Category Archives: Organic Chemistry

Organic Chemistry

Science-First Skincare Company Michal Morrison Secures Exclusive World-Wide License of Proprietary STEM6 Molecule, Supported by Over 25 Years of…

AUSTIN, Texas, May 4, 2023 /PRNewswire/ -- Science-first skincare companyMichal Morrison Inc., has officially received an exclusive world-wide license to use the revolutionary STEM6 molecular technology in skincare.

Michal Morrison

STEM6, a new superpower metamolecule , marks a new era of biomimetic skincare. A scientific breakthrough in the beauty industry, STEM6 is a new composition of matter that supports the skin's stem cell signaling pathway to awaken the millions of cells responsible for healthy-looking skin. As a result, skin is healthier, more radiant, and visibly rejuvenated.

Based on 25 years of stem cell science, the exclusive STEM6 technology was discovered by Dr. Fuqiang Ruan, an innovative scientist with a doctorate in Synthetic Organic Chemistry, and stem cell scientist Dr. Michael Kahn, Professor of Cancer Biology and Molecular Medicine at the Beckman Research Institute, City of Hope. Michal Morrison Inc. was founded by Austin-based entrepreneur Michal Ann Morrison. Michal's passion for a 'science first approach to skincare' became her inspiration to create a product with novel technology and unparalleled efficacy.

Genesis Molecular Technologies Inc., an affiliate organization of Michal Morrison Inc, received the notice of allowance (NOA) from the United States Patent and Trademark Office on March 7, 2023. The patent relates generally to modulation of the Wnt/-catenin pathway in mammalian cells and tissues, and more particularly to novel CREB binding protein (CBP)/-catenin inhibitors and the cosmetic, and therapeutic uses thereof (e.g., in dermatological applications for skin, hair and nails), and methods of making the disclosed exemplary compounds.

Michal Morrison's inaugural hero product, Genesis STEM6 Molecular Serum, is the first and only bioserum with the patented STEM6 molecule. This molecular superpower uses your biology's inherent potential to extend cell longevity for healthier-looking skin.

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The STEM6 molecule is exclusively available in Michal Morrison products. Genesis STEM6 Molecular Serum is available in a premium recyclable glass bottle onMichalMorrison.com for $175, or for $140 through a two-month subscription program.

For additional information and interview requests please contact:Creative Media Marketing at michalmorrison@cmmpr.com

ABOUT MICHAL MORRISON, INC.: Michal Morrison, Inc. is a science-first skincare company established in stem cell science and supported by its novel STEM6 molecular technology. Founded by Michal Morrison in 2022, the company will premiere the first and only bioserum with the STEM6 molecule - Genesis STEM6Molecular Serum. Michal Morrison products are available online atwww.michalmorrison.com.

Michal Morrison

Cision

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Science-First Skincare Company Michal Morrison Secures Exclusive World-Wide License of Proprietary STEM6 Molecule, Supported by Over 25 Years of...

Organic Chemistry

Tetrahydrocanniboic Acid (THCA): Legal Until You Heat It, Maybe – American Council on Science and Health

Nowhere is the silliness of our drug laws more evident than in the case oftetrahydrocannabinolicacid (THCA). The chemical, one of about a dozen found in hemp and marijuana, has no psychotropic activity, so it's legal, right?

Yes. Also no. And maybe. Hope that was helpful.

These are all correct, thanks to the tortuous, often conflicting, labyrinth of arbitrary laws that make up the mess that is called (but maybe not with a straight face) our "drug policy." There really isn't any semblance of policy regulating marijuana products. It's more like a dart board with the numbers missing, something I'll be writing about at a later date. Here's a tease.

Yeah, thisreally clears things up. Source: VIAA Hemp

THC

THC is short for delta-9-tetrahydrocannabinol, the primary intoxicant of cannabis. It remains classified as Schedule I by the geniuses at the DEA, the same category as heroin and illicit fentanyl. [Emphasis mine]

Schedule I drugs, substances, or chemicals are defined as drugs with no currently accepted medical use and a high potential for abuse. Some examples of Schedule I drugs are: heroin, lysergic acid diethylamide (LSD), marijuana (cannabis), 3,4-methylenedioxymethamphetamine (ecstasy), methaqualone, and peyote.

Source: DEA Drug Scheduling

Seriously? Marijuana is in the same category as heroin? In what universe does this make sense?

Since state laws are all over the place I'm not going to try to make "sense" of them but feel free to do so yourself...

Source: National Conference of State Legislatures.As of April 2023

THCA(Tetrahydrocannabinolic acid)

Rather than getting bogged down in that mess, I'm going to discuss one cannabis component that is of particular interest:Tetrahydrocannabinolic acid. Why is it interesting? Three reasons:

"[A]controlled substance analogue is a substance which is intended for human consumption and is structurally or pharmacologically substantially similar to or is represented as being similar to a Schedule I or Schedule II substance.."

Source: DEA Drug Scheduling

Be forewarned. It's time for...

Decarboxylation of-ketoacids(masochists only, please)

Usually, when you heat things, including most chemicals,they just get hot. But not in this case.

