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With careful adoption, soy and wheat can help maintain seniors’ muscles, says expert – Clinical Daily News – McKnight’s Long Term Care News

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Plant protein can help older adults maintain muscle mass, but users must adjust for any loss of animal protein when making dietary changes, say researchers.

In a new study, plant-based proteins helped to maintain the size and quality of aging muscles, wrote investigators from Kings College London. But animal proteins were more effective at helping to form muscle. A larger dose of plant protein is therefore necessary to achieve the same muscle-building response, they concluded.

Simply transitioning from an animal-based protein diet to a plant-based diet, without adjusting total protein intake, will likely be detrimental to muscle health during aging, said Professor Oliver Witard, an expert in exercise metabolism and nutrition. A more balanced and less extreme approach to changing dietary behavior, meaning eating both animal and plant-based proteins, is best, he concluded.

Plant-based diets have numerous health benefits and are becoming more popular. In fact, 39% of Americans responded that they are actively trying to eat more plant-based foods, according to a 2017 Nielsen Homescan survey.

The research was presented this week at The Physiological Societys virtual early career conference Future Physiology 2020.

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With careful adoption, soy and wheat can help maintain seniors' muscles, says expert - Clinical Daily News - McKnight's Long Term Care News

Fluence Leads Global Research Initiative to Study Impact of Light Quality on Plant Development, Yield and Crop Quality – Financial Post

The ongoing multi-country and multi-crop initiative advances Fluences and the greater horticultural industrys understanding of the interaction between light and life

AUSTIN, Texas Fluence by OSRAM (Fluence), a leading global provider of energy-efficient LED lighting solutions for commercial cannabis and agriculture production, has expanded its global photobiology research program, which encompasses studies on multiple vine crops, leafy greens and medical cannabis in the United States, Canada, Germany, Belgium and the Netherlands.

Tapping into a global network of trusted research institutions

Fluence leverages a network of leading research institutions and partners for its program, including Wageningen University & Research (WUR) for tomatoes; Proefstation voor de Groenteteelt (Proefstation) to study cucumbers; Harrow Research and Development Centre for peppers; The Technical University of Munichs Greenhouse Lab Centre for lettuce; Wageningen Plant Researchs Greenhouse Horticulture business unit and Compassionate Cultivation for medical cannabis.

The latest studies utilized Fluences VYPR Series top light and expanded PhysioSpec spectra offeringwhich features four spectra and market-leading efficacies up to 3.8 mol/Jin a randomized block design with triple replicates during a winter growing season. A leader in global horticultural research, WUR explored the impact of each spectrum on Merlice and Brioso tomato cultivars.

Traditionally, tomato plants are grown under high-pressure sodium lights, where only one spectrum is available to growers, said Ep Heuvelink, associate professor of horticulture and product physiology at WUR. Given the efficacy of Fluences LED solutions and the companys spectra options, its critical to understand how various tomato cultivars perform under LEDs and diversified spectra.

Featuring a 1.3-hectare greenhouse with 38 independent compartments, Proefstations facility brings more than 50 years of experience in research on the cultivation of greenhouse and field vegetables.

Light spectra have an important impact on plant and fruit quality, and weve found that LEDs provide a more optimal, precise spectrum than HPS, said Jonas De Win, lead cucumber researcher at Proefstation. This research is critical for our growers who frequently ask which spectra is best for their greenhouse and crop variety. Our goal is to act as the bridge between cucumber growers and the latest scientific research, enabling cultivators to enhance their environments and ultimately become more profitable.

Crop-based research results inform unique lighting strategies

LED lighting is a proven, viable option for global crop growers, said David Cohen, CEO of Fluence. Our exploration of the impact of light quality on plant development is driving a deeper conversation about efficacy, yield and quality between growers and their partners. Our commitment to leading cross-geography, multi-crop research will help guide growers in building a supplemental lighting strategy tailored to their unique business goals.

Fluence will distribute research results throughout the year, uncovering how the optimal lighting strategy varies by crop, species and environment. Results from Fluences cucumber trial with Proefstation will be previewed on July 15, 2020 on a webinar hosted by Leo Lansbergen, Fluences horticulture service specialist and expert in cucumber cultivation.

There is no one-size-fits-all approach to determining your lighting strategy, said David Hawley, Ph.D., Fluences senior scientist. Exploring how to manipulate LED technology presents a world of opportunity for us as scientists, but ultimately benefits growers looking to customize their cultivation environments. Insights derived from each study will help growers understand how various spectra impact harvests and plant quality, including factors ranging from nutrition and flavor to shelf life.

