Category Archives: Pediatrics

Predicting Infection Risk in Childhood Cancer – News Center – Feinberg News Center

A statistical model can accurately predict the risk of bloodstream infections in a subset of children with cancer, according to a study published in the Journal of Clinical Oncology.

For children with cancer, fever is a common complication. While guidelines exist for managing fever in children with cancer who have very low white blood cell counts, no such guidelines exist for children with cancer without severely low levels.

Because of this, identifying patients with cancer and fever who are at a higher risk for bloodstream infections can be difficult, said Jenna Rossoff, MD, assistant professor of Pediatrics in the Division of Hematology, Oncology and Stem Cell Transplantation and a co-author of the study.

While some hospitals may choose to pre-emptively administer antibiotics to a feverish child being treated for cancer, that can lead to other complications such as antibiotic resistance later on, Rossoff said.

In the study, Rossoff and her collaborators sought to test a model developed to predict the risk of bloodstream infections, which can develop into sepsis, in feverish children with cancer.

This model has been designed to delineate bloodstream infection risk in these patients at presentation based on a variety of variables, and the overall goal is to reduce unnecessary antibiotic use and also identify patients obviously at high risk for a bloodstream infection, said Rossoff, who is also a member of the Robert H. Lurie Comprehensive Cancer Center of Northwestern University.

To test the model, investigators collected data on fever episodes occurring in pediatric cancer patients from 18 academic medical centers. They then compared the models predictions to the seven-day clinical outcomes in each of the 2,500+ cases and found that the model could accurately predict which patients were more likely to experience bloodstream infections, according to the study.

The findings suggest the model accurately identifies high-risk patients and could reduce unnecessary antibiotic use, Rossoff said.

Importantly, the paper showed that in the patients whose predicted risk for bloodstream infections using this model was low, there was a very low rate of true bloodstream infections, Rossoff said. For those few percent of patients who did have a bloodstream infection, there were no severe outcomes.

Moving forward, Rossoff said she would like to see more studies done testing the model in children with cancer who have undergone stem cell transplants and other novel therapies.

Fevers are a pretty frequent complication during treatment and when our kids dont need antibiotics, we should be avoiding them to prevent antibiotic resistance and disruption of the gut microbiome, she said. As much as we can safely safely being the key word decrease antibiotic administration, that would be a great thing overall.

The study was supported by the National Center for Research Resources Grant KL2TR000446.

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Predicting Infection Risk in Childhood Cancer - News Center - Feinberg News Center

Healing the divide: Advancing access to pediatric care – HealthLeaders Media

While a more privileged child may enjoy the luxury of prompt medical attention and preventive care, their counterpart in a poor area faces a labyrinth of obstacles hindering their access to essential healthcare services. Full story Share this: Tagged Under: healthcare access healthcare disparity pediatrics

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Healing the divide: Advancing access to pediatric care - HealthLeaders Media

McMaster Child Health Research Day charts the future of pediatric health – Brighter World

From left, researcher Briano Di Rezze, keynote speaker and Edmonton MP Mike Lake, chair of Pediatrics Angelo Mikrogianakis, McMaster Children's Hospital President Bruce Squires, pediatrics researcher Gita Wahi, Hamilton MP Lisa Hepfner, Offord Centre director Stelios Georgiades, and CanChild co-director Olaf Kraus de Camargo at this week's McMaster Child Health Research Day event.

BY Cheryl Crocker

March 28, 2024

More than 130 Health Sciences students, patient family members and special guests gathered to celebrate innovative research and compete for awards this week at the McMaster Child Health Research Day.

The March 27 event was developed in collaboration with Hamiltons child health community, including the Department of Pediatrics, the Offord Centre for Child Studies, CanChild, the Centre for Metabolism, Obesity and Diabetes Research, McMaster Childrens Hospital, and St. Josephs Healthcare Hamilton.

More than 125 studies were presented, spanning a significant breadth of topics, including artificial intelligence applications in health, basic science, chronic conditions and mental health interventions.

AI is not going anywhere, so we need to find ways to mitigate its effects, especially given the prevalence of online surveys and research, said third-year undergraduate student Samantha Rutherford, whose study explored ways to stop chatbots from interfering with online data collection a challenge she recognizes as universal across research fields.