Decarboxylation oftetrahydrocanniboicacid forms 9-delta-THC

When THCA is heated, for example in hell, the carboxylic acid (yellow arrow), breaks down, losingCO2, andleaving in its place a hydrogen atom. This is a well-known reaction in organic chemistry, which is called thedecarboxylation of a-ketoacid a fact that will be thoroughlyuseless in your life, no matter how long you live. Here's the standard example:

OK, that's just peachy, but if you look at the structure of THCAthere isn't any -keto acid, right? So how can heating the damn stuff make it turn into THC??

Just another reason why people hate organic chemistry

Organic chemistry is simply a set of rules. Once you learn them you've got it down, right? No. Not right. This is because there are rules about rules, some of which are obvious. Many are not. Here's one that isn't.

But before you look, please remove the following items from your home so you won't be tempted to use them.

Don't say I didn't warn you.For crazy bastardsanyonewho made it this far...

Phenol (left) can exist in two forms interchangeable forms.Theenol form (left) predominates, but there is also a teensy bit ofketo form (left) in there too, which just happens to be a -keto acid. This explains why THCAcan undergo decarboxylation when heated.

THCA in its enol and keto forms. Note that the keto form is a poorly-disguised beta-keto acid, which means that it loses carbon dioxide upon heating. It does, giving the keto form of THC, which immediately rearranges to THC.

This mercifully ends The Dreaded Chemistry Lesson From Hell. I doubt many of you are mourning this development, but don't blame me. You asked. (1)

It might be time to break out the THCA. Just remember to heat it.

NOTE:

1) I'm not kidding. I do get requests from more than a few people to do these wretched articles. No accounting for taste. After all, some people love kale.

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Tetrahydrocanniboic Acid (THCA): Legal Until You Heat It, Maybe - American Council on Science and Health

Organic Chemistry

Fast evaluation of the adsorption energy of organic molecules on … – Nature.com

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Fast evaluation of the adsorption energy of organic molecules on ... - Nature.com

Organic Chemistry

UArizona will recognize seven outstanding graduating seniors at … – University of Arizona News

University Communications

Today

Seven graduating University of Arizona seniors will be honored during Commencement for their extraordinary accomplishments in the classroom and beyond.

The university's 159th Commencement ceremony will be held at Arizona Stadium on Friday, May 12, at 7:30 p.m. A full schedule and more information about this year's ceremony are available on the Commencement website.

Nominated by faculty and peers, this year's seven student award winners were selected based on their determination, notable achievements and positive contributions to their families and communities.

Ryan Ellsworth is graduating with a Bachelor of Arts in communication, with a minor in criminology. Originally from Aguadilla, Puerto Rico, Ellsworth received an associate degree in liberal arts from Pima Community College before attending UArizona.

Raised among military veterans, Ellsworth said he has always wanted to serve his country for a purpose greater than himself. He is deeply involved in the Air Force ROTC program, which helps students earn a degree and commission as officers in the Air Force. He also works full time for Campus Recreation. Thanks to his busy schedule, Ellsworth often wakes up at 4 a.m. for ROTC events, to complete schoolwork throughout the day, and go to work.

Ellsworth is a recipient of the Air Force In-College Scholarship and received Air Force ROTC honor and warrior awards. He also was named Cadet of the Semester in fall 2019.

Following graduation, Ellsworth will attend combat systems officer training in Pensacola, Florida, and intends to pursue a master's degree.

Jessica Plaza Rodrguez is graduating with a Bachelor of Science in family studies and human development and a Bachelor of Arts in Spanish with an emphasis in Hispanic literature. Originally from Mexico City, Plaza Rodrguez moved to Tucson five years ago to reunite with her family and find better opportunities.

As a first-generation student and immigrant, Plaza Rodrguez had to learn a new language and understand a new culture, and she faced other barriers when she arrived at the university. During her time at UArizona, she worked for the Immigrant Student Resource Center, helping fellow students with immigrant backgrounds navigate the university and developing communication strategies to ensure those who needed the center's services could find and access them. Plaza Rodrguez has interned for the Colibr Center for Human Rights, supporting a campaign called "Cuntos Ms?" that raised funds for DNA kits to help identify and honor those who have died trying to cross the U.S.-Mexico border.

Plaza Rodrguez now works at the YWCA as a program coordinator, helping facilitate programs and provide resources for people of Latin American descent. She is also a research assistant and translator for a project called AZHEALTHTXT, a bilingual health information-sharing platform led by the UArizona Center for Rural Health.

Plaza Rodrguez has been honored with several scholarships and awards, including a Wildcat Distinction Award and the Ruth Reed Cowden Scholarship. She was also named to the Dean's List with Distinction. After graduation, Plaza Rodrguez is interested in attending law school and becoming an immigration attorney.

Mikah Wesley Rosanova is graduating with a Bachelor of Arts in law, with minors in music and gender and women's studies. Rosanova, who uses the pronoun they, is from Flagstaff.

During their time at the University of Arizona, Rosanova has focused on helping and finding opportunities for students with marginalized backgrounds and identities. As a lead resident assistant, Rosanova encouraged first-year students to become engaged and invested in their well-being and advocated for LGBTQ+ residents, working with the UArizona LGBTQ+ Resource Center and Housing and Residential Life to improve programming, resources and education. As a PATH mentor, Rosanova supported first-year students in the W.A. Franke Honors College and contributed to the college's equity initiatives.

