Category Archives: Physiology

Sports science constantly reminds female athletes they are only guests in the sporting world – The Telegraph

First, though, youve got to get on the playing field. For women and girls that can be immensely challenging because from as early as primary school sport considers men and boys as the default. As a consequence, women and girls can feel their bodies and abilities dont quite measure up.

The consequences range from disappointing to dangerous. Sport is an incredible tool for personal development and well-being and no one should miss out because of their gender. Sport also tells us who is valued; who is welcome in the sports arena; who matters; and who matters a little less.

On the playing field, women learn the opposite of what society teaches them. Here, looks count for nothing (admittedly, this is still not true in the sport sponsorship arena, but well save that for another day). What matters is mental and physical strength, perseverance, teamwork, strategy, ability to deliver under pressure. These skills set us up for success in life and we cannot afford to miss out on half of the worlds potential.

Female athletes are constantly reminded that they are only guests in the sporting world, and the world of sports science is one of the worst offenders. Between 2011 and 2013, women accounted for just three per cent of participants in sport science studies. It is possible that much of what we know in the fields of physiology, nutrition, psychology, and strength and conditioning may not actually apply to women. Women are trained as though they are men but a woman will always make a second-rate man if she is having to be something she is not.

There are serious consequences to this approach. In my early years as an athlete, I thought it was quite normal not to have a regular period. In fact, I would use it as a marker that my training was going really well. It meant I was leaner, had more testosterone and was more like the ideal male athlete.

Female athletes across several sports have spoken out about similar thought patterns and a striving to be as lean as possible. Theoretically, it makes sense, especially for athletes involved in power events where a higher power-to-weight ratio means a better performance. But this does not take into account female physiology that requires a certain amount of fat cells to maintain a normal cycle, and that maintaining a menstrual cycle is important if you want improvement and sustained performance.

The consequences for female athletes who have spent long periods in energy-deficient states and without a menstrual cycle are scary, and the honesty with which athletes have spoken out is exactly the alarm bell that was needed.

To be clear, I am fairly certain sport scientists do not have an agenda against women and there is a good reason why they prefer male athletes for research: menstrual cycles can often make data difficult to interpret. I have sympathy for scientists who are under a lot of pressure to produce statistically significant results. But if you want to understand something more, you dive in. You do not avoid it.

The good news is that not only are sport science practitioners hungry for this data, but new technology is making it possible. In August, the English Institute of Sport announced the development of Hormonix an easy, rapid and accurate test for hormone levels that uses saliva. The more we understand female physiology, the more we can use it to our advantage. What if your coach was able to periodise your training alongside your period? What sort of power-and-strength gains can women achieve by making the most of variable hormone environments?

Thankfully, progress is happening. This year I was invited for a performance bra fitting ahead of the (now postponed) Tokyo 2020 Olympics and Paralympics. I had never previously considered breasts in terms of performance. Men dont have them, so they arent really on the agenda. I signed up immediately.

The fitting did not happen, because of lockdown, but Dr Emma Ross kindly took on my questions. She explained that if I were to run a marathon, the version of me wearing her performance sports bra versus me wearing a regular sports bra would finish a mile ahead. Yes, you read that correctly. That is roughly a four per cent improvement. Properly supported breasts impact stride length and centre of mass, all while allowing the lungs and rib cage to move and expand unrestricted. This is hugely exciting in a competitive landscape that idolises marginal gains. But I am equally excited for my best friend in university, who decided to quit her intramural football team because her breasts and back hurt too much when she ran.

These developments are desperately needed in a sporting world that continues to treat women as second-class citizens. Such as this summer when Canterbury launched their Ireland rugby jerseys using international male players for the mens jersey, and professional models for the womens; as though elite women rugby players simply dont exist. Canterbury did apologise, but it highlighted the fact that we celebrate men for performance and women for looking good.

There is so much to learn and so much to look forward to in womens sport. Im thankful for the sports scientists who are taking on uncharted territory. Im thankful for the women who are speaking out and challenging the status quo. I am thankful for men such as Dustin Fuller, who, from the very beginning, were prepared to use their influence to champion performance, regardless of gender. Most of all, I am excited for more women to learn about the awesome, untapped potential of their bodies. This is the new horizon of womens sport.

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Sports science constantly reminds female athletes they are only guests in the sporting world - The Telegraph

Daytime Sightings of Nocturnal Aardvarks Hint at Troubled Times in the Kalahari – SAPeople News

Aardvarks are notoriously elusive, nocturnal mammals. They generally hide in their underground burrows during the day and emerge at night to feed exclusively on ants and termites. Aardvarks are widespread throughout most habitats of Africa south of the Sahara, except deserts. But their actual numbers are not known because theyre so elusive.

Aardvarks top the bucket list of many wildlife enthusiasts, but few have been fortunate enough to see them until recently. Daytime sightings of aardvarks are becoming more common in the drier parts of southern Africa. But seeing them in the daytime does not bode well because it indicates they might not be finding enough food.

To understand how aardvarks cope with hot and dry conditions, we studied them in the Kalahari, one of the hottest and driest savannah regions in southern Africa in which aardvarks occur. Our study took place at Tswalu, a private reserve in South Africa that supports research through the Tswalu Foundation. We equipped wild, free-living aardvarks with biologgers (minicomputers) that remotely and continuously recorded their body temperature (an indicator of well-being in large mammals), and their activity. Each aardvark also received a radio-tracking device, allowing us to locate them regularly. Tracking the aardvarks provided clues on how they changed their behaviour in relation to environmental stressors in the different seasons and years of our three-year study.

