Category Archives: Physiology

News of the Weird | National | lagrandeobserver.com – La Grande Observer

Youre going to need a bigger boat a much bigger boat

BRISTOL, England Paleontologists with the University of Bristol, England, have unveiled the true size of the prehistoric mega-shark megalodon.

Today, the most fearsome living shark is the Great White. Adults can exceed 20 feet in length and bite with a force of two tons.

The University of Bristol in a press release Sept. 3 announced new research estimating the Great Whites fossil relative was more than twice that long and could bite with a force of 10 tons.

The massive predator and star of a share of B movies lived from 23 million to around three million years ago. The fossils of megalodon are mostly huge triangular cutting teeth bigger than a human hand.

Jack Cooper, who completed his masters courses in palaeobiology at the University of Bristols School of Earth Sciences, and colleagues made close comparisons to a diversity of living relatives with ecological and physiological similarities to megalodon, according to the press release, and used a number of mathematical methods to pin down the size and proportions of this monster.

Shark expert Dr. Catalina Pimiento from Swansea University and professor Mike Benton, a palaeontologist at Bristol, supervised the project. Professor Humberto Ferrn of Bristol also collaborated.

The journal Scientific Reports published the research.

I have always been mad about sharks, Cooper said in the press release. As an undergraduate, I have worked and dived with Great whites in South Africa protected by a steel cage of course. Its that sense of danger, but also that sharks are such beautiful and well-adapted animals, that makes them so attractive to study.

Megalodon, he continued, was actually the very animal that inspired me to pursue paleontology in the first place at just 6 years old.

Previously the fossil shark, known formally as Otodus megalodon, was compared with the Great White.

Cooper and his colleagues, for the first time, expanded this analysis to include five modern sharks. Pimiento said in the press release that megalodon is not a direct ancestor of the Great White but is equally related to makos, the salmon shark and porbeagle shark.

We pooled detailed measurements of all five to make predictions about megalodon, he said.

Benton explained the team first had to test whether these five modern sharks changed proportions as they grew to adulthood.

If, for example, they had been like humans, where babies have big heads and short legs, he said according to the press release, we would have had some difficulties in projecting the adult proportions for such a huge extinct shark.

He said they were surprised and relieved to discover the babies of all these modern predatory sharks start out as little adults and dont change in proportion as they get larger.

Cooper added this meant they could take the growth curves of the five modern forms and project the overall shape as they get larger and larger.

Right up to a body more than 52 feet long.

The results suggest at that size, Otodus megalodon likely had a head about 15 feet long, a dorsal fin approximately 5.3 feet tall and a tail almost 13 feet tall.

The reconstruction of the size of megalodon body parts represents a fundamental step towards a better understanding of the physiology of this giant, according to the press release, and the intrinsic factors that may have made it prone to extinction.

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News of the Weird | National | lagrandeobserver.com - La Grande Observer

Want to study better? Just two minutes of exercise beforehand could help – KTVZ

If youre feeling a bit sluggish today, just two minutes of exercise could give your brain a boost, a new study shows.

Researchers from Jnkping University in Sweden analyzed a range of 13 studies into the effects of exercise on people aged 18-35 conducted by scientists between 2009 and 2019.

Writing in the journal Translational Sports Medicine last month, they concluded that between two minutes and one hour of aerobic exercise such as running, walking or cycling improves learning and memory functions in young adults.

Exercise at moderate to high intensity, even for just 120 seconds, they added, improved learning memory, planning and problem solving, concentration (and) verbal fluency, with the positive effect lasting up to two hours.

The researchers said there was a connection between exercise and learning ability, which suggests that exercising before you work or study could be beneficial though they said more research was needed to identify optimal exercise strategies.

This systematic review shows that aerobic, physical exercise before encoding improves learning and memory functions in young adults, the authors said.

Encoding, the researchers explained, is the first stage in the brains process of storing information to memory, and is the processing of the information phase.

This is not the first study to show the benefits of exercise for wellbeing.

A study of people with an average age of 66 published in the American Academy of Neurology journal in May found that regular exercise can increase thinking and verbal skills of older adults, too.

This is because increasing the heart rate through exercise pumps more oxygen-rich blood to the brain, stimulating the release of hormones that boost the production of new brain cells.

Even if you start an exercise program later in life, the benefit to your brain may be immense, study author Marc Poulin, an exercise physiology and nutrition professor at the University of Calgary in Alberta, Canada, told CNN at the time.

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Want to study better? Just two minutes of exercise beforehand could help - KTVZ

Research Antibodies Market: Report Analysis Global Market Revenue and Share by Manufacturers Boosting the Healthcare Industry Worldwide – Owned

The global research antibodies market is anticipated to rise at a notable pace over the forecast period. Antibodies display exceptional physiological properties that make them sought-after for cell research.

Antibodies display other properties too. As they have the ability to attach to specific molecules, this enables specific molecules to be isolated for research. Hence, this makes for a key factor for continual research to examine the physiology and anatomy of antibodies.

The report serves to identify prevailing growth trends based on which projections made. The report constitutes most relevant data pertaining to comprehend the growth dynamics of research antibodies market. Geographical distribution of the research antibodies market and an analysis of the competitive structure are highlights of the report.

