Once again, a vital, one-of-a-kind lifesaving course on aerospace physiology for helicopter operators will be offered at this years Heli-Expo in Anaheim, California. This years class has been moved back to Jan. 27, 2020.

The full-day course, taught by one of the industrys leading subject matter experts, Dr. Dudley Crosson, will focus on the latest research and developments on some old, some not-so-old, and in many cases very misunderstood topics that over the years have led to numerous helicopter accidents and pilots deaths. The course looks at current topics from an operational perspective.

Subjects include the deadly side effects of fatigue and sleep deprivation, the dangerous and negative impact of dietary supplements on flight crews, how stress can destroy a pilots decision making process, and finally the inner-workings and physiology behind spatial disorientation.

To register for this course or any of the other courses offered at Heli-Expo 2020, go tohttps://www.rotor.org/home/heli-expo/attend and click on the Education Tab, then Professional Education.

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Aerospace physiology and human performance update course to be provided at Heli-Expo 2020 - Vertical Magazine

Often, cars in India are designed keeping in mind the physiology of males, and thus put women at risk when it comes to comfort and safety.

The way cars are designed in India could be putting women who drive them at risk, experts at a panel discussion at the recently-held Bengaluru Tech summit said.

Seatbelts and airbags proved to be more deadly to women passengers than male, said Cynthia Srinivas, Senior Engineering Manager at Intuit. The reason? Cars are primarily designed by men and are constructed to suit male physiology.

Though data released by the government points to the fact that most fatalities in road accidents in India are men, this could be attributed to risk-taking behaviour and the fact that most cars are driven by men.

However, Criado Perez, a British journalist, explains in her book Invisible women: Exposing data bias in a world designed for men that a woman who is in a collision is 47% more likely to be seriously injured than a man and 17% more likely to die. This is attributed to the flawed design: engineers and designers take note of the male physiology as the default, which negatively affects the experience of female users.

She explains, for example, that the seatbelt in cars is designed with the average man in mind. They are made for people with the height of an average male, and the width of male shoulders. She says pregnant women, or the bust of women is not taken into account, which is the reason why many women prefer not to wear seatbelts.

Even when women do wear seatbelts, she explains, they aremore adversely affected during a crash due to the phenomenon called whiplash. During a crash, you go forward and come back with an enormous amount of force, which has the capacity to break your neck. Men are not as adversely affected as women by this phenomenon because their neck muscles are more defined. The current seat-belt design does not take this into account, experts say.

Airbags, too, have been designed based on crash data taken from a male default dummy during testing. Thus, smaller people, including children and women, are not adequately protected by airbags in cars. This is because where their bodies hit during a crash is completely different from that of a "default male".

The cars are also not easy to use for shorter or smaller drivers since they sit closer to the edge of the seat and it becomes difficult for them to reach the car pedals and often have to strain to see over the wheel. This brings their heads and chests closer to the steering wheel and the airbag, making their bodies more susceptible to injuries, researchers say.

However, this bad design is not just limited to the realm of private cars. Buses too are designed taking into account the average stride of a man, which makes it harder for women to enter a bus. This is because they are generally shorter, and take smaller strides.

What is the solution?

The panel at Bengaluru Tech Summit spoke of the importance of female representation at all levels, whether it be leadership or design. One of the speakers, Cynthia Srinivas, an engineering manager, especially highlighted the point of representation in design, saying that the risk of being a woman extends even when youre within the comfort of your own car. Women in leadership can also be more empathetic, which makes all the employees fare better in their work, not just women, she said.

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The way cars are designed in India puts lives of women at risk: Experts - The News Minute

DEERFIELD, Ill., Nov. 17, 2019 /PRNewswire/ -- Mezzion Pharma Co. Ltd. (140410: KOSDAQ) today announces the presentation of data from its pivotal clinical trial for its new orphan drug for the treatment of adolescents with single ventricle heart disease.

Dr. David Goldberg, Pediatric Cardiologist, Children's Hospital of Philadelphia presented the top line results from the FUEL (Fontan Udenafil Exercise Longitudinal Trial) at the Annual Scientific Session of the American Heart Association (AHA) and in a Mezzion Sponsored scientific symposium titled "Fontan Physiology and Results of the FUEL Trial". The primary aim of the FUEL trial was to improve the exercise capacity in adolescents with congenital single ventricle heart disease who have undergone a series of surgeries to palliate the effect of a missing ventricle in their heart. The results of the 400 subject, double-blind, placebo-controlled study showed that the primary aim of improving exercise capacity in adolescents with congenital single ventricle heart disease (SVHD) was achieved.

