory consolidation stuff that weve been talking about all happens during slow-wave sleep. So really getting to sleep early, Im talking like 10 p.m., is very important for getting that early deep sleep that is the most restorative that we have.

Another thing is to make sure that when you wake up in the morning, you go outside and you get some sun. We are rhythmic animals and the sun is the strongest whats called entrainer, basically. Its the downbeat for our day. And when you get bright light early in the morning, that sets you up to actually be ready for sleep at night. And if you dont have bright light, maybe its the winter time and youre on the East Coast or something, get one of these really strong all spectrum lights and just have it for 15 minutes on while youre having your breakfast in the morning. I could go on and on, but reduce blue screens after 6 p.m. The blue light is really strong inhibitors of melatonin, which is a sleep hormone. And so you want to make sure that after 6 p.m., youre really trying not to get in front of any fluorescent lights or any lights that dont have some filters on them.

ORLOWSKI

Professor Mednick, thank you so much for joining me today on the UCI Podcast.

MEDNICK

Thanks for having me. It was super fun.

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UCI Podcast: The perils and benefits of dream incubation - UCI News

A new class of memory cells discovered in the brain – Tech Explorist

How the brain recognizes the faces of familiar individuals has been important throughout the history of neuroscience. But the proposed cells that link visual processing to person memory are not found yet.

A new study reported the discovery of such cells in the brains temporal pole region that links face perception to long-term memory. Scientists from the Rockefeller University have a new class of memory cells that collectively remembers faces.

Scientists used fMRI as a guide to zoom in on the TP regions of two rhesus monkeys. They then recorded the electrical signals of TP neurons as the macaques watched images of familiar faces and unfamiliar faces that they had only seen virtually on a screen.

When subjects had seen familiar faces, their neurons in the TP region were highly selective. After processing the image, these neurons found to fastdiscriminating between known and unknown faces.

Strangely, these cells responded threefold more strongly to familiar over unfamiliar faces despite the fact that the subjects had seen the unfamiliar many times on screens.

Neuroscientist Sofia Landi, first author on the paper, said, This signifies the importance of knowing someone in person. Given the tendency nowadays to go virtual, it is important to note that faces that we have seen on a screen may not evoke the same neuronal activity as faces that we meet in person.

Winrich Freiwald, professor of neurosciences and behavior at The Rockefeller University, said,The cells of the TP region behave like sensory cells, with reliable and fast responses to visual stimuli. But they also act like memory cells that respond only to stimuli that the brain has seen beforein this case, familiar individualsreflecting a change in the brain due to past encounters. Theyre these very visual, very sensory cellsbut like memory cells. We have discovered a connection between the sensory and memory domains.

The discovery of the TP region at the heart of facial recognition means that we can soon start investigating how those cells encode familiar faces. We can now ask how this region is connected to the other parts of the brain and what happens when a new face appears. And of course, we can begin exploring how it works in the human brain.

In the future, the findings may also have clinical implications for people suffering from prosopagnosia, or face blindness, a socially isolating condition that affects about one percent of the population. Face-blind people often suffer from depression. It can be debilitating because in the worst cases, they cannot even recognize close relatives.

This discovery could one day help us devise strategies to help them.

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A new class of memory cells discovered in the brain - Tech Explorist

There’s A Simple Way To Feel Happier, According To The New Science Of Emotion : Shots – Health News – NPR

Back in the fall, Michelle Shiota noticed she wasn't feeling like herself. Her mind felt trapped. "I don't know if you've ever worn a corset, but I had this very tight, straining feeling in my mind," she says. "My mind had shrunk."

Shiota is a psychologist at Arizona State University and an expert on emotions. When the COVID-19 crisis struck, she began working from home and doing one activity, over and over again, all day long.

"I will be honest, for the past 14 months, I have spent most of my waking hours looking at a screen, either my laptop, my phone or a TV screen," she says, often from the same sofa, in the same room in her San Francisco home. All that isolation and screen time had taken a toll on Shiota.

During the pandemic, many people have felt their mental health decline. The problem has hit essential workers and young adults, ages 18 to 24, the worst, the Kaiser Family Foundation reported in May. The percentage of adults with signs of anxiety or depression has grown threefold, from about 10% to 30%.

Although some people are starting to test the waters of public life again, planning vacations and socializing more, others may still have lingering signs of what psychologists call languishing. They may feel an emptiness or dissatisfaction in day-to-day life. Or feel like they're stuck in weariness or stagnation.

Luckily, an emerging area of brain science has a new way to help lift yourself out of languishing and bring more joy into your life. It worked for Shiota.

"I had to expand my consciousness," she says. And she did it by intentionally cultivating a particular emotion.

Explore ways to cultivate well-being with NPR's Joy Generator.

For thousands of years, there's been a common belief in Western culture about emotions that they are hard-wired and reflexive, psychologist Lisa Feldman Barrett writes in the book How Emotions Are Made: The Secret Life of the Brain. "When something happens in the world ... our emotions come on fast and uncontrollable, as if somebody flipped a switch," she writes.

But when researchers look at what's going on inside the brain and inside the body during specific emotional states, the theory doesn't hold up.

