Category Archives: Physiology

RET Alterations in Advanced NSCLC – OncLive

Stephen Liu, MD: RET does have a normal role in physiology. RET stands for rearranged during transfection, and it encodes a transmembrane receptor tyrosine kinase, which is important for the development of neurons. Particularly the enteric nervous system development of a lot of nerve signaling pathways. Its primary role in normal physiology is in the development of the gut, the enteric system, and the kidney.Mark A. Socinski, MD: RET alterations have been known since the 1980s. Ive personally been involved with lung cancer programs that have tested for RET alterations for a decade or so. The frustration was that we didnt have good selective RET inhibitors prior to the recent approval of pralsetinib and selpercatinib, which are highly active RET drugs. RET fusions, like ALK fusions, ROS1 fusions, and NTRK fusions, become oncogenic drivers. They turn on the growth pathway, survival pathways, and give the cancerous cells an advantage over the normal cell population, leading to uncontrolled proliferation, which is one of the hallmarks of cancer.

Ben Levy, MD: We now have data that shows RET has multiple fusion partners. In fact, theres more than 40 unique fusion partners for RET, when we talk about RET fusions in lung cancer, and particularly other solid tumor cancers, like thyroid. Most importantly, the most common RET fusion partner is the KIF5B fusion partner. This is the one that we saw most commonly in both the selpercatinib data and the pralsetinib data, but there are other fusions that have been seen. CCDC6 and NCOA4 are also fusion partners that can be identified. Clearly, its important to make sure that you have a fusion. When youre looking at a next-generation sequencing report, its not a RET mutation that predicts sensitivity to these new FDA-approved therapies, its the fusion. So yes, you can look at the fusion partner and see what it is, but I think were still trying to learn whether the type of fusion partner predicts efficacy to selpercatinib and pralsetinib. I think we know that the RET fusion partner, KIF5B, does predict efficacy to both pralsetinib and selpercatinib. But fusions arent mutations. When youre getting a next-generation sequencing report, make sure its the fusion. And then yes, of course you can look at the partner. But did they tell a different story? Thats important to understand.

Transcript edited for clarity.

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RET Alterations in Advanced NSCLC - OncLive

NFF: Coaching course will take us back to 1994 era, says Okoson – Punch Newspapers

Published 30 October 2021

Robinson Okoson, the Deputy Director technical and Head Psychology unit of the Nigeria Football Federation (NFF) on Friday said coaching courses will help to take Nigeria back the golden era of 1994.

Okoson told journalists at the end of a five-day coaching course that the training course was targeted at the train the trainers.

He said the name of the course entitled Elite Instructor Coaches Course, will take Nigeria back to the golden era where a lot of football physiology was found in every club and players will play the same pattern.

The News Agency of Nigeria reports that the coaching course was organised by the NFF in collaboration with the Confederation of African Football (CAF).

Okoson said 32 coaches participated in the course, saying that coaches were selected randomly from all the 36 states, including Abuja.

We came up with this programme that will enhance the quality of our coaches which will help us on the quality of play in the league and help all our players generally.

The training covers their physiology, tastics and technical aspects of the game, he said.

He said in the nearest future, Nigeria will start to reap the results of the training.

These coaches trained, will go to grassroots to impart what they have learnt.

In the nearest future let say six to ten years we will be reaping the results of what we just did in terms of bringing out players across the country in a physiology way, he said.

He said they will also organise the CAF A and CAF B license course.

We are also going to do another programme where we will also bring another set of Coaches.

We have a lot of other coaches in Nigeria we want to put a stop to all these academies that are just springing up here and there, Academies that dont really have access to the level of coaching we have, he said.

NAN reports that the five-day Elites Instructor Coaches Course which started on Monday ended on Friday (NAN)

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NFF: Coaching course will take us back to 1994 era, says Okoson - Punch Newspapers

Mot Hennessy pledges to reduce its carbon footprint and invest in sustainability – decanter.com

Mot Hennessy, the wine and spirits division of leading luxury goods group Mot Hennessy Louis Vuitton (LVMH), has issued a pledge to reduce its carbon footprint by adopting the 1.5C target, as stipulated under the Paris Agreement and confirmed by the Science Based Targets initiative partnership (SBTi).