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Global Research Antibodies Witness Most Promising Rise in Demand

Currently, pharmaceutical and biopharmaceutical companies are undertaking extensive R&D activities to introduce novel products. These pursuits involve widespread use of antibodies because of their exceptional physiological properties. Therefore, research on antibodies receives a boost for their use in secondary cell research.

At present, stem cell research is finding keen interest of researchers and geneticists. Several studies support the efficacy of stem cell for blood cancers, blood and bone marrow diseases, immune disorders. Lately, stem cells from the umbilical cord and stem cells from the blood stream have been used to treat rare blood related diseases. Due to the dependency an antibodies for stem cell research, researchers are involved to isolate different antibodies molecules. This is aiding growth of research antibodies market.

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The study offers an in-depth assessment of various customers journeys pertinent to the market and its segments. It offers various customer impressions about the products and service use. The analysis takes a closer look at their pain points and fears across various customer touch points. The consultation and business intelligence solutions will help interested stakeholders, including CXOs, define customer experience maps tailored to their needs. This will help them aim at boosting customer engagement with their brands.

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Prominent players in the global research antibodies market include Abcam plc, Agilent Technologies, and Thermo Fisher Scientific Inc.

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Research Antibodies Market: Report Analysis Global Market Revenue and Share by Manufacturers Boosting the Healthcare Industry Worldwide - Owned

The benefits of using organic beauty – Marie Claire UK

If you're serious about shopping sustainably and ethically, look for the Soil Association COSMOS Organic logo

Did you know there is no legislation in place to monitor the use of the word organic within the beauty industry? Thats why opting for Organic Certification is so important. Heres how.

The insatiable demand for beauty products comes with a major environmental impact, with as much as 70% of plastic waste generated by the industry not being recycled and ending up in landfill.

The way forward is clearly to overhaul the way we package and produce, namely by implementing alternatives to plastic packaging, by establishing responsible recycling schemes, and by making sustainably sourced and organic ingredients the norm. There is firm evidence that consumers are appreciating this shift towards more eco-responsible practises much more right now too.

The good news is that even small changes would make a major positive impact on the environment.For Organic Beauty and Wellbeing Week the Soil Association is urging consumers to make One Small Swap by switching non-organic beauty and wellbeing products to certified organic because these products have followed strict sustainability requirements and will make a world of difference.

Choose organic sanitary care. Natracare are fully committed to making eco-friendly products with zero-waste manufacturing using green energy. The goal for them is to reduce plastic footprint with biodegradable menstrual products by using natural materialsand 100% certified organic cottonso unlike conventional brands, they wont be polluting the earth for the next 500 years.

Another brand doing sustainability thoroughly is Hoama. The founder Enis Anteplioglu believes that preservatives are avoidable and most of the time harmful to ecosystems so has innovated by using bio-phytonic science violet coloured glass bottle technology that helps protect the ingredients.Antelplioglu also supports sustainability through use of ingredients so opts for organic, without any herbicides, pesticides, fungicides, petroleum waxes, and a complete ban on unsustainable ingredients like sandalwood and any plants about to go extinct.

Theres still work to be done, but the industry support for sustainability, with companies like brands Natracare and Hoama, is encouraging, and we hope that more will follow suit and fast.

Beauty is adapting. As weturn to nature for its wellbeing benefits and climate change continues to take devastating turns, there has been a shift towards natural and organic ingredientswhen it comes to skincare and cosmetics and that echoes the clean eating movement in how its driving trends.

Two brands that have helped consumers make their first step into greener living very successfully are Indie Lee and Garniers Organic Range.

Starting her journey with the organic food movement, founder Indie Lee began thinking about the bigger picture and started her mission to create a beauty line that was safe and effective, while educating and empowering others about what they were putting on their skin. Knowing the power that real food has on the healing effect internally, sourcing ingredients from mother nature for skincare became increasingly more important. Additionally, using green chemistry and that science to amplify the potential of their ingredients means you no longer have to sacrifice efficiency when using ingredients that are from nature. For example, they are now able to find peptides and ceramides that are plant-derived. As this green technology evolves organic companies can impact the effectiveness.

Shes also concerned about the environment, rightly sayingthat this is the only earth we have and we can no longer turn a blind eye to the pesticides and herbicides are contaminating our soil and water systems.

In terms of Garniers Organic Range they are big believers that organic farming helps create a healthy living soil that is more resistant to drought, floods and consequently the impacts of climate change. Soil is a non-renewable resource; its preservation is essential for food security and our sustainable future. Organic production enhances soil life, natural soil fertility and water quality.

The organic formulators at Garnier are using ingredients (such as hemp in their new Skincare Restoring Range for stressed skin) that have stood the test of time and are proven to deliver results. When it comes to better skin, it makes sense to turn to nature for solutions.

Look for the Cosmos Organic logo and youll be helping to support the farmers and producers who work hard to grow our ingredients and look after our land for generations to come. By making One Small Swap to a certified organicproduct you can make a world of difference. Look out for the logo.

The benefits of holistic wellbeing includes doing our best to live a healthy lifestyles while doing our bit to take care of the environment.

First, there are scientific benefits to spending more time in nature such as reduction in anxiety and stress. Eating food as close to its natural state as possible, eating organically and shopping at local farmers markets to help reduce greenhouse gasses.

