The Salk Institute has hired two new faculty members, bringing expertise in immunology and mitochondrial function.

* Susan Kaech will become director of the Norris Center for Immunobiology and Microbial Pathogenesis.

* Gerald Shadel will join Salks Molecular and Cell Biology Laboratory.

Kaech studies how immune cells called T cells remember previous infections, so they can respond more quickly to the same infection. Shes also studied how cancer suppresses the immune response.

Shadel specializes in the roles of mitochondrial dysfunction in aging and disease. Mitochondria are cellular organelles that contain their own DNA and are best known as the cells energy producers. Unhealthy mitochondria are a factor in Alzheimers and Parkinsons diseases, as well as cardiovascular ailments.

Both currently at Yale University, they are scheduled to arrive in early 2018. While married to each other, Kaech and Shadel conduct their research independently.

Kaechs research has won her awards including the Howard Hughes Medical Institute Early Career Scientist award, the Presidential Early Career Award for Scientists and Engineers, the Edward Mallinckrodt Jr. award and the Burroughs-Wellcome Foundation award.

Kaech and Shadel said they were attracted to the Salk Institute not only because of its reputation as a center of basic research, but by the scientific community in San Diego as a whole.

The scientific community is very welcoming and warm and scientifically interactive, Kaech said.

Moreover, the scientific community participates in the larger San Diego community, taking part in activities such as educational outreach, fundraising and philanthropy.

It seems to be a little bit more vibrant in the San Diego community than what I've experienced before, Kaech said.

Likewise, the nonscientific community is interested in what San Diego scientists are doing.

So that's another kind of attraction, (the interest) seems a little bit more communitywide, Kaech said. Science is clearly on the minds of people in San Diego.

The Salk Institute itself exemplifies this collaborative spirit, Kaech said.

Great minds are there, all interacting together, she said. How they cross-fertilize each other's research is very exciting, for me to be a part of that.

Shadels honors include an Amgen Outstanding Investigator award, the Glenn Foundations Glenn Award for Research in Biological Mechanisms of Aging and the Glenn/AFAR Breakthroughs in Gerontology Award.

Shadel said being located at the Salk Institute will put him in a better position to study the multiple functions of mitochondria, in part by interdisciplinary research with other experts.

I think my lab has been instrumental, along with others, to show that mitochondria are integrated into cells for other reasons in addition to the energetic functions, Shadel said.

What really excited me about the Salk was this chance to interact with really great experts in other fields and bring my research to the interface with other disciplines and really answer questions in bold new ways.

I also knew several of the people who were professors there already who are involved in the aging research realm mostly, but also others are involved in metabolism as well.

What this leads to is the power of fundamental science to help solve some of societys most pressing problems, Shadel said.

In my opinion, the most transformative types of discoveries are born out of pure basic research endeavors, and the Salk Institute has a really rich history of groundbreaking basic science, he said.

bradley.fikes@sduniontribune.com

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UPDATES:

The Salk Institute has hired two new faculty members, bringing expertise in immunology and mitochondrial function. Both from Yale University, they are scheduled to arrive in early 2018 with the rank of full professor.

-- Susan Kaech will become director of the Norris Center for Immunobiology and Microbial Pathogenesis. She studies how immune cells called T cells remember previous infections, enabling them to mobilize more rapidly to subsequent exposure.

-- Gerald Shadel will join the Salks Molecular and Cell Biology Laboratory. He is noted for research on the role of mitochondrial dysfunction in aging and disease. Mitochondria are organelles that contain their own DNA.

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Salk Institute hires two noted researchers - The San Diego Union-Tribune