Category Archives: Physiology

Overview Of Biostimulants Industry 2020-2026:

This has brought along several changes in This report also covers the impact of COVID-19 on the global market.

The Biostimulants Market analysis summary by Reports Insights is a thorough study of the current trends leading to this vertical trend in various regions. Research summarizes important details related to market share, market size, applications, statistics and sales. In addition, this study emphasizes thorough competition analysis on market prospects, especially growth strategies that market experts claim.

Agricultural biostimulants include diverse formulations of compounds, substances and other products that are applied to plants or soils to regulate and enhance the crops physiological processes, thus making them more efficient. Biostimulants act on plant physiology through different pathways than nutrients to improve crop vigour, yields, quality and post-harvest shelf life/conservation.

Biostimulants Market competition by top manufacturers as follow: , Agri Life, Biostadt, Neophyll, Nakoda Biocontrols, Biotech International, India FarmCare, Miracle Organics Private, HCM Agro produts, Vijay Agro Industries, Arysta Life Science, VALAGRO, Leili, Acadian Seaplants, Kelpak, Grow More

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The global Biostimulants market has been segmented on the basis of technology, product type, application, distribution channel, end-user, and industry vertical, along with the geography, delivering valuable insights.

The Type Coverage in the Market are: Acid-based BiostimulantsExtract-based Biostimulants

Market Segment by Applications, covers:Fruits & VegetablesTurf & OrnamentalsRow Crops

Market segment by Regions/Countries, this report coversNorth AmericaEuropeChinaRest of Asia PacificCentral & South AmericaMiddle East & Africa

Major factors covered in the report:

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COVID-19 Effect On Biostimulants Market Share and Development 2020 - Cole of Duty

Physiology

Swedish Healthcare Region to Realize Integrated Diagnostics – Expands IT Solution From Sectra With Digital Pathology – BioSpace

June 29, 2020 medical

LINKPING, Sweden, June 29, 2020 /PRNewswire/ -- International medical imaging IT and cybersecurity company Sectra (STO: SECT B) has signed a digital pathology contract with Region Vstmanland in Sweden. The healthcare region already uses Sectra's software for handling medical images, which will now be expanded to also include digital pathology as it digitizes its pathology department. Using the same system to store and view images and information from various diagnostic specialties enables integrated diagnostics, which is key for efficient cancer care.

"We are excited to take the next step in our digitization journey toward a truly integrated diagnostic workflow. It is important that we can scale our solution at our own pace and Sectra's solution allows this. We are also looking forward to equipping our pathologists with the tools that support us in our efforts to provide the best possible cancer care," says Jonas Cederberg, Chair of Department for Medical Diagnostics at Region Vstmanland.

With digital images of tissue samples rather than physical glass slides, pathologists can instantly access and share current and historical images and information from anywhere and at any time. Digital pathology provides pathologists with tools that are not available when using a microscope, which reduces variation between examinations and enables pathologists to spend their time on more advanced tasks. The digital solution also provides pathologists with assistance at critical decision points, such as grading or performing more precise measurements. Furthermore, digital access facilitates second opinions, external reading resources, and specialist consultations.

Sectra's digital pathology solution will be integrated with Region Vstmanland's laboratory information system (LIS). This will provide pathologists with a complete overview of the patient history in one application and enable workflow orchestration to drive the workflow according to sub-specialties, rules and priorities. The solution's vendor-neutral approach also gave Region Vstmanland the freedom to select the scanner vendor of its choice.

Region Vstmanland is already using Sectra's solution for handling medical images within radiology, mammography, and clinical physiology. The solution will now also include approximately 10,000 pathology examinations per year, with the opportunity to gradually increase usage. The agreement to expand the existing contract was signed in May 2020.

Sectra's enterprise imaging solution provides a unified strategy for all imaging needs while lowering operational costs. The scalable and modular solution, with a VNA at its core, allows healthcare providers to grow from ology to ology and from enterprise to enterprise. Read more about Sectra's enterprise imaging solution and why Sectra PACS is ranked "Best in KLAS" for seven consecutive years at https://medical.sectra.com/.

About SectraSectra assists hospitals throughout the world to enhance the efficiency of care, and authorities and defense forces in Europe to protect society's most sensitive information. Thereby, Sectra contributes to a healthier and safer society. The company was founded in 1978, has its head office in Linkping, Sweden, with direct sales in 19 countries, and operates through partners worldwide. Sales in the 2019/2020 fiscal year totaled SEK 1,661 million. The Sectra share is quoted on the Nasdaq Stockholm exchange. For more information, visit https://sectra.com/.

