Category Archives: Physiology

NMSU’s Rentfrow Hall named after long-time registrar for her dedication to students – New Mexico State University NewsCenter

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Rentfrow Hall was originally constructed in 1958 as a womens gymnasium and named for Era Rentfrow, after she served as the universitys registrar for 40 years. The gym was the home for the Department of Physical Education and Recreation, which eventually became the College of Educations Department of Kinesiology and Dance.

/>About Era Rentfrow

Rentfrow was born in 1898 and moved to Mesilla Park at an early age. She attended the college's preparatory school, graduating as president of her class in 1915. She then enrolled at the New Mexico College of Agriculture & Mechanic Arts as one of 23 entering freshmen.

After graduation in 1919, she began a lifelong career of service at the college. In 1922, Rentfrow was promoted and became the college registrar. In addition to her duties as registrar, she was responsible for sending out publicity to prospective students, issuing student activity cards, supervising ticket sales for all college programs and much more.

Rentfrow frequently used personal funds to make loans to students to cover their tuition, board, or books. She was proud of the fact that all students repaid these loans, no matter how long it took. She found inspiration in student success.

Rentfrow was engaged to Joe Quesenberry, a student at New Mexico A&M and captain of the football team. He was the first Aggie killed in combat during World War I. She never married after his death.

Perhaps motivated by the loss of her fianc, Rentfrow tracked and chronicled the Aggies who served during World War II. She dedicated herself to preserving the memory of the 126 Aggies who did not come home. Recognizing the need to secure their place in history, she gathered their photographs and biographical information from families and loved ones. The photos displayed in the rededicated Memorial Tower honor their memory.

In 1962, after 40 years as university registrar, she retired. She is credited as having one of the biggest impacts on the lives of students during this period. Shortly after her retirement, Rentfrow Hall was named in her honor.

Historic significance

Rentfrow Hall sits almost in the exact geographical center of the NMSU campus near the corner of Stewart and Williams. The architect is listed as unknown. The one-story building was constructed with stuccoed walls, brick surrounds, ceramic tile mullions and jalousie windows with sidelights and transom windows.

An evaluation of the building in the 2009 Heritage Preservation Plan determined the building did not meet the level of architectural or historical significance to warrant a determination of eligibility on the National Historic Register. Rentfrow Hall was slated for demolition as part of NMSUs Master Plan.

Rentfrows legacy and importance to NMSU history may have played a role in the buildings renovation. In the preservation plan, evaluators insisted the name Era Rentfrow should be carried forward on another campus building of similar visibility and import. Siting her history of helping students and her long tenure at the university as well as an endowment in her name, the preservation plan states: She is an important figure in the history of NMSU and the honor of her name should continue. The building was not demolished and instead was renovated, thanks to a bond election five years later.

Rentfrow Hall undergoes a major renovation

The growing Department of Kinesiology and Dance housed in Rentfrow Hall needed major renovation after nearly 60 years without any upgrades. A floor-to-ceiling remodel began in April 2016, funded with $2.9 million from the 2014 General Obligation Bond. The renovation was completed in Fall 2017.

The project added a 2,700 square-foot dance studio, additional restroom space and renovated a 12,000 square-foot gymnasium, which was converted into two dance studios. Those studios are now divided by a retractable wall with retractable bleachers for public performances. Studio spaces are used as rehearsal spaces for students to practice choreography. Two labs for the kinesiology program also were added to the building. One is a Biochemistry and Molecular Exercise Physiology lab while the other is for Applied Exercise Physiology.

NMSU History Archives

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NMSU's Rentfrow Hall named after long-time registrar for her dedication to students - New Mexico State University NewsCenter

Affluent Medical kicks off first-in-human trial of Epygon valve – BioWorld Online

French startup Affluent Medical SA has launched a European pilot study in humans of its native-like transcatheter mitral valve technology. The Epygon valve is designed to restore the normal blood flow vortex in the left side of the heart and treat left ventricle disease, particularly in so-called functional patients.

Coinciding with the launch of the pilot, the company announced 10.3 million (US$11.6 million) in new financing and the addition of three new members on its board of directors.

According to the Aix-en-Provence company, the Epygon valves asymmetric, D-shaped and one-leaflet design allows it to restore the natural vortex, a rotational blood flow that is thought to be more efficient that a straight, steady flow. To our knowledge, no other mitral valve in development is a one-leaflet allowing the restore the physiological vortex, CEO Michel Finance told BioWorld.

The unique design is expected to result in high procedural success, restore left ventricular blood flow and avoid thrombus formation and left ventricular outflow tract (LVOT) obstruction, while also reducing left ventricular effort.

Finance called the pilot study a major milestone for the company.

Epygon is a world premiere and a potential best-in-class valve in a market where physiology has been overlooked for decades, he said. This pilot study aims to confirm the improved clinical outcomes already demonstrated in preclinical testing. It should open up a new era both for surgeons and patients, with physiology as a key factor in cardiac surgery.

CE mark pivotal study targeted for 2022

Affluent Medical estimates that as many as 4 million people in the U.S., Europe and Asia suffer from mitral valve regurgitation, due to the lack of optimal therapies. The global market is expected to reach $3.5 billion to $5 billion by the end of 2022, growing at an annual rate of 35%.

The prospective, nonrandomized, single-arm, multicenter MINERVA (Mitral valve INsufficiency with the Epygon TRanscatheter mitral VAlve system) study will enroll up to 20 patients in three centers in Austria, Italy and Spain. Affluent Medical plans to complete enrollment by the first quarter of 2021 and report the results after one year of follow-up.