Over the past decade, neuroscientists have begun to shift how they think emotions arise. Rather than being inevitable, hard-coded experiences, researchers now think emotions are malleable, and people have more influence over them than previously thought.

Say for example, you're walking in the woods, and you see a grizzly bear, says neuroscientist Anil Seth at the University of Sussex. "You recognize it's a bear," he says, "and then what happens?"

Previously researchers thought the emotion comes first. "You see a bear and then you feel afraid," Seth says. "Because you're afraid, your brain then jacks up your adrenaline levels."

Your heart rate rises. Your breath quickens. Your pupils dilate. And blood rushes to your skeletal muscles. The old theory was that "the fear sets in train all kinds of flight and fight responses so that you are well-prepared to run away and live another day," he adds. In other words, the emotion (i.e., fear) triggers the physiological responses (i.e., an adrenaline rush).

But according to the latest research, the human body probably works the other way around, Seth says. "The brain registers a grizzly bear, and that perception sets in train all the physiological responses." You get an adrenaline rush. Your heart rate goes up. You start breathing faster. Blood rushes to your muscles. And then the emotion comes.

The brain senses these physiological changes and decides which emotion to conjure up. The emotion is an interpretation of what's going on both inside the body (the adrenaline rush) and the outside of the body (the sight of the bear). "The brain has to figure out what caused the sensory signals," Seth says.

The chosen emotion not only helps the brain make sense of these signals, but it also helps the brain predict better the immediate future and how to handle the situation at hand. Which emotion would be most useful? Which emotion will help me survive?

To figure that all out, Seth says, the brain uses one more piece of information and this part is key. The brain takes into account your past experiences, your memories.

Let's return back to that encounter with the grizzly bear. If your past experiences with bears come largely through news reports of attacks and maulings, then your brain will likely interpret your bodily sensations raised heart rate, raised blood pressure, sweaty palms as fear. Lots of fear! And this emotion will help drive you away from the bear. "So you can live another day," Seth says.

But what if your family hunts for a living? And your past encounters with a bear ended in a wonderful feast for you and your neighbors. Then your brain may interpret the adrenaline rush the heavy breathing and raised heart rate as excitement. This positive emotion will help drive you forward toward the bear, while all the physiological changes help you bring home dinner.

"Your brain uses memories from the past in order to create the present," says Barrett, who also does neuroscience research. "It's bringing knowledge from the past to make sense of the immediate future, which then becomes your present."

Neuroscientists call this "the predictive brain." Understanding how these predictions work is "very powerful knowledge," Barrett says. It means that emotions aren't hard-wired reactions to particular situations, which are out of your control (i.e., you see a bear and therefore you must feel afraid). But rather it's the opposite. "You can, in fact, modify what you feel in very direct ways," she says.

It's not about trying to force a happier or less fearful feeling in the moment, Barrett says. But rather, it's all about planning ahead. You can stack the deck in favor of your brain, choosing positive, uplifting emotions in two major ways, she says.

The first one is a no-brainer: You can take care of your body physically. According to this new theory, the brain constructs emotions based largely on physiological signals and other sensations from your body. So by boosting your physical health, you can decrease the chance your body will send unpleasant signals to your brain and, in turn, increase the chance, your brain will construct positive emotions instead of negative ones. "You can get more sleep. You can eat properly and exercise," she says.

The second approach to influencing your emotions may be less familiar but likely just as impactful: You can "cultivate" the emotions you want to have in the future.

"If you know that your brain uses your past in order to make sense [of] and create the present, then you can practice cultivating [positive] emotions today so that your brain can automatically use that knowledge when it's making emotions tomorrow," Barrett says.

By practicing particular emotions, you can "rewire" your brain, she says. "Your brain grows new connections that make it easier for you to automatically cultivate these emotions in the future." So when you start to feel a negative emotion, such as sadness or frustration, you can more easily swap that negative feeling for a positive one, such as awe or gratitude.

"For example, when I am video chatting with somebody in China, I can feel irritated very easily when the connection isn't very good," Barrett says. "Or I can feel awe at the fact that someone can be halfway around the world, and I can see their face and hear their voice, even if it is imperfect, and I can be grateful for that ability."

In this way, emotions are a bit like muscle memory. If you practice the finger patterns for a chord on the piano, a few minutes each day, eventually your fingers can play those chords with little thought. The chords become second nature.

The same goes for emotions. To help pull out of the pandemic blues, it's time to start "practicing" positive emotions and it won't take as much as learning all the chords.

All you need is about five to 10 minutes, says psychologist Belinda Campos at the University of California, Irvine. "Hopefully it wouldn't take people as much effort as it does to eat healthier or to exercise," she says. "Positive emotions feel good. I think people will find them rewarding enough to return to them and keep doing them."

Scientists say this practice is helpful to prevent or work with everyday doldrums and weariness. It isn't intended as a replacement for treatments, such as counseling and medication, for serious mood disorders or anyone going through intense or prolonged bouts of depression.