CONTACT:

For further information, please contact:Dr. Torbjrn KronanderCEO and President Sectra AB+46-(0)705-23-52-27

Marie Ekstrm TrgrdhExecutive Vice President Sectra AB and President Sectra Imaging IT Solutions+46-(0)708-23-56-10

This information was brought to you by Cision http://news.cision.com

https://news.cision.com/sectra/r/swedish-healthcare-region-to-realize-integrated-diagnostics-expands-it-solution-from-sectra-with-dig,c3142885

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SOURCE Sectra

Company Codes: Stockholm:SECTB, ISIN:SE0012853661, RICS:SECTB.ST, LSE:0A0L, Stuttgart:ECRH

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Swedish Healthcare Region to Realize Integrated Diagnostics - Expands IT Solution From Sectra With Digital Pathology - BioSpace

Physiology

Wayne Medicine and Wayne Law professors team up to explore legal and ethical issues of wastewater monitoring for COVID-19 – The South End

June 27, 2020 medical

Faculty from the Wayne State University School of Medicine and Wayne State University Law School have teamed to publish a paper this month on legal and ethical issues associated with community detection of COVID-19 through wastewatermonitoring.

Professor of Physiology Jeffrey Ram, Ph.D., and Associate Professor of Law Lance Gable, Ph.D., along with Dr. Rams daughter, University of Maryland Professor of Law Natalie Ram, co-wrote Legal and Ethical Implications of Wastewater SARS-CoV-2 Monitoring for COVID-19 Surveillance, now available in the Journal for Law and Biosciences.

The paper, already a popular download, is listed on the Social Science Research Networks Top Ten download list in several categories.

Dr. Ram also is director of the Wayne State University Belle Isle Aquarium Field Research Laboratory.

Scientists have observed that molecular markers for COVID-19 can be detected in wastewater during an outbreak and, in some cases, before the first case is confirmed, they wrote. The U.S. Centers for Disease Control and Prevention, and other government entities, are considering whether to add community surveillance through wastewater monitoring to assist in tracking disease prevalence and guiding public health responses to the pandemic.

This scientific breakthrough may lead to many useful potential applications for tracking disease, intensifying testing, initiating social distancing or quarantines, and even lifting restrictions once a cessation of infection is detected and confirmed. Yet, new technologies developed in response to a public health crisis may raise difficult legal and ethical questions about how such technologies may impact both the public health and civil liberties of the population, the authors wrote. Even if reliability and efficacy are established, limits on sample and data collection, use and sharing, must also be considered to prevent undermining privacy and autonomy in order to implement these public health strategies consistent with legal and ethical considerations.

The article describes recent scientific evidence regarding COVID-19 detection in wastewater, identifying public health benefits that may result from this breakthrough, and limitations of existing data. It also assesses the legal and ethical implications of implementing policy based on positive sewage signals.

The topic of wastewater epidemiology of COVID-19 is a very new and extremely active one, Dr. Ram said. We (at Wayne State) have assembled a team that includes microbiologists, an epidemiologist, a law professor, medical students, collaborators outside of Wayne State and more.We have support from Healthy Urban Waters.

Healthy Urban Waters is a collaboration of WSU researchers networked with the community to focus on water in an urban setting and future impacts of human culture on community, the ecosystem and economic health.

Dr. Ram and Dr. Gable were invited to present at a new community interaction forum organized with COVID-313 by the WSU Office of theProvosts Social and Behavioral Determinants of Health Steering Committee. They plan additional projects together.

Natalie Ram writes about the legal and ethical uses surrounding various biotechnologies, including the use of DNA by the police. Her decision to pursue the philosophical side of science, including ethics and law, was partly inspired by her Wayne State connections.She was part of a summer science program for girls organized by Wayne State Professor Alvin Saperstein at Wayne State, and while a college student at Princeton she conducted molecular research one summer on pre-implantation genetic diagnosis at WSUs Center for Molecular Medicine and Genetics.

Physiology

Weekend events to mark 90th birthday of Nobel laureate William C Campbell – The Irish Times

June 27, 2020 medical

For Prof William C Campbell, Irelands only winner of the Nobel Prize in physiology or medicine, Sunday will mark another significant milestone in his remarkable life of scientific endeavour.

His 90th birthday will be celebrated at a small family gathering in Boston, but it will also coincide with publication by the Royal Irish Academy (RIA) of his memoir Catching the Worm a story of the discovery of the drug ivermectin for veterinary use in livestock to eliminate parasites, and then its subsequent adaptation for use in humans.

In 1987, nine years after the latter discovery, his employer Merck Research Laboratories decided to distribute the drug free of charge, saving millions of lives in the developing world in the process. As a result, the World Health Organisation moved from treatment to elimination of River Blindness which afflicted much of Sub-Saharan Africa.

Prof Campbell, who is from Ramelton, Co Donegal, won Nobel Prize with others in 2015 when aged 85 and well into an enjoyable retirement.

His early education was in the converted attic of his home. His father, a local shopkeeper, employed a live-in tutor. He later attended Campbell College near Belfast and studied natural sciences at Trinity College.

