Every time a cell in the early embryo divides, three mutations creep in; a rate much higher than previously thought.
Asian Scientist Newsroom | March 29, 2017 | In the Lab
AsianScientist (Mar. 29, 2017) - From the time a zygote first divides into two cells, very early mutations determine which cell becomes more dominant and leads to a higher proportion of the adult body. These findings have been published in Nature.
The earliest stages of human development have been impossible to study directly until now. In the present study, researchers analyzed the whole genome sequences of blood samples collected from 279 individuals with breast cancer and discovered 163 mutations that occurred very early in the embryonic development of those people.
Once identified, the researchers used mutations from the first, second and third divisions of the fertilized egg to calculate which proportion of adult cells resulted from each of the first two cells in the embryo.
They found that these first two cells contribute differently to the whole body. One cell gives rise to about 70 percent of the adult body tissues, whereas the other cell has a more minor contribution, leading to about 30 percent of the tissues. This skewed contribution continues for some cells in the second and third generation too.
Originally pinpointed in normal blood cells from cancer patients, the researchers then looked for these mutations in cancer samples that had been surgically removed from the patients during treatment. Unlike normal tissues composed of multiple somatic cell clones, a cancer develops from one mutant cell. Therefore, each proposed embryonic mutation should either be present in all of the cancer cells in a tumor, or none of them. This proved to be the case, and by using these cancer samples, the researchers were able to validate that the mutations had originated during early development.
This is the first time that anyone has seen where mutations arise in the very early human development. It is like finding a needle in a haystack. There are just a handful of these mutations, compared with millions of inherited genetic variations, and finding them allowed us to track what happened during embryogenesis, said Dr. Young Seok Ju, first author from the Wellcome Trust Sanger Institute and the Korea Advanced Institute of Science and Technology (KAIST).
During this study, the researchers were also able to measure the rate of mutation in early human development for the first time, up to three generations of cell division. Previous researchers had estimated one mutation per cell division, but this study measured three mutations for each cell doubling, in every daughter cell.
Mutations during the development of the embryo occur by two processes known as mutational signatures 1 and 5. These mutations are fairly randomly distributed through the genome, and the vast majority of them will not affect the developing embryo. However, a mutation that occurs in an important gene can lead to disease such as developmental disorders.
This is a significant step forward in widening the range of biological insights that can be extracted using genome sequences and mutations, said Sir Mike Stratton, lead author on the paper and Director of the Sanger Institute.
Essentially, the mutations are archaeological traces of embryonic development left in our adult tissues, so if we can find and interpret them, we can understand human embryology better. This is just one early insight into human development, with hopefully many more to come in the future.
The article can be found at: Ju et al. (2017) Somatic Mutations Reveal Asymmetric Cellular Dynamics in the Early Human Embryo.
Source: KAIST; Photo: Shutterstock. Disclaimer: This article does not necessarily reflect the views of AsianScientist or its staff.
Read more from the original source:
A Glimpse Into The Earliest Genetic Mutations Of Human Life - Asian Scientist Magazine
- World Embryology Day: Know the world of baby scientists, and how this can impact the success rate of your IV.. - ETHealthWorld - August 5th, 2024 [August 5th, 2024]
- ESHRE Ferti Job Hub: A New Initiative for Employers and Job Seekers in Human Reproduction and Embryology - ESHRE - June 1st, 2024 [June 1st, 2024]
- Understanding Synthetic Embryology and Its Implications for Healthcare - Medriva - February 13th, 2024 [February 13th, 2024]
- These are the six things to think about before freezing your eggs - Daily Mail - May 5th, 2023 [May 5th, 2023]
- Merck Foundation CEO and Liberia First Lady Report the Impact of Their Long-Term Partnership to Transform Patient Care in Liberia - Devdiscourse - May 5th, 2023 [May 5th, 2023]