Our study found that in drought periods, aardvarks struggled to find food. It was difficult for them to maintain their energy balance and stay warm during the cool night, so they shifted their active time to the day. Some died from starvation. Given the aardvarks importance to ecosystems, these findings are a concern.

Aardvarks usually emerge from their burrows at night (left), but during drought periods, they are increasingly seen during daytime (right). N. Weyer

No other mammal in Africa digs as many large burrows as the aardvark. Dozens of mammals, birds and reptiles use aardvark burrows as shelter from extreme heat and cold, protection from predators, or a place to raise their young. In many of South Africas conservation areas, temperatures have already risen by 2 over the past 50 years. Further warming by 4-6 by the end of the century has been projected.

With deserts and drylands expanding across much of Africa, climate change might threaten the aardvark itself as well as the many animals reliant on aardvark burrows as a cool shelter from rising temperatures.

During typical years, aardvarks were active at night and were able to regulate their body temperature between 35-37.

Aardvark active at night during non-drought times. adapted from Weyer et al., 2020, Frontiers in Physiology, https://doi.org/10.3389/fphys.2020.00637

However, this pattern changed during two severe summer droughts that occurred in the Kalahari during our study. During the droughts, aardvarks shifted their activity to the daytime and their body temperature plummeted below 30C.

Using remotely-sensed vegetation data recorded by NASA satellites and our own camera trap footage and logger data, we showed that these dramatic changes in body temperature and activity of aardvarks were related to the availability of grass, on which their ant and termite prey rely. When grass was scarce during droughts, the ant and termite prey became inaccessible to aardvarks, preventing them from meeting their daily energy requirements. As their body reserves declined, aardvarks were unable to sustain the energy costs of maintaining warm and stable body temperatures and shifted their activity to the warmer daytime.

Aardvark active in the daytime during drought. adapted from Weyer et al., 2020, Frontiers in Physiology, https://doi.org/10.3389/fphys.2020.00637

Shifting activity to the warmer daytime while food is scarce can save energy that would otherwise be spent on staying warm during cold nights. But, for our aardvarks, even these energy savings were insufficient during drought, when the ground was bare and the ant and termite prey inaccessible. As a result, seven of our twelve study aardvarks and many others died, presumably from starvation.

On the Red List of Species of the International Union for Conservation of Nature, aardvarks are currently categorised as a species of Least Concern. However, we consider aardvarks to be threatened in the drier parts of their distribution in Africa, such as the Kalahari, where climate change brings about droughts. Disappearance of aardvarks from these ecosystems could have devastating consequences for the many other animals that rely on the aardvarks burrows.

We hope that our findings will raise further awareness about the consequences of climate change and inform future wildlife conservation and management decisions. Such steps might include assessments of the actual population status of aardvarks across Africa, or mitigation measures to preserve species that depend on burrows for refuge in regions where aardvarks might go locally extinct. More extensive measures, like water-wise reserve management, increasing sizes and connectivity of nature reserves in semi-arid regions, and reducing emissions to mitigate climate change, are just as urgent.

Finally, any solution to the plight of climate change on free-living animals requires a better understanding of their capacities to cope with drought. Therefore, many more long-term comprehensive studies are needed on the physiology and behaviour of the vulnerable animals living in hot, arid regions of the world.

Robyn Hetem, Senior Lecturer, University of the Witwatersrand and Nora Marie Weyer, PhD Wildlife Conservation Physiology, University of the Witwatersrand

This article is republished from The Conversation under a Creative Commons license. Read the original article.

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Daytime Sightings of Nocturnal Aardvarks Hint at Troubled Times in the Kalahari - SAPeople News

Novel Antioxidant Seen as an Effective Strategy for Peripheral Artery Disease – BioSpace

OMAHA, Ne., Nov.20, 2020 /PRNewswire/ -- Researchers within the School of Health and Kinesiology at the University of Nebraska at Omaha (UNO) have found that a novel antioxidant can provide a number of health benefits for individuals with peripheral artery disease.

The antioxidant specifically targets mitochondria, considered the powerhouse of the cell. The study was led by Assistant Professor Song-Young Park, Ph.D., and published in the American Journal of Physiology-Heart and Circulatory Physiology.

Park recruited eleven men and women with PAD to participate in this research; six of which received 80 milligrams of the antioxidant while the remaining five participants were given a placebo. Measurements were done before and 40 minutes after each participant took the supplement or placebo to assess the roles of vascular mitochondria in endothelial function, arterial stiffness, exercise tolerance and skeletal muscle function. After a 14 day "wash out" period, the two groups switched, with the placebo group taking the supplement and vice versa and measurements were assessed again.

When a participant took the supplement, the researchers noted an increase in dilation of the arteries, popliteal flow-mediated dilation, antioxidant superoxide dismutase, maximal walking time and distance, and time to claudication or leg pain.

"The results of this study reveal for the first time that acute oral intake of a mitochondrial-targeted antioxidant is effective for improving vascular endothelial function and superoxide dismutase in patients with peripheral artery disease (PAD)," Park said. "This improvement is clinically important and such antioxidants may potentially be utilized as therapeutic supplement for patients with PAD".