The town had planned to unveil a life-size bronze statue of him by sculptor Paul Ferriter this weekend but this had to be postponed due to Covid-19. A local committee has decided instead to send him a virtual birthday present, according to Jean Winston who is helping to compile the digital gift.

It will include music and song; a poem by Denise Blake, a birthday card created by artist Laura Buchanan and a message from Minister for Education Joe McHugh, a fellow Donegal manwho has described the parasitologist as one of the most inspirational people on the planet, who has arguably done more for humanity than any other Irish person.

On Sunday evening, the RIA and the RDS will present Catching the Worm a filmed podcast William C Campbell in conversation with Prof Luke ONeill of Trinity College and Dr Claire OConnell who wrote the book with the Nobel laureate at 8pm via ria.ie/catchingtheworm

Prof Campbell said he was sorry he could not be in Ireland as planned but that he would be having a wonderful time of togetherness with his family.

In the podcast, he makes a strong plea for risk-taking and empirical research, especially in the search for new drugs, rather than the current scenario of using molecular biology to design medications.

There should be a place for chance discovery, he added, and advised young scientists to retain curiosity, exploration and a sense of adventure during their careers. Being first to do something, that is perfectly valid, he added.

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Weekend events to mark 90th birthday of Nobel laureate William C Campbell - The Irish Times

Physiology

Global Consumer mHealth Market Report with forecast upto Including the Impact of Covid: Vodafone, Apple, NTT Docomo, Samsung Electronics, AT&T…

June 27, 2020 medical

Consumer mHealth (mobile health) is the practice of medicine and consumer health by using mobile devices. The consumer mHealth uses mobile and wireless technologies to generate data on an individuals biology, daily environment and physiology. mHealth aids in the fast delivery of telemedicine services by using 4G & 3G LTE networks enabled services such as high-speed data transfer and video calling. Mobile health technologies consists of one-way and two-way data applications. One-way data application comprises the flow of information from physician or healthcare practitioner to patients by educative methodology & SMS. The two-way model rely on data access programs, such as remote monitoring and client record access. The consumer mHealth market is expected to witness lucrative growth with healthy CAGR during the forecast period.

The drivers of consumer mHealth market are advancements in medical technologies or increase in adoption of smartphones, increase in income levels, change in consumer preferences due to rising adoption for data services, healthy government policies, and significant regulatory scrutiny. Furthermore, increase in physicians acceptance, increasing the prevalence of diseases due to rising aging population and changing lifestyle, and increasing incidences of chronic diseases (diabetes, heart ailments & cancer).

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Consumer mHealth Market Segmentation:

Top leading Manufactures Profiled in Consumer mHealth Market Report are:

Vodafone, Apple, NTT Docomo, Samsung Electronics, AT&T Services, Healthdirect, MQure Health, Allscripts Healthcare Solutions, Qualcomm

Market Research Study Focus on these Types:

Blood Glucose MetersBlood Pressure MonitorsNeurological Monitoring DevicesECG MonitorsOthers

Market Research Study Focus on these Applications:

AdultsTeenagersChildren

The report highlights major developments and changing trends adopted by key companies over a period of time. For a stronger and more stable business outlook, the report on the global market carries key projections that can be practically studied.

Consumer mHealth Market analysis report has recently added by Research which helps to make informed business decisions. This research report further identifies the market segmentation along with their sub-types. The Consumer mHealth Market is expected to reach at a huge CAGR during the forecast period. Various factors are responsible for the markets growth, which are studied in detail in this research report.

Browse the Full report description and TOC at:

https://www.marketinsightsreports.com/reports/07151359924/global-consumer-mhealth-market-size-status-and-forecast-2019-2025?Mode=21

Consumer mHealth Market Scenario:

This research report represents a 360-degree overview of the competitive landscape of the Consumer mHealth Market. Furthermore, it offers massive data relating to recent trends, technological advancements, tools, and methodologies. The research report analyzes the Consumer mHealth Market in a detailed and concise manner for better insights into the businesses.

Report evaluates the growth rate and the Market value based on Market dynamics, growth inducing factors. The complete knowledge is based on latest industry news, opportunities and trends. The report contains a comprehensive Market analysis and vendor landscape in addition to a SWOT analysis of the key vendors.

The key insights of the Consumer mHealth Market report:

The report provides key statistics on the market status of the Consumer mHealth market manufacturers and is a valuable source of guidance and direction for companies and individuals interested in the industry.

The report provides a basic overview of the industry including its definition, applications and manufacturing technology.

The Consumer mHealth market report presents the company profile, product specifications, capacity, production value, and 2014-2020 market shares for key vendors.

The total market is further divided by company, by country, and by application/type for the competitive landscape analysis.

The report estimates 2020-2026 market development trends of Consumer mHealth Market.

Analysis of upstream raw materials, downstream demand and current market dynamics is also carried out

The report makes some important proposals for a new project of Consumer mHealth Industry before evaluating its feasibility.