Rosanova completed several creative writing independent studies, as well as a first-year project focused on lived experience with hormone replacement therapy. Rosanova participated in the Undergraduate Research Opportunities Consortium's Summer Research Institute, working with Suzanne Dovi, a professor in the School of Government and Public Policy, to investigate the effects of transphobia and misogyny on research practices. Rosanova's honors thesis focuses on gender non-conforming communities and trans-competent research practices.

Rosanova was named to the Dean's List with Distinction and has received several awards, including the David G. Hastings B.A. in Law Scholarship, the Wildcat Distinction Award and Returning Resident Assistant of the Year. Following graduation, Rosanova plans to pursue a doctorate in political theory and gender studies, with plans to work with nonprofit organizations that support marginalized communities.

Kristijan Barnjak is graduating summa cum laude with a Bachelor of Arts in philosophy, politics, economics and law, a Bachelor of Arts in economics, and a Bachelor of Arts in philosophy with an emphasis in ethics. Barnjak was raised in Seaford, New York.

Barnjak found community at St. Thomas More Catholic Newman Center, on the university's campus, during his freshman year, and eventually became a student minister and served on the center's outreach committee. Barnjak joined the Daily Wildcat news desk in spring 2020 as a reporter covering the Associated Students of the University of Arizona and the university's efforts to mitigate COVID-19. He later served as news editor and copy editor and was appointed editor-in-chief during the fall 2022 semester. Barnjak has been a resident assistant at rbol de la Vida dorm since fall 2021. He became a lead resident assistant his senior year and was inducted into Rho Alpha Sigma, a national honorary for resident assistants.

Barnjak's honors thesis focused on state anti-boycott laws passed in reaction to boycotts of the firearm and energy companies as part of corporate environmental, social and governance initiatives.

Barnjak was awarded the Gerald J. Swanson Endowed Scholarship for Undergraduate Excellence in Economics his junior and senior years. He received the Ancient Greek Language Summer Scholarship from the Department of Religious Studies and Classics to study ancient Greek during summer 2021. Barnjak will attend law school following graduation and hopes to work as an antitrust attorney for the Department of Justice.

Hillary Schiff is graduating summa cum laude with honors with a Bachelor of Science in biochemistry and a Bachelor of Arts in French. She was born in Australia and grew up in Colorado Springs, Colorado.

Interested in a career in science, Schiff began researching allergic asthma drug development in the lab of Scott Boitano, a professor in the College of Medicine Tucson, in the spring of her first year. The work resulted in published research, on which Schiff was the lead author, and served as the basis of her honors thesis. Schiff also has a passion for mentorship and communication. During her sophomore year, she became a general chemistry preceptor as well as a Department of Chemistry and Biochemistry peer mentor. She also worked as a news reporter for the Daily Wildcat.

Schiff's decision to pursue medicine was shaped by her experiences volunteering in the Tucson community. Initially inspired by witnessing her grandmother's health struggles, she continues to see her grandmother in the patients she serves. Schiff spends her Sundays volunteering at the WORKship project at Z Mansion, an outreach program serving the local population experiencing homelessness. Through the Patient Experience Internship Program, part of the university's A Center, she also volunteered at Banner University Medical Center Tucson, working alongside health care professionals to ensure patient comfort.

Schiff is a recipient of the Galileo Circle Scholarship and was named to the Dean's List with Distinction. Following graduation, Schiff will pursue a medical degree at the University of Chicago Pritzker School of Medicine.

Vanessa Addison is graduating summa cum laude with a Bachelor of Science in biochemistry. She is passionate about biomedical science and health education and wants to spend her career increasing health literacy and providing aid to medically underserved communities.

Driven by her love for science and service, Addison interned as a first-year student with the Fight4HER campaign to advocate on Capitol Hill for affordable health. She volunteers regularly at the Sister Jose Women's Homeless Shelter and started a social media campaign to raise awareness about the homeless crisis in Tucson. Throughout the COVID-19 pandemic, Addison served as an EMT to help vaccinate students and Tucson residents. She also worked in an addiction rehabilitation clinic.

In 2021, Addison began researching in the lab of Ross Buchan, associate professor of molecular and cellular biology. Her efforts to understand the molecular mechanisms underpinning amyotrophic lateral sclerosis served as the basis of her honors thesis, several award-winning posters, two research grants and contributions to a scientific publication. She is committed to enhancing inclusivity in science, technology, engineering and math and has served as a preceptor, Department of Chemistry and Biochemistry ambassador, peer mentor, organic chemistry tutor and a tutor at the university's SALT Center.

Addison is the 2023 Department of Chemistry and Biochemistry Outstanding Senior and has been honored with the Ronald Gonzalez Wildcat Spirit Award, Michael A. Wells Scholarship, Arizona Distinction Award, Highest Academic Distinction, Warner Scholarship, Black and Kletz Scholarship, and a Franke Honors Research Endowment. She was crowned the 2022 Homecoming queen. Addison will attend medical school in the fall.

Elizabeth Grace Hala'ufia is graduating summa cum laude with honors with a Bachelor of Science in neuroscience and cognitive science and a minor in biochemistry. Born in Marana, Hala'ufia is a track and field student-athlete.