A few decades ago, scientists used to lump together all kinds of positive emotions into one concept: happiness. Since then, a group of psychologists, including Campos and Shiota, figured that there is a whole "family tree" of positive emotions, including pride, nurturant love, contentment, nostalgia, flow, gratitude and awe.

One reason these emotions often make us feel good is they shift our focus away from the self that is "me and my problems" and onto others, Campos says. "They help put the self in its balanced place, of not being absolutely the highest thing on the to-do list. They help us focus on the joys that relationships can bring."

She adds, "In this way, positive emotions are part of what helps you to put others before the self." And helping others often makes people feel good. "So, for example, people report levels of higher well-being when they're giving to others, and it can feel better to be on the giving end rather than the receiving end," she says. "I think that's more evidence that focusing on others can be really good for us."

The idea of cultivating positive emotions is pretty simple. Choose one of these emotions and then do a specific action regularly that helps evoke it. Psychologists have devised suggestions for how to get started, but it can be as simple as taking time to notice and appreciate the small things around you that uplift you. (Read three tips to get started at the end of this piece.)

Over time, your brain will start to use these emotions more often and turn to negative emotions less frequently.

Take, for instance, gratitude.

For the past year and a half, Dr. Sriram Shamasunder has been on the front lines of the COVID-19 pandemic. Shamasunder is a physician at the University of California, San Francisco, and he spends about half his time in low-income communities around the world.

To help bring more "light" into his life, Shamasunder started to keep a gratitude journal. It was part of a project for the Greater Good Science Center at the University of California, Berkeley.

Each day, Shamasunder simply jotted down things around him for which he was grateful. "So not necessarily spending a whole lot of time racking my mind, but just everyday occurrences that were powerful or meaningful or just simple and beautiful," Shamasunder told The Science of Happiness podcast. He jotted down the doctors and nurses working on Sunday, "the unseen hands who created a vaccine," "the evening light, magical and orange and blue," and a tree outside that provides refuge to birds, ants and squirrels.

By intentionally cultivating gratitude, for even a short period each day, Shamasunder found it easier to evoke positive feelings throughout the day. "The act of naming the gratitudes carried into the next day and the next, where I became more aware of things in my life that I should cherish in the moment, or I need to cherish."

Back in the fall, when Shiota, the Arizona State psychologist, felt her mind shrinking, she knew exactly which emotion she needed to cultivate.

She got up off the couch, drove West from her San Francisco home and ended up at the edge of the ocean. "I am trying to reconnect with the vast natural world, with the universe beyond my professional and personal responsibilities, and beyond this moment in time," Shiota writes in the Annals of the New York Academy of Sciences. "I am searching for awe."

Shiota is a world expert on awe. She says the emotion is difficult to define, "but I think that what we are dealing with is a change that happens in our mind and in our bodies and in our feelings when we encounter something so extraordinary that we can't explain it."

That encounter can be with something grand, such as a panoramic view of a red sun dipping into the Pacific Ocean. It can be with something minuscule, such as the black spots on a ladybug. (How did they get so perfectly round?) It can be a scent, a taste or sound. "It can be a very complex and powerful song that you've never heard before or even a scene in a TV show," Shiota says.

Whatever it is, the extraordinariness of the event makes you pause, for a bit, Shiota says, and try to figure it out. How does a rose smell like a lemon? Why does a perfectly ripened peach taste so good? "We simply slow down our body, slow down," Shiota says.

And this pause calms your body. "I've found evidence that the activation of our fight-flight sympathetic nervous system dials back a little bit."

The feeling of awe also widens your perspective, she says which Shiota desperately needed after spending so much time looking at screens. "I had to consciously force myself to look further away. I had to let my senses my sight, my sound, take in a broader scope of what was going on around me."

In addition to going to the beach, Shiota also simply walked around her neighborhood, looking for unexpected and inspiring things.

"There was this amazingly elaborate, chalk drawing in recognition of somebody's birthday. There was a couple, in which one person was clearly helping the other learn to roller-skate on the San Francisco hills. And they're clinging on to each other for dear life," she says with a chuckle. "Then the flowers! If you look closely at flowers, in a way that you never take the time to do, you'll see how incredibly intricate they are.

"So the opportunities for awe are there," she says. "Look for what moves you, what pushes your sense of boundaries of what is out there in the world."

It took a little time and patience Shiota says, but eventually these "awe walks" helped her recover from her pandemic funk. Practicing awe released her mind from that constraining "corset."

"Then my mind was able to spread out and take up the space that it needs to take to feel OK," she says. And once her mind released, her body followed. "When you take off the corset, your whole body goes, 'Oh, oh! That's much better.' "

Psychologists say you can improve your well-being if you recognize moments of positive feelings, value them and seek them out more often. Below, find a few other ideas for cultivating positive emotions and turning happiness into a habit. To explore more ideas, check out NPR's Joy Generator.

1) Share some appreciation: Campos recommends this simple practice. Get together with some friends and write out on cards three things that you're grateful for in the other person. Then share the cards with each other.

"We're using this task right now in my laboratory, and it seems to be very evocative of positive emotion," she says. And though the data is preliminary, she says, "what we see so far is that people enjoy writing what they appreciate in others, and they enjoy sharing it with the other person. It seems to be affirming bonds." Sometimes it even ends in hugs.