The antioxidant, commercially available as MitoQ, contains the naturally occurring ubiquinol which is a coenzyme that gives the antixoxidant the ability to cross the cell membrane and accumulate within the mitrochondria.

Peripheral artery disease (PAD) is a common cardiovascular disease in which atherosclerotic plaque forms in the arteries of the leg which can cause decrease blood flow and reduced perfusion in the lower extremity. The disease affects nearly 200 million people worldwide, with over 20 percent of individuals over 80 years old being affected by this disease. Common symptoms often include foot ulcers and leg pain during walking. If severe, medical treatment up to and including leg amputation may be required.

This study was funded in part by the University of Nebraska at Omaha Graduate Research and Creative Activity (GRACA) grant awarded to Jiwon Song, University of Nebraska at Omaha University Committee on Research and Creative Activity (UCRCA) awarded to Song-Young Park and the NASA Nebraska Space Grant (#NNX15AI09H) awarded to Song-Young Park. Doses of MitoQ were donated to UNO by MitoQ Limited for use in this research study.

About the University of Nebraska at Omaha

Located in one of America's best cities to live, work and learn, the University of Nebraska at Omaha (UNO) is Nebraska's premier metropolitan university. With more than 15,000 students enrolled in 200-plus programs of study, UNO is recognized nationally for its online education, graduate education, military friendliness and community engagement efforts. Founded in 1908, UNO has served learners of all backgrounds for more than 100 years and is dedicated to another century of excellence both in the classroom and in the community.

View original content:http://www.prnewswire.com/news-releases/novel-antioxidant-seen-as-an-effective-strategy-for-peripheral-artery-disease-301176579.html

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Novel Antioxidant Seen as an Effective Strategy for Peripheral Artery Disease - BioSpace

November: Highly cited 2020 | News and features – University of Bristol

The Highly Cited Researchers 2020 list recognises 17 University of Bristol researchers reaching the highest sphere of influence in research.

The citation analysis, now in its seventh year, identifies those who have published a high number of papers that rank in the top one per cent most cited works in their field. This year,6,389 researchers are named in theHighly Cited List.

The 17 researchers on the list (whose primary affiliation is with Bristol) this year are:Professor Jerry Nolan, Bristol Medical SchoolDr Jane Ferrie, Bristol Medical SchoolProfessor David Gunnell, Bristol Medical SchoolProfessor Matthew Hickman, Bristol Medical SchoolDr Jo House, School of Geographical SciencesProfessor Marcus Munafo, School of Psychological ScienceProfessor Kate Tilling, Bristol Medical SchoolProfessor Jonathan Bamber, School of Geographical SciencesProfessor Jules Hancox, School of Physiology, Pharmacology and NeuroscienceProfessor Eamonn Kelly, School of Physiology, Pharmacology and NeuroscienceDr Stephen Lolait, Bristol Medical SchoolProfessor Neil Marrion, School of Physiology, Pharmacology and NeuroscienceProfessor Craig McArdle, Bristol Medical SchoolProfessor Philip Donoghue, School of Earth SciencesProfessor Julian Higgins, Bristol Medical SchoolProfessor Deborah Lawlor, Bristol Medical SchoolProfessor Jonathan Sterne, Bristol Medical School

Placement on the list, which is based on qualitative and quantitative data from the Web of Science, is a significant achievement for those named.

Web of Science is the worlds most trusted and largest publisher-neutral citation index, powering global discovery and citation analytics across the sciences, social sciences and the arts and humanities. With over 1.4 billion cited references going back to 1900 and millions of users per day from leading government and academic institutions and research-intensive corporations the Web of Science citation network serves as the foundation for the Journal Impact Factor, InCites and other powerful and trusted citation-impact measures. The Web of Science helps researchers, research institutions, publishers and funders discover and assess the citation impact of over a century of research publications found in the most prestigious books, conference proceedings and journals.

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November: Highly cited 2020 | News and features - University of Bristol

High-performance rugby programme launched – The Bay’s News First – SunLive

Expressions of interest for the 2021 High-Performance Rugby Pathway programme are now open.

The Bay of Plenty Rugby Union and Toi Ohomai Institute of Technology have partnered together to create the High-Performance Rugby Pathway - HPRP - delivered in three locations - Rotorua, Whakatane and Tauranga.

The HPRP is a one-year programme aimed at young athletes. The programme is designed to improve rugby athletes self-development in the areas of nutrition, exercise physiology, performance testing, sports psychology, and sport technology while formally studying for the Level Certificate in Exercise, and Certificate in Freestyle Group Exercise qualifications from Toi Ohomai.

The HPRP programme is being delivered in three locations to enable athletes to remain close to home, and support rugby in their communities, says a Bay of Plenty Rugby Union spokesperson.

The HPRP is a one-year programme aimed at recent school leavers and is designed to improve rugby athletes self-development in the areas of nutrition, exercise physiology, performance testing, sports psychology, and sport technology while formally studying for the Level Certificate in Exercise, and Certificate in Freestyle Group Exercise qualifications from Toi Ohomai.

The Bay of Plenty Rugby Union is committed to growing community rugby, so selection preference will be given to athletes who share this commitment.