Hala'ufia is a 2019 alumna of the UArizona BIO5 Institute KEYS Summer Research Program, which gives high school students opportunities to work in labs with university bioscience researchers. Working alongside Daniela Zarnescu, a former UArizona faculty member who studies neurodegeneration, Hala'ufia contributed to research on modeling dementia-relevant phenotypes in fruit flies. Hala'ufia also spent a summer at Johns Hopkins University testing several viruses' abilities to treat autism spectrum disorder. She now works in the lab of Arthur Riegel, an associate professor of pharmacology.

Hala'ufia has also worked as supplemental instruction leader in organic chemistry and physics as part of the THINK TANK's Supplemental Instruction program, which lets students help their peers in difficult courses. She has also offered been a preceptor for biochemistry and neurophysiology courses.

Hala'ufia has received the Marana Unified School District 2340 Scholarship, Wildcat Distinction Award, Vivien Thomas Scholars Initiative Fellowship, Maximizing Access to Research Careers Training Award and Pac-12 All-Academic Honors. Hala'ufia will pursue a doctorate in neuroscience at Johns Hopkins University, with the goal of conducting neurological disease research that leads to life-saving therapies.

Link:

UArizona will recognize seven outstanding graduating seniors at ... - University of Arizona News

Organic Chemistry

Bemidji State’s Matthew Fabian reflects on challenges, changes … – The Bemidji Pioneer

BEMIDJI No matter what happens in his life, Matthew Fabian is able to count his blessings.

Throughout seemingly impossible circumstances over the past three years, Fabian has never lost sight of his goals and on May 5, will accept his diploma from Bemidji State University having majored in chemistry.

This comes after he earned his degree in biochemistry, cellular and molecular biology last spring with summa cum laude honors.

After graduation, he plans to make time for the simple things many people may take for granted.

As of right now, my summer plans are to start driving again, do some fishing, decompress and figure out the path and direction that I can be the most productive in, Fabian said.

Fabian came to BSU in 2018 after graduating from Pequot Lakes High School.

He had an initial interest in becoming a doctor, though his aspirations started changing at the tail end of his sophomore year at BSU. Fabian started developing headaches in mid-March 2020 right as the coronavirus pandemic took hold of the world.

It was about the time when all of the universities shut down and everybody had to move back home because of COVID, Fabian recalled. I thought at first (the headaches) were because of stress, moving back and transitioning to online classes. Finals happened and I thought, Well, thats just normal. Everybodys stressed during finals. But they kept getting worse and worse.

The headaches continued through July 2020 when Fabian started developing nausea. His mother brought him to the emergency room a week before he was meant to start classes for the fall 2020 semester and underwent a CT scan.

Fabian noted that as a baby, he had sagittal craniosynostosis, a condition that affects the skull.

There have been reports of people who were my age that had surgery as a baby to correct (the condition) having recurring head pain many years after the fact, he said.

However, nobody expected the CT scan results that would seemingly change the trajectory of Fabians college experience and life in general.

After the scan, the doctor came back into the room with big eyes saying the helicopter would be there in 15 minutes to bring me to St. Cloud as I had a mass on my brain stem and fourth ventricle.

Because of COVID restrictions, nobody could accompany Fabian to St. Cloud. I was airlifted for surgery that night without my parents, Fabian added.

Once in St. Cloud, doctors successfully removed Fabians brain tumor. However, he would experience a stroke the day after this surgery.

The surgery was a success, but from that, I suffered a stroke. Among other things, the stroke took away the ability for me to move my right side, swallow and I developed double vision, Fabian explained.

Around this time, doctors inserted an external ventricular drain to relieve pressure in hopes his brain could start absorbing fluids on its own. Days later, he would develop double-lunged pneumonia.

Fabian was soon on the rebound, however, as he rehabilitated in the hospital over the following three weeks. He started relearning how to walk around the time he was sent to Mayo Clinic to begin seven weeks of radiation treatment followed by six months of chemotherapy.

Because of changes in the MRIs and fear of relapse, I was scanned monthly for seven months, Fabian explained. Many scares, but all were determined to be markings from surgery and treatment.

Fabian earned the OK to return to BSU after he completed chemotherapy in April 2021. His return came with its own set of challenges as he recovered from the side effects of his treatments.

As the school year started, I had major chemo fog, fatigue and hearing loss from the chemo and processing, retention and learning struggles from brain trauma due to surgery, the stroke and treatment, he said. (It was) a very tough year with parts I dont even really remember.

With the support of BSUs biology and chemistry departments, however, Fabians return was a little bit easier to navigate.

They have gone over and above in helping me and understanding some of my struggles, even allowing me to take Zoom appointments with Mayo oncology doctors in their offices during school days, he added.

Fabian is currently scanned every three months and will remain on that schedule for the next couple of years. He will continue to be monitored throughout his life with check-ins from various doctors.

While it hasnt been easy, Fabian has remained active in campus life and demonstrated that he is more than whats happened to him.

He aided the BSU Trap Club during its inaugural invitational trap shoot in 2018 by shooting a 98 out of 100 in his first event, helping the club to secure its win against three other collegiate teams.

Fabian found success in a national trap shooting tournament in high school, as well.

As a team, our high school finished 19th in the nation, he detailed. As an individual, I finished in the top 400 in the nation.

Because of inner ear damage, he is unable to shoot but has been fulfilling a role with the club to ramp up its operations this past semester and potentially host tournaments once fall comes around.