In conclusion, Consumer mHealth market report presents the descriptive analysis of the parent market supported elite players, present, past and artistic movement information which is able to function a profitable guide for all the Consumer mHealth Industry business competitors. Our expert research analysts team has been trained to provide in-depth market research report from every individual sector which will be helpful to understand the industry data in the most precise way.

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Global Consumer mHealth Market Report with forecast upto Including the Impact of Covid: Vodafone, Apple, NTT Docomo, Samsung Electronics, AT&T...

Physiology

WHOOP Goes The PGA Tour – SCOREGolf

June 27, 2020 medical

The five-time PGA Tour winner negative upon his arrival at the golf course tested positive following his opening round 74 at Hilton Head. He withdrew, then immediately went into quarantine as mandated by the tours coronavirus health and safety protocol.

Watney will do so until next week. Once out of isolation he requires two negative tests to return to the golf course.

Ive been wearing a Whoop strap for more than a year now and Ive learned to read and understand the data, Watney said. On Friday morning of the RBC Heritage I saw my respiratory rate had spiked on Thursday night. This was consistent with information shared by the Whoop community, that is could be an early indication of Covid-19. This alerted me to ask the PGA Tour for a test even though I didnt have any other symptoms, and I unfortunately tested positive. Im very grateful to have identified these signs early enough and I am now following PGA Tour protocol.

Misery, as they say, tends to love company. It comes as no surprise that Watney no longer is a single on the quarantine sidelines. Cameron Champ and tour caddies Ken Comboy and Ricky Elliott, regular loopers for Graeme McDowell and Brooks Koepka respectively, tested positive this week. Both players withdrew from the Travelers as a precaution, as did Webb Simpson. The RBC Heritage champion WDd upon learning of a positive test within his family.

And Friday the hits kept coming. Denny McCarthy became the latest casualty. The 2018 Web.com Tour Championship winner tested positive prior to his second round at Travelers. One of his playing partners, Bud Cauley, withdrew out of precaution, while the other, Matt Wallace, played as a single Friday.

Before leaving Wednesday on a 17-hour sojourn home to Orlando by car (to avoid air travel), McDowells assessment of the virus at the Travelers was short but telling.

The snowball is getting a little bit bigger, he told the Associated Press.

Something similar could be said about Whoop. An unintended beneficiary of circumstance, exposure of the brand during the past week has grown to an unprecedented level.

Multiple positive tests, coupled with validation by endorsers/users like Rory McIlroy, Justin Thomas and Scott Stallings, prompted the PGA Tour to align with Whoop. An order for 1,000 of the fitness bands was placed with the Boston, Mass.-headquartered company and delivered Wednesday at the Travelers.Korn Ferry Tour and PGA Tour Champions players, plus caddies and essential staff on those circuits, will also be sent the Whoop strap. No details of the arrangement were announced. Whoop users must pay a monthly membership fee to utilize the bands technology.

We are rapidly onboarding everyone in the PGA Tour universe as of yesterday and respect the measures that they are taking to keep the tour safe, Will Ahmed, company founder and chief executive, posted on Twitter Wednesday.

Waiting in prospect is the possibility of an extended reach into other professional sports. Watneys positive test is certainly quite a sales pitch. And with the NBA, NHL, MLB and other major professional sports organizations continuing to monitor the PGA Tours return to work as they prepare to do the same next month Whoop technology applications are bound to be considered.

We believe that the data were collecting on athletes is unprecedented, both in its sophistication and scale, said Ahmed in a company generated release. No physiological studies have ever occurred on this magnitude. Whoop benefits from the fact athletes also have tangible performance data (wins/losses, batting average, time trials, etc.) across sports. We want to share this data. There is an unbelievable correlation between physiology and performance; the approach to health monitoring and the different ways to interpret or action your bodys feedback.

Stallings brought Whoop to my attention during a conversation at last years RBC Canadian Open at Hamilton G&CC.

I was complimenting the three-time tour winner on his weight loss turns out it was 50 pounds when the longtime Titleist brand ambassador explained the devices role in helping him in his quest for better health.

The technology, man, its crazy, he said. It keeps me on track. But it also has all kinds of health and fitness data on how Im sleeping, training, recovering from workouts, my peak performance efficiencies. Its made me accountable. I love it.

Not in the field at the Travelers, Adam Hadwin has yet to receive his band. The 2017 Valspar champion is still getting up to speed on the Whoop technology and its capabilities but he was quick to credit the tour for the initiative.

If there is even a chance it could help, it makes sense that the tour has stepped up and is trying to protect its players, he said in a note. I cant speak to the legitimacy of the claims, but with us travelling constantly, city-to-city, its worth using anything that may help show exposure.

Hadwin is right. Having Whoop on board the PGA Tours road show wont stop positive tests for coronavirus from happening. What the health and wellness fitness band can do is help keep it from spreading.

