Category Archives: Physiology

Baton Rouge, New Orleans, Lafayette area Business Briefs for July 9, 2017 – The Advocate

LSU AgCenter plans nitrogen fertilizer event

The LSU AgCenter will host the 15th Annual Nitrogen Use Efficiency Conference on Aug. 7-9 at the Lod Cook Hotel and Conference Center, 3848 W Lakeshore Drive, Baton Rouge.

The meeting is designed for individuals from academic institutions and agricultural companies. Focusing on the use of nitrogen fertilizer, presenters will include representatives from the LSU AgCenter, Auburn University, Oklahoma State University, Kansas State University, the University of Arkansas, and Agriculture and Agri-Food Canada.

Register online at http://bit.ly/2rIpzZL at no charge.

Keep Louisiana Beautiful will hold its 14th annual state conference and Everyday Heroes Awards Banquet on Sept. 20-21 in Baton Rouge.

The event includes information on the impact of litter on the state economy, natural resources and public safety, and provides resources for establishing beautification programs and environmental education.

Topics include how to become a zero-waste family; creating a successful wildflower program; overcoming nature deficit disorder; marketing to millennials; establishing a citywide Christmas tree mulching program; environmental education; volunteer recruitment; Louisiana Recycling Coalition; and behavioral change and modification.

Exhibit opportunities are available. Registration is $125. To register, view conference details or nominate an individual or group for an Everyday Heroes Award, go to http://www.keeplouisianabeautiful.org.

LSU Agriculture Center entomologists received $935,000 from the U.S. Department of Agriculture National Institute of Food and Agriculture to study honeybee health.

The AgCenter is one of seven universities to receive part of $6.8 million the USDA is investing in pollinators.

Kristen Healy and Daniel Swale are conducting research on how stress factors affect honeybees. They are working with researchers at the USDA Honey Bee Breeding, Genetics and Physiology Research Unit in Baton Rouge and the largest beekeeper in the country to do a two-year study following 400 hives.

Healys work focuses on mites and the pathogens they transmit. Swale is studying the physiology of bees, which could suffer from relocations.

The grant includes an extension component so the researchers can determine the best methods to get bee health information to beekeepers and the public.

The USDA estimates honeybees pollinate $15 billion worth of crops.

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Baton Rouge, New Orleans, Lafayette area Business Briefs for July 9, 2017 - The Advocate

Screening technology used for humans a success for Sherbert the horse – Cornwall Live

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In July 2016, dressage competitor Sherbert the horse was having subtle and occasional lameness issues which owner Libby Gill said was "frustrating" because "one day, or literally one minute he would be fine, the next he would feel lame".

Lameness is an abnormal stance of an animal, usually caused by pain or a mechanical dysfunction. Sherbert suffered from it so badly during a competition at the Badminton Championships last year, that Libby and him were unable to continue despite the lameness being random.

Vets were unable to diagnose Sherbert because, when taken to the vet, he was not appearing lame. Libby was told she had to make Sherbert lame before the vet was able to help, but this was impossible as the lameness would occur on a random basis.

After a chance conversation with a friend Libby heard about Sync Thermology. A type of physiological screening that has been successful for humans for ten years and developed into a service that is accessible for use in veterinary medicine.

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Libby, from Truro, contacted Louisa Jenkins, from Camborne, the Cornwall technician for Sync Thermology.

"Thermography is essentially a test of physiology," Louisa said. "It measures the sympathetic nervous response and detects physiological abnormalities and inflammatory responses."

After consulting the vet Libby took Sherbert to Louisa, who has screening facilities in her yard with medically graded cameras also used on humans.

Louisa Jenkin, Cornwall technician for Sync Thermology.

"I took Sherbert to Louisa's yard as she has the proper facilities there to do it, and it only took about an hour and a half in total from start to finish," Libby said.

"I got the report back really quickly and it identified a few things for us to investigate. I am really pleased my friend mentioned this service to me as without it I might still be going around in circled trying to get to the bottom of it all."