Researcher Andrea Cross, an assistant professor in the department of Pediatrics, is leading an innovative education program to empower youth and families to engage in health research.

Many people who are graduating from the course are now becoming champions and leaders and embedding meaningful family engagement within their communities and organizations, Cross said.

The quality of research and students passion was impressive, said Hamilton Mountain MP Lisa Hepfner, who served as a guest judge.

McMaster shows once again it is at the forefront of health sciences and that it is invested in improving the lives of young people in Canada and around the world.

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McMaster Child Health Research Day charts the future of pediatric health - Brighter World

This is serious: The results of a measles outbreak have harmful outcomes – Contemporary Pediatrics

This is Serious: The results from a Measles outbreak have harmful outcomes | Image Credit: Prostock-studio - Prostock-studio - stock.adobe.com.

Homers philosophical quote, When it is out of sight, it is out of mind can be applied to the current measles outbreak in the United States and worldwide. Our patients and all pediatric providers need to know and respect the history of measles and remain steadfast in strongly recommending vaccination.

In 1912, measles became a nationally notifiable disease in the United States, which revealed approximately 6,000 measles-related deaths reported each year.1 Prior to 1963, it was estimated that 3 to 4 million individuals in the United States contracted measles annually and included the majority of children under 15 years old.1 The death rate was estimated to be between 400 and 500 people with approximately 1000 individuals experiencing the adverse outcome of measles encephalitis.1

In 1963, the first measles vaccine became available which significantly reduced the incidence and prevalence of measles outbreaks in the United States and later worldwide.2 Because of this, many individuals today have vaccine induced immunity to measles, and providers rarely have patients presenting with symptoms of measles. In fact, due to the vaccination program, measles was declared eliminated from the United States in 2000.1 However, since 2020, there have been measles outbreaks in various states in the United States. The article in Contemporary Pediatrics, by senior editor Joshua Fitch, Measles cases are reported in multiple states, discusses the current spread of measles in the United States.2

Out of sight, out of mind

With the success of the MMR vaccine, most parents no longer are aware of measles as a disease nor fear that their children will contract measles. However, this lack of knowledge results in parents being unaware of the potential harmful outcomes from contracting measles, including the adverse outcomes and even the potential for death in their unvaccinated children under the age of 5 years, as well as in children and adults who are immunocompromised. In addition, pediatric nurse practitioners and all pediatric providers need to know how to diagnose measles and to be aware of the possibility of children who contract measles developing a bacterial or viral superinfection, including but not limited to obstructive laryngitis, mastoiditis, hepatitis, encephalitis, and/or pneumonia.3

The MMR Vaccine Information Statement (VIS) given to parents and any individual at the time of vaccination, provides detailed information focusing on the vaccine itself, and includes brief paragraphs about measles, mumps, and rubella (MMR) diseases at the top of the VIS.4 Perhaps the VIS and providers need to emphasize the potential for adverse outcomes from contracting the disease especially for those parents who are questioning whether to have their child vaccinated or are vaccine hesitant or vaccine refusers.

Measles disease and death rates

Prior to the availability of the measles vaccine in 1963, the World Health Organization reported that major measles epidemics occurred every 2 to 3years resulting in 2.6 million deaths in each epidemic year.2 The MMR vaccine has reduced worldwide deaths to 128,000 in 2021.2 However, in my opinion, this number of deaths related to contracting measles remains significant worldwide. As pediatric nurse practitioners, lets make 2 statements loud and clear, Vaccinate your babies and children against measles and infection deaths from measles are vaccine preventable!

Click here for the each article from the March issue of Contemporary Pediatrics.

References:

1. Centers for Disease Control and Prevention. Measles history. November 5, 2020. Accessed March 19, 2024. Retrieved from https://www.cdc.gov/measles/about/history.html#:~:text=It%20is%20estimated%203%20to,of%20the%20brain)%20from%20measles

2. World Health Organization [WHO]. Measles. August, 9, 2023. Accessed March 20, 2024. https://www.who.int/news-room/fact-sheets/detail/measles

3. Sanderson, S., & Gaylord, N.M. Infectious Diseases. In, Maaks, D.L.G., Starr, N.B., Brady, M.A., Gaylord, N.M., Driessnack, M., & Duderstadt, KG. (2020), Burns pediatric primary care. 7th edition: Elsevier. Pages 479-481.

