A Taiwan vole, closely related to the creeping vole described in the study. Credit: Lai Wagtail / Flickr (CC BY-NC-ND 2.0)

Open up Scott Roys Twitter bio and youll see a simple but revealing sentence: The more I learn the more Im confused. Now the rest of the scientific world can share in his confusion. The San Francisco State University associate professor of Biologys most recent research, published earlier this month in one of the scientific worlds most prestigious journals, catalogues a strange and confounding system of genes in a tiny rodent that scientists have ignored for decades.

This is basically the weirdest sex chromosome system known to science, Roy said. Nobody ordered this. But hes serving it anyway.

The owner of those chromosomes is the creeping vole, a burrowing rodent native to the Pacific Northwest. Scientists have known since the 60s that the species had some odd genes: Their number of X and Y chromosomes (bundles of DNA that play a large role in determining sex) is off from whats expected in male and female mammals.

That finding caught Roys eye when presented by a guest speaker at a San Francisco State seminar, and he realized that modern technology might be able to shed new light on the mysteries hiding in the voles DNA. After working with collaborators to disentangle the voles genetic history resulting in one of the most completely sequenced mammal genomes that exists, according to Roy the story only got stranger.

The team found that the X and Y chromosomes had fused somewhere in the rodents past, and that the X chromosome in males started looking and acting like a Y chromosome. The numbers of X chromosomes in male and female voles changed too, along with smaller pieces of DNA getting swapped between them. The researchers published their results in Science on May 7, 2021.

Drastic genetic changes like these are exceptionally rare: The way genes determine sex in mammals has stayed mostly the same for about 180 million years, Roy explains. Mammals, with few exceptions, are kind of boring, he said. Previously we would have thought something like this is impossible.

So how did the genes of this unassuming rodent end up so jumbled? Its not an easy question to answer, especially since evolution is bound to produce some strangeness simply by chance. Roy, however, is determined to figure out the why. He suspects that what the team found in the voles genome is something like the aftermath of an evolutionary battle for dominance between the X and Y chromosome.

The research couldnt have happened, Roy says, without collaborations with Oregon fish and wildlife biologists who had a creeping vole sample sitting in a lab freezer. He also teamed up with a group from Oklahoma State University when the two groups started chatting about creeping vole DNA sequences that were posted on the internet and both realized they were working on the same question.

Another key was working at a teaching-focused institution. Roy says he has the time to develop ideas with colleagues and students at SF State, and he can do research where he doesnt quite know what hell find. This is a great example of non-hypothesis-based biology, Roy explained. The hypothesis was, This system is interesting. I bet if you looked into it some more, thered be other interesting things.

It wont be the last time Roys lab goes out on a limb. He and his collaborators plan to look into the genomes of other species related to the voles to chart the evolutionary path that led to this strange system. Hell also continue DNA sequencing curiosities across the tree of life.

These bizarre systems give us a handhold to start to understand why the more common systems are the way they are and why our biology works as it does, he explained. By delving into the weirdest that nature has to offer, maybe we can come to understand ourselves better, too.

Reference: Sex chromosome transformation and the origin of a male-specific X chromosome in the creeping vole by Matthew B. Couger, Scott W. Roy, Noelle Anderson, Landen Gozashti, Stacy Pirro, Lindsay S. Millward, Michelle Kim, Duncan Kilburn, Kelvin J. Liu, Todd M. Wilson, Clinton W. Epps, Laurie Dizney, Luis A. Ruedas and Polly Campbell, 7 May 2021, Science.DOI: 10.1126/science.abg7019

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Research on Bizarre Rodent Genetics Solves a Mystery And Then Things Got Even Stranger - SciTechDaily