As part of the pledge, Mot Hennessy is committed to reduce its greenhouse gas emissions by 50% in absolute value by 2030 (compared to 2019 figures) by focusing on four core areas: reduce its raw materials carbon impact, develop eco-conscious packaging, leverage renewable energy, and promote low-carbon transportation.

We believe we have an important responsibility alongside the wines and spirits industry to significantly reduce our carbon footprint throughout the value chain, while developing biodiversity in our regions, said Mot Hennessy CEO, Philippe Schaus. We have set ambitious goals that we are committed to following regularly and integrating into Mot Hennessys overall strategy.

The announcement follows a series of sustainable viticulture initiatives released as part of Mot Hennessys Living Soils Living Together programme. Last week, the business inaugurated its new Robert-Jean de Vog Research Centre near its Mont Aigu winery in Oiry, Champagne. The centre, which cost the group some 20m (17m), is dedicated to advancing knowledge of future environmental and production challenges, tackling climate change, and to developing sustainable winemaking practices.

Faced with the two main environmental challenges of climate change and the loss of biodiversity, Mot Hennessy has structured all of its actions in its Living Soils Living Together programme, our social and environmental commitment, Mot Hennessy chief sustainability officer, Sandrine Sommers told Decanter. We have set ourselves ambitious goals for 2030 To support this we need research, innovations and new solutions and our new [centre] is crucial to meet the challenges of viticulture of tomorrow.

Conceived by architect Giovanni Pace, the new research centre covers an area of 4,000m2 and the building itself is designed to showcase Mot Hennessys commitment to sustainability. It is made from materials that grant natural insulation, which helps reduce energy consumption, and is embedded in a gently sloping earthen embankment to ensure it blends graciously with the surrounding landscape.

Its research efforts will focus on four key areas: a microbiology and biotechnology hub will be dedicated to better understand the impact of microorganisms on vineyards and on the fermentation process, while a further hub will focus on plant physiology, to mitigate the impact of climate change on vines and grapes and tackle the challenges induced by warming temperatures. The plant physiology team will benefit from innovative infrastructures such as climate chambers, which are capable of simulating climate changes in Mot Hennessy vineyards across the globe.

A process engineering hub will be destined to analyse the winemaking process, from pressing to bottling, with the aim to optimise it and to promote recyclability. Lastly, the sensory analysis and formulation hub will focus on studying the organoleptic profile of Mot Hennessy products throughout the different stages of the manufacturing process to maximise wine quality.

The research centre will be a hub for sharing knowledge both between [our] houses and with public sector researchers and will also embrace collaboration with other external structures, said Schaus. Indeed, over 10 partners will collaborate with the centre, including the Comit Interprofessionnel du Vin de Champagne (CIVC), the University of Reims Champagne Ardennes, and Frances National Research Institute for Agriculture, Food and Environment (INRAE de Colmar).

The new centre is named after Mot Hennessy former president and innovator, Robert-Jean de Vog, who contributed to the creation of the CIVC in 1941. Robert-Jean de Vog always thought a quarter-hour ahead, Schaus said. A great figure in the world of wine, he left an indelible impression on his era with his innovative spirit and activities with Maison Mot & Chandon in France and around the world.

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Mot Hennessy pledges to reduce its carbon footprint and invest in sustainability - decanter.com

Ipsen Appoints Stewart Campbell Executive Vice President and President of North America – Business Wire

CAMBRIDGE, Mass.--(BUSINESS WIRE)--Ipsen (Euronext: IPN; ADR: IPSEY) announced today the appointment of Stewart Campbell as Executive Vice President and President of North America, effective immediately. Based in Cambridge, he will lead the business in the US and Canada, continuing to drive Ipsens positive impact for patients. He will report directly to David Loew, CEO, Ipsen and serve on the Executive Leadership Team (ELT).