Holistic wellbeing bleeds out into beauty routines too:79% of people say that are more likely to buy a beauty product if it says organic.However, products may claim to be organic but, unlike organic food and drink businesses, beauty brands are not legally obligated to be certified and can claim to be organic even if they contain just 1% organic ingredients. Soil Association Certification means those products must contain 95% organic ingredients so look out for their logo on the packaging.

An intriguing element of holistic wellbeing is the mind-body connection, and a deeper understanding of the 360 experience of being human is integral to the founder of Pinks Boutique, Kirstie Sherriffs approach. She believes that you are not going to be able to fix your skin without changing negative thought patterns or sorting gut health. She is also adamant about the huge benefits of tackling stress, which on a physiological level dumps cortisol in the body, ups inflammation, and makes absorbing goodness from food harder.

Keeping an eye on holistic health includes making love, so when purchasing a lubricant, its important to consider what youre putting on your skin. Choosing to use products like YES that are organic and natural, are designed to match our bodies physiology to match the vaginal pH decreasing the risk of infection. Their natural ingredients including aloe vera, flax seed, cocoa butter, shea butter and calendula oil, whereas, non-organic sexual health products often contain parabens, glycerine, hormones and other known skin irritants such as glycols.

This is not a trend, its a way of life with increasing proof that living this way can increase energy, enhance wellbeing and help us to look healthier and more vibrant.

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The benefits of using organic beauty - Marie Claire UK

Everything You Need to Know About Period Tracking – Outside

Track your period andtrain smarter. That was the promise of FitrWoman, an app I downloaded on my phone last fall. Id decided to try it out because my fitness level seemed to drop off precipitously last year. Even though I was healthy and there were no major changes in my training, my endurance tanked. My joints and muscles were unrelentingly tight and brittle. My body didnt seem to recoverever. Id have one or two good weeks followed by a lackluster one where I could barely rally to run more than three miles and do some physical therapy exercises. The cycle repeated over and over.

All year, I tried every trick in the book to get back on track, but blindly following the advice of the latest fitness articles and sports research papers felt like a crapshoot (and not a very smart strategy). I was desperate for some concrete guidance. When nothing else seemed to help, I wondered if I should pay more attention to my hormones and menstrual cycle. Honestly, even though Ive written about the myriad ways that womens cycles can impact health and performance, I dont regularly think about it in the context of my own life. I dont compete at a high level, and I wasnt training for a goal race. I like to run, swim, practice yoga, and play outside as much as possible, and I wasnt sure my period really mattered. But Im in my early forties, and recentlymy period started acting finicky when it used to run like clockwork.

To the extent that I did think about my period, I considered it a liability when it came to sportsa nuisance at best, and a barrier to peak race-day results at worst. And Im not alone. A 2016 study in the journal PLOS Onefound that 55.4 percent of female athletes felt thattheir monthly cycle impacted their training or performance. However, menstruation is usually a taboo and embarrassing topic to discuss with friends, coaches, and teammatesso most women are left with few strategies to mitigate the effects of their cycle on their workouts except to grin and bear it. In fact, according to a 2019 analysis of responses from over 14,000 female Strava users, 72 percent said they have received no education about exercise and their periods.

Yetaccording to experts, understanding how women experience the menstrual cycle is fundamental to sports and performance. Womens physiology changes dramatically across the whole cycle, says Emma Ross, the former head of physiology for the English Institute of Sport, which supports British Olympic and Paralympic athletes. Hormones like estrogen and progesterone ebb and flow throughout the month, influencing everything from how women respond to training, metabolize nutrients, and regulate body temperature and hydration levels. In other words, my fueling needs and ability to recover from workouts may change depending on whether Im in a low-hormone phase or a high-hormone phase.

In an attempt to get to the bottom of why my fitness was stuck in the doldrums, I tracked my period for two months using two apps: Clue and FitrWoman.

According to experts, understanding how women experience the menstrual cycle is fundamental to sports and performance.

Lets back up for a minute. You may remember from biology class that there are two phases of the menstrual cycle. The first phase is the follicular phase, which kicks off when a woman starts her period: the body prepares to release an egg from an ovary and begins to rebuild the uterine lining. Generally, hormones are low during this period but start to rise. Ovulation occurs mid-cycle, when the egg is released. This marks the end of the follicular phase and the beginning of the luteal phase, when hormone levels are generally high and the body prepares to either accept a fertilized egg and support a pregnancy, or the body gets ready to shed the uterine lining.

In the past few years, researchers have begun to dig deeper into sex differences in sports science, with a particular focus on the impact of the menstrual cycle. There is mounting anecdotal evidencethat when you adjust training protocols to the specifics of female physiology, athletes perform better. The biggest endorsement for period tracking came last summer, when it was revealed that the U.S. Womens National Soccer Teamwho won ahistoric fourth World Cup lastJulytracked their cycles leading up toand during the tournament. The team implemented training, nutrition, recovery, and sleep strategies based on where each player was in their cycle. Chelsea F.C. Women (a womens soccer club based in England), the Brisbane Lions Womens team (an Australian Football League womens team), and others have also followed suit.