On completion of this programme, graduates will be able to:

Choreograph, deliver and adapt safe and effective group exercise classes for one or more different class types and varying exercise abilities. Encourage group exercise participants to develop skills and knowledge to improve own health and wellbeing. Integrate culturally appropriate values, processes and protocols to respond to participant exercise needs. Enhance movement patterns in group exercise classes by utilising knowledge of anatomy and physiology. Use business skills and create an awareness of exercise products and services to develop and maintain a client base. Deliver safe and effective exercise programmes, including prescreening, within own scope of practice and industry code of ethics. Apply knowledge of anatomy and physiology to adapt and deliver safe and effective exercise programmes to individuals. Adapt programmes for apparently healthy people and common at risk groups using exercise science and testing. Apply motivational and communication techniques to enhance individual participant commitment to a personalised exercise programme. Apply a health and wellness framework and evidence-based nutrition principles to support a personalised exercise programme and recommend referral pathways to allied health professionals. Use marketing and business tools and techniques to support business practices as an exercise professional.

Interested people can complete the online form to register their interest in the 2021 High-Performance Rugby Pathway (HPRP) programme.

Applicants will be required to attend an interview and an information sharing session where they will be informed of programme structure and expectations as well as progression options.

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High-performance rugby programme launched - The Bay's News First - SunLive

Field Trip Enters Partnership to Measure Psychedelic Therapies on Physiology & Mental Health – Stockhouse

Field Trip Health Ltd. (CSE: FTRP, Forum) announced on Thursday that it is partnering with WHOOP, the human performance company, provides a membership for 24/7 coaching to improve health, where Field Trip will use WHOOP Strap 3.0 to measure the biometric effects of Field Trip’s psychedelic therapies.

To read this news in full, click here.

A developer of psychedelic therapies, FTRP recently made news when it entered into a lease and stated its plan to open a Field Trip Health Centre in Amsterdam, Netherlands, expected to open in March 2021.

FULL DISCLOSURE: Field Trip Health Ltd. is a client of Stockhouse Publishing.

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Field Trip Enters Partnership to Measure Psychedelic Therapies on Physiology & Mental Health - Stockhouse

Auburn University researchers first to discover natural, metal nanoparticles in animal body; study has implications in restoring or enhancing sense of…

"Scientists have long known animal tissue has minerals in ionic and atom-bound states, but no one knew metal nanoparticles were naturally in the animal body," said Vitaly Vodyanoy, professor of physiology in the College of Veterinary Medicine. "This is the first time a third state of metal has been observed in the body."

The study, "Endogenous zinc nanoparticles in the rat olfactory epithelium are functionally significant," was published in the Oct. 28 edition of the journal, Nature Scientific Reports.

The importance of the finding is that metal nanoparticles donate or accept many more electrons toward enzymatic reactions than available from single, metal ions. Nanoparticles are structures composed of many atoms, while ions are electrically charged atoms created by the loss or gain of one or a few electrons.

"Some scientists suggest electrons trigger the sense of smell," Vodyanoy said. "Therefore, metal nanoparticles, which can operate with many electrons, have an advantage over metal ions in smell enzymatic reactions."

The research, using laboratory rats as the animal model, found zinc nanoparticles in the nose olfactory neurons' cilia, the part of a neuron that contains olfactory receptors. Until this study, the only known zinc in the body was in an ionic or bound state.

"This is also the first study to show zinc is in the cilia," he said. "It's not a single atom, but nanoparticles with 50 to a few hundred atoms of metal. We proved zinc naturally exists in the animal body, which we believe would include humans."

When dissected, the cilia of the neurons became liquid bubbles, which Auburn researchers collected and sent to the National Institute of Standards and Technologythe study's funding agencyto perform electron diffraction to look for nanoparticles.

"We had already determined it was zinc using our physiological experiments, but we wanted NIST's confirmation with their electron microscope, and for NIST to perform electron diffraction to pinpoint if the zinc was clustered as nanoparticles," Vodyanoy said. "It was natural zinc nanoparticles."

Zinc, to this point, was thought only to exist in the body as ions or organically bound atoms derived from foods or vitamin supplements. Without zinc in the body, an animal or person will lose the sense of smell.

Three-fold increase in smell

The finding of zinc nanoparticles builds upon Vodyanoy's prior research, dating to 2005, and should open the door for future research globally into restoring or enhancing the sense of smell, as well other areas involving enzymatic reactions.

"Our current study found that natural zinc from the olfactory neurons' cilia produces the same increase as nanoparticle-engineered zinc," he said. "We previously found if you add zinc, either natural or engineered, with a puff of air to anything with an odor, we see a three-times increase in an animal's olfactory response," said Vodyanoy, who demonstrated this increase in a 2009 study.

The three-fold increase, he says, is the result of the zinc-and-odorant mixture producing additional pairs of proteins, or dimers, in the cilia.

"We had hypothesized that when zinc interacts with olfactory receptors, it produces a dimer, which is necessary for the increased sense of smell," he said. "Our research showed it to be accurate."

He says the advantages of natural zinc nanoparticles versus artificially engineered zinc nanoparticles are more stability and longer shelf life. When both are protected against oxidation with a thin layer of organic material, the natural zinc will last several years, while the artificial will last up to a year, based on his previous research.

Vodyanoy says his lab's future studies will seek to determine how animals have zinc metal nanoparticles in the nose's neuron cilia.

"We hypothesize a microorganism in the gut converts zinc ions from foods to zinc metal nanoparticles in the nose," he said. "We hope to find out."

Potential benefits

Vodyanoy says the discovery of zinc nanoparticles will add to the knowledge base of how zinc and olfactory receptors work and should advance the understanding of the sense of smell. Restoring or enhancing the sense of smell is one possible future benefit.