4. Centers for Disease Control and Prevention. Vaccine information statement, MMR vaccine (Measles, mumps, and rubella: What you need to know. 2021. Accessed March 20, 2024. https://www.cdc.gov/vaccines/hcp/vis/vis-statements/mmr.pdf

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This is serious: The results of a measles outbreak have harmful outcomes - Contemporary Pediatrics

Unlocking the Power of Influenza Vaccines for Pediatric Population: A Narrative Review – Cureus

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Unlocking the Power of Influenza Vaccines for Pediatric Population: A Narrative Review - Cureus

Human Papillomavirus Vaccines – Immunizations – American Academy of Pediatrics

Take an 11-minute break and view this Red Book Webinar that offers strategies and resources to increase the uptake of HPV vaccines and other recommended adolescent immunizations. Presenter Janet Siddiqui, MD, MBA, FAAP, ABIHM, also shares tips to help adolescents catch up with vaccines they may have missed due to the pandemic and reviews vaccine recommendations, coverage rates and barriers to vaccination.

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Human Papillomavirus Vaccines - Immunizations - American Academy of Pediatrics

The role of the pediatrician in school-based mental health services – Contemporary Pediatrics

Navigating school-based mental health services can be difficult for a child with mental health issues, their family, and at times, for the pediatrician.

James Wallace, MD, associate professor, Department of Psychiatry and Pediatrics, University of Rochester Medical Center, Child and Adolescent Psychiatry Faculty Trainer,The REACH Institute, explained how to traverse the crossover landscape between the pediatrician and school, in this Q+A interview with Contemporary Pediatrics.

Contemporary Pediatrics:

What is the pediatricians role when it comes school-based mental health services?

James Wallace, MD:

The single most important thing pediatricians can do is to consider the school as a natural and important ally and partner for managing pediatric behavioral health issues. Collaboration can help us make more accurate diagnoses, develop more effective multimodal treatment plans, and monitor progress in many areas. Without collaboration and communication, there are always missing pieces.

Contemporary Pediatrics:

How can schools and pediatricians work better together, or what are the missing links?

Wallace:

Medicine and education have different ways to think about children and teens. Each uses different language, follows different laws and regulations, and uses different strategies to intervene. Therefore, collaboration requires that both parties work hard to understand each other.

Simple routine communication procedures like sending the pediatrician a copy of every Individualized Education Plan (IEP) and 504 Accommodation Plan can help. Pediatric offices could develop a liaison for schools, [such as] clerical, medical assistant, nurse, and schools could develop a liaison for medical offices, [such as] clerical, teacher on special assignment, school nurse, counselor, or administrator.

To follow confidentiality laws (HIPPA, FERPA), having convenient releases of information (ROI) and making routine communication an expectation are huge steps in the right direction.1

Contemporary Pediatrics:

When is a good time to refer a patient to a mental health professional, perhaps going from a school therapist or counselor to something more?

Wallace:

When children and teens need evidence-based care that the school cannot provide, referring to community resources for that care is critical. Both schools and PCPs should keep a list of providers in the community with whom they have had good experiences and share that resource list.

Many states have Child Psychiatric Access Programs2 where primary care providers can call to get a list of appropriate referrals. But it is not an either/or. Students often continue with their school-based counseling as they enter community-based services. Collaboration between these 2 providers using the same language and skill-building can boost the impact of interventions and help generalize changes to more settings.

Contemporary Pediatrics:

What are schools and pediatricians lacking when it comes to providing resources to children with mental health concerns?

Wallace:

A school and pediatrician team can effectively assess and manage many, perhaps most, mental health concerns in children and teens, especially if the pediatric provider had intensive training in the assessment and management of mental health problems like the Patient-centered Mental Health in Pediatric Primary Care (PPP4) course offered through the REACH Institute.3

Primary care providers can also learn time-limited evidence-based Cognitive Behavior Therapy, Parent Training and Trauma interventions that they can provide themselves for milder cases or for when access to community therapy resources is delayed or unavailable.