For more information about Fluence and its ongoing research initiatives, visit http://www.fluence.science.

About Fluence by OSRAM

Fluence Bioengineering, Inc., a wholly-owned subsidiary of OSRAM, creates powerful and energy-efficient LED lighting solutions for commercial crop production and research applications. Fluence is a leading LED lighting supplier in the global cannabis market and is committed to enabling more efficient crop production with the worlds top vertical farms and greenhouse produce growers. Fluence global headquarters are based in Austin, Texas, with its EMEA headquarters in Rotterdam, Netherlands. For more information about Fluence, visit http://www.fluence.science.

Link to high resolution pictures: http://www.fluence.science/press-links

View source version on businesswire.com: https://www.businesswire.com/news/home/20200708005470/en/

Contacts

Media Contact: For North America, Emma Chase emma@redfancommunications.com Phone: 512-917-4319

For EMEA, Silvia Nagyova s.nagyova@osram.com Phone: +49 (89) 6213-3939

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Fluence Leads Global Research Initiative to Study Impact of Light Quality on Plant Development, Yield and Crop Quality - Financial Post

Cue Biopharma Announces PLOS One Publication Demonstrating the Generation and Evaluation of Novel Molecules with Directed Mutations within the B7…

- Novel insights into receptor binding events and interfaces have led to generation of selective molecules with unique biochemical and functional properties through an effort led by Dr. Steven Almo at Albert Einstein College of Medicine

- Enhances Cue Biopharmas ability to engineer molecules for therapeutic immune modulation through Immuno-STAT and Neo-STAT platforms

CAMBRIDGE, Mass., July 08, 2020 (GLOBE NEWSWIRE) -- Cue Biopharma, Inc. (NASDAQ: CUE), a clinical-stage biopharmaceutical company engineering a novel class of injectable biologics to selectively engage and modulate targeted T cells within the body, today announced the peer-reviewed publication of data focused on generation and evaluation of libraries of checkpoint molecules with directed mutations providing novel biological properties in a paper titled Mechanistic dissection of the PD-L1:B7-1 co-inhibitory immune complex.

In this work, researchers focused primarily on the recently described interaction between B7-1 and PD-L1, two molecules within the B7 superfamily, which are of critical importance for controlling anti-tumor immunity, autoimmunity and infectious diseases. By combining cell microarray and high-throughput FACS methods to screen binding events and map binding interfaces, selective mPD-L1 and mB7-1 mutants with distinct biochemical and functional properties were generated that altered the binding interactions between PD-1 and PD-L1, and CTLA-4 and B7-1 as well as the recently described PD-L1 and B7-1 binding interaction.

Our efforts expand upon the fundamental understanding of critical binding interactions and related downstream signaling cascades by more completely defining the molecular interactions between these key cell surface molecules, said Steven C. Almo, Ph.D., professor and chair of biochemistry, professor of physiology & biophysics and the Wollowick Family Foundation chair in multiple sclerosis and immunology at Albert Einstein College of Medicine, and co-founder of Cue Biopharma. Through these studies we are able to decipher specific molecular and atomic insights to engineer and generate molecules with unique biochemical and functional properties with the aim of developing more efficacious treatments with fewer unwanted side effects.

This approach augments and supplements Cue Biopharmas Immuno-STAT and Neo-STAT platforms, leveraging rational protein engineering to generate therapeutic frameworks possessing desirable drug properties while attenuating and/or abrogating unwanted, deleterious effects. CUE-101, Cue Biopharmas lead asset from the IL-2 based CUE-100 Series, was rationally engineered to enhance the selective activation of the beneficial CD8+ anti-tumor T cells, while abrogating the effects on other immune cell populations that are deleterious to cancer therapy, such as regulatory T cells. A CUE-101 Phase 1 monotherapy trial is ongoing, with enrollment of patients in dose escalation at 13 leading centers in the United States for the treatment of post first-line metastatic and recurrent HPV+ advanced head and neck cancer. Early data metrics from this trial are encouraging with demonstration of safety and tolerability, dose proportional exposure pharmacokinetics (PK) and early, albeit anecdotal, evidence of biologic activity through pharmacodynamics (PD) biomarkers and clinical benefit.