"Diseases like Parkinson's, Alzheimer's and now COVID-19 often cause a person to lose the sense of smell," he said. "I believe we could research ways to add a small and safe amount of zinc to food or drink, possibly as an aerosol, to allow patients to smell these foods again.

"Aromas are important in perception of our food and beverages. Food industries use a variety of chemicals, essential oils and botanicals to accentuate the smell of food. Zinc nanoparticles can be used for the enhancement of aromas in food and to make it more attractive and healthier."

He also says zinc has been shown to play a role in the memory process, and his study could provide valuable information to those studying Alzheimer's.

Agencies using detection dogs could benefit from future research as well. In preliminary studies, Vodyanoy says zinc added with a puff of air onto a surface will give the dog the three-fold increase in smelling for contraband like drugs or explosives.

The perfume industry, he adds, could look at zinc as a method to increase the stability and essence of perfume.

Research team and process

"A well-educated and skillful scientific team is critical for successful research," Vodyanoy said. "I am fortunate to have excellent scientists around me."

The team members included:

"Melissa Singletary would make a microsurgical extraction of tissues containing olfactory cilia, and then she, Samantha Hagerty and Oleg Pustovyy measured electrical signals excited in cilia by odorants and zinc nanoparticles," Vodyanoy said.

"Ludmila Globa prepared cilia samples on optical slides for high-resolution, fluorescent microscopy carried out by Oleg Pustovyy. June Lau then confirmed the presence of natural zinc metal nanoparticles in cilia by using electron microscopy and diffraction."

Vodyanoy analyzed the experimental data and wrote the manuscript for the team.

SOURCE Auburn University

http://www.auburn.edu

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Auburn University researchers first to discover natural, metal nanoparticles in animal body; study has implications in restoring or enhancing sense of...

Novel Antioxidant Seen as an Effective Strategy for Peripheral Artery Disease – PRNewswire

OMAHA, Ne., Nov.20, 2020 /PRNewswire/ -- Researchers within the School of Health and Kinesiology at the University of Nebraska at Omaha (UNO) have found that a novel antioxidant can provide a number of health benefits for individuals with peripheral artery disease.

The antioxidant specifically targets mitochondria, considered the powerhouse of the cell. The study was led by Assistant Professor Song-Young Park, Ph.D., and published in the American Journal of Physiology-Heart and Circulatory Physiology.

Park recruited eleven men and women with PAD to participate in this research; six of which received 80 milligrams of the antioxidant while the remaining five participants were given a placebo. Measurements were done before and 40 minutes after each participant took the supplement or placebo to assess the roles of vascular mitochondria in endothelial function, arterial stiffness, exercise tolerance and skeletal muscle function. After a 14 day "wash out" period, the two groups switched, with the placebo group taking the supplement and vice versa and measurements were assessed again.

When a participant took the supplement, the researchers noted an increase in dilation of the arteries, popliteal flow-mediated dilation, antioxidant superoxide dismutase, maximal walking time and distance, and time to claudication or leg pain.

"The results of this study reveal for the first time that acute oral intake of a mitochondrial-targeted antioxidant is effective for improving vascular endothelial function and superoxide dismutase in patients with peripheral artery disease (PAD)," Park said. "This improvement is clinically important and such antioxidants may potentially be utilized as therapeutic supplement for patients with PAD".

The antioxidant, commercially available as MitoQ, contains the naturally occurring ubiquinol which is a coenzyme that gives the antixoxidant the ability to cross the cell membrane and accumulate within the mitrochondria.

Peripheral artery disease (PAD) is a common cardiovascular disease in which atherosclerotic plaque forms in the arteries of the leg which can cause decrease blood flow and reduced perfusion in the lower extremity. The disease affects nearly 200 million people worldwide, with over 20 percent of individuals over 80 years old being affected by this disease. Common symptoms often include foot ulcers and leg pain during walking. If severe, medical treatment up to and including leg amputation may be required.

This study was funded in part by the University of Nebraska at Omaha Graduate Research and Creative Activity (GRACA) grant awarded to Jiwon Song, University of Nebraska at Omaha University Committee on Research and Creative Activity (UCRCA) awarded to Song-Young Park and the NASA Nebraska Space Grant (#NNX15AI09H) awarded to Song-Young Park. Doses of MitoQ were donated to UNO by MitoQ Limited for use in this research study.

About the University of Nebraska at Omaha

Located in one of America's best cities to live, work and learn, the University of Nebraska at Omaha (UNO) is Nebraska's premier metropolitan university. With more than 15,000 students enrolled in 200-plus programs of study, UNO is recognized nationally for its online education, graduate education, military friendliness and community engagement efforts. Founded in 1908, UNO has served learners of all backgrounds for more than 100 years and is dedicated to another century of excellence both in the classroom and in the community.

SOURCE University of Nebraska at Omaha

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Novel Antioxidant Seen as an Effective Strategy for Peripheral Artery Disease - PRNewswire

The secrets of the world’s fastest marathon runners – Runner’s World (UK)

Professor Andrew Jones has played an integral part in some of the greatest marathon stories in history. The University of Exeter professor of applied physiology helped to guide Paula Radcliffe to her stunning, long-standing world record in London, in 2003; and he also worked with Eliud Kipchoge on the Breaking 2 project, the culmination of which was the first sub-two-hour marathon in history. In a long and distinguished career exploring the science behind speed and endurance, Jones has written more than 350 original research and review articles, and worked as a consultant to UK Athletics and the English Institute of Sport. This year, he has been working towards a defining marathon performance thats a little easier for us all to relate to his own attempt to break the hallowed three-hour mark for the first time, at the age of 50 and translating his unparalleled wealth of experience into his training. We caught up with him to hear about the scientific knowledge he has employed to help the worlds best get even better, what he has learned about them that sets them apart, and how we can apply it all to our own running.