Fabian is currently undecided in terms of a future career but has an interest in volunteering at his high school this summer. He was a teachers assistant for organic chemistry and anatomy and physiology classes at BSU, leading him to consider the teaching field as a potential career path.

He also builds fishing poles, a pastime he picked up from his dad who used to be a fishing guide.

In high school, I did that a little bit. When I was recovering, I couldnt do a whole lot else, Fabian said, so I really got into it then. Its really cool to catch a fish with a rod that you made.

With the summer to look forward to, he continues to navigate his new normal.

There are a lot of things that are different now, but slowly, Ive been learning to adapt and to do things differently, Fabian left off, to make things easier based on the new me.

Bemidji State will hold three graduation ceremonies at the Sanford Center on Friday, May 5, one for each college. Each ceremony is also available via livestream on BSU's social media pages.

A ceremony for the College of Arts, Education and Humanities will take place at 9 a.m. Graduates from the College of Business, Mathematics and Science will be recognized at noon. The College of Individual and Community Health will have its ceremony at 3 p.m.

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Organic Chemistry

Mithra and the University of Lige Secure Proof-of-Concept for Novel Manufacturing Process of Estetrol – Yahoo Finance UK

Mithra Pharmaceuticals

Collaboration demonstrates Mithras commitment to innovation and sustainable drug supply in Womens Health

Liege, Belgium, 04 May 2023 7:30 CEST Mithra (Euronext Brussels: MITRA), a company dedicated to Womens Health, today announces that through a collaboration with researchers from the University of Liges Center for Integrated Technology and Organic Synthesis (CiTOS), proof-of-concept has been demonstrated for a novel manufacturing process of a key estetrol intermediate.

Estetrol (E4), Mithras core asset, is a natural estrogen with potential applications across multiple therapeutic fields including Womens Health (contraception and menopause). After successfully launching the first estetrol-based product in 2021, the contraceptive pill Estelle, Mithra continued to work towards innovation in manufacturing aimed at reducing cost of goods and potential environmental impact through the removal of a metal catalyst in the production process.

The Mithra and CiTOS teams have developed a novel, intensified manufacturing methodology to improve robustness and productivity while ensuring a limited environmental footprint. The new metal-free process is based on the thermolysis of a key sulfoxide derivative of estrone. Early proof of concept for this novel methodology was published in the peer-reviewed industry journal Reaction Chemistry & Engineering earlier this year here.

Mithra and CiTOS will continue their development work, with initial commercial production by a CDMO using the enhanced manufacturing process expected in 2026/27.

David H Solomon, Chief Executive Officer of Mithra, commented: Mithras collaboration with CiTOS demonstrates our commitment to innovation and sustainable drug supply in womens health. With the mass production of estetrol integral to our daily activities, we are always looking at ways we can enhance the manufacturing process. This particular method allows us to produce estetrol at scale to meet increased demand while also delivering reduced cost of goods.

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Jean-Christophe Monbaliu, Professor of Organic Chemistry at the University of Lige, added: With this novel methodology we are able to yield about 1kg of the estetrol intermediate every three hours in just our pilot setup. If we applied these metrics to an industrial estetrol production setup, a forecast of several tons is achievable with minimal global footprint.

********

For more information, please contact:

Investor relations : investorrelations@mithra.com

About Mithra

Mithra (Euronext: MITRA) is a Belgian biotech company dedicated to transforming Womens Health by offering new choices through innovation, with a particular focus on contraception and menopause. Mithras goal is to develop products offering better efficacy, safety and convenience, meeting womens needs throughout their life span. Mithra explores the potential of the unique native estrogen estetrol in a wide range of applications in women health and beyond. After having successfully launched the first estetrol-based product in 2021, the contraceptive pill Estelle, Mithra is now focusing on its second product Donesta, the next-generation hormone therapy. Mithra also offers partners a complete spectrum of solutions from early drug development, clinical batches and commercial manufacturing of complex polymeric products (vaginal ring, implants) and complex liquid injectables and biologicals (vials, pre-filled syringes or cartridges) at its technological platform Mithra CDMO. Active in more than 100 countries around the world, Mithra has an approximate headcount of 230 staff members and is headquartered in Lige, Belgium. http://www.mithra.com

ESTELLE, DONESTA and MYRING are registered trademarks of Mithra Pharmaceuticals or one of its affiliates.

Important information

The contents of this announcement include statements that are, or may be deemed to be, "forward-looking statements". These forward-looking statements can be identified by the use of forward-looking terminology, including the words "believes", "estimates," "anticipates", "expects", "intends", "may", "will", "plans", "continue", "ongoing", "potential", "predict", "project", "target", "seek" or "should", and include statements the Company makes concerning the intended results of its strategy. By their nature, forward-looking statements involve risks and uncertainties and readers are cautioned that any such forward-looking statements are not guarantees of future performance. The Company's actual results may differ materially from those predicted by the forward-looking statements. The Company undertakes no obligation to publicly update or revise forward-looking statements, except as may be required by law.

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Mithra and the University of Lige Secure Proof-of-Concept for Novel Manufacturing Process of Estetrol - Yahoo Finance UK

Organic Chemistry

Day in the Life of an Engineering Manager: Sahara Becker – All … – Society of Women Engineers

I graduated in 2018 from Rensselaer Polytechnic Institute with a BS degree in Chemical Engineering. I really loved my chemistry and organic chemistry classes in high school which prompted me to study chemical engineering in college. My path to my current role is not traditional. Throughout my college experience, I had multiple internships in the chemical industry, but after graduation, I instead took a job as a software engineer, which eventually led me to become the security operations manager for my company.