We are highly encouraged by these findings and further research being conducted in Dr. Almos laboratory, which provides us with additional, novel insights into immune receptors, said Anish Suri, Ph.D., president and chief scientific officer of Cue Biopharma. Learnings from this important work will augment and further advance our internal efforts to build out the Immuno-STAT and Neo-STAT platforms and enhance our ability to dial-in/dial-out specific molecular interactions for the therapeutic modulation of the immune system in cancer, autoimmune diseases and chronic infectious diseases.

Albert Einstein College of Medicine and its faculty members acknowledge the following relationships with Cue Biopharma, Inc.: Dr. Almo holds equity in Cue Biopharma, Inc., receives royalties from existing license agreements between Einstein and Cue,and is a member of its Science Advisory Board; Dr.Garrett-Thomson receives royalties; and Albert Einstein College of Medicine holds equity in Cue and receives royalties.

AboutCue BiopharmaCue Biopharma, a clinical-stage biopharmaceutical company, is engineering a novel class of injectable biologics to selectively engage and modulate targeted T cells within the body to transform the treatment of cancer and autoimmune diseases. The companys proprietary platform, Immuno-STAT (Selective Targeting and Alteration of T cells) is designed to harness the bodys intrinsic immune system without the need for ex vivo manipulation.

Headquartered inCambridge, Massachusetts, we are led by an experienced management team and independent Board of Directors with deep expertise in the design and clinical development of protein biologics, immunology and immuno-oncology.

For more information, visitwww.cuebiopharma.comand follow us on Twitter https://twitter.com/CueBiopharma.

Forward-Looking StatementsThis press release contains forward-looking statements within the meaning of Section 27A of the Securities Act of 1933, as amended, and Section 21E of the Securities Exchange Act of 1934, as amended, that are intended to be covered by the safe harbor created by those sections. Forward-looking statements, which are based on certain assumptions and describe our future plans, strategies and expectations, can generally be identified by the use of forward-looking terms such as believe, expect, may, will, should, would, could, seek, intend, plan, goal, project, estimate, anticipate, strategy, future, likely or other comparable terms. All statements other than statements of historical facts included in this press release regarding our strategies, prospects, financial condition, operations, costs, plans and objectives are forward-looking statements. Examples of forward-looking statements include, among others, statements we make regarding anticipated results of our drug development efforts, including study results, and our expectations regarding regulatory developments and expected future operating results. Forward-looking statements are neither historical facts nor assurances of future performance. Instead, they are based only on our current beliefs, expectations and assumptions regarding the future of our business, future plans and strategies, projections, anticipated events and trends, the economy and other future conditions. Because forward-looking statements relate to the future, they are subject to inherent uncertainties, risks and changes in circumstances that are difficult to predict and many of which are outside of our control. Our actual results and financial condition may differ materially from those indicated in the forward-looking statements. Therefore, you should not rely on any of these forward-looking statements. Important factors that could cause our actual results and financial condition to differ materially from those indicated in the forward-looking statements include, among others, our limited operating history, limited cash and a history of losses; our ability to achieve profitability; potential setbacks in our research and development efforts including negative or inconclusive results from our preclinical studies, our ability to secure requiredU.S. Food and Drug Administration(FDA) or other governmental approvals for our product candidates and the breadth of any approved indication; adverse effects caused by public health pandemics, including COVID-19, including possible effects on our operations and clinical trials; negative or inconclusive results from our clinical studies or serious and unexpected drug-related side effects or other safety issues experienced by participants in our clinical trials; delays and changes in regulatory requirements, policy and guidelines including potential delays in submitting required regulatory applications to theFDA; our reliance on licensors, collaborators, contract research organizations, suppliers and other business partners; our ability to obtain adequate financing to fund our business operations in the future; ; and the other risks and uncertainties described in the Risk Factors and in Management's Discussion and Analysis of Financial Condition and Results of Operations sections of our most recently filed Annual Report on Form 10-K and any subsequently filed Quarterly Report(s) on Form 10-Q. Any forward-looking statement made by us in this press release is based only on information currently available to us and speaks only as of the date on which it is made. We undertake no obligation to publicly update any forward-looking statement, whether written or oral, that may be made from time to time, whether as a result of new information, future developments or otherwise.

Investor ContactAshley R. RobinsonLifeSci Advisorsarr@lifesciadvisors.com

Media ContactAlison ChenLifeSci Communicationsachen@lifescicomms.com

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Cue Biopharma Announces PLOS One Publication Demonstrating the Generation and Evaluation of Novel Molecules with Directed Mutations within the B7...