The top line data from the FUEL trial, which was designed to evaluate the safety and efficacy of udenafil for the treatment of SVHD adolescents, showed that subjects taking udenafil over a 6-month period had a significant improvement in exercise capacity as measured by oxygen consumption at the ventilatory anerobic threshold (VO2 at VAT). Work rate at VAT and ventilatory equivalents of carbon dioxide at the VAT (VE/VCO2) were likewise improved. While peak VO2 also improved, the data did not reach statistical significance. VO2 at VAT measures the level of oxygen consumption at which one changes from aerobic to anaerobic activity, a clinically relevant level of exertion that is typical of what is encountered in routine exercise activity. Work rate measures the power (watts) generated at the VAT while VE/VCO2 is an index comparing the volume of CO2 with the total respiratory volume. All of these measures demonstrated statistically significant improvement in the udenafil treated group compared to the placebo treated group, as described later in this Press Release.

The FUEL trial was conducted in partnership with the Pediatric Heart Network (PHN) at a total of 30 Pediatric Heart Network [http://www.pediatricheartnetwork.org] and auxiliary sites throughout the U.S., Canada, and Korea. The PHN is funded by the National Heart, Lung, and Blood Institute, part of the National Institutes of Health.

The Fontan Surgery

The Fontan operation is a palliative procedure for children born with functional single ventricle congenital heart disease. Following the Fontan operation there is no ventricular pump to propel blood into the pulmonary arteries. Instead the blood returns to the lungs via passive flow from the systemic veins. This results in a circulation characterized by elevated central venous pressure and a chronically low cardiac output. Over time, these inherent characteristics of Fontan physiology result in a predictable, persistent deterioration of cardiovascular efficiency, as marked by a progressive decline in exercise performance, a decline that accelerates after puberty. This decline in cardiovascular efficiency is associated with the development of substantial morbidities and a significantly shortened life expectancy.

The Fontan Physiology and Exercise Capacity: VO2at VAT is the appropriate measure in Fontan subjects

Exercise capacity of study participants was measured in an exercise lab using a special stationary exercise bicycle that is programmed to increase resistance so that their maximum effort can be assessed. The subject peddles the bicycle while wearing a special mask that allows for the measurement of oxygen consumption. The bicycle automatically increases in resistance requiring the subjects to increase their effort and consume increasingly more oxygen up to their maximum effort.

In the symposium, Dr. Stephen Paridon, Pediatric Cardiologist and Exercise Physiologist, Children's Hospital of Philadelphia explained that exercise capacity can be measured by evaluating the maximal oxygen consumption at the subject's maximal effort (peak VO2) or by measuring the oxygen consumption at the ventilatory anerobic threshold (VO2 at VAT). Peak VO2 is the classical measurement of oxygen capacity in those with two functional ventricles, and therefore was used as the primary outcome measurement in the FUEL trial. Dr. Paridon explained that the new finding from the FUEL trial and other relatively recent research suggest that peak VO2 is not the most appropriate measurement to assess exercise capacity due the unique physiology resulting from the Fontan palliation. Fontan subjects do not have a ventricle to pump the venous blood to the lung. Blood flow to the lung depends solely on the central venous pressure in the body. The central venous pressure in those who have undergone the Fontan operation is elevated at baseline, and typically rises to the degree needed to meet metabolic demands at high levels of exertion, thereby creating a limit to the amount of exercise that can be achieved. While peak VO2 demonstrated improvement of about 3.2% in the udenafil treated group vs 0% in the placebo group, statistical significance (p value=0.07) was not achieved.

Dr. Paridon further explained that VO2 at VAT, may be a more relevant measure of exercise capacity in the Fontan physiology because it occurs at a lower central venous pressure and appears to be less limited by this unique physiology. VO2 at VAT improved by 2.9% in the udenafil group versus a 1.0 % decline in the placebo group and was statistically significant (p value=0.009). Significant improvement also was achieved in two other key parameters which independently demonstrate the Fontan subjects' improved exercise capacity at the ventilatory anerobic threshold: work rate at VAT and ventilatory efficiency (VE/VCO2) at VAT. Dr. Paridon explained that any improvement in VO2 at VAT is clinically relevant to the SVHD patient population.

Regulatory Status

A meeting with the Cardiovascular and Renal Division (DCaRP) of the US FDA was held on October, 8, 2019 for the purpose of presenting the topline data from the FUEL trial and to reach a concurrence with the FDA on the path forward toward submitting a new drug application (NDA) for the approval of udenafil for improving the exercise capacity in subjects with SVHD.

The FDA provided very helpful and constructive guidance. Based on its initial review of the top line data from the FUEL trial, the FDA confirmed that Mezzion can proceed with the submission of the NDA for udenafil for improving the exercise capacity of SVHD subjects and that the submission would be "fileable" provided that the submission contained all of the required information.