AJ It started with me as a reasonably successful junior runner [Jones is being rather modest here as this included numerous Welsh Schools/AAA titles, coming third in the British Schools 3000m, running a 3:58 1500m and an 8:38 3000m in 1986, which ranked him as one of the fastest Youths in the UK; in 1987, he ran 30:13 for 10K and 66:55 for the half marathon, which were UK Age 17 best performances].. Like a lot of people, I was somewhat self-coached, and I just became fascinated by the science that underpinned running performance. That led me to study sports science at university, where my various injuries and illnesses came along and my own running fell a little by the wayside, but I continued to be fascinated by physiology, by what it is that makes some people run faster than others and what we can do to make people run faster.

I did a PhD in exercise physiology and I became fascinated with the research side, but having a link with sport was always important to me. Along with doing the more sophisticated lab-based work, which was all about trying to discover the mechanistic basis behind athletic performance, I was always keen to apply that knowledge in the real world to help athletes run faster. So I kind of lived a bit vicariously through some of the athletes I supported over those years.

You know that debate that you sometimes have in the pub after a training sessionwould you rather win an Olympic Gold medal or set the world record? I was always in the latter camp because I thought you can win an Olympic Gold by beating the people who are there on that particular day, which is obviously no mean feat, but to beat the fastest athlete of all time at a given distance I thought that was something really special. Of course at some point it might be beaten, but at least for that period of time you can say that you are the fastest athlete who ever lived over that distance, and that really appeals. As scientists, we are fascinated by how fast people can run.

I think when it comes to distances like the 100m or the mile, those distances are run so frequently that we are probably approaching the limits. The marathon is different because the athletes race the distance so infrequently, and the courses that marathons are run on arent necessarily ideal for the fastest times, and when the top athletes do get together its generally at a major championships, so the goal is to win rather that to run as quickly as possible. So when it came to the Breaking 2 project, it was about creating a real opportunity to discover what was humanly possible. Its those ultimate limits in terms of how fast can people run and what prevents them from going faster that continue to fascinate me.

First of all, they are physically phenomenal; theres no getting away from that. You simply have to have the underpinning physiology. However, there are probably other people who are similarly physiologically talented, and so you also have to have the right psychology. I dont necessarily mean just in the race itself clearly you have to have the confidence, the motivation, the ability to hurt yourself in the race but its also about having the patience, the longevity. This is especially true when it comes to the marathon because you might not hit your very best until youre in your early to mid 30s. You might have shown your early promise as a teenager, like both Paula and Eliud, so that means youve got to train for about 15 years. We all know how hard maintaining training can be and when you scale it up to the top athletes it means running as much as 10 or 12 times per week every week for 15 years consecutively.

You have to get everything right around training and recovering.

It also means that you have to get everything else right around training and recovering and you really have to sacrifice a lot. Its that monk- or nun-like existence that you have to buy into if youre going to achieve what youre ultimately capable of in the long term, whoever you are.

These are certainly lessons that you can learn from the greats, but obviously youve got to dial it back. And especially when you get a bit older. One thing I have learned as I have continued to try to run over the decades is that youve just got to be kinder to yourself. As you get a bit older, you become more susceptible to injury, you simply cant take the load and the speed in the same way that you used to. Your bones, tendons and muscles become more prone to injury so you have got to build in a lot more recovery.

Thats certainly a lesson to be taken from the Kenyan approach. Ive had the opportunity to spend some time with [Kipchoges coach] Patrick Sang in Eliuds training camp in Kenya and one thing that comes through very strongly is that while they train pretty hard most of the time and certainly very consistently, when they are not training they really do relax. They enjoy each others company and they really know how to chill out.

Another thing about the top Kenyan runners is that they dont stick rigidly to a training formula. As a scientist, I really like to plan my training and to stick to it meticulously if I possibly can, but, actually, you have to be flexible. Its that old adage that youve got to listen to your body, but is absolutely true.

I dont think the Kenyan athletes I spent time with really know exactly what theyre going to do from one day to the next because it will be modified by Patrick according to how they responded to the last session and how they feel. So being a little bit looser in the way we structure our training is probably one of the lessons.

Its better to train at 90 per cent effort than to get injured or burn out.

And really it was the same with Paula she would quite often train as hard as she could for as many days in a row as she could, but then shed then wake up one morning and feel that she was barely capable of running at all. When that happened, rather than run a half-hearted session she would take a complete rest day. She wasnt afraid to do that. Its about having courage and confidence in your training and that doesnt always mean training harder and harder, and doing more and more all the time, it sometimes means backing off. You have to be able to maintain it. Its better to train at 90 per cent effort for a long period than to overdo it and get injured or burn out psychologically. And I think thats perhaps a surprising lesson: that it isnt necessarily the case that these great athletes are always training so much harder than the rest of us, they just train more sensibly.