Louisa said she screened Sherbert before and after letting him move around so the screen would show the physiological differences before and after work.

"You see the images and then send them through to our team of vets who interpret the images," Louisa added. "They are also trained in thermography and have interpretation software."

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The interpretation software allows the vets to pinpoint areas of distress or increased blood flow to certain areas of the animals.

She said pinpointing certain areas has helped vets in the past discover hairline stress fractures related to the area of increased blood flow in the animal.

Sync Thermology has been used on dogs, giraffes and other animals in the zoo. "There are technicians all over the country," Louisa said. "So it's pretty much a national coverage."

Louisa said this service was popular because of the little harm it brings to animals and the fact it is the only form of physiological screening which assists vets in pinpointing a problem.

After taking Sherbert to Louisa and having his issues resolved through the screening, the pair have since had a very successful Winter Dressage Championship in Hartpury in April this year. They were placed fourth in the Preliminary Area Festival Final.

"It was such a great weekend and fantastic experience," Libby said. "Sherbert was really on form and pulled it out of the bag just at the right time, I'm delighted."

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Screening technology used for humans a success for Sherbert the horse - Cornwall Live

Baum named chair of APS Nutrition Physiology Research Interest Group – Newton County Times (subscription)

FAYETTEVILLE Jamie I. Baum, assistant professor of nutrition for the University of Arkansas System Division of Agriculture, has been named chair of the of the Nutrition Physiology Research Interest Group for the American Physiological Society.

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Baum named chair of APS Nutrition Physiology Research Interest Group - Newton County Times (subscription)

Kinesiology professor earns distinguished lectureship award from the American Physiological Society – Manhattan Mercury (subscription)

David C. Poole, professor of exercise physiology and co-director of the Cardiorespiratory Exercise Laboratory in the kinesiology, and anatomy and physiology departments, will receive the Edward F. Adolph Distinguished Lectureship Award from the Environmental and Exercise Physiology, or EEP, section of the American Physiological Society.

The award and lecture will be presented at the Experimental Biology meeting in San Diego in April 2018. The award recognizes an eminent research scholar who has made meritorious contributions to the areas of environmental, exercise, thermal or applied physiology and who also is an outstanding public speaker.

Pooles research examines the limitations in the oxygen transport pathway especially at the muscle microcirculatory level. This work has been funded by the National Institutes of Health for more than 20 years. Discoveries made by Poole and his colleagues and students have helped inspire and drive major clinical trials advancing novel therapeutic treatments to reduce morbidity and mortality in heart failure patients in the U.S. and worldwide. This work also is germane to understanding the limitations to athletic performance and the exercise intolerance that develops with aging. He has authored three books and numerous chapters in major academic textbooks and regularly presents his work before national and international scientific audiences.

Poole began his higher education in England, where he earned his bachelors degree with honors in applied physiology and sports science from Liverpool Polytechnic. His masters degree and doctorate are from University of California, Los Angeles in kinesiology specializing in physiology. He was awarded the higher Doctor of Science in physiology from John Moores University in Liverpool, which recognized his outstanding contributions to the field. He was the first recipient of that award, which was conferred by the British first lady, Cherie Booth Blair.

Pooles career is filled with recognition and awards in grants, for research and, most importantly, for his teaching and research with students. He is extensively published with more than 200 peer-reviewed papers in journals such as Circulation Research, Journal of Clinical Investigation, Respiration Physiology and Neurobiology, European Journal of Applied Physiology, American Journal of Physiology and the Journal of Applied Physiology. This work has been cited more than 14,000 times in the scientific literature as well as featured on television, newspaper articles and syndicated radio networks.

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Kinesiology professor earns distinguished lectureship award from the American Physiological Society - Manhattan Mercury (subscription)

Department of Physiology

The Department of Physiology has a long-standing tradition of excellence. Our faculty, trainees, and staff seek to understand how the human body works from the head down to the toes and everything in between. Together, we exploit the range of available model systems to understand physiological processes at a mechanistic and integrated level in health with the explicit goal of understanding human disease and identifying potential therapeutics.