Stewart brings extensive experience in the pharmaceutical industry which will be instrumental in accelerating Ipsens growth in North America as we continue to strengthen our global footprint and deliver our new group strategy, Focus. Together. For patients and society. We are delighted to welcome him to the ELT, and we look forward to working closely with him, said David Loew, CEO, Ipsen.

Im excited to be appointed as EVP and President of North America at this key moment for Ipsen, said Stewart Campbell. Ive been impressed by the dedication that Ive seen from all of Ipsen as we work together to improve the lives of patients and their families. I am looking forward to helping write the next chapter of our story in North America.

Stewart joined Ipsen as Senior Vice President and Franchise Head of Oncology earlier in 2021 from Roche/Genentech where he spent more than 14 years and was responsible for the lifecycle management of some of Roches oncology blockbusters, including both commercial and clinical development globally. Through a career of more than 20 years in the pharmaceutical industry, Stewart has gained deep experience leading country and global commercial functions in Oncology and Specialty Care markets, including in Canada, Switzerland and the US.

Stewart is a graduate of Concordia University in Montreal, Canada, where he received his B.S. in physiology with a minor in physics. He received an MBA in corporate finance from Queens University in Kingston, Canada and an additional MBA in business strategy from the Johnson School of Management at Cornell University in Ithaca, New York.

Ipsen North America

Ipsen is a global biopharmaceutical company focused on innovation and specialty care. Its resources, investment and energy center on discovering, developing and commercializing medicines in three key therapeutic areas Oncology, Rare Disease and Neuroscience. The Company is dedicated to providing hope for patients whose lives are challenged by unmet medical needs. Ipsens North American operations are located in Cambridge, Massachusetts, one of the Companys three global hubs. For more information, please visit http://www.ipsenus.com.

Forward-looking statements

The forward-looking statements, objectives and targets contained herein are based on Ipsens management strategy, current views and assumptions. Such statements involve known and unknown risks and uncertainties that may cause actual results, performance or events to differ materially from those anticipated herein. All of the above risks could affect Ipsens future ability to achieve its financial targets, which were set assuming reasonable macroeconomic conditions based on the information available today. Use of the words believes, anticipates and expects and similar expressions are intended to identify forward-looking statements, including Ipsens expectations regarding future events, including regulatory filings and determinations. Moreover, the targets described in this document were prepared without taking into account external growth assumptions and potential future acquisitions, which may alter these parameters. These objectives are based on data and assumptions regarded as reasonable by Ipsen. These targets depend on conditions or facts likely to happen in the future, and not exclusively on historical data. Actual results may depart significantly from these targets given the occurrence of certain risks and uncertainties, notably the fact that a promising medicine in early development phase or clinical trial may end up never being launched on the market or reaching its commercial targets, notably for regulatory or competition reasons. Ipsen must face or might face competition from generic medicine that might translate into a loss of market share. Furthermore, the research and development process involves several stages each of which involves the substantial risk that Ipsen may fail to achieve its objectives and be forced to abandon its efforts with regards to a medicine in which it has invested significant sums. Therefore, Ipsen cannot be certain that favorable results obtained during preclinical trials will be confirmed subsequently during clinical trials, or that the results of clinical trials will be sufficient to demonstrate the safe and effective nature of the medicine concerned. There can be no guarantees a medicine will receive the necessary regulatory approvals or that the medicine will prove to be commercially successful. If underlying assumptions prove inaccurate or risks or uncertainties materialize, actual results may differ materially from those set forth in the forward-looking statements. Other risks and uncertainties include but are not limited to, general industry conditions and competition; general economic factors, including interest rate and currency exchange rate fluctuations; the impact of pharmaceutical industry regulation and healthcare legislation; global trends toward healthcare cost containment; technological advances, new medicine and patents attained by competitors; challenges inherent in new-medicine development, including obtaining regulatory approval; Ipsen's ability to accurately predict future market conditions; manufacturing difficulties or delays; financial instability of international economies and sovereign risk; dependence on the effectiveness of Ipsens patents and other protections for innovative medicines; and the exposure to litigation, including patent litigation, and/or regulatory actions. Ipsen also depends on third parties to develop and market some of its medicines which could potentially generate substantial royalties; these partners could behave in such ways which could cause damage to Ipsens activities and financial results. Ipsen cannot be certain that its partners will fulfil their obligations. It might be unable to obtain any benefit from those agreements. A default by any of Ipsens partners could generate lower revenues than expected. Such situations could have a negative impact on Ipsens business, financial position or performance. Ipsen expressly disclaims any obligation or undertaking to update or revise any forward-looking statements, targets or estimates contained in this press release to reflect any change in events, conditions, assumptions or circumstances on which any such statements are based, unless so required by applicable law. Ipsens business is subject to the risk factors outlined in its registration documents filed with the French Autorit des Marchs Financiers. The risks and uncertainties set out are not exhaustive and the reader is advised to refer to Ipsens 2020 Universal Registration Document, available on ipsen.com.