In college I was a part of the Society of Women Engineers and the outreach coordinator for my RPI SWE section. SWE gave me a lot of leadership opportunities that I did not have through my general coursework in college. It also provided me with a network of women going through similar experiences as myself being a minority in our classes. I am now able to leverage this network to help find jobs and I have a community to return to every year at our annual conference.

In college, I had five internships and did research on campus. While most of my college experiences were in the chemical industry as opposed to software development or cybersecurity, I still learned a lot about myself, which led me to where I am now. I did several internships at SABIC, at a location that manufactures plastic, one internship at GE in rural Tennessee where they manufactured busway (an alternative to wire for conducting electricity), and one internship at ExxonMobil with the environmental remediation team at their headquarters. I went into each of these experiences not knowing what to expect and I had to move all over the country for them. I went in with an open mind and I learned that I am a calculated risk taker and that sometimes the best opportunities and projects are the ones you dont plan for yourself. I also learned that real world experiences will never be like the textbook problems I encountered in my classes. Instead, the most valuable thing that contributes to success is being open to learning new things and the creative mindset I use when approaching problems.

In one particularly shaping experience at SABIC, I was tasked with managing the scheduling of projects for a large plant shutdown (many maintenance tasks and projects cant be done while the plastic manufacturing lines are up and running). This was a large responsibility and through that assignment, I gained experience managing contractors. I knew after that assignment that I wanted to manage a team one day. All these experiences led me to take the risk and switch career fields after I graduated when I was offered a position as a software engineer. Despite not knowing much about software, I knew I could learn and I knew that I had the right mindset to approach any problem I encountered in that new field.

I knew that I wanted to be an engineering manager because I knew that the visions and aspirations I had for making change at a company exceeded my ability to complete individually. I knew that I would need a team to help me and that I would need to delegate tasks in order to maximize my contributions. In my internships and my role as an engineer at McMaster-Carr, I had the opportunity to manage contractors for the projects I worked on. This gave me leadership experience that helped me successfully transition into management. While working at McMaster-Carr I got an MBA and a Masters degree in Information Technology Management part time from Indiana Universitys Kelley School of Business. I was promoted into management while I was in the middle of the MBA program.

Currently, I am the cybersecurity operations manager at McMaster-Carr. I manage a team of engineers that work to make sure our companys computing environment is secure and protected against cyberattacks. We remediate vulnerabilities (flaws in software or hardware that can potentially allow an attacker to get into our systems) and we investigate potential attacks. On a typical workday, I am having check-ins with my engineers to make sure I am up to date on their assignments. I am also communicating to other software development and infrastructure teams at the company to ask for their assistance in remediating vulnerabilities that affect their systems. As a manager, I am also responsible for communicating the benefits and progress of my team to the broader company so I am often meeting with my boss and others in leadership to share the impact of our work.

Prior to becoming the security manager, I had several engineering roles on various software development and infrastructure projects and then I became the tech support manager for our California branch. Through each of these experiences, I learned new things about technology that have been useful to me as I continue my career. The tech support manager role was particularly shaping for me as it was my first experience as a manager. In that role, I managed a call center and email queue with on-site cases as well as remote support cases. We supported a wide variety of software and hardware so I had to learn how to use my network within the company to help solve the tough problems. I also learned to communicate with a broad variety of teams as our tech support organization serves our warehouses and corporate teams.

My company, McMaster-Carr, is an industrial supply company that aims to be the complete source for any industrial need. We sell over 500,000 products and we are best known for our massive yellow and green catalog that engineers love to peruse so they can discover new things that help them solve whatever problem theyre working on. Check out this video Mythbusters Adam Savage made about our catalog: https://youtu.be/8kbu34dk92s McMaster-Carr is unique in that we often hire based on capability to learn and not current skill. We value teaching and learning and have a training program that helps new employees get quickly up to speed with technology and coding. Thats how I was hired with a background in chemical engineering for a job in software engineering. So many of the lead engineers at my company that I look up to have backgrounds in non-technical fields like Economics, English, and Philosophy. This allows us to have a variety of perspectives on each of our projects so we can come up with creative solutions.

My favorite part of being an engineering manager is helping my team achieve their fullest potential. I like to understand each persons professional and personal goals and help them work toward them. When a person is feeling valued and supported by their manager, they do better work, and that is good for both them and the company.

If I can give any student some advice it would be to not let anyone tell you that you cant achieve your goals and know that the ability to learn is a superpower that will propel you in your career. If you are unsure what type of engineering you want to pursue, dont worry, you can always pivot from the choice you make. The most valuable thing you get out of an engineering degree is the problem solving mindset and that is transferable to any job!

Written by Emily Tacopina: Emily is a Consultant Engineer at FM Global. Emily graduated from the University of Rhode Island with a BS degree in Mechanical Engineering.

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Organic Chemistry

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Organic Chemistry

Job shadowing steered ASU outstanding grad to dentistry – ASU News Now

May 3, 2023

Editors note:This story is part of a series of profiles of notablespring2023 graduates.