Read the rest here:
WHOOP Goes The PGA Tour - SCOREGolf

Physiology

Elixir Medical Announces Outstanding 12-Month Data for DynamX Coronary Bioadaptor System, Demonstrating No Target Vessel Revascularization, No…

June 25, 2020 medical

PARIS--(BUSINESS WIRE)-- Elixir Medical, a developer of innovative, drug-eluting cardiovascular devices, today announced outstanding 12-month data for the DynamX Coronary Bioadaptor System, the first coronary artery implant that adapts to vessel physiology. Results will be presented live tomorrow at 14:12 CEST on the Main Arena channel of the PCR e-Course as part of the Late Breaking Trials session by Stefan Verheye, MD, PhD, co-principal investigator and senior interventional cardiologist at the Antwerp Cardiovascular Centre/ZNA Middleheim, Belgium.

Twelve-month results for the DynamX Bioadaptor demonstrate:

Coronary arteries naturally have the ability to expand with disease progression in order to maintain blood flow to the heart, said Antonio Colombo, MD, co-principal investigator and director, Cardiac Catheterization Laboratory, Columbus Hospital, Milan and Coordinators Cardiac Catheterization Laboratories GVM Group, Care and Research, Lugo (RA), Italy. Drug-eluting stents (DES) cage the coronary arteries and hinder this physiological response. DynamX is the first metallic coronary artery implant to demonstrate positive adaptive remodeling of the vessel, enabling it to expand to accommodate disease progression. This may improve longer-term clinical outcomes.

The innovative DynamX Bioadaptor design was shown to match current drug-eluting stents (DES) in acute performance while offering the promise to improve upon the high adverse event rates that continue beyond year one with DES, said Dr. Verheye. In all measures, including clinical, QCA, IVUS, OCT, the bioadaptor demonstrated excellent performance and safety.

The DynamX Bioadaptor is the only metallic drug-eluting coronary artery device designed to open and support the artery during healing, like a stent, while uniquely accommodating the vessels ability to grow in response to disease progression, which current DES cannot do.

The bioadaptor is designed to address the two to three percent adverse event rate that occurs with drug-eluting stents (DES) each year without plateau.1,2,3 The rigid design of DES constrains, or cages, natural artery movement, which has been associated with major adverse cardiac events (MACE).4 Clinical studies have shown that DES prevents positive adaptive remodeling,5 inhibits vessel compliance and dilation in response to the bodys changing blood flow needs,6,7 and causes vessel straightening.8

While DES do an efficient job supporting the coronary artery, they permanently cage the vessel and show an adverse event rate that continues to build year-over-year without end. Physicians and their patients deserve a technology that treats coronary artery disease without making this compromise, said Elixir Medical CEO Motasim Sirhan. Elixirs DynamX Bioadaptor stands as the only technology that has solved this conundrum. By creating a coronary artery device that restores the normal function of the artery, we expect to demonstrate safety and efficacy with a reduction in clinical events.

The multi-center, single-arm, mechanistic clinical study enrolled 50 patients treated at six centers in Europe to evaluate the safety and performance of the device in de novo native coronary arteries. Primary endpoints included Target Lesion Failure (TLF), as well as QCA, IVUS and OCT measures.

The DynamX Bioadaptor is a metal implant coated in a drug-eluting bioresorbable polymer that initially supports the coronary artery during healing with radial strength, similar to DES. Over six months, the polymer coating dissolves, freeing couplers or uncaging elements on the rings to move with the natural expansion and contraction of the artery. This has been shown to (a) maintain the ability for positive adaptive remodeling, (b) restore vessel function, and (c) allow for the vessels return towards baseline angulation.

Prof. Verheyes presentation will also be available on-demand following the Late Breaking Trial session at PCR Online.

About Elixir Medical

Elixir Medical Corporation, a privately-funded company based in Milpitas, California, develops next-generation systems to treat coronary artery disease that are designed to restore the normal pulsatile motion and adaptive remodeling capabilities of the blood vessel. The companys mission is to transform the care of patients with heart and vascular disease through innovation.

DynamX Coronary Bioadaptor System is CE Mark approved. Not available for sale in the USA.

View source version on businesswire.com: https://www.businesswire.com/news/home/20200625005169/en/

Physiology

Affluent Medical Announces the Launch of the MINERVA First-In-Human Clinical Study of EPYGON – BioSpace

June 25, 2020 medical

AIX-EN-PROVENCE, France--(BUSINESS WIRE)-- Affluent Medical is a French MedTech company specialized in innovative, minimally-invasive implants designed to restore key physiological functions in patients suffering from structural heart diseases, as well as urinary incontinence. The company announces today the start of the MINERVA First-In-Human clinical study of EPYGON, the first physiological transcatheter mitral valve prosthesis.