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Ipsen Appoints Stewart Campbell Executive Vice President and President of North America - Business Wire

Stress and the gut: pathophysiology, clinical consequences …

Stress, which is defined as an acute threat to homeostasis, shows both short- and long-term effects on the functions of the gastrointestinal tract. Exposure to stress results in alterations of the brain-gut interactions ("brain-gut axis") ultimately leading to the development of a broad array of gastrointestinal disorders including inflammatory bowel disease (IBD), irritable bowel syndrome (IBS) and other functional gastrointestinal diseases, food antigen-related adverse responses, peptic ulcer and gastroesophageal reflux disease (GERD). The major effects of stress on gut physiology include: 1) alterations in gastrointestinal motility; 2) increase in visceral perception; 3) changes in gastrointestinal secretion; 4) increase in intestinal permeability; 5) negative effects on regenerative capacity of gastrointestinal mucosa and mucosal blood flow; and 6) negative effects on intestinal microbiota. Mast cells (MC) are important effectors of brain-gut axis that translate the stress signals into the release of a wide range of neurotransmitters and proinflammatory cytokines, which may profoundly affect the gastrointestinal physiology. IBS represents the most important gastrointestinal disorder in humans, and is characterized by chronic or recurrent pain associated with altered bowel motility. The diagnostic testing for IBS patients include routine blood tests, stool tests, celiac disease serology, abdominal sonography, breath testing to rule out carbohydrate (lactose, fructose, etc.) intolerance and small intestinal bacterial overgrowth. Colonoscopy is recommended if alarming symptoms are present or to obtain colonic biopsies especially in patients with diarrhoea predominant IBS. The management of IBS is based on a multifactorial approach and includes pharmacotherapy targeted against the predominant symptom, behavioural and psychological treatment, dietary alterations, education, reassurance and effective patient-physician relationship. When evaluating for the stress-induced condition in the upper GI tract, the diagnostic testing includes mainly blood tests and gastroscopy to rule out GERD and peptic ulcer disease. The therapy for these conditions is mainly based on the inhibition of gastric acid by proton pump inhibitors and eradication of Helicobacter pylori-infection. Additionally, melatonin an important mediator of brain gut axis has been shown to exhibit important protective effects against stress-induced lesions in the gastrointestinal tract. Finally, probiotics may profoundly affect the brain-gut interactions ("microbiome-gut-brain axis") and attenuate the development of stress-induced disorders in both the upper and lower gastrointestinal tract. Further studies on the brain-gut axis are needed to open new therapeutic avenues in the future.

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Stress and the gut: pathophysiology, clinical consequences ...

New faculty profile: Joe Pierre studies diet, gut physiology, and the microbiome in health and disease eCALS – wisc.edu

Joe Pierre joined the UWMadison faculty in October 2021 as an assistant professor in the Department on Nutritional Sciences. Funding for this nutrition-focused position comes from the Dairy Innovation Hub, which has supported 11 faculty positions so far at UWMadison, UWPlatteville and UWRiver Falls.