Anatomage Announces Its Upcoming eBook For Students To Experience and Interact with True-Human Cadavers Online – WFMZ Allentown

SAN JOSE, Calif., July 2, 2020 /PRNewswire/ -- Anatomage Inc, a market leader in 3D medical imaging technology, today announces Anatomage eBook - an eBook that enables students to study anatomy and physiology through interacting with the anatomy of true-human cadavers online.

Anatomage eBook consists of 25 chapters that feature major anatomy and physiology concepts of 12 major body systems and functions. For each concept, users are visually guided through all of the related body parts - from macro to microstructures - with educational texts and dynamic images. As the majority of images from Anatomage eBook stem from the Anatomage Table's true-human cadavers, the digital contents exhibit accurate human anatomy content that helps students decipher and memorize anatomical terms easier.

Anatomage eBook is optimized for online learning which allows students to access the contents from anywhere. Unlike other online tools, the eBook offers a unique user experience that is highly engaging and easy to navigate. The contents are highly visual and based on Anatomage's renowned photorealistic human data.

Modeled as a dynamic web-based textbook, Anatomage eBook produces an interactive, aesthetically pleasing interface where students can explore a variety of anatomy and physiology topics using interactive controls. From tapping on the screen to scrolling the mouse, users are able to navigate through diverse anatomical parts. Adjacent and tiny structures are also highlighted with colors for distinguishment. Furthermore, cadaveric models can be rotated and engaged for a better view. Given its high interactivity, Anatomage eBook efficiently transforms the clinical and anatomical terminology into illustrative learning visuals that enhance students' memory.

Anatomage eBook is an effective learning tool for undergraduate Anatomy & Physiology students. To assist with assessing student learning, questions are included for various key topics in the textbook. Since Anatomage eBook can be accessed anywhere with Internet connectivity, it can be used as an online learning tool for both in-class and self-study sessions. By offering a multimedia platform combined with its accurate anatomy and physiology representation, Anatomage eBook embodies a new standard for digital textbooks in the medical education industry.

Adopting the Anatomage eBook will enable your students to -

For more information, please visit here or contact info@anatomage.com.

About AnatomageAs a market leader in medical virtualization technology, Anatomage enables an ecosystem of 3D anatomy hardware and software, allowing users to visualize anatomy at the highest level of accuracy. Established in both education and healthcare industries, Anatomage is transforming standard anatomy learning, medical diagnosis and treatment planning through its highly innovative products.Contact:Jack ChoiCEOAnatomage Inc.Phone: 1-408-885-1474Email: info@anatomage.comwww.anatomage.com

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Anatomage Announces Its Upcoming eBook For Students To Experience and Interact with True-Human Cadavers Online - WFMZ Allentown

The psychology and physiology of pain management in athletics – AW – Athletics Weekly

Gateshead International Athletics Stadium, July 31, 1983

With just one week to go before the inaugural World Championships in Helsinki, some of the sports top names are fine-tuning their preparations before jetting off to Finland.

As a bridging distance between 800m and 1500m, the mens 1000m has attracted an international field of half milers and milers. As they take the bell in a respectable 1:26.58, a familiar face on the European circuit is leading in his distinctive white vest and matching wristbands.

Down the back straight for the last time and BBC Grandstand commentator David Coleman is waxing lyrical about the virtues of the elegant striding American out in front. This being said, the man who will go on to record a lifetime best of 1:44.62 over two laps in Stockholm a year later is most certainly a specialist half miler and the rolling of his head as the 800m point fast approaches, signals an impending changing of the guard.

At that moment, Moscow Olympic 800m champion Steve Ovett predictably devastatingly kicks and opens up a gap on the field with Don Paige giving dogged, if eventually futile, chase over the final 200 metres. An unflustered Ovett stops the clock at 2:19.06, saving his customary wave to the crowd until after the finishing line on this occasion.

Further down the field, the battle for the minor places continues as 1976 Olympic 1500m champion John Walker edges past the long-time race leader, whose shoulders have by now joined his head in rotational motion and who will eventually finish in fifth place.

Thirty-seven years later, laughing as he recalls his capitulation over the final furlong, James Mays jokes: I was left looking like the coyote in an episode of Wile E. Coyote and the Road Runner! His lay citation to matters of the zoological continue as comparisons to a North American species of canine are soon superseded by reference to a mammal namely monkeys.