Accordingly, in view of the positive results from the FUEL Trial and the safety data collected about udenafil, and in view of the constructive guidance by the FDA, Mezzion intends to expeditiously submit a New Drug Application to the FDA to seek approval for the use of udenafil to treat patients with SVHD who have undergone Fontan palliation.

Mezzion's Clinical Program

In addition to the pivotal FUEL trial, Mezzion continues forward in its clinical program in partnership with the PHN with a long-term study to evaluate the safety of udenafil (FUEL-OLE Study) ClinicalTrials.gov Identifier: NCT03013751) and a study to evaluate the effect of treatment on Fontan-associated Liver Disease (FALD study). Because of the elevated central venous pressure, liver fibrosis, which can lead to liver cirrhosis, is prevalent in almost all Fontan subjects starting at a very early age. (ClinicalTrials.gov Identifier: NCT03430583).

Orphan Drug and Rare Pediatric Disease Status

On 31 August 2015, The Office of Orphan Products Development (OOPD) granted orphan drug status for udenafil in the treatment of single ventricle congenital heart disease with Fontan physiology [FDA Letter, OOPD, Designation Request #14-4497]. On 20 April 2017, OOPD designated udenafil for treatment of single ventricle congenital heart disease as a drug for "rare pediatric disease".

New Patents

Mezzion has submitted patent filings based on the new findings from the FUEL trial. The new patents, if the claims are allowed, should further strengthen the patent position for Mezzion in the United States and elsewhere. Mezzion is not only protected by different patent families, but its exclusivity is further enhanced by other forms of protection such as regulatory and proprietary know-how. We believe that this matrix of intellectual property provides Mezzion with a unique position to provide a much-needed new pharmacotherapy to Fontan patients.

Udenafil

Udenafil is a unique phosphodiesterase (PDE)-5 inhibitor being developed in the United States (US) to improve and maintain exercise capacity in adolescents with Fontan physiology. PDE5 inhibitors are a class of medications that have demonstrated utility in reducing pulmonary vascular resistance and improving ventricular performance in patients with pulmonary hypertension (Galie et al 2005; Humpl et al 2005; Behling et al 2008; Nagayama et al 2009; Guazzi et al 2011). Udenafil is a unique PDE5 inhibitor that that has undergone Phase III testing in adolescents with Fontan physiology and has demonstrated excellent safety and tolerability in this population, in which cardiac output and exercise are limited by the absence of a sub-pulmonary ventricle.

Mezzion Pharma Co. Ltd.

Mezzion Pharma is headquartered in South Korea. Mezzion Pharma and its wholly owned subsidiary, Mezzion Pharmaceuticals, Inc., have administrative offices in Deerfield, Illinois and Boca Raton, Florida. Mezzion Pharma is an innovation-driven pharmaceutical company that is focused on discovering, developing, and commercializing novel therapeutics in the field of rare pediatric diseases. Mezzion Pharma is a publicly-listed pharmaceutical company in Korea on the Korean stock exchange under (140410:KOSDAQ).

Forward-Looking Statements

Statements contained in this press release regarding matters that are not historical facts are "forward-looking statements" within the meaning of the Private Securities Litigation Reform Act of 1995. Because such statements are subject to risks and uncertainties, actual results may differ materially from those expressed or implied by such forward-looking statements. Such statements include, but are not limited to, statements regarding: Mezzion Pharma's expectations regarding the potential benefits of udenafil; Mezzion Pharma's expectations regarding the anticipated timing of any future clinical trials; Mezzion Pharma's expectations on regulatory submissions for marketing approval of udenafil for the treatment of Fontan patients to improve exercise capacity in the United States, including the timing of these submissions; and Mezzion Pharma's expectations regarding the potential commercial launch of udenafil, including the timing of a potential approval of udenafil. Risks and uncertainties that contribute to the uncertain nature of the forward-looking statements include: the expectation that Mezzion Pharma will need additional funds to finance its operations; Mezzion Pharma's or any of its collaborative partners' ability to initiate and/or complete clinical trials; the unpredictability of the regulatory process; the possibility that Mezzion Pharma's or any of its clinical trials will not be successful; Mezzion Pharma's dependence on the success of udenafil; Mezzion Pharma's reliance on third parties for the manufacture of Mezzion Pharma's udenafil and udenafil tablets; possible regulatory developments in the United States and foreign countries; and Mezzion Pharma's ability to attract and retain senior management personnel.