What is your hometown? Where did you grow up?I grew up in Green Bay and Door County, Wisconsin, a little over 2 hours northeast of Madison.

What is your educational/professional background, including your previous position?I attended UWMadison as an undergraduate (BS in natural science) where I was a student athlete in track and cross country from 2005-2008. I then completed a Ph.D. in nutritional sciences through the IGPNS program at UW. Following graduation, my postdoctoral fellowship training was in gastroenterology, hepatology, and nutrition at the University of Chicago. Prior to joining the UW faculty, I was most recently an assistant professor of pediatrics, microbiology, immunology, and biochemistry at the University of Tennessee Health Science Center.

How did you get into your field of research?The gastrointestinal tract serves as the largest external surface of the body and is tasked with digesting and absorbing nutrients, mediating cohabitation with trillions of microorganisms, and acting at the largest endocrine and immune organ. As I learned more about the many important roles the gut plays in human health, I became more fascinated by how diet and resident microbial communities fundamentally shape metabolic and immune responses in the gut and throughout the body. My fellowship training was focused on the tools and concepts for studying the gut microbiome and host metabolites. Putting all these experiences together, it was a natural next step to bring these experiences and interests back to the field of nutritional sciences.

What are the main goals of your current research program?My research program has been centered around understanding the roles of diet, gut physiology, and the microbiome in health and disease. We have existing NIH funding examining the role of diet and bariatric surgery on breast cancer outcomes, the role of the microbiome/mycobiome in inflammatory bowel disease, and how extraintestinal microbial communities (in circulation) shape cardiovascular events. At UW, my program will continue to utilize diverse experimental tools (bariatric surgery, parenteral nutrition, gnotobiotics, microbial sequencing, and enteroids) to gain deeper insights into nutritionally relevant areas emphasizing dairy components in the context of disease treatment, prevention and optimizing human health.

What attracted you to UWMadison? UWMadison is a research powerhouse with thousands of talented faculty colleagues, laboratory resources, core facilities, along with thoughtful and hardworking students and trainees to interact with. If there is a scientific hypothesis worth testing, you can successfully pursue it at the UW.

What was your first visit to campus like?I believe my first visit to campus was as a child (my brother was an engineering student), but I remember touring campus as a high school track recruit with then head coach, Ed Nuttycombe. The impression and beauty of this campus never gets old.

Whats one thing you hope students who take a class with you will come away with?I hope my students are inspired by the materials and concepts and go on to pursue lifelong curiosity outside of the classroom that enriches their lives and professional careers.

Do you share your expertise and experiences with the public through social media? If so, which channels do you use?I am an infrequent user of social media but maintain a Twitter and LinkedIn account.

Do you feel your work relates in any way to the Wisconsin Idea? If so, please describe how.Absolutely. The pursuit of basic and translational research knowledge especially in metabolism, nutrition, and health benefits the residents of Wisconsin and beyond. More specifically, a key emphasis of my program is gaining deeper insights into the use of dairy components and products in human health and nutrition. Milk is a fundamentally important source of nutrition in mammalian biology. Dairy products contain complete protein, hundreds of bioactive peptides and enzymes, and unique lipids that have been key assets to human agriculture and success for millennia. Beyond human health, dairy is economically important to Wisconsin and many populations around the globe.

Whats something interesting about your area of expertise you can share that will make us sound smarter at parties?It may sound clich, but we really are a product of what we eat. Beyond energy, our diets begin an enormously complex cascade of metabolites, microbial adaptation and selection, and host cell and organ system responses that are fascinating and interconnected in many ways that were still trying to understand. Appreciating the catalyzing role of diet synergizes with the biochemical, genetic, environmental, lifestyle and microbiological academic pursuits in understanding human biology.

What are your hobbies and other interests?As a father of several young kids, I spend a lot of time at home, with the occasional camping trip or golf outing.