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Department of Physiology

Medical Physiology – 9781455743773 | US Elsevier Health Bookshop

I Introduction

Chapter 1 Foundations of Physiology

II Physiology of Cells and Molecules

Chapter 2 Functional Organization of the Cell

Chapter 3 Signal Transduction

Chapter 4 Regulation of Gene Expression

Chapter 5 Transport of Solutes and Water

Chapter 6 Electrophysiology of the Cell Membrane

Chapter 7 Electrical Excitability and Action Potentials

Chapter 8 Synaptic Transmission and the Neuromuscular Junction

Chapter 9 Cellular Physiology of Skeletal, Cardiac, and Smooth Muscle

III The Nervous System

Chapter 10 Organization of the Nervous System

Chapter 11 The Neuronal Microenvironment

Chapter 12 Physiology of Neurons

Chapter 13 Synaptic Transmission in the Nervous System

Chapter 14 The Autonomic Nervous System

Chapter 15 Sensory Transduction

Chapter 16 Circuits of the Central Nervous System

IV The Cardiovascular System

Chapter 17 Organization of the Cardiovascular System

Chapter 18 Blood

Chapter 19 Arteries and Veins

Chapter 20 The Microcirculation

Chapter 21 Cardiac Electrophysiology and the Electrocardiogram

Chapter 22 The Heart As a Pump

Chapter 23 Regulation of Arterial Pressure and Cardiac Output

Chapter 24 Special Circulations

Chapter 25 Integrated Control of the Cardiovascular System

V The Respiratory System

Chapter 26 Organization of the Respiratory System

Chapter 27 Mechanics of Ventilation

Chapter 28 Acid-Base Physiology

Chapter 29 Transport of Oxygen and Carbon Dioxide In the Blood

Chapter 30 Gas Exchange in the Lung

Chapter 31 Ventilation and Perfusion of the Lungs

Chapter 32 Control of Ventilation

VI The Urinary System

Chapter 33 Organization of the Urinary System

Chapter 34 Glomerular Filtration and Renal Blood Flow

Chapter 35 Transport of Sodium and Chloride

Chapter 36 Transport of Urea, Glucose, Phosphate, Calcium, Magnesium, and Organic Solutes

Chapter 37 Transport of Potassium

Chapter 38 Urine Concentration and Dilution

Chapter 39 Transport of Acids and Bases

Chapter 40 Integration of Salt and Water Balance

VII The Gastrointestinal System

Chapter 41 Organization of the Gastrointestinal System

Chapter 42 Gastric Function

Chapter 43 Pancreatic and Salivary Glands

Chapter 44 Intestinal Fluid and Electrolyte Movement

Chapter 45 Nutrient Digestion and Absorption

Chapter 46 Hepatobiliary Function

VIII The Endocrine System

Chapter 47 Organization of Endocrine Control

Chapter 48 Endocrine Regulation of Growth and Body Mass

Chapter 49 The Thyroid Gland

Chapter 50 The Adrenal Gland

Chapter 51 The Endocrine Pancreas

Chapter 52 The Parathyroid Glands and Vitamin D

IX The Reproductive System

Chapter 53 Sexual Differentiation

Chapter 54 The Male Reproductive System

Chapter 55 The Female Reproductive System

Chapter 56 Fertilization, Pregnancy, and Lactation

Chapter 57 Fetal and Neonatal Physiology

X Physiology of Cells and Molecules

Chapter 58 Metabolism

Chapter 59 Regulation of Body Temperature

Chapter 60 Exercise Physiology and Sports Science

Chapter 61 Environmental Physiology

Chapter 62 The Physiology of Aging

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Medical Physiology - 9781455743773 | US Elsevier Health Bookshop

Can Breathing Like Wim Hof Make Us Superhuman? – Discover Magazine (blog)

(Credit: Innerfire BV)

Take a deep breath. Feel the wave of nitrogen, oxygen and carbon dioxide press against the bounds of your ribcage and swell your lungs. Exhale. Repeat.