There isnt any real consensus on this, so you do get people espousing different views and methods. When it come to the elites, they certainly all do a bit of it, but the important thing is that strength training doesnt override your running training. It needs to supplement and complement the running training you do.

It also depends a little on the type of runner you are and the type of event youre training for. You clearly need to have sufficient strength when it comes to shorter distances, but its less crucial when it comes to the marathon. The type of training that can be really beneficial to marathon runners is plyometric-type work, which can augment running economy adaptations. I dont think you need to be lifting particularly heavy weights.

The key thing you have to remember is that every training session you do whether it be running or weight training or whatever takes something out of you, so its all about the balance. If the strength training doesnt drain your energy resources and prevent you from getting the maximum from your running training sessions, then thats fine, go ahead. But if youre so tired or sore that you cant put in a good long run or interval session, that might well mean that youre doing too much.

Also consider if your strength training takes a lot of time say an hour, three times a week and thats cutting into the time that you would otherwise spend running. So doing some is probably a good thing, but you have to make sure that you dont do too much as it will never be a substitute for the running itself.

Paula used to do a couple of weight training sessions per week, which was enough, but not enough to compromise the endurance work that she was doing. As for Eliud, he and the other Kenyan athletes I spent time with dont do much strength work when they are in their specific marathon training block. They do some conditioning, so they recover after their most recent marathon, then they start to do some easy running and some conditioning and body weight exercises. They do maintain core-strength exercises, which is something that has changed in their approach over the last couple of years, but theres no weight-training facility in camp, so when they are doing their final 10-12 weeks of marathon training they really dont do a lot of weights.

What the Kenyan athletes certainly do is run across a lot of undulating terrain. From speaking to some of the physios who work with the leading east African runners, its clear when you look at their feet and their lower legs, they are extremely muscular. Theyve got muscles on their feet that you didnt know existed. Thats partly because they are barefoot a lot of the time, but its also because the terrain they run on is really rugged its up and down and its side-to-side and its quite often in heavy mud as well. So, in a sense, they are doing a fair bit of resistance training while they run.

Im definitely in the high-carb camp. I think if youre a very slow marathon runner or an ultra endurance athlete then because the intensity is so much lower, training yourself to use fat as fuel may be the way forward. However, when it comes to trying to run a marathon quickly or any shorter distance, then the most efficient fuel to use is carbohydrate that will keep your oxygen uptake low, so it will maintain your running economy.

My experience has shown that its really important that not only do you go into a marathon with lots of carbohydrate already within your muscles in the form of glycogen, but also that you make every effort to take as much carbohydrate into your system as you can while running. You should just about have enough carbohydrate to get you through a marathon if you go into it glycogen-loaded and you take in a further 60-70g per hour at the elite level, or a bit less for us non-elites. If you do so, youll have the right fuel to run at the intensity you want to sustain.

Its also important to take the carbohydrate in at an early stage. I think the mistake many people make is that because they dont feel thirsty, or because they feel full of energy in that first hour they dont pay sufficient attention to their nutrition then, but doing so will pay huge dividends later in the race.

Paula didnt want to stop. She would rather fall off the treadmill than quit. Eliud is a calmer, more reserved character, but hes also mentally extremely strong. He and the other Kenyan athletes Ive spent time with certainly do know how to push themselves, but I dont think that is expressed in their running form to such an the same extent.

When I was consultant physiologist to British Athletics, I accompanied some of our runners up to altitude training camps in Kenya on a few occasions and its really interesting when you watch groups of Kenyans and groups of Brits do their track sessions. Im certain that they are working equally as hard and yet when you watch the Brits finish their reps their form falls to pieces you can tell that they are fatigued just by looking at their stride and their upper bodies, but the running economy and the running form of the Kenyans doesnt seem to deteriorate to the same extent. Im sure that they are hurting just as much and working just as hard, but it doesnt seem to impact their running form to such an extent.

You can measure the various parameters and variables VO2 max, lactate threshold, running economy that we think are key to marathon success at the start line, but you have to remember that those variables all change as the marathon progresses. And thats something that we cant measure in the lab. So my VO2 max and my running economy will get worse as I run, and if you measured me after two hours of my three-hour marathon run, the numbers you would get then would be very different to what they were on the start line. I suspect in people like Eliud the numbers dont deteriorate anything like as much he has incredible fatigue resistance. I think thats the other dimension that makes runners like Kipchoge so special. Interestingly, when we measured his numbers in the testing and selection for Breaking 2, they were obviously right up there with the best, but they werent necessarily the best of the lot.

A key thing I take from my experience of working with Kipchoge, and on the Breaking 2 project in particular, is his self-belief. Of all the athletes that we tested and we selected, Eliud was probably the only one who genuinely believed it was possible. He had unwavering, unshakeable confidence in his own ability and coaching, training and preparation. He dares to think beyond the current limits.

Im on slightly shaky ground here as Im a physiologist not a psychologist. I do believe that you need to dare to dream and I love Eliuds slogan that no human is limited, but I also believe that we do have our limits and my job as a physiologist is to determine exactly where those limits are. Theres no point in you or I dreaming that we can run a two-hour marathon because we simply havent got the ability. You have to make sure that your dreams are realistic as a well as challenging, but I agree that if we put our minds to it, dare to dream, and then prepare accordingly then we can all achieve a little bit more than we might expect.

We saw Eliud run 1:59 and he did not even look particularly stretched. When we gave him an honorary doctorate at the University of Exeter last year we asked him how hard it was, and could he have gone any faster. He said it wasnt that hard and he could have gone a lot faster!