2) Take an awe walk: Take a five-minute walk outside each day where you intentionally shift your thoughts outward. Turn off your cellphone or even better don't bring it with you. "Focus your attention on small details of the world around you," psychologist Piercarlo Valdesolo at Claremont McKenna College suggests. Look for things that are unexpected, hard to explain and delightful.

For example, take a moment and find a crack in the sidewalk, where a weed is poking out, Barrett says. And let yourself feel awe at the power of nature. "Practice that feeling over and over again," she says. "Practice feeling awe at colorful clouds, an intricate pattern on a flower or the sight of a full moon."

3) Listen to a calm concert: A recent meta-analysis from the University of Michigan found that sounds of nature, including birdsongs and water sounds, lower stress, promote calmness and improve mood. Find a bench in your neighborhood under a tree or near water. Sit down, close your eyes and consciously listen to the natural sounds around you. Listen for birdsongs, rustling wind or trickling water. Try sitting for at least five minutes whenever you get a chance. Allow and enjoy calm to wash over you.

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There's A Simple Way To Feel Happier, According To The New Science Of Emotion : Shots - Health News - NPR

Neuroscience (and a Tiny Dose of Emotional Intelligence) Reveals the Simple Trick to Break Nearly Any Bad Habit – Inc.

Nice piece of grilled salmon. Brown rice. Salad with no dressing. I feltfull: Not stuffed, but satisfied. Better yet,I felt good about having eaten a healthy meal.Then the ice cream called me.

Think you make a lot of decisions? You do, but not as many as you think.Research shows that approximately 40 percent of the things we do on a daily basis aren't decision-based. They're habits.

And someare bad habits.

Which doesn't, at first glance, make sense."We find patterns of behavior that allow us to reach goals," says Dr. Wendy Wood, the author of Good Habits, Bad Habits."We repeat what works, and when actions are repeated in a stable context, we form associations between cues and response."

So why do we form habits that don't help us reach our goals? My goal is to maintain a healthy weight, and eating ice cream is a far fromsupportivepattern of behavior.

Because neuroscience -- theway our brains are made -- oftenworks against us. (H/t to Eric Barker for the underlying science.)

Say I ask myself, "Should I have some ice cream?" My prefrontal cortex -- thebrain region responsible forplanning,decision making,and supporting goal-oriented behaviors-- would answer, "Nope. Your goal is to eat healthy."

Except my orbitofrontal cortex -- the brain region responsible for emotion and reward in decision-making -- would answer, "Dude, you absolutely should! Ice cream is awesome. You love it. It makes you happy. Besides, you can always burn the calories off by working out a little extra tomorrow..."

Because while my prefrontal cortexis alogical and rational kind of guy, he's fairly quiet and subdued. My orbitofrontal cortex? He's a yeller. He's insistent. He loves to get his way.

And he loves to create bad habits.

Or, as Dr. Wood explains inneuroscientificterms, "When our intentional mind is engaged, we act in ways that meet an outcome we desire -- and typically we're aware of our intentions. However, when the habitual mind is engaged, our habits function largely outside of awareness. We can't easily articulate how we do our habits or why we do them...our minds don't always integrate in the best way possible."

In short, give my orbitofrontal cortexa chance and I'll quickly establish some bad habits. I'll do things reflexively, almostwithout thinking.

If I do manage to think, "Wait, should I really have ice cream...?" that little voice in my head getsdrowned out by my orbitofrontal cortex and the force of habit.

And yep, I'm screwed. Now my goal isn't to achieve something positive by repeatingwhat works. My goal is just to satisfy my habit of eating ice cream. So I do. Without really thinking.

Because if I thought about it, I wouldn't be likely to do it.

As Dr. Wood says, "Habits allow us to focus on other things. Willpower is a limited resource, and when it runs out, you fall back on habits." (If you're like me, you can almost feel a switch flipping in your mind that instantly shuts off any rational thoughts.)

So how do you break that cycle?

The answer is simple, yet difficult: You have to force yourself to think: Not before, but during.

Not, in my case,not before I eatthe ice cream -- because that requires willpower I clearly don't have -- but while I'm eating the ice cream.

The key is to reflectupon the actual benefits derivedfroma habit. For me? Ice cream tastes good. Ice cream... well, that's pretty much the list.It don't feel healthier. I don't feel better when I'm finished. In fact, I feel worse;maybe not physically, but definitelyemotionally.

One upside,lotsof downsides.

And then repeat the process, because one period of reflection and introspection won't be enough. I'll probably have to do it several times before it sinks in -- before my orbitofrontal cortex adopts the rewards and emotions involved in not feeling badabout eating ice cream andnot feeling like I'm sabotaging my health and fitness goals.

Then those two voices will speak in unison. My prefrontal cortexwill share all the long-term benefits ofeating healthy. My orbitofrontal cortex will chime in withreasons why skipping theice cream willmakeme feel better in the moment. In emotionalintelligence terms, myemotions will work for me, not against me.

And that's how the habit gets broken.