These and other risks and uncertainties are described more fully in Mezzion Pharma's most recent filings with the Statements under the Private Securities Litigation Reform Act: with the exception of the historical information contained in this release, the matters described herein contain forward-looking statements that involve risk and uncertainties that may individually or mutually impact the matters herein described, including but not limited to FDA review and approval, product development and acceptance, manufacturing, competition, and/or other factors, which are outside the control of Mezzion Pharma. All forward-looking statements contained in this press release speak only as of the date on which they were made. Mezzion undertakes no obligation to update such statements to reflect events that occur or circumstances that exist after the date on which they were made.

Contact:

Dr. James YeagerTel: +1-847-2122679Email: james.yeager@mezzion.comDeerfield, Illinois, USA

Mr. YT SongTel: +82 2 560 8011Email:ytsong@mezzion.co.krSeoul, Korea

SOURCE Mezzion Pharma Co. Ltd.

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Mezzion Pharma announces the presentation of the FUEL Trial data at the American Heart Association Meeting in Philadelphia - PRNewswire

Top Hat Intro Courses seamlessly combine interactive textbooks, lecture slides, quizzes and assignments on one platform, supporting student learning before, during and after class

Top Hat is dedicated to empowering professors to deliver engaging and effective learning experiences, while improving affordability and the return students get on their educational investment

TORONTO Top Hat, the leading active learning platform for higher education, today announced the release of six Top Hat Intro Coursesall-in-one digital course solutions that provide all the content and assessment tools professors need to deliver their perfect course, while remaining fully customizable to fit any classroom.

Top Hat Intro Courses: Full course solutions, all on one platform

Top Hat Intro Courses are the only full course solutions that enable professors to quickly and easily provide engaging and effective learning experiences while improving student outcomes. Interactive readings, assignments, lecture slides, instructor resources, and integrated assessment tools to gauge student comprehension before, during, and after class are all accessible from a single platform.

Every Top Hat Intro Course is designed so that professors can easily incorporate their own course materials, from text to slides to videos to quizzes. Additionally, Top Hats integrated gradebook and weekly reports on student progress equip professors with actionable insights to pinpoint difficult topics and identify struggling students so professors can intervene early.

The most effective courses are the ones that enable professors to teach their students using a variety of approaches, tools, and content, said Nick Stein, CMO, Top Hat. With Top Hat Intro Courses, we are taking that approach one step further, to empower professors with flexible, affordable, and customizable content that motivates learners and ultimately supports student success.

Todays launch features the release of six Top Hat Intro Courses for four popular subjects:

Top Hat Intro Course for Psychology

Top Hat Intro Course for Economics, with separate textbooks: Principles of Economics, Principles of Macroeconomics, and Principles of Microeconomics

Top Hat Intro Course for Anatomy & Physiology

Top Hat Intro Course for Public Speaking

Chosen for their ability to have a big impact on student success, these subjects are taught in more than 42,000 courses, to more than 2.9 million students at colleges and universities across the United States. Top Hat Intro Courses incorporate interactive textbooks that have been used, modified, expanded, and improved by professors in the classroom for years. Based on feedback from our community of users, the authors have further strengthened and updated these texts to ensure a high-quality standard that also maintains affordability for students.

Changing the textbook paradigm

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Designed for active learning: Student comprehension is supported through features like rollover definitions, interactive 3D models, comprehensive chapter summaries, and expansive study guides.

Affordable: Top Hat Intro Course for Psychology is only $80 for the textbook and the full Top Hat platform, whereas publisher print textbooks bundled with their assessment platforms are $200 or more.

Great for student engagement: Professors encourage student participation through interactive presentations packed with polls and assessments, facilitating engaging discussions via student devices.

Holistic and seamless: All content is kept up to date and in one place, so professors never have to piece together textbook readings, e-learning modules, and other in-class materials.

Customizable: Easy-to-use editing tools let professors adjust content to fit their curriculum.

Rich with actionable insights: Data points and progress reports show professors where students are struggling, enabling them to easily reach out and intervene early.

Top Hat Intro Courses drive up the educational value for students by improving the quality and flexibility of content and instruction, with the ultimate goal of raising student success rates. Top Hat is focused on driving down the cost of higher education by offering affordable high-quality content. Through working with professors, Top Hat is supporting a new standard for how forward-thinking and engaged educators are setting up their students for success.

What Top Hat professors say

Students like the continuity of what we cover in lecture and whats in the textbook. They like that theres no wasted space, theyre not forced to read something that doesnt matter, because its not germane to what were discussing. Theres a tremendous energy barrier for students to participate. So were using all these techniques to reduce that energy barrier and encourage engagement, because when they participate, they learn, and they will gladly come afterwards into my office and ask more questions.