We are anticipating our first human implant in the next weeks, Finance said.

If the pilot study is successful, the company plans to launch a pivotal trial to support CE marking of the Epygon valve in early 2022.

Finance said the company will be pursuing a similar approach for U.S. FDA approval, starting most probably in the next six to 12 months.

Capital injection

The 10.3 million private placement financing was led by Truffle Capital via the Truffle Biomedtech FCPI Fund and Truffle Innov FRR France. Other participants included Head Leader Ltd., Affluent Medicals partner for two ventures in Shanghai, Ginko Invest, Fate and Simone Merkle. The company has earmarked the funds to advance its cardiology clinical programs, particularly the MINERVA study, completion of its OPTIMISE II pivotal trial of Kalios, an adjustable mitral ring, as well as the start of a pilot/pivotal study of its Artus implantable urinary sphincter for urinary incontinence.

The OPTIMISE II trial got underway in December and is slated to complete enrollment of about 62 patients in four European countries this quarter. The goal is to demonstrate Kalios safety and effectiveness as a treatment for post-operative residual valve insufficiency. Primary outcomes from the trial are after 12-month follow-up early next year, with commercialization possibly in about two years, Finance said.

Additionally, Affluent Medical announced 5.5 million (US$6.2 million) in financing from two government-backed loans: 2.2 million from the banks Socit Gnrale and BNP Paribas to mitigate COVID-19s economic impact; 1 million by Bpifrance to support cardiology R&D; and 2.3 million in grants from Bifrance for the MINERVA study.

The new funding brings Affluent Medicals total capital raised to about 38 million since 2012.

In conjunction with the financing, the company named Jean-Franois Le Bigot, CEO of Oncovita and chairman of Ginko Invest, and Benot Adelus, president of Fate, as board members. Rounding out the board appointments was Finance, who was elected as chairman.

We are very pleased to welcome Jean-Franois Le Bigot and Benot Adelus to our board of directors, Finance said. Their expertise along with the 15.8 million in refinancing should allow Affluent Medical to make rapid progress on its clinical programs and its commitment to bring new-generation, minimally invasive medical devices to the market for the treatment of large unmet medical needs.

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Affluent Medical kicks off first-in-human trial of Epygon valve - BioWorld Online

USF researchers working to find early warnings for severe COVID-19 illness – ABC Action News

TAMPA, Fla. -- Researchers at the University of South Florida are working to identify the physiological response to COVID-19, in hopes of developing an early warning system for patients who may be at risk for severe illness.

Researchers explained their goal is to understand which physiological patterns may give an indicator of a more serious infection.

Well be able to define how long people have these different abnormalities, their vital signs, their activity level, their heart so that we will know more about how to triage patients, characterize patients, tell them what to expect coming down the line on different days of their illness, said Dr. Asa Oxner, an associate professor at USF and operations director of the TGH-USF Health COVID Clinic.

What we intend to do is monitor a large enough sample population of people who have contracted the COVID virus but do not have otherwise some other secondary condition that would indicate they are at high risk and see if we can identify relative to their those outcomes which of the variables might give us an early indication that for a particular physiology youre going sideways, said Dr. Matthew Mallarkey, director of the USF Muma College of Businesss Doctor of Business Administration Program.

They are monitoring up to 150 COVID-19 patients with no underlying risk factors for up to a month after their diagnosis. The patients will wear a device from Shimmer Research Inc., partnering with USF on the study, to measure things like heart rate, oxygen, heart rhythm and activate levels.

Unfortunately, COVID-19 is likely to be with us for a while. By monitoring patients, we can direct healthcare resources to those who really need it and intervene in severe cases before they turn critical. This can be done remotely without bringing infectious patients to hospitals or doctors offices where they can infect other people. We are excited to work with the excellent team at USF, who bring world-class medical and AI expertise to this project, the company stated.

Researchers said theyll look at the data to see if there are the same signs in patients.

We can look back on the ones who got worse, what was the first sign that theyre about to get worse and do they all have the same sign? If they did, thats very very helpful for the people out in the community. We could have patients self-monitor that or we could have primary care doctors self-monitor that so that we would know whos gonna get sick and we know early as possible so we can start changing things for them, said Oxner.

Were hearing about sports teams, for example, where whole teams -- one or two members of the team -- contract the virus and maybe whole teams are at risk of contracting the virus. We would imagine that theres a better world where those otherwise healthy young adults are given a wearable device that could continuously monitor and compare their physiologies to these identified archetypes that these archetypes that are gonna go sideways and they dont go sideways for the same reason, said Mallarkey.

The project is funded through the USF COVID-19 Rapid Response Grant.

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USF researchers working to find early warnings for severe COVID-19 illness - ABC Action News

Local students named to U of I Dean’s List – Oskaloosa Herald

IOWA CITY More than 8,500 undergraduate students at the University of Iowa were named to the dean's list for the 2020 spring semester, including 47 students from Mahaska and Marion Counties.