The man who achieved international recognition for his pacemaking work in the 1980s, which famously included guiding Steve Cram to a world mile record in Oslo in the summer of 1985, recalls: When I was running at Texas Tech, my team-mates coined the phrase Monkey City. I thought it was funny and a great description of how a runner feels when theyre in the final push of a race.

The thought of monkeys riding your back with the sound of eek, eek in your ear was quite amusing!

In his moment of jest, the three-time All American collegiate champion may well be speaking words of truth and offering us a few hidden gems in terms of both the psychology and physiology of pain management among athletes.

The sensation of pain occurs as a result of brain neuronal activity in the encephalon. The experience of pain is of course unpleasant but a necessity when one considers its vitality as a signalling function which enables us to ultimately avoid death and maintain homeostasis in biological terms.

The functionality of pain is that it serves as an adaptive function, allowing us as athletes to know when we have encountered our optimal load, be it in the realms of running, jumping or throwing. In disaggregating the notion of pain, Domzal (1996) spoke about three facets in terms of the somatic (sensual feeling), the cognitive (psychological) and emotional (which is the value judgement we place on pain). This is compatible with the work of Azevedo and Samulski (2003), who noted that while athletes seem to have pain thresholds similar to non-athletes, critically their tolerance to pain may well be higher. So in essence, its not what we experience biologically, but how we perceive that experience psychologically.

Pain is subjective and relative which is why the man who now teaches both at school and university level in his native Dallas continues: Of course there are times when you dont feel like youre attacked by monkeys, but actual gorillas!

What Mays might be referring to would be classified by the likes of Haythornwaite et al (1998) as a specific form of coping strategy for pain management. Rather than ignoring Monkey City, Mays recollections of that Gateshead race challenge us as to whether we should adopt a strategy of Mindfulness based upon acceptance that as endurance-based athletes, at some point in our races we will inevitably feel as if we live in such a frightening urban metropolis. This again has some support from the sports psychology literature in that Salwin and Zajac (2016) perceptively point out: Knowing when to expect the difficulties makes it easier for the competitor to prepare and overcome them This means that an athlete can, to a certain degree, prepare for pain.

So rather than running away from pain, we should actually be prepared to hug and embrace it.

While psychologically it clearly helped an athlete like Mays to objectify and externalise his pain as a monkey, references to Monkey City were shared among his collegiate athlete community. This means they must be understood at the sociological level because shared humour is subcultural and its learned behaviour.

This is no surprise in that pain is central to our sport. The ability to joke about pain is functional for us athletes and there is of course a plethora of literature around how humour can keep us well both psychologically and biologically (See Hassed, 2001). Humour is a necessity, not during a race but certainly when embarking upon the slog of training its a defence mechanism against quitting.

While psychologically accepting that one will encounter pain, elite level performers like Mays will always attempt to develop physiological strategies to try and deal with the build-up of acid in their blood which is one of the biological drivers of the psychological experience of inhabiting Monkey City.

In recent years, the esteemed Oregon-based coach Peter Thompson (see http://www.newintervaltraining.com) has done much good work to further the understanding of what exercise physiologists would term acidosis. When lactic acid is formed it dissociates into lactate and acid, the latter of which is formed of hydrogen ions. At the point at which the production of hydrogen ion exceeds the bodys ability to buffer and clear because the kidneys and lungs cant keep the systems pH in balance, acidosis is said to occur and thus athletes enter the gateways of Monkey City.

At the appropriate point of the periodisation cycle, intense training simply has to be performed in order to both physically and psychologically prepare both body and mind to cope with the accumulation of high amounts of hydrogen ions, which may be perceived as Monkey City in experiential terms.

In previous decades, coach education discourses have incorrectly termed this as lactate tolerance training. The aforementioned Thompson perceptively points out that a more useful term is in fact acidosis tolerance training because lactate itself can be functional for the body.

So how did Mays prepare in terms of the specificity of his own acidosis tolerance training for his visit to Monkey City?

The workout that I did which best prepared me to negotiate Monkey City was a 600m speed endurance, he says. I would run to the 600m mark and then jog 150m through the curve, turn around and jog back to the 200m start. At that point I would blast the final 200m.

I would do three sets of those and at the end I was totally exhausted but it simulated in the 800m and I felt it prepared me to compete at a higher level.

The work of the late national coach for middle-distance, Dave Sunderland (2005), would frame this as an event specific session. The three golden rules of this mode of session are (1) that each set always adds up to the target race distance; (2) that work is grouped into sets in order to allow sufficient recovery to undertaken work which challenges the lactate energy system; and (3) that second and/or third set repetition lengths tend to be shorter the than first set.