Before consciously inhaling, you probably werent thinking about breathing at all. The respiratory system is somewhat unique to our bodies in that we are both its passenger and driver. We can leave it up to our autonomic nervous system, responsible for unconscious actions like our heartbeat and digestion, or we can seamlessly take over the rhythm of our breath.

To some, this duality offers a tantalizing path into our subconscious minds and physiology. Control breathing, the thinking goes, and perhaps we can nudge other systems within our bodies. This is part of the logic behind Lamaze techniques, the pranayamic breathing practiced in yoga and even everyday wisdom just take a deep breath.

These breathing practices promise a kind of visceral self-knowledge, a more perfect melding of mind and body that expands our self-control to subconscious activities. These may be dubious claims to some.

For Wim Hof, a Danish daredevil nicknamed The Iceman, it is the basis of his success.

Now approaching his 60s, Hof has run marathons barefoot and shirtless above the Arctic Circle, dove under the ice at the North Pole and languished in ice baths for north of 90 minutes all feats that he attributes to a special kind of breathing practice.

You can easily try it for yourself. While sitting in a comfortable place, take 30 quick, deep breaths, inhaling through your nose and exhaling through your mouth. Then, take a deep breath and exhale; hold until you need to breathe in. Inhale again, as deep as you can, and hold it for 10 seconds. Repeat as many times as you like.

Combined with repeated exposure to the cold, Hof says that his method will lead to tangible health benefits: more energy, lowered stress levels and an improved immune system. For him, it enables seemingly superhuman feats of endurance, brought on, he says, by the physiological changes that his breathing techniques impart.

(Credit: Innerfire BV)

Breathe properly, Hof claims, and oxygen levels in the tissues increase and adrenaline floods the body, granting strength that we didnt know we had.

If you oxygenize the body the way we do it, the oxygen gets into the tissue. [Regular] breathingdoesnt do that, he says. What happens in the brain stem, the brain says, There is no oxygen anymore. Then it triggers adrenaline to shoot out throughout the body. Adrenaline is for survival, but this time it is completely controlled the adrenaline shoots out throughout the body and resets it to the best functionality.

Hof speaks convincingly of the heightened mind-body connection his technique engenders, begging comparisons toa long tradition of semi-mystic practices such as pranayamic yoga, tummo breathing and breathwork.

Over the phone, Hof is loquacious and utterly convincing, perhaps fitting for a man who ran up Mt. Everest shoeless and shirtless, trusting only his breath. He touts the multiple scientific studies hes been involved with, while tossing mentions of mitochondrial activity, blood alkalinity and adrenaline in a flurry of scientific buzzwords.

Above all, he speaks of a more profound connection between mind and body that allows us to quell the primal desire to run from pain and fear or from the cold.

I found by deeper breathing, going into the cold, thinking about it, dealing with it; getting the conviction that my ability to breathe deeper is making connections with my body, he says. If you go into the ice cold you have to go deep. There is no other way. It is just bloody cold.

This mindset aligns with the core tenets of yoga and other practices that aim to grant us more control of our physiology. Breath control is at the center of many of these techniques, and the concept has worked its way into modern medicine as well.

Robert Fried is a clinical respiratory psychophysiologist who retired from the Biopsychology and Behavioral Neuroscience Program at the City University of New York in 2010. Hes also written several books on how breathing is related to stress levels and our physiology. In his practice, Fried worked with individuals whose medical conditions made it difficult to breathe, such as COPD patients, as well as people whose lives or professions left them chronically stressed, and his methods essentially involve

The purpose of deep breathing is to induce a hypometabolic state, where autonomic and mental arousal are minimal.It is a resting, restorative state, a counter anxiety, counter stress response of the body induced by using the breathing that goes with relaxation to trigger a similar muscle response in the body, Fried wrote in an email to Discover.