The following students were named to the list:

Austin Adrian of Pella, Accounting; Chance Bodart of Oskaloosa, Journalism and Mass Communication; Payton Bumgardner of Pleasantville, History; Allison Clark of Leighton, History; Spencer De Jong of Oskaloosa, History; Alicia Edmundson of New Sharon, English and Creative Writing; Taylor Fleener of Oskaloosa, Anthropology; John Hammes of Oskaloosa, Economics; Kaila Hembrook of Knoxville, Communication Studies; Tessa Hutchings of Pleasantville, Art; Kaley Iddings of Pleasantville, Speech and Hearing Science; Anna Kain of Oskaloosa, Art; Emma Kelderman of Oskaloosa, Pre-Business; Joseph Kesteloot of Knoxville, Microbiology; Makayla Kruse of Pella, Human Physiology; Alice Lickteig of Pella, Elementary Education; Isaiah Martin of Pella, Actuarial Science; Emily Masek of Otley, Speech and Hearing Science; Blake McClung of Knoxville, Business Analytics and Information Systems; Jared McClung of Knoxville, Mechanical Engineering; Jackson McDonald of Knoxville, Communication Studies; Bailee Meyer of Pella, English Education; Carson Milledge of Oskaloosa, Computer Science; Aubrey Miller of Oskaloosa, Elementary Education; John Moore of Oskaloosa, Finance; Maria Moore of Hamilton, Geoscience; Camryn Norton of Knoxville, Environmental Engineering; Lucy Olson of Knoxville, Neuroscience; Emma Padellford of Pleasantville, Enterprise Leadership; Victoria Palmer of Oskaloosa, Health and Human Physiology; Emily Parker of Pleasantville, English; Aleona Pronina of Pella, Psychology; Jarod Robertson of Pella, Art; Cara Roquet of Fremont, Elementary Education; Joel Ruiter of Otley, Human Physiology; Jordyn Sanders of Bussey, Science Studies; Victoria Sheehey of Pleasantville, Art; Colton Spaur of Bussey, Sport and Recreation Management; Kelli Spaur of Bussey, English; Andelyn Sunderman of Pella, Communication Studies; Daniel Thompson of Pella, Music Education; Morgan Thorpe of Pleasantville, Speech and Hearing Science; Tianna Torrejon of Pleasantville, Journalism and Mass Communication; Colin Vasina of Pella, Management; Jessica Vogel of Pella, Ancient Civilization; College: Josephine Vroom of Pella, Management; and Jennifer Wieser of Pella, Management.

We are making critical coverage of the coronavirus available for free. Please consider subscribing so we can continue to bring you the latest news and information on this developing story.

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Local students named to U of I Dean's List - Oskaloosa Herald

Prevalence of Diabetic Retinopathy and Its Associated Factors among Di | DMSO – Dove Medical Press

Melkamu Tilahun,1 Teshome Gobena,2 Diriba Dereje,2 Mengistu Welde,2 Getachew Yideg3

1Department of Biomedical Sciences (Medical Physiology), College of Medicine and Health Sciences, Debre Markos University, Debre Markos, Ethiopia; 2Department of Biomedical Sciences, College of Medicine and Health Sciences, Jimma University, Jimma, Ethiopia; 3Department of Biomedical Sciences (Medical Physiology), College of Medicine and Health Sciences, Debre Tabur University, Debre Tabur, Ethiopia

Correspondence: Melkamu TilahunDepartment of Biomedical Sciences (Medical Physiology), College of Medicine and Health Sciences, Debre Markos University, PO Box 269, Debre Markos, EthiopiaTel +251 93-355-5884Fax + 0587780673Email melkamutilahunalamir@gmail.com

Background: Diabetic retinopathy is a well-known sight-threatening microvascular complication of diabetes mellitus. Currently, 93 million people live with diabetic retinopathy worldwide. There are insufficient studies addressing the prevalence of diabetic retinopathy and risk factors in Ethiopia.Objective: To assess the prevalence of diabetic retinopathy and its associated factors among diabetic patients on follow-up at Debre Markos Referral Hospital, northwest Ethiopia, 2019.Methods: This institution- based cross-sectional study was conducted among 302 patients. They were selected through systematic sampling. Explanatory data were extracted from medical records and interviews. Blood pressure, weight, height, and visual acuity tests were assessed. Retinal examination was performed with a Topcon TRC-NW7SF fundus camera. Data were entered in EpiData 3.1 and exported in to SPSS 20 for analyses. Binary logistic regression with 95% CIs was used for analyses. Simple binary logistic regression followed by multiple binary logistic regression analysis was conducted to identify associated factors.Results: There were 302 patients in this study, of which 57 (18.9%) had diabetic retinopathy. Among the diabetic retinopathy patients, 75.4% had the preproliferative type. Four in ten (37.7%) of the patients had visual acuity problems. Poor glycemic control (AOR 4.58, 95% CI 1.86 11.31), > 10 years diabetes duration (AOR 3.91, 95% CI 1.86 8.23), body-mass index > 25 kg/m2 (AOR 3.74, 95% CI 1.83 7.66), and hypertension (AOR 3.39, 95% CI 1.64 7.02) were factors significantly associated with diabetic retinopathy.Conclusion: About a-fifth of diabetic patients had diabetic retinopathy. Diabetic retinopathy was significantly associated with glycemic control, hypertension, body-mass index, and duration of illness. Routine assessment and early control of those associated factors may be important in reducing both the prevalence and impact of diabetic retinopathy, as evidenced in the current study.

Keywords: diabetes mellitus, diabetic retinopathy, associated factor, Ethiopia

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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Empatica and BARDA Join Forces to Validate Wearable System That Detects COVID-19 Before Symptoms Appear – PRNewswire

The aim is to validate Empatica's algorithm in real-life settings, with the participation of healthcare workers who are exposed to a high viral load while treating hospitalized COVID-19 patients.They will wear the E4, Empatica's medical-grade research wearable wristband, for 30 days, and their physiological data will be reviewed against daily nasopharyngeal (NP) samples and a daily qRT-PCR swab, ensuring the highest ground truth.