- USask researcher aims to revolutionize human-assisted reproduction - USask News - May 5th, 2023 [May 5th, 2023]
- IVF works for the lucky few. After a decade, I finally realised I wasnt one of them - The Guardian - May 5th, 2023 [May 5th, 2023]
- When your mother's not your mother and the problems of ... - The Tablet - May 5th, 2023 [May 5th, 2023]
- On World Veterinary Day Let us Celebrate the Diversity of the Noble ... - Rising Kashmir - May 5th, 2023 [May 5th, 2023]
- Can exercise help with Endometriosis? - EchoLive.ie - March 31st, 2023 [March 31st, 2023]
- Fertility expert shares the seven things you need to know before freezing your eggs - The Mirror - March 31st, 2023 [March 31st, 2023]
- Arlington and Alexandria Bring Home the 4-H Ribbons - Virginia Connection Newspapers - March 31st, 2023 [March 31st, 2023]
- PINNACLE FERTILITY ANNOUNCES THE PROMOTION OF BETH ... - PR Newswire - March 31st, 2023 [March 31st, 2023]
- Delay in early development of the embryo associated with likelihood of miscarriage - News-Medical.Net - March 31st, 2023 [March 31st, 2023]
- Rumi Scientific Appoints Allen A. Fienberg, Ph.D., as Chief Executive Officer and Chairman of the Board of - EIN News - March 31st, 2023 [March 31st, 2023]
- Human Fertilisation and Embryology Authority consults on proposed ... - Solicitors Journal - March 6th, 2023 [March 6th, 2023]
- Abortion may be legal in Argentina but women still face major obstacles - BBC - March 6th, 2023 [March 6th, 2023]
- Scientists urge pregnant women to avoid using plastic bottles - Daily Mail - March 6th, 2023 [March 6th, 2023]
- Precongress courses at ESHRE23 characterised by practicality and ... - ESHRE - March 6th, 2023 [March 6th, 2023]
- Couple's Child Has Deadly Cancer Gene Thanks to IVF Clinic's ... - The Daily Beast - March 6th, 2023 [March 6th, 2023]
- Three-parent baby technique could create babies at risk of severe disease - MIT Technology Review - March 6th, 2023 [March 6th, 2023]
- UK ministers urged to consider changing law to allow genome editing of human embryos: Report - WION - March 6th, 2023 [March 6th, 2023]
- Surrogacy: the strict approach to consent - Lexology - March 6th, 2023 [March 6th, 2023]
- In politics, there's no such thing as private faith - The Times - March 6th, 2023 [March 6th, 2023]
- Delayed motherhood: Why more women are opting to freeze their ... - Eve Magazine - March 6th, 2023 [March 6th, 2023]
- National Science Day & Rare Disease Day Observed At ILS ... - Ommcom News - March 6th, 2023 [March 6th, 2023]
- Comparative Embryology - Developmental Biology - NCBI Bookshelf - October 20th, 2022 [October 20th, 2022]
- A guided route - The Hindu - October 20th, 2022 [October 20th, 2022]
- How infertility drove me into reproductive medicine | The Guardian Nigeria News - Nigeria and World News Guardian Woman - Guardian Nigeria - October 20th, 2022 [October 20th, 2022]
- Quran and the Modern Science - Brighter Kashmir - October 3rd, 2022 [October 3rd, 2022]
- Jehangir Hospital launches state of the art IVF centre with best facilities - Devdiscourse - October 3rd, 2022 [October 3rd, 2022]
- Dead fish breathes new life into the evolutionary origin of fins and limbs - EurekAlert - October 3rd, 2022 [October 3rd, 2022]
- Merck Foundation Together with African First Ladies Mark 'World Heart Day 2022' - The Week - October 3rd, 2022 [October 3rd, 2022]
- The LA Times gets abortion and the Church dramatically wrong - Angelus News - October 3rd, 2022 [October 3rd, 2022]
- THE CASE FOR INVAGINATION #4 Comes to The Mass Building - Broadway World - September 9th, 2022 [September 9th, 2022]
- Improving medical student recruitment into neurosurgery through teaching reform - BMC Medical Education - BMC Medical Education - September 9th, 2022 [September 9th, 2022]
- Embryology: Definition & Development Stages - Study.com - August 24th, 2022 [August 24th, 2022]
- Embryology, Ear - StatPearls - NCBI Bookshelf - August 24th, 2022 [August 24th, 2022]
- Fertility law and regulation need to changehere's how it could happen - The BMJ - August 24th, 2022 [August 24th, 2022]
- Indiana Family Health Council pushes for more sex ed after abortion ban - WTHR - August 24th, 2022 [August 24th, 2022]
- Letter writer disturbed by abortion support | Letters to the Editor | thebrunswicknews.com - Brunswick News - August 24th, 2022 [August 24th, 2022]
- How spilled coffee inspired a Boston sperm-testing startup - The Boston Globe - August 24th, 2022 [August 24th, 2022]
- Merck Foundation CEO Acknowledged Zimbabwe First Lady's Efforts as Ambassador of More than a Mother to Build Healthcare Capacity, Break Infertility S... - August 24th, 2022 [August 24th, 2022]