Its slowing us down, in other words, to counteract the damaging effects that prolonged stress can have on our bodies effects that are well known and generally accepted. Fried and therapists like himhave used conscious breathing techniques, similar to those found in yoga, for years, and have achieved reliable success. Fried mentions that many of his patients felt rejuvenated after just a few minutes of conscious breathing with him, which sounds similar to what Hof promises.

(Credit: Innerfire BV)

We can achieve noticeable physical effects with other breathing exercises as well, although they are almost all short-term. The valsalva maneuver, which involves exhaling while closing the throat, quickly lowers blood pressure and raises the pulse, and is used to help stabilize patients suffering from heart arrhythmias. The Lamaze breathing used by many pregnant women has been shown to increase pain tolerance and aid relaxation, while there have been many reports of hallucinations and feelings of euphoria following hyperventilation.

Despite the daredevil publicity stunts and enthusiastic salesmanship, perhaps Hof isnt so far outside of the norm after all. Perhaps we should simplyview his techniques as radicalized version of yoga, albeit one thats practiced in the middle of a Scandinavian winter.

Still, sitting in an ice bath for an hour and a half is nothing to scoff at. But can we really attribute extreme feats of endurance to the kind of simple exercises we can do while sitting at the office?

The crux of the issue may come down to the question of how well we truly understand the inner workings of the human body. And, though he may edge into hyperbole while discussing myriad benefits of his techniques, Hof has also proven willing to offer himself up as a scientific test subject.

The first true scientific evaluation of Hof came in 2014, when a team led by Danish researcher Mathijs Kox tested the immune systems of people who had followed Hofs training regimen for 10 days. Kox injected participants with an inflammatory agent while they performed the techniques. Compared to a control group, they experienced lower levels of inflammation, and were less affected by the fever and nausea that usually accompanies the injection.

While the researchers still have no solid theory as to why breathing and cold exposure seem to dampen immune activity, they suggest that the release of adrenaline breathing sparks could play a role. The spike in adrenaline was linked to increased levels of an anti-inflammatory protein, and decreased levels of proteins, called cytokines, responsible for signaling the immune system.

Hof being tested. (Credit: Innerfire BV)

There are a few caveats to the study, however. For starters, Koxs team hasnt yet tested the different components of the Hof technique separately, so its hard to say if hyperventilation, breath holding, cold exposure or some combination of all three is at play. In addition, Daniel Beard, a professor of physiology at the University of Michigan points out that their study fails to determine whether the effects are short- or long-term.

None of these people have control over their blood pH or their breathing, except when theyre actually consciously doing this thing. Their heart rates are the same as the other subjects, their pressures are the same, he says.In other words, the life-altering physiological changes that Hof claims exist could only materialize for the short time during which participants are actively doing the exercises.

A true test of the Hof method would determine whether its effects persist, even when people arent consciously altering their breathing. Beard does agree with their fundamental conclusions though, and acknowledges that something is indeed going on in people following Hofs method.

Clearly these people have altered their physiological state this training has changed them, and its changed them in a way that has to do with the autonomic nervous system, he says.

The study lends scientific credibility to Hofs claims and adds credence to the idea that conscious breathing can allow us to influence deeper processes in our bodies. As is perhaps to be expected, Hof goes one step further, positing that the surge in blood alkalinity that accompanies hyperventilationallows us to consciously train our cells, and, theoretically, optimize their machinery. Neurotransmitters in our blood vessels communicate with our brains and cells to regulate blood pH levels something that normally occurs without any intervention on our part. Hof believes that by taking control of our breath we can force open a doorway into these normally unconscious processes and hijack them to optimize how our bodies perform.