Empatica CEO Matteo Lai, stated, "We are very proud to join forces with BARDA to help improve the health and safety of millions of Americans going back to work. This product introduces a new paradigm: empowering individuals and institutions with smart health monitoring, so that they will know early when they need to self-isolate and take care of themselves. Without BARDA's leadership and foresight over the past year, our early detection algorithm would not have reached this pivotal stage of clinical validation, which will accelerate our request for FDA's approval of Aura as a medical product for use by people at risk of contracting COVID-19."

BARDA Acting Director, Gary Disbrow, Ph.D., added, "We anticipate that access to real-time and actionable health information will empower people to seek medical advice and care sooner, or to adopt behavioral changes such as temporary self-isolation that can help reduce the spread of COVID-19 and similar infections."

Early detection can protect frontline workers, reduce spread, and improve the overall public health response as lockdowns ease globally. Recent estimates byCDC suggest that 35% of infections are asymptomatic, making contact tracing and containment of the virus a challenge. Meanwhile,the most infectious period could be 1 to 3 days before symptoms start, so even those patients who eventually display symptoms can still infect their family, colleagues and other people they interact with, before realizing they are ill. Digital biomarkers like Aura can help efficiently triage patients, enabling more effective care and prioritization of cases, and potentially saving lives.

Contact [emailprotected] for more info on Aura.

Empatica

Empatica Incis an MIT spinoff based in Boston, MA, and a pioneer in physiology-based biomarker development and continuous, unobtrusive patient monitoring driven by AI. Empatica's platform uses a combination of biosensors to detect features of human physiology that are distilled in AI-based algorithms and can remotely monitor autonomic activity, movement, sleep and cardiac activity. Empatica's E4 and Embrace2 smartwatches are CE-marked and have been sold to thousands of institutional partners for research purposes, in trials and studies examining Stress, Sleep, Epilepsy, Migraine, Depression, Addiction and other conditions.

HHS/ASPR/BARDA

HHS works to enhance and protect the health and well-being of all Americans, providing for effective health and human services and fostering advances in medicine, public health, and social services. The mission of ASPR is to save lives and protect Americans from 21st century health security threats. Within ASPR, BARDA invests in the innovation, advanced research and development, acquisition, and manufacturing of medical countermeasures vaccines, treatments, diagnostic tools, and non-pharmaceutical products needed to combat health security threats.

SOURCE Empatica

https://www.empatica.com/

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Empatica and BARDA Join Forces to Validate Wearable System That Detects COVID-19 Before Symptoms Appear - PRNewswire

Navy Clear on Causes of Physiological Events in Pilots; Final Recommendations Released for PE Mitigation – USNI News

Lt. Joshua Chester, a Navy pilot from Corton, West Virginia, poses in front of an F/A-18E Super Hornet, assigned to the Sunliners of Strike Fighter Squadron (VFA) 81 on the flight deck of the Nimitz-class aircraft carrier USS Harry S. Truman (CVN-75) in the Atlantic Ocean. US Navy Photo

The Navy now understands what has been causing physiological events in aviators which spiked so sharply in 2017 that flight instructors refused to get into their jets to train new student pilots with a recently completed root cause analysis pointing to a complex relationship between aircrew, their flight gear and their aircraft.

Rear Adm. Fredrick Luchtman, the commander of the Naval Safety Center and the lead of the Physiological Episodes Action Team (PEAT), told reporters today that two root cause corrective action (RCCA) teams one looking at the T-45 Goshawk trainer jet and one looking at the F-18 family of fighters had completed their work in December and briefed naval aviation leaders in February on their findings. The teams spent three years and $50 million on this work, drafting more than 8,000 pages of technical documentation and proposing combined 567 recommendations for how to keep pilots and weapons officers safer in the cockpit in the future.

Ultimately, the teams found that there was no simple fix. Despite early theories, the PEs werent caused by contaminated air, a lack of oxygen or systems not designed well enough to keep humans safe in harsh environments.

The bad news is that theres no single causal factor that leads to physiological events, Luchtman told reporters today, though he noted that a string of pilot programs and early mitigation efforts to tackle contributing factors have already resulted in a 96-percent decrease in the PE rate in the T-45 fleet, and a 74-percent reduction in the PE rate in the F-18 fleet since 2017.

Physiological events fall in two main categories: those related to oxygen in the air, and those related to air pressure. Luchtman said its not as simple as the systems that control these two factors not working; rather, breathing concentrated oxygen in a small cockpit with restrictive flight gear is hard on the body, and something as simple as a mask not fitting quite right could lead to PE symptoms.

Though physiological episodes have long existed, Luchtman said with symptoms ranging from headaches to tingly fingers to dizziness to loss of consciousness around 2010 the naval aviation community started to see a rise in PEs believed to be related to aircraft malfunctions. That combination of a physiological episode related to an aircraft malfunction was dubbed a physiological event Luchtman noted and apologized for the confusion between the names of physiological episodes and the subcategory of physiological events. In 2017, physiological events skyrocketed with T-45s reaching their highest PE rates in March and F-18s in November.

After a comprehensive review was released in June 2017 and the RCCA teams were created shortly after, early theories emerged. One was that pilots were breathing in contaminated air from the Onboard Oxygen Generating System (OBOGS).

It was an early theory, its a valid theory and we needed to address it. And contamination could be a logical theory in both those aircraft, so we addressed it with both root cause corrective action teams. The bottom line is that the teams took over 21,000 samples of air from naval aircraft over the course of 20 months, and there were compounds identified, as you can imagine, but they were in such small amounts that a team of medical doctors and toxicologists concluded that the presence of those compounds in those amounts would not result in physiological symptoms, Luchtman said.