Try it. Say, like my Inc. colleague Justin Bariso, you want to stop watching YouTube videos when you know you should be working. The next time the urge strikes, don't fight it. Watch a video.

But don't do it mindlessly: Think about what you're watching. Is it entertaining? Do you gain any value from it? Is it more fun -- or more rewarding or fulfilling or satisfying --than doing something else?

What do you really get out of it?

Do that enough times, reflect on the actual feelings and benefits that result from a habit, and in time you'll start to make a different choice.

Because then yourintentional and habitual minds won't have to work againsteach other.

They'll be able to work together.

The opinions expressed here by Inc.com columnists are their own, not those of Inc.com.

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Neuroscience (and a Tiny Dose of Emotional Intelligence) Reveals the Simple Trick to Break Nearly Any Bad Habit - Inc.

Norton Healthcare to open comprehensive neuroscience facility – Norton Healthcare

On June 17, Norton Healthcare will open a comprehensive neuroscience facility unlike any other in the region. This new facility will benefit patients and the community by providing a comprehensive, multidisciplinary neurosciences program with leading-edge technologies and enhanced research and outreach efforts.

The Norton Neuroscience Institute space, located in Norton Medical Plaza III on the Norton Brownsboro Hospital campus, will support patients with many types of neurological conditions, including brain, spinal and nervous system tumors; stroke; epilepsy; migraine and headache; dementia; and memory care. It also will be home to Norton Neuroscience Institutes Cressman Parkinsons & Movement Disorders Center and Cressman Neurological Rehabilitation, as well as a pain management clinic.

The new space encompasses more than 48,000 square feet of clinical, diagnostic, procedural and rehabilitation space. It contains advanced equipment to allow patients to undergo complex neurological testing and procedures at the same site as their routine office visits. Norton Healthcare invested $15 million into the project.

Neuroscience treatment is rapidly evolving, and were committed to bringing the best care to patients throughout this community, said Russell F. Cox, president and CEO, Norton Healthcare. With this location, patients will be able to receive compassionate, specialized care with the newest technology and equipment, all in one convenient location. This space is designed not only to address patients needs but also to aid in the comfort and ease of their care and recovery.

Many neurological conditions require treatment by multiple providers. Having a centralized location will allow the team to more easily collaborate to develop individualized courses of treatment. Located next to Norton Brownsboro Hospitals Comprehensive Stroke Center and Level 4 epilepsy center, the space also will improve access to follow-up care after patients leave the hospital.

Having dedicated space for comprehensive neurological care and rehabilitation will make it much easier for us to convene in person and develop customized treatments for each patient, said David A. Sun, M.D., Ph.D., neurosurgeon and executive medical director, Norton Neuroscience Institute. We believe this level of collaboration sets us apart from other neuroscience centers.

The new Cressman Neurological Rehabilitation space is equipped with the latest rehab technology, including a virtual reality balance assessment system, a driving simulator, robotic-assisted therapy and more, which will help patients recover and develop skills to live independently. It was made possible thanks to a $616,000 grant from the Norton Healthcare Foundation.

More than a decade ago, Norton Healthcare invested $100 million and created a vision to build one of the best neuroscience programs in the country, and this facility will help us realize that goal, said Lynnie Meyer, Ed.D., R.N., CFRE, senior vice president and chief development officer, Norton Healthcare. The Norton Healthcare Foundation has provided millions of dollars in funding to Norton Neuroscience Institute for Cressman Parkinsons & Movement Disorders Center, memory care, and other vital programs. We look forward to continuing to support their impactful work for years to come.

Classes currently offered through the Norton Neuroscience Institute Resource Center, such as tai chi, yoga, Lego therapy and patient support groups, will be offered at the new facility. These programs have been held virtually during the pandemic, but the goal is to go back to in-person classes in the near future.

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WVU Rockefeller Neuroscience Institute first in region, among first in US to offer latest deep brain stimulation technology for patients with…

WVU Rockefeller Neuroscience Institute first in region, among first in US to offer latest deep brain stimulation technology for patients with Parkinson's  WVU Medicine

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WVU Rockefeller Neuroscience Institute first in region, among first in US to offer latest deep brain stimulation technology for patients with...

Global Neuroscience Industry (2020 to 2027) – Key Market Trends and Drivers – ResearchAndMarkets.com – Business Wire

DUBLIN--(BUSINESS WIRE)--The "Neuroscience - Global Market Trajectory & Analytics" report has been added to ResearchAndMarkets.com's offering.

Amid the COVID-19 crisis, the global market for Neuroscience estimated at US$30.3 Billion in the year 2020, is projected to reach a revised size of US$37 Billion by 2027, growing at a CAGR of 2.9% over the analysis period 2020-2027.

Whole Brain Imaging, one of the segments analyzed in the report, is projected to record a 2.6% CAGR and reach US$7.9 Billion by the end of the analysis period. After an early analysis of the business implications of the pandemic and its induced economic crisis, growth in the Neuro-Microscopy segment is readjusted to a revised 2% CAGR for the next 7-year period.