So it should be noted that Mays practice of this type of session included a differential element in terms of pacing namely that the 200m effort would be effected at a greater average pace than that over 600m. Additionally, unlike the doctrine offered by Sunderland (2005), he has undertaken sets of the same length of repetitions. So while Mays has deviated from a textbook way of undertaking event specific repetitions, he has done so in a way which serves his own individual developmental needs while remaining faithful to the underlying ethos or spirit of this mode of session.

So while Mays was a world-class 800m runner, lets take Sunderlands example of a world-class 1500m runner aiming to hypothetically run 3:30 first set = 500m (70s); 1 min recovery; 700m (98s); 30 sec recovery; 300m (42s) 15-20 min recovery. Second set = 5x300m (42s) 1 min recovery between repetitions.

The strengths of using the kind of event specific repetitions utilised by the man who was a regular for Team USA in the 1980s, along with the likes of Johnny Gray and Earl Jones, are that they are invaluable preparation for ones visit to Monkey City. The cautionary note is that this mode of session tends to be effected in the competition phase of the periodisation cycle only. This mode of session cannot be performed consistency over several months due to the considerable demands on the lactate energy system and excessive use will risk the kind of fatigue which can lead to both subsequent loss of form and potential injury.

The moral of the story is if you want to deal with the monkey on your back it is well worth having a natter to the man affectionately known as The Rabbit!

Questions for self-reflection

Matt Long is a former winner of the British Milers Club Horwill Award for Coach Education and the author of more than 250 coaching articles.He can be contacted at [emailprotected] for advice on this piece

For more on the latest athletics news, athletics events coverage and athletics updates, check out theAW homepageand our social media channels onTwitter,FacebookandInstagram

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The psychology and physiology of pain management in athletics - AW - Athletics Weekly

U of A ranked among world’s top energy research universities – Folio – University of Alberta

The University of Alberta is among the worlds best, if not the best, energy research universities according to an updated version of the QS World University Rankings by Subject, which also placed the U of A in the top 10 of sport-related subjects for the fourth year in a row.

The amended 2020 version of the subject rankings saw the U of A land in the top 50 in three new energy-related categoriespetroleum engineering (eighth), geophysics (46th) and geology (50th)to go with a previous 11th-place ranking in mining and minerals.

Clayton Deutsch, director of the U of As School of Mining and Petroleum Engineering, said part of the programs success is the impact alumni are having on the mining industry.

You go around to different mining schools around the world, there will be U of A alumni there, said Deutsch. In mining companies all over the world, there are always U of A alumni around there.

He also said the programs approach of being committed academically while remaining practical is what places the U of As mining education among the worlds best.

Even despite some economic woes in the province, we have essentially 100 per cent employment of our students graduating within six months of finishing, said Deutsch. We do that by remaining current and steadfast in our focus on solving real-world mining problems.

One of the enduring legacies of Kerry Mummery, outgoing dean of the Faculty of Kinesiology, Sport, and Recreation, will be the university ranked in the top 10 in the category of sport-related fields in each of the final four years of his tenure, up to seventh from ninth this year.

"During my tenure as dean, I've had the pleasure of working with and bringing in some of the top professors in their field," said Mummery. "I've always been impressed with the quality of their work and how that work makes its way into the classroom to provide our students with a solid foundation of knowledge they wouldn't have found anywhere else."

In the original rankings published in March, other U of A subjects that made the top 50 included nursing, which fought its way back into the top 20 to land at 18th; earth and marine sciences, which rose from 44th to tie for 41st; education, which rebounded from 47th to stick at 44th; and anatomy and physiology, which ranked 44th.

James Young, professor and chair of the U of As Department of Physiology, said he pins the U of As excellence in physiology to strategic recruitment pushes over the past four decades.

We've had sustained recruitment of really excellent young faculty members who want to be part of an excellent environment, and we offer that, said Young. They're not just joining the Department of Physiology, they're joining the faculty and becoming part of a number of research institutes and facilities that really are world class.

Overall, the U of A ranked in the top 100 in 17 subjects and 38 in the top 250. No ranked subject had the U of A lower than ninth nationally, and the university was ranked top five in Canada in 21 categories.

As for the five broad subject ranks, the U of A moved up seven spots to 90th in life sciences and medicine, while dipping slightly in engineering and technology (down to 112 from 107), natural sciences (111 to 116) and arts and humanities (137 to 143). Social sciences and management surged 12 spots to finish at 160.