This is a more controversial proposition, given that trying to alter blood pH is essentially pitting us against ourselves. When our blood becomes alkaline it violates homeostasis, the perfect balance of internal conditions that our bodies strive to achieve. Hof says this is a good thing. Modernity has made us soft, he asserts, and instead of becoming healthier weve instead achieved a kind of degeneracy. Dunking ourselves in icy waters and breathing like were being chased by a starving tigerbrings about a body more in union, he says, and claims this translates to real health benefits.

(Credit: Innerfire BV)

This is where Hof begins to step beyond the edges of modern science into the cold, as it were. There is really no evidence to suggest making blood alkaline, even temporarily, is a good thing, andresearchers like Fried were skeptical about the possible benefits. The veracityof other physiological mechanisms Hof claims, such as oxygenating the blood and stimulating the immune system with cold are also unproven.

How then should we reconcile Hofs feats with the apparent flaws in his logic? A cynical read says that hesan unnaturally gifted individualexaggerating the limits of normal human physiology to profit from hopeful individuals. But, science wouldnt get very far if it was dominated solely by cynics. Is it possible that Hof has stumbled across a quirk of human physiology, one with with the potential to illuminate previously unseen pathways within our bodies?

Count Andrew Huberman in as one of the optimists.An associate professor of neurobiology and opthamology at Stanford University, Huberman is currently conducting a study that exposes practitioners of Hofs method to fearful encounters via virtual reality to see if their minds and bodies respond any differently.

His research focuses on how our bodies react to stressful situations, and after stumbling across the Wim Hof method a few years ago, Huberman set out to attempt a scientific exploration of the technique. Hes taken courses from Hof himself, and he says the experience convinced him that the breathing techniques were worth a closer look.

Huberman makes it clear that he has no financial ties to Hof, although he has lectured with him. He is, however, an enthusiastic practitioner of the breathing techniques he does them every morning, he says and has developed a theory to explain the calming and mildly euphoric sensations that result. The essence of the techniques, Huberman says, is inoculating our bodies against the stress response. And, as before, adrenaline is the key.

Normally, when adrenaline goes up cortisol goes up too and the hypothesis that were testing is that when you do this method, what ends up happening is you get an increase in adrenaline, but that cortisol, because youre in conscious control of your state, youre remaining calm, cortisol stays relatively low, he says.

From his own experiences, Huberman thinks that the use of hyperventilation and controlled breath-holding maximizes the beneficial effects of our innate stress response, while suppressing the negative long-term effects of stress.

This is a highly unusual situation. Youre kind of uncoupling the normal parallel response of these two hormone neurotransmitters, he says.

Instead of eliminating stress entirely, Huberman thinks that we can learn to twist it to our advantage and condition our bodies to respond in a positive way.

Hes in the early stages of research at the moment, and his project includes a wide-ranging collaboration with other researchers to test a full spectrum of physiological responses. His goal is to perform the kind of testing that will stand up to the intense scrutiny that Hofss claims inevitably provoke.

Key for Huberman will be separating myth from fact. Some breathing techniques common to yoga and lamaze may not confer any benefits for our bodies, and could in fact harm them, according to Fried. Breathing often comes as part and parcel of a larger set of practices, and separating it into its constituent parts can be difficult.

The ultimate goal, says Huberman, is to come up with even better breathing protocols than already exist by examining a range of established practices. Breaking various methods apart to see what works and what doesnt is simply good science.

Indeed, the initial results of the Kox study may indicate that Hubermans adrenaline-cortisol theory may not be totally correct. They found that Hofs cortisol levels actually spiked during their tests, as opposed to dropping as Huberman predicted they should. They didnt confirm similar results in their other test subject though, so the correlation remains ambiguous. In fact, all we can really sayat this point is that this kind of breathing helps release adrenaline into our bodies.

The perplexing power that breathing holds remains a mystery for the time being, even as the quantitative might of the scientific method is brought to bear upon it. Promising research is ahead, however, and Hof and others already hint at the possible rewards.

These studies might end up confirming once and for all what practitioners of yoga and other physical and mental practices have known intuitively for years. It may be that the duality of breath at once automatic and controllable runs even deeper. Its not just our lungs that we can consciously grasp hold of, its our physiology as a whole.