Children with complex symptoms and impairment often need services and expertise beyond this core team. They often need a more specialized clinical therapist in the community. Some need consultation and treatment with a child and adolescent psychiatrist or psychiatric nurse practitioner.

Others need care management, in-home services, crisis services and acute care services beyond the resources of schools and primary care providers. These services are in addition to the school-pediatrician team, not instead of.

As the complexity and impairment expands, the village of collaborating providers needed to support the family and child should grow to meet the need. Call Access Programs can be a great resource for primary care providers to learn how to use the complex and often unique network of available local services.2

Contemporary Pediatrics:

Who are the students who are most vulnerable to mental health issues?

Wallace:

Children and teens who have suffered significant trauma are a very vulnerable group who are often in need of mental health service. Behavioral health problems have genetic and environmental components (nature and nurture), so they tend to run in families, especially when the whole family is struggling.

Those who have experienced adverse childhood events (ACES) are at risk, as are children who have been bullied, who are engaged in substance use, or who are in the LBGQT+ community. Non-English speakers, recent immigrants, people of color and other minority groups are at risk due to chronic stressors. They also face complex barriers to adequate health and mental health services, so they suffer doubly with greater needs and worse access.

Contemporary Pediatrics:

What signs should pediatricians and teachers/counselors look for in these patient populations?

Wallace:

Abrupt changes in mood, behavior, academic performance and/or relationships are worrisome signs. School refusal, self-injury or suicidal comments or behaviors, verbal or physical threats or aggression are red flags.

Subtle changes can signal a possible behavioral health problem early when the problems and impairment are milder and more amenable to change. School personnel and primary care providers have the advantage of knowing their students/patients over time so they can tell when a childs behavior changes. Familiar faces make it easier for students/patients and their families to disclose their concerns and seek help.

In medical settings, the United States Preventative Services Task Force (USPSTF) recommends universal screening for high frequency mental health problems like anxiety, depression, and suicidalityavailable on the ProjectTeachNY.org websitebecause some patients and families dont disclose their concerns unless asked.1,4

Some school districts have screening protocols for the same reason. We must all be on the lookout for significant changes in mood, anxiety, aggression, relationships, and academic performance so we can help these students/patients and all children and teens get the help they need.

References:

1. Families thrive with good mental health. Project Teach. Accessed February 9, 2024. https://projectteachny.org/

2. Integrating physical and behavioral health care for every child. National Network of Child Psychiatry Access Programs. Accessed February 9, 2024. https://www.nncpap.org/

3. REACH mental health training. The REACH Institute. Accessed February 28, 2024. https://thereachinstitute.org/training/#patient-centered-mental-health-in-pediatric-primary-care-ppp

4. Mental health conditions and substance abuse. US Preventive Services Task Force. Accessed February 9, 2024. https://www.uspreventiveservicestaskforce.org/uspstf/topic_search_results?category%5B%5D=20&searchterm=

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The role of the pediatrician in school-based mental health services - Contemporary Pediatrics

PCORI Awards CYSHCNet Researchers $5.5 Million to Study Transitions for Children and Caregivers from Hospital-to … – UNC Health and UNC School of…

Neal dejong, MD, MPH, at the UNC School of Medicine, David Y. Ming, MD, at Duke University School of Medicine and Ryan Coller, MD, at University of Wisconsin School of Medicine and Public Health, received $5.5 million to study hospital-to-home transitions across settings for children and youth with special healthcare needs.

Nearly one in five children, almost 14 million in the United States, have a special healthcare need that may require hospitalization. After a childs hospital stay, the transition back home can be risky, particularly for children with chronic health issues and complex medical conditions. To understand how to best support children and youth with special healthcare needs (CYSHCN), researchers of the CYSHCN National Research Network (CYSHCNet) received $5.5 million for a multi-site studyfunded by the Patient-Centered Outcomes Research Institute (PCORI)to compare two types of hospital-to-home transitional care to optimize outcomes.