Sailors assigned to Aviation Survival Training Command, Norfolk operate a normobaric hypoxia trainer (NHT). An NHT allows for safer hypoxia training for pilots and aircrewman while providing a more realistic experience on Jan. 27, 2020. US Navy Photo

To be sure, the Navy asked a team from Johns Hopkins University to review the data, and they agreed: the air provided by Navy onboard oxygen generating systems, which we abbreviate OBOGS, is and was extremely clean, Luchtman said.

Another early theory was that aircrews werent getting enough oxygen, leading to hypoxia.

We took a hard, hard look at that, and after extensive testing this theory has been disproven, the rear admiral said.

A final theory questioned the basic design of OBOGS and the Environmental Control System (ECS) that controls air pressure in the F-18 cabin, suggesting that the systems were not suitable to protect human health while the jets flew challenging flight profiles. Luchtman said the testing proved the two systems were robust.

So what was causing the hundreds of PEs naval aviators reported?

On the F-18s the legacy F/A-18A-D Hornets, the newer F/A-18E/F Super Hornets and the electronic warfare EA-18G Growlers Luchtman said both oxygen- and pressure-related PEs had been occurring.

On the oxygen side, the air produced by OBOGS was found to be clean, and though aviators showed symptoms of hypoxia, it turned out they didnt actually have hypoxia where the bodys tissues are deprived of sufficient oxygen.

Instead, even under benign conditions, the act of breathing highly concentrated air from a closed-loop system while encumbered by bulky flight gear in a cramped cockpit is not easy. And in the dynamic environment of a fighter cockpit, we also add to the equation temperature variance, exposure to continual changes in Gs and pressure, all while managing an overwhelming amount of sensory input. All this amounts to increased what we call work of breathing. Over time, increased levels of work of breathing can lead to fatigue and changes in breathing patterns, leading to inefficient gas exchange, and many of those symptoms look a lot like hypoxia, he said.

Aviation Structural Mechanic 3rd Class Jeffery Hendricks removes a screw from an Onboard Oxygen Generating System (OBOGS) while performing special maintenance in the airframes shop aboard the Nimitz-Class nuclear powered aircraft carrier USS Harry S. Truman (CVN 75) on Jan. 5, 2008. US Navy photo.

Further, the F-18 RCCA team found that work of breathing could also be affected by improperly fit or worn flight gear, malfunctions in the oxygen mask, and malfunctions of the OBOGS unit itself, Luchtman added. Though OBOGS has an alert system to warn pilots if it malfunctions, there is no such alert for flight gear and masks that dont fit, arent being worn properly or have experienced some kind of malfunction. Luchtman said efforts to create some kind of gear alert system are immature at this point, but that the Navy is trying to explore this avenue to protect pilots against failures in the gear meant to protect their bodies.

In the meantime, based on everything weve learned about human physiology through research and testing, many of our training syllabi are under modification to address some of those shortfalls in training related to the flight gear and masks including a course that would teach maintainers how to properly pack parachutes and other gear with PE-avoidance in mind.

On the air pressure side, which Luchtman said tends to cause more severe PEs, the OBOGS design was fine, but components of it had been failing and causing pressure anomalies that might not affect some aircrew but did cause PE symptoms in others.

On the legacy Hornets, the Navy set strict limits on how long OBOGS components can be used in an aircraft before being replaced and mandated periodic inspections. Luchtman said this was the single most important thing the Navy did for legacy Hornets, leading to an 88-percent reduction in pressure-related PEs. Similar component replacement requirements have been put in place for the Super Hornets and Growlers, and the admiral said that redesign efforts are ongoing for many of the components the two most important being the primary and secondary bleed air valves to create new parts that are more reliable and can go longer between replacement.

He praised Naval Air Systems Command for sending aircrew up with a small slam stick to record air pressure, which after flights was downloaded and paired with aircraft maintenance data. Through data analytics, he said, NAVAIR has created a Hornet Health Assessment Readiness Tool (HhART) that can now identify components that are sub-performing and flag them for replacement before a failure and possible a PE ever occur.

Think of the significance of that: that is a tremendous paradigm shift in the way we do maintenance, we can actually identify parts that are sub-performing, replace those parts and prevent the PE from ever happening, he said.

Since the HhART pilot program kicked off in January 2019, pressure-related PEs in F-18s overall are down 80 percent.

Finally, he said, the F-18 RCCA team looked at aeromedical factors such as dehydration, fatigue, diet, hypoglycemia, stress, physical conditioning and more.

A T-45C Goshawk training aircraft assigned to Training Air Wing (TW) 2 lands on the flight deck of the aircraft carrier USS John C. Stennis (CVN-74) in the Atlantic Ocean on Dec. 9, 2019. US Navy Photo

We shouldnt be surprised that if you go flying dehydrated and youre breathing dry air from our OBOGS concentrator, that youre not going to feel well after awhile, Luchtman said.

On the T-45 side, Luchtman said the RCCA team came closer to a single root cause: with the PEs primarily being oxygen-related rather than pressure-related, the team narrowed in on the airflow from the engine to the OBOGS and then into the cockpit. While the air coming out of OBOGS was clean, in some flight profiles the engine wasnt putting out much air, meaning the OBOGS wasnt taking in much air to purify, and therefore the aircrewtemporarilywerent getting as much air out of OBOGS.