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New faculty profile: Joe Pierre studies diet, gut physiology, and the microbiome in health and disease eCALS - wisc.edu

This day in history, October 18: James D. Watson, Francis Crick and Maurice Wilkins honored with Nobel Prize for Medicine and Physiology for…

Ten years ago: Fifty wild animals were released by the owner of a Zanesville, Ohio, farm, Terry Thompson, who then took his own life; authorities killed 48 of the creatures, while the remaining two were presumed eaten by other animals. Republican presidential candidates laced into each other in a debate in Las Vegas; Mitt Romney emerged as still the person to beat, even as he was called out on the issues of illegal immigration, health care and jobs. Israeli soldier Gilad Shalit (gee-LAHD shah-LEET) emerged from five years in captivity as Hamas militants handed him over to Egyptian mediators in an exchange for 1,000 Palestinian prisoners.

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This day in history, October 18: James D. Watson, Francis Crick and Maurice Wilkins honored with Nobel Prize for Medicine and Physiology for...

FAIR Institute Introduces FAIR-CAM to Help Cybersecurity Teams Assess Effectiveness of Risk Management Controls to Make More Cost-Effective Business…

An extension of the FAIR model, FAIR Controls Analytics Model (FAIR-CAM), allows analysts to map controls to risk more easily and reliably

RESTON, Va., Oct. 20, 2021 (GLOBE NEWSWIRE) -- The FAIR Institute, a non-profit professional organization dedicated to advancing the discipline of measuring and managing information risk, has launched its FAIR Control Analytics Model (FAIR-CAM), making cyber risk quantification even more useful as a decision support tool. It provides the means to map and account for risk management controls when performing a FAIR analysis, enabling analysts to more accurately measure the risk-reduction value of controls in terms that are accessible to the business.

While most control assessment practices simply express control conditions as ordinal scores (1 through 5, or red, yellow, green), these values are abstract and subjective, as they arent actual units of measurement, like percentages, time, units of money, etc. As a result, control measurements tend to be less reliable, making it difficult for cybersecurity teams to translate control improvements into risk reduction. The FAIR-CAM model addresses this critical knowledge gap.

The FAIR (Factor Analysis of Information Risk) cyber risk model has already emerged as the premier Value at Risk model for cybersecurity and operational risk. To add to this recognized industry standard, the FAIR-CAM controls model will provide these crucial units of measurement for each control function, which means cybersecurity teams can empirically measure the efficacy of controls. And because the FAIR-CAM model overlays its control functions on top of the FAIR model, analysts will be able to determine how much less risk will exist as controls improve (or vice versa).

Whereas FAIR quantifies the frequency and magnitude (in dollar terms) of cyber loss events, the FAIR-CAM model quantifies the effectiveness of controls for reducing that frequency and magnitude. Combining the two enables risk and security organizations to measure the risk reduction value of controls and controls systems more easily and reliably.

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Existing control frameworks or risk scores are lists of individual controls or control objectives. However, none of these frameworks formally define the many ways in which controls directly or indirectly affect risk, explained Jack Jones, president, FAIR Institute. A useful analogy is the difference between the anatomy of a human body, and its physiology. Anatomy is a list of the parts (bones, muscles, nerves, organs, etc.), while physiology is a description of how those parts function both individually and as a system.

"Existing frameworks provide a useful anatomy for cybersecurity controls, and the FAIR-CAM model describes control physiology. It provides the missing link between todays control frameworks and risk measurement. This enables reliable measurement of control efficacy and value, so that organizations make better use of their limited resources to manage cybersecurity and risk.

The FAIR-CAM controls model maps to all the popular controls frameworks, such as NIST, ISO, and CIS, and will help security teams get more value from frameworks. Rather than conducting simple gap analysis, teams can make well-informed choices among the controls recommended by the frameworks, based on quantifiable risk reduction.

The FAIR-CAM controls model goes a long way in connecting the dots within the cyber risk equation. In particular, it will help organizations like Highmark Health take a more practical approach to operationalize cyber risk management by mapping controls to risks. This will enable us to more confidently evaluate controls to determine which ones to grow, sustain or sunset, said Omar Khawaja, CISO, Highmark Health.