All we have to do is find the handle.

[Disclaimer: Neither Discover Magazine nor any of the researchers interviewed here endorse the Wim Hof method. If you choose to follow the breathing protocols, you do so at your own risk]

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Can Breathing Like Wim Hof Make Us Superhuman? - Discover Magazine (blog)

Taking A Second Look – ChicagoNow (blog)

By Jack Spatafora, Thursday at 10:21 am

The good news is that in this Internet age you and I will never have to be alone again. Or maybe when you think about it, this is actually the bad news. However you choose to think about it, being alone can be debated; but being lonely cannot. Loneliness is a killer.

C.S. Lewis put it best when he said: "Friendship is born in that moment when one person says to another: "What? You too? I thought I was the only one." Marcel Proust then completed the thought: "Let us be grateful to people who make us happy; they are the charming gardeners who make our souls blossom."

As is usually the case, some of us my age are perfectly willing to go with the solid insights of our best writers like Lewis and Proust. These, though, are very different times; now we seem to require additional scientific evidence. Not to worry -- a thousand neurobiologists to the rescue!

We are not saying science has no say in the matter of loneliness. But we are saying it needn't hog the show with its physiological data; for you see my physiology is not me anymore than I am my physiology. Take a recent scientific article in 'The New Republic' by Judith Shulevitz which observes: "We've known intuitively that loneliness hastens death; but haven't been able to explain how. Now we can show that loneliness sends misleading hormonal signals, rejiggers the molecules on genes that govern behavior, and wrenches a slew of other systems out of whack."

To know this much is to know this much. Although it alone is hardly to know loneliness. For the total tragedy of that experience you need more than even our most exquisite scientific explanations. You need to bury a spouse or a child or a parent. Or to travel the anguish in tales from 'The Odyssey' to 'Anna Karenina' to 'Look Homeward Angel.' Or to sing late into the night sad songs like 'My Old Kentucky Home,' 'My Buddy,' and 'Bridge Over Troubled Waters.'

Human loneliness is a feeling and feelings transcend physiology. If they don't, then you and I are simply the synergy of our complex body parts. Something this confirmed theist refuses to believe. And you....?

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Taking A Second Look - ChicagoNow (blog)

DNA testing – on the road to regenerative medicine – VatorNews

We recently had Dr. Craig Venter speak at our Splash Health 2017 event. Dr. Venter is the first person to sequence a human genome, simply put: the instructions and information about human development, physiology, and evolution. In his interview, he points out that 15 years ago, sequencing a human genome would have cost $100 million and take over nine months.

Oh how far weve come. Today, there are a number of companies helping us to analyze our genes, or basically our DNA, which make up genes, to understand our physiology. Advances in sequencing the human genome have been the foundation for this knowledge, and is ultimately paving the path toward personalized medicine - therapies that are personalized to a persons genetic code, and its cousin regenerative medicine - therapies that replace or enable damaged cells, organs to regenerate.

One company, Orig3n, is doing both. Boston-based Orig3n started out in 2014 collecting blood samples to conduct regenerative medicine studies, but later added in the ability to conduct DNA testing to learn more about a persons intelligence, or predisposition to learning languages, to knowing what vitamins theyre deficient in.

Its an interesting an unique funnel the company has created for itself on its way to solve big problems with regenerative medicine, which seems more in its infancy than DNA testing.

To that end, Orig3ns DNA testing business has taken off.

In order to be tested, you take a cotton swab and swab the inside of your cheek to collect DNA samples from the cells inside your mouth. Alternatively, one could spit in a tube, which is how 23andMe collects samples of DNA.

From there, Orig3n breaks down the cells to open up the DNA, which is inside the nucleus of the cell. The DNA is then purified and put into a genetic test panel. Your DNA is then analyzed against other DNA that have been collected and studied.