In two relatively simple changes, the RCCA team recommended straightening out what had been an angled pipe to bring air from the engine to the OBOGS, increasing overall air flow, as well as altering the engine to increase the rotations per minute so it would spin faster and provide more air to OBOGS.

Those two things, along with implementation of an ECS hygiene inspection regimen, has resulted in a 96-percent reduction in the PE rate across the T-45 fleet since its peak rate in March of 2017. So I think thats actually a pretty good news story, he said.

Despite the significant decreases in PEs since 2017, they havent ceased altogether. Luchtman told USNI News that between October 2019 and the end of May the first eight months of Fiscal Year 2020 the Navy had seen 27 PEs across all Navy aircraft types. Just one of those was in the T-45, with 20 coming from F-18s and six coming from other kinds of non-fighter aircraft.

This compares to 35 PEs in T-45s in FY 2016, 31 in 2017, six in 2018 and one in the first half of 2019, USNI News previously reported. In the F-18s, there had been 87 PEs in FY 2016, 73 in 2017, 65 in 2018, and 41 in the first half of FY 2019.

To continue working to eliminate PEs, Luchtman said several initiatives are ongoing. The PE Action Team, which he led for two years previously out of Arlington, Va., was recently pulled under the Naval Safety Center in Norfolk, Va. The relocated office has continued funding for several initiatives, he said.

Cmdr. Leslie Mintz, executive officer of the Blacklions of Strike Fighter Squadron (VFA) 213, inspects an F/A-18F Super Hornet prior to her flight on board Naval Air Station Oceana, Va., on Feb 28, 2019. US Navy Photo

Soon the Navy will install a Cockpit Pressure and OBOGS Monitoring System (CPOMS) into all F-18s more than 1,000 jets, USNI News has previously reported which will record oxygen concentration levels and pressurization data from cockpit and alert air crew if either level is off.

Luchtman told USNI News in an interview last year that CPOMS involves some pretty significant engineering modification to the aircraft. That will be done by professionals from Boeing, and its going to take 10 to 14 days per aircraft, times over 1,000 aircraft. Weve never done anything of that scale before.

Additionally, a Life Support Systems Integration for the F-18s will include a new OBOGS concentrator, as well as the ability to electronically schedule oxygen delivery to the aircrew based on their altitude a capability the Navy wanted before but hadnt been able to achieve. LSSI, which will also bring additional data recording capabilities, is still several years from being operational.

On the T-45s, the OBOGS will get a new concentrator, though Luchtman said that was more of a routine modernization project rather than an attempt to address a specific PE concern. To address PEs, though, an automatic backup system will be installed where, if oxygen levels dip below a certain threshold, a liquid oxygen bottle will spray a bit of 100-percent oxygen into the cockpit for the aircrew.

Luchtman said Navy leadership has been very supportive of this effort and has fully funded all these modifications.

He added that at least 30 more studies are in the hopper for the Navy to continue to better understand aeromedical factors, and that hopefully monitoring systems could be developed to help aircrew identify when they may be on the cusp of a PE and prevent it from happening in the first place.

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Navy Clear on Causes of Physiological Events in Pilots; Final Recommendations Released for PE Mitigation - USNI News

How to help your chickens beat the heat in summer – The Poultry Site

Last year we experienced record-breaking temperatures across the UK, peaking in Faversham, Kent at 35.3oC. With the expected rise in global temperatures those sweltering summer months could be beyond our current means of coping with the heat. Every summer we experience days when just spending a few minutes in a poultry house feels unbearable, and for many broilers reaching the end of the cycle it is with mortality soaring. Thankfully the poultry industry has made a great deal of progress in the area of ventilation and cooling. As chickens are reared in hot countries such as Saudi Arabia, the technology to deal with temperatures in excess of 40oC has already been well tested.

Chickens, in general, can cope with high temperatures. The domestic fowl has a healthy body temperature of between 40C and 41.7oC, chicks under three weeks of age being at the lower end. With the birds metabolism being quite high, its ability to lose heat is imperative and it does this by radiation, conduction and the evaporation of water. Chicks, being small, have a high surface area in comparison to their body mass, which means heat is lost from the body relatively easily; as the bird increases in size this ratio changes, though, and for the hefty 3kg broiler radiation of heat via the skin is not going to be enough to keep its temperature down.

When radiation is insufficient you will see other behaviours presented: the bird will increase its surface area by lifting its wings, exposing the less feathered parts of its body; the flock will also try to move to a cooler area, away from the heat source, perhaps into the shade; or the birds will clear soil and litter away to make a cool depression.

Heat loss via conduction can only occur if the chicken is in direct contact with a substance that is cooler than itself. This could be the ground, as seen in the hollow-digging behaviour. In the main, though, conduction will occur in a well-ventilated area where the skin can contact cooler air.

Evaporation is the final key to cooling off. Like other animals that lack sweat glands, chickens main evaporative apparatus is the respiratory system and they will typically pant once temperatures become uncomfortable. Panting uses a lot of energy; this will be reflected in an increase in food consumption once the temperature starts moving toward 30oC.

Knowing how the physiology of the bird handles excess heat enables us to design environments and conditions that will support chickens in keeping cool. Space is an essential element when birds need to radiate heat, and therefore stocking densities should be reduced in the summer months. On a still day in naturally ventilated housing, you only have convection to pull the air across your birds and that is a fine balance steep roofs and tall chimneys will help increase air speed and throughput. You must maintain a minimum of ventilation rate at all times, and this can be calculated using feed consumption as a baseline, plus other factors including physiology of the birds and humidity.