About the FAIR InstituteThe FAIR Institute is an expert, non-profit organization led by information risk officers, CISOs and business executives, created to develop and share standard risk management practices based on FAIR. Factor Analysis of Information Risk (FAIR) is the only international standard analytics model for information security and operational risk. FAIR helps organizations quantify and manage risk from the business perspective and enables cost-effective decision-making. To learn more and get involved visit: http://www.fairinstitute.org.

FAIR Institute education partners include Arizona State University, Carnegie Mellon University, Center for Applied Cyber Education, Ferris State University, George Mason University, Harvard University, Macquarie University, Pepperdine, San Jose State University, University of Massachusetts Amherst, University of Tampa, University of Toronto, Virginia Tech, and Washington University in St. Louis.

Media Contact:

Cathy Morley FosterEskenzi PRcathy@eskenzipr.com925.708.7893

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FAIR Institute Introduces FAIR-CAM to Help Cybersecurity Teams Assess Effectiveness of Risk Management Controls to Make More Cost-Effective Business...

GPR39 as a Therapeutic Target in Vascular Cognitive Impairment Dementia – The University of Arizona Health Sciences |

Please join Dr. Nabil Alkayed, Professor of Anesthesiology & Perioperative Medicine, Neurology, Neurological Surgery, Cardiovascular Medicine and Physiology & Pharmacology at Oregon Health & Science University (OHSU) for a presentation over breakfast.

Dr. Alkayeds presentation will review human and experimental evidence for the role of eicosanoid signaling in aging-related cognitive impairment and dementia (VCID), specifically focusing on the role of P450 eicosanoids and the newly discovered G protein-coupled receptor 39 (GPR39). Evidence supporting the role of GPR39 in VCID in humans and animal models sets the stage for therapeutic development and other clinical applications.

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GPR39 as a Therapeutic Target in Vascular Cognitive Impairment Dementia - The University of Arizona Health Sciences |

Does Taking a Hot Bath Really Have the Same Health Benefits as Exercising? – Livestrong

Hot baths offer some of the same benefits as exercise, but they should not replace your workouts.

Image Credit: PRImageFactory/iStock/GettyImages

A rise in body temperature, sweat and heart rate these physical responses are the most common signs of a strenuous aerobic workout. But these same physiological reactions are also strikingly similar to the ones you experience soaking in a hot bath.

That's what the authors of a December 2020 review published in the Journal of Applied Physiology concluded. They also discovered that regular hot baths could offer many of the same health benefits as moderate-intensity exercise.

In fact, one small study in the review found that two months of cycling (three times a week for 30 minutes) compared to the same number of time-matched warm baths produced comparable improvements in cardiorespiratory fitness and vascular health in young sedentary male adults.

But does that really mean you can skip your spin class for some time in the tub and still reap the same benefits? Here, John Higgins, MD, a sports cardiologist with McGovern Medical School at UTHealth in Houston, assesses the benefits of a hot bath and their limits versus exercise.

When compared to moderate-intensity exercise, regular hot baths have many of the same health pluses.

1. They Improve Blood Flow and Blood Pressure

It's well documented that exercise has protective effects on vascular health. But research also points to similar advantages of hot baths.

For example, a June 2016 study in The Journal of Physiology found that eight weeks of regular hot baths helped reduce arterial stiffness and reduced blood pressure in young sedentary adults.

"Hot baths increase blood flow not only to skin but also to other vital organs," Dr. Higgins says. This boost in blood flow promotes the production of more nitric oxide, which keeps the blood vessel walls smooth and prevents inflammation and plaque build-up, he explains.

The increased dilation of blood vessels also leads to a lowering in blood pressure, Dr. Higgins adds.

2. They Increase Your Heart Rate

Just like a brisk jog, stepping into a hot bath will raise your heart rate.

Here's why: A steamy bath causes the blood vessels to dilate and lowers your blood pressure. Consequently, "your heart rate speeds up to compensate," Dr. Higgins says.

Indeed, the same review in the Journal of Applied Physiology found that passive heating (such as taking a hot bath) can increase heart rate between 20 to 40 beats per minute. Still, it's worth noting that this effect is substantially milder compared to the rise that occurs during moderate-intensity exercise.