With a love of working with people and a passion for human anatomy, Arizona State University College of Integrative Sciences and Arts Class of 2023 Outstanding Undergraduate Spencer Bigler said he first thought his future path would be going to medical school, to be either an anesthesiologist or a surgeon. Accepted to every dental program he applied to, Spencer Bigler will attend Midwestern University in Arizona on a military scholarship with the U.S. Navy, then do an oral and maxillofacial surgery residency at a naval hospital before serving his country as a Navy dental surgeon. Download Full Image

But that shifted the summer between his freshman and sophomore years, when he started shadowing anesthesiologists and orthopedic surgeons.

I realized that the anesthesiologist did not do enough hands-on work for me, and the orthopedic surgeon was working 80 hours a week, making it hard for the family, said Bigler, who majored in applied biological sciences at ASU Polytechnic campus and was married at age 20 to Livi Bigler, a College of Integrative Sciences and Arts psychology major. I started second-guessing school and wondered if I should change careers altogether.

About this same time he was asked to help out during the COVID-19 lockdown at an office of general dentistry.

I didnt have much experience, but they were understaffed and being overrun by emergency appointments, he said. I noticed that many of the more complicated cases such as jaw fractures, complex sleep apnea issues and patients who had received radiation were all sent to a specialist known as an oral and maxillofacial surgeon. After looking into the field, I found out that they are trained in both dentistry and medicine, as they perform surgeries and administer general anesthesia. I decided to follow one surgeon, and when I found out he worked less than 40 hours a week and had a happy family life, I knew this was the career for me, and I have never looked back.

Bigler, who is graduating with a GPA above 4.0, has worked at a dental clinic and had many other applied dental experiences, including a weeklong dental mission trip in Mexico, from his sophomore year onward. He also has set the paperwork in motion to found a nonprofit in the Dominican Republic that provides opportunities to exchange community service work, like cleaning up streets and beaches, for health care services. Bigler was awarded funds from ASUs J. Orin Edson Entrepreneurship + Innovation Institutes pitch competition to support the organization.

This semester I interned at Arizona Maxillofacial Surgeons, where I work with some great oral and maxillofacial surgeons, he said, and Ive learned many techniques that will help me out in the future.

To round out his dental school applications and solidify his knowledge, Bigler served as a supplemental instruction leader for Chemistry 116 and continues to tutor students in chemistry and organic chemistry. He was president of the Pre-Dental Club at ASU Polytechnic campus and a volunteer with the CISA Student Ambassador program.

Still, Bigler knew that getting accepted to a great school would also rest on his ability to do well on the Dental Admission Test.

I took the exam between my junior and senior year. The five-hour test covers topics taught throughout undergrad and other topics that I had to learn outside of my school studies, he explained.

After six months of studying and practicing with other ASU pre-dental students, I took the test, hoping to get a good enough score to be competitive, Bigler said. I was shocked when I found out I scored in the 99thpercentile. I was ecstatic and knew that my dreams of becoming an oral and maxillofacial surgeon could indeed become a reality."

Indeed, he was admitted into all of his top picks for dental school.

Bigler didnt just rest on his incredible accomplishments. He is sharing his experiences to try to lift others up, explained Julie Lim, College of Integrative Arts and Sciences assistant director for student engagement.

Spencers innate desire to help others includes helping his peers here at ASU, said Lim, who coordinates theCISA Student Ambassador program and connects with many student club leaders. As president of the Pre-Dental Club, Spencer is teaching his peers about the dental field and supporting their goals of getting into dental school. Once others learned of Spencers DAT scores and admission into dental programs, he was inundated with questions and requests for tips and advice. To help as many interested individuals as possible, Spencer created a resource to address these questions.

His comprehensive guide, How to Get into Dental School from Start to Finish, is free to the public to help preprofessionals get access to the tools they need to get into dentistry. It even includes some tips that are specific to ASU students.

Bigler plans to turn it into a website by fall. I was lucky enough to have a ton of social capital around me as I prepared for dental school, he noted in the guide, and I want to make that knowledge public for anyone who is searching to have access, without having to pay any fees to get that knowledge.

Spencer has continued to amaze me as he takes steps to not only reach his goals but is also focused in how service can be tied along with his career path, added Lim. During my interactions with students, most plan and think about what they want to do in the future. Spencer, on the other hand, is doing it now.

Bigler shared these additional reflections about his ASU journey and plans for the future.

Question: Whats something you learned while at ASU in the classroom or otherwise that surprised you or changed your perspective?

Answer: ASU taught me the importance of social capital and how not everyone has equal amounts of it. Social capital is the predisposition that some people have to succeed due to their networks and social circles that can help them get where they want to get. Unfortunately, many people are born into social circles that make it hard for them to succeed, not because they are not smart enough or unwilling to work, but because they do not know where to look or who can help them. ASU taught me to not only be aware of social capital, but also contribute to society by helping spread knowledge and social capital to the general public.

Q: Why did you choose ASU?

A: Living in the Dominican Republic at the time, I had applied to three colleges for undergrad a month before classes started. The first college to reach out to me to say I was accepted was ASU, two weeks before classes started. I knew I didnt want to wait a semester to start college, so I decided that I would go to ASU. Looking back, it was one of the best decisions I have made.

Q: Which professor taught you the most important lesson while at ASU and what was it?