Heat management in extensive systems is less of an issue, but a simple provision of shade and access to water will help tremendously. If local planning will allow, use light-coloured roofing materials. Its tricky but if you can check air speed in the house you will find that there is an optimum amount of inlet area to outlet. Too much inlet area can slow air movement in the house, so aim for a 1:1 ratio for inlet to outlet area as a guide. In a naturally ventilated building, consider placing the whole building in the shade of trees or orienting it so the sun is not blazing down on the broadside at noon. Where a source of power is available, place circulating fans around the house to get the air moving. Its important to stress that still air is a killer even in slightly elevated temperatures.

Another key element of hot-weather management is keeping the birds calm, so stick to your normal routine and avoid entering the house at the hottest part of the day. Activities such as weighing birds, routine maintenance and depletion should be postponed or relegated to early mornings.

Once you move into the realm of intensive production and complete environmental control, get it right and its plain sailing. Tweak a few buttons and gauges and the environment within the building can be optimised regardless of conditions outside. Get it wrong, though, and you could literally lose your entire flock through heat exhaustion and suffocation.

Modern intensive poultry farmers have a whole range of technologies and management tools they can use to mitigate the harshest of climatic conditions. Its important to start with the physiology and behaviour of the chicken. We can assist the chicken in optimising its body temperature by either supplying air at the right temperature or by enabling the chicken to effectively control its body temperature a combination of both will move us toward the most efficient system.

Air cooling is not widely used in the UK as it is very expensive. Air can be cooled by introducing cold water via a fine spray into the air inlet. This in principle sounds ideal; in reality there is a very fine balance between cooling the air sufficiently and not increasing the humidity to a point whereby the chickens are unable to effectively respire water away from themselves and consequently are unable to cool down. Increased humidity can also lead to an increase in moulds throughout the housing and a deterioration in the fabric of the building. Increasing the airs humidity also increases its mass, meaning that it will tend to hang around the birds rather than being lifted away from them. A better system is one in which air passes through a cooler, which is the same as a radiator only cold water is passed through the vanes cooling the air as it passes through.

Increasing air throughput to the house is the preferred method in our climate. This has been used to great effect in housing with tunnel ventilation, whereby the long broiler house becomes a tunnel with huge fans at one end and inlets covering the wall of the other end. There is, however, a limit to this system: if air speed through the flock exceeds 1.5m per second, it will create a significant wind chill, having a detrimental effect on the birds.

As summer temperatures rise and production is further challenged, other methods of keeping birds cool will no doubt come to the fore but ultimately it is the chickens physiology that will set the limits.

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How to help your chickens beat the heat in summer - The Poultry Site

Nanotoxicology of Dendrimers in the Mammalian Heart: ex vivo and in vi | IJN – Dove Medical Press

Fawzi Babiker,1 Ibrahim F Benter,2 Saghir Akhtar3

1Department of Physiology, Faculty of Medicine, Health Science Center, Kuwait University, Kuwait City, Kuwait; 2Faculty of Medicine, Eastern Mediterranean University, Famagusta, North Cyprus, Republic of Cyprus; 3College of Medicine, QU Health, Qatar University, Doha, Qatar

Correspondence: Fawzi BabikerDepartment of Physiology, Faculty of Medicine, Health Science Center, Kuwait University, PO Box 24923, Safat 13110, Kuwait, Tel +965 24636360Fax +965 25338937Email Fawzi.b@hsc.edu.kwSaghir AkhtarCollege of Medicine, QU Health, Qatar University, PO Box 2713, Doha, QatarTel +974-4403 7865Email s.akhtar@qu.edu.qa

Aim: The effects of polyamidoamine (PAMAM) dendrimers on the mammalian heart are not completely understood. In this study, we have investigated the effects of a sixth-generation cationic dendrimer (G6 PAMAM) on cardiac function in control and diabetic rat hearts following ischemia-reperfusion (I/R) injury.Methods: Isolated hearts from healthy non-diabetic (Ctr) male Wistar rats were subjected to ischemia and reperfusion (I/R). LV contractility and hemodynamics data were computed digitally whereas cardiac damage following I/R injury was assessed by measuring cardiac enzymes. For ex vivo acute exposure experiments, G6 PAMAM was administered during the first 10 mins of reperfusion in Ctr animals. In chronic in vivo studies, nondiabetic rats (Ctr) received either vehicle or daily i.p. injections of G6 PAMAM (40 mg/kg) for 4 weeks. Diabetic (D) animals received either vehicle or daily i.p. injections of G6 PAMAM (10, 20 or 40 mg/kg) for 4 weeks. The impact of G6 PAMAM on pacing-postconditioning (PPC) was also studied in Ctr and D rats.Results: In ex vivo studies, acute administration of G6 PAMAM to isolated Ctr hearts during reperfusion dose-dependently impaired recovery of cardiac hemodynamics and vascular dynamics parameters following I/R injury. Chronic daily i.p. injections of G6 PAMAM significantly (P< 0.01) impaired recovery of cardiac function following I/R injury in nondiabetic animals but this was not generally observed in diabetic animals except for CF which was impaired by about 50%. G6 PAMAM treatment completely blocked the protective effects of PPC in the Ctr animals.Conclusion: Acute ex vivo or chronic in vivo treatment with naked G6 PAMAM dendrimer can significantly compromise recovery of non-diabetic hearts from I/R injury and can further negate the beneficial effects of PPC. Our findings are therefore extremely important in the nanotoxicological evaluation of G6 PAMAM dendrimers for potential clinical applications in physiological and pathological settings.