While recognizing monthly fluctuations can be useful, period tracking isnt a silver bullet. There isnt enough high-quality research to create evidence-based guidelines, especially given womens highly variable experiences with their period. In a Twitter thread, Kirsty Elliot-Sale, an associate professor at Nottingham Trent University and a researcher on female physiology, cautioned: We, the scientific community, have not yet reached a consensus on the direction or magnitude of changes that occur during the menstrual cycle and as such it is impossible for us to guide womens sport on this basis. (In July of this year, Elliott-Sale and her colleagues published a meta-analysis of the research on the menstrual cycle and exercise performance in the journal Sports Medicine, and called for further investigation because of the inconclusive results.)

However, menstrual cycle tracking can be an opportunity to empower women to appreciate their own physiology, says Dr. Ellen Casey, associate attending physiatristin the Womens Sports Medicine Center at the Hospital for Special Surgery in New York City. If its really true that risk of injury and performance fluctuates across the menstrual cycle, we can either say, That sucks, and not deal with it, or we can say, This is fascinating. Are there things we can learn from this? Can we harness these changes and train in certain ways at certain times?

In the past, most women have relied on pen and paper to keep tabs on their periods, if they did at all. Todaythere is no shortage of apps to help women understand their bodies better. Its all part of the booming femtech market, broadly defined as products, apps, and digital services centered around womens health and well-being. The category is projectedto be worth $50 billion by 2025, according to Frost andSullivan, a marketing consulting firm.

While most period-tracking apps are geared towardovulation and fertility, a growing numberlike Clue and Floallow women to log exercise and energy levels as well as more traditional symptoms like cramps and cravings. Garmin and Fitbit also offer period-tracking functions, so women can make notes on their cycle alongside their runs, bikes, and swims. MyFlo suggests different physical activities that may be more suited to the current phase of your cycle.The app then sorts through your data and looks for patterns and trends.

FitrWoman, which is targeted specifically to active women, takes things a step further: in addition to menstrual cycle and activity tracking, it provides educational snippets on whats happening in your bodybased on your current menstrual cycle phase, and offers strategies to mitigate those effects. On the home screen, you can swipe through a few slides and read how hormonal fluctuations may affect your physiology, training, and nutrition. Theres a link to recipes, too, which are tailored to support training and recovery for the phase youre in.

Each day, I opened the apps, clicked on the calendar (the main hub in both apps), and reported any symptomsI experienced that day. In FitrWoman, I scrolled a single page and chose from 20 different symptoms.

Clue, on the other hand, groups symptoms into nine categories (bleeding, pain, emotions, sleep, energy, cravings, digestion, mental, and exercise). Each category has four options: like cramps, headache, ovulation, and tender breastsfor pain; or happy, sensitive, sad, or PMSfor emotions. Just swipe and tap to log the relevant symptoms. I also have the option to create custom tags. Each month, I noted when my period started, its flow, and how long it lasted. The apps then predicted when my next period would start.

At first, chronicling daily symptoms was like starting a brand-new puzzle. I was excited to dig in and figure out what all the pieces would reveal about my physiology. For example, I noticed that I typically feel great in the follicular days between the end of my period and ovulation, when my hormone levels are relatively low. Im happy. I have plenty of energy. And I feel strong during my runs and strength sessions, so I can push myself harder.

On the flip side, during the luteal phaseI tend to feel flat, battle daily headaches, and have less energy and motivation to work out. This makes sense, since estrogen and progesterone levels are high, which can lead to bloating and fatigue. I also want to eat all the sweet and salty foods I can get my hands on during this time. We know that cravings are likely caused by increased insulin resistance in this phase, says Georgie Bruinvels, an exercise physiologist and the creator of FitrWoman. This can make blood-sugar levels more unstable. Instead of criticizing myself for being lazy and giving into my cravings, I was more proactive about fueling throughout the day to keep my blood sugar stable and switched up harder workouts for yoga, swimming, or a rest day during this phase.

Both apps also let women share information with their real-life coach. FitrWoman uses FitrCoach, a separate fee-based platform onwhich coaches can see where an athlete isin her menstrual cycle and which symptoms theyve logged. It also sends a notification if an athlete hasnt logged a period, which may be a sign of amenorrhea, the absence of menstruation. Amenorrhea can have a long-term impact on a womans health and signal the presence of a larger issue like the female athlete triad, or relative energy deficiency in sport (RED-S).

Since many women dont talk openly about their menstrual cycle, this setup can be a way to facilitate these private conversations, says Adam St. Pierre, an ultrarunning coach based in Boulder, Colorado. Previously, athletes would send him a text or email, or leave a note in their training log when they started their period or if they experienced troublesome symptoms. It wasnt super scientific, he says. FitrCoach allows for more tracking, letting me make sure things are going well. The equivalent setup for Clue is called Clue Connect: you can invite others to view your cycle, such as a coach, partner, family member, or friend. The app will show them the dates for your past, current, and predicted periods, fertile windows, and PMS. Other symptoms remain private.

While logging symptoms and collecting data about my cycle was easy, figuring out what it all meant and how I could apply it to my life wasnt so simple. Both apps provide educational information about menstruation and common symptoms, but the information is generic. I had to triangulate between FitrWoman, exercise physiologist and nutrition scientist Stacy Simss book Roar (the go-to training and nutrition guide for female athletes), and my own experience to determine which adjustments I could make and when.