Joe Crivello, Professor of Physiology and Neurobiology, University of Connecticut, and the lead author of the Top Hat textbook Anatomy & Physiology in Context

What I like most about the text is that it provides a lot of examples and gives feedback to students. It really helped students to understand the material more clearly. They know how to apply a theoretical concept to the real world. The instant feedback feature of the assignment does allow them to evaluate their understanding of the material instantly.

Megharanji Hazra, Lecturer of Economics and Top Hat Intro Course for Economics user, Towson University

Top Hat has enabled me to deliver my course differently and allowed my students to review materials more effectively before exams. This is linked to higher exam scores and fewer failures compared to my previous five years of teaching this course.

Jamie Kleinman, Assistant Professor in Residence of Psychology and Top Hat Intro Course for Psychology user, University of Connecticut

Any instructor will tell you that finding the right textbook is hard. You use maybe 60 percent of whats in it and then you have to supplement with other materials. A teacher should adopt technology not because it makes their life easier, but because it makes student learning better. What sold me on Top Hat initially was the ability to provide quantitative and qualitative feedback through the app.

Luke Green, Instructor of Communications Studies, St. Cloud Technical & Community College, and contributing author of the Top Hat textbook Effective Public Speaking

About Top Hat Top Hats interactive, cloud-based teaching platform enables professors to engage students inside and outside the classroom with compelling content, tools, and activities. Millions of students at 750 leading North American colleges and universities use the Top Hat teaching platform. To learn more, visit https://tophat.com.

View source version on businesswire.com: https://www.businesswire.com/news/home/20191121005135/en/

Contacts

Dianna Lai Read dianna.lairead@tophat.com

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Introducing Top Hat Intro Courses: Everything Professors Need to Help University Students Learn--All on One Platform - Financial Post

As part of our initiative called Curious Cornhuskers, an anonymous reader asked The Daily Nebraskan, What's the little building next to Abel-Sandoz used for and what did it used to be? The one on Vine St. across from the soccer fields.

This small building is the American Mathematics Competitions Building. According to emeritus professor of mathematics and former American Mathematics Competitions employee Steven Dunbar, the building has served as the headquarters of a construction company, been the location to sort out thousands of mathematics tests and was used by University of Nebraska-Lincoln Campus Recreation. It currently houses a physiology laboratory used by the UNLs Nutrition and Health Sciences department.

The physiology lab used to be located in the basement of Mabel Lee Hall, but in May 2019, it was temporarily relocated to the American Mathematics Competitions Building due to Mabel Lee Halls scheduled demolition, according to nutrition and health sciences professor Terry Housh. Housh said the lab will relocate back to the basement of the new Mabel Lee Hall once it is rebuilt.

In years prior, the building was the headquarters of a construction company. Dunbar said whenever the construction company had leftover material from a project, they would add on to the building.

You can sort of see that there were different materials in various places in the building, and it had a couple of different levels in it so it sort of felt like it had been added on, Dunbar said.

Later, UNL Campus Recreation operated out of the building. According to Dunbar, the building was used to rent out much of the same equipment Campus Recreation rents out today, including canoes, kayaks, badminton sets and golf clubs. He said the garage located on the east side of the building was used for loading the rental boats.

After Campus Recreation moved into its current space west of 14th Street between Vine and W streets, the American Mathematics Competitions moved its world headquarters into the building. The organization had previously been run from the home of Walter Mientka, a former UNL mathematics professor, before outgrowing that space, according to Rachelle Jensen, administrative technician for the UNL math department and former employee for the American Mathematics Competitions.

The American Mathematics Competitions administered several different exams for middle and high school students with the purpose of finding six students to represent the United States at the International Mathematical Olympiad, according to Jensen.

We have a lot of stuff that came through that office, Jensen said. Wed get all these exams and stacks and we had a small storeroom in the back where wed store answer sheets, the exam booklets, teachers manuals anything that we put together with the contest to go out to the schools.

Dunbar said that he estimates between 300,000 and 500,000 exams came through the building each year to be packaged and scored.

It was an interesting operation that not a lot of people knew about, but we were there, Jensen said.

In 2015, the American Mathematics Competition moved to Washington D.C., leaving the building vacant until May 2019, according to Jensen.

It was kind of an odd little building but it actually suited our purposes really well and was really well-suited to what we were doing, Dunbar said. It actually worked out quite well for us. It was a good location.

news@dailynebraskan.com

Continued here:
Curious Cornhuskers: What's the little building next to Abel-Sandoz used for? - Daily Nebraskan

The woman scientist whose work formed a basis for the Nobel Prize for the structure of DNA has not ... [+] been appreciated until recently. And Rosalind Franklin's legend may not do justice to the compassionate, passionate scientist who brought the world its first true visions of the makeup of all life.