The methodology for compiling each subject ranking can vary greatly and depends on the publishing rates in each area. Academic reputation, which accounts for anywhere from 30 to 90 per cent of the weight given in determining the rank in a subject area, draws on responses from thousands of academics worldwide.

Other measures include employer reputation, which makes up between 10 and 30 per cent of the measure; citations per paper, which also accounts for between 10 and 30 per cent; and h-indexa way of measuring both the productivity and impact of an academic's published workwhich is valued anywhere from 10 to 30 per cent.

The success in this latest QS ranking follows news in October that the U of A moved back into the top five in Maclean's 2020 Canadian University Rankings, thanks in part to strong showings by the faculties of nursing, business and science.

In August, the ShanghaiRanking Consultancys 2019 Academic Ranking of World Universities by Subject saw the U of A jump into an eighth-place tie with Princeton in the category of environmental science and engineering. Overall, the U of A finished among the top 100 in 21 of the 54 subjects assessed for the ranking, one more than the previous year, with eight subjects ranking in the top 50.

Earlier, the 2019 NTU Ranking of research output placed the U of A 81st in the world, up seven spots over the prior year. The advancement was bolstered by the university's 43rd-place performance in the subject of agricultural science, 47th in environment/ecology and 48th in electrical engineering.

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U of A ranked among world's top energy research universities - Folio - University of Alberta

Does Diet And Gut Bacteria Contribute To Arteries Aging? – Anti Aging News

Recent research from University of Colorado Boulder researchers published in the American Heart Association journal Hypertension suggests that a compound produced in the gut when we eat red meat damages our arteries, and it may play a role in boosting the risk of developing heart disease as we get older.

The report also suggests that an individual may be able to prevent or even reverse this age related decline by making some simple dietary changes and implementing targeted therapies such as nutritional supplements.

Our work shows for the first time that not only is this compound directly impairing artery function, it may also help explain the damage to the cardiovascular system that naturally occurs with age, said first author Vienna Brunt, a postdoctoral researcher in the Department of Integrative Physiology.

When a person eats a portion of steak or a plate of scrambled eggs the resident gut bacteria immediate set to work at breaking it down, as they metabolize the amino acids L-carnitine and choline they churn out trimethylamine metabolic byproducts which the liver then converts into trimethylamine-N-Oxide, known as TMAO, and sends it coursing through the bloodstream.

Studies have shown that those with higher blood levels of TMAO are more than twice as likely to experience a heart attack or stroke, and those with higher blood levels of TMAO also tend to die earlier. However, scientists dont fully understand why.

This team set out to answer three questions drawing on both animal and human experiments: Does TMAO somehow damage the vascular system? If it does damage the vascular system how? And is it one of the reasons why cardiovascular health declines, even among those who dont smoke and exercise as they get older?

Blood and arterial health of 101 older adults and 22 young adults were measured, which revealed that TMAO levels significantly increase with age. This finding supports a previous mouse study showing the gut microbiome changes with age, breeding more bacteria that help to produce TMAO. Adults with higher levels of TMAO were found to have significantly worse artery function and showed greater signs of oxidative stress or tissue damage in the lining of their blood vessels.

When TMAO was fed directly to young mice their blood vessels aged rapidly. Just putting it in their diet made them look like old mice, said Brunt. She noted that 12-month-old mice (the equivalent of humans about 35 years old) looked more like 27-month-old mice (age 80 in people) after eating TMAO for several months.

Preliminary data suggest that mice with higher levels of TMAO also exhibit decreases in learning and memory, indicating that it may play a role in age related cognitive decline.

Older mice that ate dimethyl butanol were observed to experience their vascular dysfunction reverse; the team believes that this compound may prevent the production of TMAO. Dimethyl butanol can be found in olive oil, vinegar, and red wine in trace amounts.

The team notes that even a young vegan will produce some TMAO, but over time consuming a lot of animal products may take a toll on vascular health. The more red meat you eat, the more you are feeding those bacteria that produce it, said Brunt.

According to senior author Doug Seals who is the director of the Integrative Physiology of Aging Laboratory this study is an important breakthrough as it sheds new light in why the arteries erode with age, even within the seemingly healthiest of people.

Aging is the single greatest risk factor for cardiovascular disease, primarily as a result of oxidative stress to our arteries, said Seals. But what causes oxidative stress to develop in our arteries as we age? That has been the big unknown. This study identifies what could be a very important driver.