There is currently no easy way to step back and get a macro-level view of my cycle and symptoms alongside my training log in either app. While FitrWoman syncs with Strava, I can only see that information for an individual day, not on a weekly or monthly basis. My basic activity stats (distance, pace, time, calories, elevation gain, etc.) automatically feed into my FitrWoman calendar and appear alongside symptoms Ive logged for that day. The data isnt pushed to my Strava feed. Plus, I normally use TrainingPeaks, not Strava, to track my workouts, and right nowthe app doesnt sync with TrainingPeaks. So I had to manually jump back and forth between all the apps, making it harder to see trends and process the overall picture of my health and performance. Bruinvels says FitrWoman plans to develop a higher-level view of the data over a longer time period and overlay it with training information. It may also move towardpredicting when symptoms are likely to occurbased on previous cycles. (The timeline for these developments isunclear.)

For its part, Clue does begin to analyze your reported data after you complete two cycles. It plots recurrent symptoms across each recorded cycleand predicts when youre likely to experience them based on past cycles. It also presents an overview: the average length of a cycle, the average length of a period, and the typical cycle length variation. Clues cycle analysis starts to get at the macro-level insights I craveand provides the data points to start piecing together the puzzle.

Admittedly, I wanted period tracking to be a fix, and to offer me a prescriptive path back to better fitness and strength. But its never that easy. Im still in the process of parsing out the data and testing different adjustments to get back on track.

Still, the simple act of noticing how I felt each day gave me a framework to interpret the signals my body was sending. Instead of berating myself for a bad run or lack of energy during strength workouts, I can put those workouts into context: Where am I in my cycle? Whats going on with my body that may make me feel this way? Should I expect to feel good today? NowI have a plausible explanation for how I feel, putting a stop to some of the second-guessing going on in my head.

Theres no part of the cycle thats negative, Sim says.Its about gaining awareness of how you are across your cycle and learning to work with that.

If you want to take a peek under the hood and understand your menstrual cycleand how it affects you, here are some tips to get you started.

Whether you use an app, a fitness tracker, or pen and paper, the first step is to commit to tracking your menstrual cycle and determine its length. Not every womans period is a textbook 28 days, Sims says. Cycle length can vary greatly from woman to woman, and even fluctuate from month to month. Even women at the same phase of their cycles can have vastly different experiences and symptoms, so its important to understand the influence of hormones in your own body.

Sims also recommends using an at-home ovulation predictor kit to determine when youre ovulating, especially if your app doesnt provide this information. (Clue does. FitrWoman doesnt.) This will tell you more precisely when youre entering the higher-hormone luteal phase of your cycle.

If youre taking hormonal birth control, its a little more complicated. For IUD users, you still experience natural hormonal fluctuations, even if you dont get a period, and can track your cycle and find your monthly patterns. However, if youre on combined hormonal birth control, you dont experience the same high- and low-hormone phases, since the contraceptive provides stable levels of estrogen and progesterone for three weeks out of every month. You can track, but youre not going to have the same benefit as if you were using your natural cycle, Sims says. While you may identify days when you feel good and bad, the whole concept of employing specific strategies for high-hormone versus low-hormone phases doesnt apply.

Sims recommends tracking your cycle for at least three months. This will begin to give you enough data so that you can start to see trends. If you track for one or two months, what you experience may just be an off day, she says. But if it happens three times, then you know there may be a real pattern. Overlay this information with your training log to spot connections between the menstrual cycle and workouts and races.

While the research isnt quite strong enough yet to make general recommendations, simply increasing your body literacy is beneficial. Ross, the UK-based physiologist, says that when youre in tune with the physical and emotional experience of your cycle, you may be more confident in planning your training, nutrition, and recovery, which can eliminate a lot of anxiety.

Once you notice patterns, begin to dial in your training and nutrition. It doesnt have to be prescriptive like, Im in a low-hormone phase so Im going to do high-intensity training this day, this day, and this day, Sims says. Instead, use those patterns as signals for when to ramp up activities or take things down a notch.

For example, during the high-hormone phase when women are likely to feel flat physiologically, its not the best time to work hard. Instead, focus on technique like running drills. With drills, you get the neuromuscular stimulus when the body is tired. Then, when you do the same drills when hormones are more optimal, youll perform that much better, says Sims.

While listen to your body feels like clich advice, its still a good mantra. Every womans experience is different across her cycle, and theres no one-size-fits-all template. Pay attention to whats happening and make reasonable adjustments based on your personal experience.

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Everything You Need to Know About Period Tracking - Outside

Powerful drug discovery protocol for autism is accelerating the development of new treatments – UB News Center

BUFFALO, N.Y. A sensitive and reliable new protocol for assessing social deficits in animal models of autism and certain psychiatric conditions is expediting the search for effective treatments. Developed by University at Buffalo researchers, the new protocol is described in a paper published today in Nature Protocols.

The protocol we developed is facilitating studies on social behaviors and mental disorders related to social impairment, said Zhen Yan, PhD, SUNY Distinguished Professor in the Department of Physiology and Biophysics in the Jacobs School of Medicine and Biomedical Sciences at UB and senior author on the paper.

She noted that a clinical trial for an autism treatment now underway by Oryzon, the European biopharmaceutical company, is, in part, based on preclinical studies conducted at UB with the protocol. That trial is focused on a form of autism called Phelan-McDermid Syndrome, which results from a single genetic deficiency in a gene called Shank3. The UB researchers have significantly contributed to the understanding of how that genetic mutation causes the social deficits.