Professor Martin Andreas, Principal Investigator of this First-In-Human study at the Vienna Medical University, stated:The left ventricle vortex is a physiological process which is abolished after standard surgical mitral valve replacement. It is well known that survival is decreased after mitral valve replacement compared to mitral valve repair, which protects the vortex. Therefore, this feature of the EPYGON valve has the potential to improve patient outcomes. We hope to observe this unique advantage of the EPYGON transcatheter valve in our patients with respect to all other valve replacement technologies, whether via transcatheter or open surgery.

Michel Finance, CEO of AFFLUENT MEDICAL, said:The start of the MINERVA pilot trial is a major step forward for Affluent Medical. EPYGON is a world premiere and a potential best-in-class valve in a market where physiology has been overlooked for decades. This pilot study aims to confirm the improved clinical outcomes already demonstrated in preclinical testing. It should open up a new era both for surgeons and patients, with physiology as a key factor in cardiac surgery. EPYGON is unique, notably as it mimics the physiological human valve.

The MINERVA study: First-In-Man Clinical Study for the Treatment of Severe Mitral Valve INsufficiency with the EPYGON TRanscatheter Mitral VAlve System.

MINERVA is a pilot, prospective, non-randomized, single-arm, multicentric and international study. It is designed to enroll up to 20 patients in 3 centers of 3 different European countries (Austria, Italy and Spain). Patient enrollment is planned to be completed by Q1 2021 and the primary endpoints results will be evaluated after one year of follow-up .

EPYGON, a breakthrough mitral technology designed to treat both left ventricle disease and mitral regurgitation at the same time

Today, 4 million patients across the United States, Europe and Asia suffer from severe mitral valve regurgitation with no access to optimal therapies.

EPYGON is the first transcatheter mitral valve designed to restore the physiological blood flow vortex and treat left ventricle disease, in particular in so-called functional patients.

No mitral valve prosthesis currently on the market or in development was designed to restore the vortex.

The unique concept and design of the EPYGON valve is expected to achieve high procedural success, restore left ventricle physiological flow, and offer excellent performance in terms of the absence of thrombus formation and LVOT obstruction, while eventually also alleviating left ventricular effort.

The safety and efficacy of EPYGON were tested in preclinical models and the CE marking pivotal trial is slated to begin at the beginning of 2022, for planned introduction on a global market currently growing at a rate of 35% per year and expected to reach $3.5 to 5.0 billion by the end of 2022.

About Affluent Medical

Affluent Medical is a French MedTech company founded by Truffle Capital with the ambition to become a European leader in the treatment of heart and vascular diseases, which are the worlds leading cause of death, and of urinary incontinence, which today affects one in four adults. Affluent Medical develops innovative, next-generation minimally-invasive implants to restore key physiological functions in these areas. The companys four major technologies are currently in preclinical and clinical phases, and a first medical device is expected to be launched by 2022.

For more information: http://www.affluentmedical.com

About the PSPC MIVANA project :

The PSPC MIVANA project was built to create a cluster for innovative implantable medical devices targeting the mitral valve. This innovative collaborative project is led by Affluent Medical (EPYGON and Kephalios), a pioneering start-up and leader in the growing market segment of implantable cardiac devices. The project also includes two other partners: MDB Texinov, a SME specialized in technical textiles that is involved in the design and automation of assembly processes and the industrialization of new products. The French Textile and Clothing Institute (IFTH) involved in the selection of textile materials / structures and the design of prototypes.

The project aims to develop two proprietary cardiovascular Implantable Medical Devices (IMDs) to treat mitral valve diseases at different stages through repair or replacement. This R&D project, accompanied and labeled by the Eurobiomed (Marseille, Montpellier ple porter), Techtera (Lyon) and Medicen (Paris) competitiveness clusters, has won the PSPC (Structuring Projects for Competitiveness) call for projects of Bpifrance Financement. The MIVANA consortium is investing nearly 30 million, and is funded for up to 8.6 million.

1 See press release dated June 24, 2020 Affluent Medical announces 15.8 million in new financing and strengthening of its board of directors.

View source version on businesswire.com: https://www.businesswire.com/news/home/20200624005498/en/

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Affluent Medical Announces the Launch of the MINERVA First-In-Human Clinical Study of EPYGON - BioSpace

Physiology

10 Reasons Why Wonder Man Is Actually The Most Powerful Avenger – CBR – Comic Book Resources

June 25, 2020 medical

When it comes to the Most Underrated Avengers Awards, Wonder Man (Simon Williams) is definitely up for a nomination. Like many other superheroes who don't look peculiar or sexy enough or lack a cape, Wonder Man is overshadowed by the big and popular heavy hitters and charisma machines.

RELATED:10 Things Marvel Fans Should Know About Brother Voodoo

Still, one cannot ignore hard facts about Wonder Man's powers and contributions to the Avengers in the comic books. Apart from being one of the most zealous and dedicated members of the collective, he's also got the capabilities to back it up. In fact, Wonder Man can be just as powerful as the more established heroes of Marvel like Thor or even the Hulk. Here's proof in case fans don't find him wonderful enough.