A: I had several professors teach me profound lessons while here at ASU. One that sticks out to me was a lesson taught by Professor Vikas Garg, who teaches organic chemistry at the Polytechnic campus. He and Ihad formed a good professor-student relationship, as I was his TA, and he helped me study for the Dental Admission Test from time to time. After class one day, we got talking about cultures and how American culture differs from the culture in India where he is from. He knew that I was independent form my parents and married by the age of 20. He told me that he thought the American culture of becoming independent at a young age has proven to be a strong driving force in the success of young American leaders. At the time I felt overwhelmed juggling school, work, family life and future career plans, so hearing a professor giving me inspiration that all my hard work was making me a better person was both comforting and eye-opening.

Q: Whats the best piece of advice youd give to those still in school?

A: Be a creator of your circumstances, not a creature. This quote was given to me as I was learning Spanish in the Dominican Republic. I kept blaming the dialect and other people for my not being able to understand and speak Spanish fluently. After hearing this quote, I realized that the power was in me to take control of my circumstances and create something good out of it.

While working at Arizona Maxillofacial Surgeons, I heard a different quote that had similar meaning behind it. When an assistant stated that there was a problem with one of the autoclaves, the surgeon responded in a calm but firm voice, Be a part of the solution, not the problem. The assistant right away understood, and rephrased the statement to say, There is a leak in the autoclave, and it appears to be the seal; may I order a new seal? This was a live examplefor me of someone who started by being a creature of their circumstance by posing a problem, then corrected themselves and became a creator of their circumstance by posing a solution. We all have the power to do this in our everyday lives. Do it and it will change the way you see the world.

Q: What was your favorite spot on campus, whether for studying, meeting friends or just thinking about life?

A: I loved going to the library and borrowing markers to use on the whiteboards. I cant count how many exciting and engaging study sessions I had with fellow Sun Devils working up problems, and making fun ways to remember topics around the whiteboards in the library.

Q: What are your plans aftergraduation?

A: Ive accepted admission to dental school at Midwestern University in Arizona on a full-ride military scholarship with the U.S. Navy. I will get my four-year education there and then plan to do an oral and maxillofacial surgery residency at a naval hospital for another four years. Then I plan to serve my country as a surgeon in the Navy for a few years before settling down and working in a private practice. While on this journey I plan to start a family with my amazing wife, Livi; invest in real estate; and participate in dental humanitarian work.

Q: If someone gave you$40millionto solve one problem on our planet, what would you tackle?

A: Last summer I went back to the Dominican Republic and noticed a need for better access to health care, as well as cleaner streets and beaches. That inspired me to start a nonprofit organization known as MATA (Making A Thriving Atmosphere). Its goal is to make a thriving atmosphere for professionals and patients by helping them get access to what they need in exchange for service. Many Dominicans do not have the money to get the health care they want but have plenty of free time and are always in search of a job. MATA will find service opportunities that fit patients physical capabilities that they can do in exchange for treatment and access to health care.With $40 million I would be able to go further than I imagined by helping people in more countries than just the Dominican Republic, and reach out to other facets in health care outside of dentistry.

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Job shadowing steered ASU outstanding grad to dentistry - ASU News Now

Organic Chemistry

Upcycling method turns textile trash to functional coatings – Science Daily

In an effort to make textiles more sustainable, a new method allows researchers to break old clothing down chemically and reuse polyester compounds to create fire resistant, anti-bacterial or wrinkle-free coatings that could then be applied to clothes and fabrics.

The proof-of-principle study provides hope for unsustainable textile, apparel and footwear industries that together generate 20% of global solid waste. Many so-called recyclers end up illegally dumping textiles as trash in countries in Asia and Africa.

"We think that our clothes are recycled or reprocessed, but most of the time they are actually sent to other places as solid waste," said Juan Hinestroza, professor of fiber science and apparel design and director of the Textiles Nanotechnology Laboratory at Cornell University. "Our main goal is to offer a pathway to reuse this material."

The paper, "Upcycling of Dyed Polyester Fabrics into Copper-1, 4-Benzeedicarboxylate Metal-Organic Frameworks," published March 30 in the journal Industrial & Engineering Chemistry Research, describes the process of cutting textiles into pieces and chemically decomposing them into a soup of raw materials, dyes, additives, dirt and esters. A metal solution is added and building blocks from the polyester share an affinity with the metal, and selectively link together metal compounds forming tiny cages (called metal-organic frameworks) that settle to the bottom of the soup.

The cages that form are then used to make coatings, which may require minor structural tweaks to tailor each to specific uses. These might include coatings that make permanent press shirts that don't wrinkle, antibacterial surgical gowns or scrubs, or baby or industrial clothes that require a fire-retardant protection.

"One goal of my lab is to create a universal coating that will serve all these purposes, though we are still far away from that," Hinestroza said.

Yelin Ko, a doctoral student in the field of human centered design, is the paper's first author. Prior to this research, some believed the dyes and impurities in the mix would interfere with the process, but this proof-of-principle of the method -- known as controlled crystallization -- shows that the polyester-derived linkers can seek out and attach to metal compounds in solution, in spite of other present materials.

The research describes a closed loop process, where discarded materials may be reused and contribute to a circular economy -- a focus for many sustainability researchers at Cornell, Hinestroza said.

The study was partially funded by the National Science Foundation.

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Upcycling method turns textile trash to functional coatings - Science Daily