3. They May Help Reduce Inflammation

Exercise can help curb chronic low-grade inflammation which drives many diseases and there's some evidence that regular hot baths can have a similar benefit.

Hot bathing can decrease inflammatory markers, which may reduce your risk of cardiovascular morbidity and mortality by as much as 25 percent, Dr. Higgins says. But the long-term effects of hot baths on inflammation aren't certain and more research is needed.

4. They Promote Better Blood Sugar Levels

Research has found that just three weeks of daily hot bathing can improve blood glucose levels in people with type 2 diabetes, Dr. Higgins says.

For instance, a July 2015 study in Current Opinion in Clinical Nutrition and Metabolic Care found that heat therapy, such as using a sauna or hot tub, shows some promise in treating type 2 diabetes.

The extreme heat can cause your blood vessels to dilate, which makes your body absorb insulin more quickly and as a result, lower blood sugar levels, according to the Centers for Disease Control and Prevention.

5. They Can Help Boost Mood

Anyone who's ever experienced a runner's high or the feel-good rush of post-workout endorphins can confirm exercise can boost your mood.

Apparently, so can a hot soak. Warm baths may reduce stress hormones and help balance serotonin levels, which play a role in regulating mood, according to the Cleveland Clinic.

In addition, some research shows that bathing in hot water (104 degrees Fahrenheit) for a half-hour can help decrease depression symptoms, per the Cleveland Clinic.

While hot baths may mimic some of the health benefits of exercise, there are certain things they simply can't do. Here are a few:

1. They Dont Build Muscle, Strength or Bone Density

Exercise puts force on a muscle, leading to muscle damage and subsequent repair and growth (as well as increased bone density), Dr. Higgins says.

But you can't build lean muscle and sturdy bones or make strength gains by relaxing in a hot bath. "To build and strengthen muscles, you have to use them," Dr. Higgins says.

2. They Dont Enhance Endurance

Though a hot bath can raise heart rate temporarily, it can't help you sustain physical activity for an extended period. In other words, it won't support your stamina.

To improve your endurance, you must increase the distance, time or difficulty of an exercise, and this does not happen with a hot bath, Dr. Higgins says.

3. They Dont Support Weight Loss

While working out can be part of a healthy weight loss (or weight management) strategy, a steamy soak in the tub won't foster fat loss or lower your BMI.

Case in point: The same Journal of Applied Physiology review found that eight weeks of moderate-intensity cycling reduced body weight whereas hot baths did not. That may be because aerobic exercise burns more than 10 times the calories as passive heating.

When to Take a Hot Bath for the Best Benefits

The best time to reap the benefits of a hot bath is right after a workout, Dr. Higgins says. Thirty minutes in the tub can soothe sore muscles and support muscle recovery and growth.

That's because hot baths improve blood flow, which helps repair and rebuild muscle fibers and reduce inflammation, Dr. Higgins says.

For an even greater bang for your bath buck, add Epsom salts, which can help loosen muscles and alleviate pain, per the Cleveland Clinic. Three hundred grams should do the trick.

For the optimal hot bath benefits, aim to take a hot bath four times weekly and soak for 30 to 60 minutes, Dr. Higgins says.

While there are many benefits of taking a hot bath, they can also dry out your skin. To avoid this, dont soak in steamy water every day. And try these tips:

So, Can Hot Baths Replace Exercise?

"The best way to think about a hot bath is (pardon the pun) like a watered-down version of exercise," Dr. Higgins says. With a hot bath, you get some of the vascular benefits of exercise, but not the major cardiorespiratory or cardiometabolic gains of moving your body.

So, if you only have 30 minutes in your schedule, going for a jog or taking an aerobics class will always be better than 30 minutes of lying in a hot tub, Dr. Higgins says.

In other words, hot baths should not be used as a substitute for exercise but rather as a complement to your regular workout regimen.

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Does Taking a Hot Bath Really Have the Same Health Benefits as Exercising? - Livestrong