- Pig Development - Embryology - UNSW Sites - August 16th, 2022 [August 16th, 2022]
- Master of Clinical Embryology - Study at Monash University - August 16th, 2022 [August 16th, 2022]
- Letter: The inconvenient science of embryology - INFORUM - August 16th, 2022 [August 16th, 2022]
- Letters to the Editor August 13, 2022 | The Citizen - Ortonville Citizen - August 16th, 2022 [August 16th, 2022]
- Scientists Are Learning How to Help Coral Reefs Save Themselves - AAAS - August 16th, 2022 [August 16th, 2022]
- Hypospadias: A Comprehensive Review Including Its Embryology, Etiology and Surgical Techniques - Cureus - August 8th, 2022 [August 8th, 2022]
- Woman, 20, jailed in UK for taking abortion pills when abusive partner got her pregnant - The Mirror - August 8th, 2022 [August 8th, 2022]
- Woman gives birth to triplets with two-year age gaps between them - The Independent - August 8th, 2022 [August 8th, 2022]
- The earliest segmental sternum in a Permian synapsid and its implications for the evolution of mammalian locomotion and ventilation | Scientific... - August 8th, 2022 [August 8th, 2022]
- Egg donors in the UK: What it's actually like donating your eggs - Cosmopolitan UK - July 31st, 2022 [July 31st, 2022]
- Elon Musks Babies Were Conceived Via IVF And Surrogacy - Is It The Future Of Reproduction? - Forbes - July 31st, 2022 [July 31st, 2022]
- Handful of Tories declare themselves as candidates to replace Johnson - Morning Star Online - July 15th, 2022 [July 15th, 2022]
- Y Combinator-Backed Lilia Launches A More Convenient And Affordable Egg Freezing Offering Built For The Millennial Women - Forbes - July 15th, 2022 [July 15th, 2022]
- The End of the Beginning of the End of Abortion | Hadley Arkes - First Things - June 25th, 2022 [June 25th, 2022]
- Widower wins right to have baby using embryo created with his late wife - The Guardian - June 25th, 2022 [June 25th, 2022]
- How Does Comparative Embryology Support the Theory of Evolution? - June 25th, 2022 [June 25th, 2022]
- IVF: Three key requirements before you can have fertility treatment on the NHS - Express - June 25th, 2022 [June 25th, 2022]
- Harry Potter's World Similar to the Magic of Endocrinology - Medscape - June 25th, 2022 [June 25th, 2022]
- L'Oral-UNESCO For Women in Science International Awards 2022 - Benzinga - Benzinga - June 7th, 2022 [June 7th, 2022]
- Women, Witches, and Abortion: A Misguided Attack on Justice Alito - Public Discourse - June 7th, 2022 [June 7th, 2022]
- Updates to the Human Fertilisation and Embryology (HFE) Act - Lexology - May 6th, 2022 [May 6th, 2022]
- Widower in High Court fight over use of embryo created after IVF treatment - Forres Gazette - May 6th, 2022 [May 6th, 2022]
- Australia Moves Ahead Cautiously With '3-Parent IVF' - WIRED - May 6th, 2022 [May 6th, 2022]
- I donated sperm to father 47 kids but women don't want to date me - New York Post - May 6th, 2022 [May 6th, 2022]
- The Virtual Human Embryo - EHD - April 23rd, 2022 [April 23rd, 2022]
- Embryology Definition & Meaning - Merriam-Webster - April 23rd, 2022 [April 23rd, 2022]
- Buyer Beware: IVF Damages and the Value of Life - American Council on Science and Health - April 23rd, 2022 [April 23rd, 2022]
- The Stark Reality of Parents' COVID Deaths Grandparents Step In - The Washington Informer - April 23rd, 2022 [April 23rd, 2022]
- IVF Add-Ons: Why You Should Be Cautious Of These Expensive Procedures - SheThePeople - April 23rd, 2022 [April 23rd, 2022]
- Attitude And Perception Of Medical Students Towards Histolog | AMEP - Dove Medical Press - April 23rd, 2022 [April 23rd, 2022]
- Science in the Neighborhood Public Lecture Dr. Alexandria Forbes - Carnegie Institution for Science - April 9th, 2022 [April 9th, 2022]
- Scots mum's heartbreak as UK law stops teen daughter moving to America to join her family - Daily Record - April 9th, 2022 [April 9th, 2022]
- In Vitro Fertilization Market Analysis by Production, Consumption and Competitive Analysis Till 2028 Mianeh - Mianeh - April 9th, 2022 [April 9th, 2022]
- Embryology - Embryogenesis, Human Development and Stages ... - December 28th, 2021 [December 28th, 2021]
- Frozen Embryos: Who Gets Them? Who Keeps Them? Who Destroys Them? And When? - American Council on Science and Health - December 28th, 2021 [December 28th, 2021]
- New muscle layer discovered on the human jaw - The Indian Express - December 28th, 2021 [December 28th, 2021]
- Demystifying IVF: Everything You Need To Know (Including Chances Of Success) - Momtastic - December 16th, 2021 [December 16th, 2021]