Keywords: PAMAM, postconditioning, diabetes, ischemia, reperfusion

This work is published and licensed by Dove Medical Press Limited. The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution - Non Commercial (unported, v3.0) License.By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. For permission for commercial use of this work, please see paragraphs 4.2 and 5 of our Terms.

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Nanotoxicology of Dendrimers in the Mammalian Heart: ex vivo and in vi | IJN - Dove Medical Press

Climate-driven risks to the climate mitigation potential of forests – Science Magazine

Risks to mitigation potential of forests

Much recent attention has focused on the potential of trees and forests to mitigate ongoing climate change by acting as sinks for carbon. Anderegg et al. review the growing evidence that forests' climate mitigation potential is increasingly at risk from a range of adversities that limit forest growth and health. These include physical factors such as drought and fire and biotic factors, including the depredations of insect herbivores and fungal pathogens. Full assessment and quantification of these risks, which themselves are influenced by climate, is key to achieving science-based policy outcomes for effective land and forest management.

Science, this issue p. eaaz7005

Forests have considerable potential to help mitigate human-caused climate change and provide society with a broad range of cobenefits. Local, national, and international efforts have developed policies and economic incentives to protect and enhance forest carbon sinksranging from the Bonn Challenge to restore deforested areas to the development of forest carbon offset projects around the world. However, these policies do not always account for important ecological and climate-related risks and limits to forest stability (i.e., permanence). Widespread climate-induced forest die-off has been observed in forests globally and creates a dangerous carbon cycle feedback, both by releasing large amounts of carbon stored in forest ecosystems to the atmosphere and by reducing the size of the future forest carbon sink. Climate-driven risks may fundamentally compromise forest carbon stocks and sinks in the 21st century. Understanding and quantifying climate-driven risks to forest stability are crucial components needed to forecast the integrity of forest carbon sinks and the extent to which they can contribute toward the Paris Agreement goal to limit warming well below 2C. Thus, rigorous scientific assessment of the risks and limitations to widespread deployment of forests as natural climate solutions is urgently needed.

Many forest-based natural climate solutions do not yet rely on the best available scientific information and ecological tools to assess the risks to forest stability from climate-driven forest dieback caused by fire, drought, biotic agents, and other disturbances. Crucially, many of these permanence risks are projected to increase in the 21st century because of climate change, and thus estimates based on historical data will underestimate the true risks that forests face. Forest climate policy needs to fully account for the permanence risks because they could fundamentally undermine the effectiveness of forest-based climate solutions.

Here, we synthesize current scientific understanding of the climate-driven risks to forests and highlight key issues for maximizing the effectiveness of forests as natural climate solutions. We lay out a roadmap for quantifying current and forecasting future risks to forest stability using recent advances in vegetation physiology, disturbance ecology, mechanistic vegetation modeling, large-scale ecological observation networks, and remote sensing. Finally, we review current efforts to use forests as natural climate solutions and discuss how these programs and policies presently consider and could more fully embrace physiological, climatic, and permanence uncertainty about the future of forest carbon stores and the terrestrial carbon sink.

The scientific community agrees that forests can contribute to global efforts to mitigate human-caused climate change. The community also recognizes that using forests as natural climate solutions must not distract from rapid reductions in emissions from fossil fuel combustion. Furthermore, responsibly using forests as natural climate solutions requires rigorous quantification of risks to forest stability, forests carbon storage potential, cobenefits for species conservation and ecosystem services, and full climate feedbacks from albedo and other effects. Combining long-term satellite records with forest plot data can provide rigorous, spatially explicit estimates of climate changedriven stresses and disturbances that decrease productivity and increase mortality. Current vegetation models also hold substantial promise to quantify forest risks and inform forest management and policies, which currently rely predominantly on historical data.

A more-holistic understanding and quantification of risks to forest stability will help policy-makers effectively use forests as natural climate solutions. Scientific advances have increased our ability to characterize risks associated with a number of biotic and abiotic factors, including risks associated with fire, drought, and biotic agent outbreaks. While the models that are used to predict disturbance risks of these types represent the cutting edge in ecology and Earth system science to date, relatively little infrastructure and few tools have been developed to interface between scientists and foresters, land managers, and policy-makers to ensure that science-based risks and opportunities are fully accounted for in policy and management contexts. To enable effective policy and management decisions, these tools must be openly accessible, transparent, modular, applicable across scales, and usable by a wide range of stakeholders. Strengthening this science-policy link is a critical next step in moving forward with leveraging forests in climate change mitigation efforts.

Leveraging cutting-edge scientific tools holds great promise for improving and guiding the use of forests as natural climate solutions, both in estimating the potential of carbon storage and in estimating the risks to forest carbon storage.

Forests have considerable potential to help mitigate human-caused climate change and provide society with many cobenefits. However, climate-driven risks may fundamentally compromise forest carbon sinks in the 21st century. Here, we synthesize the current understanding of climate-driven risks to forest stability from fire, drought, biotic agents, and other disturbances. We review how efforts to use forests as natural climate solutions presently consider and could more fully embrace current scientific knowledge to account for these climate-driven risks. Recent advances in vegetation physiology, disturbance ecology, mechanistic vegetation modeling, large-scale ecological observation networks, and remote sensing are improving current estimates and forecasts of the risks to forest stability. A more holistic understanding and quantification of such risks will help policy-makers and other stakeholders effectively use forests as natural climate solutions.

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Climate-driven risks to the climate mitigation potential of forests - Science Magazine