The U.S. Market is Estimated at $8.9 Billion, While China is Forecast to Grow at 2.8% CAGR

The Neuroscience market in the U.S. is estimated at US$8.9 Billion in the year 2020. China, the world's second largest economy, is forecast to reach a projected market size of US$6.6 Billion by the year 2027 trailing a CAGR of 2.8% over the analysis period 2020 to 2027. Among the other noteworthy geographic markets are Japan and Canada, each forecast to grow at 2.6% and 2.5% respectively over the 2020-2027 period. Within Europe, Germany is forecast to grow at approximately 3% CAGR.

Electrophysiology Segment to Record 1.8% CAGR

In the global Electrophysiology segment, USA, Canada, Japan, China and Europe will drive the 1.9% CAGR estimated for this segment. These regional markets accounting for a combined market size of US$3.2 Billion in the year 2020 will reach a projected size of US$3.7 Billion by the close of the analysis period. China will remain among the fastest growing in this cluster of regional markets. Led by countries such as Australia, India, and South Korea, the market in Asia-Pacific is forecast to reach US$4.1 Billion by the year 2027.

Select Competitors (Total 41 Featured):

Key Topics Covered:

I. METHODOLOGY

II. EXECUTIVE SUMMARY

1. MARKET OVERVIEW

2. FOCUS ON SELECT PLAYERS

3. MARKET TRENDS & DRIVERS

4. GLOBAL MARKET PERSPECTIVE

III. MARKET ANALYSIS

IV. COMPETITION

For more information about this report visit https://www.researchandmarkets.com/r/i9nznw

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Global Neuroscience Industry (2020 to 2027) - Key Market Trends and Drivers - ResearchAndMarkets.com - Business Wire

The Neuroscience and the Treatment of Tinnitus : The Hearing Journal – LWW Journals – LWW Journals

Tinnitus, or ringing in the ears, is a common audiological complaint that is extremely heterogeneous in presentation, etiology, and severity.1 Tinnitus affects approximately 50 million Americans,2 with a similar worldwide prevalence.3 It is the number one service-related disability among U.S. veterans, affecting more than 2.17 million military members.4 There is also an increased prevalence of tinnitus in elderly populations, with estimates as high as 20% in adults over the age of 50.5 Tinnitus has many societal and economic impacts, with some studies estimating the annual tinnitus-related health care cost to be between $700 and $2,000 (USD) per individual.6,7

Shutterstock/Axel_Kock, tinnitus, neuroscience, hearing loss.

In addition to its high prevalence, the heterogeneity of tinnitus has complicated both research and clinical management of the disorder.1 Many documented causes of tinnitus include conductive and sensorineural hearing loss, ototoxicity, head and neck injury, and others.8 Tinnitus severity exists on a wide spectrum ranging from mildly bothersome to severely debilitating. The percept itself is also incredibly variable as some patients report a buzzing, whooshing, pure tone, or other indistinct sounds. Yet it remains unclear whether common or different mechanisms underlie tinnitus with different causes and clinical presentations.1 Importantly, there is neither a cure nor FDA-approved drugs for tinnitus. Many current clinical strategies are focused on alleviating the negative emotional effects of tinnitus without addressing the biological processes that underlie the phantom percept. Our review describes the current basic and clinical research of the physiological correlates of tinnitus and mechanism-driven drug development efforts.1

Tinnitus is the persistent, involuntary, subjective phantom percept of internally generated, indistinct, nonverbal noises and tones. In most cases, tinnitus is initiated by acquired hearing loss and maintained only when this loss is coupled with distinct neuronal changes in auditory and extra-auditory brain networks.1 The exact geometry of the electrical patterns of activity that are necessary and sufficient for the generation and maintenance of tinnitus lies within these networks, but the precise patterns and mechanisms remain unclear.1

In the last 30 years, tinnitus has gained more research attention. Recent progress in tinnitus research can be largely attributed to the development of tinnitus behavioral models in rodents beginning in the 1980s. Animal models are either operant or reflexive; both types are predicated on the idea that tinnitus alters the perception of silence. Operant models are based on the training of animals to behave differently in silence vs. noise. Reflexive models are based on differences in innate reflexes in response to acoustic stimulation or silence. While both models have significantly advanced tinnitus research, we propose that operant tinnitus animal models can assess the cognitive aspects of tinnitus and thus are more suitable for determining tinnitus mechanisms.