The analysis of the DNA is pretty standard. What differentiates its products, according to Robin Smith, Founder and CEO, is how the analysis is packaged and how quickly the results are turned around. The whole genome sequencing world has been around for 15 years and is fairly commoditized, said Smith. The same thing is happening with DNA detection. The biggest differentiator for Orig3n is that it delivers the data in ways that are understandable, said Smith.

For instance, on Orig3n, tests focus on an analysis of your skin to perfect your skincare routine, or about your strength and intelligence. Tests range from $20 to $100.

On Everlywell, you can take a DNA test to measure your sensitivity to foods. Or for around $239, it appears you can test to see if you have HIV, Herpes Type 2 and other sexual diseases.

On 23andMe, you can pay $199 to learn what proportion of your genes come from 31 populations worldwide, or what your genetic weight predisposes you to weigh vs an average and what are some healthy habits of people with your genetic makeup [though personally these habits seem to be good for anyone regardless of genetic makeup].

But for Orig3n, the DNA tests are just a good business while also a funnel to the bigger problem theyre trying to solve, and for which they recently raised $20 million for: Regenerative medicine.

Before offering the DNA tests, Orig3n was taking and continues to take blood samples, reprogramming cells to go back to a state three days prior. And from there, they can grow certain tissues. The purpose of Orig3n is to create cell therapies for various diseases and disorders.

In the next fives year, there will be real live therapies to repairing the degeneration of your eyes or performing some cardiac repair, Smith predicted. It feels like 1993 when I used a phone line to dial into the Internet, then seven years later we had the boom. We think regenerative medicine - getting your body to induce itself to rejuvenate parts that are broken - is where the Internet was in 1993.

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DNA testing - on the road to regenerative medicine - VatorNews

Welcome to University Of Botswana :: Job Opportunities … – University of Botswana

Last Date of Apply : 19.07.2017

Date of Posting : 04.07.2017

Faculty / Department : Faculty of Medicine

Job Detail:

TECHNICIAN (PHYSIOLOGICAL AND/OR MICROBIOLOGICAL SCIENCES) VACANCY NO. IRC 721

Duties: The successful applicant will be expected to work in Human Physiology and/or Microbiology laboratories under the tutelage of the physiology and/or microbiology teams, ensuring that laboratories are effectively managed, serviced and maintained. The successful candidate will be expected to (i) Manage the human physiology and microbiology laboratories and other sections under their area of responsibility (ii) manage and service laboratory equipment (iii) instruct users in the correct use of equipment (iv) maintain stocks of consumables (v) liaise with researchers, academic staff and chief technician on the procurement of equipment and materials (vi) maintain a safe working environment in the areas of responsibility (vii) mentor junior technical staff.

Requirements: Applicants must have (i) at least a Diploma or Degree in the relevant field and at least two years experience post qualification experience in a technical role in a human physiology/microbiology or related laboratory. They should demonstrate good technical, administrative and supervisory skills and familiarity with IT.

How to Apply:

Applicants should address the stated qualifications and provide any other information to assist the University to determine your suitability for the position. They should quote the vacancy number of the post applied for, provide current CVs (including telephone and telefax numbers, and e-mail), certified true copies of educational certificates and, names, addresses and contact details of three referees. Applicants should inform their referees to (i) quote the vacancy number (ii) position applied for, and (iii) submit their references directly to the address stated below before the stipulated closing date. Send your application to: The Human Resources Manager, Faculty of Medicine, Private Bag UB 00713 Gaborone, Botswana. Tel. (267) 355 2884 Fax (267) 355 4738. E-mail to kgomotso.maribe@mopipi.ub.bw or boikanyego.otumiseng@mopipi.ub.bw

Hand delivered applications should be submitted to Office No. UB Academic Hospital at 3rd Floor, Block F Office 4003 or 4004.

NB: Only shortlisted applicants will be contacted.

CLOSING DATE: 19 JULY 2017

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Welcome to University Of Botswana :: Job Opportunities ... - University of Botswana