Determining the effectiveness of a potential treatment for brain disorders cannot be done the way it is for many other diseases: by checking a biomarker in the blood or measuring tumor size and spread. The only way to determine how effective potential therapies for autism might be is to observe behavioral changes in preclinical models.

No biomarkers

We dont have a biomarker for autism, said Yan. Social deficits are the core symptom.

Thats why a sensitive and reliable protocol for measuring social deficits is so crucial to finding new autism treatments.

To find out whether a therapeutic strategy works or not, outcome measurements rely on behavior, Yan said. So a social preference protocol is a critical ingredient in determining the effectiveness of potential therapies in brain diseases like autism and certain mental disorders.

Social preference protocols for autism and similar conditions are based on the fact that normal animals will spend much more time interacting with a so-called social object, meaning another animal, than they will with a non-social, inanimate object, such as a block of wood.

In a mouse model of autism, this social preference will be significantly diminished, Yan said.

Assessing behavior changes

But assessing behavior changes in mouse models of autism isnt easy. A widely-used method for social preference has been a simple three-chamber assay, in which the test mouse is first habituated to an empty three-chamber apparatus. Then, one empty cup is placed in one side chamber, and another cup containing a mouse is placed in the other side chamber, and the amount of time spent interacting with either stimulus is recorded.

That type of test had an intrinsic bias, Yan explained. The social stimulus, which contains both a novel social stimulus (mouse) and a novel non-social stimulus (cup), is more salient than the non-social stimulus (cup alone), which may mask the presence of social preference deficits in autism models.

Similar protocols have produced inconsistent results, Yan said.

The protocol developed at UB is different for several reasons. The test mouse is first habituated to a three-chamber apparatus containing two empty cups in side chambers. The animal then is introduced to two identical inanimate objects (e.g. paper balls) placed within the cups. In the test phase, a social stimulus (mouse) is introduced under one cup and a novel non-social stimulus (e.g. wooden block) is placed under the other cup. The preference between social and non-social stimuli under conditions of equal salience is assessed.

Tests by Yan and her colleagues have demonstrated that this protocol successfully detects social preference deficits in several autism mouse models, and outperforms the widely-used method that differs in animal habituation and testing.

You need a measurement of the phenotype that is both sensitive and robust, and this protocol is both, said Yan.

Repeated measurements of social preference behavior using this protocol also enable longitudinal studies of therapeutic efficacy in autism models, as demonstrated by several publications from the Yan group.

Co-authors with Yan are Benjamin Rein, a doctoral candidate in neuroscience, and Kaijie Ma, research scientist, both in the Department of Physiology and Biophysics in the Jacobs School. The work was funded by the National Institutes of Health and the Nancy Lurie Marks Family Foundation.

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Powerful drug discovery protocol for autism is accelerating the development of new treatments - UB News Center

The truth about Tony Abbott – Spectator.co.uk

Last nights confirmation that Tony Abbott is joining the Board of Trade has been reported, bizarrely, with accusations that he is somehow misogynist or homophobic. There was little mention of why the British government actually headhunted him: his ability to achieve big free trade deals quickly. In his two years in office, he did more to help Australias exporters than any other leader in the countrys history, finalising free trade deals with what are (now) Australias three most important markets: Japan, China and Korea. He also initiated talks on a trade deal with the EU after his Labor predecessors lazily ignored the opportunity for years.

But as this is not very well known in Britain, its easier for critics to ignore it all and recycle these ridiculous claims. Who is there to come to his defence, given that no one really knows him in Britain? Who can give a different picture: about the nature of the man, or his qualification for the job? I was his international adviser for four years and I can tell you the British government has just recruited an eminently-qualified trade adviser. I can also tell you how little foundation there is behind those smears.

The claim that he is in some way a misogynist was most famously made by Australian Labor prime minister Julia Gillard in 2012 while Abbott was leader of the opposition. She dug up a partial quote from 1998 where he questioned why women were under-represented in positions of power. In debate, he had raised whether men are by physiology or temperament more likely to take jobs of authority.

The source? From 1998 when Abbott was at a round table that included Michael Costa, then a minister in New South Wales he wasnt making a statement but asking a question in a wide-ranging discussion.

Abbott: If its true that men have more power, generally speaking, than women, is that a bad thing?

Costa: Clearly its a bad thing.

Abbott: Why is that, Michael?

Costa: I want my daughter to have as much opportunity as my son.

Abbott: Yeah, I completely agree, but what if men are by physiology or temperament more adapted to exercise authority or to issue commands?

Costa: Well see, I dont believe that. What I do think is that we should never be in a situation where women have got to define their notions of success and self-worth by negating a traditional role. But in terms of the power structure I think its very hard to deny that there is an under-representation of women.

He was testing the fairly-common idea that men tend to chase top jobs a pretty far cry from declaring that men are best-suited for the top jobs.

Gillard also attacked him for comments he made once on a visit to the town of Queanbeyan outside Canberra, warning of higher electricity prices under her governments emissions trading scheme and trying to express that in household consumption terms. What the housewives of Australia need to understand as they do the ironing is that if they get it done commercially it's going to go up in price, and their own power bills when they switch the iron on, are going to go up, he said. Perhaps this underestimated the role of men of Queanbeyan who doubtless do a lot of ironing. But does it expose the black heart of a sexist?