Utilizing tinnitus animal models, one of the earliest findings in tinnitus animal research is tinnitus-related neuronal hyperactivity in the dorsal cochlear nucleus (DCN),9,10 an auditory brainstem nucleus. A shift in the voltage dependence of KCNQ potassium channels was found to underlie the tinnitus-related hyperactivity and tinnitus vulnerability,11 while compensatory plasticity of HCN cation-specific channels may underlie resiliency to tinnitus after noise exposure.12 In addition to intrinsic neuronal excitability in the DCN, reduced GABAergic10 and glycinergic inhibitory transmission,13 as well as altered spike-timing plasticity between auditory and somatosensory inputs, contribute to tinnitus-related hyperexcitability.14 Tinnitus plasticity mechanisms have also been studied in other auditory nuclei. There have been somewhat conflicting findings in the inferior colliculus (IC). Namely, IC studies show increases, decreases, or no change in neuronal activity in the IC of tinnitus mice.15-20 Abnormal bursting and hyperactivity have been observed in the auditory thalamus.21 This aberrant thalamic firing has been linked to tinnitus22 and is hypothesized to play a role in the generation of pathological brain rhythms.23 Four main tinnitus correlates have been proposed in the auditory cortex: increased spontaneous firing, increased neural synchrony, increased gain, and tonotopic map reorganization. In addition to auditory areas, current research supports the involvement of non-auditory areas such as the parahippocampus and frontostriatal networks. Parahippocampal networks might play a role in the maintenance of tinnitus by encoding the memory of the tinnitus percept and subsequently reinforcing involuntary auditory memory and perception, while the pathological function of frontostriatal networks enhances tinnitus percepts by failing to suppress unwanted or insignificant percepts (gating). Overall, auditory, emotional, mnemonic, and attention networks are involved in the generation, maintenance, and severity of tinnitus.1

There are currently no FDA-approved therapeutics for tinnitus. The most commonly used therapies include sound-based therapies, such as hearing amplification and masking, and counseling or cognitive behavior therapy (CBT). These approaches are designed to decrease the awareness of the percept or manage the emotional effects of tinnitus but do not target the underlying pathophysiological mechanisms. Recently, significant progress has been made toward the development of device-based therapies such as bimodal (auditory and trigeminal or vagus nerve) stimulation, transcranial magnetic stimulation, and deep brain stimulation. These approaches are aimed to reverse pathogenic plasticity or promote corrective plasticity (rehabilitation) in the brain.

We place a special emphasis on mechanism-driven drug development informed by basic research findings.1 Several compounds are under clinical or preclinical investigation for the treatment of tinnitus, including KCNQ potassium channel openers that aim to reduce hyperexcitability in the auditory brainstem, a Group II mGluR agonist to reduce hyperexcitability in the inferior colliculus, NMDAR channel antagonists to reduce excitotoxicity in the cochlea after noise exposure, a glutathione peroxidase (GPx) inhibitor, and a T-type calcium channel blocker to reduce inflammation after noise exposure and in subsequent tinnitus.

A crucial missing piece in tinnitus research is a mechanism-driven classification system that objectively measures tinnitus and accounts for the observed heterogeneity. Perhaps the biggest of these challenges is the lack of an objective tinnitus measurement.24,25 Current tinnitus diagnostic criteria rely on standard audiometry and self-report measures that subjectively assess how bothersome tinnitus is to the patient. The current classification of tinnitus patients also represents a significant challenge. The lack of effective patient stratification likely contributes to negative or conflicting clinical trial results. Given this heterogeneity, a neuroscience-based precision medicine approach will facilitate clinical trials, treatment, and cure. The use of objective neurophysiological measures (e.g., EEG, MRI, MEG, ABR) or biomarkers (e.g., blood or DNA sampling) may be more useful and reduce experimental variability. Taken together, the future of tinnitus research and drug development must include objective measures, mechanism-driven treatments, and precision medicine approaches.26

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The Neuroscience and the Treatment of Tinnitus : The Hearing Journal - LWW Journals - LWW Journals

Clinical neuroscience and long covid – The BMJ – The BMJ

As of the 8 June 2021, there have been over 170 million cases of covid-19 and 3.7 million deaths worldwide. In the UK, over 4.5 million cases have been reported with a total of approximately 127,500 deaths. [1,2] However, it is well recognised that case numbers and deaths from covid-19 globally are probably under reported.

Beyond the acute symptoms of covid-19, there is the spectre of long covid for many. Estimates suggest that long covid symptoms are found in 13% of patients at 28 days and in 22% 5-12 weeks from the onset of acute infection [3-6]. We simply do not yet know the full scale of the problem.

Long covid may be the result of several possible pathological mechanisms that have not yet been conclusively determined [3,7,8]. A spectrum of risk factors is likely, such as severe acute infection and a lengthy in-patient stay. Demographic factors may play a partolder women and people with a high body mass index seem particularly affected. Neurological and neuropsychiatric symptoms in long covid such as autonomic dysfunction and fatigue are likely to be some of the most challenging problems to understand and treat. Autonomic dysfunction may be found to be a risk factor for symptom persistence, as well as a possible mechanism involved in long covid. [9] To understand the clinical implications of long covid fully, however, more information is required.

So far little evidence is available to guide the management of long covid in clinical practice. Physical and psychological rehabilitation is needed, but only generalised treatment is possible until we understand the patterns and factors causing persistent symptoms. Recommendations from the National Institute for Health and Care Excellence (NICE) for routine blood, cardiac, and respiratory function tests do not include assessment of neuropsychiatric, neurological, and pain symptoms even though these predominate in surveys of patients with long covid. [3] We argue that in-depth assessment from these specialities will provide a more holistic approach to managing patients with long covid. To achieve this, it is necessary for clinical services to be re-aligned to cover shortfalls in funding, staff, and clinical leadership to deliver longterm care to these patients. The economic fallout from the pandemic means that such resources may be scarce for the foreseeable future, but generic treatments based on traditional rehabilitation models may waste valuable time and money unless specific patient vulnerabilities are first identified. To achieve this, evidence should be synthesised in a living format such as a living systematic review (LSR). LSR is defined by the Cochrane community as a systematic review that is continually updated, incorporating relevant new evidence as it becomes available, allowing better use of data from existing electronic health records to enable evidence-based practice.