The team is further exploring possible compounds that may block the production of TMAO to prevent age related vascular decline. Until something is found perhaps it may be a good idea to skip that big steak or at least limit the intake of animal products to incorporate more plant based options, as the gut friendly plant based diet can help to reduce levels of TMAO as well.

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Does Diet And Gut Bacteria Contribute To Arteries Aging? - Anti Aging News

A redox-active switch in fructosamine-3-kinases expands the regulatory repertoire of the protein kinase superfamily – Science

Kinase regulation conserved under stress

Oxidative stress is necessary for normal cellular function and tissue physiology but can also be pathological, and its effects are mediated in part through functional modification of various proteins. Shrestha et al. and Byrne et al. found that the oxidation of kinases at active siteadjacent cysteine residues, which were conserved across the eukaryotic kinome, regulated cell metabolism and mitosis. Shrestha et al. found that conserved cysteine residues within the diabetes-associated metabolic kinase FN3K acted as a toggle switch upon oxidation, promoting its functional oligomerization and consequently altering cellular redox status. Byrne et al. found that oxidation of mitotic kinases in human cells and yeast suppressed kinase catalytic activity and, in yeast, impaired cellular division. Exploring the effect of chronic oxidative stress on kinase function and how that may be spatiotemporally regulated may enable the development of new targeted therapeutics.

Aberrant regulation of metabolic kinases by altered redox homeostasis substantially contributes to aging and various diseases, such as diabetes. We found that the catalytic activity of a conserved family of fructosamine-3-kinases (FN3Ks), which are evolutionarily related to eukaryotic protein kinases, is regulated by redox-sensitive cysteine residues in the kinase domain. The crystal structure of the FN3K homolog from Arabidopsis thaliana revealed that it forms an unexpected strand-exchange dimer in which the ATP-binding P-loop and adjoining strands are swapped between two chains in the dimer. This dimeric configuration is characterized by strained interchain disulfide bonds that stabilize the P-loop in an extended conformation. Mutational analysis and solution studies confirmed that the strained disulfides function as redox switches to reversibly regulate the activity and dimerization of FN3K. Human FN3K, which contains an equivalent P-loop Cys, was also redox sensitive, whereas ancestral bacterial FN3K homologs, which lack a P-loop Cys, were not. Furthermore, CRISPR-mediated knockout of FN3K in human liver cancer cells altered the abundance of redox metabolites, including an increase in glutathione. We propose that redox regulation evolved in FN3K homologs in response to changing cellular redox conditions. Our findings provide insights into the origin and evolution of redox regulation in the protein kinase superfamily and may open new avenues for targeting human FN3K in diabetic complications.

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A redox-active switch in fructosamine-3-kinases expands the regulatory repertoire of the protein kinase superfamily - Science

Abnormal proteins in the gut linked to Alzheimers Disease – The Siasat Daily

Hong Kong:Misfolded protein build-up in the gut could contribute to the development of Alzheimers-like symptoms, researchers have shown.

This new finding, published in the Journal of Physiology, suggests a new treatment approach for Alzheimers disease that would target the gut before symptoms of cognitive deficits appear in patients.

As these proteins were found in the gut, this suggests environmental factors might be contributing to cognitive deficits seen in Alzheimers disease and other conditions, the researchers from the Chinese University of Hong Kong, wrote.

Beta-amyloid, the misfolded protein known to be involved in Alzheimers disease, was injected into the guts of mice and travelled to the gut-brain (the nervous system in the gut), and also to the brain.

The proteins moved to the nervous system in the gut.

The misfolded proteins were seen a year later in parts of the brain involved in cognitive deficits of Alzheimers disease including the hippocampus, the part of the brain that affects the memory.

According to the researchers, these animals experienced cognitive impairment.

As this study was conducted in mice, it needs verification by looking for post-mortem changes in inflammation in the gut and brain of patients with Alzheimers disease, the research team noted.

This concept is similar to the transport of misfolded proteins from the gut such as those responsible for mad cow disease, said study senior author John A. Rudd.

If this is the case, a similar process may start in humans many years ahead of the manifestations of the classical hallmarks of AD including memory loss, and so prevention strategies would need to start earlier as well, he added.

Development of drug treatments for Alzheimers disease has been unsuccessful so we instead need new approaches for preventing AD development, the study authors wrote. This could be a potential route for preventing the disease by targeting these misfolded proteins in the gut, they noted.

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Abnormal proteins in the gut linked to Alzheimers Disease - The Siasat Daily