Gillards characterisation of Abbotts views of womens roles was obviously dishonest. In fact the womens rights issue he was criticised for most at the time was his championing of a plan to improve the rights of working women by introducing what would have been one of the worlds most generous paid parental schemes, providing six months of leave on full wages for one parent in all couples (including those of the same sex). Gillard opposed the scheme and it was later shelved for reasons of cost.

Her charge that Abbott was somehow opposed to power being given to women is undermined by the fact that one of the major elements contributing to his losing the prime ministership was the widespread view that he had given his female chief of staff Peta Credlin too much power. Despite mounting calls for him to sack her, including from Rupert Murdoch, he remained staunchly loyal.

Gillard also liked to quote something he said speaking at Adelaide University in 2004 on the ethical role of a Christian politician. How to understand the high number of abortions, he said? Well, you can consider some of the personal circumstances. To a pregnant 14-year-old struggling to grasp whats happening, for example, a senior student with a whole life mapped out or a mother already failing to cope under difficult circumstances, abortion is the easy way out. Its hardly surprising that people should choose the most convenient exit from awkward situations. What seems to be considered far less often is avoiding situations where difficult choices might arise. So he was advocating alternatives to unwanted pregnancy in the first place. But this sentence in this speech has been truncated by his critics to six words: abortion is the easy way out.

Abbott gets on well with Boris Johnson, and shares with the British prime ministers refusal to be strait-jacketed by politically-correct language rules. Ten years ago, for example, when enumerating the qualities of one of his partys female candidates, he included sex appeal among them. This may have made him seem old-fashioned, but the woman in question found it amusing and the comment could hardly be construed as misogyny.

Abbott has also been accused of being a homophobe for two television interviews in 2010 when he was being frank about his own feelings. He said he had once felt a bit threatened, as most people do by homosexuality because there is no doubt that it challenges, if you like, orthodox notions of the right order of things. Again, there can be little doubt that these views were influenced by his Catholicism were talking about a man who once trained to be a priest. But in the same interview, he said: it's a fact of life and we have to treat people as we find them. If you bought the Emily Thornberry or Kay Burley view of Abbott, youd also be surprised to learn that when one of his longtime friends transitioned from male to female, she asked Abbott to introduce a documentary about her story. He gladly did so.

In 2017 Abbott became the de facto leader of the opposition case for legalising same-sex marriage ahead of Australias referendum on the issue, arguing that it is not homophobic to maintain that, ideally, children should have both a mother and a father. That was much more gentle than the line of Australian Labor hero, former prime minister Paul Keating, who said that two blokes and a cocker spaniel dont make a family. But as a hero of the left, unlike Abbott, Keatings never been attacked as a bigot over the issue. After Australia voted yes to legalising same sex marriage, Abbott was again pragmatic. When his lesbian sister Christine Forster married the following year, Abbott sat in the front row and commented that it was a great family occasion, that he was very happy for his sister and her spouse and that he was looking forward to having a new sister-in-law. Forster has issued a statement calling the claims of misogyny and homophobia dishonest, describing her brother as an unabashed conservative but with great compassion, respect for others and an indelible sense of doing whats right.

Beyond Abbotts undoubted achievements, all who have had the privilege of working with him know that it would be hard to find a more decent, likeable or good-humoured figure in public life. And one of the qualities his detractors would prefer was ignored is his decades-long commitment to working to improve the life of the first Australians. The left likes to claim concern for the generally disadvantaged Aborigines as its issue. But Abbott, unlike any other senior political figure, over many years has stayed at remote Aboriginal communities on a regular basis including when prime minister to explore ways in which their welfare could be improved. Britain is lucky to have him.

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The truth about Tony Abbott - Spectator.co.uk

