Johns Hopkins Kimmel Cancer Center and Johns Hopkins University researchers recently conducted some laboratory studies about cancer. They explored how cancer cells may develop from an initial tumor to a remote site within the body, a process known as metastasis.

The scientists usedtissue engineeringto determine how groups of cells migrate to other parts of the body. They also usedtissue engineeringto build up a useful 3-D blood vessel and grewbreast cancer cellsnearby. They recognized the cancer cell falling out to the blood vessel and getting over a stretch of the cell wall. A group of tumor cells is easily released into the bloodstream to migrate to distant places. These are all happening because of the attachment to the blood vessels. Blood vessels also could constrict by the cancer cell, pull on them, or cause them to leak.

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The study was published in the journalCancer Researchpublished on July 14. Senior study author Andrew Ewald, Ph.D., co-director of the Cancer Invasion and Metastasis Program at the Johns Hopkins Kimmel Cancer Center and professor of cell biology at the Johns Hopkins University School of Medicine, said this: We observed that cancer can also rapidly reshape, destroy or integrate into existing blood vessels.

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They also organized the practice in close teamwork with the lab of Peter Searson, Ph.D., Joseph R., and Lynn C. Reynolds, Professor of Materials Science and Engineering, with collective choices in the areas of biomedical engineering, oncology, and physical medicine and rehabilitation.

Ewald says. Just as people going scuba diving versus ice climbing require different tools, cancer brings different equipment depending on the job they also intend to perform. Determining what that equipment is can help us understand how to stop cancer.

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Ewald and associates proposed to see groups of eight to 10 cells, allowing a tumor, moving through a protein wall and crushing between blood vessel walls to travel. We never saw that, What we kept seeing instead was that a piece of an existing tumor would take over a neighboring blood vessel wall, putting cells in direct contact with the circulation, and that the cancer cells could do so in a matter of hours. They didnt have to invade past the blood vessels; they became the blood vessels, and could just release cancer cells there.

The 3-D model changed to study added features of the tumor microenvironment or to examine alternate cancer types, Ewald says.

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Cancer cells reshape spread into the blood, a new study says - News Landed