Move over Spider-Man, here's a superhero who can actually handle one of your worst nightmares. The alien Symtiotes of Marvel like Venom or Carnage has long plagued the comic books thanks to how easily they can assimilate large swathes of populations, including superheroes.

Since Wonder Man no longer abides by the rules of human physiology or even biological physiology thanks to his ionic form, he's pretty much immune to the alien Symbiote invasion. It does come with a cost-- since he's not exactly flesh and blood, he can no longer sire any children. Fair trade.

This is where it gets debatable. Apparently, Wonder Man is placed in the 100-ton strength class of Marvel. Who else is up there? Only the Hulk, Sentry, and Thor to name a handful few good guys. That very well means Wonder Man is on the same ballpark as Marvel's Superman-level heroes.

The upper limits of Wonder Man's strength are still unknown but he seems to remain coy and humble about it. At times, he even claims that while he's in the same class with Thor, he acknowledged that the Asgardian is still stronger.

Wonder Man's strength alone would be enough to give him an all-access pass in the Avengers. However, he goes well above and beyond the qualifications. Wonder Man is also super-fast, has super reflexes, flight, super durability, super agility, super stamina, super senses, invulnerability, immortality, and regenerative healing.

Oh, we're not done. He can also manipulate and weaponize energy, creating devastating beams from his hands and eyes (not that he would need them). On top of that, Simon Williams has genius-level intellect. It's like Marvel is fighting hard for him not to be underrated.

That one Hulk weakness where he has limitless strength but behaves like a raging infant? Wonder Man doesn't have it. Wonder Man is consciously powerful and is also a martial arts expert.

He trained under Captain America for this and he's one of the best hand-to-hand combatants in the Avengers. This gives Wonder Man afighting edge against similarly strong supervillains or superheroes.

Since Wonder Man is not exactly human anymore by physiological standards, he doesn't actually have to assume a human form. He only does so because that's his past. Wonder Man can choose any form, size, or shape that he wants.

It's just that he doesn't really find a need to do this often or isn't usually given a chance in the comic books. Wonder Man can consciously shapeshift into any being-- his imagination being the limit; he eventransformed into a demon at one point. It also means he can opt to change his appearance or costume anytime but choose to abide by his fashion sense.

The claim that Wonder Man is a complete package of a superhero is super serious. Another role he could easily fill in the Avengers would be espionage, especially with SHIELD or Nick Fury around.

RELATED:The Boys: 5 Heroes Homelander Can Defeat (& 5 He Cant)

That's because Simon Williams is also a famous actor and even earned his spot in the Hollywood Walk of Fame. He can easily be a good undercover agent like Blackwidow or Spider-Woman. Couple that with shapeshifting and who even needs those two?

As if being a complete package isn't enough already, Wonder Man, in his latest incarnations and resurrections, is also capable of defying the laws of space. He can teleport or warp unknown distances.

This easily makes him more useful compared to similarly-powered superheroes. Wonder Man is already a jack-of-all-trades but also a master of it all. Well, not quite for teleportation as he's still developing and learning how to grasp those powers but he can already do it at will.

With all those powers, one would think that he'd have a massive glaring weakness like Sentry's mental health, the Hulk's lack of control, or Thor's intelligence level. Wonder Man doesn't have any of those psychological instabilities apart from a few nervous breakdowns.

RELATED:5 Wonder Man Costumes We Loved (& 5 Everyone Hated)

Instead, his main weakness is that he's easily disrupted with energy weaponry which is an exception against his invulnerability. Any weapon that can disperse energy or is specifically made to work against ionic matter is dangerous to Wonder Man.

Turns out Wonder Man's main weakness got the best of him many times over the course of his Avenger career. He has died several times over but because he doesn't exactly function as a biological being, he just toys with the concept of death plenty of times.

At one point, Kang the Conqueror even disintegrated him but Wonder Man was able to reform himself-- albeit slowly. In total, Wonder Man has died around six times in Marvel, the first of which even happened during his first appearance. What's surprising about some of his deaths was his ability to resurrect independently.

Just like a certain messiah born in Bethlehem, Wonder Man only gets more powerful every time he dies and gets resurrected. In many of his deaths, the superhero essentially Jesus'd his way into being overpowered.

As he reforms or is reformed by other beings like the Scarlet Witch, Wonder Man keeps discovering new powers with every rebirth. No doubt he'll always be a heavy hitter pick for the Avengers due to his positive power curve. All that's left to wonder about Wonder Man is when he'll debut in the MCU? After all, he was a romantic interest of both Scarlet Witch and Captain Marvel.

NEXT:MCU: 10 Ways Wonder Man Could Join The Fray

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10 Reasons Why Wonder Man Is Actually The Most Powerful Avenger - CBR - Comic Book Resources

Physiology

Harnessing complexity to advance epilepsy research: Learning the language of EEG spike-wave discharges – Newswise

June 25, 2020 medical

Newswise Jesse A. Pfammatter was awarded the Epilepsia Open Prize 2020 Basic Science Prize for the articleAn automated, machine learning-based detection algorithm for spike-wave discharges (SWDs) in a mouse model of absence epilepsy.