Recent years have seen landmark advances for women in science. The year 2009 saw three women receive Nobel prizes in the sciences: Elizabeth Blackburn, Carol W. Griede, and Ada E. Yonath. In 2018, Donna Strickland became the third female in history to win the Nobel Prize in Physics, and synthetic biologys own Frances Arnold became the fifth female ever to be awarded the Nobel Prize in Chemistry. Recent research from the National Science Foundation indicates that more women than men are receiving undergraduate degrees in science and engineering these days.

Still, enormous disparities persist. According to the UNESCO Institute for Statistics, less than 30% of the worlds researchers are women. Particularly regarding the Nobel, only 3% of the science Nobel Prizes in Physiology and Medicine, Chemistry, and Physics have been awarded to women.

One of the most complicated cases of equity and the Nobel Prize is that of Rosalind Franklin. An English chemist, Franklin developed the methods that led to the capture of Photo 51 the famed x-ray crystallography photo that directly led James Watson and Francis Crick to the discovery of the double-helix structure of DNA. But how Watson and Crick came to receive Franklins photography is problematic they obtained it without her knowledge from Maurice Wilkins, a researcher at the same lab. Wilkins and Franklin had a challenging relationship: as head of the lab, Wilkins never communicated to Franklin that she was not working under him and that the two were independent researchers.

Although Franklins work was essential to Watson and Cricks discovery, she was not appropriately credited in initial publications about the structure. Only in Watsons book, published years later in 1968, was the first mention of her contribution. Watson, Crick, and Wilkins won the Nobel Prize in Physiology and Medicine in 1962 for their work; Franklin died at the much-too-young age of thirty-seven due to ovarian cancer in 1958, just four years before the Nobel was awarded. The Royal Swedish Academy of Sciences does not confer the Nobel posthumously, but the Nobel Museum in Stockholm does note that she was not awarded her due credit.

Photo 51 is the nickname given to this X-ray diffraction image of crystallized DNA taken by Raymond ... [+] Gosling, a graduate student working under the supervision of Rosalind Franklin in May 1952 at King's College London, while working in Sir John Randall's group. The image was tagged "photo 51" because it was the 51st diffraction photograph that Franklin and Gosling had taken. It was critical evidence in identifying the structure of DNA.

Part of this doubt of whether or not Franklin would have been rightly awarded the Nobel is rooted in the circumstances under which she worked. According to her niece, also named Rosalind Franklin, Franklin was a gifted, methodical chemist with an incredible independent work ethic and sharp focus on work in a way that did not fit the mold of what a woman in a mans world was supposed to look like at that time. Her passion and intensity for her work, coupled with little patience for small talk and Wilkins great nervousness when around her, created a high-tension relationship between the two.

Watsons view of women also detracted from the power of her scientific work. Her niece recounts a time when Watson attended a talk that Franklin gave. Watson admitted that he really wasn't listening because all he could think was that she would be rather attractive if she changed her hair or dressed differently. According to a 2015 article from the Guardian, Ironically, the data provided by Franklin to the MRC were virtually identical to those she presented at a small seminar in Kings in autumn 1951, when Jim Watson was in the audience. Had Watson bothered to take notes during her talk, instead of idly musing about her dress sense and her looks, he would have provided Crick with the vital numerical evidence 15 months before the breakthrough finally came. For her niece, his outright concession that he wasnt listening at all pretty much says it that women and their work were not respected by Watson, despite Franklins obvious prowess and dedication to chemistry.

Franklin was an avid hiker and traveler, and usually spent her vacations walking or cycling with ... [+] family or friends such as Vittorio and Denise Luzzati. Here she is in 1949 on a hiking trip in the Alps.

Although Rosalind Franklins scientific contributions are better known today, there is much less of an accurate portrayal of who she was as a person as she is often presented just from an intellectual, intense perspective. The younger Rosalind has a plethora of incredible stories about her aunt as a woman who loved theater and mountain climbing and would walk 25 miles a day. Even more specifically as a scientist, Franklins character and dedication shone through in the smallest stories that have been vastly underrecognized.

Her legacy has been amazing [speaking to her] ethics...the way she did her work, the way she led her life with integrity, says her niece. She just loved that she was contributing, she was making a difference. That was important. She would never have thought of [science as] a race and it would have been anathema to do that. So she liked the process, she just loved that discovery and that opportunity to look at things as a contribution to mankind.

That love for the process with evident in her incredibly methodical approach of analyzing her x-rays of DNA. Watson and Crick jumped to analyze the B form to confirm the double helix structure as quickly as possible; however, Franklin, despite her intuition that the B form was correct, first eliminated the A form a methodology deeply rooted in a scientific and personal commitment to doing the right thing the right way. Her niece recounts an instance when Franklin had grant money remaining from a project and attempted to return it, only to be regarded with complete befuddlement because no one had ever done that before (and still generally do not today either). She was a bit of a martyr for the cause of equal representation and fairness and equity in science, says her niece. People like to put people in boxes, but they have so much more in their lives than ever seen. Franklin is a living testament to that fact a dynamic personality often overshadowed by the stereotypes of her time.