People may say it was all about the manufactured course and everything else and that itll never happen in London or Berlin but I wouldnt be surprised if it did, especially if he had a bit of competition and people to draft behind for a little bit longer. My mind certainly wouldnt be blown if we saw sub-two on a regular marathon course. It could be by Eliud, but theres great strength of depth in the athletes coming through now some of the athletes coming out Uganda at the moment are incredible. So I think that well see sub-two happen again in other competitions.

Original post:
The secrets of the world's fastest marathon runners - Runner's World (UK)

Scientists reveal new evidence of electrical pathway in the heart – News-Medical.Net

Reviewed by Emily Henderson, B.Sc.Nov 17 2020

These days having both a land line and a mobile phone seems like overkill. But Virginia Tech researchers have shown that the heart relies on at least two key communication channels to keep abnormal heart rhythms in check.

In a study published in the American Journal of Physiology Heart and Circulatory Physiology, Fralin Biomedical Research Institute at VTC scientists reveal further evidence of the "nuanced interplay" between two prominent cell-to-cell communication pathways that could influence how patients fare during a heart attack.

The research team, led by associate professor Steven Poelzing, discovered it could improve irregular heart rhythms even when the heart's blood supply was completely shut off just by altering concentrations of common electrolytes in the bloodstream.

This discovery could have important implications for the prevention and treatment of heart disease, which is the leading cause of death in the United States, according to the Centers for Disease Control and Prevention.

"Millions of Americans take anti-arrhythmic medications or suffer from heart disease. By shedding light on these basic physiological principles, our research could one day help us develop more effective medications and personalized saline solutions to help prevent dangerous arrhythmias," said Poelzing, who is also an associate professor in the Department of Biomedical Engineering and Mechanics in Virginia Tech's College of Engineering.

"Our goal is to one day help cardiologists identify if a patient could be at higher or lower risk of developing a dangerous arrhythmia based on their blood chemistry."

Like a phone line, gap junctions are proteins that bridge two adjacent cells. These channels let small molecules, including ions, flow straight from one cell to the next, triggering the ripple of cellular contractions that allow our hearts to beat.

For roughly a century, scientists believed that these protein channels explained how the heart's electrical impulses passed from cell to cell. But within the past 15 years, mounting evidence has shown that gap junctions aren't the only mechanism underlying electrical conduction in the heart.

When researchers genetically knocked out most of the heart's gap junctions in mice, they were surprised to find that the test subjects were just as likely to live an ordinary lifespan as their healthy counterparts.

How can hearts to beat if most of the physical ports between their cells are missing? To answer this question, a theory ephaptic coupling has re-emerged.

Ephaptic coupling occurs within microscopic spaces wedged between two cell membranes. These pockets, called the perinexus, were first described by Fralin Biomedical Research Institute scientists in 2013 and span just one to two ten-thousandths of a millimeter. For the signaling to work, two cells need to be close enough to sense the electric field generated by their neighboring cell.

You can think of ephaptic coupling between cells in the context of magnets: When you have two magnets close together they are strongly attracted to each other due to the strength of the magnetic field; similarly, the closer two cells are to one another, the stronger the effect of the electric field will be on each other. But when you pull two magnets apart, you can feel the point where attraction weakens. The same thing happens with electric fields. When the space between cells increases, ephaptic coupling weakens."

Gregory Hoeker, Study First Author and Research Assistant Professor, Poelzing's lab, Fralin Biomedical Research Institute

When blood stops flowing to the heart muscle, its tissues can swell up. This extra fluid between cells pushes the heart cells apart, expanding the width of the perinexus, and preventing ephaptic coupling.

In this new study, Poelzing's team discovered how the spacing between heart muscle cells changes during a heart attack depends on the specific recipe of electrolytes calcium, sodium, and potassium present in the bloodstream.

At the organ level, this prevents the heart beats from slowing down and becoming disorganized, which helps normalize the heart rhythm during a heart attack.

"We're learning that a patient's blood salt chemistry before and during a cardiac event is important and could impact their prognosis," Hoeker said.

"The data we have collected so far suggest that these two forms of electrical communication gap junction coupling and ephaptic coupling interact in complex ways. Sometimes they work together, sometimes they oppose one another. We believe this balance helps support safe conduction in the heart."

But there doesn't seem to be a one-size-fits-all cardioprotective cocktail of electrolytes. One patient may need more calcium and sodium, while another needs less.

Small fluctuations in either direction can have a big impact on heart conduction depending on the patient's baseline blood chemistry.

That's why Poelzing and his team are researching how different saline solutions, ranging from your common intravenous fluid drip bag to the wash that surgeons use during open heart surgeries, impact cardiac function and can contribute to arrhythmias.

The researchers say future experiments will examine how gap junctions and ephaptic coupling interact.

"Our next research step is to take a multilayered approach, using peptide treatments to target gap junctions and different electrolyte fluids to modulate ephaptic coupling, so we can see how these systems work together during an event such as cardiac arrest," Hoeker said.

Source:

Journal reference:

Hoeker, G. S., et al. (2020) Attenuating loss of cardiac conduction during no-flow ischemia through changes in perfusate sodium and calcium. American Journal of Physiology. doi.org/10.1152/ajpheart.00112.2020.

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Scientists reveal new evidence of electrical pathway in the heart - News-Medical.Net