Matthus Mittasch, Vanna M. Tran, Manolo U. Rios, Anatol W. Fritsch, Stephen J. Enos, Beatriz Ferreira Gomes, Alec Bond, Moritz Kreysing, Jeffrey B. Woodruff

Centrosomes withstand microtubule-mediated forces during spindle assembly, yet they are disassembled by similar forces during mitotic exit. Mittasch et al. use nanorheology to probe the material properties of centrosomes and how they change during the cell cycle. In anaphase, the centrosome scaffold becomes weak and brittle, thus allowing force-induced disassembly.

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Journal of Cell Biology | Rockefeller University Press