The irony of Franklins position in history does not escape her niece. [Her story today] would not be so prominent if Watson in particular had given her the credit that she deserved, she says. Its so important to stand on the shoulders of those who came before you. And Franklin did just that: surrounded by the strong women in her family who came before, she didnt feel limited in exploring her passions and advancing her learning.

Rosalind Franklin looking through a microscope in 1955, created at The MRC Laboratory of Molecular ... [+] Biology.

Although she did not have a family of her own, family was the cornerstone of Franklins life and made her who she was. Her niece believes that her aunts story serves as an invaluable lesson for parents today to empower children to discover what they want to do and be respectful of their journey as well, particularly for girls. It gives her hope that Franklins narrative is being reclaimed and presented in a more complete picture, rather than a one-dimensional story.

Its our time, Franklins niece says, a time for women to speak up and speak out. Rosalind would be thrilled to serve as an inspiration, especially for young girls today, but wouldn't want to see herself as the iconic feminist representative, just who women should be.

SynBioBeta 2019 was treated to a very special lunch discussion featuring Nobel Laureate Frances ... [+] Arnold, investor Una Ryan, and musician and consultant Rosalind Franklin, niece and namesake of the research pioneer. The three women engaged the audience in a thoughtful discussion about why there arent more women leaders in synthetic biology and how to change that. The unanimous advice: be kind to one another.

SynBioBeta 2019 featured a very special discussion featuring Nobel Laureate Frances Arnold, investor Una Ryan, and musician and consultant Rosalind Franklin, niece and namesake of the research pioneer. The three women engaged the audience in a thoughtful discussion about why there arent more women leaders in synthetic biology and how to change that. The unanimous advice: be kind to one another.

Acknowledgement: Thank you to Aishani Aatresh for additional research and reporting in this post. I am the founder ofSynBioBeta, and some of the companies that I write about are sponsors of theSynBioBeta conference(click herefor a full list of sponsors).

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The Scientist Who First Showed Us The Double Helix: A Personal Look At Rosalind Franklin - Forbes

GRAFTONOn November 20, the Rotary Club of Grafton held their Student of the Month Luncheon at Grafton High School.

During the event, the ProStart Class, taught by Bonnie Woods, prepared and served a traditional Thanksgiving dinner themed lunch.

Two students from Grafton High Schools senior class were honored at the November Students of the Month. Representing their class and school were Brooke Moyer and Aaron Pander.

Brooke Moyer is the daughter of Tammy and Homer Moyer. At Grafton High School, she is a member of the Bearcat Marching and Concert bands, as a piccolo and flute player.

Brooke has already been accepted into the West Virginia University School of Medicine, where she will pursue a degree in Exercise Physiology. After graduation from the program, she hopes to become a Physical Therapist.

When not busy with her studies or performing with the bands, Brooke keeps herself busy working part-time at Old Navy.

Aaron Pander is the son of Kristy and Jason Pander. As a student at Grafton High School, he is a member of the National Honor Society. He has also participated on the cross country and track teams.

Outside of his studies, Aaron stays busy as a member of the Eagle Scouts. As a community service project, he built a bridge at Tygart Lake State Park.

Following graduation from GHS, Aaron will be traveling as a missionary for two years, with the Church of the Later Day Saints. Upon his return, he plans on attending West Virginia University to obtain a degree in computer science and electrical engineering. His goal is to one day develop software.

Following the presentation of each student, Rotary President Greg Cartwright and Rotarian Lorraine Isner presented Brook and Aaron with Student of the Month certificates, a book entitled 365 Daily Motivations and logic puzzles to help keep their minds sharp.

Congratulations to both students on their achievements!

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Rotary Club of Grafton recognizes students of the month - Mountain Statesman

Doctors have put humans into a state of suspended animation for the first time in a groundbreaking trial that aims to buy more time for surgeons to save seriously injured patients.

The process involves rapidly cooling the brain to less than 10C by replacing the patients blood with ice-cold saline solution. Typically the solution is pumped directly into the aorta, the main artery that carries blood away from the heart to the rest of the body.

Known formally as emergency preservation and resuscitation, or EPR, the procedure is being trialled on people who sustain such catastrophic injuries that they are in danger of bleeding to death and who suffer a heart attack shortly before they can be treated. The patients, who are often victims of stabbings or shootings, would normally have less than a 5% chance of survival.