Pinning down the size of big tooth shark Megalodon – Gulf Times

If the serrated sharp teeth of a killer shark invaded the dreams of millions of movie buffs across the world 45 years ago when acclaimed director Steven Spielberg released his cult Hollywood film Jaws, the scientifically inaccurate The Meg refreshed those memories in 2018 by telling a story about a 75ft prehistoric shark, the Megalodon. So much for fiction, and now it is time to cut to reality. To date only the length of the legendary giant shark Megalodon had been estimated but, a new study led by the University of Bristol and Swansea University has revealed the size of the rest of its body, including fins as large as an adult human.There is a grim fascination in determining the size of the largest sharks, but this can be difficult for fossil forms where teeth are often all that remain. Today, the most fearsome living shark is the Great White, at over 6m (20ft) long, which bites with a force of two tonnes. Its fossil relative, the big tooth shark Megalodon, lived from 23 to around 3mn years ago, was over twice the length of a Great White and had a bite force of more than 10 tonnes. The fossils of the Megalodon are mostly huge triangular cutting teeth bigger than a human hand.Jack Cooper, who has just completed the MSc in Palaeobiology at the University of Bristols School of Earth Sciences, and colleagues from Bristol and Swansea used a number of mathematical methods to pin down the size and proportions of this monster, by making close comparisons to a diversity of living relatives with ecological and physiological similarities to Megalodon. The project was supervised by shark expert Dr Catalina Pimiento from Swansea University and Professor Mike Benton, a palaeontologist at Bristol. Dr Humberto Ferrn of Bristol also collaborated. Their findings have been published the other day in the journal Scientific Reports.Previously the fossil shark, known formally as Otodus megalodon, was only compared with the Great White. Jack and his colleagues, for the first time, expanded this analysis to include five modern sharks. Dr Pimiento said: Megalodon is not a direct ancestor of the Great White but is equally related to other macropredatory sharks such as the Makos, Salmon shark and Porbeagle shark, as well as the Great White. We pooled detailed measurements of all five to make predictions about Megalodon.Professor Benton added: Before we could do anything, we had to test whether these five modern sharks changed proportions as they grew up. If, for example, they had been like humans, where babies have big heads and short legs, we would have had some difficulties in projecting the adult proportions for such a huge extinct shark. But we were surprised, and relieved, to discover that in fact that the babies of all these modern predatory sharks start out as little adults, and they dont change in proportion as they get larger.As Jack Cooper said, this meant, the researchers could simply take the growth curves of the five modern forms and project the overall shape as they get larger and larger right up to a body length of 16m. The results suggest that a 16m long Otodus megalodon likely had a head round 4.65m long, a dorsal fin about 1.62m tall and a tail around 3.85m high. This means an adult human could stand on the back of this shark and would be about the same height as the dorsal fin.The reconstruction of the size of Megalodon body parts represents a fundamental step towards a better understanding of the physiology of this giant, and the intrinsic factors that may have made it prone to extinction.

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Pinning down the size of big tooth shark Megalodon - Gulf Times

Matthew Watt – The Conversation AU

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Professor Matthew Watt heads the Department of Physiology at the University of Melbourne. His teams innovative research program seeks to identify how defects of lipid metabolism and inter-tissue communication cause obesity-related disorders, and to use this information to discover novel targets that can be transitioned to clinical therapeutics. Professor Watt has authored >180 peer-reviewed manuscripts and contributed to the discipline through his roles as National Secretary of the Australian Physiological Society and as a reviewing editor of the American Journal of Physiology (Endocrinology & Metabolism).

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Matthew Watt - The Conversation AU

Cell-autonomous immunity and the pathogen-mediated evolution of humans – Science Codex

Although immune responses are generated by a complex, hierarchical arrangement of immune system organs, tissues, and components, the unit of the cell has a particularly large effect on disease progression and host survival. These cell-level defense mechanisms, known as cell-autonomous immunity, are among the most important determinants of human survival, and are millions to billions of years old, inherited from our prokaryotic and single-celled ancestors.

The authors of a new paper published in the September 2020 issue of The Quarterly Review of Biology argue that understanding how cell-autonomous immunity has evolved in primates is crucial to understanding the human evolution, not only because infectious agents thought to have affected human genomic evolution are excellent manipulators of cell-autonomous immunity, but because these defenses are found in every cell in every body system.

In "Cell-Autonomous Immunity and the Pathogen-Mediated Evolution of Humans: Or How Our Prokaryotic and Single-Celled Origins Affect the Human Evolutionary Story," Jessica F. Brinkworth and Alexander S. Alvarado discuss how the ubiquity of cell-autonomous immunity highlights a biological reality not commonly addressed in human evolutionary studies - pathogens can mediate the evolution of all body cells, and therefore, all human body systems.

The article examines these ancient tactics in light of evolutionarily important human pathogens and illustrates inter-primate differences in their function. The authors posit that, often considered an independent physiological system in human evolutionary biology, the immune system is ubiquitous, integrated into every other aspect of human physiology. "We argue, therefore, that immunity and pathogen-mediated natural selection is a consideration in the examination of the evolution and function of any human physiological system or trait."

The authors show how human pathogens considered important in the evolution of the human genome manipulate cell-autonomous immunity and have shaped primate evolution, including phagosomes like Yersinia pestis (the causative bacteria of plague) and antimicrobial peptides like Toxoplasma gondii, the 1-2 million-year-old obligate intracellular feline-borne parasite.

"The ancient nature of these defenses is an important consideration in human evolutionary studies because their antiquity is both why cell-autonomous immunity exists in every cell, and the pathogens commonly considered the most pernicious and to have exerted the most stringent selective pressure on the human lineage tend to be organisms that bear microbiological innovations that manipulate these tactics," the authors write.

The paper also illustrates that these defenses are diverging in primate immune cells, and present evidence that they are also changing in "nonimmune" tissues. "For decades, it has been understood that microorganisms and cell-autonomous immune responses to them alter human behavior and vice versa. Incorporation of the same biological relationships between pathogens, cell-autonomous defenses, and body system X extended to other physiological systems or traits at the center of the classic questions of human evolutionary biology (e.g., why does skin color vary in humans, why do primate placentae vary in shape and size, how did human bipedal locomotion evolve, how does primate bone and dental microstructure vary) can enrich and improve our understanding of why such features evolved."

For this kind of information to contribute to a better understanding of the gross features of human evolution, however, the authors say researchers in this area must increase integration of molecular and morphological methods or findings in human evolutionary studies. "Any examination of human evolutionary biology, regardless of physiological system and when possible, should consider autonomous immunity of the cells in that system and how microorganisms have shaped them."

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Cell-autonomous immunity and the pathogen-mediated evolution of humans - Science Codex