Clinical spike-wave discharges (SWDs) are EEG patterns seen particularly during absence seizures, a nonconvulsive type of seizure. Though they were first identified more than 100 years ago, many aspects of SWDs are still being discovered.

Despite the time and effort, the standard of practice both clinically and in research is to manually identify SWDs, versus using software. Jesse Pfammatter, a post-doc in Mathew V. Jones lab at the University of Wisconsin, didn't subscribe to this standard for a couple of reasons. First, Pfammatter hadnt been an epilepsy researcher for very long. Second, he was self-professedly terrible at manual identification.

Pfammatter also had noticed that others weren't terrifically skilled at it either; in fact, identifying SWDs seemed quite subjective. Every human is different in their scoring of these, said Pfammatter. Not only is their scoring different from other humans scoring, but people change their minds about a discharge depending on its context. If its near other events, people tend to mark it as epileptiform, whereas if its by itself, they dont.

Pfammatter and colleagues also found that expert human scorers could change their minds about a specific EEG waveform upon repeated viewing. Sometimes, a single expert would disagree with themselves quite often, depending on what waveform they were looking at, said Jones. This suggests that human scoring of EEG waveforms is not entirely reliable.

Theres useful information in variability

Rather than give in to the idea that SWDs are merely difficult to categorize, Pfammatter saw the complexity as potentially useful. We put a lot of things in categories that dont necessarily fit in categories, he said. What if the subjective nature of the discharges could be harnessed?

Pfammatter and colleagues developed an automated detection algorithm that uses machine learning to highlight the variability in SWDs, rather than ignore it. The software uses a probabilistic scale, not a categorical scale, explained Pfammatter. Our research assumes theres useful information in variability.

The algorithms probability scores correlated with the variability seen in human scoring. The group also found that higher-probability events more strongly related to the physiology of the mice, particularly in terms of sleep-wake transitions, which are associated with many epilepsies.

Next, the group plans to apply the algorithm to experimental situations in which SWD variability provides information about physiology. For example, said Pfammatter, We know that treatments are effective across a spectrumits isnt just yes, they stop seizures or no, they dont. Were hoping we can test some of these signals to see if they change in the presence of certain therapeutics. That could give us insight into how treatments are working. And maybe we can start to understand why a medication works in one animal but not in another.

The lab also works with models of post-traumatic epilepsy. After a trauma, theres some probability that someone will develop epilepsy, in some unknown amount of time, Pfammatter said. Were finding subtle EEG markers that might indicate which individuals might go on to develop epilepsy. Its a higher-resolution understanding.

From entomology to epilepsy

Back to that first point, that Pfammatter hasnt been an epilepsy researcher for very long. Pfammatter grew up in a northern suburb of Chicago and earned a PhD in entomology at the University of Wisconsin. He studied bark beetle ecology and took extensive graduate coursework in statistics and biometrics.

Toward the end of his graduate career, he met Jones, associate professor of neurology, at a bar frequented by graduate students and faculty members. The two began talking and learning about one anothers research. Though they were studying different topics, both were immersed in multivariate data. His research was really interesting to me, Pfammatter said. There are similarities between community ecology and neuroscience, and the statistical analysis tool set is similar.

Pfammatter and Jones eventually agreed that they might work well as a team. We were working on different subjects, but we had a lot in common; its worked out fabulously, said Jones. There was a learning curve, but its all gone very well. Im really proud of Jesse.

Beyond the lab, Pfammatter loves outdoor adventures and likes to paint mountain scenes, but lately there hasnt been time. He and wife Rachel recently finished home renovations, and in early June they embarked on their next big adventurethe birth of their son.

About the ILAE Journal Prizes

Each year, the ILAE awards one Basic Science and one Clinical Science Prize to the first authors of original research articles published inEpilepsia Open during the preceding year. Awardees are nominated and selected by the journal's editorial board, the editors-in-chief, and the ILAE president.

The prize is intended to stimulate excellence in epilepsy research and reward young researchers for outstanding contributions to the field.

Watch the 2020 Journal Prize Symposium on YouTube, including a talk by Dr. Pfammatter about his research.

Founded in 1909, the International League Against Epilepsy (ILAE) is a global organization with more than 120 national chapters.

Through promoting research, education and training to improve the diagnosis, treatment and prevention of the disease, ILAE is working toward a world where no persons life is limited by epilepsy.

To learn more, visit ourwebsite(available in multiple languages) or find us onFacebook.

We're also on Twitter inEnglish,French,Japanese,PortugueseandSpanish.

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Harnessing complexity to advance epilepsy research: Learning the language of EEG spike-wave discharges - Newswise