Tuesday, January 26, 2021

GoLocalProv News Team

The university says the donation is intended to allow Brown to attract and retain world-class teachers and scholars, and it will endow an innovation awards program at the Universitys Robert J. and Nancy D. Carney Institute for Brain Science to provide seed funding for new high-impact research in computation and other areas of brain science.

This transformational gift recognizes the momentum that continues to build at Brown University, where our talented faculty are leading scientific discovery including in the rapidly emerging specialty of computational brain science, said Diane Lipscombe, director of the Carney Institute and a professor of neuroscience. This gift will allow us to sustain a culture of innovation, which has led to an impressive number of discoveries and returned countless new grants to Brown that forge new areas of research.

With more than 180 affiliated faculty members in 20 units and eight affiliated graduate programs, theCarney Instituteis pursuing research that has real-life, human applications, Lipscombe said. Core areas of research include work on innovative advances in computational brain science to investigate cognition, behavior and mood disorders; novel technologies to interface with the brain to understand brain circuits and restore lost functions; and research into the mechanisms of cell death to identify therapies for neurodegeneration, such as in amyotrophic lateral sclerosis (ALS) and Parkinsons and Alzheimers diseases.

This new $25 million gift is part of the Universitys $3-billionBrownTogethercampaign, which has raised $2.74 billion to date. It also builds upon significant philanthropic investment in Browns cutting-edge work in brain science of the total contributed by donors to date, more than $187 million has been raised to support research and education in brain science, including a$100 million giftthat named the institutein 2018. The gifts support a core research priority in BrownsBuilding on Distinctionstrategic plan: understanding the human brain.

In 2014, the Carney Institute launched aninnovation awards program to support early-stage research projects that are too new to attract external funding but have great potential to advance science and benefit society. The new gift will endow a similar innovation awards program, ensuring that the Carney Institute will be able to sustainably invest in innovation for years to come.

Ashley Webb, an assistant professor of molecular biology, cell biology and biochemistry at Brown, received an innovation award in 2019 to establish a new system to study how neurons age. She is developing a cell reprogramming platform, called direct reprogramming, to study aging in the hypothalamus brain region. The hypothalamus controls critical processes, such as sleep, temperature regulation, eating and metabolism, which can become dysregulated with aging. With direct reprogramming, Webb is able to convert a skin cell, for example, into a brain cell that maintains the hallmarks of aging.

Aging is the greatest risk factor for a number of diseases, including neurodegenerative diseases such as Alzheimers, Webb said. If we understand whats going wrong during aging, this will give us important insight into the mechanisms of disease. But right now, we dont have very good systems for studying these diseases in the context of aging. This is the problem we are working to solve.

Promoting computational brain science at Brown

According to Brown, the anonymous gift will allow Caarney to continue to lead in the emerging field of computational neuroscience. Last summer, Brownestablishedthe Center for Computational Brain Science at the institute to harness the Universitys expertise in computation, cognition and systems neuroscience. A portion of the new gift will support research in the center.

Computational neuroscience is a multidisciplinary field that seeks to understand the functions of the brain at all levels from cells to cognition using principles from physics, mathematics, engineering, computer science, biology, cognitive science and psychology. The center creates collaborations between basic brain science researchers and engineers, mathematicians and computer scientists, and brings computational neuroscience innovations to clinical applications and commercialization.

According to Michael Frank director of the Center for Computational Brain Science andthe recent recipientof the National Academy of Sciences Troland Award for early-career researchers the gift is a statement of support, confidence and appreciation for the contributions of computational neuroscientists at Brown. The $25 million gift will fuel the growing momentum to establish the newly minted computational brain science center as a world leader, he said.

It will expand the scope with which brain scientists can leverage powerful computational methods to understand neural mechanisms of complex behavior; to learn from, and reciprocally inspire, development in artificial intelligence; and to facilitate translation to improve brain health, Frank said.

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$25 Million Anonymous Gift Made to Brown for Brain Science Initiatives - GoLocalProv