To date, it is unknown whether covid-19 variants affect the risk of long covid. Different variants seem to affect virulence and acute symptoms, such as anosmia, but it remains unknown whether new variants could trigger unexpected post-infectious symptoms, emulating the possible link between the 1918 influenza pandemic, Middle East respiratory syndrome (MERS), severe acute respiratory syndrome (SARS), and encephalitis lethargica. [11] Furthermore, it remains to be seen whether vaccination in those previously infected affects the risk of long covid.

The fear of influenza-covid co-infection did not materialise until late in 2020. Strict covid-19 restrictions are now being eased in many parts of the world, including the UK. Only time will tell whether this will increase the risk of joint or sequential infections in the future. Covid and influenza vaccinations may reduce the risk of the overall burden of severe acute infection but may not affect prolonged post-infectious symptoms.

Collecting epidemiological data, identifying symptom clusters, and evaluating representative patients on the basis of these could provide insights into long covid. Life-course epidemiological methods may be useful when constructing studies to explore long covid. Intensive clinical research that could be set up rapidly alongside evidence synthesis may lead to a better understanding of the pathophysiology of long covid. Furthermore, such research may benefit patients with pre-existing neurological disorders, such as Parkinsons disease, multiple sclerosis, and chronic fatigue syndrome. [12]

Considerable health resources have been expended on tackling acute covid infections. The successful vaccination roll-out in the UK and internationally promises to reduce acute infection, disease severity, and transmission. The same investment is needed to better understand long covid, and for clinical services to develop long term treatments.

MS Chong, The National Hospital for Neurology and Neurosurgery London Queen Square and Cleveland Street

Ashish Shetty, The National Hospital for Neurology and Neurosurgery London Queen Square and Cleveland Street and University College London NHS Foundation Trust

Shane Delamont, Kings College Hospital London

Mayur Bodani, Kent and Medway NHS and Social Care Partnership Trust and School of Psychology, University of Kent, Canterbury

Peter Phiri, Research & Development Department, Southern Health NHS Foundation Trust and Primary Care, Population Sciences and Medical Education, Faculty of Medicine, University of Southampton

Gayathri Delanerolle, University of Oxford, Oxford

Acknowledgements: This paper is part of the multifaceted EPIC project that is sponsored by Southern Health NHS Foundation Trust and in collaboration with the University of Oxford.

Competing interests: PP has received research grant from Novo Nordisk, and other, educational from Queen Mary University of London, other from John Wiley & Sons, other from Otsuka, outside the submitted work. GD has received funding from the NIHR.All other authors report no conflict of interests for this article.

The views expressed are those of the authors and not necessarily those of the NHS, the National Institute for Health Research, the Department of Health and Social Care or the academic institutions.

References:

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Clinical neuroscience and long covid - The BMJ - The BMJ

Music, Math and Mind: The Physics and Neuroscience of Music (David Sulzer) – Limelight

David Sulzer is the Karl Kruszelnicki music nerds have been looking for. I just wish hed used a catchier title for his book. Because far from being a scientific treatise on the physics and neuroscience of music, Music, Math and Mind is a hugely entertaining, easy-to-understand account of how music works and why it has such an effect on us.

Not only that. Yes, Sulzer is a neuroscientist and currently professor of Psychiatry, Neurology, Pharmacology at the School of the Arts, Columbia University. But hes also an experienced composer, performer and recording artist across several genres, from classical to alt-rock. Just google The Krotopkins or Soldier String Quartet.

Sulzer clearly explains acoustics, musical notation, composition, the physiology of the ear and many other aspects essential to his subject, across time and cultures and using real-world examples. He also offers plenty of exercises and suggestions for listening, again mixing up the genres. After all, there is no room for prejudice or elitism in science. Nor should there be in music.

The maths in each chapter is usually separated out in sidebars with provocative questions like How much does sound weigh? along with fun facts about the length of organ pipes and the worlds most unwanted orchestra. But Sulzers main concern is integration: science and art are two sides of the same coin, and facts are nothing without imagination.

I loved reading about the reconstruction of the c.35,000-year-old Geissneklosterle flute and the Thai Elephant Orchestra. How our solfeggio note names derive from the hymn Ut Queant Laxis by Guido of Arrezzo, inventor of the musical staff for notation. Why equal temperament doesnt work in Indian classical music (try it). And how calcium influx triggers synaptic vesicle fusion. (!)

Frankly, and notwithstanding Sulzers admission that no one needs this book, no musical home or institution should be without Music, Math and Mind.

Music, Math and Mind: The Physics and Neuroscience of MusicBy David SulzerColumbia University Press, PB, 304pp, $46.95ISBN 9780231193795

Available from Booktopia.

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Music, Math and Mind: The Physics and Neuroscience of Music (David Sulzer) - Limelight