This webinar will present recent studies from Dr. Petter Brodin's group at Karolinska Institute in Stockholm that provide important new insights into the immune system responses to SARS-CoV-2 infection. These studies took a systems-level approach to analyze both the cellular and protein components involved, using methodologies including mass cytometry, flow cytometry and high-multiplex proteomics.

A longitudinal study of severe COVID-19 patients identified distinct patterns of immune cell coregulation in four different stages of the disease and demonstrated a shared trajectory of immunological recovery that may provide future biomarkers of disease progression. In an investigation of Multisystem Inflammatory Syndrome in Children (MIS-C), a relatively rare complication of SARS-CoV-2 infection in children, important differences in inflammatory response were seen between MIS-C and severe COVID-19 in adults. Moreover, while some similarities were observed between inflammatory responses in MIS-C and Kawasaki disease, important differences were also apparent, particularly in the T-cell subsets involved.

Key Learning Objectives

Who Should Attend

Certificate of attendance

All webinar participants can download a certificate of attendance for continuing education purposes from the webinar auditoriums resources section.

Read the original:
A systems-level approach to understanding the immunology of COVID-19 in adults and children on SelectScience - SelectScience