Samuel Tisherman, at the University of Maryland, in Baltimore, described the trial at a recent symposium held by the New York Academy of Sciences. He said at least one patient had had the procedure but did not elaborate on whether that patient or any others had survived. The first time the team performed the process was a little surreal, he told New Scientist magazine.

Rapid cooling of trauma victims is designed to reduce brain activity to a near standstill and to slow the patients physiology enough to give surgeons precious extra minutes, perhaps more than an hour, to operate. Once the patients injuries have been attended to, they are warmed up and resuscitated.

One aim of the US trial is to reduce the brain damage that patients are often left with if they survive such serious injuries. When the heart stops and blood stops circulating, the brain quickly becomes starved of oxygen, suffering irreparable damage within about five minutes.

The trial will compare the outcomes of 20 men and women who receive standard emergency care or EPR. The trial is due to run until the end of the year, and full results are not expected until late 2020.

Previous studies have shown that EPR can help save injured pigs, though it is by no means successful all the time. We felt it was time to take it to our patients, Tisherman told New Scientist, which was the first to report on the work. Now we are doing it and we are learning a lot as we move forward with the trial. Once we can prove it works here, we can expand the utility of this technique to help patients survive that otherwise would not.

One complication of the procedure is that patients cells can become damaged as they are warmed up after surgery.

Though Tishermans talk was entitled Suspended Animation, he said he was not exploring ways to preserve astronauts on deep space missions. I want to make clear that were not trying to send people off to Saturn, he told New Scientist. Were trying to buy ourselves more time to save lives.

Nasa considers that full-on hibernation for interstellar travel is still a distant prospect. The US space agency is instead investigating ways of putting astronauts into a torpor, so reducing their metabolism for extended periods.

Kevin Fong, a consultant anaesthetist at University College London hospital, and the author of Extremes: Life, Death and the Limits of the Human Body, said: Emergency preservation and resuscitation is an attempt to protect a dying patient by dramatically dropping their body temperature and forcing their physiology into slow motion. It can take a situation in which there are mere seconds to save someones life and smear that out into many minutes.

The cardiothoracic surgeons have been doing something very similar for decades but this is about moving that technique forward, into the emergency department or perhaps maybe even out into the field. In emergency medicine were always trying to blur the line between life and certain death, to create something that looks like hope where none previously existed. If EPR works, itll be a game-changer.

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Humans put into suspended animation for first time - The Guardian

The question was raised, Are leaders born? Or, are they raised? One conversation with Angela Cudger, and you will know that this is what she was born to do. Lead. Angela is no stranger to hard work. It seeps through everything she says and does. Angela Cudger is a Master Holistic Health Coach and Integrative Lifestyle Expert. She is the Primary Educator and Founder of Legacy Holistic Health Institute.

Earning her Bachelors of Cardiopulmonary Care Sciences from Georgia State University and her Masters of Medical Science in Anesthesiology from Emory University School of Medicine, she is educated to the medical school level in Human Anatomy, Physiology, and Chronic Disease Management. She is a graduate of the Institute for Integrative Nutrition (IIN) and currently certifies Holistic Health Coaches.

Angela is the Founder and Primary Teacher of Legacy Holistic Health Institute, where she develops health and wellness leaders into Holistic Health Coaches. Her program is the only one of its kind on the market that blends anatomy and physiology, disease management, holistic nutrition, and practical coaching skills with spirituality, professional and business development. Health Coaches who graduate from Legacy are cutting-edge and relevant.

At the Legacy Holistic Health Institute, future Health Coaches are empowered with the following:

Over 100 different health and wellness theories that blend physiology, disease prevention, and behavioral changes

The Science of Body System, Understanding Chronic Disease and Management and Holistic Nutrition and Dietary Theories

Real-time, Step-by-step Business Growth, and Development Strategies

Successful Self Care, Personal Growth and Professional Development

And so much more!

Merit-based scholarships are available for those who qualify.

Media ContactCompany Name: Legacy Holistic Health Institute Contact Person: Angela CudgerEmail: Send EmailPhone: 1-844-385-1799City: AtlantaState: GeorgiaCountry: United StatesWebsite: http://www.discoverlegacy.info

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The Unstoppable Angela Cudger is Taking The Health Industry By Storm - Press Release - Digital Journal

Brian D. Nielsen, Ph.D., PAS, Dipl. ACAN

Brian Nielsen, PhD, MS, PAS, Dipl. ACAN, is an animal science professor at Michigan State University, where he teaches senior level courses in equine exercise physiology and advanced horse management. His research interests include equine exercise physiology, young horse development, and nutrition.

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Young Horses: Long-Term Effects of Nutrition and Exercise - TheHorse.com