The CYSHCNet researchers are led by David Y. Ming, MD, principal investigator, associate professor of pediatrics at Duke University School of Medicine; Neal dejong, MD, MPH, associate professor of pediatrics and member of the UNC Childrens Research Institute at the UNC School of Medicine; and Ryan Coller, MD, associate professor of pediatrics at the University of Wisconsin School of Medicine and Public Health.

Over a one-month post-discharge period, researchers will compare the effectiveness of two transitional care approaches focused doseversusextended dose reducing return visits to the hospital or emergency department and increasing parent-reported confidence. They will also evaluate the impact of each type of hospital-to-home transitional care on specific CYSHCN patient groups, including those with highly complex clinical needs and those from racial/ethnic minority groups or living in rural areas. Lastly, researchers will investigate how and why each approach to hospital-to-home transitional care is effective and for whom they work best.

The study team includes multiple community partners, including parents and caregivers with lived experience, clinicians, policymakers, and health system leaders. A community advisory board, primarily composed of a diverse group of parents/caregivers of CYSHCN, will work closely with the research team throughout the study. This collaborative effort aims to contribute to the equitable improvement of overall care for all CYSHCN transitioning from hospital to home.

About CYSHCNet:

CYSHCNet brings academic researchers and lived experience partners together to study the health care system issues that matter most to CYSHCN and their families. We help CYSHCN and their families by advancing knowledge and implementation of optimal health systems through innovative, rigorous multi-site studies, far reaching dissemination of findings, meaningful partnerships with families, and strong training of emerging CYSHCN investigators. Learn more:https://cyshcnet.org/.

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PCORI Awards CYSHCNet Researchers $5.5 Million to Study Transitions for Children and Caregivers from Hospital-to ... - UNC Health and UNC School of...

Reminder for IPRC Webinar Preventing Secondary Trauma and Practical Self Care for Pediatric Rehabilitation … – RCPA

Monday, March 4, 2024 12:00 pm 1:00 pm EST; 11:00 am 12:00 pm CST; 10:00 am 11:00 am MST; 9:00 am 10:00 am PST Register Here

Kara Monnin, PhD Kara Monnin, PhD, is a Clinical Assistant Professor of Pediatrics at Nationwide Childrens Hospital and Ohio State Universitys School of Medicine in Columbus, OH. Dr. Monnin provides clinical services across multiple inpatient units, including complex healthcare, inpatient physical medicine and rehabilitation, and acute care services (PICU, Trauma/Surgery/Neurosurgery), and operates on a consultative basis for Complex Care clinics. Dr. Monnin also serves as a member of the Advanced Illness Management/Palliative Care team at NCH and specializes in traumatic brain injury, rehabilitation populations, and children and adolescents with complex medical needs.

Kelsey E. Bakaletz, MSW, LISW Kelsey E. Bakaletz, MSW, LISW, is most importantly, a mother to 2-year-old Ellis. Kelsey is a clinical medical social worker in Developmental Behavioral Pediatrics at Nationwide Childrens Hospital in Columbus, OH. Kelsey received both undergraduate and graduate degrees from Ohio State University. Prior to working at NCH, Kelsey spent two years in rapid re-housing of homeless military veterans, and before that, she spent almost two years in therapeutic rehabilitation of adjudicated juvenile sex offenders. Kelsey is a member of the Trauma-Informed Care Work Group at Nationwide Childrens Hospital, working to provide and teach the best trauma-informed practices. Kelsey is passionate about treating every patient interaction as though the caregiver and child are part of our family, to lead with empathy, compassion, and determination that we resist re-traumatization.

Objectives: At the end of this session, the learner will:

Audience: This webinar is intended for all members of the rehabilitation team, including medical staff, nurses, physical therapists, occupational therapists, speech language pathologists, licensed psychologists, mental health professionals, and other interested professionals.

Level: Intermediate

Certificate of Attendance: Certificates of attendance are available for all attendees. No CEs are provided for this course.

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Reminder for IPRC Webinar Preventing Secondary Trauma and Practical Self Care for Pediatric Rehabilitation ... - RCPA